FRCPath Part1 Course
Special stains and Immunohistochemistry MCQ 1 A 69 year old male with history of asbestos exposure presents with pleural effusion: The CT scan shows diffuse left sided pleural thickening. The pleural cytology shows clusters of atypical cells with an epithelioid morphology which are immunohistochemically AE1/3 and CK7 positive, but negative for BerEP4, CEA, TTF1, CK20, CD34 and desmin. The likely diagnosis is: A. B. C. D. E.
Pulmonary adenocarcinoma. Malignant mesothelioma. Small cell carcinoma. Malignant solitary fibrous tumour. Epithelioid leiomyosarcoma.
MCQ 2 CD34 is positive in which of the following tumours: A. Dermatofibrosarcoma protuberans. B. Solitary fibrous tumour. C. Gastrointestinal stromal tumour. D. Spindle cell lipoma. E. All of the above. MCQ 3 The commonest phenotype of primary ovarian mucinous cystadenocarcinoma is: A. B. C. D. E.
CK7 positive/CK20 negative. CK7 negative/CK20 positive. CK7 negative/CK20 negative. CK7 diffuse positive/CK20 patchy positive CK7 patchy positive/CK20 diffuse positive.
MCQ 4 An 80 year old man undergoes a skin excision biopsy for an ill-defined nodule on the face measuring 2cm in diameter: Histologically the epidermis is atrophic but otherwise normal. The sun-damaged dermis shows a pleomorphic spindle cell lesion with many mitotic figures, which does not extend into the subcutaneous tissue. Immunohistochemically, the tumour cells are negative for AE1/3, MNF116, S100, smooth muscle actin and desmin. The most likely diagnosis is: A. Spindle cell carcinoma. B. Synovial sarcoma C. Cutaneous leiomyosarcoma. D. Atypical fibroxanthoma E. Malignant melanoma.
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