OU Surgery News - Newsletter Spring/Summer/Fall/Winter 2020

SURGERY NEWS Spring/Summer/Fall/Winter 2020

Issue No. 5

Table of Contents Letter from the Chair Department of Surgery 2020 Overview Division of Cardiac, Thoracic & Vascular Surgery Division of General Surgery/Trauma Surgery/Critical Care Division of Pediatric Surgery Division of Plastic & Reconstructive Surgery Division of Surgical Oncology Division of Transplant Surgery Research Education In the Community

MESSAGE FROM THE CHAIR

Welcome to the Department of Surgery at the University of Oklahoma. This year we accomplished pandemic needs and surgical needs. We balanced working from home and taking care of patients. Simply, we found a way to persevere. I hope you enjoy learning about the continued success and accomplishments of members of this department.

First, I would like to highlight that we have a new Division of Transplant Surgery. Our new Division Chief, Tomasz Kozlowski, M.D., has put together a tremendous team that includes transplant surgeon, Narendra Battula M.D. and transplant nephrologist Elzbieta Kozlowska, M.D. I am very excited about where this division will take transplantation for our department and the state of Oklahoma.

I would also like to congratulate Suhair Maqusi, M.D. on her new role as Division Chief of Plastic and Reconstructive Surgery. Her leadership has brought new surgeons, a new educational curriculum, and a vision to take us into the future.

Finally, I would like to compliment our graduating residents and fellows. Despite the pressure of the pandemic they performed at the highest level. I believe every year we graduate the top surgeons in the country. I know we will be proud to watch where their careers take them.

Barish H. Edil Professor & Chair

DEPARTMENT MISSION STATEMENT To improve the health of all people, to deliver excellent, innovative patient care, and to educate physicians and surgeons for the future

Clinical Faculty: 58

Total Staff including Advance Practice Providers: 50

Number of Residents: 33

Number of Fellows: 7

Total Number of Clinic Visits: 20,112 Total wRVUs: 225,228.43 Total Number of OR Cases: 37,994

SURGERY DIVISIONS by the Numbers January 1, 2020 - December 31, 2020

OR Cases Cardiac Surgery 6,093

General Surgery 1,807

Surgical Oncology Breast 1,051 Transplant Surgery 276

Pediatric Surgery 3,034

Surgical OncologyGI/Colorectal 4,013 Trauma/Critical Care Surgery 21,777

Plastic Surgery 1,537 Thoracic Surgery 993

Vascular Surgery 989

(Oct-Dec 2020)

wRVUs Cardiac Surgery 55,142.30 Surgical Oncology Breast 13,317.56 Transplant Surgery 990.31

General Surgery 16,168.28

Pediatric Surgery 25,330.73

Surgical OncologyGI/Colorectal 24,625.47 Trauma/Critical Care Surgery 69,693.71

Plastic Surgery 21,792.08 Thoracic Surgery 9,967.45 Vascular Surgery 8,037.16

(Oct-Dec 2020)

Clinical Visits Cardiac Surgery 239 Surgical Oncology Breast 3,401 Transplant Surgery 0 (Oct-Dec 2020)

General Surgery 3,099

Pediatric Surgery 2,225

Surgical OncologyGI/Colorectal 3,812 Trauma/Critical Care Surgery 3,063

Plastic Surgery 3,656 Thoracic Surgery 1,178 Vascular Surgery 490

Division of Cardiac, Thoracic & Vascular Surgery

Harold Burkhart, MD Professor and Division Chief Pediatric Cardiothoracic Surgical Program Director CHF Brandon Weeden Chair in Pediatric Cardiac Surgery

Clinical Faculty Pediatric Cardiac Surgery Harold Burkhart, MD Yuki Nakamura, MD

Adult Cardiac Surgery Lacey Harville, MD Luis Daniel Velazco Davila, MD

Thoracic Surgery Argenis Herrera, MD J. Matthew Reinermans, MD

Vascular Surgery Joshua Gierman, MD

The Division of Cardiac, Thoracic & Vascular Surgery welcomes Dr. Argenis Herrera and Dr. Yuki Nakamura. Adult Cardiac Surgery will be a part of a Multi-center trial looking at Acute Renal Failure Prevention in Cardiac Surgery. Also involved in a surgical trial in conjunction with OU Cardiology Electrophysiologist Dr. Stavros looking into etiology and prevention of Atrial Fibrillation in Cardiac Surgery Patients.

Dr. Argenis Herrera joins us as an Assistant Professor from Moffitt Cancer Center in Tampa, Florida. His areas of interest include benign and malignant esophageal pathology, thoracic oncology, chest wall reconstruction, minimally invasive surgical approaches including endoscopic, bronchoscopic, VATS, laparoscopic and robotic procedures.

Dr. Yuki Nakamura joins us as an Assistant Professor from the University of Iowa. His areas of research interest include patient-specific implants in pediatric cardiac surgery and surgical simulation using 3D modeling/printing technologies.

New Hires

Awards & Recognition Harold Burkhart, MD CHF Brandon Weeden Chair in Pediatric Surgery Chair Ad Hoc Tenure Review Committee Member Faculty Board 2020 Top Doc Southern Thoracic Surgical Association, Program Committee Co-Chair Top Performance Award of the Editorial Board - Journal of Thoracic and Cardiovascular Surgery Self-Education/Self Assessment in Thoracic Surgery (SESATS) XIII, 13th Edition: Sub Section Editor Joshua Gierman, MD Member Student Promotions Committee

Argenis Herrera, MD

Lacey Harville, MD 2019-2020 Outstanding Teacher Award J. Matthew Reinersman, MD Member Student Appeals Board Luis Daniel Velazco Davila, MD Co-Director of the TAVR Program at OU (Percutaneous Aortic Valve Placement) Member of STS (Society of Thoracic Surgeons) and Southern Thoracic Society

Grants

Yuki Nakamura, MD

Patents

Harold Burkhart, MD Principle Investigator Presbyterian Health Foundation – 06/2021 A Matter of the Heart -- $1 million research fund for Hypoplastic Left Heart Syndrome $200,000

06/2020

Harold Burkhart, MD 1. Patent Title: Balloon Catheter Suturing Systems, Methods, and Devices Having Pledgets (European Patent) Patent No: 20191047.8 – 1122 Patent date: June 11, 2020 Country: Germany

Principle Investigator Presbyterian Health Foundation – 06/2021 Probabilistic in-Silico Modeling – Guided Management of Tricuspid Regurgitation in Hypoplastic Left Heart Syndrome Year 2 $93,926

2. Patent Title: Balloon Catheter Suturing Systems, Methods, and Devices Having Pledgets (European Patent) Patent No: 20190762.3 – 1122 Patent date: June 11, 2020 Country: Germany

Principle Investigator 01/2016 – Present A Prospective Study of Patients with Hypoplastic Left Heart Syndrome Following Stage II Surgical Palliation

07/2020

Presentations Harold Burkhart, MD Congenital Heart Disease - Surgical Palliation and treatment - Oral Presentation Mend a Heart 2 Lecture Series 1/16/20 & 2/6/20 Hypoplastic left heart syndrome - Current Surgical Management - Oral Presentation Mend a Heart 2 Lecture Series 1/10/20 & 1/30/20 J. Matthew Reinersman, MD Left thoracosopic truncal vagotomy for recalcitrant marginal ulcer - Oral Presentation Sternoclavicular joint infections: operative management and long-term functional outcomes - Oral Presentation Crafting a Cure - Oral Presentation Interview - Channel 9 News https://www.news9.com/story/5fc58f9f45d4820b ac7aa500/oklahoma-woman-goes-the-distanceagainst-cancer

Publications Harold Burkhart, MD Vincenti M, O'Leary PW, Qureshi MY, Seisler DK, Burkhart HM, Cetta F, Nelson TJ; Wanek HLHS Consortium Clinical Pipeline. Clinical Impact of Autologous Cell Therapy on Hypoplastic Left Heart Syndrome After Bidirectional Cavopulmonary Anastomosis. Semin Thorac Cardiovasc Surg. 2020 Nov 7:S1043-0679(20)30394-4. doi: 10.1053/j.semtcvs.2020.11.002. Epub ahead of print. PMID: 33171247.

Burkhart HM, Anderson HN. Commentary: Complete atrioventricular septal defect in young infants: The advantages of early repair. J Thorac Cardiovasc Surg. 2020 Sep 28:S00225223(20)32693-3. doi: 10.1016/j.jtcvs.2020.09.091. Epub ahead of print.

PMID: 33097212.

Mir A, Burkhart HM. Commentary: The role of valve-sparing aortic root surgery in congenital heart disease. J Thorac Cardiovasc Surg. 2020 Sep 19:S0022-5223(20)32661-1. doi: 10.1016/j.jtcvs.2020.09.063. Epub ahead of print.

PMID: 33036745.

Burkhart HM, Anderson HN. Commentary: Pulmonary vein stenosis: Not just a surgical solution. J Thorac Cardiovasc Surg. 2020 Jun 30:S0022-5223(20)31970-X. doi: 10.1016/j.jtcvs.2020.06.066. Epub ahead of print.

PMID: 32868046.

Burkhart HM, Phillips SD. Commentary: Pulmonary valve bioprosthesis: Longevity and reintervention. J Thorac Cardiovasc Surg. 2020 Aug 5:S0022-5223(20)32278-9. doi: 10.1016/j.jtcvs.2020.08.003. Epub ahead of print.

PMID: 32859415.

Ross CJ, Hsu MC, Baumwart R, Mir A, Burkhart HM, Holzapfel GA, Wu Y, Lee CH. Quantification of load-dependent changes in the collagen fiber architecture for the strut chordae tendineae-leaflet insertion of porcine atrioventricular heart valves.

Biomech Model Mechanobiol. 2020 Aug 18. doi: 10.1007/s10237-020-01379-4. Epub ahead of print. PMID: 32809131.

Hocker, J. R., Lerner, M. R., Lightfoot, S. A., Peyton, M. D., Thompson, J. L., Deb, S. J., Reinersman, M., Hanas, R. J., Postier, R. G., Edil, B. H., Burkhart, H. M., Hanas, J. S. (2020). Serum discrimination and phenotype assessment of coronary artery disease patents with and without type 2 diabetes prior to coronary artery bypass graft surgery. PloS one, 15(8), e0234539.

Burkhart, H. M., Mir, A. (2020). Commentary: Three-dimensional printing in congenital cardiac surgery: The future is now. (2nd ed., vol. 160, pp.

520-521). The Journal of thoracic and cardiovascular surgery.

Laurence, D. W., Johnson, E. L., Hsu, M. C., Baumwart, R., Mir, A., Burkhart, H. M., Holzapfel, G. A., Wu, Y., Lee, C. H. (2020). A pilot in silico modeling-based study of the pathological effects on the biomechanical function of tricuspid valves. International journal for numerical methods in biomedical engineering, 36(7), e3346.

Burkhart, H. M., Mir, A., Thompson, J. L. (2020).

Commentary: The Ross Procedure: An Operation in Need of More Support. Seminars in thoracic and cardiovascular surgery.

Publications Hudson, L. T., Jett, S. V., Kramer, K. E., Laurence, D. W., Ross, C. J., Towner, R. A., Baumwart, R., Lim, K. M., Mir, A., Burkhart, H. M., Wu, Y., Lee, C. H. (2020). A Pilot Study on Linking Tissue Mechanics with Load-Dependent Collagen Microstructures in Porcine Tricuspid Valve Leaflets. Bioengineering (Basel, Switzerland), 7(2).

Burkhart, H. M., Thompson, J. L., Mir, A. (2020).

Commentary: Is there still a role for the systemicto-pulmonary artery shunt in tetralogy? The Journal of thoracic and cardiovascular surgery.

Burkhart, H. M., Thompson, J. L., Anderson, H. N. (2020). Commentary: Congenital Aortic Valve Stenosis: Defining the Path to Success. Seminars in thoracic and cardiovascular surgery.

Ross, C. J., Laurence, D. W., Hsu, M. C., Baumwart, R., Zhao, Y. D., Mir, A., Burkhart, H. M., Holzapfel, G. A., Wu, Y., Lee, C. H. (2020). Mechanics of Porcine Heart Valves' Strut Chordae Tendineae Investigated as a Leaflet-Chordae-Papillary Muscle Entity. Annals of biomedical engineering.

Lacey Harville, MD Grimes, A. D., Velazco Davila, L. D., Cross, A. M., Harville, L. E. (2020). Delayed Finding of Atrial Rupture Following Significant Blunt Force Trauma. The American surgeon, 3134820933588.

J. Matthew Reinersman, MD Hocker, J. R., Lerner, M. R., Lightfoot, S. A., Peyton, M. D., Thompson, J. L., Deb, S. J., Reinersman, J. M., Hanas, R. J., Postier, R. G., Edil, B. H., Burkhart, H. M., Hanas, J. S. (2020). Serum discrimination and phenotype assessment of coronary artery disease patents with and without type 2 diabetes prior to coronary artery bypass graft surgery. PloS one, 15(8), e0234539.

Hoang, K., Abdo, T., Reinersman, J. M., Lu, R., Higuita NIA (2020). A case of invasive pulmonary mucormycosis resulting from short courses of corticosteroids in a well-controlled diabetic patient. (vol. 29, pp. 22-24). Medical mycology case reports.

Luis Velazco Davila, MD Vervoort, D., Velazco-Davila, L. D. (2020). Closing the gap by filling the gaps: Leveraging international partnerships to train the world's cardiac surgical workforce. (2nd ed., vol. 160, pp. e51-e52). The Journal of thoracic and cardiovascular surgery.

Grimes, A. D., Velazco Davila, L. D., Cross, A. M., LE Harville, 3rd (2020). Delayed Finding of Atrial Rupture Following Significant Blunt Force Trauma.

The American surgeon, 3134820933588.

Referral Information Pediatric Cardiac Surgery The Children's Hospital Heart Center 1200 N. Children's Ave, 2F Oklahoma City, OK 73104 Phone (405) 271-4411 Fax (405) 271-5190 Harold Burkhart, MD Yuki Nakamura, MD

Vascular Surgery OU Health Physicians General Surgery Clinic 825 NE 10th St, 4G Oklahoma City, OK 73104 Phone (405) 271-1400 Fax (405) 271-1407 Joshua Gierman, MD

Adult Cardiac Surgery OU Physicians - Valve Clinic 825 NE 10th St, 4G Oklahoma City, OK 73104 Phone (405) 271-4660 Fax (405) 271-4451 Lacey Harville, MD Luis Daniel Velazco Davila, MD

Thoracic Surgery OU Health Physicians Waterview Park 2607 SW 119th St, Ste B Oklahoma City, OK 73170

Thoracic Surgery Stephenson Cancer Center Thoracic Cancer Clinic 800 NE 10th St, 4500 Oklahoma City, OK 73104

VA Cardiac Clinic Oklahoma City VA Health Care System 921 NE 13th St Oklahoma City, OK 73104

Phone (405) 271-7987 Fax (405) 378-2012

Phone (405) 271-1632 Fax (405) 271-1630

Phone (405) 456-2637

Argenis Herrera, MD

Argenis Herrera, MD J. Matthew Reinersman, MD

Lacey Harville, MD Luis Daniel Velazco Davila, MD

Division of General Surgery, Trauma Surgery, Critical Care

Roxie Albrecht, MD Professor and Division Chief Vice Chair of Quality Improvement Trauma Medical Director

Clinical Faculty Trauma | Critical Care Roxie Albrecht, MD Celia Blair, MD Scott Blair, DO Amanda Celii, MD Alicia Cross, MD Ryan Kennedy, MD Jason Lees, MD

Burn Surgery Mary Margaret Brandt, MD

General Surgery Laura Fischer, MD Fernando Mier, MD Alexander Raines, MD

Cardiac Intensivist Frank Wood, MD

The Division of General Surgery, Trauma, Critical Care welcomes Dr. Fernando Mier. Dr. Mier joins us as an Assistant Professor from Sangre de Cristo Surgical Associates in Pueblo, Colorado.

He created and directed Parkview Medical Centers Metabolic and Bariatric Surgery Program. He specializes in minimally invasive solid organ and GI Surgery.

Dr. Frank Wood joins us as an Assistant Professor and Cardiac Intensivist from the University of Louisville. He joins both the Division of Cardiac, Thoracic, and Vascular Surgery as well as the Division of General Surgery / Trauma Surgery / Critical Care.

The division had many accomplishments in 2020. To start the year, the division was re-verified as a Level 1 Trauma Center (Adult & Pediatric) by the American College of Surgeons.

The division appeared in social media and news outlets.

Oklahoma Health News met with Laura Gamino, RN, MPH, Injury Prevention Coordinator for Trauma Services, Safe Kids OKC Metro Coalition Coordinator to talk about summer safety tips for staying active and keeping safe. Full video can be seen at https://www.facebook.com/OUHealth/videos/1380469712149149.

Dr. Maggie Brandt was interviewed by KOCO News regarding Firework Safety.

Full video can be seen at https://www.koco.com/article/expert-discusses-dangers-of-puttingon-your-own-fireworks-display/33170634.

In July 2020, OU Medicine leaders received notification that OU Medical Center had been named a recipient of the Silver Level Pathway to Excellence in Life Support Award; presented by ELSO Extracorporeal Life Support Organization. This award recognizes OU Medical Center's extracorporeal life support program, established according to ELSO guidelines, and represents significant achievement toward becoming an ELSO Center of Excellence. A minimum score of 500 is required for eligibility, with an average score of 593. Our score is 620, demonstrating that we are already ahead of the curve on the pathway to center of excellence. We are the only Adult ECMO center on the pathway at this time. Congratulations to all the members involved in the success of this program! Read more here: https://www.ouhealth.com/blog/2020/july/ou-health-life-suportprogram-achieves-reconit/#~M3q5N33

Ryan Kennedy, MD Co-Director Adult ECMO Services

The American College of Surgeons Committee on Trauma recently named Roxie Albrecht, MD, FACS, FCCN, as the recipient of its Regional Committee on Trauma Meritorious Service Award. The award recognizes outstanding contributions made in service to the committee. Albrecht was the region chief for Region VI from 2011 to 2017 and has served in a variety of leadership roles since 1998.

“I’m truly humbled, honored, and surprised by this award from the committee that I have so much admired and appreciated for its ongoing focus on quality patient outcomes, optimal patient outcomes, system development, and above all, injury and violence prevention,” Albrecht said.

“Working with the Committee on Trauma, and especially the verification review committee has been the highlight of my career. Thank you for your ongoing passion in these areas.”

Congratulations Dr. Albrecht!

Roxie Albrecht, MD Recipient RCOT Meritorious Service Award

New Hires Jason Lees, MD Awarded 2019-2020 Outstanding Faculty Award on behalf of Clinical Curriculum Subcommittee for recognizing excellence in teaching & dedication to medical students 2019-2020 Outstanding Teacher Award Amanda Celii, MD member of Mask Up Campaign

Fernando Mier, MD

Laura Fischer, MD Elected President of the Oklahoma State Chapter for ASMBS (American Society for Metabolic & Bariatric Surgery) Inducted as a new Fellow of the American College of Surgeons Oct 2019 Elected to the Global Affairs Committee for AAS (Association for Academic Surgeons) - 2year term December 2019 Ryan Kennedy, MD Co-Director Adult ECMO Services - OUMC named recipient of Silver Level Pathway to Excellence in Life Support Award, presented by the Extracorporeal Life Support Organization (ELSO) Alexander Raines, MD Recipient - Aesculapian Award - Faculty for "Excellence in teaching the clinical sciences" 1000 robotic cases completed by Edmond Robotic Team 2019-2020 Outstanding Teacher Award Quratulain (Anna) Sabih, MD Recipient of Outstanding Faculty Award by Dean's office 2019-2020 Outstanding Teacher Award

Frank Wood, MD

Awards & Recognition Roxie Albrecht, MD Recipient of Committee on Trauma Meritorious Service Award from the American College of Surgeons Mary-Margaret Brandt, MD Firework Safety KOCO Interview Peter Collister, MD 2019-2020 Outstanding Teacher Award

Research Amanda Celii, MD "Multicenter Trial- Current Management of Suspected Retained Common Bile Duct Stones in Gallstone Pancreatitis and Choledocholithiasis," -Sponsored by University of Oklahoma Health Science Center – 2020 "Predicting Delayed Operative Intervention in Patients with Blunt Small Bowel Trauma," -Sponsored by University of Oklahoma Health Science Center -2019 – Present

"Specific Transfer Feed Back Letter Affect Trauma in Rural Communities," -Sponsored by University of Oklahoma Health Science Center -2019 – Present "Diagnosis of Blunt Aortic Injury: Is Computed Topography Angiogram Necessary," Celii, A., Nichols, C., -Sponsored by University of Oklahoma Health Science Center -2018 – Present "Multicenter Small Bowel Injury Study," -Sponsored by University of Oklahoma Health Science Center -2018 – Present "Multicenter Trial- Rib Fracture Fixation Study," Sponsored by University of Oklahoma Health Science Center -2018 – Present

Grants Scott Blair, DO 1. Blair, S. G., Hanas, J. S. "Serum identification and phenotype assessment of traumatic brain injury and associated concussion disorders," -Sponsored by OU Cares, The University of Oklahoma (Institutional) -Total Direct Costs: $6500 -June 22, 2020 – Present 2. Principle Investigator "Traumatic Brain Injury: Mortality and Functional Outcomes."

– Present 3. Principal Investigator "Biomarkers in Acute Respiratory Distress Syndrome: Does ECMO alter Rage and Ang-2?," -Sponsored by Department of Surgery -Total Direct Costs: $5000 – Present Amanda Celii, MD 1. Celii, A. "Spinal Cord Injury Study," -Sponsored by University of Oklahoma Health Science Center -2018 - Present

Alisa Cross, MD 1. Principal Investigator "Resident Confidence and Operative Performance: Translating Procedural Workshops into the “Real Life” Operating Room," -Sponsored by University of Oklahoma Academy of Teaching Scholars - Total Direct Costs: $3500 - July 2016 – Present

2. Co-Project Lead (Rogers, C. Lead / Villanueva, R. Co-Lead) "Interprofessional Perioperative Education," -Sponsored by Interprofessional Educators & Practitioners Association (IEPA) -Total Direct Costs: $3970 - September 2019 - May 2020

Laura Fischer, MD 1. Co-Principle Investigator (Sparling, D Co-Principle Investigator/Olson, A CoPrinciple Investigator) "The role of CRISPLD2 in adipose function" -Sponsored by HHDC/PHF Grant -Contract Number: GFR00002923 -Total Direct Costs: $100,000.00 -July 1, 2019 - June 30, 2020

Jason Lees, MD 1. Lees, J., Berry, W. L. "The Roll of PDGF Signaling Mechanotransduction Nexus In the Development of Peritoneal Adhesions," -Sponsored by Oklahoma Science and Technology -Research and Development (OSTRaD) Board, State -Grant/Contract Number: HR20-131 -Current Funding (Total Cost per Year): $45000 -Total Direct Costs: $135000 -October 1, 2020 – Present 2. Co-Principal Investigator (Booth, K. K. Co-Principal Investigator) "Evaluation of surgical cases and resident independence by post graduate year," -Sponsored by Academy of Teaching Scholars -Total Direct Costs: $3625 - Present

Alexander Raines, MD 1. Raines, A.R. "Value-Based Medical Student Education Training Program" -Sponsored by DHHS/HRSA/Bureau of Health Workforce -July 1, 2020 - June 30, 2021

Presentations Scott Blair, DO Grimes, A., Stewart, K., Garwe, T., Blair, S. G., Sarwar, Z., Quang, C.Y., Kennedy, R., Celii, A., Lees, J., Albrecht, R., Cross, A. M., "Don't hold your breath expecting quantity or quality of life in the intubated elderly trauma patient", Western Association for Surgery and Trauma, Oral Presentation. 2020.

Blair, S. G., "The evaluation and workup of hernias and gallbladder disease, and when to refer to a surgeon", Family Medicine Grand Rounds, University of Health Sciences Center, Oklahoma City, Invited, Lecture. December 2, 2020.

Mary-Margaret Brandt, MD KOCO Interview - Firework Safety https://www.koco.com/article/expert-discussesdangers-of-putting-on-your-own-fireworksdisplay/33170634 Alisa Cross, MD Arthur, G.*, Cross, A. M., "Don't Hold Your Breath Expecting Quantity or Quality of Life in the Intubated Elderly Trauma Patient", Western Trauma Association, Sun Valley, ID, Accepted, Oral Presentation. February 25, 2020.

Rogers, C. E., Cross, A. M., Kosik, E. S., Lees, J., Schwier, N., "Effect of Inter-Professional Perioperative Simulation on Team Communication and Airway Fire Management", Oklahoma Nurses Association, Virtual Conference, Oral Presentation. October 1, 2020.

Rogers, C. E., Cross, A. M., Kosik, E. S., Lees, J., Schwier, N., "Academic Partnerships to Improve Clinical Outcomes in the Operating Room", Midwest Nursing Research Society, Virtual Conference, Oral Presentation. April 2020.

Ryan Kennedy, MD Grimes, A. D.*, Kennedy, R. O., "Differences in Rate of Intervention for Blunt Splenic Injury for Adolescent Trauma Patients between Adult and Combination Adult and Pediatric Trauma Centers", 79th Annual Meeting of AAST & Clinical Congress of Acute Care Surgery, American Association for the Surgery of Trauma, Accepted, Oral Presentation. September 19, 2020.

Grimes, A. D.*, Kennedy, R. O., "The Management of Acute Respiratory Distress Syndrome After Near Drowning and Low Voltage Electrocution", Midwest Surgical Association Annual Meeting, Midwest Surgical Association, Accepted, Oral Presentation.

August 2020.

Kennedy, R., "Trauma Associated Coagulopathy", SCABB 2020 Annual Meeting, South Central Association of Blood Banks, Invited, Lecture. August 28, 2020.

Kennedy, R., "COVID-19 and ECMO", Mustafa Kamal Pasha Lecture, Multan, Pakistan, Lecture. July 2020.

Grimes, A.*, Cross, A. M., Blair, S. G., Kennedy, R., "Don't Hold Your Breath Expecting Quantity or Quality of Life in the Intubated Trauma Patient", Western Trauma Association, Sun Valley, Idaho, Oral Presentation. February 2020.

Nichols, C. A.*, Kennedy, R. O., "Combined Liver, Colon and Pancreas Injuries complicated by Refractory Hypoxemia- Sometimes You Have to go with the Flow", Eastern Association for the Surgery of Trauma 33rd Annual Scientific Assembly, Eastern Association for the Surgery of Trauma, Orlando, Florida, Accepted, Platform Presentation. January 18, 2020.

Kennedy, R., "Extracorporeal Life Support for the Trauma Patient", Ascension St. John 11th Annual Trauma Symposium, Tulsa, Oklahoma, Lecture.

March 6, 2020.

Jason Lees, MD Rogers, C. E., Cross, A. M., Kosik, E. S., Lees, J., Schwier, N., "Effect of Inter-Professional Perioperative Simulation on Team Communication and Airway Fire Management", Health Professions Education Research Poster Presentation, Academy of Teaching Scholars, Virtual Conference, Poster.

October 16, 2020.

McGaha II, P., Craig, L. B., Stewart, K., Landmann, A., Fergeson, M. A., Lees, J., "Medical Student Specialty Preference: Does GRIT Matter or is it Something Else?", Health Professions Education Research Poster Presentation, Academy of Teaching Scholars, Poster. October 16, 2020.

Publications Roxie Albrecht, MD Gonzalez, R. A., Robbins, J. M., Garwe, T., Stewart, K. E., Sarwar, Z., Cross, A. M., Celii, A., Albrecht, R. (2020). Effect of Post-splenectomy Booster Vaccine Program on Vaccination Compliance in Trauma Patients. The American surgeon, 3134820956274.

Velmahos, G. C., Demetriades, D., Mahoney, E., Burke, P., Davis, K., Larentzakis, A., Fikry, K., El Moheb, M., Kovach, S., Schreiber, M., Hassan, M. O., Albrecht, R., Dennis, A. (2020). The worst-case scenario: Bridging repair with a biologic mesh in high-risk patients with very large abdominal wall hernias-a prospective multicenter study. Surgery.

Stewart, K., Garwe, T., Oluborode, B., Sarwar, Z., Albrecht, R. (2020). Association of Interfacility Helicopter versus Ground Ambulance Transport and in-Hospital Mortality among Trauma Patients.

Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors, 1-9.

Alisa Cross, MD Gonzalez, R. A., Robbins, J. M., Garwe, T., Stewart, K. E., Sarwar, Z., Cross, A. M., Celii, A., Albrecht, R. (2020). Effect of Post-splenectomy Booster Vaccine Program on Vaccination Compliance in Trauma Patients. The American surgeon, 3134820956274.

Grimes, A. D., Velazco Davila, L. D., Cross, A. M., LE Harville, 3rd (2020). Delayed Finding of Atrial Rupture Following Significant Blunt Force Trauma.

The American surgeon, 3134820933588.

Schellenberg, M., Brown CVR, Trust, M. D., Sharpe, J. P., Musonza, T., Holcomb, J., Bui, E., Bruns, B., Hopper, H. A., Truitt, M. S., Burlew, C. C., Inaba, K., Sava, J., Vanhorn, J., Eastridge, B., Cross, A. M., Vasak, R., Vercuysse, G., Curtis, E. E., Haan, J., Coimbra, R., Bohan, P., Gale, S., Bendix, P. G. (2020). Rectal Injury After Foreign Body Insertion: Secondary Analysis From the AAST Contemporary Management of Rectal Injuries Study Group. The Journal of surgical research, 247, 541546.

Scott Blair, DO Villanueva, R. D., Iovine, J. A., Blair, S. G., Kennedy, R., Paul, J. S. (2020). Empiric Antibiotic Therapy for Staphylococcus aureus Septic Shock: Is Vancomycin Indicated? Critical care medicine, 48(12), e1370e1371.

Laura Fischer, MD Worrest T, Cunningham A, Dewey E, Deloughery TG, Gilbert E, Sheppard BC, Fischer LE. Immune Thrombocytopenic purpura splenectomy in the context of new medical therapies. J Surg Res. 2020;245:643-8

Mary-Margaret Brandt, MD Hecht, J. P., Brandt, M. M., Wahl, W. L. (2020).

Early Chemoprophylaxis in Severely Injured Trauma Patients Reduces Risk of Venous Thromboembolism.

American Surgeon(On-line ahead of print).

Brandt, M. M., "Alcohol Misuse Is Associated with an Increased Risk of Postoperative Complication, Length of Stay and Hospital Charges for Patients Undergoing Major Foregut Resection", 77th Annual Meeting, Central Surgical Association, Meeting Cancelled due to COVID-19 Pandemic, Invited Discussant. 2020.

Hecht, J., Brandt, M. M., Wahl, W. L., "Early Chemoprophylaxis in Severely Injured Trauma Patients Reduces Risk of Venous Thromboembolism", 2020 Annual Meeting, Southeastern Surgical Congress, New Orleans, Accepted, Oral Presentation. 2020.

Ryan Kennedy, MD Kennedy, R. (2020). Empiric Antibiotic Therapy for Staphylococcus aureus Septic Shock: Is Vancomycin Indicated? Critical Care Medicine, 48(12), e1370e1371. https://journals.lww.com/ccmjournal/Fulltext/202 0/12000/Empiric_Antibiotic_Therapy_for_Staphyl ococcus.89.aspx Jason Lees, MD Lees, J. (2020). Journal of the Oklahoma State Medical Association. Journal of the Oklahoma State Medical Association.

Lees, J. (2020). Medical Student Specialty Preference: Does Grit Matter or is it Something Else?

Journal of the Oklahoma State Medical Association, 113(No. 3).

Referral Information General Surgery OU Health Physicians 825 NE 10th, 4G Oklahoma City, OK 73104

General Surgery OU Health Physicians Fountain Lake Multi-specialty 14101 N. Eastern Ave, C

Phone (405) 271-1400 Fax (405) 271-1403

Phone (405) 271-9551 Fax (405) 340-1555

Alexander Raines, MD Fernando Mier, MD

Alexander Raines, MD Fernando Mier, MD

General Surgery OU Health Physicians Med-Del Family Medicine 1212 S. Douglas Blvd Midwest City, OK 73130 Phone (405) 736-6811 Fax (405) 736-6863 Alexander Raines, MD

Trauma | Critical Care Surgery OU Health Physicians Sub-Specialty Building 700 NE 13th St Oklahoma City, OK 73104

Bariatric Surgery OU Health Physicians – Metabolic & Bariatric Surgery Clinic 1000 N. Lincoln Blvd, Ste 3200 Oklahoma City, OK 73104

Burn Surgery OU Health Physicians Sub-Specialty Building 700 NE 13th St Oklahoma City, OK 73104

Phone (405) 271-4700 Fax (405) 271-1407

Phone (405) 271-9448 Fax (405) 271-9449

Phone (405) 271-4700 Fax (405) 271-3919

Roxie Albrecht, MD Celia Blair, MD Scott Blair, MD Amanda Celii, MD Alicia Cross, MD Ryan Kennedy, MD Jason Lees, MD

Laura Fischer, MD Fernando Mier, MD

Mary Margaret Brandt, MD VA Surgery Oklahoma City VA Health Care System Phone (405) 405-456-3379 Ciaran O'Hare, MD Quratulain (Anna) Sabih, MD Peter Collister, MD

Division of Pediatric Surgery

Cameron Mantor, MD Professor & Division Chief Vice Chair of Operations Chief Medical Officer – The Children’s Hospital

Clinical Faculty Catherine Hunter, MD Jeremy Johnson, MD Cameron Mantor, MD Nikola Puffinbarger, MD Alex Ruiz, MD

The Division of Pediatric Surgery announces Dr. Catherine Hunter as the new holder of the Paula Milburn Miller CMRI/CHF Research Chair in Pediatric Surgery. The holder of this chair has the qualities of being a highly respected and nationally prominent pediatric surgeon. They are excellent clinical surgeons who will contribute further to the well-being of the children in the State of Oklahoma. In addition, they are accomplished in research and well published. The holder of the Milburn Chair exemplifies the tradition and excellence of Pediatric Surgery at the University of Oklahoma and will lead it into the future. Congratulations Dr. Catherine Hunter!

Dr. Catherine Hunter also received two OCASCR grants. This is from the Oklahoma Center for Adult Stem Cell Research.

Dr. Jeremy Johnson was awarded Outstanding Teacher Award for 2019-2020.

Dr. Alex Ruiz hosted 'Surgery for Pediatric #IBD' OKC and a local support group via zoom.

Awards & Recognition Catherine Hunter, MD Paula Milburn Miller CMRI/CHF Research Chair in Pediatric Surgery Academy of Teaching Scholars member Jeremy Johnson, MD 2019-2020 Outstanding Teacher Award Alessandra Landmann, MD Academy of Teaching Scholars member Cameron Mantor, MD 2020 Top Doc Alex Ruiz, MD Hosted Surgery for Pediatric with Kids Gut OKC and local peds support group

Grants Catherine Hunter, MD OCASCR Grant - Oklahoma Center for Adult Stem Cell Research - $120,000 2020-2021 OSCTR Pilot Grant - NIH-Oklahoma based grant $50,000

Presentations Catherine Hunter, MD Controversy in the classification of appendicitis and utilization of post-operative antibiotics - Oral Presentation Annual Academic Surgical Congress 2/1/2020 Echocardiogram reveals heart abnormalities in pediatric pectus carinatum - Oral Presentation Annual Academic Surgical Congress 2/1/2020 Necrotizing Enterocolitis: Anatomic Variation of Necrotizing Enterocolitis based on Gestational Age & Congenital Heart Disease - Oral Presentation Annual Academy Surgical Congress 2/1/2020 Pectus: an extensive overview of demographics and family history - Oral Presentation Annual Academic Surgical Congress 2/1/2020 Screening Echocardiography for Cardiac and Genetic Anomolies in Pediatric Pectus Deformities - Oral Presentation Annual Academic Surgical Congress 2/1/202

Jeremy Johnson, MD Neonatal thyrotoxicosis-induced pulmonary hypertension requiring ECMO - Poster Presentation The 36th Annual Children's National Symposium ECMO Meeting 1/1/2020 The Association of Essential Fatty Acid Status with Surgical Wound Complications - 15th Annual Academic Surgical Congress 2/6/2020

Publications Catherine Hunter, MD Port, E., Hunter, C. J., Buonpane, C., Vacek, J., Sands, L., Kujawa, S., Reynolds, M. (2020). Echocardiography Reveals Heart Abnormalities in Pediatric Pectus Carinatum. The Journal of surgical research, 256, 364367.

Hunter, C. J. (2020). An ethical framework for the allocation of resources in the event of shortages.

(2020). Balancing financial considerations and professional obligations. https://www.facs.org/covid19/newsletter/033120/ethics#framework Buonpane, C., Yuan, C. Y., Wood, D. R., Ares, G., Klonoski, S. C., Hunter, C. J. (2020). ROCK1 Inhibitor Stabilizes E-cadherin and Improves Barrier Function in Experimental Necrotizing Enterocolitis. American journal of physiology. Gastrointestinal and liver physiology.

Many, B. T., Rizeq, Y. K., Kwon, S., Vacek, J. C., Goldstein, S. D., Hunter, C. J., Ghomrawi, H., Abdullah, F. (2020).

Quantifying postoperative sleep loss associated with increased pain in children undergoing a modified Nuss operation. Journal of pediatric surgery.

Jeremy Johnson, MD McGaha, 2nd, P., Stewart, K., Garwe, T., Johnson, J. J., Sarwar, Z., Letton, R. W. (2020). Helicopter transport in pediatric trauma: A new methodology using Need for Surgeon Presence to evaluate the necessity of air transport. American journal of surgery, 220(2), 464-467.

McGaha II, P. K., Stewart, K., Garwe, T., Johnson, J. J., Sarwar, Z., Letton, R. W. (2020). Is it time for firearm injury to be a separate activation criteria in children?

An assessment of penetrating pediatric trauma using need for surgeon presence. American journal of surgery.

McGaha, 2nd, P., Garwe, T., Stewart, K., Sarwar, Z., Robbins, J., Johnson, J. J., Letton, R. W. (2020). Factors that predict the need for early surgeon presence in the setting of pediatric trauma. Journal of pediatric surgery, 55(4), 698-701.

Referral Information Pediatric Surgery The Children's Hospital 1200 N. Children's Ave, 2E Oklahoma City, OK 73104 Phone (405) 271-4357 Fax (405) 271-7161

Catherine Hunter, MD Jeremy Johnson, MD Cameron Mantor, MD Nikola Puffinbarger, MD Alex Ruiz, MD

Division of Plastic & Reconstructive Surgery

Suhair Maqusi, MD Associate Professor & Division Chief Plastic Surgery Fellowship Program Director

Clinical Faculty Guilherme Barreiro, MD Christian El Amm, MD Suhair Maqusi, MD Mark Mims, MD

The Division of Plastic and Reconstructive Surgery announce Dr. Suhair Maqusi as the new Division Chief. We also welcome a new Resident Program Coordinator, Magali Ochoa. We welcome two new surgeons, Dr. Guilherme Barreiro and Dr. Mark Mims, and two new fellows, Dr. Matthew Marr and Dr. Robert Nevitt. Plastic Surgery also created a new Plastic Surgery Interest Group for medical students. Plastic and Reconstructive Surgery created a new social media page on Instagram: @OU_PRS. CHECK THEM OUT! Dr. Guilherme Barreiro joins us as an Assistant Professor from the University of Pittsburgh School of Medicine. He has seven fellowships including an International Observership in Microsurgery and Lymphatic Supermicrosurgery, Microsurgery and Perforator Supermicrosurgery, and International Fellowship in Reconstructive Microsurgery and Gender Affirmation Surgery.

Dr. Mark Mims joins us as an Adjunct Assistant Professor from the University of North Carolina. He holds an appointment as an Assistant Professor in the Department of OtolaryngologyHead and Neck Surgery. He specializes in surgical and nonsurgical cosmetic and reconstructive techniques of the face, head and neck.

New Hires

Presentations Christian El Amm, MD Application of Augmented Reality in Surgery- Oral Presentation OU Academic Technology Expo 1/2020 Mark Mims, MD Modification of the Fasanella-Servat technique for involutional ptosis - Poster Presentation American Academy of Facial Plastic and Reconstructive Surgery Annual Meeting 9/2020 Approach to the nasal valve - Oral Presentation Grand Rounds OU Department of Otolaryngology 3/11/2020

Guilherme Barreiro, MD

Publications

Mark Mims, MD

Awards & Recognition Suhair Maqusi, MD Division Chief of Plastics & Reconstructive Surgery George Malliaras, MD Outstanding Teacher Award 2019-2020 Angel Farinas, MD Outstanding Teacher Award 2019-2020 Nasser Alamiri, MD Outstanding Teacher Award 2019-2020

Mark Mims, MD Mady LJ, Baddour K, Snyderman CH, Stapleton AL. Pediatric ectopic esthesioneuroblastoma: A case report and literature review. Otolaryngol Case Reports 2020; 16:100193 Mims MM, Leclerc AA, Smith LJ. Cricoid Chondronecrosis: Case Report and Review of Literature. Ann Otol Rhinol Laryngol. 2020 Jul;129(7):662-668. doi: 10.1177/0003489420904974. Epub 2020 Feb 18.

PMID: 32070112.

Ghodke A, Mims MM, Shockley WW, Clark JM. Suture Knot Externalization Modification of the Fasanella-Servat Technique for Involutional Ptosis.

Laryngoscope. 2020 Dec 10. doi: 10.1002/lary.29294. Epub ahead of print. PMID: 33300616.

Mims MM, Wang EW. Cost Analysis of Implants in the Surgical Repair of Orbital Floor Fractures. Ann Otol Rhinol Laryngol. 2020 May;129(5):456-461. doi: 10.1177/0003489419894358. Epub 2019 Dec 13.

PMID: 31833378.

Mims MM, Clark JM. The Butterfly Graft. Rhinoplasty Archive 2020. www.rhinoplastyarchive.com

Plastics Craniofacial Imaging Lab

The division of Plastic Surgery is happy to welcome Mohammad Abdul-Mukit to expand our Craniofacial Imaging Lab. Dr. Abdul-Mukit is completing his Ph.D. with the University of Oklahoma and brings his expertise in Computer Vision, Machine Learning, and Mixed-Reality Computing. He is currently working on Surgical Enhanced Visualization System (SEViS), a cuttingedge Augmented Reality and Virtual Surgical Planning system.

SEViS is the fruit of a research project sponsored by the Office of Vice-President for Research and the OU Foundation Craniofacial Fund. The first application, "IntraOp VSP" transfers pre-operative Virtual Planning for craniofacial surgery to facilitate and guide the execution phase. Future planned applications involve tumor resection (e.g. abdominal, pancreas, liver, etc), applications in surgical teaching (e.g. tracking surgeon/learner hand movements), and workflow optimization.

"Mukit", as he prefers to be called, joined us in early January 2021. Please stop by the division of Plastic Surgery on the 8th floor of Andrews Academic Tower to check out the equipment and see how it can be applied to your field. We are looking forward to as much input and discussions from residents and faculty as possible.

Christian El Amm, MD

Mohammad Abdul-Mukit,PhD

Referral Information

Plastic Surgery Clinic Adult Services OU Health Physicians 825 NE 10th St, 1G Oklahoma City, OK 73104

Children's General & Plastic Surgery The Children's Hospital 1200 N. Children's Ave, 2E Oklahoma City, OK 73104

Ear, Nose & Throat Clinic Adult Services OU Health Physicians 825 NE 10th St, 4C Oklahoma City, OK 73104

Phone (405) 271-4864 Fax (405) 271-2737

Phone (405) 271-4357 Fax (405) 271-7161

Phone (405) 271-1368 Fax (405) 271-8794

Guilherme Barreiro, MD Christian El Amm, MD Suhair Maqusi, MD Mark Mims, MD

Christian El Amm, MD Suhair Maqusi, MD

Mark Mims, MD

Division of Surgical Oncology

Ajay Jain, MD Professor and Division Chief Core Medical Director Stephenson Cancer Center

Clinical Faculty Breast Surgery Juan Claros-Sorto, MD Willliam Dooley, MD Omar Qutob, MD Teresa Shavney, MD Ronald Squires, MD

Colorectal Surgery Kristina Booth, MD Steven Carter, MD Gary D. Dunn, MD

Hepato-Pancreato-Biliary Surgery Morgan Bonds, MD Barish Edil, MD Ajay Jain, MD Katherine Morris MD

The Division of Surgical Oncology welcomes Dr. Morgan Bonds and Dr. Omar Qutob. Our Colorectal Program was one of two programs to be named on US News and World Report.

The surgical oncology group is expanding their network and are now seeing patients on the south side at Waterview Park.

Dr. Juan Claros-Sorto received a donation from the Kay Yow Cancer Fund. The Kay Yow Cancer Fund is a nonprofit organization dedicated to supporting women's cancer research. CONGRATULATIONS! Dr. Morgan Bonds joins us as an Assistant Professor from Virginia Mason Medical Center in Seattle, Washington. Her areas of interest include liver, biliary, and pancreas.

Dr. Omar Qutob joins us as a Clinical Instructor from the University of Oklahoma College of Medicine. He will begin a Breast Oncology Fellowship at Henry Ford Health Systems in 2021. CONGRATULATIONS!

New Hires

Awards & Recognition Kristina Booth, MD Recipient Dewayne D. Andrews MD Excellence in Teaching Award William Dooley, MD 2020 Top Doc Gary Dunn, MD 10 years of recognition with the University Barish Edil, MD Outstanding Teacher Award 2019-2020 2020 Top Doc

Morgan Bonds, MD

Steven Carter, MD Appointed Medical Director Stephenson Cancer Center Colorectal Program Juan Claros-Sorto, MD Appointed Medical Director Stephenson Cancer Center Breast Multidisciplinary Program 2020 American College of Surgeons Inductee Donation Recipient from the Kay Yow Cancer Fund Ajay Jain, MD Recipient Russell Postier Teaching Award for Excellence in Resident Education Recipient OU Physician Trauma Champ Award for assistance in severe liver/pancreas trauma Appointed Core Medical Director Stephenson Cancer Center Appointed a two-year term with the International Relations Committee of the American College of Surgeons Outstanding Teacher Award 2019-2020

Omar Qutob, MD

Grants Kristina Booth, MD 1. Principle Investigator Co-Investigator: Lees, J.; Lewis, S.; Garwe, T.; Stewart, K. "Evaluation of Surgical Cases and Resident Independence by Post Graduate Year" -Health Professions Education Research Grant -Sponsored by Academy of Teaching Scholars, The University of Oklahoma -July 1, 2020 - June 30, 2021

Ronald Squires, MD Co-Chair Promotion and Tenure Committee of the College of Medicine 25+ years of recognition with the University

Clinical Trial Ajay Jain, MD 1. Principle Investigator "A Randomized Phase 0 Study of High Dose Omeprazole in Patients with Pancreatic Cancer Planning to Undergo Surgical Therapy for Evaluating Changes of Biomarkers" GOAL: To understand whether alterations in tumor pH may alter autophagy and tumor survival mechanisms, making cancer more susceptible to chemotherapy.

Presentations Kristina Booth, MD The Effect of Body Mass Index on the Creation of an End-Colostomy in Rectal Cancer Patients- Platform Presentation American Society of Colon and Rectal Surgeons - Virtual 4/01/20 “Sexual dimorphisms within the tumor microenvironment of colorectal cancer.” - Oral Presentation The Stephenson Cancer Center Annual Research Symposium - 2/07/20 Steven Carter, MD “Sexual dimorphisms within the tumor microenvironment of colorectal cancer.” - Paper The Stephenson Cancer Center Annual Research Symposium - 2/07/20 Juan Claros-Sorto, MD Ascending to New Heights -Virtual Panel Discussion OU College of Medicine Office of Diversity, Inclusion and Community Engagement Hispanic Heritage Celebration 10/12/20 William Dooley, MD The impact of time to surgery on upstaging of stage I breast cancer patients -Poster Presentation SSO 2020 International Conference on Surgical Cancer Care - 3/27/20 A Prospective Study of Intraoperative Radiotherapy (IORT) for Early-Stage Breast Cancer -Poster Presentation SSO 2020 International Conference on Surgical Cancer Care - 3/26/20 Gary Dunn, MD “Sexual dimorphisms within the tumor microenvironment of colorectal cancer.” -Oral Presentation The Stephenson Cancer Center Annual Research Symposium - 2/07/20 Barish Edil, MD Surgical Advances in the treatment of Pancreas Cancer - Oral Presentation Grand Rounds University of Buffalo 2/01/20 Ajay Jain, MD Neoadjuvant therapy for vena cava sarcoma: A novel case and literature review of challenging tumors- E Poster Southwest Surgical Congress 1/20

Combined Liver, Colon and Pancreas Injuries complicated by Pulmonary Embolism- Sometimes You Have to go with the Flow - Oral Presentation 3rd Eastern Association for the Surgery of Trauma Annual Scientific Assembly 1/20 Katherine Morris, MD Granulocyte Colony Stimulating Factor and Colorectal Cancer: Turning a Clinical Question into a Translational Project -Oral Presentation Cancer Therapeutics Program Zoom 7/20 “Sex and BMI Over 35 Independently Predict Higher Odds of Mortality after Hepatectomy for Metastatic, but Not Primary Malignancy” -Oral Presentation The Americas Hepato-Pancreato-Biliary Association Annual Meeting 3/08/20 Sexual dimorphisms within the tumor microenvironment of colorectal cancer. -Paper Presentation The Stephenson Cancer Center Annual Research Symposium 2/07/20 "Obesity is an Independent Risk Factor for Mortality in Otherwise Healthy Patients Undergoing Major Hepatectomies" -Oral Presentation Annual Academic Surgical Congress 2/06/20 Clinical/Outcomes: Colorectal Oral Session I Moderator Annual Academic Surgical Congress 2/05/20 Ronald Squires, MD Maximizing the gift: One Opo’s experience maximizing the gift of organ donation by successfully increasing the number of Organs transplanted from non-brained donors -Oral Presentation 2020 American Transplant Congress 6/01/20 Multi-Organ Procurement Organization Review of the Impact of Reactive Anti-HCV And HCV NAT Results -Oral Presentation 2020 American Transplant Congress 6/01/20 The Hearth of the Matter: The Impact of the 2018 Heart Allocation Policy at a Single Organ Procurement Organization -Oral Presentation 2020 American Transplant Congress 6/01/20 What’s Lung got to do with it? The impact of the 2017 Lung Allocation Policy as a single organ procurement organization -Oral Presentation 2020 American Transplant Congress 6/01/20

Publications Morgan Bonds, MD van Roessel S, van Veldhuisen E, Klompmaker S, Janssen QP, Abu Hilal M, Alseidi A, Balduzzi A, Balzano G, Bassi C, Berrevoet F, Bonds M, Busch OR, Butturini G, Del Chiaro M, Conlon KC, Falconi M, Frigerio I, Fusai GK, Gagnière J, Griffin O, Hackert T, Halimi A, Klaiber U, Labori KJ, Malleo G, Marino MV, Mortensen MB, Nikov A, Lesurtel M, Keck T, Kleeff J, Pandé R, Pfeiffer P, Pietrasz D, Roberts KJ, Sa Cunha A, Salvia R, Strobel O, Tarvainen T, Bossuyt PM, van Laarhoven HWM, Wilmink JW, Groot Koerkamp B, Besselink MG; European-African Hepato-Pancreato-Biliary Association. Evaluation of Adjuvant Chemotherapy in Patients With Resected Pancreatic Cancer After Neoadjuvant FOLFIRINOX Treatment. JAMA Oncol.

2020 Nov 1;6(11):1733-1740. doi: 10.1001/jamaoncol.2020.3537. PMID: 32910170; PMCID: PMC7489392.

Moekotte AL, van Roessel S, Malleo G, Rajak R, Ecker BL, Fontana M, Han HS, Rabie M, Roberts KJ, Khalil K, White SA, Robinson S, Halimi A, Zarantonello L, Fusai GK, Gradinariu G, Alseidi A, Bonds M, Dreyer S, Jamieson NB, Mowbray N, AlSarireh B, Mavroeidis VK, Soonawalla Z, Napoli N, Boggi U, Kent TS, Fisher WE, Tang CN, Bolm L, House MG, Dillhoff ME, Behrman SW, Nakamura M, Ball CG, Berger AC, Christein JD, Zureikat AH, Salem RR, Vollmer CM, Salvia R, Besselink MG, Abu Hilal M; International Study Group on Ampullary Cancer (ISGACA) Collaborators, Aljarrah R, Barrows C, Cagigas MN, Lai ECH, Wellner U, Aversa J, Dickson PV, Ohtsuka T, Dixon E, Zheng R, Kowalski S, Freedman-Weiss M. Development and external validation of a prediction model for survival in patients with resected ampullary adenocarcinoma. Eur J Surg Oncol.

2020 Sep;46(9):1717-1726. doi: 10.1016/j.ejso.2020.04.011. Epub 2020 May 25.

PMID: 32624291.

Bonds M, Rocha FG. Neuroendocrine Tumors of the Pancreatobiliary and Gastrointestinal Tracts. Surg Clin North Am. 2020 Jun;100(3):635-648. doi: 10.1016/j.suc.2020.02.010. Epub 2020 Apr 1.

PMID: 32402306.

Gabrysz-Forget F, Bonds M, Lovett M, Alseidi A, Ghaderi I, Nepomnayshy D. Practicing on the Advanced Training in Laparoscopic Suturing Curriculum (ATLAS): Is Mastery Learning in Residency Feasible to Achieve Expert-Level Performance in Laparoscopic Suturing? J Surg Educ.

2020 Sep-Oct;77(5):1138-1145. doi: 10.1016/j.jsurg.2020.02.026. Epub 2020 Mar 14.

PMID: 32184062.

Bonds M, Rekman J, Rocha FG. Central pancreatectomy with pancreaticogastrostomy reconstruction: A brief report and video technique.

Am J Surg. 2020 May;219(5):828-830. doi: 10.1016/j.amjsurg.2020.01.037. Epub 2020 Feb 1.

PMID: 32057412.

Lof S, Korrel M, van Hilst J, Alseidi A, Balzano G, Boggi U, Butturini G, Casadei R, Dokmak S, Edwin B, Falconi M, Keck T, Malleo G, de Pastena M, Tomazic A, Wilmink H, Zerbi A, Besselink MG, Abu Hilal M; European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS). Impact of Neoadjuvant Therapy in Resected Pancreatic Ductal Adenocarcinoma of the Pancreatic Body or Tail on Surgical and Oncological Outcome: A PropensityScore Matched Multicenter Study. Ann Surg Oncol.

2020 Jun;27(6):1986-1996. doi: 10.1245/s10434019-08137-6. Epub 2019 Dec 17. PMID: 31848815; PMCID: PMC7210228.

Kristina Booth, MD Ryan G, Vyrostek S, Aminoff D, Booth K, Driesbach S, Fisher M, Gerberick J, Haanen M, Mullins C, Parker L, Schwarzer N. Importance of education and the role of the patient and family in the care of anorectal malformations. Semin Pediatr Surg. 2020 Dec;29(6):150990. doi: 10.1016/j.sempedsurg.2020.150990. Epub 2020 Nov 9. PMID: 33288139.

Fuchs ME, Halleran DR, Shin YJ, Sebastião Y, Weaver L, Ahmad H, Booth K, Ching CB, Levitt MA, Wood RJ, Dajusta DG. Anatomic factors predict urinary continence in patient with anorectal malformation. J Pediatr Urol. 2020 Oct;16(5):545.e1-545.e7. doi: 10.1016/j.jpurol.2020.06.011. Epub 2020 Jun 21.

PMID: 32798105.

Publications William Dooley, MD Fleming, R. M., Fleming, M. R., Dooley, W. C. (2020). FMTVDM Study Proposal: WID2H - Breast Trial. (Weight, Inflammation, Diet v Drug, Heart disease) – Breast Trial. Journal of Cardiology and Cardiovascular Medicine, 7(2), 072 to 078.

Fleming, R. M., Fleming, M. R., Dooley, W. C., Chaudhuri, T. K. (2020). The importance of differentiating between qualitative, semiquantitative, and quantitative imaging-close only counts in horseshoes.. European journal of nuclear medicine and molecular imaging.

Fleming, R. M., Fleming, M. R., Dooley, W. C., Chaudhuri, T. K. (2020). A Possible Solution for Women with Dense Breasts Using FMTVDM to Measure Changes in Breast Tissue. Acta Scientific Medical Sciences, 4(2), 01-04. https://www.actascientific.com/ASMS/pdf/apossible-solution-for-women-with-dense-breastsusing-fmtvdm-to-measure-changes-in-breasttissue.pdf Fabian CJ, Khan SA, Garber JE, Dooley WC, Yee LD, Klemp JR, Nydegger JL, Powers KR, Kreutzjans AL, Zalles CM, Metheny T, Phillips TA, Hu J, Koestler DC, Chalise P, Yellapu NK, Jernigan C, Petroff BK, Hursting SD, Kimler BF. Randomized Phase IIB Trial of the Lignan Secoisolariciresinol Diglucoside in Premenopausal Women at Increased Risk for Development of Breast Cancer. Cancer Prev Res (Phila). 2020 Jul;13(7):623-634. doi: 10.1158/19406207.CAPR-20-0050. Epub 2020 Apr 20. PMID: 32312713; PMCID: PMC7335358.

"A Prospective Single‐institution Study of Intraoperative Radiotherapy (IORT) for Early‐stage Breast Cancer." The Breast Journal. 27.3 (2021): 231-36. Web. Barish Edil, MD Hocker, J. R., Lerner, M. R., Lightfoot, S. A., Peyton, M. D., Thompson, J. L., Deb, S. J., Reinersman, M., Hanas, R. J., Postier, R. G., Edil, B. H., Burkhart, H. M., Hanas, J. S. (2020). Serum discrimination and phenotype assessment of coronary artery disease patents with and without type 2 diabetes prior to coronary artery bypass graft surgery. PloS one, 15(8), e0234539.

Edil, B. H., Luo, W., Li, M. (2020). Genomic and single cell sequencing facilitate the dissection of heterogeneity of pancreatic tumors. (1st ed., vol.

18, pp. 177). BMC medicine.

Moekotte, A. L., Rawashdeh, A., Asbun, H. J., Coimbra, F. J., Edil, B. H., Jarufe, N., Jeyarajah, D. R., Kendrick, M. L., Pessaux, P., Zeh, H. J., Besselink, M. G., Abu Hilal, M., Hogg, M. E. (2020). Safe implementation of minimally invasive pancreas resection: a systematic review. HPB : the official journal of the International Hepato Pancreato Biliary Association, 22(5), 637-648.

Liu, M., Zhang, Y., Yang, J., Cui, X., Zhou, Z., Zhan, H., Ding, K., Tian, X., Yang, Z., Fung, K.-M., Edil, B. H., Postier, R. G., Bronze, M., Fernandez-Zapico, M. E., Stemmler, M. P., Brabletz, T., Li, Y. P., Houchen, C. W., Li, M. (2020). ZIP4 Increases Expression of Transcription Factor ZE1 to Promote Integrin α3β1 Signaling and Inhibit Expression of the Gemcitabine Transporter ENT1 in Pancreatic Cancer Cells. Gastroenterology, 158(3), 679692.e1.

Asbun, H. J., Moekotte, A. L., Vissers, F. L., Kunzler, F., Cipriani, F., Alseidi, A., D'Angelica, M. I., Balduzzi, A., Bassi, C., Björnsson, B., Boggi, U., Callery, M. P., Del Chiaro, M., Coimbra, F. J., Conrad, C., Cook, A., Coppola, A., Dervenis, C., Dokmak, S., Edil, B. H., Edwin, B., Giulianotti, P. C., Han, H. S., Hansen, P. D., van der Heijde, N., van Hilst, J., Hester, C. A., Hogg, M. E., Jarufe, N., Jeyarajah, D. R., Keck, T., Kim, S. C., Khatkov, I. E., Kokudo, N., Kooby, D. A., Korrel, M., de Leon, F. J., Lluis, N., Lof, S., Machado, M. A., Demartines, N., Martinie, J. B., Merchant, N. B., Molenaar, I. Q., Moravek, C., Mou, Y. P., Nakamura, M., Nealon, W. H., Palanivelu, C., Pessaux, P., Pitt, H. A., Polanco, P. M., Primrose, J. N., Rawashdeh, A., Sanford, D. E., Senthilnathan, P., Shrikhande, S. V., Stauffer, J. A., Takaori, K., Talamonti, M. S., Tang, C. N., Vollmer, C. M., Wakabayashi, G., Walsh, R. M., Wang, S., Zinner, M. J., Wolfgang, C. L., Zureikat, A. H., Zwart, M. J., Conlon, K. C., Kendrick, M. L., Zeh, H. J., Hilal, M. A., Besselink, M. G. (2020). The Miami International Evidencebased Guidelines on Minimally Invasive Pancreas Resection. Annals of surgery, 271(1), 1-14.

Publications Qin R, Kendrick ML, Wolfgang CL, Edil BH, Palanivelu C, Parks RW, Yang Y, He J, Zhang T, Mou Y, Yu X, Peng B, Senthilnathan P, Han HS, Lee JH, Unno M, Damink SWMO, Bansal VK, Chow P, Cheung TT, Choi N, Tien YW, Wang C, Fok M, Cai X, Zou S, Peng S, Zhao Y. International expert consensus on laparoscopic pancreaticoduodenectomy. Hepatobiliary Surg Nutr. 2020 Aug;9(4):464-483. doi: 10.21037/hbsn20-446. PMID: 32832497; PMCID: PMC7423539.

Thomas A, Samykutty A, Gomez-Gutierrez JG, Yin W, Egger ME, McNally M, Chuong P, MacCuaig WM, Albeituni S, Zeiderman M, Li M, Edil BH, Grizzle WE, McMasters KM, McNally LR. Actively Targeted Nanodelivery of Echinomycin Induces Autophagy-Mediated Death in Chemoresistant Pancreatic Cancer In Vivo. Cancers (Basel). 2020 Aug 14;12(8):2279. doi: 10.3390/cancers12082279. PMID: 32823919; PMCID: PMC7464900.

Ajay Jain, MD Yepuri, N., Naous, R., Meier, A. H., Cooney, R. N., Kittur, D., Are, C., Jain, A., Dhir, M. (2020). A systematic review and meta-analysis of predictors of recurrence in patients with Solid Pseudopapillary Tumors of the Pancreas. HPB : the official journal of the International Hepato Pancreato Biliary Association, 22(1), 12-19.

Katherine Morris, MD Martinez, C., Fischer, L. E., Mihara, M. A., Edil, B. H., Morris, K. T. (2020). Minimally Invasive Pancreaticojejunostomy Techniques: a Literature Review. Annals of Pancreatic Cancer.

Urdaneta Perez MG, Garwe T, Stewart K, Sarwar Z, Morris KT. Obesity is an Independent Risk Factor for Mortality in Otherwise Healthy Patients After Hepatectomy. J Surg Res. 2020 Nov;255:50-57. doi: 10.1016/j.jss.2020.05.024. Epub 2020

Ray AL, Nofchissey RA, Khan MA, Reidy MA, Lerner MR, Wu X, Guo S, Hill SL, Weygant N, Adams SF, Castillo EF, Berry WL, Stout MB, Morris KT. The role of sex in the innate and adaptive immune environment of metastatic colorectal cancer. Br J Cancer. 2020 Aug;123(4):624-632. doi: 10.1038/s41416-020-0913-8. Epub 2020 May 26.

PMID: 32451467; PMCID: PMC7435180.

Ronald Squires, MD Stewart ZA, Shah SA, Formica RN, Kandaswamy R, Paramesh AS, Friedman J, Squires R, Cooper M, Axelrod DA. A call to action: Feasible strategies to reduce the discard of transplantable kidneys in the United States. Clin Transplant. 2020 Sep;34(9):e13990. doi: 10.1111/ctr.13990. Epub 2020 Jul 4. PMID: 32621660.

Referral Information Breast Cancer Clinic OU Health Physicians Fountain Lake Clinic 14101 N. Eastern Ave, C Edmond, OK 73013

Breast Cancer Clinic OU Health Physicians General Surgery Clinic 825 NE 10th St, 4G Oklahoma City, OK 73104

Breast Cancer Clinic OU Health Physicians Waterview Park 2607 SW 119th St, Ste B Oklahoma City, OK 73170

Phone (405) 271-9551 Fax (405) 340-1555

Phone (405) 271-1400 Fax (405) 271-1403

Phone (405) 271-7987 Fax (405) 378-2012

Teresa Shavney, MD

William Dooley, MD Teresa Shavney, MD

Juan Claros-Sorto, MD

Breast Cancer Clinic Stephenson Cancer Center General Surgery Clinic 800 NE 10th St, 2300 Oklahoma City, OK 73104

Colorectal Cancer Clinic OU Health Physicians Fountain Lake Clinic 14101 N. Eastern Ave, C Edmond, OK 73013

Colorectal Cancer Clinic OU Health Physicians General Surgery Clinic 825 NE 10th St, 4G Oklahoma City, OK 73104

Phone (405) 271-7126 Fax (405) 271-7129

Phone (405) 271-9551 Fax (405) 340-1555

Phone (405) 271-1400 Fax (405) 271-1403

Juan Claros-Sorto, MD Ronald Squires, MD

Steven Carter, MD

Kristina Booth, MD Steven Carter, MD Gary Dunn, MD

Colorectal Cancer Clinic OU Health Physicians Waterview Park 2607 SW 119th St, Ste B Oklahoma City, OK 73170

Colorectal Cancer Clinic Stephenson Cancer Center Colon & Rectal Cancer Clinic 800 NE 10th St, 4500 Oklahoma City, OK 73104

Hepato-Pancreatico-Biliary Stephenson Cancer Center Gastrointestinal Cancer Clinic 800 NE 10th St, 45000 Oklahoma City, OK 73104

Phone (405) 271-7987 Fax (405) 378-2012

Phone (405) 271-1632 Fax (405) 271-1630

Phone (405) 271-1632 Fax (405) 271-1630

Kristina Booth, MD

Kristina Booth, MD Steven Carter, MD Gary Dunn, MD

Morgan Bonds, MD Barish Edil MD Ajay Jain, MD Katherine Morris, MD

Division of Transplant Surgery

Tomasz Kozlowski, MD Professor & Division Chief

Clinical Faculty Narendra Battula, MD Tomasz Kozlowski, MD Elzbieta Rybicka-Kozlowska, MD

The Division of Transplant Surgery is our newest division. The division is lead by Dr. Tomasz Kozlowski. The transplant service line also consists of Dr. Elzbieta Rybicka-Kozlowska, transplant nephrologist, and Dr. Narendra Battula, transplant surgeon. We anticipate the arrival of two hepatologists to complete the transplant service line team.

Dr. Tomasz Kozlowski joins us as a Professor and Division Chief of Transplant Surgery. He graduated from medical school and completed a General, Vascular, and Transplant Surgery Training Program at the Medical University of Warsaw in Warszawa, Poland. He went on to complete a Transplant Surgery and Transplant Immunology Fellowship in Stockholm, Sweden, Fellowship in Transplant Surgery at Johns Hopkins University in Baltimore, MD. Dr. Kozlowski specializes in Liver, Pancreas, and Kidney transplants.

Dr. Elzbieta Rybicka-Kozlowska joins us as an Assistant Professor and Transplant Nephrologist. She graduated from medical school at the Medical University of Warsaw in Warszawa, Poland. She completed an Internal Medicine Residency at the University of Massachusetts Memorial Health Care and University Hospital and Medical Center in Stoney Brook, NY. She has completed a Nephrology Fellowship and an AST/ASN accredited transplant Nephrology Fellowship.

New Hires Dr. Narendra Battula joins us as an Assistant Professor. He graduated from Medical School at Manipal University in India.

Dr. Battula completed higher surgical training and a HepatoPancreato-Biliary & Adult/Pediatric Liver Transplantation Fellowship at University Hospitals Birmingham, United Kingdom. He is certified with the Royal College of Surgeons of England and Edinburgh and has an ASTS Approved Fellowship in Multi-Organ Transplantation (Liver, Kidney, Pancreas) from Ochsner Clinic, New Orleans.

Publications Narendra Battula, MD

Elzbieta Rybicka-Kozlowska, MD

Narendra Battula, MD Simonetti RG, Perricone G, Robbins HL, Battula NR, Weickert MO, Sutton R, Khan S. Portosystemic shunts versus endoscopic intervention with or without medical treatment for prevention of rebleeding in people with cirrhosis. Cochrane Database Syst Rev. 2020 Oct 22;10(10):CD000553. doi: 10.1002/14651858.CD000553.pub3. PMID: 33089892; PMCID: PMC8095029.

Chew CA, Iyer SG, Kow AWC, Madhavan K, Wong AST, Halazun KJ, Battula N, Scalera I, Angelico R, Farid S, Buchholz BM, Rotellar F, Chan AC, Kim JM, Wang CC, Pitchaimuthu M, Reddy MS, Soin AS, Derosas C, Imventarza O, Isaac J, Muiesan P, Mirza DF, Bonney GK. An international multicenter study of protocols for liver transplantation during a pandemic: A case for quadripartite equipoise. J Hepatol. 2020 Oct;73(4):873-881. doi: 10.1016/j.jhep.2020.05.023. Epub 2020 May 23. PMID: 32454041; PMCID: PMC7245234.

Referral Information

Transplant Surgery OU Health Transplant 940 NE 13th St Oklahoma City, OK 73104

Transplant Surgery Schusterman Center 4444 East 41st St Tulsa, OK 74135

Phone (405) 271-7498 Fax (405) 271-3919

Phone (918) 619-4400 Fax (405) 271-3919

Narendra Battula, MD Tomasz Kozlowski, MD Elzbieta Rybicka-Kozlowska, MD

Narendra Battula, MD Tomasz Kozlowski, MD Elzbieta Rybicka-Kozlowska, MD

Research

Katherine Morris, MD Associate Professor Vice Chair of Academic and Research Advancement

Research Faculty William Berry, Ph.D. Catherine Hunter, MD Min Li, Ph.D. Katherine Morris, MD Lacy McNally, Ph.D.

Outcomes Research Tabitha Garwe, MPH, Ph.D. Zoona Sarwar, MBBS, MS Kenneth Stewart, MPH, Ph.D.

Research Team David Alexander, LPN Study Coordinator

Asaleigh Cline

Medical Student Research Coordinator

Theresa Lander

Lead Regulatory Coordinator

Megan Lerner, HT (ASCP) Histology technician

Stephanie Mitchell, RN Lead Study Coordinator

The Department of Surgery at the OU College of Medicine aims to lead the region in clinical trials, high-impact science, and extramural grant funding because we know our patients need us to continue striving toward new discoveries.

Advancing patient care by contributing to high-quality research is a top priority for the Department of Surgery at the University of Oklahoma College of Medicine. To support surgeon-scientists in this effort, OU CARES was founded in 2018, bringing together people with a wide breadth of skills and a strong desire to help both current and future patients.

OU CARES supports our faculty and trainees in projects along the spectrum of translational science, from the bench to comparative effectiveness research. Our research support team includes funded bench scientists, epidemiologists, and biostatisticians with expertise in risk score development and big data sets, regulatory experts, 2 clinical research nurses, and an experienced histologist skilled at creating publicationready images. These services are available to all faculty and trainees at no cost.

Services Centralized support request - To assure rapid response to requests for assistance from OU CARES as we build our department’s database of projects and enhance collaboration, we have developed an easy online intake form. Once submitted, the members of our team will be notified of the areas you need support. A member of our team will be in contact with further instructions and to set up a meeting to discuss the project. You can request assistance at: https://redcap.ouhsc.edu/redcap/surveys/?s=8DCMJAC488

Industry/Investigator-Initiated Trial and Regulatory Compliance Support Our team is currently supporting 131 active IRBs and onboarding 4 new industry-sponsored trials which are estimated to bring in over $490,000 in research funds. We are able to assure regulatory compliance, support clinical trials, and negotiate industry trial budgets. Please send all information in regards to the trial to the email below. We review all trials every Friday and will reach out to the interested PI to discuss feasibility. Please send as much information as possible to ensure a quick turnaround: OUCares@ouhsc.edu. Let us help you from the beginning to get the best results!

Access to REDCAP To gain access to REDCap and to get a specially designed database for your project, please click on the link below and you should be able to log in with your OUHSC credentials. If you have any trouble, please email Asaleigh Cline (asaleighcline@ouhsc.edu). She will be in touch soon with further instructions. https://redcap.ouhsc.edu/

Public Outreach and Research Education Our Research Webpage allows us to highlight our services, team members, and your research accomplishments. At https://medicine.ouhsc.edu/Academic-Departments/Surgery/Research you will find the link to request help through RedCAP, the recent Surgery Department Pilot Grant Awardees, and subpages for bench research labs in our Department.

We are also planning to have an Abstract and grant submissions calendar soon. We are actively working on extending the impact of our Department’s research through social media outreach as well. Please send us your Presentations and Publications (bonus if you have a picture!) and a link to the publication so we can Tweet it out and increase your readership.

Asaleigh Cline serves as our point of contact for medical students interested in collaborating with Faculty and Residents within our Department. She can help assure the student has all the needed research training and assist with getting them Meditech, PACs, and EMR access for research projects. She matches students who do not yet have a research mentor by assessing their interests and available projects in the RedCAP database. Currently, 31 medical students have been matched with research projects in the last year! You can reach out to her at Asaleigh-Cline@ouhsc.edu.

Epidemiology, Statistics, Study Design, and Translational Project Development Dr. Garwe leads our Epidemiology and Statistics core facility and can match faculty and residents with the team member best suited for the project after receiving requests through the online RedCAP survey (https://redcap.ouhsc.edu/redcap/surveys/?s=8DCMJAC488). Her team can assist with study design, analysis of large national datasets such as NSQIP public user files, and power calculations. Request help early in your study design for best outcomes.

Dr. Berry is a funded scientist with wide expertise in advanced molecular biology techniques and mouse models of disease. Collaborative discussions regarding translational project ideas can also be requested at the above link.

First Annual Surgery Pilot Grant Awards

Awards & Recognition Tabitha Garwe, MPH, Ph.D. Awarded Oklahoma Center for the Advancement of Science Technology Grant (OCAST) - Geriatric Trauma Secondary Triage: Development and Validation of a Risk Score to Identify Patients Requiring Transfer to a Level I/II Trauma Facility William Berry, Ph.D. Awarded Oklahoma Center for the Advancement of Science Technology Grant (OCAST) - The Role of PDGF Signaling Mechanotransduction Nexus in the Development of Peritoneal Adhesions

Grants

Scott Blair, DO -Collaborating with Dr. Jay Hanas -study serum samples from Veterans in their project Title: Serum identification and phenotype assessment of traumatic brain injury and associated concussion disorders. -$6500 Arthur Grimes, MD -Collaborating with Drs. Elizabeth Hile, Gary Dunn, Kristina Booth, and Steven Carter -study frail colorectal cancer patients in their project -Title: Bolus prehab in frail colorectal cancer surgical patients. -$20,316.

Current Direct Grant Support -Department of Surgery for 2020 -$2,082,640 Direct funding requested -Department faculty (under current NIH review -$11,073,190

Publications “Optimized monoclonal antibody treatment against ELDT1 for GBM in a G55 xenograft mouse model.” Michelle Zalles, Nataliya Smith, Jadith Ziegler, Debra Saunders, Shannon Remarowski, Lincy Thomas, Rafal Gulej, Nadya Mamedova, Megan Lerner, Kar Ming Fung, Junho Chung, Kyusang Hwang, Junyeong, Jin, Graham Wiley, Chase Brown, James Battiste, Jonathan D Wren, Rheal A Towner. J Cell Mol Med. 2020 Jan 24(2):1736-1749. “lncRNA-PLACT1 sustains activation of NF-κB pathway through a positive feedback loop with IκBα/E2F1 axis in pancreatic cancer”. Ren X, Chen C, Luo Y, Liu M, Li Y, Zheng S, Ye H, Fu Z, Li M, Li Z, Chen R. Mol Cancer. 2020 Feb 21;19(1):35.

“Assessing bladder-hyper-permeability biomarkers, in vivo using molecularly-targeted MRI”. Rheal A Towner, Nataliya Smith, Debra Saunders, Megan Lerner, Beverly Greenwood-Van Meerveld, Robert E Hurst. Am J Nucl Med Mol Imaging 2020 Feb 25; 10(1):5765.

“Assessment of an scFv Antibody Fragment Against ELDT1 in a G55 Glioblastoma Xenograft Model”. Michelle Zalles, Nataliya Smith, Debra Saunders, Tanvi Saran, Lincy Thomas, Rafal Gulej, Megan Lerner, Kar-Ming Fung, Junho Chung, Kyusang Hwang, Junyeong Jin, James Battiste, Rheal A Towner. Transl Oncol 2020 Mar; 13(3):100737.

“Control of PTH secretion by the TRPC1 ion channel” Marta Onopiuk, Bonnie Eby, Vasyl Nesin, Peter Ngo, Megan Lerner, Caroline M Gorvin, Victoria J Stokes, Rajesh V Thakker, Maria Luisa Brandi, Wenhan Chang, Mary Beth Humphrey, Leonidas Tsiokas, Kai Lu. JCI Insight. 2020 Apr 23:5(8).

“Mosaic Mutant Analysis Identifies PDGFRα/PDGFRβ as Negative Regulators of Adipogenesis”. Chengy Sun, Hiromi Sakashita, Jang Kim, Zifeng Tang, G Michael Upchurch, Longbiao Yeo, William L Berry, Timothy M Griffin, Lorin E Olson.Cell Stem Cell 2020 May 7;26(5):707721.

“The role of sex in the innate and adaptive immune environment of metastatic colorectal cancer”. Anita L Ray, Robert A Nofchissey, Maaz A Khan, Megan R Reidy, Megan R Lerner, Xiangyan Wu, Shaoxuan Guo, Spencer L Hill, Nathaniel Weygant, Sarah F Adams, Eliseo F Castillo, William L Berry, Michael B Stout, Katherine T Morris. Br J Cancer 2020 Aug; 123(4) 624-632.

“Serum discrimination and phenotype assessment of coronary artery disease patients with and without type 2 diabetes prior to coronary bypass graft surgery”. James H Hocker, Megan Lerner, Stan A Lightfoot, Marvin D Peyton, Jess L Thompson, Subrato Deb, Mathew Reinersman, R. Jane Hanas, Russell G Postier, Barish H Edil, Harold M Burkhart, Jay Hanas. PLoSOne 2020 Aug 15(8).

“Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer”.Wang M, Liu J, Zhao Y, He R, Xu X, Guo X, Li X, Xu S, Miao J, Guo J, Zhang H, Gong J, Zhu F, Tian R, Shi C, Peng F, Feng Y, Yu S, Xie Y, Jiang J, Li M, Wei W, He C, Qin RMol Cancer. 2020 Aug 25;19(1):130.

“In vivo and ex vivo assessment of bladder hyper-permeability and using molecular targeted magnetic resonance imaging to detect clauding-2 in a mouse model for interstitial cystitis”.

Nataliya Smith, Debra Saunders, Megan Lerner, Michelle Zalles, Nadezda Mamedova, Daniel Cheong, Ehsan Mohammadi, Tian Yuan, Yi Luo, Robert E Hurst, Beverley Greenwood-Van Meerveld, Rheal A Towner. PLos One 2020 Oct 23;15 Griffith J, Berry WL. Myofibroblasts: Methods and Protocols.

Hinz B, Lagares D, editors. Contraction Measurements Using Three-dimensional Fibrillar Collagen Gel Lattices. In Press: Springer; 2020.

Education

Jason S. Lees, M.D. Vice Chair of Academic Affairs General Surgery Residency Program Director

Top Row (L>R): Mo Sidani, Chance Nichols, Paul McGaha II, Noah Rozich Bottom Row (L>R): Kiran Venincasa, Heidi Mahnken

New Student Leadership Amanda Celii, MD MS IV Director

Jeremy Johnson, MD MS III Clerkship Co-Director

Alexander Raines, MD MS III Co-Director

Resident Leadership Kristina Booth, MD

Associate Program Director

Alisa Cross, MD

Associate Program Director

This year, the Department of Surgery says goodbye to 6 residents. We wish them farewell as they begin the next chapter in their careers.

Mohamed Sidani, MD will be pursuing an Endocrinology Surgery fellowship at the University of Texas Southwestern Medical Center.

Chance Nichols, MD will be pursuing a Surgical Critical Care Fellowship at LA County.

Paul McGaha, II, MD will be pursuing a Pediatric Surgery Fellowship at Washington University in St. Louis.

Noah Rozich, MD will be pursuing a Surgical Oncology Fellowship at Aurora Health Care in Milwaukee, Wisconsin.

Kiran Venincasa, MD will enter private practice in the field of General Surgery.

Heidi Mahnken, MD will be pursuing a Surgical Critical Care Fellowship at the University of Texas Southwestern Medical Center.

CONGRATULATIONS TO YOU ALL!!!

RESIDENTS 2020 - 2021

PGY 4

Top Row (L>R): Maureen Mannas, Arthur Grimes, Rachael Palumbo, and Bailey Kleis Bottom Row (L>R): Aditi Jalla and Jackie Isabella

PGY 2

Top Row (L>R): Connor Wilkinson, Jacob O’Dell, and Chris Jeffery Bottom Row (L>R): Taylor Wilkinson, Joy Trimble and Lily Nguyen

PGY 3

Top Row (L>R): Tyler Leiva, Areej Sami, and Andrew Murphy Bottom Row (L>R): Andi Geddes, Lindsay Lindsey, and Taylor Martin

PGY 1

Top row (L>R): Paige Milhasky, Eric Skaggs, Chason Farnell, Wale Oluborode, and Michael Puccinelli Bottom row (L>R): Abby Rinchuso, Gabby Urdaneta, Jillian Harsha and Brooke Snyder.

Congratulations to the Department of Surgery on being recognized as national leaders in medical education. The surgery clerkship was ranked in the top 15 out of 145 medical schools, putting us in the >90%. This is an incredible accomplishment that takes the dedication of an entire department. Thank you for putting the effort into excelling at one of our department's core missions. Thank you to all the faculty and faculty leaders Dr. Jeremy Johnson, Dr. Alexander Raines and Dr. Jason Lees.

Thank you for your significant contribution to the intern boot camp curriculum. Your assistance was instrumental in both the patient care and procedural aspect of boot camp. Boot camp would not have been successful without the extra work of these residents: Dr. Sami Areej Dr. Lily Nguyen

Dr. Tyler Leiva Dr. Joy Trimble

Dr. Andrew Murphy Dr. Chance Nichols

Dr. Heidi Mahnken Dr. Arthur Grimes

The Accreditation Review Committee members recently met to make accreditation decisions and our institute was awarded re-accreditation for five years as a Comprehensive Education Institute.

Thank you to all involved.

Awards & Recognition Jaclyn Isabella, MD 2019-2020 Outstanding Teacher Award Aditi Jalla, MD 2019-2020 Outstanding Teacher Award Tyler Leiva, MD 2019-2020 Outstanding Teacher Award Lindsay Lindsey, MD 2019-2020 Outstanding Teacher Award Paul McGaha II, MD 2019-2020 Outstanding Teacher Award Academy of Teaching Scholars member Chance Nichols, MD 2019-2020 Outstanding Teacher Award Gold Humanism Honor Society member

Chance Nichols, MD 2019-2020 Outstanding Teacher Award Gold Humanism Honor Society member Jacob O'Dell 2019-2020 Outstanding Teacher Award Noah Rozich, MD 2019-2020 Outstanding Teacher Award Mohamed Sidani, MD 2019-2020 Outstanding Teacher Award Trauma Awards Outstanding Resident Kiran Venincasa, MD 2019-2020 Outstanding Teacher Award Taylor Wilkinson, MD 2019-2020 Outstanding Teacher Award

Presentations Andrea Geddes, MD Geddes AG, Ray AL, Nofchissey RA, Urdaneta Perez M, Khan MA, Aravindan S, Muralidharan J, Li M, Ahrendsen JT, Saunders AS, Dunn GD, Booth KK, Carter SN, Morris KT. “Sexual dimorphisms within the tumor microenvironment of colorectal cancer.” The Stephenson Cancer Center Annual Research Symposium, Oklahoma City O.K., February 7th 2020.

Paul McGaha II, MD Medical Student Specialty Preference: Does GRIT Matter or is it Something Else? McGaha II, Paul, MD, M.Sc.1; Craig, LaTasha B, MD2; Stewart, Kenneth, PhD1; Landmann, Alessandra, MD1; Fergeson, Mark, MD3; Lees, Jason, MD1 Chance Nichols, MD Nichols C, Kennedy R, Cross A, Jain A, Lees J. “Combined Liver, Colon and Pancreas Injuries complicated by Pulmonary EmbolismSometimes You Have to go with the Flow.”

Presented at 33rd Eastern Association for the Surgery of Trauma Annual Scientific Assembly in Orlando, Florida, January 14-18, 2020 Gabriela Urdaneta, MD Urdaneta MG, Stewart K, Garwe T, Sarwar Z, Morris KT. “Obesity is an Independent Risk Factor for Mortality in Otherwise Healthy Patients Undergoing Major Hepatectomies.”

Oral Presentation Annual Academic Surgical Congress 2020 And AHPBA for short oral presentation, Orlando, Fl, February 4-6, 2020.

Grants Samara Lewis, MD Kristina Booth, MD, Kenneth Stewart, Ph.D. -Looking at national SIMPL data and how assessment relates to case complexity -Academy of Teaching Scholars -$3600

Publications Paul McGaha II, MD Rozich NS, Landmann A, Bonds MM, Fischer L, Postier RG, Morris KT. “Tobacco smoking associated with increased anastomotic disruption following pancreaticoduodenectomy.”

Journal of Surgical Research, 2019 Jan; 233:199-206. doi: 10.1016/j.jss.2018.07.047.

Epub 2018 Aug 31. PMID: 30502248.

Greenbaum A, Alkhalili E, Rodriguez R, Caldwell K, O’Neill J, Munoz OE, Qeadan F, Myers O, Nir I, Morris KT. “Pancreatic Adenocarcinoma in New Mexico Native Americans: Disparities in Treatment and Survival.” J Health Care Poor Underserved.

2019; 30(2): 609-617. Doi: 10.1353/hpu.2019.0045. PubMed PMID: 31130540.

Rozich NS, Jones C, Morris KT. “Malnutrition, Frailty, and Sarcopenia in Pancreatic Cancer Patients: Assessments and Interventions for the Pancreatic Surgeon.” Annals of Pancreatic Cancer, 2019 Mar; 2. doi: 10.21037/apc.2019.02.01.

Rozich NS, Morris KT, Garwe T, Sarwar Z, Landmann A, Siems C, Jones A, Butler CS, McGaha PK, Axtman BC, Edil BH, Lees, JS .

“Blame it on the Injury: Trauma is a Risk Factor for Pancreatic Fistula Following Distal Pancreatectomy Compared to Elective Resection.” Journal of Trauma and Acute Care Surgery, 2019 Dec; 87(6): 1289-1300. doi: 10.1097/TA.0000000000002495.

In the Community

CIVITAS MINISTERIUM In 2020, the world saw itself waging a war against an enemy that was difficult to contain.

Governments and communities around the world were moving in concert to mobilize resources to slow the spread of Covid 19. Efforts such as requiring people to isolate themselves and to wear personal protective equipment were helping to mitigate the human costs of this disease, but the devastating effects that Covid 19 had on the economy forced governments to perform a delicate balancing act between protecting the public's health and stabilizing the economy. Loss of jobs, and consequently people's ability to provide for their families was reminiscent of the Great Depression and required financial measures of epic proportions.

Fortunately, communities were just as duty-bound as governments in ensuring everyone's safety and economic well-being. In spite of these dire times, communities reached out across physical, political, and economic borders to help each other. They rose to the occasion by doing their part through an outpouring of support from churches, organizations, and private citizens, bridging the gap between state assistance and the unmet needs of the many. The surge in giving and service is an example of how we continue to come together as a community in the wake of a global crisis.

The Latin term, civitas ministerium, which means community service, is a word embedded in our culture. It implies a duty to serve. Countless people, such as our doctors, are taking up the charge to help their communities combat this insidious disease by serving on the front lines in hospitals, research centers, and health care facilities. Our doctors embody the essence of civitas ministerium.

They are the fearless warriors who are worked tirelessly to treat infected patients, slow the spread of Covid 19 and develop effective treatments for patients.

Our doctors were prepared to take the necessary measures to protect their patients. They not only are experts in their respective fields but are trained in critical care and authorized to use their emergency privileges during times of crisis.

Doctors changed the way they did business in finding other ways to provide treatment by triaging patient care and scheduling more telemedicine visits, limiting the number of patients in hospital rooms, and having patients wait in their cars when they have office visits. These were all protocols to protect the public. Protocols in place at OU included requiring all staff to wear face masks and ensuring staff who care for cancer patients to wear N95 ventilators. Both types of PEs help prevent transmission in either direction, making it less likely to spread the disease. We also practiced hand hygiene and social distancing as we lived a 'new norm'.

Today, we have a vaccine. While not mandatory, it is highly encouraged to get vaccinated. As we begin to return to pre-Covid times, we must still use precaution around those who have not been vaccinated, where mask in large settings and practice hand hygiene and sanitizing. ~Yolanda Boyer

Dr. Raines & Team 1000 Robotic Cases

Justin Robbins, MD OU Class of 2020 being Hooded by Dr. Albrecht.

Dr. Claros - Kay Yow Cancer donation recipient

Dr. Jain Trauma Champ Award

Plastic Surgery Fellows

Dr. Jain - Russell Postier Award

Dr. Mohamed Sidani Trauma Resident Award

Dr. Claros becomes Fellow American College of Surgeons

laparoscopic appendectomy with Dr. Hunter

Dr. Raines - Aesculapian Award

Surgical Skills lab with Drs. Cross, Brandt and Quang

9th edition of #Trauma

open inguinal hernia with Dr. Cross

OU Cares

Get Connected https://www.oumedicine.com/department-of-surgery https://www.facebook.com/OUsurgery/ @OU_Surgery #OUsurgery or #OUtrauma ou_surgery or ou_prs

Giving

Surgeons at the University of Oklahoma Health Sciences Center are dedicated to excellence in education, research, and patient care. We appreciate the generous support of patients and their families, alumni, physicians, friends, and businesses.

Your gift can help improve a child’s health, award a resident a scholarship, or provide funds for research, equipment, computers, library materials, and more. Every gift we receive makes a difference, and we sincerely thank you for your generosity.

Development Office University of Oklahoma Health Sciences Center P.O. Box 26901 Oklahoma City, OK 73126 405-271-2300

If you would like to contribute an article, news item, or event notice for our newsletter, please email: jessica-capetillo@ouhsc.edu Next Issue December 2021