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Core Director: Xuewu Liu, PhD

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NANOENGINEERING CORE ROOM R8-412, HOUSTON METHODIST RESEARCH INSTITUTE

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The Nanoengineering core develops and produces state-of-the-art silicon-based bio-nanotechnology using microfabrication techniques. Scalability, precision, and reproducibility are characteristics of the silicon microfabrication processes which are extremely valuable for clinical applications.

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Nanoengineering Core The NanoEngineering Core develops and provides silicon-based nanotechnology to support innovative biomedical research. By taking advantage of industrial silicon microfabrication techniques, the core creates novel nanomaterials and nanodevices for biomedical applications. Through a combination of microfabrication and chemistry, the core personnel have developed a series of fabrication protocols to make various porous silicon particles for multistage delivery systems.

Important parameters of the multistage vectors: Varieties of microfabricated porous silicon vectors, surface properties, and porous structures.

Silicon Microfabrication Silicon microfabrication, a typical semiconductor industry process, is well established in terms of production and characterization. Scalability, precision and reproducibility are characteristics of the silicon microfabrication process. The Nanoengineering Core has developed a series of silicon-based nanomedicine platforms through the integration of industry silicon micromachining process and laboratory chemistry.

Our Specialized Services • D  evelop and produce silicon-based nanoparticles

- R  outine: 1 µm x 400 nm discs with 30 nm or 60 nm pores, 2.5 µm x 700 nm discs with 60 nm pores, and 600 nm x 400 nm discs with 30 nm pores.

- A  vailable by request: 7 µm x 2 µm discs, 3.2 µm hemisphere, 1 µm x 200 nm discs, 600 nm x 200 nm discs, 1 µm x 400 nm discs with larger pores, and 2.5 µm x 700 nm discs with larger pores

Porous Silicon Particles Porous Silicon Particles (PSPs) are fabricated by a combination of microfabrication process with electrochemical porosification. Owing to full biodegradability and readily modified surface properties, PSPs are emerging as promising injectable drug delivery carriers. The core designs and fabricates PSPs featuring precisely tailored size, shape, and porous structure. Based on the PSPs, the core develops multistage delivery systems comprising of several nested nanocomponents or “stages”, each of which is designed to negotiate one or more biological barriers. Stage 1 PSPs are rationally designed in a non-spherical geometry to enable superior blood margination and cell surface adhesion. Extended pore size range of PSPs is essential for the multistage system, enabling loading and transportation of a wide range of Stage 2 nanoparticles as well as bio-agents.

• D  esign and fabricate PSPs featuring precisely tailored size, shape, and porous structure • D  evelop multistage delivery system comprising several nested nanocomponents, each designed to negotiate one or more biological barriers • Fabricate stage 1 PSPs in a non-spherical geometry to enable superior blood margination and cell surface adhesion • D  esign and fabricate 3 dimensional nanostructures for biomedical application

Nanoengineering Core  
Nanoengineering Core