B2B Nutramedic&Cosmetics No. 13

The Future of Personalized Nutrition / Consumer Supplement Survey: Focus on Women / Key Nutrients in Managing Insulin Resistance / The Endocannabinoid System / Expert Insights / Infertility: Latest Evidence on Carob

Editor's word

This issue is packed with groundbreaking developments, expert analyses, and emerging trends that will undoubtedly influence the market landscape in the coming year. We are taking a detailed look at personalized nutrition, with a spotlight on microbiome testing, and innovations in the European supplement market, including Fine Foods’ advancements in capsule technology.

No.13 brings the 2024 ITC Insights Consumer Supplement Survey, focusing on women in the EU and UK, offering key data on consumer preferences and priorities. Zeus Hygia Lifesciences introduces Gremin®, a green coffee and curcumin­based performance enhancer poised to redefine sports nutrition. This edition also examines insulin management, and male fertility solutions with Carob, and Gelita’s innovative Omega-3 soft gels. Stay updated on EU regulations for retinol in cosmetics, and join us as we review highlights from Supply Side West.

Miguel Jiménez Del Río, CEO of Nektium, shares his expert insights into the botanical extracts and nutraceuticals industry. We hope this edition inspires you as you navigate the evolving landscape of health, nutrition, and cosmetics.

Warm regards,

Daria Šurić, MPharm, univ.spec.pharm.

EDITOR-IN-CHIEF

B2B Nutramedic&Cosmetics Magazine

4

The Future of Personalized Nutrition: Microbiome Testing 7

ACG Accelerates EU Growth with Major Expansion in Croatia

8

FOCUS ON WOMEN IN THE EU AND UK: Consumer Supplement Survey 14

Gremin®: Unleashing your Performance Potential

16

The Role of Insulin and Key Nutrients in Managing Insulin Resistance

Bimonthly digital magazine for industry professionals in health, nutrition and cosmetics sector

Bimonthly digital magazine for industry professionals in health, nutrition and cosmetics sector

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Ingredients and raw materials / Contract manufacturing Equipment & Packaging / Services / Industry events

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19 Putting Taste in the Limelight with GalenIQ 20 The Endocannabinoid System and Potential Therapeutic Ingredients

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The publisher does not assume responsibility for the opinions and data that the authors present in the magazine, as well as for the data and materials provided by companies for publication in texts and advertisements. It is not allowed to reuse any part of the content without the prior consent of the publisher.

The publisher does not assume responsibility for the opinions and data that the authors present in the magazine, as well as for the data and materials provided by companies for publication in texts and advertisements. It is not allowed to reuse any part of the content without the prior consent of the publisher.

Research: Health Claims Strongly Influence Younger Consumers 26

Impact of Lutein and Natural Zeaxanthin on Maternal and Infant Health

The Future of Personalized Nutrition: Trends Shaping 2025 - Microbiome Testing

Personalized nutrition, driven by advancements in microbiome testing, is transforming healthcare by offering tailored dietary recommendations based on an individual's gut microbiota, genetics, and lifestyle. By 2025, enhanced testing methods and integration with molecular biotechnology will enable more precise dietary interventions, but challenges like privacy concerns and access disparities must be addressed.

AUTHOR:

Ira Renko, MSc, Master in Molecular biotechnology

Introduction

Personalized nutrition has taken centre stage in modern healthcare, offering a tailored approach to dietary recommendations based on an individual’s unique biological, genetic, and lifestyle factors. Among these, the gut microbiome is proving to be a game changer. The human microbiome - a collection of trillions of microorganisms living in the digestive tract - plays an essential role in metabolism, immune function, and disease progression1,2. Through its interaction with endocrine, humoral, immunological, metabolic, and neural pathways, it influences overall health3,4

As we move towards 2025, the evolution of microbiome testing is rapidly increasing, dramatically influencing the field of personalised nutrition. The application of gut microbiome modulators has become more and more represented. Moreover, new methods for treating serious gastrointestinal conditions have been implemented. The integration of nutrition, pharmacology, and molecular biotechnology is set to launch a new era of personalised dietary interventions, potentially transforming healthcare.

What we know about gut microbiome

Microbiome testing has gained significant attraction in the last decade, with growing evidence linking the composition of gut bacteria to various health conditions, such as obesity, diabetes, inflammatory bowel disease, and even mental health disorders2,5-7 Currently, most microbiome tests use next-generation sequencing (NGS) technologies, which identify microbial DNA from stool samples. These tests analyse the relative abundance of bacterial species and provide insights into the balance of beneficial versus harmful bacteria8. What we know is that gut microbiome typically consists of 6 phyla Actinomycetota (past Actinobateria), Pseudomonadota (pastProteobacteria), Fusobacteriota (past Fusobateria), and Verrucomicrobiota (past Verrucomicrobia), Bacillota (past Firmicutes) and Bacteroidota (past Bacteroidetes)9. However, it is challenging to establish a definitive definition of a “normal” microbiota. Understanding the factors that shape gut microbiome composition is essential for developing strategies to support a healthy, diverse microbiota, which plays a key role in overall well-being and protection

Name of the metabolite

Tryptophan derivatives

Phenolic compounds

Hydrogen sulfide

Methane

Secondary amines

Short-chain fatty acids

Bacteria

Lactobacillus, Bacteroides, Escherichia coli, Clostridium

Clostridium difficile, Bacteroides

Desulfovibrio, Bilophila wadsworthia

Methanobrevibacter smithii

Clostridium, Bacteroides, Escherichia coli

Lactobacillaceae, Ruminococcaceae and Lachnospiraceae

against various health conditions10,11. Although early life stages and the host's genetic traits strongly impact the gut microbiota, it remains adaptable and can be shaped by various environmental factors, particularly diet12,13. Depending on the type and quantity of food that is consumed, gut microbiome composition changes. Dietary components directly affect the abundance of various microbial species in the gut, which in turn produce essential metabolites and signals that regulate the host's overall health. For example, a plant-based diet increases the abundance of Lactobacillus and Bifidobacterium, while a carnivore diet increases Bacteroides level14,15. What is more, metabolites produced by one species are used as a substrate for others and some are used by the human organism. Some of them can’t even be synthesised by the human body itself. Table 1. presents the main secondary metabolites that are produced by the gut microbiome. As it is clear from Table 1., some of the gut bacteria produce essential metabolites, while the others are unwanted, for example, methane16-18

Regarding the bacterial enterotypes, recent studies suggest that enterotypes may be useful for predicting dietary responses. The Prevotella-to-Bacteroides ratio has been closely linked to changes in body fat, weight, BMI, total cholesterol, and hormonal responses following dietary interventions19

Moreover, a capsaicin intervention study demonstrated that butyrate levels were significantly higher in individuals with a Bacteroides-dominated enterotype after capsaicin intake20. The increase in gastrointestinal hormones, such as GLP-1, GIP, and ghrelin, was associated with a greater abundance of Bacteroides21. Similarly, Hjorth et al. observed that individuals with high Prevotella levels experienced greater weight loss on the fiber­rich New Nordic Diet compared to a lower­fiber Danish diet, while those with low Prevotella showed no changes in

Type of intervention

Whole grain (150 g/day)

High protein and medium carbohydrate diet

Reduced fat, reduced carbohydrate diet

High fiber diet

Controlled basal diet

body weight19. However, gut microbiome modulation showed even more significant results in diseases such as irritable bowel syndrome, neuropsychiatric disorders, irritable bowel syndrome etc. 5-7, 22. A study by Zhang et al. showed that the efficacy of nutritional treatment for epilepsy depends on the gut microbiota23. Other study indicates that patients with IBS have different responsiveness depending on the baseline status of specific gut microbiota after consuming a low-FODMAP diet24

Future direction

Based on the evidence that gut microbiota can be rapidly changed with nutrition intervention, new food trends appear. For example, the change from an omnivorous diet to a vegetarian diet shows substantial changes in the intestinal microbiota in 4 days, while the variation in the consumption of the type of fats or dietary fiber is reflected in 14 days. Regarding dietary patterns, some of the new highly represented trends include keto diet, carnivore and vegan diet. Table 2. presents studies with different dietary interventions and their results25-29

As it is evident, from Table 2., shifts in nutrition lead to changes in composition, sometimes even an abundance of pathogenic bacteria. That is in correlation with data shown in Table 1. where specific bacteria metabolise certain substrates and produce metabolites that are either useful or harmful to the human body. Taking that into account, dietary interventions could be used for treating several diseases by modulating the gut microbiome.

By 2025, the costs of microbiome testing will likely decrease due to advancements in sequencing technologies. Also, the shift from 16S rRNA gene sequencing to full metagenomic sequencing will allow for more comprehensive analyses, not just of bacterial species but also viruses, fungi, and other micro-

Outcome

Increase in Clostridium leptum bacteria

Reduction of butyrate producing bacterias

Increase in Bacteroidetes and reduction in Firmicutes bacteria

Decrease pH, increase production of SCFA

Changes in the pH, production of short chain fatty acids, bacterial activity

TABLE 1 Secondary metabolites

TABLE 2 Dietary interventions

organisms that inhabit the gut. This will provide a holistic view of the gut ecosystem and lead to more precise recommendations for personalized nutrition30. Understanding the interplay between a person’s genetic makeup and their gut microbiome will allow for a more refined approach to nutrition. Personalized nutrition plans will be customized not only based on the microbiome but also on a person’s genetic predisposition to conditions like lactose intolerance, gluten sensitivity, or cardiovascular disease31. Probiotic and prebiotic supplements are already a significant part of the personalized nutrition landscape, but the future will bring more targeted approaches. For example, if a person has low levels of Bifidobacterium or Lactobacillus species, specific strains of probiotics may be recommended to restore balance32. Additionally, new types of prebiotics will be designed to selectively enhance the growth of certain microbes. As more research unveils how different fibers and compounds affect microbiota, customized prebiotics will become an integral part of personalized nutrition regimens, promoting specific health outcomes like enhanced metabolism or improved mental health33

Challenges and ethical considerations

As microbiome testing becomes a cornerstone of personalized nutrition, several ethical and practical challenges will emerge. Privacy concerns regarding microbiome data will be paramount, as such data could potentially be used by insurance companies or employers. Additionally, while personalized nutrition promises improved health outcomes, there is a risk of widening health disparities. Access to microbiome testing and related services may be limited to those who can afford them, potentially exacerbating health inequalities34

Despite its promise, the field still faces challenges. Standardization is one major issue; results can vary depending on the testing method or platform used. Furthermore, the interpretation of microbiome data remains a complex task, with many unknowns about what constitutes a "healthy" microbiome35. However, advancements in molecular biotechnology, combined with better clinical validation, are expected to resolve many of these limitations.

Furthermore, the science behind microbiome testing and its application in personalized nutrition is still evolving. While molecular biotechnologists and clinicians are uncovering exciting connections between the microbiome and health, the field is still in its infancy in terms of clinical applicability. It is essential that healthcare professionals, including pharmacists and dietitians, approach microbiome-based recommendations cautiously, ensuring they are supported by strong scientific evidence.

Conclusion

The future of personalized nutrition by 2025 is deeply intertwined with advancements in microbiome testing. As technologies evolve, the integration of microbiome data with genetic, pharmacological, and dietary information will enable healthcare providers to offer highly individualized nutritional advice. Molecular biotechnologists, pharmacists, and nutritionists will play pivotal roles in translating mi-

crobiome research into practical, personalized solutions that improve patient outcomes. Although challenges remain, the trends shaping microbiome testing hold immense potential to revolutionize how we approach diet, health, and disease prevention.

References:

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9 Syromyatnikov, M.; Nesterova, E.; Gladkikh, M.; Smirnova, Y.; Gryaznova, M.; Popov, V. Characteristics of the Gut Bacterial Composition in People of Different Nationalities and Religions. Microorganisms 2022, 10, 1866. https://doi.org/10.3390/ microorganisms10091866

10 Hasan N, Yang H. Factors affecting the composition of the gut microbiota, and its modulation. PeerJ. 2019 Aug 16;7:e7502. doi: 10.7717/peerj.7502

11 Wen L, Duffy A. Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes. J Nutr. 2017 Jul;147(7):1468S-1475S. doi: 10.3945/jn.116.240754

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13 Zhang P. Influence of Foods and Nutrition on the Gut Microbiome and Implications for Intestinal Health. Int J Mol Sci. 2022 Aug 2

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15 Lee C, Lee J, Eor JY, Kwak MJ, Huh CS, Kim Y. Effect of Consumption of Animal Products on the Gut Microbiome Composition and Gut Health. Food Sci Anim Resour. 2023 Sep;43(5):723-750. doi: 10.5851/kosfa.2023.e44.

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17 Swer NM, Venkidesh BS, Murali TS, Mumbrekar KD. Gut microbiota-derived metabolites and their importance in neurological disorders. Mol Biol Rep. 2023 Feb;50(2):1663-1675. doi: 10.1007/s11033-022-08038-0

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19 Hjorth MF, Blædel T, Bendtsen LQ, Lorenzen JK, Holm JB, Kiilerich P, Roager HM, Kristiansen K, Larsen LH, Astrup A. Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis. Int J Obes (Lond). 2019 Jan;43(1):149-157. doi: 10.1038/s41366-018-0093-2.

20 Rosca AE, Iesanu MI, Zahiu CDM, Voiculescu SE, Paslaru AC, Zagrean AM. Capsaicin and Gut Microbiota in Health and Disease.

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21 Hamamah S, Hajnal A, Covasa M. Influence of Bariatric Surgery on Gut Microbiota Composition and Its Implication on Brain and Peripheral Targets. Nutrients. 2024 Apr 5;16(7):1071. doi: 10.3390/ nu16071071

22 Stanghellini V, Barbara G. Gut microbiota signatures and modulation in irritable bowel syndrome. Microbiome Res Rep. 2022 Mar 5;1(2):11. doi: 10.20517/mrr.2021.12

23 Song EJ, Shin JH. Personalized Diets based on the Gut Microbiome as a Target for Health Maintenance: from Current Evidence to Future Possibilities. J Microbiol Biotechnol. 2022 Dec 28;32(12):14971505. doi: 10.4014/jmb.2209.09050.

24 Vervier K, Moss S, Kumar N, Adoum A, Barne M, Browne H, Kaser A, Kiely CJ, Neville BA, Powell N, Raine T, Stares MD, Zhu A, De La Revilla Negro J, Lawley TD, Parkes M. Two microbiota subtypes identified in irritable bowel syndrome with distinct responses to the low FODMAP diet. Gut. 2022 Sep;71(9):1821-1830. doi: 10.1136/gutjnl-2021-325177.

25 Hooda, S., Boler, B. M., Serao, M. C., Brulc, J. M., Staeger, M. A., Boileau, T. W., et al. (2012). 454 pyrosequencing reveals a shift in fecal microbiota of healthy adult men consuming polydextrose or soluble corn fiber. J. Nutr. 142, 1259–1265. doi:10.3945/jn.112.158766

26 Duncan, S. H., Belenguer, A., Holtrop, G., Johnstone, A. M., Flint, H. J., and Lobley, G. E. (2007). Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces. Appl. Environ. Microbiol. 73, 1073–1078. doi:10.1128/AEM.02340-06

27 Lai, M., Chandrasekera, P. C., and Barnard, N. D. (2014). You are what you eat, or are you? The challenges of translating high-fat-fed rodents to human obesity and diabetes. Nutr. Diabetes 4, e135. doi:10.1038/nutd.2014.30

28 Healey, G., Murphy, R., Butts, C., Brough, L., Whelan, K., and Coad, J. (2018). Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: A randomised, double-blind, placebo-controlled, cross-over, human intervention study. Br. J. Nutr. 119, 176–189. doi:10.1017/S0007114517003440

29 Johnson, S. K., Chua, V., Hall, R. S., and Baxter, A. L. (2006). Lupin kernel fibre foods improve bowel function and beneficially modify some putative faecal risk factors for colon cancer in men. Br. J. Nutr. 95, 372–378. doi:10.1079/bjn20051648

30 Wensel CR, Pluznick JL, Salzberg SL, Sears CL. Next-generation sequencing: insights to advance clinical investigations of the microbiome. J Clin Invest. 2022 Apr 1;132(7):e154944. doi: 10.1172/ JCI154944.

31 Adams SH, Anthony JC, Carvajal R, Chae L, Khoo CSH, Latulippe ME, Matusheski NV, McClung HL, Rozga M, Schmid CH, Wopereis S, Yan W. Perspective: Guiding Principles for the Implementation of Personalized Nutrition Approaches That Benefit Health and Function. Adv Nutr. 2020 Jan 1;11(1):25-34. doi: 10.1093/advances/nmz086.

32 Ji J, Jin W, Liu SJ, Jiao Z, Li X. Probiotics, prebiotics, and postbiotics in health and disease. MedComm (2020). 2023 Nov 4;4(6):e420. doi: 10.1002/mco2.420.

33 Lagoumintzis G, Patrinos GP. Triangulating nutrigenomics, metabolomics and microbiomics toward personalized nutrition and healthy living. Hum Genomics. 2023 Dec 8;17(1):109. doi: 10.1186/ s40246-023-00561-w.

34 Pedroza Matute S, Iyavoo S. Exploring the gut microbiota: lifestyle choices, disease associations, and personal genomics. Front Nutr. 2023 Oct 5;10:1225120. doi: 10.3389/fnut.2023.1225120

35 Allaband C, McDonald D, Vázquez­Baeza Y, Minich JJ, Tripathi A, Brenner DA, Loomba R, Smarr L, Sandborn WJ, Schnabl B, Dorrestein P, Zarrinpar A, Knight R. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. Clin Gastroenterol Hepatol. 2019 Jan;17(2):218-230. doi: 10.1016/j. cgh.2018.09.017

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ACG Accelerates European Growth with Major Expansion in Croatia

Expanded production facilities and new warehouses will boost efficiency, reduce lead times and enhance regional supply chains.

ACG, the world’s leading integrated provider of oral dosage solutions, is set to expand its footprint in Europe with significant upgrades to its Croatian operations. The expansion includes increased production capacity at ACG Capsules’ Croatian facility and the opening of new warehousing and slitting facilities by ACG Packaging Materials division.

This strategic move strengthens ACG’s presence in Europe, enhancing its ability to meet growing customer demand while streamlining supply chains across the region. Since acquiring Croatia’s Lukaps capsule shell manufacturing plant in 2007, ACG has invested over 50 million euros in infrastructure, technology, and process upgrades, bringing the site to world-class standards. The latest phase of the expansion will be completed by the end of 2024, and production capacity has already surged by more than 80% in the past year alone.

Selwyn Noronha, CEO at ACG Capsules, said: "The expansion of our Croatian facility marks a pivotal moment in our European strategy. By boosting production and logistics capabilities, we are not only improving lead times but also contributing to the local economy by creating new job opportunities. This facility meets the highest global manufacturing standards, and we are replicating our sustainability initiatives here, ensuring our operations benefit both the environment and the communities we serve."

SR Shivshankar, CEO at ACG Packaging Materials, added: "The opening of our new warehouse in Croatia is a crucial step in increasing our agility and better serving our European customers. With shorter lead times and enhanced flexibility, this warehouse will allow us to respond to market demands faster and more efficiently. We are excited for the facility to be fully operational by November 2024."

ACH has showcased its offerings at CPHI Worldwide in Milan.

FOCUS ON WOMEN IN THE EU AND UK Highlights From The ITC Insights 2024 Consumer Supplement Survey

The 2024 ITC Insights Consumer Supplement Survey „Focus on Women in the EU and UK“ was fielded from February to March 2024 and analyzed by the Industry Transparency Center.

AUTHOR: Len Monheit, CEO, Industry Transparency Center

Industry Transparency Center (ITC) is a data, strategy and insights company focused on the health ingredients and natural product sectors globally. With a deep background in strategy, sourcing and supply chain the team at ITC works with industry, consumers and influencers to understand values, behaviors, purchase drivers to understand and predict trends and guide its education programs for maximum impact. The team produces virtual conferences highlighting emerging and validated nutrition

science, driving its application in industry settings.

The survey includes over 4000 supplement consumers ages 18+ in 6 countries: US (1000), UK (500), DE (500) IT: (500), KR: (500), AU: (500), IN: (500). This extract views female users from the UK, Germany and Italy. The survey provides insights into supplement user buying behaviors and priorities, including familiarity, usage patterns, purchase drivers, branded ingredients and the importance of values like trust, transparency and sustainability.

HEALTH CONCERNS: SUPPLEMENT USE AND WILLINGNESS TO USE

Key Insight:

We see more of a willingness to treat than currently treating with supplements across the board, but we see that there is high willingness, almost matching the level of concern for issues such as immunity, osteoporosis and even cardiovascular issues in the middle. Some of the largest gaps are for mental health-related concerns such as lack of mental acuity/focus.

Question:

“Would you consider supplements for any of the following health concerns?” The results shown are a percentage relative to the reporting rate. (Figure 1.)

HEALTH CONCERNS: TOP 10

Key Insights:

Top reported health concerns among European females are mostly mental health related. Here we can more clearly see the gap between those currently addressing with supplements and those willing to treat with supplements among the top 10 health concerns. Measuring the 'white space' by itself literally drives attention to both lack of energy and joint or other pain while also showing significant opportunities in pretty much all the other 'Top 10'.

Question:

“Would you consider supplements for any of the following health concerns?” (Figure 2.)

FIGURE 1 EU Female n=796

FIGURE 2 UK Female n=256, DE Female n=266, IT Female n=274

FAMILIARITY WITH INGREDIENTS

Key Insight:

Overall familiarity levels with most ingredients are relatively high among Italian females, particularly for many of the lesser-known supplements such as melatonin, biotin and vitamin K2.

IMPORTANT ATTRIBUTES WHEN BUYING

Key Insight:

Each respondent group sees a different top response. For the UK, it addresses specific concerns, for Germany it is a natural source, and for Italy, it is a health care professional recommendation.

Question:

“How familiar would you consider yourself regarding the use of these supplements?” The sum of all responses except for “Never heard of it”. (Figure 3.)

Question:

“What are the most important attributes you look for when purchasing supplements?” (Figure 4.)

FIGURE 4 UK Female n=256, DE Female n=266, IT Female n=274

FIGURE 3 UK Female n=256, DE Female n=266, IT Female n=274

IMPORTANT ATTRIBUTES 2023-2024

Key Insights:

Consumers are looking more for supplements from a natural source from brands with more clinical research and that they have experience with in 2024 compared to 2023.

PREFERRED SUPPLEMENT FORMAT

Key Insights:

Tablet is far and away the number one response from each group, showing a slight older skew. The gummy format sees the highest responses from females in the UK with a younger skew.

Question:

“What are the most important attributes you look for when purchasing supplements?” (Figure 5.)

Question:

“In which format do you prefer your supplements? (Figure 6.,7.)

FIGURE 5 2023 EU Female n=775, 2024 EU Female n=796

FIGURE 6 UK Female n=256, DE Female n=266, IT Female n=274

FIGURE 7 EU Female 18-34 n=265, EU Female 35-54 n=321, EU Female 55+ n=210

FORMAT CHARACTERISTICS

Key Insight: A supplement that is a single daily dose and easy to swallow is the main characteristic females are looking for.

Question: “What do you like about these formats?” (Figure 8.,9.)

FIGURE 8 UK Female n=256, DE Female n=266, IT Female n=274

FIGURE 9 EU Female 18-34 n=265, EU Female 35-54 n=321, EU Female

TRANSPARENCY SIGNALS

Key Insights:

Over one third of these consumers are greatly influenced by transparency. Very few results come in for not believing any brands are operating transparently. Quality seals and ingredient information are the most important transparency builders.

Question:

“Which of the following items are the strongest signals that a supplement brand is operating transparently?” (Figure 10.)

Question:

“How likely are you to purchase supplements from a manufacturer that provides transparency information on its label or website?” (Figure 11.)

Source: The 2024 ITC Insights Consumer Supplement Survey

https://itcstrategy.com/

len@itcstrategy.com info@itcstrategy.com

FIGURE 10 UK Female n=256, DE Female n=266, IT Female n=274

FIGURE 11 EU Female n=796

Gremin®: Unleashing your Performance Potential

Gremin® is a revolutionary force in performance enhancement, developed by Zeus Hygia Lifesciences, India, which combines Green coffee bean extract and Curcumin into a bioactive, water-dispersible powder. Backed by scientific validation, including two human clinical studies, Gremin® is proven to expedite recovery, bolster endurance, and aid lean mass, positioning it at the forefront of sports nutrition. With versatile applications like powders, RTD mixes, bars, and capsules, Gremin® offers an innovative, science-driven solution to unlock athletic potential and muscle recovery.

Gremin® isn't just another sport and active nutrition; it's a revolutionary force in performance enhancement. Gremin® developed by Zeus Hygia Lifesciences, India ingeniously combines dual bioactives (Green coffee bean extract with Curcumin) into a single food-grade carrier enriching its properties. This pioneering approach yields a water-dispersible powder, standardized for Chlorogen-

ic acid and Curcuminoids at an optimal ratio with good sensory feel & stability. Unlike other options, Gremin® boasts unparalleled efficacy, meticulously crafted to deliver superior results.

Scientific background

Gremin®, a patented & Health Canada Licensed (NPN) ingredient, stands firmly on a foundation of

robust scientific validation (backed by 2 human clinical studies). The clinical studies at 500mg daily dose reveal its remarkable potential in:.

• Expediting recovery: Studies show Gremin® facilitates faster post-workout recovery, allowing athletes to bounce back quicker and train harder.

• Bolstering stamina & endurance: Gremin® empowers athletes to push further with increased stamina and endurance, helping achieve peak performance.

• Aiding lean mass: Research suggests Gremin® may play a role in increasing lean mass /fat-free mass management, offering a well­rounded approach to fitness.

• Regulating muscle pain: Gremin® demonstrably reduces muscle pain, and inflammation makes recovery a smoother process

• Manages fatigue: Gremin® stands out with its potential in managing fatigue, which boosts consistency and performance.

These findings solidify Gremin’s position at the forefront of sports & active nutrition segments, promoting exceptional performance support and overall muscle protection.

Gremin transcends the limitations of a mere product; it's a performance powerhouse aimed at revolutionizing sports nutrition. Strategically positioned within the wellness segment, Gremin® offers a comprehensive solution for enhanced fitness and athletic achievement:

• Sports nutrition – for daily work out/for moderate exercise groups

• Sports nutrition – for athletic performance/ sports recovery

• Active nutrition – energy/exercise support for beginners & ageing population

• Healthy aging – age-related muscle loss/fatigue/ energy boost

Dosage and application

The recommended daily dose of Gremin® is 500 mg. This convenient dosage can be easily incorpo-

rated into te daily routine. Gremin's versatility shines through its diverse application formats. It's available in a variety of options to suit consumer preferences, including:

• Powder: Ideal for mixing with Protein powder or other workout supplements.

• Ready-to-Drink (RTD) powder mixes: A convenient and delicious way to consume a daily dose of Gremin®.

• Bars: Enjoy a tasty and portable option packed with the performance­enhancing benefits of Gremin®

• Gummies: A fun and flavorful way to experience the power of Gremin®.

• Tablets and capsules: A simple and precise dosing approach to incorporating Gremin® into your routine.

Conclusion

Gremin® embodies innovation and efficacy in the realm of sports & active nutrition segments. Gremin® is the world's first and only branded ingredient combines Green coffee extract with Curcumin and backed by multiple clinical studies, setting a new standard for performance enhancement and muscle recovery. Whether incorporated into a product for a seasoned athlete striving for excellence or a passionate fitness enthusiast pushing your limits, Gremin® empowers consumers to unlock their full potential and achieve groundbreaking results. Experience the difference with Gremin® – where science fuels performance, and excellence becomes attainable.

Gremin, manufactured by Zeus Hygia Lifesciences India is distributed by a leading German distributor Josh Naturals GmbH in Germany and other European markets.

Meet us at Fi , Europe , Booth No 4.1F66, book meetings at info@zeushygia.com https://www.zeushygia.com/

For samples & technical details please contact:

Mr. Wesley Suresh wes@joshnaturals.com Phone +49 69153 46749 https://www.joshnaturals.com/

The Role of Insulin and Key Nutrients in Managing Insulin Resistance

Insulin, a protein made of 51 amino acids, regulates glucose and fat metabolism by promoting glucose storage and reducing fat breakdown. Insulin resistance occurs when tissues like muscles and the liver become less responsive to insulin, leading to glucose buildup in the blood. Factors influencing insulin resistance include poor diet, lack of physical activity, and deficiencies in key nutrients like magnesium, chromium, and vitamin D, which play crucial roles in maintaining insulin sensitivity.

AUTHOR: Ružica Dizdar, MPharm, univ.spec. pharm.

In 1921, Frederick Banting and Charles Best discovered insulin, a 51 amino-acid protein composed of two peptide chains, A and B1. Insulin influences metabolism of glucose, regulating plasma glucose levels and stimulating glucose storage in organs such as muscles, the liver and adipose tissue. It also influences fat metabolism, increasing the storage of triglycerides and decreasing lipolysis. Ketone body metabolism also depends on insulin action, as insulin reduces ketone body concentrations and influences protein metabolism. It increases nitrogen retention and increases the synthesis of proteins. Insulin is also involved in cellular growth and proliferation2

Insulin restistance

Insulin resistance is generally defined as reduced ability of insulin to activate insulin signaling pathways, resulting in increased fasting serum glucose and other abnormalities in glucose and fat metabolism. It is the underlying cause of type 2 diabetes and is also associated with non-alcoholic fatty liver disease3. It is closely related to metabolic syndrome and has been associated with high-calorie food consumption,

limited physical activity and excessive stress. Insulin resistance is a clinical condition in which tissues sensitive to insulin, mostly skeletal and cardiac muscle, adipose tissue and the liver, have a diminished ability of glucose uptake due to a reduced biological effect of insulin in comparison with healthy individuals. The excess glucose in the bloodstream leads to hyperglycemia and indirectly to hyperinsulinemia with subsequent disruption of glucose metabolism. It has been extensively linked with chronic lowgrade inflammation and production of proinflammatory cytokines, such as tumor necrosis factor α (TNF-α), interleukin (IL)-6, IL-8, plasminogen activator inhibitor-1 (PAI-1) and monocyte chemoattractant protein-1 (MCP-1). Their increased production is accompanied by elevated levels of C-reactive protein (CRP), a widely used inflammatory biomarker. Insulin resistance alone has been named as a separate risk factor for cardiovascular events, even in patients without diabetes mellitus1. Genetic and environmental factors contribute to the development of insulin resistance, specifically in mutations in genes that are associated with intracellular insulin signaling pathways2

Insulin restistance related diseases in human

Insulin resistance can be connected with many diseases and conditions which include obesity, diabetes, nonalcoholic fatty liver disease, cardiovascular diseases, polycystic ovary syndrome, and other abnormalities.

Insulin resistance can occur in patients with a history of diabetes in first­degree relatives, patients with a personal history of gestational diabetes, polycystic ovary syndrome or impaired glucose tolerance and obese patients, particularly those with abdominal obesity8.

Non-alcoholic fatty liver disease

Non­alcoholic fatty liver disease is defined as excess accumulation of fat (triglycerides) in hepatocytes that is not connected with alcohol consumption. It is the hepatic manifestation of the metabolic syndrome and it can be associated with insulin resistance. Approximately one in four adults in the Western world has this disease and the prevalence is increasing in Asia. An estimated 20% of patients with non-alchocolic fatty liver disease have steatohepatitis, a type of liver injury characterized by accumulation of fat, inflammation, and fibrosis, that can progress to cirrhosis and liver failure3

Diabetes mellitus

According to the 10th edition of the IDF Diabetes Atlas, 536.6 million people worldwide have diabetes, which means that more than 10.5% of the world’s adult population has the disease. It is predicted to rise to 12.2% (783.2 million people) by 2045. Since insulin is crucial hormone that regulates blood sugar, insulin resistance is also associated with all stages of diabetes mellitus, including prediabetes, diabetes,

and its complications. Impaired β-cell compensation in response to increased insulin resistance is a pathophysiological factor associated with poor glucose tolerance, which contributes to the development of diabetes mellitus5.

Polycystic ovary syndrome (PCOS)

Polycystic ovary syndrome (PCOS) is a disorder with both endocrine dysfunction and metabolic dysfunction which impacts almost 20% of female patients of reproductive age6. Around 70%–80% of women with PCOS and central obesity and 15%–30% of lean women with PCOS have insulin resistance and compensatory hyperinsulinaemia10. The symptoms of PCOS include androgen excess (hirsutism and/or hyperandrogenemia) and ovarian dysfunction (oligo-ovulation and/or polycystic ovarian morphology). As an increasing number of studies focus on the phenotype and underlying mechanisms of PCOS, it is suggested that insulin resistance and hyperinsulinism are responsible for the excessive androgen secretion in PCOS beacuse insulin can react on the ovary as a cogonadotropin and trigger androgen secretion from the adrenal glands. This could mean that insulin resistance and hyperinsulinism are the pathophysiological factors in the development of PCOS6

Cardiovascular diseases

During the initial phase of atherosclerosis, endothelial injury triggers the production of proinflammatory cytokines like MCP-1, ILs, TNF-α and adhesion molecules. This can lead to increased production of CRP and these same events occur in insulin resistance. Impaired insulin cellular signaling in insulin reistance alters glucose metabolism and endothelial dysfunction and may contribute to the acceleration

PICTURE 1 Insulin resistance related diseases in human

Taken from: LiM,ChiX,WangY,SetrerrahmaneS,XieW,XuH.Trendsininsulinresistance:insightsintomechanismsandtherapeutic strategy.SignalTransductTargetTher.2022Jul6;7(1):2164

Hypetinsulinema

Impaired

of atherosclerosis. Numerous studies link insulin resistance with other cardiovascular conditions including obesity, hypertension and heart failure1

Insulin resistance management

Lifestyle changes

Lifestyle factors including diet, exercise, smoking, sleeping and stress are considered to contribute to insulin resistance. Irregular daily eating habits or poor sleep are connected to higher risk for both obesity and insulin resistance. Epidemiologic studies showed that individuals with regular exercise, healthy diet who limited their daily alcohol intake, avoided smoking cigarettes and reduced levels of stress increased their insulin sensitivity4. Exercise is known to improve metabolic diseases by improving obesity and increasing insulin sensitivity. A meta­analysis showed the effectiveness of a structured exercise intervention program for insuline resistance in type 2 diabetes mellitus. The evidence suggests that regular exercise improves glycemic control and can be recommended for reducing insulin resistance with a moderate level of evidence.

Weight loss and dietary changes such as intermittent fasting programs that reduce carbohydrates in the diet can significantly improve glycemic and insulin responses. From the available studies, reducing total daily carbohydrate intake to 40-50% of daily energy intake, such as a Mediterranean-style diet and high protein diet, is one of the key dietary habits for improving insulin resistance.

Also, a key dietary strategy for treating insulin resistance and improving glycemic control is to consume foods and meals that reduce the glucose fluctuations known to induce oxidative stress and beta cell damage. Studies suggest that calorie restriction for weight loss and macronutrient composition of the diet are also very important. In recent years some researchers have suggested that consumption of carbohydrates rich in dietary fiber and with low glycemic index, such as whole grains, could be beneficial in improving insulin sensitivity and meta-

bolic flexibility. One meta­analysis reported that increasing daily fiber intake by 15 or 35 grams compared to a low­fiber diet reduced homeostatic model assessment of insulin resistance (HOMA-IR), leading to improvements in glycemic control, lipids, weight, and inflammation, as well as a reduction in premature mortality5

Vitamin D

Many studies suggest that vitamin D supplementation might reduce insulin resistance in some people due to increasing insulin receptor genes transcription and anti­inflammatory properties, while some researchers found that vitamin D has no effect on insulin resistance. Because of that, more studies should be performed to learn more about the mechanism and the effect of vitamin D on insulin resistance4. Vitamin D can be a promising but unproven adjuvant therapy intervention for type 2 diabetes mellitus and for reducing risk of diabetes in general through regulating insulin resistance7

Minerals

Minerals are essential micronutrients for the human body. Deficiencies in certain micronutrients because of the differences in our diet may lead to imbalances in glucose homeostasis and insulin resistance.

Magnesium is a cofactor required for glucose access to cells and carbohydrate metabolism, and it has the function of regulating the electrical activity of pancreatic beta cells and insulin secretion. Low magnesium ion levels can lead to defective tyrosine kinase activity, blocking intracellular insulin action. Magnesium deficiency inhibits cellular defenses against oxidative damage and triggers chronic systemic inflammation that enhances insulin resistance. However, new studies are needed to clarify the role of nutrients in the prevention of this metabolic disorder, as well as to standardize the type, dose, and timing of magnesium supplementation. Also, changes in zinc homeostasis have been associated with diabetes and insuline resistance5.

PICTURE 2 Role of insulin resistance in the development of polycystic ovarian syndrome (PCOS)

Taken from: Kamenov Z, Gateva A. Inositols in PCOS. Molecules. 2020 Nov 27;25(23):556612

Chromium is also suggested as potetntial micronutrient that can help with insulin resistance. Most diets cannot fulfill the suggested intake of 50 mg for chromium and inadequate chromium levels can lead to signs and symptoms similar to those of diabetes and cardiovascular diseases. Chromium can improve insulin binding, receptor number and insulin receptor enzymes by increasing insulin sensitivity, β cell sensitivity and insulin internalization9

Myo-inositol

Myo-inositol, also known as inositol (cyclohexanehexol), is a cyclic carbohydrate with six hydroxyl groups. It was considered a B vitamin (vitamin B8) but it is actually an essential nutrient because it is formed from glucose. Myo-inositol should be considered in patients with insulin resistance, metabolic syndrome, type 1 diabetes, type 2 diabetes, polycystic ovary syndrome and those with or at risk of gestational diabetes. Myo-inositol is also important for insulin signalling as it makes up many secondary messengers in response to insulin10,11.

Conclusion

Different interactions and distinct molecular, cellular and physiological mechanisms contribute to the relationship between insulin resistance and different metabolic dysfunctions. These interactions unfortunately still remain unknown to the fullest. Understanding of insulin signaling and insulin resistance will stimulate new therapy designs, including gene therapies and new drugs. Further invitroand in vivo studies are required, in order to attempt to clarify the complex mechanisms that lead to insulin resistance. Also, insulin resistance in children is an important field for researchers that could lead to new protocols that would reduce child and adult obesity as a long-term consequence.

References:

1 Kosmas CE, Bousvarou MD, Kostara CE, Papakonstantinou EJ, Salamou E, Guzman E. Insulin resistance and cardiovascular disease. J Int Med Res. 2023 Mar;51(3):3000605231164548.

2 Szablewski L. Changes in Cells Associated with Insulin Resistance. Int J Mol Sci. 2024 Feb 18;25(4):2397.

3 Kathirvel E, Morgan K, Malysheva OV, Caudill MA, Morgan TR. Betaine for the prevention and treatment of insulin resistance and fatty liver in a high-fat dietary model of insulin resistance in C57BL mice. Front Nutr. 2024 Jul 25;11:1409972.

4 Li M, Chi X, Wang Y, Setrerrahmane S, Xie W, Xu H. Trends in insulin resistance: insights into mechanisms and therapeutic strategy. Signal Transduct Target Ther. 2022 Jul 6;7(1):216.

5 Zhao X, An X, Yang C, Sun W, Ji H, Lian F. The crucial role and mechanism of insulin resistance in metabolic disease. Front Endocrinol (Lausanne). 2023 Mar 28;14:1149239.

6 Gu Y, Zhou G, Zhou F, Wu Q, Ma C, Zhang Y, Ding J, Hua K. Life Modifications and PCOS: Old Story But New Tales. Front Endocrinol (Lausanne). 2022 Apr 13;13:808898.

7 Lei X, Zhou Q, Wang Y, Fu S, Li Z, Chen Q. Serum and supplemental vitamin D levels and insulin resistance in T2DM populations: a meta-analysis and systematic review. Sci Rep. 2023 Jul 31;13(1):12343.

8 Goutham R. Insulin resistance syndrome. Am Fam Physician. 2001;63(6):1159-1164

9 Dubey P, Thakur V, Chattopadhyay M. Role of Minerals and Trace Elements in Diabetes and Insulin Resistance. Nutrients. 2020 Jun 23;12(6):1864.

10 DiNicolantonio JJ, H O'Keefe J. Myo-inositol for insulin resistance, metabolic syndrome, polycystic ovary syndrome and gestational diabetes. Open Heart. 2022 Mar;9(1):e001989.

11 Kamenov Z, Gateva A. Inositols in PCOS. Molecules. 2020 Nov 27;25(23):5566.

Putting Taste in the Limelight with GalenIQ

At the CPHI Milan trade show visitors had the opportunity to discover how Beneo’s agglomerated pharmaceutical excipient galenIQ™ can be incorporated into a variety of oral solid dosage (OSD) forms.

In both the nutraceutical and pharmaceutical markets, demand for palatable dosage forms such as sachets and medicated candies/gummies is on the rise.

“For these types of products,” observes Oliver Luhn, Head of Pharmaceutical Technology at Beneo, “palatability plays a significant role. Combining an appealing taste profile with excellent technical properties can make a huge difference. As a result, we’re seeing growing market interest in easy-to-process products such as our bulk sweetener galenIQ™.”

In addition, galenIQ™ is a versatile solution that can be used in a wide variety of applications. Michael Black, Head of Sales Pharma at Beneo, invites interested parties to the booth to learn more about products that have been formulated with the company’s filler­binder, such as chewable tablets, medicated compressed lozenges and high boiled lozenges, sachets and more.

“We’re keen to discuss how galenIQ™ can address sensory challenges in the development process, such as bitter notes associated with many active pharmaceutical ingredients or formulations containing herbal extracts, thus contributing to an improved flavour profile,” adds Black.

Formulating for a better patient experience

Derived from sugar beet, galenIQ™ has a sweetening profile that’s almost equal to sucrose (while being non-cariogenic). Beneo‘s excipient also scores when it comes to functional properties such as excellent flow/mixing properties and high compactability, all of which contribute to the stability of pharmaceutical OSDs. From a quality control perspective, galenIQ™ is manufactured according to GMP standards for pharmaceutical excipients and various grades are available to suit different dosage forms.

Maj-Britt Cepok, Head of Business Development Pharma at Beneo, commented: “On the one hand, dosage forms are getting more diverse. On the other hand, in line with a more consumer-centric approach, there’s a stronger focus on how to make taking medicines as comfortable and convenient as possible. An appealing flavour can have a significant influence on patient compliance and, with galenIQ™, manufacturers have access to a reliable solution that can help them to achieve a well­balanced sensory profile.”

The Endocannabinoid System and Potential Therapeutic Ingredients

The endocannabinoid system (ECS) includes cannabinoid receptors, endogenous ligands, and enzymes that maintain energy balance and cognitive function. This system is essential in managing pain, inflammation, mood, and memory, making it a promising target for new therapies. Phytocannabinoids, synthetic cannabinoids, and plant-derived compounds continue to show potential in treating neurological disorders and other conditions.

AUTHOR: Dari Šurić, MPharm, univ.spec.pharm.

Since the discovery of the endocannabinoid system (ECS) in the 1990s, this signalling system has attracted intense attention, especially as it aided understanding of the effects of phytocannabinoids. Furthermore, detailing the various components of the ECS uncovered the fascinating complexity of how this signalling system acts in the functional network of the entire organism, particulary in the brain.

The ECS has been studied to identify the molecular structures present in Cannabis sativa . The ECS consists of cannabinoid receptors, endogenous ligands, and the associated enzymatic apparatus responsible for maintaining energy homeostasis and cognitive processes. Several physiological effects of cannabinoids are exerted through interactions with various receptors, such as CB1 and CB2 receptors, vanilloid receptors, and the recently discovered G-protein-coupled receptors.

Anandamide (AEA) and 2-arachidoylglycerol (2AG), two small lipids derived from arachidonic acid, showed high­affinity binding to CB1 and CB2 receptors. ECS plays a critical role in chronic pain and mood disorders and has been extensively studied because of its wide therapeutic potential and because it is a promising target for the development of new drugs. Phytocannabinoids and synthetic cannabinoids have shown varied affinities for the ECS and are relevant to the treatment of several neurological diseases1

The ECS is a highly versatile signalling system within the nervous system. The endocannabinoid system is a complex network of receptors, enzymes, and endogenous lipid-based retrograde neurotransmitters that play a crucial role in regulating a wide range of physiological and pathological processes1,2,3. This system is involved in the modulation of pain and inflammation, as well as various other func-

Taken from: RezendeB,AlencarAKN,deBemGF,Fontes-DantasFL,MontesGC.EndocannabinoidSystem:ChemicalCharacteristics andBiologicalActivity.Pharmaceuticals(Basel).2023Jan19;16(2):148.doi:10.3390/ph16020148.PMID:37017445;PMCID:PMC9966761.

tions such as mood, appetite, and memory.

The two main cannabinoid receptors, CB1 and CB2, have been extensively studied and are known to mediate the effects of both endocannabinoids and phytocannabinoids, such as the psychoactive compound Δ9­tetrahydrocannabinol found in the cannabis plant. Activation of CB1 receptors, primarily located in the central nervous system, can produce analgesic, anti­inflammatory, and neuroprotective effects, while CB2 receptors, predominantly expressed in the peripheral immune system, are involved in modulating inflammatory and immune responses2,3,4.

In addition to the cannabinoid receptors, the ECS also includes the endogenous ligands, AEA and 2-AG, as well as the enzymes responsible for their synthesis and degradation2. These endocannabinoids have been shown to exhibit a range of therapeutic properties, including pain relief, anti­inflammatory, and neuroprotective effects. It appears that the ECS plays roles in the fine­tuning of physiological processes that keep the body in homeostatic setpoints.

The ECS is also widely involved in the regulation of peripheral immune, cardiovascular, metabolic, gastrointestinal, muscular, and peripheral nervous system processes, which in turn can influence central nervous system (CNS) functions. The ECS is evolutionarily well conserved in vertebrates, is widely distributed in the body, and takes a central position in the regulation of a myriad of biological processes, both in neural and non-neural tissues. It is intertwined with many neurotransmitter and lipid signal-

ling systems, thereby integrated into broad functional networks. It appears that the ECS plays roles in the fine­tuning of physiological processes that keep the body in homeostatic set-points.

ECS dysregulation can also be induced by particular life factors, such as living under chronic stress, or by metabolic factors, such as obesity. Pharmacological interventions targeting ECS activity aim to normalize such pathophysiological processes, thereby rescuing the subject from unfavourable allostatic set points.

Functions of the ECS helps to maintain homeostasis in the body, for example, through regulation of the stress response, feeding, and energy metabolism, and for ensuring the excitatory/inhibitory balance in the nervous system. Considering the temporal and spatial activity of the ECS, it is no surprise that a dysregulated ECS can lead to new set points, called allostasis, that might then be implicated in distinct neuropsychiatric disorders.

The biosynthesis of endocannabinoids occurs from membrane precursors, and the ECS degradation products are precursors of eicosanoids. Thus, ECS signalling is integrated into a lipid metabolism and signalling network1.

Exogenous, plant-based cannabinoids and related compounds, such as terpenes, have also been investigated for their potential therapeutic applications.

Studies have suggested that compounds like cannabidiol and β-caryophyllene, when used in combination, may provide effective pain relief and anti­inflammatory benefits without the psychoactive effects associated with Δ9­tetrahydrocannabinoids2,3,4

FIGURE 1 CB1 and CB2 cannabinoid receptors and their distribution in the human body

The endocannabinoid system and its modulation have been implicated in a wide range of pathological conditions, including chronic pain, inflammation, and neurological disorders. Ongoing research continues to explore the therapeutic potential of targeting the endocannabinoid system, with a focus on developing selective agonists and antagonists that can harness the beneficial effects while minimizing undesirable side effects1,2,4,5

Recently, the ECS has been expanded, and researchers have named it the endocannabinoidome (ECSome), a meaningful reference that includes all components as well as proteins, enzymes, and lipids that are directly or indirectly involved in cannabinoid system modulation and significantly affect health.

Natural products have a long history of interactions with CB receptors. Preparations of the medicinal plant Cannabis sativa have been therapeutically used for thousands of years before their mechanism of action – the activation of CB receptors – had been discovered and the active constituents like THC had been identified. In addition to cannabis constituents further plant-derived natural products have been reported to interact with the endocannabinoid system, including the terpene beta-caryophyllene, fatty acid derivatives, such as N-linoleoylethanolamide, and various N-alkylamides from Echinacea spp. These compounds may either act directly on CB receptors (beta-caryophyllene) or indirectly by inhibition of endocannabinoid degradation.

Phytocannabinoids, such as cannabidiol (CBD), have wide therapeutic applicability, possibly because of their ability to target numerous receptors. The ECSome plays a role in the microbiota–gut–brain axis, which has emerged as an important player in

the control of affective and cognitive functions and their pathological changes. However, the molecular and biochemical bases of the interaction and the biological relationships of the new receptor subtypes with cannabinoid ligands have not been fully elucidated; therefore, further studies are needed.

Endocannabinoids, unlike classical neurotransmitters, are considered atypical messengers because of the modulation of information from postsynaptic terminals to presynaptic terminals, which is known as the retrograde signalling mechanism. Endogenous ligands are synthesized on demand or by activity dependent on the cleavage of the phospholipid membrane and are released immediately after their biosynthesis to act as pro-homeostatic factors through interactions with specific receptors.

Molecules that modulate the endocannabinoid system

Cannabis, an herbal medicine, is a complex mixture of several compounds, including cannabinoid phenols, non-cannabinoid phenols (simple phenols, spiro-indans, dihydrophenanthrenes, and dihydrostilbenes), flavonoids, terpenoids, alcohols, aldehydes, n-alkanes, wax esters, steroids, and alkaloids.

However, in the past, studies were focused on the two most abundant phytocannabinoids, THC and CBD, thus resulting in greater knowledge about their pharmacological activities and increasing interest in the numerous possibilities of the medicinal actions of the plant. CBD has been gaining prominence in pharmacological research since the 1970s.

Since research with derivatives of Cannabis has started and the biological functions of isolated compounds in experimental and human diseases have shown promising outcomes, it is evident that selec-

Taken from: Burlou­Nagy,C.,Bănică,F.,Jurca,T.,Vicaș,L.G.,Marian,E.,Muresan,M.E.,Bácskay,I.,Kiss,R.,Fehér,P.,&Pallag,A.(2022). Echinaceapurpurea(L.)Moench:BiologicalandPharmacologicalProperties.AReview.Plants(Basel,Switzerland),11(9),1244. https://doi.org/10.3390/plants11091244

FIGURE 2 Properties of Echinaceapurpurea (L.) Moench.

tive ligands of specific Cannabis receptors could induce beneficial outcomes, depending on the clinical condition. More research on the biological function of each Cannabis derivative should be encouraged6

Palmitoylethanolamide (PEA)

N-Palmitoylethanolamide (PEA) is a non-endocannabinoid lipid mediator belonging to the class of the N­acylethanolamine phospholipids and was first isolated from soy lecithin, egg yolk, and peanut meal.

PEA, an endocannabinoid-like lipid mediator, has extensively documented anti­inflammatory, analgetic, antimicrobial, immunomodulatory and neuroprotective effects. It is well tolerated and devoid of side effects in animals and humans. PEA’s actions on multiple molecular targets while modulating multiple inflammatory mediators provide therapeutic benefits in many applications, including immunity, brain health, allergy, pain modulation, joint health, sleep and recovery. PEA’s poor oral bioavailability, a major obstacle in early research, has been overcome by advanced delivery systems now licensed as food supplements. Belongs to the N-acyl-ethanolamine (NAE) fatty acid amide family. It is synthesized on demand within the lipid bilayer, it acts locally and is found in all tissues including the brain.

PEA is thought to be produced as a pro-homeostatic protective response to cellular injury and is usually up-regulated in disease states. PEA’s multifaceted effects are due to its unique mechanisms of action that affect multiple pathways at different sites; primarily targeting the nuclear receptor peroxisome proliferator-activated alpha (PPAR-α), PEA also acts on novel cannabinoid receptor, G protein-coupled receptor 55 (GPR55) and G protein-coupled receptor 119 (GPR119). Moreover, it indirectly activates cannabinoid receptors 1 and 2 (CB1 and CB2) through inhibiting the degradation of the endocannabinoid, AEA, a phenomenon known as the ‘entourage effect’. Additionally, PEA activates and desensitizes the transient receptor potential vanilloid receptor 1 (TRPV1) channels. PEA-containing products are already licensed for use in humans (generally 1,200 mg/day) as a nutraceutical, a food supplement, or a food for medical purposes, depending on the country. PEA is especially used in humans for its analgesic and anti­inflammatory properties and has demonstrated high safety and tolerability. In the last decade, several studies suggested that PEA might exert protection against neuroinflammation and neurodegeneration, thus indicating that the compound possesses exceptional potential as a novel treatment for neurodegenerative disorders significant anti­nociceptive effect7

Magnolia (Magnoliaofficinalis)

The bark of Magnolia officinalis is used in Asian traditional medicine for the treatment of anxiety, sleeping disorders, and allergic diseases. Study found that the extract and its main bioactive constituents, magnolol and honokiol, can activate CB receptors8

Commercially available Magnolia bark extracts appear to be marketed based on their high phenolic content, with magnolol and honokiol ranging from 40% to 90% of total polyphenols. Many national in-

stitutions in Europe have given safety approval and included M. officinalis in the herbal preparations list suitable for food supplements.

Echinacea (Echinaceapurpurea and E. angustifolia)

Echinacea is perhaps the best known medicinal plant of North America and has a long and rich cultural history of use. Classic ethnopharmacology research on echinacea, mostly with E.purpurea (L.) Moench and E. angustifolia DC (Asteraceae), has focused mainly on activities such as antimicrobial action and immunomodulation in relation to traditional pharmacopoeial uses for colds and flu.

Recent research has revealed a relevant new mechanism of pain management by echinacea mediated by alkylamides (AKA) acting at the CB receptors (Woelkart et al. , 2005; Raduner et al., 2006; Hohmann et al., 2011). In addition to selectively binding and activating CB2 receptors, certain echinacea AKA can modulate ECS activity through effects on endocannabinoid metabolism and transport11

Alkylamides have been shown to be effective on CB2, which is thought to be one of the mechanisms behind their immunomodulatory characteristics. Echinacea alkylamides exhibit cannabinomimetic activities on two specific types of G protein­coupled receptors, CB1 and CB2 cannabinoid receptors; this might be owing to structural similarities between them and anandamide, which is a natural cannabinoid receptor ligand.

In contrast to the psychoactive effects of CB1 receptor agonists, drugs that act on CB2 receptors appear as promising drugs to fight inflammatory diseases. The CB2 receptor is located mainly in the periphery, especially in the blood cells and in the organs that produce blood cells. Recently, the results reconfirmed the agonist activity of alkylamide derivatives, which demonstrates selectivity for CB2. Other research found that TNF expression was revealed to be modulated by alkylamides found in Echinacea extracts. In human monocytes and macrophages, Echinacea extracts modulate mRNA through the CB2 receptor, as well as inhibition of stimulated LPS and TNF-α. Based on these data, extracts derived from E. purpurea support the promise of anti­inflammatory and anti­pruritic benefits. It is known that the endocannabinoid system regulates several parts of the immune functions and the skin barrier; therefore, targeting it may be a viable method of reducing the symptoms of atopic eczema.

Cannabinomimetic properties are also important for anxiolitic effect. Echinacea medicines were tested for anxiolytic efficacy among animals used in studies at reduced concentrations as compared to those that utilized unconventional applications. There is little information available about Echinacea and anxiety, but in the future, it will be possible to do research to prevent or even treat anxiety12

LCPUFA

N-6 and n-3 long-chain polyunsaturated fatty acids (LCPUFA) are essential components of membrane phospholipids and also precursors to a large and ever-expanding repertoire of bioactive lipid mediators. The brain is highly enriched in the n-6

PUFA, arachidonic acid (ARA), and the n-3 PUFA, docosahexaenoic acid (DHA), with both essential for optimum brain development and function. Elevated dietary intake of DHA and eicosapentaenoic acid (EPA), another n­3 LCPUFA, has beneficial effects on learning and memory, decreases neuroinflammatory processes and enhances synaptic plasticity and neurogenesis.

ARA is the precursor to a wide range of mediators, including the two major endocannabinoids in the brain. Thus, there is considerable overlap in the effects of n-3 PUFA and the endocannabinoid system. ARA and DHA are the two main PUFA in the brain. These LCPUFA can be supplied either preformed from the diet or synthesised in the liver from their shorter chain precursors, linoleic acid (LA, 18:2n-6) and α-linolenic acid (ALA, 18:3n-3). n-6 and n-3 PUFAs are also precursors to endogenous ligands of the endocannabinoid receptors. Due to their fundamental nature, ARA, DHA, EPA and their mediators and the endocannabinoid system have wide-ranging effects across the CNS and recent evidence strongly indicates a complex interplay between them. The levels of phospholipid-bound ARA determine the levels of 2-AG and AEA, which in addition to their own biological activities act as reservoirs of ARA for subsequent eicosanoid production9

Amount of ω-3 and ω-6 PUFAs provided by food has direct consequences on their bioavailability and it has been established that the ideal ratio in the diet is of about 5:1 of ω-6:ω-3 PUFAs precursors. However, our modern diet is hugely unbalanced with an estimated average ratio of 20:1. The dietary deficit in ω-3 PUFAs has been associated with numerous diseases, and it becomes evident that an imbalance of ω-3/ω-6 PUFAs in the brain is linked to several neurological and neuropsychiatric disorders .

2-AG and AEA, these two canonical endocannabinoids are derived from the ω-6 PUFA ARA and most of studies have focused on these endocannabinoids. However, more and more studies are highlighting the role of ω-3-derived endocannabinoids. These species are agonists of CB1 and CB2 receptors, but their role in neuroplasticity is yet to be unravelled.

Briefly, there is a two­step process to form endocannabinoids from phospholipids. Endocannabinoids are made on demand and they are rapidly degraded, back into PUFAs or oxidized into active metabolites.

Generally, the conclusion from the studies10 is that modulating dietary PUFAs inevitably modulates levels of endocannabinoids in the organism. In addition, it often emerges from these studies the idea that it exists ‘good endocannabinoids’ and ‘bad endocannabinoids’. In this concept, ARA-derived endocannabinoids need to be down-regulated in pathological states (obesity, inflammation, etc.), and a diet rich in ω-3 decreases the levels of ARA-derived endocannabinoids (the ‘bad’ one), in favor to ω-3-derived endocannabinoids (the ‘good’ one). This appealing hypothesis needs to be studied because the presence of ω-3derived endocannabinoids in the organism is known, but their function remains to be fully investigated. In conclusion, dietary ω-6/ω-3 PUFAs appear as potent modulators and homeostatic regulators of endocannabinoids in the brain. The consequences of this modulation need to be investigated to under-

stand its putative role in brain health and diseases (in particular those with endocannabinoid impairment) and develop future therapeutics to target the endocannabinoid system through dietary ω-6/ω-3 PUFAs. The most promising hypothesis that needs to be explored, the opinion is that dietary PUFAs could switch the system from ‘bad’ (ω-6-derived) endocannabinoids to ‘good’ (ω-3-derived) endocannabinoids10

Conclusion

In conclusion, the endocannabinoid system (ECS) plays a pivotal role in maintaining homeostasis and regulating various physiological processes, including pain, inflammation, mood, and memory. With its complex receptors, ligands, and enzymes network, the ECS is a crucial target for therapeutic interventions, particularly in neurological and immune-related disorders. Ongoing research into phytocannabinoids, synthetic cannabinoids, and other plant-derived compounds continues to uncover promising avenues for treatment, highlighting the ECS's potential in developing novel, effective therapies for a wide range of conditions.

References:

1 Lutz B. (2020). Neurobiology of cannabinoid receptor signaling Dialogues in clinical neuroscience, 22(3), 207–222. https://doi. org/10.31887/DCNS.2020.22.3/blutz

2 Svízenská, I., Dubový, P., & Sulcová, A. (2008). Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures--a short review. Pharmacology, biochemistry, and behavior, 90(4), 501–511. https:// doi.org/10.1016/j.pbb.2008.05.010

3 Turu, G., & Hunyady, L. (2010). Signal transduction of the CB1 cannabinoid receptor. Journal of Molecular Endocrinology, 44(2), 75-85. Retrieved Oct 14, 2024, from https://doi.org/10.1677/JME-08-0190

4 McCarberg, Bill H MD1*; Barkin, Robert L MBA, PharmD, FCP2. The Future of Cannabinoids as Analgesic Agents: A Pharmacologic, Pharmacokinetic, and Pharmacodynamic Overview. American Journal of Therapeutics 14(5):p 475-483, September 2007. | DOI: 10.1097/MJT.0b013e3180a5e581

5 https://www.rmmj.org.il/issues/18/Articles/298

6 Rezende B, Alencar AKN, de Bem GF, Fontes-Dantas FL, Montes GC. Endocannabinoid System: Chemical Characteristics and Biological Activity. Pharmaceuticals (Basel). 2023 Jan 19;16(2):148. doi: 10.3390/ph16020148. PMID: 37017445; PMCID: PMC9966761.

7 Beggiato, S., Tomasini, M. C., & Ferraro, L. (2019). Palmitoylethanolamide (PEA) as a Potential Therapeutic Agent in Alzheimer's Disease. Frontiers in pharmacology, 10, 821. https://doi.org/10.3389/ fphar.2019.00821

8 Rempel, V., Fuchs, A., Hinz, S., Karcz, T., Lehr, M., Koetter, U., & Müller, C. E. (2012). Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55. ACS medicinal chemistry letters, 4(1), 41–45. https://doi. org/10.1021/ml300235q

9 Dyall S. C. (2017). Interplay Between n-3 and n-6 Long-Chain Polyunsaturated Fatty Acids and the Endocannabinoid System in Brain Protection and Repair. Lipids, 52(11), 885–900. https://doi. org/10.1007/s11745-017-4292-8

10 Bosch-Bouju C, Layé S. Dietary Omega-6/Omega-3 and Endocannabinoids: Implications for Brain Health and Diseases [Internet]. Cannabinoids in Health and Disease. InTech; 2016. Available from: http://dx.doi.org/10.5772/62498

11 Liu, R., Caram-Salas, N. L., Li, W., Wang, L., Arnason, J. T., & Harris, C. S. (2021). Interactions of Echinacea spp. Root Extracts and Alkylamides With the Endocannabinoid System and Peripheral Inflammatory Pain. Frontiers in pharmacology, 12, 651292. https://doi. org/10.3389/fphar.2021.651292

12 Burlou­Nagy, C., Bănică, F., Jurca, T., Vicaș, L. G., Marian, E., Muresan, M. E., Bácskay, I., Kiss, R., Fehér, P., & Pallag, A. (2022). Echinacea purpurea (L.) Moench: Biological and Pharmacological Properties. A Review. Plants (Basel, Switzerland), 11(9), 1244. https://doi. org/10.3390/plants11091244

RESEARCH: Health Claims Strongly Influence Younger Consumers

Prinova's research shows that health claims, especially about gut health and energy, strongly influence younger consumers, with 87% of 18-24-year-olds more likely to buy products with such benefits.

Global ingredient supplier Prinova surveyed over 1500 adult consumers in Europe and the US.* Seventy-two per cent said they were more likely to buy a food or beverage product if the packaging mentioned a health benefit. However, this rose to 87% among those aged 18 to 24, and to 80% among those aged 25 to 34.

Overall, the claims most likely to influence purchasing decisions were low-sugar or sugar-free, weight management and energy support. The ingredients most likely to influence purchasing decisions were probiotics, vitamins and minerals and fibre, while the concerns most likely to affect food and beverage purchases were gut health, healthy ageing and fatigue.

James Street, Global Marketing Director at Prinova, said: “There’s a long­term trend towards more proactive approaches to wellbeing, with dietary changes a key element of consumers’ strategies for living better. As a result, they’re increasingly seeking out food and beverage products with health benefits. Our research demonstrates the value of well communicated health claims, especially in key areas like gut health and energy support. While they resonate powerfully across all demographics, our research provides new evidence that zoomers and millennials are particularly likely to focus on wellness when choosing between products.”

The research also reveals high levels of interest in

personalised approaches to nutrition. Seventy-nine per cent of respondents believed that their particular genetic make­up affected their nutritional needs either slightly or significantly, with millennials and women particularly likely to agree.

Forty-one per cent were keen to try a test that monitored how particular foods affected their bodies, while 32% were interested in tracking their diet and nutrition through an app or questionnaire. Thirty per cent of respondents overall, and 37% of those aged 25-34, were interested in wearable devices to monitor their blood sugar levels.

Sixty-six per cent of the consumers surveyed played video games at least once a week, and 61% of these said they used food or nutrition products to improve their gaming performance. The ingredients most associated with superior performance were caffeine, B vitamins and ginseng.

Prinova is a leader in categories like amino acids, plant proteins, sweeteners and vitamins. Its branded ingredients include enduracarb® trehalose, a slowrelease carbohydrate designed to provide sustained energy, and LactoSpore®, a clinically validated shelfstable probiotic.

Download the full report at: https://tinyurl.com/yyksms7p

* Survey of 1,582 consumers in France, Germany, Italy, Spain, the UK and the US. Conducted online in June 2024.

Groundbreaking Research on the Impact of Lutein and Natural Zeaxanthin on Maternal and Infant Health

First National Institutes of Health-funded clinical study on pregnant moms and babies supplemented with FloraGLO® Lutein and Optisharp™ Natural Zeaxanthin shows significant improvement in carotenoid levels.

Kemin is proud to support a newly published study on the use of FloraGLO® Lutein and Optisharp™ Natural Zeaxanthin in prenatal supplements, showing that carotenoid levels improve for both mothers and their newborn infants. Published in the September 2024 issue of Ophthalmology Science , this study emphasizes the potential of these carotenoids in supporting both mothers and their infants.

Building on more than a decade of Kemin’s research and nearly 20 peer-reviewed publications in moms and babies, the LuteinandZeaxanthininPregnancy (L-ZIP) clinical trial, led by Dr. Paul S. Bernstein at the John A. Moran Eye Center of the University of Utah, was designed to address the question as to whether lutein and zeaxanthin should be added to standard-of-care prenatal vitamins for expecting mothers. Funded by the National Institutes of Health prestigious National Eye Institute, the clinical trial provided 10 mg FloraGLO Lutein and 2 mg Optisharp Natural Zeaxanthin to healthy pregnant women throughout the course of their pregnancy. Results showed statistically significant and clinically important increases in maternal and infant systemic and ocular carotenoid levels following supplementation, demonstrating that prenatal supplementation is both safe and effective in enhancing the health of mothers and infants.

“The significant findings of improved carotenoid status in both mom and baby, as well as the improvement in the infant’s eye development, provide compelling evidence that lutein and zeaxanthin should become standard of care for all pregnant women,” said Brenda Fonseca, Global Technical Services Lead, Kemin Human Nutrition & Health. “Most prenatal supplements and infant formulas currently lack lutein and zeaxanthin, but this research highlights their crucial role and potential long­lasting benefits

on maternal and infant health. Kemin is proud of its role in this remarkable study.”

Key findings of the L-ZIP study:

• Efficacy of FloraGLO Lutein and Optisharp Natural Zeaxanthin supplementation in significantly increasing maternal and infant carotenoid levels Safety of FloraGLO Lutein and Optisharp Natural Zeaxanthin in prenatal supplementation

• Improved foveal maturity in infants from supplemented mothers, a marker of ocular development and function

“From the infants’ perspective, the bioavailability of lutein and zeaxanthin could potentially provide an early start for their lifelong physiological and protective roles for the developing retina and infant vision,” said Dr. Emmanuel Kofi Addo, John A. Moran Eye Center at the University of Utah. “The clinical relevance of differences in foveal maturity observed in our study lies in the potential long­term benefits for visual and cognitive development. Enhanced foveal maturity may improve infant visual acuity and contrast sensitivity. Thus, a well-developed fovea is essential for sharp central vision and is critical for recognizing faces as children grow.”

Despite growing evidence on the essential role of lutein and zeaxanthin in eye and brain health, most prenatal supplements and infant formulas still lack these nutrients. Given the low intake of fruits and vegetables - the primary sources of these carotenoids - there is a critical need for supplementation to fill this nutritional gap. “Our study prospectively showed that prenatal carotenoid supplementation considerably enhanced maternal and infant carotenoid status,” added Dr. Addo. “Since our bodies do not produce these molecules, it is crucial for maternal intake of lutein and zeaxanthin as this is the only source infants receive.”

The L-ZIP study, the 18th peer-reviewed publication using FloraGLO Lutein in maternal and infant health, highlights the Kemin commitment to advancing early life nutrition and paves the way for future recommendations on including these vital nutrients in prenatal and infant products.

Click here to access the publication from the September 2024 issue of Ophthalmology Science. Click here to learn how FloraGLO Lutein impacts maternal and infant health.

lnflamrnation in the body can result from physical or athletic exertion. And while a crucial and useful biologica I proces�, such chronic respon�es can damage tissue and cause injuries, leading to various conditions. Because it's composed exclusively of THC s - the major active metabolites of curcumin - C3 Reduct ® delivers anti-inflammatory properties that hold significant promises in protecting and soothing joints and muscles.

EU Import License for Organic Spirulina

Parry Nutraceuticals has been issued with a European Union import licence for organic Spirulina – the first to be granted to an Indian company in nearly two years.

In October 2022, the European Commission delisted a number of Indian organic certification bodies after detecting traces of the EU-banned pesticide ethylene oxide in a shipment of organic sesame seeds from India. Among the organisations affected by this move was the sole control body in the world authorised to certify organic microalgae from India, putting an indefinite stop to imports of organic Spirulina into the EU from India.

Following the European Commission’s decision, Chennai-based Parry Nutraceuticals - which produces only Spirulina that is certified organic ­ began the search for a Europe-based body willing to develop the capacity to certify organic Spirulina from India. Having successfully identified a recognised, credible European partner, and after more than a year of hard work behind the scenes, Parry Nutraceuticals is in a position to resume exports to the EU with immediate effect.

Baburaj Lakshmi Kanthan, Parry Nutraceutical’s Head of Business, welcomed the news. “It was a long process - much longer than we’d hoped for - but we are delighted to be back in the EU,” he said. “We thank our customers for their loyalty and patience during this delay and we look forward to working with them again.”

During its absence from the EU in the past two years, Parry Nutraceuticals has invested considerably in research and development and will re-enter the European market with new, improved versions of its organic Spirulina powders and tablets. These are manufactured using the innovative Tuymai filtration process. This preserves Spirulina’s cell structure, in turn enhancing its purity and organoleptic profile, and increasing the levels of phycocyanin in the powder. Phycocyanin is a powerful bioactive associated with health benefits including muscle recovery and immunity.

Rajendran Lingan, Head of Quality Assurance at Parry Nutraceuticals, commented: “We have been very busy during our temporary absence from the EU market, and we are excited to offer the latest version of our superior quality Spirulina to our European customers. We are one of only two Spirulina producers worldwide with two separate Organic Certifications. In addition to EU Organic status, we also now hold certification from the even more stringent Naturland, which is a gold-standard European scheme demonstrating that we are compliant with the most exacting ecological and social sustainability standards. We are also the only microalgae producer with USP verification ­ and our con-

taminant levels are three to five times lower than current EU regulatory requirements.”

Parry Nutraceuticals supplies Spirulina in a range of forms, including granules, which are a flexible option for a variety of applications such as food and beverage, food supplements, and cosmetics and personal care. The company is also a leading manufacturer of white-label Spirulina tablets, which are supplied ready for health and wellness companies to package, brand and sell as their own supplements. Parry Nutraceuticals’ sales to the US and Asia were unaffected by the EU’s decision and have continued to perform strongly during its absence from the European market.

Sofia Hoffmann de Mendonça, European Business Development Manager for Parry Nutraceuticals, said: “The absence of our organic Spirulina from the European market has been frustrating not only for the Parry team but also for our customers and distributors. They previously had access to organic Spirulina products with the best quality-price ratio in Europe but found themselves left with no comparable alternative. We are delighted that we can now return to the EU market to serve our current customers - and new ones - and once again deliver the great-quality, unique, and competitively priced Spirulina that we are well known for.”

Parry Nutraceutical’s Spirulina is produced in a natural, rural environment in the south of India, in compliance with the strictest certifications. The company has also invested extensively in research to support health claims specific and exclusive to its own Spirulina, offering an added­value selling proposition in the global market.

Find out more about Parry Nutraceuticals in this new video: https://youtu.be/dNY7f8nP7Ro.

Parry Nutraceuticals’ microalgae raceway ponds, located in the south Indian countryside. Image credit: ©Parry Nutraceuticals.

Gelita Showed Manufacturers How To ‘Make It Better’

At Fi Europe 2024, Gelita showcased its innovative gelatin and collagen peptide solutions, highlighting how they can enhance the nutritional value, sensory experience, and production efficiency of bars, gummies, and supplements.

At Fi Europe 2024, Gelita demonstrated how its gelatin and collagen peptide solutions can elevate bars, gummies, supplements, and more. The collagen innovator showcased multiple ways in which its tailored ingredients helped manufacturers raise the bar in food and supplement production, from increasing protein content and reducing sugar levels, to adding scientifically proven health functionality. A 60% protein bar made with Optibar®, fiber-rich gummies formulated with Soluform®, and beauty-from-within gummies including Verisol® HST and Confixx® were among the innovative concepts presented at booth H3.1 F50.

Oliver Wolf, Marketing at Gelita, said: “We are constantly looking for ways of leveraging our collagen expertise to help our customers take their products to the next level. At Fi Europe, we showcased some of the solutions we have conceived, which is why we designed our booth around the theme of ‘making it better.’ We were extremely excited to show visitors how they could go above and beyond what is thought to be possible with bars, gummies, and supplements, not only from a nutritional and sensorial perspective but also in terms of efficacy and production efficiency.”

Better bars with Optibar®

Optibar® is a collagen peptide that can help manufacturers formulate bars that meet the demands of increasingly health-conscious consumers. In nutrition bars, balancing a high protein content with a desirable taste and texture is difficult. Optibar® enables more protein to be incorporated into bars - a protein content of up to 65 percent is possible whilst maintaining a soft and indulgent texture. Optibar® can also act as a sugar-free binding system in cereal bars, allowing manufacturers to simultaneously rai-

se the protein content and lower the sugar content.

Better gummies with Soluform® and Confixx®

Soluform® is Gelita’s next generation gelatin for optimizing the nutritional profile of confectionery products, including gummies, hard-boiled sweets, marshmallows and chewy candies. Soluform®PE can increase the protein content, whilst Soluform®SR enables the production of reduced sugar and sugarfree candy without compromising on taste and texture. Confixx® is a fast-setting gelatin that represents a breakthrough in fortified gummy production. This new gelatin enables the starch-free production of gummies with a sensorial profile that has previously only been attainable with a starch-based manufacturing process.

Better supplements with Bioactive Collagen Peptides

Manufacturers looking for science-backed ingredients for sports nutrition and functional health products need look no further than Gelita’s Bioactive Collagen Peptides (BCP®). Each BCP® ingredient is customized to target a specific part of the body, including skin, joints, bones, ligaments, tendons and muscles. Verisol®, for example, has been developed to deliver the highest levels of efficacy in human skin. Its positive effects on skin metabolism have been proven in a number of clinical human trials and the ingredient is currently proving popular for beautyfrom-within concepts. Visitors will be able to sample tea and mocktails fortified with Verisol®, as well as gummies formulated with Verisol® HST - a solution specifically designed for collagen­rich gummies.

Better ingredient delivery: controlled release softgel gelatins

Recognizing that one size definitely doesn’t fit all when it comes to gelatins for softgel capsule production, Gelita has developed a portfolio of tailored gelatins that have different fill release profiles and address specific challenges. Rapisol® is a fast release solution, whereas Delasol® offers delayed release, important for ensuring the efficacy of active ingredients such as omega-3 oil, krill oil, essential oils and probiotics. The RXL® portfolio tackles the issue of crosslinking, improving stability over an extended shelf life, and Easyseal® is a new solution that enhances process efficiency by reducing leakage.

expert insights

Miguel Jiménez Del Río, CEO of Nektium

Miguel Jiménez Del Río, CEO of Nektium, leads one of the foremost companies in the botanical extracts and nutraceuticals industry. In this interview, Mr. Jiménez Del Río shares insights into the key factors behind the company’s success, the role of clinical research and ethical sourcing, and the major trends shaping the market.

n What key factors have contributed to Nektium’s success in the botanical extracts and nutraceuticals industry?

Nektium's success is driven by our Consumer-Centric Product Development strategy based on our ability to understand and anticipate the evolving needs of our customers, allowing us to develop ingredients that cater to specific health and wellness concerns.

Nektium’s commitment to delivering high-quality, scientifically validated ingredients, combined with a focus on innovation and sustainability has been key to develop and market our diverse portfolio, which includes branded ingredients like Zynamite® (which PX version has been recognized with the most prestigious awards in our industry), Rhodiolife®, Vanizem® (recently launched globally, the market reception is excellent), and Xanthigen®, along with our range of botanicals such as Elderberry and Pomegranate, sets us apart.

More in detail, at Nektium, we prioritize the highest standards of quality by sourcing premium, sustainably harvested botanical ingredients. Our strict quality control processes ensure that our products consistently meet industry regulations and customer expectations. Additionally, we have made substantial investments in R&D, which has allowed us to develop innovative, science-backed formulations that stand out in this competitive market.

Finally, our strategic partnerships have facilitated our expansion into international markets, enabling Nektium to sustain continuous growth and diversify our revenue streams while increasing our global footprint.

n What role do clinical trials and scientific research play in the development of your products?

Clinical trials and scientific research are fundamental to our product development process. Every branded ingredient, from Zynamite® to Vanizem®, undergoes rigorous testing to ensure efficacy and safety.

For example, Zynamite® PX has won a NutraIngredients US award due to its scientifically backed performance-enhancing properties.

Similarly, Vanizem®, launched in May 2024, was developed after extensive research into its effects on stress relief and mood improvement. This commitment to clinical validation strengthens our credibility in the industry and provides our customers with trustworthy products.

n Nektium is known for its sustainable practices. Can you walk us through the sourcing process of one of your flagship products, like Rhodiolife®? How do you ensure ethical sourcing?

Sustainability is embedded in every aspect of our operations. Rhodiolife®, for example, is sourced through wild and cultivated harvesting of Rhodiola rosea in the Siberian Altai mountains, where we work closely with local communities. We ensure ethical sourcing by supporting fair wages and sustainable farming practices that preserve the local ecosystem. This approach extends to all our botanicals, including Elderberry and Devil’s claw, where we maintain transparency and traceability throughout

the supply chain to guarantee both quality and sustainability.

n How has the nutraceutical market evolved in recent years, and what consumer trends are you most excited about?

The nutraceutical market has shifted toward a focus on personalized health solutions, driven by consumer demand for natural products that address specific health concerns. Trends like stress management, active aging, and cognitive support are particularly exciting for us, as they align with our product pipeline, including Vanizem® for stress relief and Zynamite® for energy and cognitive function.

The increasing awareness around mental wellness and longevity is also an area we’re eager to explore, as it ties into our commitment to promoting a healthier, more balanced lifestyle.

n How does Nektium stay competitive in a rapidly growing market, especially with new players entering the field?

We maintain our competitive edge by continuously innovating and launching distinctive, clinically validated and branded ingredients that set us apart in the market.

Our approach encompasses the entire product lifecycle, from development to manufacturing, with the highest quality standards, and extends to defining the most effective go­to­market strategy.

Winning industry awards, such as the NutraIngredients US award in 2024 for Zynamite® PX, demonstrates our commitment to excellence and showcases our dedication to producing the highest quality products.

We are convinced this is the most effective way to differentiate ourselves in an increasingly crowded market. We achieve this by investing in R&D, main-

taining sustainable practices and quality standards, taking into account the Voice of Customers, both in the initial product development phase and in the definition of the go­to­market strategy.

n What has been the most rewarding part of your journey with Nektium so far?

The most rewarding part of our journey has been seeing how our ingredients, such as Rhodiolife® and Zynamite®, have made a tangible impact on consumers' health and wellness.

It's incredibly satisfying to see our products recognized with awards, like Zynamite® PX, and to receive positive feedback from customers and partners alike.

Launching innovative solutions like Vanizem® to help people manage stress and improve their quality of life has been particularly fulfilling, knowing we’re addressing real, pressing health concerns.

But, undoubtedly, my greatest pride is to see how over the years in Nektium we have been able to form an excellent team of professionals where commitment, passion for innovation and results orientation are its hallmarks.

n As a leader, what has been your vision for Nektium, and how do you drive that vision forward?

My vision for Nektium is to remain at the forefront of botanical innovation, offering products that are not only scientifically validated but also sustainably sourced and ethically produced.

We drive this vision by continuously investing in research and maintaining a strong focus on developing solutions for pressing global health challenges.

n Is there a final message you’d like to share with our readers about Nektium’s mission and vision for the future?

At Nektium, we are passionate about the potential of botanical ingredients to improve people's lives.

As we look to the future, we are excited about the projects in our pipeline focused on active lifestyle, longevity, and healthy aging. We remain committed to sustainability and ethical sourcing, ensuring that we continue to offer high­quality products while making a positive impact on the environment and the communities we work with.

We are proud of our recent achievements and are looking forward to what lies ahead.

Prepare, Repair, Go!

Products for muscle strengthening and health are becoming popular among a broad demographic, not just athletes, as they help maintain stability, energy, mood, and sleep. Plant extracts such as pomegranate, spinach, and cucumber offer numerous health benefits, including improved muscle strength, cognitive function, and joint health, redefining the sports nutrition segment with natural botanical ingredients.

It is no secret that improving muscle health not only enhances athletic power but also contributes significantly to overall wellness. Therefore, products aimed at building muscle and strength are no longer limited to bodybuilders or athletes.

Strong muscles play a key role in enhancing stability, balance and flexibility, and also have the potential to boost mood, energy levels and sleep. As consumers are becoming aware of these benefits, the sports nutrition category is evolving and now encompasses a broader demographic under the umbrella of “active nutrition”. This group includes not only athletes but also individuals who are interested in maintaining good health. In response to this trend, ingredient suppliers are adapting to cater for the needs of people of all ages and activity levels.

Diverse demands

Some athletes treat their bodies like a finely tuned machine and aim for quick recovery times, whereas others focus mostly on muscle growth. And while men and women may have differing nutritional requirements, they share the same desire to look and feel well, which includes maintaining energy levels and good immune health. Finally, a growing number of e-athletes are looking for products to support energy levels, focus and reaction times. To meet these differing needs, Euromed, a producer of standardised herbal extracts, offers a broad range of botanical ingredients for functional foods and beverages, dietary supplements and other innovative sports nutrition products. The rising popularity of botanical ex-

tracts, known to support muscle health, cognitive skills, endurance and metabolic balance, is reflective of a diverse consumer base, including an older demographic who increasingly understand the importance of supplements for healthy ageing. This trend is significantly influenced by the recognised benefits of the Mediterranean diet, which has long been associated with improved longevity.

The power of polyphenols

Pomanox® is a flagship product from the Mediterranean fruit and vegetable extracts range. With more than 12 published studies and several ongoing clinical trials, the pomegranate extract, which is rich in polyphenols including punicalagin, meets growing consumer demand for active ageing. With its high antioxidant and anti­inflammatory properties, the polyphenols help improve a range of performance parameters, including increased endurance, distance covered in a pre-selected time period, time to complete a certain distance and maximum power output, in both untrained but particularly trained male athletes.1

A randomised, placebo-controlled clinical study demonstrated improvement in peak performance and recovery after an exhausting endurance trial in trained amateur cyclists who had consumed the pomegranate extract. 2 The main outcomes show that 14 days of supplementation significantly increased time to exhaustion and time to reach ventilatory threshold 2 (VT2) in a maximal test following sustained endurance effort, compared with a placebo. According

to the authors, this means that both maximal and submaximal performance increased. Additionally, 72 hours after the trial, inflammatory markers were lower in the Pomanox® group, suggesting faster recovery. Other published studies indicate that the pomegranate extract may support mood and, within just one hour, improve aspects of cognitive performance such as visual memory. 3,4

Supporting active lifestyles

In addition to pomegranate, there are further evidence-based fruit and vegetable extracts that are inspired by the healthy ageing properties associated with the Mediterranean Diet. For instance, spinach extract Spisar® has shown positive effects on skeletal muscle strength and muscle fitness in subjects aged 50-plus who combined moderately intense training with 12-week daily supplementation of Spinacia oleracea L. extract.5 Spinach leaves have a naturally high content of phytoecdysteroids, plant secondary metabolites with a wide range of potential health benefits, such as improved physical performance and enhanced stress resistance. The authors conclude that the spinach extract in conjunction with physical exercise may exert overall “all­body strengthening” adaptogenic activity, and may be beneficial for improving muscle fitness and maintaining muscle health, both of which are crucial for active ageing. Yet strong joints are important too, as they support mobility. Researchers have found that supplementation with the cucumber extract CuberUp® may help enhance joint health6, with the results of a doubleblind clinical study linking it to significantly improved quality of life for those suffering from osteoarthritis in the knee. Subjective sensation of knee pain improved significantly in both study groups, but improvements were higher in the CuberUp® group. Pain reduction was fast, starting from week 1 and becoming significant versus placebo by week 4. In addition, a reduction in pain and stiffness, together with improved physical function, were significantly more pronounced in those receiving the cucumber extract. Amino acid derivatives in cucumber extracts possess anti­inflammatory properties and may also improve cartilage nutrition. Moreover, flavonoids and tannins in the phytochemical composition of aqueous fluid cucumber extracts may be responsible for their free radical scavenging and analgesic effects. Another promising botanical ingredient for Healthy Agers and athletes is ABAlife® – an abscisic acid­enriched fig extract which has been shown to improve insulin sensitivity and glycemic control for effective energy use in muscles.7,8 It offers a promising solution for individuals seeking to maximise their energy levels and performance during physical activities. The fig extract helps facilitate the transport of glucose into muscle cells, where it is efficiently converted into energy. This mechanism not only supports athletic performance but also aids the maintenance of stable blood sugar levels, contributing to overall metabolic health.

Beyond muscle

Sports and active nutrition increasingly encompass support for sustained mental performance, too, driven by the burgeoning popularity of gaming and

e-sports. This trend enables manufacturers to tap into new audiences, as e-athletes must maintain peak mental and physical performance for several hours of continuous gaming during competitions. Their particular needs include improved concentration and reactivity to fatigue prevention, as well as relief from headaches and eye strain. Offering evidence-based support for cognitive performance and eye health9, pomegranate extract is a real botanical all-rounder. It has shown cortisol-lowering properties in two clinical studies, further supporting anti-catabolic and stress-relieving potential. 3,10 Likewise, melissa leaf, lime flower, passionflower and valerian root present promising ingredients for e-athletes thanks to their stress management properties. However, the market still lacks a significant number of gaming­specific nutrition products tailored to the diverse needs of e-athletes, thus presenting ample opportunities for manufacturers to develop targeted solutions for this segment.

Holistic thinking

From fitness enthusiasts and Healthy Agers to e-athletes, many people seek nutritional supplementation for simultaneous energy, performance and recovery support. While health benefits are a major factor, sustainability and naturalness are other key drivers. As the active nutrition category becomes increasingly popular, manufacturers should use clinically researched ingredients to provide consumers with the highest quality products. The inclusion of functional ingredients such as botanical extracts is therefore essential for the creation of brands that not only enhance fitness, but also overall health and wellbeing.

References:

1 Somerville V., et al.: Polyphenols and Performance: A Systematic Review and Meta-Analysis. Sports Med. 2017, 47, 1589–1599.

2 Torregrosa-García A., et al.: Pomegranate Extract Improves Maximal Performance of Trained Cyclists after an Exhausting Endurance Trial: A Randomised Controlled Trial. Nutrients 2019, 11(4), 721.

3 Stockton A, AL-Dujaili EA, MCDougall G, Davidson I, Drummond S, Wyness L. Effect of pomegranate extract consumption on cardiovascular disease risk factors, stress hormones, and quality of life in human volunteers: an exploratory randomised, double-blind, placebo-controlled trial. EC Nutr 2015;4(5):396e411.

4 Stockton, A. V. E., Zangara, A., & Al-Dujaili, E. A. S. (2021). Investigating the acute effect of pomegranate extract on indicators of cognitive function in human volunteers. Nutraceuticals in Brain Health and Beyond, 141–154.

5 Pérez-Piñero, S.et.al (2021): A 12-Week Randomized Double-Blind Placebo­Controlled Clinical Trial,Evaluating the Effect of Supplementation with a Spinach Extract on Skeletal Muscle Fitness in Adults Older Than 50 Years of Age. Nutrients 2021, 13, 4373.

6 Pérez­Piñero, S. et al.: Effectiveness of a Cucumber Extract Supplement on Articular Pain in Patients with Knee Osteoarthritis: A Randomized Double-Blind Controlled Clinical Trial. Appl. Sci. 2023, 13, 485. https://doi.org/10.3390/app13010485

7 Atkinson FS et al.: Nutrients. Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults. 2019 Jul 31;11(8). pii: E1757.

8 Leber, A., et al. Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle. Sci Rep 10, 10463 (2020).

9 Peñalver­Mellado, M. et al. In Vitro Anti­Inflammatory Potential of Pomegranate Extract (Pomanox®) in a Reconstituted Human Corneal Epithelium Model. J. Clin. Transl. Ophthalmol. 2023, 1, 52-60

10 Al­Dujaili, E.A.S. et al. Antioxidant Properties and Beneficial Cardiovascular Effects of a Natural Extract of Pomegranate in Healthy Volunteers: A Randomized Preliminary Single-Blind Controlled Study. Antioxidants 2022, 11, 2124

Vitaquest Says Chewable Tablets Outperform Gummies in Growing Supplement Market

Compared head-to-head, chewable tablets offer better dosage control, absorption, stability, and taste, among other advantages.

Vitaquest International, an industry-leading contract development and manufacturing organization, has identified chewable tablets as a superior supplement delivery format compared to gummies.

With up to 40% of people struggling to swallow pills, consumers are increasingly seeking alternatives. While the gummy supplement market is projected to reach $12.4 billion by 2031, sales of chewable vitamins and supplements are expected to reach $6.3 billion by 2027. Despite this slower projected growth, Vitaquest research confirms that chewable tablets offer clear advantages over gummies, including better dosage control, absorption, stability, and taste.

When comparing the two delivery formats, chewable tablets are specially formulated to deliver vitamins, minerals, and other nutraceuticals effectively. In contrast, gummies are confectioneries made with ingredients like corn syrup, sucrose, gelatin, starch, food acids, along with various coloring and flavoring additives. While both formats aim to provide nutritional benefits, their formulations differ significantly, and that’s what tips the scales in favor of chewable tablets.

“Chewable tablets hold several advantages over gummies. Chewable tablets offer better stability, are less sensitive to heat, have lower sugar content, and provide a wider range of flavor options,” says Terry Coyle, Chief Innovation Officer at Vitaquest,

“Additionally, they can deliver higher doses of nutraceuticals per serving, require a lower minimum order quantity, and have lower manufacturing costs and production times. Chewable tablets are also more suitable for all age groups.”

Why are chewable tablets better than gummies?

Higher potency and dosage control

Chewable tablets appeal to both adults and children and can come in different shapes and sizes, making them visually appealing and easy to dose. Their adjustable size also allows for more active ingredients, delivering higher potency compared to standard gummies.

Due to the ingredients that make up gummies, there’s less room to include nutraceuticals. In fact, Alcimed reports that it is difficult to make gummies with more than 10% active ingredients by weight, whereas Vitaquest can create chewable tablets that contain up to 50% active ingredients by weight.

The difference in the two delivery formats is illustrated when comparing popular brands of children’s multivitamins:

• Two­tablet serving of a chewable has: five calories, two grams of carbohydrates, less than one gram of sugar, and 100% or more of the daily allowance of all vitamins.

• Two-gummy serving: 15 calories, four grams of

carbohydrates, two grams of sugar, less than 60% daily allowance of most vitamins.

• Versatility and stability

According to Systemic Reviews in Pharmacy, chewable tablets combine the manufacturing and stability advantages of solid dosage products with beneficial flavor and administration features. They can be manufactured using direct compression, a process ideal for moisture- and heat-sensitive ingredients, helping to maintain the stability of nutrients.

Gummies are produced using one of the following manufacturing methods. The first is to spray the nutrients on the finished gummy. That means the nutrients may fall to the bottom of the bottle/packaging, or it could come off on the hands of people, resulting in the consumer not receiving the full amount of nutrients. The other method involves directly incorporating nutrients into the gummy mixture, which requires the gummy to be maintained at a relatively high temperature. This introduces the risk for nutrient degradation due to heat exposure, especially for heat-sensitive nutraceuticals such as probiotics.

It’s important to note that gelatin-based gummies can melt and lose their shape when exposed to temperatures above 90°F (32,222°C). Once cooled, they may form sticky, gelatinous clumps that are difficult to consume. This poses a significant challenge, especially since large retailers often store supplements in warehouses where temperatures regularly exceed 100°F (37,778 °C).

Mouthfeel and taste

Chewable tablets provide a superior mouthfeel, with the ability to deliver a soothing, cooling effect and a smooth texture. On the other hand, many consumers find the texture of gummies less pleasant, an important consideration for children and adults. Elderly consumers with dentures may find gummies’ stickiness objectionable.

Chewable tablets are also available in a wider range of flavors beyond the standard fruit options offered by gummies, including chocolate, vanilla, and caramel, which are difficult to replicate in gummy form.

Manufacturing timeframe and costs

On average, chewable tablets being manufactured for the first time can be developed within 1216 weeks from the time a purchase order is placed, compared to gummies, which can take twice as long to produce. Additionally, the minimum order quantity (MOQ) for chewables is often lower - around 4,100 bottles, compared to up to 30,000 bottles for gummies, allowing supplement brand owners to invest less money upfront.

Sugar content and additives

While gummies rely on sugar or sugar syrups for both sweetness and structural integrity, chewable tablets don’t require these ingredients to maintain their form. Gummies often need additional citric or malic acid to maintain their acidic pH and structural stability, while chewables can be formulated without extra sugars or acids.

For more information: https://vitaquest.com/chewable-tablets-vs-gummies/

New In Vitro Study Demonstrates Superior Absorption of Chelamax® Magnesium

Innophos' new whitepaper reveals that Chelamax® magnesium bisglycinate and magnesium citrate show superior absorption compared to magnesium oxide. The study highlights the benefits of chelated magnesium for more bioavailable supplements.

Innophos, a leading producer of minerals for the nutrition industry, has released a new whitepaper highlighting the results of an in vitro study that demonstrates the superior absorption of Chelamax® magnesium bisglycinate and magnesium citrate. These findings underscore the benefits of chelated magnesium in developing highly absorbable magnesium supplements.

"This whitepaper presents scientific evidence from our latest in vitro study, showing that Chelamax® chelated magnesium delivers superior absorption in the gastrointestinal tract compared to magnesium oxide and a leading competitor's product," said Karen Winkowski, Ph.D., Vice President of Innovation at Innophos. "With our broad range of magnesium products, manufacturers can formulate supplements with improved bioavailability in capsules, tablets, or gummies."

The in vitro study compared the bioaccessibility and bioavailability of Chelamax® chelated magnesium against other magnesium sources, such as inorganic magnesium oxide and a competitor's product. Results revealed significantly higher absorption rates for Chelamax® magnesium bisglycinate and magnesium citrate. The whitepaper provides insights on:

Growing demand for magnesium supplements

• The advantages of increased absorption in Innophos' magnesium products compared to magnesium oxide

• Performance comparisons between Chelamax® and Albion® magnesium bisglycinate.

Innophos' rigorous research and development, including in vitro digestion model studies, confirm the superior absorption of its magnesium products. Offering a variety of magnesium forms for different applications, Innophos also provides technical and formulation support to customers. Chelamax® chelated minerals are supported by an industry­leading 3­step verification process to ensure product quality and integrity. Innophos remains committed to delivering the highest quality, science-backed products, setting new standards in the nutrition industry for validation, transparency, and innovation.

Download the whitepaper and learn more about how to formulate highly absorbable magnesium supplements here

Lipid-based Novel Formulations are Advancing Menopause Management

Menopause marks the end of a woman’s reproductive years and is characterized by the cessation of menstruation, typically occurring between the ages of 45 and 55. Lipid formulations and advanced drug delivery methods, such as bilosomes and liposomal systems, offer promising strategies for improving menopause symptoms.

AUTHOR: Arun Kedia, Managing Director, VAV Lipids

Menopause is usually diagnosed clinically when a woman hasn't menstruated for a year due to a decline in ovarian follicular activity. This condition can generally occur around 45–55 years of age.

In India, there are approximately 150 million women experiencing menopause, as per data shared by the Indian Menopause Society (IMS). The average age of menopause in the country is 46.2 years, as compared to the global average of 51 years.

Menopause is not a sudden event but occurs over several years. Moreover, the hormonal shifts linked to menopause can impact the physical, emotional, mental and even social well-being of women. A survey conducted last October to coincide with World Menopause Day pointed out that 79% of Indian women feel that menopause has a significant impact on their mental and physical well-being.

Menopause can potentially affect the quality of life

Symptoms experienced during and post the me-

nopausal transition vary significantly from person to person, with some experiencing minimal or no symptoms while others facing severe ones that disrupt daily activities. As per the World Economic Forum, in the UK alone, it is estimated that 14 million working days are lost annually due to menopause and perimenopause. As many as 1 in 10 women experiencing menopausal symptoms resign from their positions at work.

Some common symptoms include hot flushes and night sweats, characterized by sudden sensations of heat in the face, neck, and chest. The physical discomfort, often accompanied by skin flushing, sweating and palpitations, can last several minutes. Other symptoms include menstrual irregularity and flow changes, leading to eventual cessation. Vaginal dryness, painful sexual intercourse and incontinence, insomnia, mood changes, depression and anxiety, are also associated with menopause. Sometimes, bone density is lost, contributing to higher rates of osteoporosis and fractures.

There are also unfavourable shifts in the lipid profile, indicated by a rise in low­density lipoprotein

cholesterol (LDL-C) and triglycerides, alongside a decline in high-density lipoprotein cholesterol (HDL-C).

There are complementary medical therapies to manage these symptoms and improve the quality of life while dealing with this life-altering situation.

Lipid-based drug delivery systems are advancing the frontiers in alleviating menopause-related systems. Here's a look at how this new technology works.

Lipid-based delivery formulations for managing menopause

Poorly water­soluble drugs pose a significant challenge in conventional pharmaceutical drug development due to their limited oral bioavailability and therapeutic effectiveness. Lipid­based formulations have emerged as a promising approach to improve the delivery of such drugs by overcoming these challenges.

Several studies have shown that lipid-based formulations significantly enhance drug solubility and dissolution rate compared to conventional formulations. Additionally, encapsulating lipid-based formulations shield the drug from degradation and enhance its stability. Integrating lipid-based formulations into capsules is a promising strategy for improving drug delivery and managing different disorders, ailments, and even bodily conditions like menopause.

Bilosome-based drug delivery

Progesterone, the natural female sex steroid hormone, is primarily involved in female reproductive functions. It plays a crucial role in preparing the endometrial layer of the uterus for the implantation of a fertilized ovum. The production of progesterone is known to decrease majorly during menopause.

External administration of progesterone offers several clinical benefits, including the management of secondary amenorrhea, dysfunctional vaginal or uterine bleeding, hormone replacement therapy, treatment of endometrial hyperplasia and contraception.

However, progesterone, classified as a BCS class II drug due to its high lipophilicity, encounters various obstacles with oral delivery. These hurdles include limited water solubility, low oral bioavailability, enzymatic degradation and hepatic first­pass metabolism. Enhancing the oral bioavailability of progesterone remains a critical concern for its long-term treatment.

Today, several innovative lipid vesicular systems are available that enhance the systemic bioavailability of progesterone. Bilosomes are one of them.

A bilosome is an innovative vesicular system integrating bile salts into the bilayer membrane composed of phosphatidylcholine and cholesterol. This combination with bile salts acts as a repellent to bile acids, enhancing the stability of bilosomes compared to liposomes within the gastrointestinal tract (GIT).

Moreover, the bilosome system exhibits ultradeformable properties, further enhancing its functionality.

This improvement is primarily attributed to the vesicles' enhanced permeability and reduced gastrointestinal tract (GIT) degradation. Thus, the novel bi-

losome system presents a promising solution to overcome the challenges associated with poor absorption and low oral bioavailability of progesterone.

Liposomal hyaluronic acid to manage vulvo-vaginal dryness

Another study evaluates the efficacy of a medical device containing liposomal hyaluronic acid on patients of different ages suffering from vulvovaginal dryness during menopause. Hyaluronic acid naturally occurs in the vulval and vaginal conjunctive tissue, offering hydrating and healing properties. It is commonly used to address menopause-induced vulvovaginal atrophy.

The study found that liposomal hyaluronic acid (HA) effectively alleviates symptoms and clinical signs of vulvovaginal dryness (VVD) across all age groups. It offers a safe and efficient alternative to topical and systemic hormonal therapy post-menopause.

Phospholipid liposomes to manage menopause-induced anxiety

In one clinical trial to assess the effectiveness and safety of phospholipid liposomes, a formulation was administered parenterally for managing anxiety and depression associated with menopause. The group treated with phospholipid liposomes exhibited significantly fewer symptoms such as anxious mood, tension and fear than the placebo group.

Government support is needed to accelerate advancements

Incorporating lipid-based formulations into menopausal management strategies is a practical and effective approach to improving women's quality of life during this transformative period. As research in this field continues to evolve, lipid­based delivery systems have the potential to revolutionize menopausal care, offering women tailored and holistic solutions for symptom relief and overall well-being.

To catalyze innovation in niche products like lipids-based formulations, the Government must support more research efforts in this field. Offering substantial backing to companies engaged in such research can accelerate advancements.

Regulatory sanctions, including favourable policies and incentives, can significantly encourage the adoption of lipid-based drug delivery systems to manage natural biological transitions like menopause.

VAV

Lipids Pvt. Ltd, India www.vav.in enquiry@vav.in

Preventing Oxidation in Omega-3 Softgels in One Simple Step

An innovative new gelatin increases softgel production efficiency and protects active ingredients at the same time.

Omega-3 fatty acids are well known for the vital roles they play in maintaining health and wellbeing. And as consumer awareness of their benefits continues to rise, so demand for omega-3 supplements maintains its upwards trajectory.1 However, for manufacturers, there are challenges in delivering products that remain stable and effective throughout their shelf life. Being highly susceptible to oxidation, omega-3s have to be handled with care.

Supplementary benefits

As vital components of the membranes that surround every cell in the human body, omega-3s are important for brain, heart, eye, joint and skin health, and more.

Of the three main types of these polyunsaturated fatty acids (PUFAs), alpha-linolenic acid (ALA) is mainly found in foods such as leafy green vegetables, soybean, nuts, chia and flaxseeds, as well as in plant oils and some animal fats. The body cannot produce ALA itself, so it must be obtained from foods or dietary supplements. The other two main types – eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) – are found in fish and other seafood. The body can convert ALA into EPA and DHA, but only in small amounts, so supplementation is a popular way of ensuring adequate supplies, especially for those who don’t eat fish.

The hazards of oxidation

Oxidation in omega-3 supplements reduces bioavailability and efficacy and hampers taste. Being able to make supplements that are not susceptible to oxidation is therefore a key goal – while also keeping in mind the need for efficient and cost­effective production.

Gelatin softgels are a popular delivery format because gelatin acts as a buffer, protecting omega­3s from oxidation. Despite this, traditional gelatin is not without its drawbacks here. After ingestion, it is prone to degradation, particularly in the acid environment of the stomach. As the softgel degrades, the fill becomes vulnerable to oxidation, and studies show that oxidative stress during the gastric phase has a profound negative effect on omega­3s, significantly decreasing their bioaccessibility. 2

Enteric softgels are one way of protecting PUFAs at this critical stage of digestion, yet they have drawbacks too. Production usually involves two steps: initial manufacture and subsequent coating –often at a third-party site. This means longer processing times, additional production costs and transportation issues including environmental emissions and extra expense. The enteric coating also results in opaque capsules with reduced consumer acceptance.

A new era of enteric capsules

With DELASOL®, these issues are consigned to the past. DELASOL® has in-built enteric capabilities, so softgels do not have to be coated in a second step. This not only saves time, money and resources, but also leads to brilliantly clear softgels with premium appeal. Because the contents are protected, there is no need to overfill, so capsules are smaller, easier for consumers to take and less expensive to fill.

The DELASOL® secret lies in its advanced blend of gelatin and another natural hydrocolloid, pectin. Whereas typical enteric coatings use synthetic, oilbased polymers from non-sustainable sources, DELASOL® is 100 percent natural. It allows a lower carbon footprint than traditional enteric capsules, works on existing softgel equipment and does not require major changes to standard production parameters. This makes it a great choice for smarter enteric softgels – from environmental, manufacturing and consumer points of view.

DELASOL® overcomes oxidation challenges

With their proven ability to pass through the stomach intact, DELASOL® softgels safeguard the bioavailability of their contents until they reach the small intestine.

DELASOL® exhibits excellent barrier properties against oxygen diffusion through the capsule shell. Oxygen transmission tests in accordance with ASTM D 3985­02 have shown that films produced with a recommended DELASOL® formulation have excellent oxygen barrier properties (23 °C, 50% rh). Very low oxygen permeation is particularly important when the product must be protected from oxidation throughout its shelf-life. 3

pH-dependent release

With a dissociation pH value of approximately 6.5, DELASOL® softgels survive the acidic environment of the stomach and only begin to dissolve and release their fill once they reach the neutral pH of the small intestine. In the highly acid environment of the stomach, the smart combination of pectin and gelatin in DELASOL® forms a virtually insoluble network. However, when the environment becomes more pH-neutral, as is the case in the small intestine, the pectin and gelatin polymer chains, with their natural charge, form a soluble complex that attracts water and starts to dissolve.

Performance tests

The revolutionary performance of DELASOL® has already been proven in successful nutraceutical products on the open market, as well as in a series of in-vitro studies conducted by the GELITA Pharma Institute in line with US and European Pharmacopeia (USP and Ph. Eur.).

Disintegration: USP <701> and Ph. Eur. 2.9.1

To test DELASOL® softgel disintegration, baskets containing the capsules were moved up and down for up to two hours in simulated gastric acid fluid (37°C, pH 1.2). After two hours, the environment was

FIGURE 1 After 120 minutes, fresh and 6-monthold softgels containing DELASOL® remain intact, but dissolve within five minutes after pH adjustment to neutral.

changed to simulated intestinal fluid (37 °C, pH 6.8).

The results showed that there was no disintegration or rupturing of the capsules in the gastric acid­type fluid. However, all of the capsules disintegrated in the simulated intestinal fluid much quicker than the 45 minutes required by the USP.

Dissolution: USP <711> and Ph. Eur. 2.9.3

To further test the dissolution properties of DELASOL®, capsules were immersed in two different environment phases: simulated gastric acid fluid (37°C, pH 1.2) followed by simulated intestinal fluid (37°C, pH 6.8) in glass vessels with moving paddles.

Not only did the DELASOL® capsules remain intact after one hour (USP) and two hours (Ph. Eur.) in the gastric acid-type solution, but fast and complete dissolution was obtained within 45 minutes – as required by the USP – in the simulated intestinal fluid.

Stability

To examine the effect of storage on the stability and performance of oil­filled, standard die rolled softgel capsules, fresh and six-month-old DELASOL® capsules were compared with fresh and six-monthold standard bovine gelatin capsules.

Results show that the standard bovine capsules dissolved rapidly in the acid environment (<30 minutes). After 120 minutes, the DELASOL® capsules were about half of their original thickness, but the capsules remained 100 percent intact and no fill was released. The remainder of the DELASOL® shell dissolved very quickly and the fill was released in less than five minutes when the solution was adjusted to a neutral ph. Importantly, there was little difference between the fresh and six-month-old DELASOL® capsules, demonstrating the stability of DELASOL® over time.

References:

1 www.marketsandmarkets.com/ResearchInsight/size-and-shareof-omega-3-market.asp [last accessed: 22/10/24].

2 S. Floros, et al., (2022) Bioaccessibility and Oxidative Stability of Omega-3 Fatty Acids in Supplements, Sardines and Enriched Eggs Studied Using a Static In Vitro Gastrointestinal Model. Molecules 27, 415 https://www.mdpi.com/1420-3049/27/2/415.

3 Internal GELITA Report Fraunhofer IAP, July 2024.

Enteric softgels with DELASOL® can protect omega-3 oils from oxidation.

Liposomal Formulation Promising for Managing Osteoarthritis-induced Pain

Osteoarthritis is a chronic condition characterized by the breakdown of cartilage in the joints, leading to pain, swelling, and reduced mobility, with increasing prevalence due to aging and obesity. Liposomal formulations, particularly liposomal hyaluronic acid, show promise in improving drug delivery and providing effective pain relief for osteoarthritis, though further research is needed to optimize treatment strategies.

AUTHOR: Arun Kedia, Managing Director, VAV Lipids

Osteoarthritis (OA), one of the most common forms of arthritis, is a chronic condition marked by the gradual breakdown of cartilage in the joints, causing pain and physical limitations. It involves various changes, such as the degradation of the cartilage and its mechanical properties, as well as the development of fissures. At the same time, it increases bone turnover, resulting in thickening of the bone around the joints. Osteophytes are also formed on the joint edges, indicating abnormal bone remodelling.

The signs of osteoarthritis include pain, swelling, reduced mobility and joint deformity. In severe cases, it can lead to muscle loss, decreased proprioception and even disability. Studies say that, by 2050, 130 million people worldwide will have osteoarthritis, with 40 million experiencing severe disability due to the condition. The prevalence of osteoarthritis is rising due to factors like an ageing population and increasing obesity rates.

Therapy for osteoarthritis

Despite extensive research on osteoarthritis, its complex pathophysiology has yet to be understood completely. As of now, there is no universally accepted treatment standard. Currently, a "step therapy" approach is commonly employed, and it involves non-pharmacological, pharmacological, and surgical treatments aimed at alleviating pain symptoms and restoring joint function.

Pharmacological treatments are often used in the early stages of osteoarthritis to manage symptoms effectively and are widely practised in clinical settings. One such treatment methodology for osteoarthritis is using Hyaluronic Acid supplements. Hyaluronic Acid (HA) is a gel-like substance that naturally occurs in the human body.

It aids in joint cartilage and bone growth and development. Hyaluronic Acid reduces joint inflammation and pain resulting from injury or tissue degeneration. This is why intra-articular Hyaluronic Acid injection has emerged as an effective therapy for

osteoarthritis pain relief. Hyaluronic Acid also exhibits excellent gelling properties due to its strong water-binding capacity.

However, some cases have shown a lack of effectiveness of the Hyaluronic Acid injection treatment, possibly due to its brief retention duration in the joint cavity. This often requires repeated intra-articular injections to showcase its therapeutic benefits. Apart from its brief retention post-injection, another factor contributing to the perceived inefficacy of Hyaluronic Acid injection into the synovial joint is its failure to localize to the joint surface when administered. Studies have shown that while Hyaluronic Acid supplementation improves the viscoelasticity of synovial fluid, it does not achieve lubrication of the cartilage surface unless localized there. However, emerging technologies like encapsulation in liposomes are overcoming these barriers.

Role of liposomes as effective drug carriers

In general, liposomal nanoparticles have been known to enhance the effectiveness of many formulations and have been in clinical use for years. They have also been thoroughly explored as drug carriers for treating Rheumatoid Arthritis, another type of arthritis. However, many drugs used for rheumatoid arthritis treatment suffer from low bioavailability, rapid clearance and lack of selectivity, which means they need frequent, high dosing for effective therapy. Unfortunately, these high doses also raise the likelihood of systemic side effects.

Using liposomes as drug carriers enhances the therapeutic potential of these antirheumatic drugs. By adjusting liposomal properties, such as size and surface charge, it is possible to optimize their ability to penetrate biological barriers. This also increases the likelihood of them remaining at the administration site, reducing premature degradation and toxicity to unintended tissues.

The ideal properties of liposomes vary depending on the administration route. Larger liposomes are

adequate for local injection, while smaller ones are better for passive targeting. Moreover, liposomal surfaces can also be tailored for selective drug delivery to specific cells in arthritis.

Why liposomal hyaluronic acid can be an effective treatment arthritis

Hyaluronic Acid hydrogel can be combined with additional molecules and particles that function as lubricants. Liposomes, for instance, are a class of molecules known to decrease the friction typical of biological surfaces through boundary lubrication. Researchers have investigated the combined lubricating effects of liposomes with hyaluronic acid hydrogel as a possible treatment approach for joints affected by arthritis.

This approach involves encapsulated liposomes offering improved boundary lubrication to Hyaluronic Acid hydrogel by creating a hydration shell on the gel surface. This shell prevents water molecule loss from the gel bulk. Research has shown this synergistic effect of Hyaluronic Acid hydrogel­mediated liposome delivery using a tendon explant model. In this model, the combined delivery method significantly decreased the tissue surface friction coefficient compared to delivering Hyaluronic Acid or liposomes alone.

In another research, a combination of Hyaluronic Acid and liposomal nanoparticles was developed and evaluated as a potential treatment for osteoarthritis inflammation and pain relief. The optimal liposomal nanoparticle maintained stability, efficient drug delivery and encapsulation without losing efficacy until reaching the target organ.

Key takeaways

Studies and research into the efficacy of liposomal formulation for reducing inflammation show promise for managing osteoarthritis-induced pain. Similar strategies have shown beneficial effects in rheumatoid arthritis therapy.

Administering biodegradable liposomal Hyaluronic Acid-based analgesics directly into the joint cavity has emerged as a viable option. These formulations aim to minimize adverse reactions while providing effective pain relief.

However, several challenges remain in translating this treatment to human clinical use. Determining the optimal dose, frequency and timing of treatment based on disease severity and location is crucial. This calls for further research to advance the application of this treatment approach in the future. More government- and academia-based research could be a way to enhance the uptake of such treatments.

Research on Dementia Prevention in Women

Probi announces a research collaboration with the Global BHP BrainTrust and FINGERS Brain Health Institute (FBHI) aimed at reducing dementia risk in women.

"We are thrilled to be part of the FINGERS Plus for Women initiative. This collaboration represents a significant step forward in our commitment to advancing brain health and improving everyday life for people worldwide. By combining our expertise in probiotics with the innovative research approach of the Global BHP BrainTrust and the Fingers Brain Health Institute, we aim to make a significant impact on cognitive health and well-being," says Anita Johansen, CEO of Probi AB.

Probi AB, a global leader in probiotics, and the Global BHP BrainTrust, a renowned advisor and research organization specializing in brain health, are excited to announce the intention to collaborate on the FINGERS Plus for Women initiative together with the Fingers Brain Health Institute (FBHI) founded in 2019 by Professors Miia Kivipelto and Maris Hartmani. FBHI drives, coordinates, and supports the continued clinical research that builds on the original FINGER study1, which showed that lifestyle factors have significant relevance in the prevention of cognitive decline.

The goal is to advance and expand the multi-domain FINGER model for preventive lifestyle interventions, exploring new modifiable risk and protective factors such as stress, sleep, education, music, diet, and the microbiome. Thus, providing deeper insights into how microbiome intervention, e.g. changes in the body’s ecosystem of microorganisms, along with other protective factors, can collectively influence cognitive function and mental well­being in women.

The initiative is driven by the growing recognition of the critical role that lifestyle factors and the microbiome play in brain health. According to the latest evidence 45 percent of all dementias are likely linked to modifiable risk factors creating great potential for prevention2. This research has the potential to deliver transformative impact, including the development of targeted interventions to enhance brain health and prevent cognitive decline. The findings will contribute to a broader understanding of personalized health strategies, ultimately improving the quality of life for women worldwide.

For more information about Global BHP BrainTrust visit: www.globalbhptrust.com

References:

1 Ngandu, Kivipelto, et al., The Lancet, Volume 385, Issue 9984, 2255 – 226 (2015)

2 Livingston et al., The Lancet, Volume 404, Issue 10452, 572 – 628 (2024)

Capsule Evolution: Fine Foods Shaping the Future of Health and Wellness

The European food supplement market is witnessing innovations in capsules as the most popular form, with the company Fine Foods developing advanced capsule technologies that enable more efficient, aesthetically appealing, and stable products with improved active ingredient release profiles.

The European food supplement market is experiencing a wave of innovation, with capsules continuing to dominate as the preferred delivery method. According to Mintel, capsules accounted for 37 per cent of product launches across Europe last year. This trend highlights consumers' growing demand for convenient and effective methods to improve their health and well-being.

Fine Foods & Pharmaceuticals N.T.M. S.p.A., an Italian independent Contract Development & Manufacturing Organisation (CDMO) that develops and manufactures products for the pharmaceutical, nutraceutical, and cosmetics industries, is at the forefront of this transformation. The company is pioneering innovative capsule technologies that address long-standing industry challenges, providing numerous advantages for manufacturers and consumers.

last October, one of the world’s leading exhibitions for pharma and nutraceutical ingredients.

While traditional capsules have long been valued for their recognisability, sleek design, ease of swallowing, and versatility with various active ingredients, they do exhibit certain limitations in specific cases. Fine Foods' latest innovation addresses these challenges head­on, while still preserving the benefits of conventional capsules. Key advantages include:

• Enabling the development of innovative formulations previously difficult to achieve By overcoming the technological and physical limitations of different ingredients ­ such as powders, crystals, pellets, or oils - this advancement opens the door to new solutions and unique combinations of active compounds. This enhances product appeal and boosts consumer satisfaction. It expands the range of formulation possibilities, allowing for

products tailored to individual consumer preferences and needs.

• Minimising the use of additives/excipients and addressing technological challenges

By reducing reliance on additives and excipients, the concentration of active ingredients in the final product can be increased, aligning with the growing consumer demand for clean-label supplements. This approach aligns with modern consumers, particularly younger generations and seniors, who seek "all-in-one" solutions to simplify their daily supplement routines.

• Formulations with modified release profiles

Overcoming the challenges of producing modified release formulations in capsules allows for greater product differentiation in the market by combining fast-acting and sustained-release ingredients, with the added option of gastro-resistant properties when necessary. Sustained-release formulations, designed to release active ingredients gradually over time, provide many benefits, including improved nutrient absorption, reduced side effects, and the convenience of fewer daily doses. Gastro-resistant capsules engineered to withstand stomach acidity, release their contents directly into the intestines, protecting the stomach lining from irritants and preventing premature degradation of active ingredients. This targeted delivery system enhances product efficacy while minimising unwanted side effects.

• Resolving stability challenges

By addressing stability issues caused by interactions between active ingredients, excipients, and the capsule shell, the risk of ingredient degradation is significantly reduced. This ensures the product remains stable and effective throughout its shelf life.

• Enhancing product aesthetics

Combining various active ingredients allows for the creation of visually striking, multi-coloured capsules that increase the product’s aesthetic appeal. This visual distinction strengthens brand identity and fosters deeper engagement with consumers.

These advancements in capsule technology represent a major breakthrough for the nutraceutical industry. Fine Foods' commitment to innovation and excellence places it at the forefront of contract development and manufacturing. By pushing the boundaries of capsule technology, Fine Foods is paving the way for a future where health and wellness solutions are more accessible, effective, and tailored to individual needs.

First Fermented Salidroside with Clinical Support for Sports Nutrition in the U.S.

Landkind® Pure Salidroside is suitable for capsules, tablets, powders, and more.

Rhodiola (rosea or crenulata), well-known for its impact on performance energy levels, has been a botanical used in natural products for centuries, with salidroside, Rhodiola’s most studied bioactive, playing an essential role in its efficacy. Due to its increasing demand, Rhodiola species are threatened by overharvesting. They were added to the Convention on International Trade in Endangered Species (CITES) list of Wild Fauna and Flora to ensure sustainable harvest and trade. Landkind® Pure Salidroside is crafted through an innovative fermentation process that bypasses the need to harvest the endangered Rhodiola species. Through the fermentation process, Landkind®Pure Salidroside offers a sustainable source of Rhodiola with consistent purity, all while being inherently CITES compliant.

“We are incredibly proud to add Gnosis’s sustainable, ethical, and clinically backed rhodiola bioactive to our sports nutrition portfolio,” said R.V. Venkatesh, Co­Founder and Managing Director at Gencor. “We are passionate about providing groundbreaking ingredients with human clinical data to meet and exceed the needs of today’s and tomorrow’s consumers.”

Landkind® Pure Salidroside is the first and only ingredient in a recent clinical study that demonstrated its effectiveness in enhancing oxygen uptake during exercise at 60 mg/day.

“We selected Gencor as our partner because of their expertise, longevity, and honorable reputation in the industry,” said Nicole Lemus, Gnosis by Lesaffre Director Americas. “At Gnosis, we believe that promoting well­being is as important as preserving our environment, a principle that begins with our production techniques. We are deeply passionate about preserving this botanical species and understand its great potential for human health. Through fermentation, we’ve ethically developed the most studied and main bioactive, salidroside, in a convenient, consistent nutraceutical for sports and active nutrition.”

Landkind® Pure Salidroside is suitable for capsules, tablets, powders, and more. It is Halal­certified, vegan, and gluten­free.

Via Berlino, 39

24040 Zingonia/Verdellino – Bergamo – Italy

www.finefoods.it

info@finefoods.it

Fine Foods & Pharmaceuticals N.T.M. S.p.A.

Fi Europe Gears Up For Its Best Edition Yet

The unmissable ingredients show returns to Frankfurt with additional features.

Fi Europe is gearing up for its biggest and best year ever. From 19-21 November 2024, Messe Frankfurt will host the leading global event for food and beverage ingredients. More than 1,500 exhibitors and a programme of expert presentations will showcase innovation, share insights and foster business relationships. Over 25,000 visitors from 135 countries are expected to attend and exhibitors will include ABF Ingredients Group, Azelis, Brenntag Holding GmbH, Cargill, Fonterra and Prinova.

The main show arena will feature exhibitors from across the full F&B ingredients spectrum including, for the first time ever, a Petfood Suppliers Hub where visitors can explore the latest ingredients and technologies for pet nutrition. The health ingredients area is dedicated to functional F&B ingredients with proven health benefits. And the expanded Food Manufacturing Technologies & Solutions Area is a one-stop destination for those seeking practical and innovative ways to optimise their supply chain and future-proof their operations, from R&D to delivery.

Fi Europe has a strong track record of facilitating business partnerships that deliver successful products. As well as comprehensive exhibition halls offering an opportunity to meet with the best in the business, Exhibitor Showcases will allow innovators to share their unique ideas. All visitor passes also include free access to the Innovation Hub, which will run throughout the show, with a bustling programme

of presentations and discussions covering a range of opportunities. Free access to the two-day Fi Europe Conference (19-20 November) is included with all visitor passes too. During a rich variety of expert-led sessions, speakers will focus on solutions for current industry challenges and immediate opportunities for R&D and product development.

Yannick Verry, Brand Director, Food ingredients Europe & Americas, says: “We’re excited to be back in Frankfurt for Fi Europe 2024. The event has been growing and evolving with the needs of the F&B ingredients industry and we’re constantly looking for new ways to offer a bigger and better platform for our exhibitors and visitors to connect. This year we have some great additions alongside our tried and trusted favourites that make the event even more unmissable than before.”

Exclusive insights will once again be shared at The Future of Nutrition Summit. This special event takes place at the Mövenpick Hotel Frankfurt City on 18 November, the day before Fi Europe opens its doors. Attendees can access the summit with a delegate pass and will hear from industry leaders and visionaries who will give presentations and lead discussions on future trends and developments in health and nutrition. Topics will include Food As Medicine, AI and Food and Sustainable Solutions.

In fact, sustainability will be a key thread running throughout Fi Europe 2024. “Our partnership with international civil society organisation Solidaridad is part of our ongoing commitment to sustainability,” says Yannick Verry. “Throughout our Fi Europe features and content, we will highlight sustainable sourcing, transparency, regulatory compliance and more.”

With data-driven matchmaking and The Women’s Networking Breakfast also back this year, Fi Europe offers unrivalled networking opportunities. To help attendees plan their days, book meetings and optimise their time, the user-friendly Fi Europe event platform is available online now.

“Visitors and exhibitors can log into the event platform at any time,” says Yannick Verry. “They can browse products and suppliers and use our AI-driven matchmaking tool to connect with potential business partners. We’ve designed it to make planning easier for everyone before the event and we can’t wait for our F&B community to experience Fi Europe in person.”

For more information and to register your attendance, visit the Fi Europe website at: https://www.figlobal.com/europe/en/home.html

SupplySide West Ignites Health and Wellness Industry with 19,000 Registered Participants at Global Showcase

The largest global event driving health and nutrition innovation and sourcing increases attendance by 11%.

SupplySide West and Food ingredients North America, presented by Title Sponsor KSM-66

Ashwagandha, the foremost showcase for the health and nutrition industries, convenes 19,000 registered attendees and more than 1,500 exhibitors from over 80 countries from around the world to explore the forefront of innovative ingredients and solutions entering the market.

Connecting buyers and suppliers from throughout the dietary supplement, food, beverage, personal care, pet and sports nutrition sectors, SupplySide West provides the ultimate platform to discover advanced ingredients and technologies, engage with prominent movers and shakers and gain insights into the trends shaping the future of the industry.

"As health and nutrition expands and consumers of all types grow increasingly conscious of their wellbeing, SupplySide West, now reimagined as SupplySide Global, remains the catalyst for the concept and creation of the next best products and trends, brought to life through an immersive experience that brings significant value to attendees from start to finish," says Danica Cullins, Executive Vice President of Health and Nutrition at Informa Markets. "New show features and curated spaces including education sessions, lunch briefings and special features in a variety of booths engage attendees to leverage opportunities to connect with brands, manufacturers and other industry professionals on and off the expo floor, fostering an impactful environment where connections are made, and innovation is inspired."

Trade experts and thought leaders presented more than 135 hours of education and insights addressing the future of the health and nutrition landscape and reflecting on the rapid changes across the industry. Most notably, education sessions discussed women's health, biotic and microbiome commercial markets and functional ingredients, while executives from Olly, NSF International and Nuherbs Co., Nutrition Business Journal and SupplySide Journals explored supplement development.

"The caliber of education throughout the event continues to be exceptional, with a focus on timely and relevant topics, trends, regulations and solutions that span a multitude of topics," shares Sandy Almendarez, Vice President of Content at SupplySide. "Sessions highlighting food and beverage sci-

ence, regulatory compliance, supplement supply chain and formulation provide opportunities to connect and learn from the industry's most established voices who are actively creating, testing and regulating the products that consumers know and trust."

This year's event introduced enhancements, elevating the attendee experience and strengthening industry engagement. The New Product Zone spotlighted the latest product developments, drawing attention to emerging trends and innovative solutions such as plant-based supplements and diverse usage of probiotics, while the Sustainable Packaging Zone highlighted 14 unique solutions in material advancements and eco-friendly package design, underscoring the industry's commitment to environmental responsibility. The event welcomed several companies to the New Exhibitor Zone including Arm & Hammer, Nexus Laboratori s.r.l. and Premium Goods.

The SupplySide Networking Hub facilitated connections, providing a dynamic space for professionals to meet and converse. Adding to the vibrant atmosphere, the Diwali celebration brought together attendees in observance of the Festival of Lights, alongside other activations including the Expo Hall Putt Putt, Zen Den and Bark Park with adoptable puppies offering mindful moments to engage, connect and recharge.

The newly reimagined event SupplySide Connect New Jersey returns to Meadowlands Exhibition Center April 8-9, 2025, and SupplySide Global will return to the Mandalay Bay Convention Center in Las Vegas October 27-30, 2025.

Euromed

At SupplySide West 2024, Euromed showcased its extended range of Mediterranean fruit and vegetable extracts aimed at supporting healthy aging and wellbeing. Euromed also unveiled results from groundbreaking clinical trials highlighting the diverse benefits of its botanical extracts for skin health, cardiovascular function, immunity, joint and muscle health, and the microbiome. One notable example, perFix™, a new extract from persimmon, demonstrated significant weight management benefits, potentially interfering naturally with fat absorption.

perFix™, the latest ingredient in Euromed’s line of premium Mediterranean fruit and vegetable extracts, was the focus of a recent clinical trial suggesting its potential for promoting healthy body composition and targeting areas such as abdominal fat, showing promise for weight management supplements. The company’s pomegranate extract, Pomanox®, also featured prominently at the event, with over 15 years of R&D backing it and multiple studies relating to beauty from within, healthy aging, and weight management. Additionally, Euromed presented its Earth Harmony Organic Extracts®, certified organic botanicals reflecting the company’s commitment to quality and sustainability.

Andrea Zangara, Head of Scientific Marketing and Medical Affairs at Euromed, commented, “As the global nutraceutical market grows, our products offer proven efficacy backed by robust research, meeting demand for reliable, health-supporting botanicals. Our branded ingredients are backed by sound scientific evidence that demonstrates not only their efficacy but also the proprietary nature of our extraction methods and compositions. We were particularly proud to present our new product perFix™ to the SupplySide West audience and highlight its promising potential for weight management applications.”

https://euromedgroup.com/

GC Rieber VivoMega

GC Rieber VivoMega debuted its new algal EPA + DHA omega-3 concentrate at SupplySide West for the first time.

The EPA and DHA combination is Vegan certified and non-GMO with superior triglyceride content (90%), bioavailability, purity, and sensory profiles. Its SuperLight™ proprietary processing technology is designed exclusively for algal oil, allowing for gentle, non-invasive processing with superior oxidation

protection. This results in a product with exceptional quality parameters and optimal resource utilization with little to zero waste.

VivoMega™ Algae Oils also exceed all recognized quality standards of GOED and IFOS 5 Star on oxidation and environmental parameters. In addition, VivoMega™ Algae Oils fully aligns with the EU Green Deal initiatives and the UN Global Compact guidelines.

Visit www.VivoMega.com to learn more about the company’s commitment to the industry through sustainable and traceable initiatives and innovative technologies that enable it to provide world-class oxidation parameters.

https://vivomega.com/

Gencor

Gencor featured the newest addition to its arsenal of sports nutrition ingredients by Gnosis, LANDKIND® Pure Salidroside. Rhodiola(rosea or crenulata) is well-known for its impact on performance energy levels. It has been a botanical used in natural products for centuries, with salidroside, Rhodiola’s most studied bioactive, playing an essential role in its efficacy. Due to its increasing demand, Rhodiola species are threatened by overharvesting. They were added to the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) list to ensure sustainable harvest and trade.

LANDKIND® is crafted through an innovative fermentation process that bypasses the need to harvest the endangered Rhodiola species. Through the fermentation process, LANDKIND® Pure Salidroside offers a sustainable source of Rhodiola with consistent purity, all while being inherently CITES compliant. LANDKIND® is the first and only ingredient, and a clinical study demonstrating its effectiveness in enhancing oxygen uptake during exercise at 60mg/day.

The company will also unveil its soon-to-be-published clinical data on Levagen®+ for women’s health and host a sports nutrition giveaway.

Contact us to inquire about our sports nutrition portfolio, and we’ll send you a prize! Visit https:// www.gencorpacific.com/ to learn more about our latest clinical studies for men’s and women’s health.

https://www.gencorpacific.com/

Gelita

GELITA, a pioneer in collagen science and associated applications, was once again proud to sponsor the Collagen Category at SupplySide West this year. In its third consecutive year as a sponsor, GELITA hosted educational sessions on active nutrition and supplement delivery systems, updating audiences on the latest regulatory, scientific, and market landscapes and exploring the impact of technology and demographics.

Attendees had the chance to explore GELITA’s innovations, including Bioactive Collagen Peptides (BCP®) with scientifically proven benefits for beauty from within, sports nutrition, and healthy aging. GELITA also showcased its newly rebranded softgel specialty portfolio of gelatins, featuring timed fill release for fast (RAPISOL®) and delayed release (DELASOL®), enhanced stability (RXL® range), and leak reduction (EASYSEAL®).

“We were delighted to be the official Collagen Category sponsor at SupplySide West again this year,” said Jessica Pföhler, Global Marketing at GELITA. “Engaging with customers face-to-face was invaluable, as we enjoy the challenge of discussions on how our products can meet the most demanding development needs.”

http://www.GELITA.com

Kemin

Kemin Human Nutrition and Health showcased its portfolio of functional ingredients that deliver a wide range of science-backed health solutions. Covering everything from the role of Kemin ingredients in digestive aging™ and digestive stress™, to their use in the expanding field of women’s health and their impact on children’s health, Kemin offered proven solutions ideal for various dietary nutrition products, including functional beverages, food, and supplements.

“The Kemin team was excited to be a part of this year’s SupplySide West show,” said Josh Swalla, Global Marketing Director, Kemin Human Nutrition and Health. “We looked forward to meeting with attendees at the show, where we highlighted recent developments and demonstrated how our science-backed solutions can inspire brands to create a new generation of health and wellness products to support healthier lives.”

Kemin highlighted its health-forward ingredients, including:

• FloraGLO and OPTISHARP – Kemin offered a portfolio of superior, sustainable carotenoid solutions, with FloraGLO at its core, proven in numer-

ous studies to support vision, cognition, and skin health.

Kemin experts were available to discuss the recent L-ZIP clinical trial, funded by the National Institutes of Health’s prestigious National Eye Institute, which showed that supplementing pregnant mothers with both FloraGLO and OPTISHARP improved carotenoid status in both mothers and babies and demonstrated improvement in infants’ eye development. This provided compelling evidence that lutein and zeaxanthin should be considered essential care for pregnant mothers.

Additionally, Kemin shared new topline results from the first clinical trial studying FloraGLO in healthy pre-teens and teenagers consuming a Western diet. The recent LuTEEN trial demonstrated efficacy in both the eye and brain with only five milligrams of FloraGLO in a commercial sugar-free gummy.

• ButiShield™ – An encapsulated form of calcium butyrate, which provides controlled release of butyric acid to support gut health, digestive aging, and digestive stress.

SSW visitors were able to learn more about the power of digestive adaptogens and how they may help build resilience to stressors that affect the digestive system. Kemin assisted customers in determining the optimal dosage of butyric acid based on the fiber gap of their products.

• BetaVia™ – This algae-sourced, postbiotic beta-glucan helps prime key immune cells, shapes the microbiome, and protects intestinal barrier integrity to support digestive aging and digestive stress.

• DailyZz™ – Kemin’s natural, proprietary botanical blend, rich in polyphenols, is clinically shown to promote post­sleep brain benefits, including improved mental speed and focus, decision making, and visual recall.

https://www.kemin.com

Probi

Probi launched a clinically-supported probiotic solution for metabolic health at SupplySide West 2024.

With 88 percent of U.S. adults being metabolically unhealthy and over 1.9 billion adults classified as overweight worldwide, the need for effective metabolic health solutions was acute. To address one of the most critical health issues of our time, Probi unveiled a new product concept.

Metabolic health, cardiovascular support, and weight management were key areas addressed by Metabolic Health by Probi®, the latest innovation from Probi, showcased at SupplySide West 2024 during October 28–31.

“Our aim is to help people take control of their microbiome, their gut, and live better for longer. With this product, we specifically want to support meta-

bolic well-being. With cardiovascular disease and type 2 diabetes being the top two causes of death globally, the need couldn’t be more urgent,” said Anita Johansen, CEO of Probi.

Metabolic Health by Probi® is a new probiotic concept that targets the key markers of metabolic syndrome, a condition linked to higher risks of cardiovascular disease and diabetes. By combining two proprietary probiotic strains, Lactiplantibacillus plantarum 299v (LP299V®) and Lacticaseibacillusparacasei 8700:2 (L. Paracasei 8700:2®), this new solution provided scientifically backed support for cardiovascular health, weight management, and blood pressure regulation while promoting overall gut function.

Backed by robust clinical evidence, Metabolic Health by Probi® is poised to make a significant impact on the global dietary supplement market by offering brands a flexible solution to meet their consumers’ demands.

https://www.probi.com/

TriNutra®

At SupplySide West, TriNutra® shared the published data on the potential of ThymoQuin®, its patented, UPS-grade, extra virgin black seed oil to support healthy cortisol levels.

Consumer interest in managing cortisol levels is on the rise, especially with the aid of dietary supplements. The search for cortisol-lowering supplements on Google surged by 250% in 2024, and the search term ‘what supplements lower cortisol’ saw a 200% increase. Consumers are increasingly aware of the impact of cortisol levels on various aspects of health, such as mood, stress, immune function, glucose levels, inflammation, and weight management.

TriNutra’s published clinical trials demonstrate ThymoQuin’s ability to reduce cortisol levels. A human clinical study found that 500mg/day of ThymoQuin® led to a significant decrease in cortisol levels over four weeks. Volunteers experienced a 44% reduction in cortisol levels, reported a more positive mood (+11%), and a 62% decrease in Upper Respiratory Tract Complaints, indicating improved resilience and well-being, compared to the placebo. This study was further supported by two additional human clinical studies, which showed that ThymoQuin®, when combined with Astaxanthin or Omega-3s, produced even better results in managing cortisol levels.

This research underscores the remarkable impact ThymoQuin can have on supporting healthy cortisol levels, a crucial need that consumers are actively seeking.

TriNutra also highlighted the approval of six structure-function claims from Health Canada, which allows finished product manufacturers to make specific recommendations based on the published scientific data as an oral supplement. The following approved claims are:

1. Help support healthy liver function*

2. Help support cardiovascular health*

3. Help support healthy glucose levels*

4. Help support stress relief*

5. Help moderate general feelings of stress*

6. Help support healthy gut microbiota*

Visit Trinutra.com to learn more about ThymoQuin’s clinical research and its applications for beauty, hair, and scalp (B’utyQuin®), and oral health (ThymoQuin-OCare®), or email service@trinutra.com to request a free sample.

www.trinutra.com

Unibar Corporation

Latest Dry Eye Science

According to the American Academy of Ophthalmology, over 340 million people worldwide have dry eye disease (DED)1. Its occurrence varies widely around the world, ranging from 5 to 34% prevalence depending on the region2. DED is often used as an umbrella term referencing reduced quality or quantity of tears due to complex ocular surface inflammatory disease3. Symptoms include burning, itching, blurred vision, light sensitivity, and visual strain3,4. Factors such as age, gender, contacts, dust, and screen time can exacerbate the symptoms3. Poor diet lacking antioxidants and vitamins is often an overlooked cause4

On a mission to help improve eye health globally, Unibar Corporation featured the latest dry eye science behind its award-winning eye health ingredient, CapsiClear®, at SupplySide West. A recent seven-week published study showed that oral supplementation of CapsiClear Capsanthin resulted in a statistically significant:

Decrease in corneal inflammation2

Increase in tear break-up time2

• Alleviation of dry eye symptoms2

CapsiClear Capsanthin supplementation also increased serum antioxidant levels and inhibited the expression of inflammatory cytokines, such as TNF-α, IL­2, IL­4, IL­6, and pro­inflammatory mediators2

Farm to Finish Lutein Sustainability Initiative

Wildfires, extreme weather, and other climate changes catapulted sustainability discussions to the forefront for many brands at the tradeshow this year.

As climate change intensifies pressure on water resources and negatively impacts soil fertility, crop yields, and the nutrient composition of extracted ingredients, the natural products community will need to identify and implement unique sustainability solutions.

As a leading supplier of premium-quality, clinically studied eye health ingredients, Unibar also high-

lighted and shared its unique Farm to Finish sustainability efforts for UniGold™, a GRAS­affirmed lutein extract for eye health, at SupplySide West.

Native to Africa, South America, and Asia, marigolds (the key source of lutein) have a rich cultural significance dating back to the 16th century. Recognizing their scientifically validated benefits for eye, skin, and brain health, Unibar and its partners use sustainable, regenerative farming practices to harvest marigolds in regions local to marigold flowersIndia and Africa.

From using high-quality seeds to nurturing the soil without the use of chemical insecticides, Unibar is committed to prioritizing improved soil health, reducing water usage, paying fair wages to farmers, and reducing its carbon footprint when cultivating marigolds for its proprietary Lutein extract, UniGold.

Unibar also offers free lutein, lutein esters, zeaxanthin, and meso-zeaxanthin. Unibar’s complete portfolio of lutein and zeaxanthin ingredients is backed by Farm to Finish sustainability.

Anti-aging Eye Serum with Bellaneo

Stress, anxiety, and lack of quality sleep continue to dominate as some of the leading health conditions among consumers. The cumulative effect of these conditions can have a significant impact on aging and skin health. In fact, there is a rise in TikTok video views and Google searches around the topic of “undereye creases,” making eye health serums one of the fastest-growing subsegments of skincare5

For health and wellness brands looking to enter this market or supercharge their growth, Unibar launched Bellaneo, a clinically studied capsanthin extract for skin health. This extract has been shown to support skin elasticity, provide antioxidant protection, and hydrate the skin6. Unibar showcased its latest innovation, Bellaneo, in the form of an anti-aging eye serum and gave away samples to SupplySide West attendees.

To learn more and request data sheets on CapsiClear®, UniGold™, and Bellaneo, contact Unibar at contact@unibarcorp.com or visit https://unibarcorp. com/.

References available upon request https://unibarcorp.com/

ing the brain send messages to the muscles, and contributes to the production and maintenance of nitric oxide, which assists in improving blood flow. Choline is considered an essential nutrient for liver health, aiding in the transport of lipids out of the liver. Additionally, it improves visuomotor performance, optimizing reaction time and nervous system function.

The patent-pending transparent liquid capsule solution, developed by Vantage Nutrition in Chadds Ford, PA, allowed brands to offer a unique, visually appealing dose form, which is clean label and ranges from 275 mg to 550 mg of free choline in a single capsule serving.

The VitaCholine® liquid capsules underwent stability testing under Zone IVb conditions, the harshest stability zone for pharmaceuticals, which subjects the product to extreme humidity and high temperature requirements. The liquid­filled capsules utilized capsule banding, a thin, liquid strip of gelatin or HPMC to seal the joint between the body and cap of a locked capsule. This method provided several benefits, including superior leak prevention, strengthening of the capsule, and extended product shelf life and formula potency.

Michael F. Smith, Formulation Manager at Vantage Nutrition, said, “We were delighted to launch the new VitaCholine® liquid capsules in a unique liquid fill dosage form based on a novel, patent-pending process that utilizes a DES (Deep Eutectic Solvent System), allowing for an increased level of free choline. This unique aqueous process enables us to deliver higher levels of free choline than previously possible.”

Vantage Nutrition

At Supply Side West 2024, Vantage Nutrition (an ACG group company) launched VitaCholine® in liquid capsules at a much higher concentration than had been previously achieved. VitaCholine® is the world’s leading brand of choline and an essential nutrient that has been clinically studied to show improvements in neuromotor function and brain health. Choline also plays a critical role in fetal brain development, passing from mother to child in utero. It is a component of the primary neurotransmitter acetylcholine, help-

Rafael Costa, Vice President, added, “Vantage Nutrition’s vertically integrated approach allows us comprehensive oversight of the customer experience, offering full turnkey solutions from concept to commercialization of finished packaged goods. This approach helps customers bring products to market faster and reduces lead time. We were excited to launch this new formulation of VitaCholine® at these achieved concentrations, quickly providing customers with the solutions they need.”

https://vantage-nutrition.com/

Infertility: Targeting Male Factors with the Latest Available Evidence on Carob (Ceratonia Siliqua)

The demand for fertility services is growing, with an increased focus on addressing male infertility, despite the challenges in diagnosis and effective treatment. Dietary supplements are becoming a popular option for men seeking fertility solutions.

AUTHOR: Anna Wittmann, Health and Nutrition Ghostwriter, MSc in Public Health Nutrition

The rising demand for fertility services and assisted reproductive technology seeks to support couples facing infertility1, with a strong emphasis on gender equality2. Addressing male fertility issues raises the question of how best to meet men’s specific needs, especially given the uncertain future supply of reproductive urologists1

We need stigma­free, affordable, and accessible solutions to improve adequate body functions in men. Bundled with the knowledge from science which factors can enhance sperm count, motility, and morphology to make an impact.

Compressed in an effective daily dose that

doesn´t hurt but could create new possibilities for parenthood.

Supplements as superheroes (or lack thereof)

The more you know, the smarter you are. Including physical, genetic, hormonal, or environmental factors as causes for male infertility can complicate diagnosis and treatment3. Not being able to pinpoint the exact cause in every individual often requires a lot of specialists, a lot of time, a lot of money, a lot of uncertainty, and a lot of emotions. Hope is diminished in a minimum of 25% cases,

where male infertility is idiopathic despite a thorough medical examination3

But not pinpointing an identifiable cause does not mean, men get stocked in a dead end.

It starts with insufficient evidence to support the use of fertility supplementation, and health providers may be reluctant to recommendations3. But it continues with sufficient evidence for a growing use of dietary supplements, and men are curious and looking for answers. And the use of over-the-counter supplements and its market is growing exponentially4

And the more ingredients they have, the better they are.

Including the whole rainbow from broccoli to rose hips for male infertility can make it harder for suppliers on the market to stay reliable. Because only a few ingredients used in popular fertility supplements have positive evidence3 (Table 1).

Being able to find a new “Holy Grail Ingredient” requires often a lot of research, a lot of time, a lot of money, a lot of certainty, and a lot of rationalism. And pinpointing carob could be a new guest on the red carpet. In your portfolio and listing. So, take a look.

Evidence-based conclusions

on the effectiveness of carob (Ceratonia siliqua) for sperm quality

Found in Italy, Iran, and Turkey the carob tree (Ceratonia siliqua) is highlighted for its beneficial effects on the intestinal microbiome and glucose metabolism and has demonstrated anti-diabetic and anti­inflammatory properties5. Especially the phenolic profile from carob pulps, powders, and syrups has been associated with anti-cancer and neuroprotective benefits6

His potential as a functional food and therapeutic dietary supplement to enhance human health7 (Figure 1.) raises attention to its antioxidant properties to help reduce oxidative stress and minimize cellular damage.

Packed with polyphenols, and a wide range of macro (K, Ca, Mg, P) and trace minerals (Mn, Fe, Zn, Cu) and vitamins8, carob as a medical plant is traditionally used to improve semen quality. Affordable and accessible with minimal side effects, infertile men could benefit from combating oxidative stress, as studies show that they have lower antioxidant capacity than

TABLE 1 Evidence for each ingredient on sperm parameters and/or live birth rates

Zinc

and

antibodies.

According to Kuchakulla et al. All other ingredients are designated

Nutrients:

Dietary fiber

Carbohydrate

Calories

Protein

Vitamins: Riboflavin

Vitamin B6

Niacin

Folate

Helps to prevent cancer

Beneficial in managing diabetes

Reduce risk of cardio vascular diseases

Minerals: Calcium

Copper

Manganese

Potassium

Helps to improve digestion and prevents gastrointestinal conditions

Aids in weight loss by reducing chances of overeating

AccordingtoIkrametal.

fertile men9

To demonstrate the impact of carob supplements on sperm quality and parameters in infertile men, Yildiz et al.10 conducted a systematic review and meta-analysis. Articles were searched up to November 2023 with relevant terms and MeSH-based keywords in PubMed (MEDLINE), Cochrane, Google Scholar, Scopus, and Web of Science.

To be included participants had to be aged 20–45 years, with a history of infertility complaints for at least 12 months, and no record of surgical or medical treatments for infertility, having a BMI less than 30, exhibiting oligo-spermatozoa according to WHO criteria (sperm concentration less than 15 million per ml, type A motility less than 25%, and type B mobility less than 50%, normal morphology less than 15%).

From the initial 114 studies, four studies with a total of 236 infertile men evaluated the effect of carob supplementation in infertile men on sperm characteristics (primary outcomes: sperm motility, sperm count, sperm volume) and reproductive hormone parameters (secondary outcomes: Malondialdehyde, Luteinizing, Follicle Stimulating Hormone, Testosterone).

The participants in the intervention group received carob (Ceratoniasiliqua) supplements at a specified dose, along with a standard diet, for the duration of the treatment period as detailed below:

• Carob capsules 400 mg were delivered twice a daily for 12 weeks with Pentoxifylline capsules 400 mg twice a daily for 12 weeks

• Carob once 1.5 g daily for 12 weeks Carob capsules 500 mg three times a day for 90 days

• Carob syrup (100 g Carob in 500 ml water, after filtration mixed with 500 ml USP syrup) 7,5 ml twice a day for 3 months.

The participants in the direct comparison group were infertile men without carob interventions and

received:

• 30-min acupuncture sessions for 12 weeks (the first month, two sessions per week; the next 2 months, one session per week, and 16 sessions) Placebo with lactose for 12 weeks

• Vitamin E capsules three times a day for 90 days.

After 12 weeks of carob supplementation, the following outcomes were observed:

Semen motility

• The meta-analysis revealed that all included studies assessed the impact of carob on semen motility.

The intervention led to a significant improvement in semen motility, with results showing a positive effect in the intervention groups.

Semen volume

The meta-analysis revealed that only two studies reported on the impact of carob on semen volume.

While the combined data indicated a positive effect, the overall effect size was small and not statistically significant. Despite the variability in effect sizes, each individual study demonstrated a positive association between carob consumption and increased semen volume.

Semen count

The meta-analysis revealed that three included studies reported results on the effect of carob on semen count.

In these studies, the association with the effect size of carob on semen quantity was positive and statistically significant.

Hormonal parameters

• Meta­analyses revealed significant differences in hormone only for malondialdehyde, where the value decreased in the intervention group compared to the control group. The pooled effect sizes of Luteinizing, Follicle-Stimulating Hormone, Testosterone, and total hormone parameter domains were all small.

Conclusion

As seen in the studies the available evidence to date reveals, that the rich bioactive profile of carob as a natural source of antioxidants positively affects semen count, volume, and motility after 12 weeks of supplementation with a dose between 800-1500 mg daily. Although evidence is limited, carob extract has also been associated with enhanced semen quality and increased testosterone levels.

Nevertheless, it is imperative to verify these results on the effects of carob and the amount of effective use. Taking into account, placebo-controlled studies with larger sample sizes and including not only individuals' weight status, but adequate sleep, and activity levels as more robust and effective responses than any nutraceutical in managing sperm parameters9. Especially in contrast or addition to L-carnitine, Vitamin E, Vitamin C, CoQ10, and Zinc as few ingredients in popular men's fertility supple-

FIGURE 1 Health benefits of carob (Ceratoniasiliqua)

ments with already positive evidence3

According to EFSA and health claims regulation, only the relevant statement "selenium contributes to normal spermatogenesis" 11 is permitted on supplements in the EU, based on scientific evidence regarding its physiological function in male fertility. Since dietary supplements do not have reliable or strict regulations on their efficacy and safety by the FDA12, they should be used with caution. And formulated by manufacturers with scientific evidence of effective ingredients and safety as a health tool4 . Before personalized and prescripted by physicians and/or registered dietitians9

References:

1 Greenberg DR, Nam CS, Halpern JA. The increasing demand for reproductive urologists and male fertility care. F S Rep. 2024;5(2):125126. doi:10.1016/j.xfre.2024.05.001.

2 World Health Organization. Infertility prevalence estimates: 1990–2021. 2023. https://www.who.int/publications/i/item/ 97892 0068315. Accessed 27.09.2024.

3 Kuchakulla M, Soni Y, Patel P, Parekh N, Ramasamy R. A Systematic Review and Evidence-based Analysis of Ingredients in Popular Male Fertility Supplements. Urology. 2020;136:133-141. doi:10.1016/j. urology.2019.11.007.

4 Djaoudene O, Romano A, Bradai YD, et al. A Global Overview of Dietary Supplements: Regulation, Market Trends, Usage during the COVID­19 Pandemic, and Health Effects. Nutrients. 2023;15(15). doi:10.3390/nu15153320.

5 Micheletti C, Medori MC, Bonetti G, et al. Effects of Carob Extract on the Intestinal Microbiome and Glucose Metabolism: A Systematic Review and Meta-Analysis. Clin Ter. 2023;174(Suppl 2(6)):169172. doi:10.7417/CT.2023.2484.

6 Ioannou GD, Savva IK, Christou A, Stavrou IJ, Kapnissi-Christodoulou CP. Phenolic Profile, Antioxidant Activity, and Chemometric Classification of Carob Pulp and Products. Molecules. 2023;28(5). doi:10.3390/molecules28052269.

7 Ikram A, Khalid W, Wajeeha Zafar K-U, et al. Nutritional, biochemical, and clinical applications of carob: A review. Food Sci Nutr. 2023;11(7):3641-3654. doi:10.1002/fsn3.3367.

8 Laaraj S, Hussain A, Mouhaddach A, et al. Nutritional Benefits and Antihyperglycemic Potential of Carob Fruit (Ceratonia siliqua L.)An Overview. Ecol Eng Environ Technol. 2024;25(3):124-132. doi:10.12912/27197050/178456.

9 Santos HO, Cadegiani FA, Forbes SC. Nonpharmacological Interventions for the Management of Testosterone and Sperm Parameters: A Scoping Review. Clinical Therapeutics. 2022;44(8):11291149. doi:10.1016/j.clinthera.2022.06.006.

10 Karaahmet AY, Gençtürk N, Kınık E. The Effect of Carob (Ceratonia Siliqua) on Sperm Parameters of Infertile Men: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Reprod Sci. 2024;31(8):2481-2492. doi:10.1007/s43032-024-01534-7.

11 Scientific Opinion on the substantiation of health claims related to selenium and maintenance of normal hair (ID 281), maintenance of normal nails (ID 281), protection against heavy metals (ID 383), maintenance of normal joints (ID 409), maintenance of no. EFSA Journal. 2010;8(10):1727. doi:10.2903/j.efsa.2010.1727.

12 Facts about Dietary Supplements. FDA. Fri, August 9, 2024. https:// www.fda.gov/news-events/rumor-control/facts-about-dietary-supplements. Accessed September 23, 2024.

Anna Wittmann based in Nürnberg, Germany

https://wittmannwriting.com/ Ghostwriter for Health and Nutrition

M.Sc. Public Health Nutrition anna@wittmannwriting.com

Importance of Peruvian Anchoveta Fishery

A new Reuters documentary, Leading the Way: How SNP is Advancing Anchoveta Management in Peru, highlights Peru’s anchoveta fishery’s importance in global food security, health benefits from omega-3s, and its sustainability efforts.

Anew documentary published by global multimedia news agency Reuters titled “Leading the Way: How SNP is Advancing Anchoveta Management in Peru,” explores the significance of the Peruvian anchoveta fishery, a key source of EPA and DHA omega-3s.

Sponsored by the National Fisheries Society (SNP) of Peru, this documentary highlights anchoveta's critical role in human health and global food security as well as showcases the strides the fishery has made in sustainability.

The documentary, published last month as part of Reuters’ Ocean Titans series, features insights from the Global Organization for EPA and DHA Omega-3s (GOED) and the Food and Agriculture Organization of the United Nations (FAO), as well as a key fisheries expert from the University of Washington.

GOED’s Managing Director Ellen Schutt makes the connection between anchoveta and the health benefits of EPA and DHA for improving public health. “The Peruvian anchovy fishery is the largest fishery in the world that supplies anchovy oil,” Schutt said. “Anchovy… has a very high amount of EPA and DHA, making it an important source for the dietary supplement and human nutrition industry.”

The documentary also emphasizes the sustainability measures implemented in the anchoveta fishery. In recent years, SNP and associated companies have invested over US$500 million in technological innovations at anchoveta processing plants to reduce emissions and environmental impact. Fisheries expert and University of Washington professor Ray Hilborn praised the fishery as a model of sustainability for other global fisheries.

Despite the significance of the Peruvian anchoveta fishery, many people are unaware of its relevance to global food security and its sustainability story.

Watch the documentary here to learn more.

Sirio Launched its GummiBiotic Range at CPHI Milan

The new market-ready range included clinically-researched strains for immune health, IBS symptoms, and fat burning.

Sirio Pharma - the global nutraceutical contract development and manufacturing organisation (CDMO) - launched its new GummiBiotics™ at CPHI Milan for leading nutraceutical and healthcare brands. These innovative gummies were powered by branded, science-backed macrobiotic strains and were designed to support various health benefits. The range included three vegetarian gummies, each uniquely formulated for specific needs: GummiBiotics Defense to support immune health, GummiBiotics IBS Ease to alleviate IBS symptoms, and GummiBiotics Lean to aid in abdominal fat burning.

GummiBiotics by SIRIO were launched at the world’s largest pharma event as demand for natural alternative treatments for common health conditions continued to grow. The biotic supplement segment already accounted for a quarter of all supplements sold, surpassing $3bn in sales in 2023, with the gummy category growing at an average of 14% CAGR since 2020. Consumers were increasingly prioritising natural health solutions, while also looking for products that combined proven efficacy with enjoyable dose forms.

The GummiBiotics Defense was powered by 500 mg of EpiCor® postbiotic per serving – a unique ingredient that had been the focus of numerous clinical trials for immune and gut health – with added Zinc (5 mg) to support the normal function of the immune system. It was a first­to­market postbiotic and was expected to see rapid sales growth as the only gummy available featuring EpiCor®

Irritable Bowel Syndrome (IBS) was a common digestive disorder affecting 15% of people worldwide, causing symptoms like abdominal pain, bloating, diarrhoea, or constipation, and many consumers were looking for natural products to help manage symptoms. In another first, Sirio formulated its GummiBiotics IBS Ease with ADM’s proprietary ES1 Postbiotic - which, in clinical studies, was shown to help moderate some symptoms of IBS-D and deliver a reduction in occasional diarrhoea. The gummy was further enhanced with xylo-oligosaccharides - with a study showing that xylo-oligosaccharides could help comfort diarrhoea-dominant Irritable Bowel Syndrome (IBS-D) - and Calcium, which was known to contribute to the normal functioning of digestive enzymes.

The third new product launched was the GummiBiotics Lean, which featured a specially formulated combination of apple cider vinegar, Vitamin B6, and DE111® probiotic [containing 5bn CFU] - a strain of Bacillus subtilis clinically proven to significantly reduce body fat percentage. The gummy’s metabolic action was further enhanced by 500mg of Sirio’s own premium Apple Cider Vinegar Natuful™ Postbiotic. The formulation was market-ready, powered by science-backed microbiomes, and supported healthy body composition.

Sara Lesina, General Manager Sirio Europe & Americas, commented: “At Sirio we are very proud of our R&D capabilities, where we continue to invest a significant portion of our earnings: our technical and formulation teams account for 13% of our total employee base, something unique for a CDMO. We are constantly working with our customers and our experts to not just follow the trends but make first­inclass new products that will drive sales in new areas – and each one of these concepts is a true first for nutraceutical brands. So we are incredibly excited to launch the new GummiBiotics range as it continues building on our partnerships with some of the best ingredient suppliers and it combines the benefits of science-backed biotics with gummies that are truly delicious: this range will completely change the experience for consumers.”

* The study showed statistically significant results in improvements in IBS-SSS scores and quality of life scores (based on the IBS-QoL) compared to placebo, along with an improvement of frequency of watery stools compared to placebo, a significant reduction of mean APS-NRS score (related to abdominal discomfort) and a significant reduction in stress versus placebo, as measured by the State-Trait Anxiety Index (STAI).

medicinal plants photo herbarium

Blackberry (Rubus fruticosus L.)

Blackberry is a hardy shrub in the Rosaceae family, producing nutrient-dense black fruits rich in vitamins C and K, antioxidants, and fiber that support cardiovascular health, immune function, skin vitality, and digestive health, with leaves and roots traditionally used for their astringent, anti-inflammatory, and wound-healing properties.

Blackberry (Rubus fruticosus L.), a member of the Rosaceae family, is a perennial shrub known for its thorny stems, dark green leaves, and clusters of juicy, black, aggregate fruits. It is notable for its bramble-like growth, with arching, thorny canes that can grow between 1.5 to 3 meters in height, depending on the species and environment. Blackberry plants are characterized by their robust and resilient nature, thriving in diverse environments from forest edges to open fields, and often found in temperate regions worldwide. The blackberry plant blooms from spring to late summer, with small, white or pale pink flowers that measure approximately 2­3 cm in diameter. Each flower has five petals, a central cluster of numerous stamens, and is highly attractive to pollinators, especially bees. These flowers are critical for fruit production, as they develop into the familiar blackberry fruit after pollination. Blackberry fruit is not a true berry but an aggregate fruit, formed from multiple small drupelets clustered together on a receptacle. Each drupelet contains a single seed. The fruit starts as green, then transitions through red to a deep, glossy black as it ripens. The flavor is both sweet and slightly tart, making it a popular ingredient in culinary and medicinal applications.

Habitat & cultivation

Blackberry shrubs thrive in temperate climates and can tolerate various soil types, though they prefer well-drained, fertile soil. The plants are highly adaptable and can grow in partial shade but produce the best yields in full sun. Harvesting typically occurs in late summer to early autumn when the berries have fully ripened to a deep black color.

Use for medicinal purposes

Blackberries are rich in vitamins (particularly vitamin C and K), fiber, and antioxidants, including anthocyanins, which give the berries their dark color. These compounds are known for their health benefits, such as supporting immune function, promoting skin health, and improving cardiovascular health. Blackberry leaves and roots have traditionally been used as a natural remedy for diarrhea and sore throats due to their astringent properties.

Traditional medicinal uses

Historically, blackberry roots and leaves were used in teas and poultices to treat digestive disorders, alleviate mouth and throat infections, and aid

wound healing. The fruit was also consumed to promote blood purification and general well­being. In various cultures, blackberry was considered a protective plant, and its parts were used in folk remedies for boosting immune function and soothing skin ailments.

Constituents

Anthocyanins

Vitamins (C, K)

• Dietary fiber

• Tannins

• Polyphenols

• Minerals (e.g., manganese, folate)

Action and application

Blackberries offer a wide range of health benefits, primarily due to their high levels of antioxidants and vitamins. They are used to promote cardiovascular health, improve digestive function, and support immune health. Their antioxidant properties contribute to anti­aging effects and skin vitality, while their astringent properties make blackberry leaves beneficial for wound care and oral health. Blackberries are an excellent source of dietary fiber, particularly soluble fiber, which supports healthy digestion, regular bowel movements, and microbiome diversity. The astringent properties of blackberry leaves and roots also aid in managing diarrhea.

References:

1 Wu, X., Beecher, G. R., Holden, J. M., Haytowitz, D. B., Gebhardt, S. E., & Prior, R. L. (2004). "Lipophilic and hydrophilic antioxidant capacities of common foods in the United States." Journal of Agricultural and Food Chemistry, 52(12), 4026–4037. DOI: 10.1021/jf049696w.

2 Slavin, J. L. (2013). "Fiber and prebiotics: Mechanisms and health benefits." Nutrients, 5(4), 1417­1435. DOI: 10.3390/nu5041417.

3 Del Rio, D., Costa, L. G., Lean, M. E. J., & Crozier, A. (2010). "Polyphenols and health: What compounds are involved?" Food & Function, 1(1), 99-111. DOI: 10.1039/c0fo00120e.

TAXONOMY

kingdom: Plantae

order: Rosales family: Rosaceae

genus: Rubus

species: Rubus fructiosus

COMMON NAME

Blackberry

FLOWERING TIME IV-VIII month

Regulation of Retinol Application in Cosmetics on the European Union Market

The European Union is set to introduce new regulations limiting the use of retinol and its derivatives in cosmetics to 0.05% Retinol Equivalent (RE) in body lotions and 0.3% in other products. These changes, anticipated by late 2023, will require product labels to state that Vitamin A compounds contribute to daily intake levels. Cosmetics manufacturers will have 18 to 36 months to comply with these new standards.

AUTHOR:

Gordana Gorinšek, MSc in Phytomedicine, Expert Cosmetic Safety Assessor, Expert Regulatory Affairs Consultant

Currently, vitamin A is not regulated in the annexes of the Cosmetics Regulation (EC) No. 1223/2009. The use of vitamin A forms in cosmetics production is not yet subject to legal bans or restrictions, but changes in legal regulations are expected soon, likely within the next few months. The European Commission plans to officially announce an amendment to the Regulation in the last quarter of 2023.

On June 8, 2023, the European Commission notified the WTO (World Trade Organization) about the draft amendment of Regulation (EC) No. 1223/2009 of the European Parliament and the Council on cosmetics, regarding the use of vitamin A compounds, arbutin, alpha-arbutin, triclosan, triclocarban, kojic acid, daidzein, genistein, and 4-methylbenzylidene camphor.

Based on the latest opinion of the Scientific Committee on Consumer Safety (SCCS), the European Commission has prepared a draft regulation that amends Annexes II, III, V, and VI.

In Annex III of the Regulation (EC) No. 1223/2009,

which lists substances that cosmetic products may not contain except under the specified conditions (allowed only within listed limits), restrictions on the use of vitamin A compounds will be introduced.

SCCS has established maximum limits for the safe use of vitamin A in cosmetic products. The European Commission has translated these into the new draft regulation. The restrictions apply to the following forms of vitamin A: retinol, retinyl acetate, and retinyl palmitate. These substances will be allowed for use up to a maximum concentration of 0.05% Retinol Equivalent (RE) in body lotions and up to 0.3% RE in other products that remain on the skin for an extended period (except for body lotions), as well as in rinse­off products.

The labeling of these products will also have to include a note stating: "Contains Vitamin A-related compounds, which contribute to your daily intake of Vitamin A."

The draft sets deadlines for the implementation of the new legal provisions, allowing the cosmetics industry time to adapt. Newly introduced products

will have an 18-month deadline, while existing products on the market will have 36 months to comply, starting from the date the new legal provisions come into force.

If you are a cosmetics manufacturer, review the formulations of your products and take necessary actions to ensure compliance with the new legal provisions on time.

Chronology and reasons

Vitamin A is a fat-soluble vitamin and an essential micronutrient for most mammalian species. Vitamin A and its derivatives are present in various foods (fish, eggs, dairy products, etc.) and supplements, but humans are also exposed to vitamin A from other sources, including cosmetics. According to the opinion of the European Food Safety Authority (EFSA), the upper limit for vitamin A intake in the body is 3000 µg RE/day for all age groups.

Retinol, retinyl acetate, and retinyl palmitate are active cosmetic ingredients that induce collagen biosynthesis in the skin while simultaneously inhibiting UV-induced collagen degradation enzymes. A cosmetic product containing these ingredients is expected to contribute to improving the appearance of the skin affected by natural aging and photoaging processes.

Responding to a request from the EU member states to assess the safety of vitamin A, SCCS published its opinion in October 2016 (SCCS/1576/16) and concluded that vitamin A is safe when used as a cosmetic ingredient in:

Body lotions at concentrations up to 0.05% Retinol Equivalent (RE),

• Hand or face creams and other products that remain on the skin for an extended period (except for body lotions), as well as rinse­off products, up to a concentration of 0.3% RE.

In 2020, SCCS received additional information regarding exposure to vitamin A and the contribution of cosmetics to total vitamin A exposure. In light of the received information, SCCS conducted another safety assessment and formed a revised opinion, published in October 2022.

In the revised opinion, SCCS reiterated its 2016 conclusion. Additionally, SCCS warned that exposure to vitamin A from food and supplements in the most exposed consumers (5% of the total population) might exceed the upper limit, to which cosmetics also contribute. The contribution of vitamin A from cosmetics is smaller, but it increases the overall exposure of consumers.

Aromatični kutak Ltd.

Brune Bušića 21 Zagreb, Croatia https://pif.com.hr/ info@aromaticnikutak.hr T. + 385 98 1750 934

Launch of Powdered Nutraceutical for Skin Protection

To meet customer demand for a variety of galenic formulations, Seppic launches a powder grade of this ingredient in addition to the existing oil grade.

Dietary supplements are now an integral part of the well-being routines of consumers seeking products that are effective, safe and in line with their lifestyles. To meet these needs, brands are innovating and have been following a trend for several years towards the "foodification" of nutraceuticals. This results in the use of new galenics, flavors or textures, sometimes more complex formulations requiring the selection of ingredients with specific proprietes1 . Seppic addresses these challenges with Sepibliss™, offering two grades that can be easily formulated into:

• Reference formats: hard capsules, softgels, powders

• Emerging and trendy formats: gummies, liquids, chocolate bites, liposomal solutions.

This new powder grade expands the range of galenic formats that can be used for the formulation of finished products containing Sepibliss™. This ingredient also meets the growing consumers’ need for more naturality, as both grades are from natural origin. The coriander used to make Sepibliss™ comes from France, and is grown in a 20 km radius around the oil manufacturing plant.

The oil is extracted from coriander seeds by an eco-designed process that does not involve any solvent, additive or preservative. For the powder grade, only water is used as solvent.

Sepibliss™ Powder is guaranteed GMO-free, preservative-free, Halal and Kosher suitable and suitable for vegan formulas.

With the launch of this new grade, Seppic continues to strengthen its position as an expert in the field of nutraceutical ingredients, offering its partners more customized solutions.

References:

1 Charpentier, F., & Charpentier, F. (2023, 27 juillet). Nutraceutique : quand l’innovation rime avec galénique. Agence Web - les Phytonautes.

Egg Shell Membrane –Beauty from Within Benefits

Skin aging is a complex process that involves changes in texture, tone, and hydration, along with a reduction in collagen, elastin, and hyaluronic acid due to internal and external factors such as UV radiation and stress. Supplements like MKare®, which contain bioactive compounds such as collagen and hyaluronic acid, can help preserve elasticity, hydration, and skin recovery, with antioxidant and anti-inflammatory properties.

AUTHOR: Manuel La Nuez García, BSc in Chemistry, Arandovo, Departamento I+D

Skin aging is a dynamic and multifactorial process that manifests itself through a series of visible and perceptible changes. Beyond wrinkles and loss of elasticity, the skin experiences alterations in its texture, tone and hydration capacity.

These changes are the result of a complex interaction between intrinsic factors, such as genetics and hormonal changes, and extrinsic factors, such as exposure to ultraviolet radiation, pollution and oxidative stress. Understanding these mechanisms allows us to develop personalized strategies to maintain healthy and radiant skin over the years.

The skin acts as a protective barrier that defends us from external aggressions and regulates our body temperature. However, over time, this barrier weakens, which can affect both our physical appearance and our overall health.

Skin aging not only results in aesthetic changes but can also increase susceptibility to infections and

dermatological diseases.

Collagen, a vital structural protein, is key to maintaining skin firmness and elasticity. With age, collagen production declines while degradation increases, resulting in loss of volume, wrinkles, and decreased skin hydration. While aging is inevitable, we can mitigate its effects by protecting our skin from the sun, adopting a balanced diet, and using skincare products that promote collagen synthesis.

Nutrition plays a pivotal role in maintaining skin health. Essential nutrients like vitamins C and E, zinc, and omega-3 fatty acids act as antioxidants, shielding skin cells from oxidative damage. These nutrients also support the production of collagen and elastin, crucial proteins for skin structure and elasticity. By combining a balanced diet with targeted nutritional supplements, we can optimize our skin's health and radiance.

Repairing damaged tissue is a complex process involving the interaction of multiple factors. Essential

amino acids such as those present in collagen and elastin, together with glycosaminoglycan precursors such as hyaluronic acid and chondroitin sulfate, are the fundamental building blocks for skin regeneration. These components, present in many foods and supplements, stimulate cell proliferation, the synthesis of new collagen fibers and the formation of a healthy extracellular matrix, thus promoting the repair of damaged tissues and the restoration of the skin barrier.

Potential benefits of cosmetic supplements:

• Skin hydration: Many cosmetic supplements aim to increase skin hydration, leading to a smoother, more youthful appearance.

• Wrinkle reduction: By promoting collagen and elastin production, some supplements may help reduce the appearance of wrinkles and fine lines.

• Skin elasticity: Increased levels of collagen and elastin may improve skin elasticity, making it less prone to sagging and wrinkles.

• Protection from environmental damage: Antioxidants in cosmetic supplements may help protect the skin from harmful environmental factors such as ultraviolet radiation and pollution.

MKare® in skin formulations:

MKare® is a 100% natural ingredient derived from fresh eggshell membrane (ESM), has a rich composition in bioactive compounds like collagen, hyaluronic acid, and elastin. These components are beneficial for managing osteoarthritis (OA) due to their anti­inflammatory and regenerative properties.

With aging and unprotected skin from the sun, the skin levels of elastin, collagen and hyaluronic acid gradually decrease, contributing to the loss of structuralintegrity and elasticity. The oral intake of supplements that provide these nutrients can be an alternative to minimize this loss.

MKare® is a natural and unique ingredient for skin protection and regeneration that acts from oral administration and largely shares the same molecular composition of the skin structure.

Collagen: It constitutes approximately 75% of the skin's composition. It confers resistance and support to the tissues. MKare® contains around 25% of this protein, being of type I, V and X, which are very important for the maintenance and restoration of the composition in the tissues.

Elastin: It constitutes 2% to 4% of the dry weight of the dermis in adults. It is the protein that confers elasticity on the tissues to provide stretching and recoil to the skin. MKARE® contains more than 20% of this protein, which is so important for maintaining and restoring the firmness and elasticity of the skin.

Hyaluronic Acid: Skin aging is associated with the loss of hydration and hyaluronic acid is vital molecule for maintaining hydrated skin as it has the ability to retain water in the tissues. MKARE® contains more than 4% of this molecule.

Mkare® Egg shell membrane derivate as skin protection: The anti­inflammatory and antioxidant properties of MKARE® can play a significant role on skin protection by reducing the factors responsible for inflammation, as well as free radicals generated

by environmental pollutants and solar radiation.

MKare® in hair and nail formulations:

MKare® has other components that make the ingredient much more effective than a supplement based on collagen, elastin and hyaluronic acid since it contains cysteine rich proteins (27%), an amino acid precursor of two molecules with high benefits for our tissues, glutathione, which is the antioxidant molecule that protects our tissues from oxidative stress and Taurine, which provides energy to our cells.

At Arandovo, we continue to research MKARE®, our 100% natural functional ingredient obtained without the intervention of any chemical agent. An innovative product with multiple health benefits.

References:

1 Schoenfeld, Pamela. Colágeno: Rejuvenece tu piel, fortalece las articulaciones, y siéntete más joven gracias a la dieta que aumenta la producción y el consumo de colágeno. EDITORIAL SIRIO SA, 2020.

2 Kielty, Cay M., Michael J. Sherratt, and C. Adrian Shuttleworth. "Elastic fibres." Journal of cell science 115.14 (2002): 2817­2828.

3 Ahmed, Tamer AE, Henri-Pierre Suso, and Maxwell T. Hincke. "Indepth comparative analysis of the chicken eggshell membrane proteome." Journal of proteomics 155 (2017): 49-62.

4 Ahmed, Tamer AE, Henri-Pierre Suso, and Maxwell T. Hincke. "Experimental datasets on processed eggshell membrane powder for wound healing." Data in brief 26 (2019): 104457.

5 Kagan, H.M. and Li, W. (2003). Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. Journal of Cellular Biochemistry, 88(4), 660-672.

Arnadovo S.L.

www.arandovo.com/

T. +34 675 775 844

market watch:

Fraktal Glacial Line –Cooling Cosmetics

Fraktal Beauty is Croatia's first skincare brand created specifically for women in perimenopause and menopause. This brand's product line offers products like Glacial Cooling Spray and Gel Cream to combat hot flashes, dehydration, and environmental stressors, with clinically proven cooling and hydrating effects.

Fraktal Beauty is the first Croatian brand that was introduced to the market as a skincare brand for women who are dealing with symptoms of perimenopause and menopause, in order to provide them with care for dehydrated and dry skin, anti-aging care and protection from modern environmental aggressors, and restore hydration to the skin and healthy glow. Fractal products are specific in that they have been tested for effectiveness, and therefore offer proven results on the skin.

The appearance of a sudden heat wave, better known as a hot flush, is one of the most common symptoms of perimenopause and menopause. According to many studies, almost 80% of women in

perimenopause and menopause, and even in postmenopause, have hot flashes, which can be of various intensities. Also, hot flashes can last up to 10 years. Considering how unpleasant an experience they can be for any woman, this phenomenon is indeed a dominant phenomenon of perimenopause, menopause and postmenopause for many women.

As a result of heat waves, which often result in sweating of the face and décolleté, the skin becomes dehydrated.

With the idea of helping women with hot flushes and consequent dehydration of the skin, Glacial Cooling spray and Glacial Cooling gel cream were created, both with a cooling effect and instant hydration.

Efficiency tests of Fractal Glacial Cooling Spray and Gel Cream have proven that these products provide an instant reduction in skin temperature of 2.3 °C in just three minutes. They currently hydrate the skin up to 45%, and 100% of respondents confirmed the feeling of coolness on the skin, as well as the feeling of freshness. It will provide effective cooling to the skin that can last up to 20 minutes.

Glacial products can be used during the day or night, for relief from hot flashes or whenever cooling is needed. The spray is the perfect instant solution that can always be kept with you in your purse, while the fast-absorbing gel cream can be applied as needed and several times a day.

The cooling effect on the skin, without causing an irritation, is due to a scientifically proven formula consisting of a fermented extract of the Albatrellus confluens mushroom, with a strong cooling and soothing effect, and hyperfermented Aloe Vera juice, which significantly improves skin hydration and soothes it. Glacial Cooling spray and Glacial Cooling gel cream are suitable for all skin types, they are dermatologically tested and can be used daily, all year round.

All products are available through the web shop: https://fraktalbeauty.com/ and in selected pharmacies. www.fraktalbeauty.com