The Laboratory Report Summer/Fall 2016

The

Summer/Fall 2016

Laboratory Report A Publication of the Department of Pathology and Genomic Medicine

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The Department-Sponsored Cancer Biomarkers Conference II was an Outstanding Success

he Cancer Biomarkers Conference II (CBCII) hosted by the Department of Pathology and Genomic Medicine was held on September 10-11 in the Houston Methodist Research Institute. The event, which surpassed attendee expectations, featured 30 renowned speakers and panel moderators and was attended by almost 170 faculty, trainees, and other allied health professionals. Attendees hailed from 26 states in the U.S., and from Canada, China, Brazil, Mexico, and Saudi Arabia.

an average of 61 tweets per hour during the 1.5-day event.

There were more than 4 million views on Twitter during the actual event. Congratulations to Dr. Philip Cagle and all department faculty and trainees that participated and contributed to making the conference an overwhelming success! To see Twitter images and comments from attendees, please visit the confererence twitter page.

The speakers gave updates on biomarker testing for a range of cancers, including hematologic malignancies, melanoma, lung, gastrointestinal, and breast cancer. There were panel discussions on the utility of biomarkers in diagnosis and four keynote lectures on a variety of topics. The CBCII had a large presence on social media, and trended on Twitter with millions of views (“impressions�) while it was taking place. A total of 2,440 tweets were generated by 231 participants at

IN THIS ISSUE Department announces named chairs 2 Simmons donation for rapid virus detection

UPCOMING HOUSTON METHODIST MEETINGS (click banner to register)

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OCTOBER 8-9th Houston Methodist Research Institute

Congratulations to faculty and trainees 5 FDA approves liquid biopsy for lung cancer

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Meeting/alumni news

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Department welcomes new faculty and residents 10 Microgrant awards

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Department publications

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OCTOBER 20-22nd Houston Methodist Research Institute

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The Department of Pathology and Genomic Medicine Announces Four New Named Chairs

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he Department of Pathology and Genomic Medicine has the great pleasure to announce four new named chairs awarded to Drs. Philip Cagle, Dina Mody, Mary Schwartz, and Youli Zu. These physicians are honored with this distinction due to their outstanding and long-lasting contributions to Methodist pathology.

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hilip T. Cagle, MD, Medical Director of Pulmonary Pathology, was named to the S. Donald Greenberg Chair in Pathology. Dr. Cagle is a world-renowned pulmonary pathologist who joined Houston Methodist as an attending pathologist in 1987, and became director of pulmonary pathology in 2004. In addition to being Editor-in-Chief of Archives of Pathology and Laboratory Medicine, Dr. Cagle is on the editorial boards of CAP Today and Human Pathology. Dr. Cagle served as cochair and co-author of the College of American Pathologists (CAP) Lung Cancer Biomarker Guidelines, and chaired the CAP Lung Cancer Biomarker Reporting Template Workgroup. Dr. Cagle is the recipient of the CAP Distinguished Patient Care Award, the Houston Society of Clinical Pathologists (HSCP) Harlan J. Spjut Award, the CAP Pathologist of the Year Award, the Texas Society of Pathologists John J. Andujar Citation of Merit Award, and the America’s Top Doctors award for the past 6 years. Most recently, Dr. Cagle received the 2016 America’s Most Honored Professionals Award in Pathology, given to the top 1% in Pathology based on his receiving 132 recognitions since 2005. He is the author of over 150 peer-reviewed articles, editor of 15 textbooks, two electronic books, and editor for 3 book series.

“In the aggregate, these four colleagues have more than 100 years of tireless and extensive contributions to our Department, including outstanding accomplishments in patient care, training, and research.” - James M. Musser, MD, PhD, Chair

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ina Mody, MD, Medical Director of Cytopathology and Director of the Cytopathology Fellowship program, was named to the Ibrahim Ramzy Chair in Pathology. This year she received the Lansky Award of CAP for her leadership role in cytology. Previous leadership positions include President of the Texas Society of Cytology, Chair of the Scientific Program of the Houston Society of Clinical Pathologists, and President of the American Society of Cytopathology. In 2009, she received the Lifetime Achievement Award from CAP, and in 2010, she received the Harlan J. Spjut Award of HSCP and the Excellence in Education Award from the American Society of Cytopathology. Dr. Mody is the author of over 100 peerreviewed articles and 15 book chapters, and the editor of the recently published book Diagnostic Pathology: Cytopathology. Dr. Mody’s current research focuses on the application of HPV testing and genotyping in low- and high-risk populations, application of new imaging modalities in diagnostic cytopathology, and immunohistochemical and molecular testing in body fluid cytology.

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The Department Announces New Named Chairs (continued)

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ary Schwartz, MD, Medical Director, Anatomic Pathology, and Director, Surgical Pathology Fellowship program, was named to the Jack L. Titus Chair in Pathology. Dr. Schwartz is a recognized national leader in pathology education and an invaluable resource to all Methodist physicians. She has been named as one of the Best Doctors in America since 1996. In 2009, Dr. Schwartz received the Harlan J. Spjut Award from the HSCP for sustained scholarly achievements in pathology, and the CAP Spotlight Service Award for routinely going above and beyond to serve the community. Dr. Schwartz has received the CAP Lifetime Achievement Award, the American Society of Cytopathology Excellence in Education Award, and the Faculty Teaching Award from HMH Residency Programs (several times). Most recently, she was awarded the 2016 John W. Overstreet Award, which is given annually to a Houston Methodist physician who “exemplifies the best of the medical profession�. Dr. Schwartz is the author of over 130 peer-reviewed articles, web-based educational programs, editor of two electronic monographs, and many more. Her research interests include discovery and validation of tumor markers in breast and pancreatic cancers.

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EDITORIAL BOARDS

PUBLICATIONS

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ouli Zu, MD, PhD, Medical Director of Hematopathology and Director, Cancer Pathology Research Laboratory at HMRI, is named to the Hematopathology Research Chair in Pathology. Dr. Zu joined the Department of Pathology and Genomic Medicine at HMH in 2004, and was appointed Director of the Cancer Pathology Research Laboratory at HMRI and Medical Director of Hematopathology Section in the Department of Pathology and Genomic Medicine in 2010 and 2012, respectively. These combined positions enable him to directly apply his research findings to address clinical questions, and thus rapidly improve disease diagnosis and treatment. He is a prominent investigator in the field of aptamer-based clinical applications and nanotechnology. In particular, Dr. Zu was the first to demonstrate the utility of aptamers in multi-color flow cytometry analysis of patient samples, immunohistochemical staining of fixed tumor tissues, rapid detection of circulating tumor cells, specific tumor imaging, and in vivo drug delivery for targeted cancer therapy. Dr. Zu is the author of over 100 peer-reviewed articles. Dr. Zu is currently the principal or senior investigator on several research studies funded by NIH and the Cancer Prevention and Research Institute of Texas (CPRIT) that explore novel ways to detect, diagnose, and cure a variety of cancers.

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AWARDS/HONORS

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Virginia and L.E. Simmons Establish a Community-Wide Rapid Virus Detection Program to prevent continued spread and limit potential outbreaks.

“This is a unique undertaking that will have fast-acting consequences for viral monitoring, which is especially important now given the foothold Zika virus has gained in the U.S.,” stated Dr. Musser. The collaborating laboratories were able to rapidly launch Zika virus molecular diagnostics using support provided by this visionary award. The Virginia and L.E. Simmons Family Foundation program aims to promote excellent, collaborative, and interdisciplinary research programs, and has generously supported many programs in the Texas Medical Center and the Houston area.

Photo courtesy of Houston Methodist Foundation

SAVE THE DATE: DEPARTMENT OF PATHOLOGY AND GENOMIC MEDICINE GRAND ROUNDS: OCT 4TH, 8 AM RESEARCH INSTITUTE AUDITORIUM (R2-306) NGS in Clinical Practice: Interpretation and Applications Lynette M. Scholl, MD Assistant Professor, Pathology Harvard Medical School Associate Pathologist Brigham and Women’s Hospital

Dr. James Musser holding an image of the Chikungunya virus

Virginia Simmons holding an image of a coronavirus

L.E. Simmons holding an image of the Ebola virus

r. James Musser, Chair of the Department of Pathology and Genomic Medicine, and Dr. James Versalovic, Texas Children’s Hospital’s Pathologist-In-Chief and Director of the Microbiome Center, have established a collaboration for a community-wide virus detection and surveillance program thanks to generous support by Virginia “Ginny” and L.E. Simmons. By connecting Houston Methodist’s seven hospitals with Texas Children’s three hospitals, the program will cover the entire Houston metropolitan area and most of the outlying suburbs. The program is focused on rapidly identifying and tracking viral pathogens throughout the Houston area

Dr. James Versalovic holding an image of an influenza virus

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CONGRATULATIONS Dr. Matthew Cykowski Selected to Receive a Prestigious Clinician-Scientist Award

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r. Matthew Cykowski, a neuropathologist in the Department of Pathology and Genomic Medicine, was selected to receive a prestigious Clinician-Scientist Recruitment and Retention Award from the Houston Methodist Institute for Academic Medicine (IAM). This highly competitive program is designed to recognize and support recently recruited faculty members who show exceptional promise as clinician-scientists. Dr. Cykowski will study the molecular aspects of neurodegenerative diseases, with emphasis on amyotrophic lateral sclerosis (Lou Gehrig’s disease). Dr. Stanley Appel, Chair of the Department of Neurology, will mentor Dr. Cykowski, and Dr. Suzanne Powell, Medical Director of Neuropathology for the Department, will be closely involved in his continued professional development.

Dr. Cykowski joined the department in 2015 as a staff pathologist specializing in neuropathology. He completed a neuropathology fellowship (2013-2015) in the Department of Pathology and Genomic Medicine at Houston Methodist Hospital, and an anatomic pathology residency at the University of Oklahoma Health Science Center (2010-2013) where he served as the co-chief resident.

The Clinician-Scientist Program supports the IAM in advancing its core mission as an academic medical center. The three pillars of this mission are to: i) deliver integrated and high-quality patient care, ii) educate the next generation of health care providers and providers-in-training, and iii) perform research that expands our understanding of human disease to create new tools for improved health.

Dr. Matthew Cykowski

Dr. Tina Ipe named one of the American Society of Clinical Pathology’s “Top 40 Under 40”

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r. Tina Ipe, Associate Director of Transfusion Medicine, was named to the American Society of Clinical Pathology’s list of the “Top 40 Under 40” for 2016. This annual list compiles the top 40 clinical pathologists in the U.S. whose leadership and accomplishments are making a significant impact on the field.

Dr. Ipe joined Houston Methodist Hospital as Associate Medical Director of Transfusion Medicine in 2013, and was appointed Assistant Professor of Clinical Pathology and Genomic Medicine at Houston Methodist in 2015. Dr. Ipe received her MPH degree from Dartmouth Medical School,

Hanover, NH, and her MD degree from Medical College of Virginia, Richmond, VA. She then pursued a clinical pathology residency at the Hospital of the University of Pennsylvania, PA, and completed a fellowship in transfusion medicine at the same institution. Her research interests are in translational research in transfusion medicine, namely apheresis data analysis for improvement of patient outcomes. Congratulations Dr. Ipe! To see the entire list of winners, please visit the ASCP 40 Under 40 website.

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CONGRATULATIONS (cont) Dr. Youli Zu and Collaborator Receive Award from the Cancer Prevention and Research Institute of Texas (CPRIT)

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r. Youli Zu, Medical Director of Hematopathology, and Dr. Richard Willson, Huffington-Woestemeyer Professor of Chemical and Biomolecular Engineering and Professor of Biochemical and Biophysical Sciences at University of Houston, are lead investigators on the awarded project “An ultra-sensitive nanomagnetic sensor for the early detection of anaplastic large cell lymphoma.”

Dr. Zu specializes in aptamer nanotechnology, and has introduced innovative approaches in cancer diagnostics and clinical applications based on aptamers, a novel class of molecular recognition probes composed of small nucleic acid sequences. Dr. Zu also has extensive experience in cancer research, including anaplastic large T-cell lymphoma. For more information on Dr. Zu and his research, please visit his webpage.

Dr. Randy Olsen Speaks on Department’s CuttingEdge Approach to Clinical Pathology

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r. Randy Olsen, Medical Director of Molecular Diagnostics, presented the international plenary talk “Application of Next Generation Sequencing (NGS) in the Clinical Laboratory” at the 5th Molecular Microbiology Meeting 2016, which took place in Waterview, Bicentennial Park, Australia, on March 2-3, 2016.

Dr. Olsen and members of the Molecular Diagnostic Laboratory team have been responsible for developing many new tests that use NGS to greatly expedite and enhance cancer and microbiology diagnoses. These include tests to identify specific breast cancer mutations, both hereditary and acquired, and changes in genes linked to different leukemias. Most

recently, a test that uses NGS to identify mutations in 79 different genes that are associated with brain tumors, including glioblastoma multiforme and pituitary adenomas, was developed and is now in use. Knowing the underlying genetic mutation(s) responsible for the cancer can have significant influences on diagnosis, prognosis, and personalized therapy. For a list of all tests offered in the HMH Molecular Diagnostic Laboratory, please visit the test page. For questions about the Houston Methodist Diagnostic Laboratory, please contact Heather Hendrickson, Molecular Manager, at HLHendrickson@HoustonMethodist.org.

Dr. Randy Olsen

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GME FACULTY TEACHING AWARDS

AND MORE KUDOS: D r. Xin Yi, Co-Director of Clinical Chemistry, was recently elected to the National Academy of Clinical Biochemistry, and has a first-author publication in the inaugural issue of The Journal of Applied Laboratory Medicine. The article titled “High-Sensitivity Micro LC-MS/ MS Assay for Serum Estradiol without

Dr. Xin Yi

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Derivatization” was published in the July 2016 issue and focuses on the development and validation of a test to measure estradiol in patient samples.

Dr. Xin Yi completed her fellowship training in clinical chemistry at the University of Chicago School of Medicine after completing her PhD in clinical-bioanalytical chemistry at Cleveland State University in collaboration with Cleveland Clinic.

She joined the department in September 2015 as Associate Medical Director of Clinical Chemistry. She is a Diplomate of the American Board of Clinical Chemistry (DABCC) with broad expertise in clinical chemistry, endocrinology testing, therapeutic drug monitoring, toxicology, and clinical pharmacogenetics. “I learn from my colleagues every day and am always looking forward to new challenges,” said Dr. Yi.

The award is voted on by Houston Methodist residents and fellows, and SIX department faculty were recogized!

PATRICIA CHEVEZBARRIOS, MD APRIL EWTON, MD BLYTHE GORMAN, MD SUZANNE POWELL, MD MARY SCHWARTZ, MD

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r. David Cohen, a PGY4 in the Department, was selected as a 2016 CAP Foundation Leadership Development Award recipient. This award is designed to help defray travel expenses in connection with attending the CAP policy or resident meetings. Dr. Cohen was also elected to the CAP resident forum executive committee, the CAP subcommittee on graduate medical education, and a section editor for Archives of Pathology and Laboratory Medicine in clinical effectiveness and economics. Congratulations Dr. Cohen!

ARTHUR ZIESKE, MD

Dr. David Cohen

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The FDA Approves First Liquid Biopsy Test for Lung Cancer

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heterogeneity of solid tumor biopsy, allows real-time monitoring of disease progression and treatment effects, and can be performed on patients who may be too ill to undergo an invasive procedure.

Dr. Yimin Ge of the department’s pulmonary pathology group is leading our inhouse investigations into the development of liquid biopsy for lung cancer, and spoke on this topic at the Cancer Biomarkers Conference II in September.

To read the FDA press release, please visit the website. You can read the statement that the Pulmonary Pathology Society has issued regarding the liquid biopsy for lung cancer here.

Department of Pathology - 1983

he cobasÂŽ EGFR Mutation Test v2 is the first FDA-approved, blood-based genetic test that can detect epidermal growth factor receptor (EGFR) gene mutations. These mutations are present in 10-20% of non-small cell lung cancers (NSCLCs). This is a companion test to the cancer drug erlotinib, which is effective against cancers with these specific gene mutations. Lung cancer is the leading cause of cancer-related deaths among men and women in the U.S., and bloodbased diagnostics allow doctors to prescribe targeted medicines with a minimally invasive procedure. The benefits of liquid biopsy are numerous, and in addition to being non-invasive, it lacks the potential

Thirty-five years ago in July 1981, Drs. Dina Mody and Philip Cagle started as first-year pathology residents, with Drs. Luan Truong and Mary Schwartz as upper level residents. This year marks their 35th anniversary. Dr. Cagle shared this picture of the Department of Pathology from 1983 (the earliest he could find). You might also recognize Dr. Jamie Davis in the front row!

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MEETING NEWS The Inaugural Houston Methodist Lung Cancer Symposium will take place in the John F. Bookout Auditorium at HMRI on October 8-9, 2016. The symposium is presented by the Houston Methodist Department of Pathology and Genomic Medicine, the Houston Methodist Lung Center, the Houston Methodist Cancer Center, and is endorsed by CAP. Over the past year, there have been very significant advances in the diagnosis and treatment of lung cancer. These changes include the approval of lung cancer screening by the Centers for Medicare and Medicaid Services, advances in diagnosis of lung cancer by interventional pulmonology procedures, advances in thoracic surgery and radiation oncology, implementation of new targeted therapies for lung cancer, major revisions in the classification of lung cancer, and new advances in biomarker testing for targeted and immune therapies of lung cancer. Please visit the website for event details.

Pathobiology for Investigators, Students, and Academicians (PISA) is being hosted by Houston Methodist’s Department of Pathology and Genomic Medicine, and will take place on October 20-22, 2016, in the John F. Bookout Auditorium in the HMRI. This conference, titled Breakthroughs in Biology: From Underlying Pathogenesis to Translational Medicine, will be of interest to investigators and trainees from a spectrum of disciplines and attendance is encouraged. Department Chair Dr. James Musser will deliver the Rous-Whipple Award Lecture on Friday, October 21st. PISA is hosted by the American Society for Investigative Pathology (ASIP) and is aimed at providing attendees the most exciting and up-to-date concepts in molecular pathogenesis and translational medicine. Please visit the PISA website for event details and registration.

The Texas Society of Pathologists (TSP) will hold their 96th annual meeting at the Hyatt Regency Lost Pines in Bastrop, Texas, from January 20-22, 2017. Dr. Mary Schwartz, Medical Director of Surgical Pathology for our Department, will give the opening lecture titled “Current Controversies in Breast Pathology”. Other sessions will focus on the 2015 WHO classification of lung cancer, and informatics for the practicing pathologist. Please visit the TSP website for a complete schedule of events and to register.

ALUMNI NEWS Dr. JoElle Peterson, a former resident in the Department of Pathology and Genomic Medicine, received the Richard W. Leech Teaching Award from the residents at Oklahoma University at the resident graduation ceremony on June 9, 2016. This award is presented by the Department of Pathology residents to the faculty member who has best exemplified excellence in teaching.

Dr. Peterson is the Surgical Pathology Rotation Director at Oklahoma University, where she is in charge of resident education in surgical pathology. She completed her residency and fellowships in neuropathology and surgical pathology at HMH in June 2014. The subspecialties she practices include neuropathology, ophthalmic pathology, head and neck pathology, and pulmonary pathology. She teaches trainees in the departments of pathology, neurology and neurosurgery, as well as medical students, nursing students, and allied health students. “It is truly a privilege to be able to work with such fantastic residents. I am humbled by the honor they have given me with this award.” - JoElle Peterson, MD

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Department Welcomes New Faculty The Department of Pathology and Genomic Medicine welcomes four new faculty members. The department continues to grow to meet the increased patient volume resulting from Methodist’s ongoing expansion. Please extend a warm welcome to the following new faculty:

Dr. Ross Miller Dr. Ross Miller joined the department as a staff pathologist after completing fellowships in cytopathology (2014-2015) and surgical pathology (2015-2016) in the Department of Pathology and Genomic Medicine at HMH. He graduated first in his class from the Sanford School of Medicine at the University of South Dakota, Vermillion, SD, in May 2010, and completed a clinical and anatomic pathology residency (20102014) at the same institution. Dr. Miller’s research interests are focused on surgical pathology & cytopathology.

Dr. Tara Miller Dr. Tara Miller joined the department as a staff pathologist after completing a hematopathology fellowship in the Department of Pathology and Genomic Medicine at HMH and a clinical and anatomic pathology residency (2010-2013), serving as the chief resident in 2013, at the Sanford School of Medicine at the University of South Dakota, Sioux Falls, SD. She received her MD degree, also graduating first in her class, from the Sanford School of Medicine at the University of South Dakota, Vermillion, SD, in July 2009. Dr. Miller’s research interests are focused on hematopathology.

Dr. Eric Salazar Dr. Eric Salazar joined the Department as a staff pathologist after completing a fellowship in transfusion medicine (2015-2016), serving as the chief fellow for this period, in the Department of Pathology and Genomic Medicine at HMH. Prior to that, he completed a clinical pathology residency (2012-2015), serving as the chief resident for 2014-2015, in our Department. Dr. Salazar received his MD degree from the Weill Cornell Medical College in 2012 and his PhD in pharmacology from the Weill Cornell Graduate School of Medical Sciences while working at Rockefeller University. Dr. Salazar’s research interests are focused on transfusion medicine and immunology. Currently, he is actively involved in several collaborative research projects at HMH.

Dr. Jessica Thomas Dr. Jessica Thomas joined the Department as a staff pathologist after completing a combined clinical and anatomic pathology residency (2011-2015) and a clinical fellowship in molecular genetic pathology (2015-2016) in the Department of Pathology, Microbiology, and Immunology at Vanderbilt University Medical Center, Nashville, TN. She received her MD degree from the School of Medicine, Louisiana State University, New Orleans, LA, in 2011 and her PhD from the Department of Microbiology, Immunology, and Parasitology at the same institution. She earned her Master of Public Health (MPH, Health Education) degree from the University of Southern Mississippi, Hattiesburg, MS, in 2001.

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Welcome PGY1 Residents 2016-2017

Paloma Monroig-Bosque, MD, PhD University of Puerto Rico School of Medicine

Charlotte Myers, MD Wake Forest School of Medicine

Eric Rutledge, MD Baylor College of Medicine

Tiffany Sheu, MD Medical College of Georgia Georgia Regents University

Kent Swimley, MD The University of Texas School of Medicine, San Antonio

Jessica Tomsula, MD Creighton University School of Medicine

Department Awards Five New Microgrants The Department of Pathology and Genomic Medicine recently invited its faculty to submit research proposals for small, internal research grants. The Department’s microgrant program is designed to foster innovation and expansion of our clinical service. Each selected project receives a budget, and the work must start and finish within 3-4 months. The Department’s microgrant review committee is pleased to announce that five proposals have been chosen for funding. Congratulations to all five collaborating teams: The Utility of CD138 in the Differential Diagnosis of Ductal vs. Lobular Carcinoma of the Breast, awarded to Drs. David Alrahwan and Anna Richmond Development of Mass Spectrometry Quantitative Method for PD-L1 in FFPE NSCLC Samples, awarded to Drs. Nicola Dundas, Clayton Wilburn, Philip Cagle, Michael Deavers, Xin Yi, and Ping Wang Investigating Molecular Profiles in Indeterminate Thyroid FNA Specimens, awarded to Drs. Maren Fuller, Dina Mody, Anh Nguyen, Maja Udovcic, Richard Robbins, and Randall Olsen Morphologic and Molecular Characterization of Creutzfeldt Cell-Rich Glioblastoma, awarded to Drs. Leomar Y. Ballester, Matthew D. Cykowski, Suzanne Powell, Andreana Rivera, Gregory N. Fuller (MD Anderson Cancer Center), David Baskin, Gavin Britz, and Randall Olsen Ethnic Specific Genomic Instability Signatures as Breast Cancer Early Detection Markers, awarded to Drs. Susan Haley, Mary Schwartz, Jenny Chang, and Randa El-Zein

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PUBLICATIONS [Apr 2016 - Sept 2016]

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Abu Saleh WK, Tang GH, Ahmad H, Cohen M, Undemir C, Lansman SL, Reyes M, Barker CM, Kleiman NS, Reardon MJ, Ramlawi B. Vascular Complication Can Be Minimized with a Balloon-expandable, Re-collapsible Sheath in TAVR with a Self-expanding Bioprosthesis. Catheter Cardiovasc Interv. 2016 Jul;88(1):135-43. PMID: 26603266.

Akinfenwa PY, Chévez-Barrios P, Harper CA, Gombos DS. Late Presentation of Retinoblastoma in a Teen with Aicardi Syndrome.

Ocul Oncol Pathol. 2016 Apr;2(3):181-4. PMID: 27239462.

Arellano B, Hussain R, Miller-Little WA, Herndon E, Lambracht-Washington D, Eagar TN, Lewis R, Healey D, Vernino S, Greenberg BM, Stüve O. A Single Amino Acid Substitution Prevents Recognition of a Dominant Human Aquaporin-4 Determinant in the Context of HLA-DRB1*03:01 by a Murine TCR. PLoS One. 2016 Apr;11(4):e0152720. PMID: 27054574.

Arun BK, Gong Y, Liu D, Litton JK, Gutierrez-Barrera AM, Jack Lee J, Vornik L, Ibrahim NK, Cornelison T, Hortobagyi GN, HeckmanStoddard BM, Koenig KB, Alvarez RR, Murray JL, Valero V, Lippman SM, Brown P, Sneige N. Phase I Biomarker Modulation Study of Atorvastatin in Women at Increased Risk for Breast Cancer. Breast Cancer Res Treat. 2016 Jul;158(1):67-77. PMID: 27287781.

Auh QS, Chun YH, Melemedjian OK, Zhang Y, Ro JY. Peripheral Interactions Between Cannabinoid and Opioid Receptor Agonists in a Model of Inflammatory Mechanical Hyperalgesia. Brain Res Bull. 2016 Jul;125:211-7. PMID: 27450703.

Bachert BA, Choi SJ, LaSala PR, Harper TI, McNitt DH, Boehm DT, Caswell CC, Ciborowski P, Keene DR, Flores AR, Musser JM, Squeglia F, Marasco D, Berisio R, Lukomski S. Unique Footprint in the scl1.3 Locus Affects Adhesion and Biofilm Formation of the Invasive M3-Type Group A Streptococcus. Front Cell Infect Microbiol. 2016 Aug 31;6. [Epub ahead of print]. PMID: 27630827.

Badal SS, Wang Y, Long J, Corcoran DL, Chang BH, Truong LD, Kanwar YS, Overbeek PA, Danesh FR. miR-93 Regulates Msk2mediated Chromatin Remodelling in Diabetic Nephropathy. Nat Commun. 2016 Jun 28;7. [Epub ahead of print]. PMID: 27350436.

Bae Y, Izuhara K, Ohta S, Ono J, Hong GU, Ro JY, Park GH, Choi JH. Periostin and Interleukin-13 Are Independently Related to Chronic Spontaneous Urticaria. Allergy Asthma Immunol Res. 2016 Sep;8(5):457-60. PMID: 27334784.

Beres SB, Kachroo P, Nasser W, Olsen RJ, Zhu L, Flores AR, de la Riva I, Paez-Mayorga J, Jimenez FE, Cantu C, Vuopio J, Jalava J, Kristinsson KG, Gottfredsson M, Corander J, Fittipaldi N, Di Luca MC, Petrelli D, Vitali LA, Raiford A, Jenkins L, Musser JM. Transcriptome Remodeling Contributes to Epidemic Disease Caused by the Human Pathogen Streptococcus pyogenes. MBio. 2016 May;7(3):e00403-16. PMID: 27247229.

Cagle PT, Allen TC, Bernicker EH, Ge Y, Haque A, Barrios R. Impact of Recent Developments in Lung Cancer on the Practice of Pathology. Arch Pathol Lab Med. 2016 Apr;140(4):322-5. PMID: 27028391.

Cagle PT. Forging into the Future: Archives Continues to Grow. Arch Pathol Lab Med. 2016 Jun;140(6):500. PMID: 27232342.

Cao Z, Dahal RA, Wang P, Petersen JR, Okorodudu AO. Skin Rash and Microscopic Hematuria in a 10-Year-Old Caucasian Male.

Lab Med. 2016 May;47(2):158-62. PMID: 27069034.

Crumley SM, Pepper KL, Phan AT, Olsen RJ, Schwartz MR, Portier BP. Next-generation Sequencing of Matched Primary and Metastatic Rectal Adenocarcinomas Demonstrates Minimal Mutation Gain and Concordance to Colonic Adenocarcinomas. Arch Path Lab Med. 2016 Jun;140(6):529-35. PMID: 26536055.

Cykowski MD, Takei H, Baskin DS, Rivera AL, Powell SZ. Epithelial and Organ-related Marker Expression in Pituitary Adenomas.

Neuropathol. 2016 Aug;36(4):354-364. PMID: 26991787.

Cykowski MD, Takei H, Van Eldik LJ, Schmitt FA, Jicha GA, Powell SZ, Nelson PT. Hippocampal Sclerosis but Not Normal Aging or Alzheimer Disease Is Associated with TDP-43 Pathology in the Basal Forebrain of Aged Persons, J. Neuropathol Exp Neurol. 2016 May;75(5):397-407. PMID: 26971127.

DiNardo AR, Mace EM, Lesteberg K, Cirillo JD, Mandalakas AM, Graviss EA, Orange JS, Makedonas G. Schistosome Soluble Egg Antigen Decreases Mycobacterium tuberculosis-Specific CD4+ T-Cell Effector Function With Concomitant Arrest of Macrophage Phago-Lysosome Maturation. J Infect Dis. 2016 Aug;214(3):479-88. PMID: 27389351.

Divatia MK, Ro JY. Intraductal Carcinoma of the Prostate Gland: Recent Advances. Yonsei Med J. 2016 Sep;57(5):1054-62. PMID: 27401634.

Do H, Kumaraswami M. Structural Mechanisms of Peptide Recognition and Allosteric Modulation of Gene Regulation by the RRNPP Family of Quorum-Sensing Regulators. J Mol Biol. 2016 July;428(14):2793-804. PMID: 27283781.

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PUBLICATIONS [continued]

Driver BR, Portier BP, Mody DR, Deavers M, Bernicker EH, Kim MP, Teh BS, Santacruz JF, Kopas L, Munden RF, Cagle PT. Next-Generation Sequencing of a Cohort of Pulmonary Large Cell Carcinomas Reclassified by World Health Organization 2015 Criteria. Arch Pathol Lab Med. 2016 Apr;140(4):312-7. PMID: 26430808.

Eraso J, Olsen RJ, Beres SB, Kachroo P, Porter AR, Nasser W, Bernard PE, DeLeo F, Musser JM. Genomic Landscape of Intrahost Variation in Group A Streptococcus: Repeated and Abundant Mutational Inactivation of the fabT Gene Encoding a Regulator of Fatty Acid Synthesis. Infect Immun. 2016 Sep 6. [Epub ahead of print]. PMID: 27600505.

Fernandez-Moure JS, Van Eps JL, Peress L, Cantu C, Olsen RJ, Jenkins L, Cabrera FJ, Tasciotti E, Weiner BK, Dunkin BJ. Increased Use of Surgical Energy Promotes Methicillin-resistant Staphylococcus aureus Colonization in Rabbits Following Open Ventral Hernia Mesh Repair. Surg Endosc. 2016 Jul 7. [Epub ahead of print]. PMID: 27387174.

Gagetti P, Pasteran F, Martinez MP, Fatouraei M, Gu J, Fernandez R, Paz L, Rose WE, Corso A, Rosato AE. Modeling Meropenem Treatment, Alone and in Combination with Daptomycin, for KPC-Producing Klebsiella pneumoniae Strains with Unusually Low Carbapenem MICs. Antimicrob Agents Chemother. 2016 July;60(8):5047-50. PMID: 27216067.

Gal AA, Cagle PT. Naissance of the Archives of Pathology and Laboratory Medicine: A Critical Analysis of the January 1926, Volume 1 Issue. Arch Pathol Lab Med. 2016 Jul 11. [Epub ahead of print]. PMID: 27399212.

Green AL, Chintagumpala M, Krailo M, Langholz B, Albert D, Eagle R, Cockburn M, Chevez-Barrios P, Rodriguez-Galindo C. Correlation of Insurance, Race, and Ethnicity with Pathologic Risk in a Controlled Retinoblastoma Cohort: A Children’s Oncology Group Study. Ophthalmology 2016 Aug;123(8):1817-23. PMID: 27262763.

Hatzenbuehler LA, Starke JR, Graviss EA, Smith EO, Cruz AT. School-based Study to Identify and Treat Adolescent Students at Risk for Tuberculosis Infection. Pediatr Infect Dis J. 2016 Jul;35(7):733-8. PMID: 27078123.

Hong BK, Say EA, Chévez-Barrios P, Lee TC, Kim JW. Anterior Chamber Cholesterolosis in a Patient with Retinoblastoma. Digit J Ophthalmol. 2016 Mar;22(1):35-7. PMID: 27330481.

Hong M, Hao S, Patel KP, Kantarjian HM, Garcia-Manero G, Yin CC, Medeiros LJ, Lin P, Lu X. Whole-arm Translocation of der(5;17) (p10;q10) with Concurrent TP53 Mutations in Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS): A Unique Molecular-cytogenetic Subgroup. Cancer Genet. 2016 May;209(5):205-14. PMID: 27134073.

Islam AK, Knight RJ, Mayer WA, Hollander AB, Patel S, Teeter LD, Graviss EA, Saharia A, Podder H, Asham EH, Gaber AO. Intermediate-Term Outcomes of Dual Adult versus Single-Kidney Transplantation: Evolution of a Surgical Technique. J Transplant. 2016 July;2016. [Epub ahead of print]. PMID: 27478630.

Jousselin A, Manzano C, Biette A, Reed P, Pinho MG, Rosato AE, Kelley WL, Renzoni A. The Staphylococcus aureus Chaperone PrsA is a New Auxiliary Factor of Oxacillin Resistance Affecting Penicillin-Binding Protein 2A. Antimicrob Agents Chemother. 2016 March;60(3):1656-1666. PMID: 26711778.

Kim J, Jang SJ, Choi CM, Ro JY. Correlation of Histologic Subtypes and Molecular Alterations in Pulmonary Adenocarcinoma: Therapeutic and Prognostic Implications. Adv Anat Pathol. 2016 Sep;23(5):330-8. PMID: 27403614.

Lee EY, Yu E, Ro JY. The 14th Spring Seminar of the Korean Pathologists Association of North America. Arch Pathol Lab Med. 2016 May;140(5):394-6. PMID: 27128296.

Lee KS, Zhang Y, Asgar J, Auh QS, Chung MK, Ro JY. Androgen Receptor Transcriptionally Regulates μ-opioid Receptor Expression in Rat Trigeminal Ganglia. Neuroscience 2016 Sep;331:52-61. PMID: 27320211.

Liang L, Jiang Y, Chen JS, Niu N, Piao J, Ning J, Zu Y, Zhang J, Liu J. B7-H4 Expression in Ovarian Serous Carcinoma: A Study of 306 Cases. Hum Pathol. 2016 Jun;57:1-6. [Epub ahead of print]. PMID: 27349304.

Liu C, Pepper K, Hendrickson H, Cagle PT, Portier BP. Clinical Validation of a Novel Commercial Reverse Transcription-Quantitative Polymerase Chain Reaction Screening Assay for Detection of ALK Translocations and Amplifications in Non-Small Cell Lung Carcinomas. Arch Pathol Lab Med. 2016 Jul;140(7):690-3. PMID: 26599807.

Lockwood AM, Perez KK, Musick WL, Ikwuagwu JO, Attia E, Fasoranti OO, Cernoch PL, Olsen RJ, Musser JM. Integrating Rapid Diagnostics and Antimicrobial Stewardship in Two Community Hospitals Improved Process Measures and Antibiotic Adjustment Time. Infect Control Hosp Epidemiol. 2016 Apr;37(4):425-32. PMID: 26738993.

Makthal N, Gavagan M, Do H, Olsen RJ, Musser JM, Kumaraswami M. Structural and Functional analysis of RopB: A Major Virulence Regulator in Streptococcus pyogenes. Mol Microbiol. 2016 Mar;99(6):1119-33. PMID: 26714274.

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PUBLICATIONS [continued] Mariani AF, Malik AI, Chevez-Barrios P, Smith SV, Lee AG. Idiopathic Orbital Inflammation Associated with Relapsing Polychondritis.

Ophthal Plast Reconstr Surg. 2016 Mar 11. [Epub ahead of print]. PMID: 26974421.

Marks SM, Hirsch-Moverman Y, Salcedo K, Graviss EA, Oh P, Seaworth B, Flood J, Armstrong L, Armitige L, Mase S. Characteristics and Costs of Multidrug-resistant Tuberculosis in Patient Care in the United States, 2005-2007. Int J Tuberc Lung Dis. 2016 Apr;20(4):435-41. PMID: 26970150.

Miller RA, Cagle PT, Bernicker EH. First-Line Immune Therapy-Implications for Pathologists. Arch Pathol Lab Med. 2016 Aug;140(8):739-40. PMID: 27472228.

Miller RA, Miller TN, Cagle PT. PD-1/PD-L1, Only a Piece of the Puzzle. Arch Pathol Lab Med. 2016 Jul 11. [Epub ahead of print].

PMID: 27399213.

Modena BD, Kurian SM, Gaber LW, Waalen J, Su AI, Gelbart T, Mondala TS, Head SR, Papp S, Heilman R, Friedewald JJ, Flechner SM, Marsh CL, Sung RS, Shidban H, Chan L, Abecassis MM, Salomon DR. Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms That Correlate With Worse Long-Term Outcomes. Am J Transplant. 2016 Jul;16(7):1982-98. PMID: 26990570.

Morimoto D, Isu T, Kim K, Isobe M, Takahashi T, Ishida Y, Takei H, Morita A. Surgical Treatment for Post-traumatic Hemorrhage Inside a Filum Terminale Myxopapillary Ependymoma: A Case Report and Literature Review. Eur Spine J. 2016 March;25 Suppl 1:S239-44.

DOI 10.1007/s00586-016-4521-5.

Nelson PT, Trojanowski JQ, Abner EL, Al-Janabi OM, Jicha GA, Schmitt FA, Smith CD, Fardo DW, Wang WX, Kryscio RJ, Neltner JH, Kukull WA, Cykowski MD, Van Eldik LJ, Ighodaro ET. “New Old Pathologies”: AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS). J Neuropathol Exp Neurol. 2016 Jun;75(6):482-98. PMID: 27209644.

Okoye E, Euscher ED, Malpica A. Ovarian Low-grade Serous Carcinoma: A Clinicopathologic Study of 33 Cases With Primary Surgery Performed at a Single Institution. Am J Surg Pathol. 2016 May;40(5):627-35. PMID: 26900814.

Patel SJ, Suki WN, Loucks-DeVos J, Graviss EA, Nguyen DT, Knight RJ, Kuten SA, Moore LW, Teeter LD, Gaber LW, Gaber AO. Disparate Rates of Acute Rejection and Donor-specific Antibodies Among High-immunologic Risk Renal Transplant Sub-groups Receiving Antithymocyte Globulin Induction.Transpl Int. 2016 Aug;29(8):897-908. PMID: 27196395.

Raparia K, Aisner DL, Allen TC, Beasley MB, Borczuk A, Cagle PT, Capelozzi V, Dacic S, Hariri LP, Kerr KM, Lantuejoul S, MinoKenudson M, Rekhtman N, Roden AC, Roy-Chowdhuri S, Sholl L, Smith ML, Thunnissen E, Tsao MS, Yatabe Y. Transbronchial Lung Cryobiopsy for Interstitial Lung Disease Diagnosis: A Perspective From Members of the Pulmonary Pathology Society. Arch Pathol Lab Med. 2016 Jul 21. [Epub ahead of print]. PMID: 27441784.

Reynolds CL, Zhang S, Shrestha AK, Barrios R, Shivanna B. Phenotypic Assessment of Pulmonary Hypertension Using High Resolution Echocardiography is Feasible in Neonatal Mice with Experimental Bronchopulmonary Dysplasia and Pulmonary Hypertension: A Step Toward Preventing Chronic Obstructive Pulmonary Disease. Int J Chron Obstruct Pulmon Dis. 2016 Jul;11:1597-605. PMID: 27478373.

Rhim JH, Luo X, Gao D, Xu X, Zhou T, Li F, Wang P, Wong ST, Xia X. Cell Type-dependent Erk-Akt Pathway Cross-talk Regulates the Proliferation of Fetal Neural Progenitor Cells. Sci Rep. 2016 May;6:26547. PMID: 27211495.

Roy-Chowdhuri S, Aisner DL, Allen TC, Beasley MB, Borczuk A, Cagle PT, Capelozzi V, Dacic S, da Cunha Santos G, Hariri LP, Kerr KM, Lantuejoul S, Mino-Kenudson M, Moreira A, Raparia K, Rekhtman N, Sholl L, Thunnissen E, Tsao MS, Vivero M, Yatabe Y. Biomarker Testing in Lung Carcinoma Cytology Specimens: A Perspective From Members of the Pulmonary Pathology Society. Arch Pathol Lab Med. 2016 Apr 15. [Epub ahead of print]. PMID: 27081878.

Scharn CR, Collins AC, Nair VR, Stamm CE, Marciano DK, Graviss EA, Shiloh MU. Heme Oxygenase-1 Regulates Inflammation and Mycobacterial Survival in Human Macrophages during Mycobacterium tuberculosis Infection. J Immunol. 2016 Jun;196(11):4641-9.

PMID: 27183573.

Seger C, Shipkova M, Christians U, Billaud EM, Wang P, Holt DW, Brunet M, Kunicki PK, Pawinski T, Langman LJ, Marquet P, Oellerich M, Wieland E, Wallemacq P. Assuring the Proper Analytical Performance of Measurement Procedures for Immunosuppressive Drug Concentrations in Clinical Practice: Recommendations of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Immunosuppressive Drug Scientific Committee. Ther Drug Monit. 2016 Apr;38(2):170-89. PMID: 26982493.

Selber JC, Chang EI, Clemens MW, Gaber L, Hanasono MM, Klebuc M, Skoracki RJ, Trask T, Yu P, Gaber AO. Simultaneous Scalp, Skull, Kidney, and Pancreas Transplant from a Single Donor. Plast Reconstr Surg. 2016 Jun;137(6):1851-61. PMID: 27219240.

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PUBLICATIONS [continued]

Sholl LM, Aisner DL, Allen TC, Beasley MB, Borczuk AC, Cagle PT, Capelozzi V, Dacic S, Hariri L, Kerr KM, Lantuejoul S, Mino-Kenudson M, Raparia K, Rekhtman N, Roy-Chowdhuri S, Thunnissen E, Tsao MS, Yatabe Y; Programmed Death Ligand-1 Immunohistochemistry-A New Challenge for Pathologists: A Perspective From Members of the Pulmonary Pathology Society. Arch Pathol Lab Med. 2016 Apr;140(4):341-4. PMID: 26780537.

Sholl LM, Aisner DL, Allen TC, Beasley MB, Cagle PT, Capelozzi VL, Dacic S, Hariri LP, Kerr KM, Lantuejoul S, Mino-Kenudson M, Raparia K, Rekhtman N, Roy-Chowdhuri S, Thunnissen E, Tsao M, Vivero M, Yatabe Y. Liquid Biopsy in Lung Cancer: A Perspective From Members of the Pulmonary Pathology Society. Arch Pathol Lab Med. 2016 Aug;140(8):825-9. PMID: 27195432.

Song Y, Wang Y, Qi W, Li Y, Xuan J, Wang P, Qin L. Integrative Volumetric Bar-chart Chip for Rapid and Quantitative Point-of-care Detection of Myocardial Infarction Biomarkers. Lab Chip. 2016 Aug;16(15):2955-62. PMID: 27396992.

Soto E, Marchi S, Beierschmitt A, Kearney M, Francis S, VanNess K, Vandenplas M, Thrall M, Palmour R. Interaction of Non-human Primate Complement and Antibodies with Hypermucoviscous Klebsiella pneumoniae. Vet Res. 2016 March;47(40). [Epub ahead of print]. PMID: 26951091.

Swan JT, Ashton CM, Bui LN, Pham VP, Shirkey BA, Blackshear JE, Bersamin JB, Pomer RM, Johnson ML, Magtoto AD, Butler MO, Tran SK, Sanchez LR, Patel JG, Ochoa RA Jr, Hai SA, Denison KI, Graviss EA, Wray NP. Effect of Chlorhexidine Bathing Every Other Day on Prevention of Hospital-Acquired Infections in the Surgical ICU: A Single-Center, Randomized Controlled Trial. Crit Care Med. 2016 Oct;44(10):1822-32. PMID: 27428384.

Thrall MJ. Effect of Lower Anogenital Squamous Terminology Recommendations on the Use of p16 Immunohistochemistry and the Proportion of High-Grade Diagnoses in Cervical Biopsy Specimens. Am J Clin Pathol. 2016 Apr;145(4):524-30. PMID: 27124943.

Vinh D, Haley SL, Ongkasuwan J. A Laryngeal Lesion. JAMA Otolaryngol Head Neck Surg. 2016 April;142(4):399-400. PMID: 26967904.

Wang S, Joseph J, Diatchenko L, Ro JY, Chung MK. Agonist-dependence of Functional Properties for Common Non-synonymous Variants of Human Transient Receptor Potential Vanilloid 1. Pain 2016 Jul;157(7):1515-24. PMID: 26967694.

Wen J, Tao W, Hao S, Iyer SP, Zu Y. A Unique Aptamer-drug Conjugate for Targeted Therapy of Multiple Myeloma. Leukemia 2016 April;30(4):987–91. PMID: 26242462.

Xu-Monette ZY, Deng Q, Manyam GC, Tzankov A, Li L, Xia Y, Wang XX, Zou D, Visco C, Dybkær K, Li J, Zhang L, Liang H, MontesMoreno S, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huh J, Ponzoni M, Ferreri AJ, Parsons BM, Møller MB, Wang SA, Miranda RN, Piris MA, Winter JN, Medeiros LJ, Li Y, Young KH. Clinical and Biologic Significance of MYC Genetic Mutations in De Novo Diffuse Large B-cell Lymphoma. Clin Cancer Res. 2016 Jul;22(14):3593-605. PMID: 26927665.

Xu-Monette ZY, Zhang S, Li X, Manyam GC, Wang XX, Xia Y, Visco C, Tzankov A, Zhang L, Montes-Moreno S, Dybkaer K, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huh J, Ponzoni M, Ferreri AJ, Zhao X, Møller MB, Parsons BM, Winter JN, Piris MA, Medeiros LJ, Young KH. p63 Expression Confers Significantly Better Survival Outcomes in High-risk Diffuse Large B-cell Lymphoma and Demonstrates p53-like and p53-Independent Tumor Suppressor Function. Aging 2016 Feb;8(2):345-65.

PMID: 26878872.

Yi X, Leung EKY, Bridgman R, Koo S, Yeo K-TJ. High-Sensitivity Micro LC-MS/MS Assay for Serum Estradiol without Derivatization. J Appl Lab Med. 2016 Jul;1(1):14-24. DOI:10.1373/jalm.2016.020362.

Yoo SH, An S, Kim KR, Ro JY, Song JS. Clear Cell Atypical Fibroxanthoma Arising from Vaginal Stump: A Case Report from Unusual Location with a History of Radiation Therapy. Int J Clin Exp Path. 2016 March:9(3):4049-4054.

Zhou H, Mody RR, Luna E, Armylagos D, Xu J, Schwartz MR, Mody DR, Ge Y. Clinical Performance of the Food and Drug Administration-Approved High-risk HPV Test for the Detection of High-grade Cervicovaginal Lesions. Cancer Cytopathol. 2016 May;124(5):317-23. PMID: 26774025.

Zhou J, Chang L, Guan Y, Yang L, Xia X, Cui L, Yi X, Lin G. Application of Circulating Tumor DNA as a Non-Invasive Tool for Monitoring the Progression of Colorectal Cancer. PLoS One. 2016 Jul;11(7):e0159708. PMID: 27459628.

Zhou Y, Morgan ML, Almarzouqi SJ, Chevez-Barrios P, Lee AG. Apical Orbital Aspergillosis Complicating Giant Cell Arteritis. J Neuroophthalmol. 2016 Jun;36(2):159-63. PMID: 26835662.

Zhu L, Olsen RJ, Horstmann N, Shelburne SA, Fan J, Hu Y, Musser JM. Intergenic Variable-Number Tandem-Repeat Polymorphism Upstream of rocA Alters Toxin Production and Enhances Virulence in Streptococcus pyogenes. Infect Immun. 2016 Jun;84(7):208693. PMID: 271410.

THE LABORATORY REPORT is a publication of the Houston Methodist Department of Pathology and Genomic Medicine Editor-in-Chief April Ewton, MD

Editorial Committee Hazel Awalt, MD Claudia Molina, MD Seema Mullick, MD Thu Ngo, MD Steven Shen, MD, PhD

Editorial Coordinator Kathryn Stockbauer, PhD Department Chair James M. Musser, MD, PhD

Houston Methodist Hospital Mark Vassallo, MSN, RN Manuel Hinojosa, MHA