Advancing the Frontiers of Medicine Endowed Chairs, Professorships, and Fellowships 2016
This page: Lionel B. Ivashkiv, MD, Richard L. Menschel Chair and Chief Scientific Officer and David H. Koch Chair for Arthritis and Tissue Degeneration Research
Cover: Franck Barrat, PhD, Michael R. Bloomberg Chair in Autoimmune Diseases (left); Inez Rogatsky, PhD, Robert and Gillian Steel Fellowship in Musculoskeletal Research (center); Roger F. Widmann, MD, Leon Root MD Chair in Pediatric Orthopaedics, and Scott Rodeo, MD (right) 2 ADVANCING THE FRONTIERS OF MEDICINE
Endowed Chairs, Professorships, and Fellowships 2016
Enduring Support, Lasting Recognition Endowed chairs, professorships, and fellowships are the most coveted positions an institution can bestow upon its faculty and staff. Thanks to the support of generous and visionary benefactors, Hospital for Special Surgery continues to establish these prestigious positions, which honor the accomplishments of the physicians and scientists who hold them, and create lasting legacies for the individuals and foundations who have made them possible. ENDOWED CHAIRS AND PROFESSORSHIPS (28)
Starr Chair in Mineralized Tissue Research
Korein-Wilson Professorship in Orthopaedic Surgery
Starr Chair in Tissue Engineering Research
Benjamin M. Rosen Chair in Immunology and Inflammation Research
Russell F. Warren Research Chair
Joseph P. Routh Professor of Rheumatic Diseases in Medicine
NAMED FELLOWSHIPS (16)
Richard L. Menschel Chair and Chief Scientific Officer
Robert and Helen Appel Fellowship in Biomedical Engineering
David H. Koch Chair for Arthritis and Tissue Degeneration Research
Finn and Barbara Caspersen Fellowship for Spine Research
Michael R. Bloomberg Chair in Autoimmune Diseases
Charles L. Christian Research Fellowship
Franchellie M. Cadwell Chair
Ira W. DeCamp Fellowship in Musculoskeletal Genetics
Coleman Chair in Magnetic Resonance Imaging Research
Leo Farbman Fellowship for Pediatric Musculoskeletal Research
The Anne and Joel Ehrenkranz Chair in Hand and Upper Extremity Research The Anne and Joel Ehrenkranz Chair in Perioperative Medicine Allan E. Inglis MD Chair in Surgical Arthritis John N. Insall Chair in Knee Surgery Collette Kean Research Chair F.M. Kirby Chair in Orthopaedic Biomechanics David B. Levine MD Chair in Scoliosis Richard S. Laskin MD Chair in Musculoskeletal Education C. Ronald MacKenzie MD Chair in Ethics and Medicine Stephen A. Paget MD Chair in Rheumatology Chitranjan S. Ranawat MD Chair in Adult Reconstruction and Joint Replacement Leon Root MD Chair in Pediatric Orthopaedics Virginia F. and William R. Salomon Chair in Musculoskeletal Research Eduardo A. Salvati MD Chair in Hip Arthroplasty Thomas P. Sculco MD Chair in Orthopaedic Surgery The Peter Jay Sharp Chair in Lupus Research
Ken and Jill Iscol Fellowship in Orthopaedic Research Helen Frankenthaler Fellowship in Restorative Mobility Mary Rodgers and Henry Guettel Fellowship in Biomedical Mechanics Michael D. Lockshin Fellowship of the Barbara Volcker Center for Women and Rheumatic Disease Irving and Sally Lipstock Fellowship in Orthopedic Surgery Ludwig Fellowship for Womenâ€™s Sports Medicine Research Stavros Niarchos Foundation-Thomas P. Sculco MD International Orthopaedic Fellowship Robert and Gillian Steel Fellowship in Musculoskeletal Research Nancy Dickerson Whitehead Research Fellowship Fellowship in Arthroplasty Immunology and Inflammation Fellowship For more information on how to contribute to the establishment of an endowed chair, professorship, or fellowship at HSS, please contact Robin Merle, Senior Vice President and Chief Development Officer, at 212.606.1201.
St. Giles Research Chair
ENDOWED CHAIRS, PROFESSORSHIPS, AND FELLOWSHIPS 2016 3
2016 Endowed Chairs and Professorships KOREIN-WILSON PROFESSORSHIP IN ORTHOPAEDIC SURGERY Todd J. Albert, MD
RICHARD L. MENSCHEL CHAIR AND CHIEF SCIENTIFIC OFFICER Lionel B. Ivashkiv, MD
Dr. Todd Albert is Surgeon-inChief and a world-renowned orthopedic spine surgeon specializing in the field of cervical spine surgery. As a physician-scientist, Dr. Albert conducts research focused on disc degeneration with the goal of developing new therapies, including the use of stem cells for disc regeneration. He also examines the outcomes of surgical versus nonsurgical treatment and compares various surgical approaches to spinal pathologies.
Dr. Lionel Ivashkiv is Chief Scientific Officer and a premier scientist in inflammatory and musculoskeletal diseases. Dr. Ivashkiv oversees the Hospital’s clinical, translational, and basic research programs, which encompass over 200 scientists and staff working to identify the causes of and new treatments for musculoskeletal and autoimmune diseases. As CSO, Dr. Ivashkiv is working to develop and execute strategic plans to build and enhance HSS’ position as an international leader in orthopedic and rheumatic disease research. Under his leadership, long-term research goals include expanding translational research; building multidisciplinary teams to answer key clinical questions, enhancing clinical research; and broadening the scope and impact of basic science on musculoskeletal disorders, with a focus on tissue repair, genomics, new treatments, and precision medicine.
BENJAMIN M. ROSEN CHAIR IN IMMUNOLOGY AND INFLAMMATION RESEARCH Mar y K. Crow, MD Dr. Mary Crow, HSS Physicianin-Chief and Chair of the Division of Rheumatology, studies the immunologic basis of systemic autoimmune diseases with support from the Benjamin M. Rosen Chair in Immunology and Inflammation Research. Her research is focused on patients with systemic lupus erythematosus with the goal of identifying molecular and cellular mechanisms that might be therapeutically targeted to control disease activity and prevent disease flares.
JOSEPH P. ROUTH PROFESSOR OF RHEUMATIC DISEASES IN MEDICINE Mar y K. Crow, MD The Joseph P. Routh Professorship of Rheumatic Diseases in Medicine supports Dr. Mary Crow (pictured above), the Hospital’s Physician-in-Chief and Chair of the Division of Rheumatology. She is Past President of the American College of Rheumatology and currently serves as Director of the Autoimmunity and Inflammation Research Program at HSS. The Routh Professorship serves to honor and support the Physician-in-Chief’s leadership role in guiding the Hospital’s Department of Medicine faculty to achieve the highest level of academic accomplishment and innovative patient care.
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DAVID H. KOCH CHAIR FOR ARTHRITIS AND TISSUE DEGENERATION RESEARCH Lionel B. Ivashkiv, MD Dr. Lionel Ivashkiv (pictured above), is Chief Scientific Officer and a leading authority in the field of cytokine research. Cytokines are proteins that play a critical role in inflammation, arthritis, and many rheumatic and orthopedic conditions. Dr. Ivashkiv’s laboratory has identified potential new therapeutic targets for inhibiting the chronic inflammation and bone destruction that are characteristic of many musculoskeletal diseases, including rheumatoid arthritis and orthopedic implant loosening/osteolysis. Dr. Ivashkiv has described new therapeutic approaches for combating lupus. As the Director of the David Z. Rosensweig Center for Genomics Research at HSS, Dr. Ivashkiv is leading the application of advanced genomic technologies to study patients with musculoskeletal diseases to discover molecular pathways that can be targeted therapeutically. This precision medicine approach promises to provide personalized treatments for patients with orthopedic and rheumatologic conditions.
2016 Endowed Chairs and Professorships
MICHAEL R. BLOOMBERG CHAIR IN AUTOIMMUNE DISEASES Franck Barrat, PhD
COLEMAN CHAIR IN MAGNETIC RESONANCE IMAGING RESEARCH Hollis G. Potter, MD
Dr. Franck Barrat is a Senior Scientist in the Autoimmunity and Inflammation Program, a member of the David Z. Rosensweig Genomics Research Center, and Professor at Weill Cornell Medical College. His research is focused on lupus and scleroderma, two complex and incapacitating disorders for which there are currently no cures and for which more effective treatments are needed. Dr. Barrat’s expertise is in the function and regulation of immune system cells in disease settings, and he has extensive experience in the development of novel therapeutics in autoimmune and inflammatory diseases. Dr. Barrat aims to provide patients with effective therapies that target the actual disease-causing mechanisms rather than merely ameliorating symptoms, using a rare combination of skill in drug development and world-renowned expertise in the molecular pathways of these disorders. Dr. Barrat is now extending his research to study lupus and scleroderma at the epigenetic level, one of the most promising areas that will help illuminate the critical interaction between nature and nurture in the development of these diseases.
Dr. Hollis Potter is Chair and Director of Research for the Department of Radiology and Imaging. She is also an Attending Radiologist and Senior Scientist at HSS, as well as a Professor of Radiology at Weill Cornell Medical College. Her research interests lie in the use of MR imaging techniques to identify early depletion of matrix from cartilage and fibrocartilage, as well as the assessment of adverse synovial responses to orthopedic implants and biomaterials. Dr. Potter is Director of the NIH-funded MRI laboratory, whose scientists are translating noninvasive MRI techniques to clinical application and linking those techniques to meniscus, tendon, and ligament mechanical properties. She is the recipient of many prestigious awards and honors and is funded for both clinical and basic science MRI research by the NIH-NIAMS, industry, and educational granting agencies. Many of Dr. Potter’s current basic science imaging projects have been successfully translated into clinical use and implementation.
FRANCHELLIE M. CADWELL CHAIR Sergio Schwartzman, MD As one of Hospital for Special Surgery’s leading clinical rheumatologists, Dr. Sergio Schwartzman has dedicated his career to battling autoimmune diseases. Dr. Schwartzman is an Associate Attending Physician at HSS and Associate Professor of Clinical Medicine at Weill Cornell Medical College. He has an established clinical and research interest in autoimmune Ophthalmic Diseases, Psoriatic Arthritis, Ankylosing Spondylitis, Rheumatoid Arthritis, and Inflammatory Bowel Disease (Crohn’s and Ulcerative Colitis) associated arthritis.
THE ANNE AND JOEL EHRENKRANZ CHAIR IN HAND AND UPPER EXTREMITY RESEARCH Robert N. Hotchkiss, MD Dr. Robert Hotchkiss is Director of Clinical Research, Director of Research in the Hand and Upper Extremity Service, and Chief Innovation Officer at HSS. He is also an active member of the clinical staff as an Associate Attending Orthopaedic Surgeon treating conditions of the elbow, wrist, and hand. Under Dr. Hotchkiss’ direction, the Ehrenkranz Chair supports translational and clinical research in the conditions that affect many of our patients, including fracture care in the aging population; novel and emerging technologies in joint replacement of the upper limb; and collaboration with the Division of Rheumatology in the management of vascular diseases of the hand in patients affected by scleroderma and inflammatory arthritis of the upper limb. As the collaborative information technology used to study our patients improves, we will gain greater understanding of their needs, the nature of their diseases, and new opportunities for treatment. ENDOWED CHAIRS, PROFESSORSHIPS, AND FELLOWSHIPS 2016 5
2016 Endowed Chairs and Professorships
THE ANNE AND JOEL EHRENKRANZ CHAIR IN PERIOPERATIVE MEDICINE Linda A. Russell, MD Dr. Linda Russell is Director of Perioperative Services and Assistant Attending Physician at HSS. She is also an Assistant Professor of Medicine at Weill Cornell Medical College. The Anne and Joel Ehrenkranz Chair in Perioperative Medicine recognizes Dr. Russell’s outstanding leadership in establishing a comprehensive perioperative medical care program. Dr. Russell has designed and planned a research program focused on improvement of bone quality prior to spine surgery, and she has served as a co-principal investigator at HSS for an international study investigating cardiac outcomes following surgery. Currently, Dr. Russell is studying how to determine signs and symptoms of pulmonary embolism postoperatively. The Ehrenkranz Chair supports research that defines and implements new tools and strategies to optimize risk assessment of those planning to undergo surgery, as well as research that develops innovative mechanisms to achieve desired outcomes after surgery.
ALLAN E. INGLIS MD CHAIR IN SURGICAL ARTHRITIS Mark P. Figgie, MD The Allan E. Inglis MD Chair in Surgical Arthritis supports research activities under the direction of the Hospital’s Chief of the Surgical Arthritis Service, Dr. Mark Figgie. Research involves the study of joint replacement for inflammatory arthritis, including rheumatoid arthritis, juvenile inflammatory arthritis, lupus, psoriatic arthritis, and ankylosing spondylitis. Much of the research performed is a combined effort with members of the Division of Rheumatology. The Inglis Chair, supported by deferred and outright gifts, honors renowned orthopedic surgeon Dr. Allan E. Inglis, Sr., whose many years of remarkable service at Hospital for Special Surgery enriched the lives of thousands of patients, students, and colleagues.
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JOHN N. INSALL CHAIR IN KNEE SURGERY Steven Haas, MD Dr. Steven Haas, Chief of the Knee Service at HSS, is an internationally renowned surgeon and innovator in the design of knee implants. He has developed groundbreaking surgical techniques and instrumentation for performing Minimally Invasive Knee Replacement and has conducted extensive research in the field. Dr. Haas’ recent research interests have included improving knee replacement outcomes in younger, active patients; improving longevity in knee replacement by minimizing polyethylene wear; and reducing post-operative complications. He developed the first software solution to eliminate implant-related error in the operating room. Dr. Haas holds four U.S. patents for orthopedic devices and software he co-developed with HSS and others, and has several patents pending.
COLLETTE KEAN RESEARCH CHAIR Jane E. Salmon, MD Dr. Jane Salmon is a Senior Scientist, Director of the Lupus and APS Center of Excellence, and Co-Director of the Mary Kirkland Center for Lupus Research. She is also Associate Dean of Faculty Affairs at Weill Cornell Medicine. An internationally recognized investigator in lupus and other autoimmune diseases, her research focuses on the mechanisms by which autoimmune disease damages organs. Dr. Salmon’s basic and clinical studies have expanded our understanding of pregnancy complications and cardiovascular disease in patients with lupus, and determinants of disease severity and outcome in lupus. Her focus on circulating inflammatory proteins, autoantibodies (proteins that attack a patient’s own tissues), and immune-activated cells has allowed her to identify new targets to attenuate damage and improve outcomes in patients with autoimmune illness.
2016 Endowed Chairs and Professorships
F.M. KIRBY CHAIR IN ORTHOPAEDIC BIOMECHANICS Timothy M. Wright, PhD
RICHARD S. LASKIN MD CHAIR IN MUSCULOSKELETAL EDUCATION Charles N. Cornell, MD
Dr. Timothy Wright is a Senior Scientist and Director of the Department of Biomechanics. His research is focused on the mechanical performance of bone-implant systems and the role of joint stability in influencing the function of normal and reconstructed joints. In addition, he is collaborating on multidisciplinary approaches to explore the role of wear and corrosion products on influencing the outcomes of total joint replacements. Dr. Wright is also the Coordinating Program Director of the NIH-funded Clinical Translational Science Center at Weill Cornell Medical College.
The Richard S. Laskin MD Chair in Musculoskeletal Education honors the late Dr. Richard S. Laskin, a valued member of the HSS medical staff for 17 years, former Chief of the Division of Arthroplasty and former Editorin-Chief of the HSS Journal. The Laskin Chair supports two vital areas with which Dr. Laskin was intimately involved: the Arthroplasty Division Total Joint Registry and the HSS Journal. The Laskin Chair is currently held by Dr. Charles Cornell, Editor-in-Chief of the HSS Journal and Clinical Director of the Department of Orthopedic Surgery. The Laskin Chair ensures that Dr. Laskin’s legacy, especially exemplified by the HSS Journal, will live on at HSS in perpetuity.
DAVID B. LEVINE MD CHAIR IN SCOLIOSIS Frank Schwab, MD Dr. Frank Schwab, HSS Spine Service Chief, is a widely recognized leader in the field of spinal deformity care, with his clinical practice focusing on complex spinal pathology, adult and pediatric spinal deformity, scoliosis, and revision/reconstruction procedures. Dr. Schwab is focused on innovating patient-specific operative treatment, optimizing sagittal realignment guidelines, and using pre-operative planning technologies and techniques for complex spine surgery. In addition, he developed the first definitive classification of adult spinal deformity that has become a clinical standard for spinal surgeons worldwide. Dr. Schwab has published over 200 original and review articles, and has had more than 400 presentations at scientific conferences. He also serves on the boards of the International Spine Study Group and Scoliosis Research Society. Under his direction, the Levine Chair supports spine research at HSS.
C. RONALD MACKENZIE MD CHAIR IN ETHICS AND MEDICINE C. Ronald MacKenzie, MD The C. Ronald MacKenzie MD Chair in Ethics and Medicine benefits rheumatologist/ internist Dr. C. Ronald MacKenzie in his efforts to address ethical issues facing the chronically ill, specifically those with rheumatologic disease. Funds from the Chair have supported Dr. MacKenzie’s work with a number of ethics and clinical fellows and colleagues. These collaborations are advancing our understanding of issues related to chronic disease, as well as the ethical dilemmas facing modern medicine. Working in conjunction with colleagues at the American College of Rheumatology (ACR), Dr. MacKenzie spearheaded a survey of the College’s membership concerning ethical challenges in the profession that was published in the journal Arthritis & Rheumatology in 2013. Dr. MacKenzie is currently collaborating with Canadian investigators to examine how ethical problems differ in alternative models of health care delivery.
ENDOWED CHAIRS, PROFESSORSHIPS, AND FELLOWSHIPS 2016 7
2016 Endowed Chairs and Professorships
STEPHEN A. PAGET MD CHAIR IN RHEUMATOLOGY Stephen A. Paget, MD, FACP, MACR
LEON ROOT MD CHAIR IN PEDIATRIC ORTHOPAEDICS Roger F. Widmann, MD
The Stephen A. Paget MD Chair in Rheumatology honors Physician-in-Chief Emeritus and former Chairman of the Division of Rheumatology at HSS, Dr. Stephen Paget. As Chairman, Dr. Paget developed and ran a world-class rheumatology division of 46 physicians, scientists, and clinician-scholar educators. He has both national and international recognition as a Master Clinician in a broad range of systemic, inflammatory, and autoimmune disorders. As a noted clinician-scholar educator, he has had a significant impact upon rheumatology education at HSS and nationally, and is currently the Director of the HSS Rheumatology Academy of Medical Educators. Dr. Paget became a Master in the American College of Rheumatology in 2010 and received the organization’s ACR Distinguished Clinical Scholar Award in 2011.
Dr. Roger Widmann is Professor of Clinical Orthopaedic Surgery and Chief of the Pediatric Orthopaedic Surgery Service since 2004. He is an outstanding teacher, clinician, and surgeon who trained at the Harvard Orthopaedic Surgery Residency and Pediatric Orthopaedic Fellowship Programs under the exceptional team of John Hall, John Emans, and James Kasser. Having published over 50 peer-reviewed articles and multiple textbook chapters, Dr. Widmann is an expert pediatric spinal deformity surgeon with long-established clinical and research expertise in limb length discrepancy and limb deformity. He is a member of the Scoliosis Research Society, the Pediatric Orthopaedic Society of North America, and the Limb Lengthening and Reconstruction Society, where he serves on numerous committees. As service chief, Dr. Widmann led a collaborative effort to create and staff the Lerner Children’s Pavilion with nine highly regarded pediatric orthopaedic surgeons. With a focus on clinical and surgical excellence, academic productivity, and care for the under-served, the Lerner Children’s Pavilion is the largest provider of pediatric orthopaedic surgery in the tri-state area. The Root Chair supports the Pavilion’s ongoing critical mission of clinical care, research, and education.
CHITRANJAN S. RANAWAT MD CHAIR IN ADULT RECONSTRUCTION AND JOINT REPLACEMENT Douglas E. Padgett, MD Dr. Douglas Padgett, Chief of the Adult Reconstruction and Joint Replacement Service, works to ensure continued excellence and innovation in the ARJR Service. A renowned surgeon, educator, and researcher, Dr. Padgett trained under celebrated surgeons Dr. Chitranjan S. Ranawat, Dr. Philip D. Wilson, Jr., Dr. John Insall, and Dr. Jorge Galante. Dedicated to improving the design, delivery, and outcomes of joint replacements of the hip and knee, Dr. Padgett and his team are working with the Department of Biomechanics and the implant retrieval archive to better understand the failure mechanism of implants and make design changes that improve performance. They are also investigating the use of technologies such as computer-assisted navigation and robotics to more accurately implant prosthetic devices. As one of the largest institutional registries of its kind, the Total Joint Replacement Registry provides invaluable information on patient outcomes after joint replacement. The Ranawat Chair provides vital support for these and many other critical Service initiatives.
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VIRGINIA F. AND WILLIAM R. SALOMON CHAIR IN MUSCULOSKELETAL RESEARCH Carl Blobel, MD, PhD Dr. Carl Blobel, Director of the Hospital’s Arthritis and Tissue Degeneration Program, is a world leader in the study of metalloprotease-disintegrins, proteins that are important in inflammation, arthritis, blood vessel formation, cancer, and bone remodeling. Specifically, his research is focused on bench-to-bedside studies that illuminate the function and regulation of metalloprotease-disintegrins in the context of rheumatoid arthritis, osteoarthritis, and tissue degeneration and regeneration. By elucidating the underlying disease mechanisms, Dr. Blobel’s studies will play a key role in devising new targeted treatments for autoimmune and inflammatory illnesses.
2016 Endowed Chairs and Professorships
EDUARDO A. SALVATI MD CHAIR IN HIP ARTHROPLASTY Mathias P. Bostrom, MD
THE PETER JAY SHARP CHAIR IN LUPUS RESEARCH Alessandra Pernis, MD
Dr. Mathias Bostrom is an Attending Orthopaedic Surgeon and the Eduardo Salvati Professor of Orthopaedic Surgery at Weill Cornell Medical College. He is a specialist in hip and knee surgery, with expertise in complex reconstructions and the treatment of musculoskeletal infections. Dr. Bostrom’s research interests focus on the quality of bone healing, including bone biology, formation, regeneration, and osseointegration. He is the author of over 140 journal articles and book chapters, and is a member of numerous prestigious academic orthopedic societies, such as the American Academy of Orthopaedic Surgeons, American Orthopaedic Association, Hip Society, and International Society for Fracture Repair. Dr. Bostrom served as President of the Orthopaedic Research Society (ORS) from 2015-2016. He is also a member of several review panels, including the Musculoskeletal Tissue Engineering Study Section of the National Institutes of Health. In 2013, he was selected to be a Fellow in the American College of Surgeons. In 2014, he was appointed Chief of the Hip Service at HSS. The Salvati Chair supports research of the Hip Service at the direction of Dr. Bostrom.
The Peter Jay Sharp Chair in Lupus Research supports the research activities of Dr. Alessandra Pernis. Dr. Pernis is a Senior Scientist and a leader in the study of the mechanisms that regulate the development of Systemic Lupus Erythematosus. She employs both comparative models and translational approaches to delineate the molecular networks responsible for lymphocyte dysfunction in autoimmune diseases. Lymphocytes are important cells of the immune system that normally help fight pathogens. In autoimmune diseases, however, lymphocytes become deregulated and start attacking one’s own body. Dr. Pernis has identified key molecules that control the function of lymphocytes. Her recent studies have demonstrated that improper regulation of these molecules can lead to lupus and that deregulation in these molecules can be observed in SLE patients. The insights emerging from Dr. Pernis’ work are providing critical information for the development of novel therapeutic regimens for the treatment of SLE and other autoimmune diseases.
ST. GILES RESEARCH CHAIR THOMAS P. SCULCO MD CHAIR IN ORTHOPAEDIC SURGERY Thomas P. Sculco, MD Dr. Thomas Sculco is a recognized leader in total hip and knee replacement, having pioneered minimally invasive surgical techniques for total hip replacements, including the design of instruments for these procedures. Dr. Sculco is also the Surgeon-in-Chief Emeritus and the Director of the Complex Joint Reconstruction Center. Funds from the Sculco Chair support the Center’s efforts to conduct research to improve implant longevity, as well as coordinate expert care for the most complex cases of joint reconstruction. Dr. Sculco has written over 350 scientific articles, 83 chapters/books, and presented over 700 papers on orthopedic surgery and the surgical treatment of arthritis. He also has special expertise in implant wear and osteolysis, and thromboembolic disease.
The St. Giles Research Chair supports the research activities of Dr. Theresa Lu, Associate Scientist in the Autoimmunity and Inflammation Program. Dr. Lu is one of only about 200 pediatric rheumatologists in the U.S. and one of only a handful who conduct laboratory research. She heads the Lymphoid Tissue Organization and Function Laboratory, where researchers are investigating how blood vessels and fibroblasts of lymphoid tissues can control the immune cells. Harnessing this understanding may better control the unwanted autoimmune responses in diseases such as lupus and inflammatory arthritis. Dr. Lu’s work is leading to better treatments for scleroderma and has potential implications for bone and cartilage disorders. A past recipient of the Anne Kennedy O’Neil Research Fellowship Award for studies of autoimmune conditions that primarily affect women, Dr. Lu’s efforts promise to provide new ways to treat and delay the progression of autoimmune diseases that affect both children and adults. ENDOWED CHAIRS, PROFESSORSHIPS, AND FELLOWSHIPS 2016 9
2016 Endowed Chairs and Professorships
STARR CHAIR IN MINERALIZED TISSUE RESEARCH Adele L. Boskey, PhD Dr. Adele Boskey, Director of the Mineralized Tissue Laboratory and the Musculoskeletal Integrity Program, is a world-renowned scientist in the field of mineralized tissue research. A recipient of the Shands’ Award for lifelong contributions to orthopedic research, she was also named an Orthopaedic Research Society (ORS) Innovator and received the ORS-OREF Distinguished Investigator Award. Recently, Dr. Boskey received the Lawrence G. Raisz Award from the American Society for Bone and Mineral Research for her contributions to preclinical translational research in the bone and mineral field. She pioneered the use of infrared imaging for the analysis of bone and other mineralized tissues. Her laboratory is dedicated to understanding bone composition and structure in health and disease, with a particular focus on bone diseases like osteoporosis, osteogenesis imperfecta (brittle bone disease), and other skeletal dysplasias.
STARR CHAIR IN TISSUE ENGINEERING RESEARCH Dr. Chitra Dahia is an Assistant Scientist in the Tissue Engineering, Regeneration, and Repair Program. The Starr Chair in Tissue Engineering Research supports Dr. Dahia’s work, which is focused on preventing and better treating degenerative disc disease, a major cause of lower back pain. Using a mouse model system, Dr. Dahia has identified key pathways that are not only important to the growth and maintenance of a young and healthy disc, but can also be targeted to re-awaken an aging disc. Her long-term research goal is to develop potential therapeutic approaches to disc regeneration and treatment of lower back pain, using the same mechanism by which the disc normally forms, grows, and stays healthy.
RUSSELL F. WARREN RESEARCH CHAIR The Russell F. Warren Research Chair honors Surgeon-inChief Emeritus Dr. Russell Warren. Funds from the Chair support the work of Associate Scientist Suzanne Maher, PhD. Dr. Maher has focused her research on designing and evaluating hydrogels, variable synthetic water-based materials, for the purposes of resurfacing damaged joints. In addition, the function and replacement of menisci have been studied in detail. By developing new biomaterials to restore damaged joint tissues, Dr. Maher’s work promises to help prevent or slow the development of osteoarthritis.
Selected Accomplishments of Endowed Chairs and Fellowships AUTOIMMUNE AND INFLAMMATORY DISEASES: Identified a potential genetic trigger linked to the development of the autoimmune diseases lupus and Sjogren’s syndrome, providing the potential for new and better treatments. Described functional subsets of lymphocytes that play a role in the heterogeneity of autoimmune diseases such as SLE and RA, and which may serve as targets for therapeutics. BIOMECHANICS: Demonstrated that surgical reconstruction of the anterior cruciate ligament (ACL)-injured knee does not need to include the costly and timeconsuming anterolateral ligament (ALL) reconstruction, which has recently become part of many ACL reconstruction procedures. LUPUS: Identified a regulator of two major cellular pathways involved in autoimmune disease that provides a target for treating both lupus and RA. ORTHOPEDICS: Developed an MRI-compatible novel loading device that enables quantification of cartilage deformation, ultrastructure and material properties under loading conditions, and predicts predisposition for further joint degeneration, which may enable early intervention to prevent or slow the onset of osteoarthritis. RHEUMATOID ARTHRITIS: Identified a regulator of immune responses in inflammatory diseases such as RA that may provide therapeutic targets to help reverse inflammatory bone loss. TISSUE REPAIR: Developed a model for tissue regeneration and repair using the intrinsic stem cell population in orthopedic soft tissues. This model promises to help advance the development of more effective treatments that harness the body’s own healing capacity.
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Jane E. Salmon, MD, Collette Kean Research Chair; and Carl Blobel, MD, PhD, Virginia F. and William R. Salomon Chair in Musculoskeletal Research ENDOWED CHAIRS, PROFESSORSHIPS, AND FELLOWSHIPS 2016 11
2016 Endowed Fellowships ROBERT AND HELEN APPEL FELLOWSHIP IN BIOMEDICAL ENGINEERING Natalie Kelly
IRA W. DECAMP FELLOWSHIP IN MUSCULOSKELETAL GENETICS Mar y Goldring, PhD
The Robert and Helen Appel Fellowship in Biomedical Engineering enhances training opportunities at HSS for Cornell University graduate students and postdoctoral fellows. Natalie Kelly, previously a research engineer in the Department of Biomechanics at HSS, is now a graduate student who studies the molecular mechanisms responsible for increased bone mass in response to mechanical loading. This research may identify new therapeutic targets for the treatment of osteoporosis, a disease characterized by bone loss.
Dr. Mary Goldring, Senior Scientist, Co-Director of the Tissue Engineering, Regeneration, and Repair Program at HSS, and Professor of Cell and Developmental Biology at Weill Cornell Medical College, is a leading scientist in the area of cartilage biology and gene regulation. Her studies are helping to define the molecular and cellular mechanisms that lead to alterations in the remodeling of cartilage in osteoarthritis using mouse models and clinical biospecimens. By contributing to a better understanding of the critical inflammatory and stress signals involved in cartilage degradation and defective repair at different stages of the disease, Dr. Goldring’s work promises to lead to the development of new targeted therapies. Previously, Dr. Goldring served as President of the Orthopaedic Research Society (ORS).
FINN AND BARBARA CASPERSEN FELLOWSHIP FOR SPINE RESEARCH Samuel Z. Grinberg Samuel Grinberg is a researcher in the Integrated Spine Research Program at HSS. He is investigating the use of intravenous acetaminophen before and after lumbar spinal fusion surgery as part of a randomized prospective study. The goal of his research is to reduce postoperative pain, opioid use, and length of stay in the hospital while improving recovery.
CHARLES L. CHRISTIAN RESEARCH FELLOWSHIP Marie-Dominique Ah Kioon, PhD Dr. Marie-Dominique Ah Kioon is a post-doctoral fellow in the Autoimmunity and Inflammation Research program, researching the biology of the immune system’s plasmacytoid dendritic cells (PDC) and their involvement in Systemic Sclerosis. Dr. Ah Kioon is studying the molecular and cellular mechanisms underlying PDC function in immunity and how these cells can be manipulated for the benefit of patients. Her work aims to develop new ways to target these cells and reduce their pathological role in Systemic Sclerosis.
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LEO FARBMAN FELLOWSHIP FOR PEDIATRIC MUSCULOSKELETAL RESEARCH Lorene C. Janowski, DPS, OTR/L, MS, C/NDT Lorene C. Janowski is an occupational therapist at HSS’ Children and Adolescent Hand and Arm (CHArm) Center, dedicated to the treatment, research, and education of children and adolescents living with disorders of the upper extremities. By collaborating with pediatric orthopedic surgeons and reviewing assessments and video analysis, Ms. Janowski helps to ensure that patients’ surgical procedures are complemented by appropriate rehabilitative techniques. She is trained in Neurodevelopmental Treatment (NDT) for children and uses these techniques to help improve the quality of life and function for children with neuromuscular disorders, such as cerebral palsy.
2016 Endowed Fellowships
KEN AND JILL ISCOL FELLOWSHIP IN ORTHOPAEDIC RESEARCH Andrew D. Pearle, MD Dr. Andrew Pearle is an orthopedic surgeon specializing in sports medicine. His clinical interests include arthroscopic and computer-aided surgery of the shoulder, knee, and ankle. He founded and developed the HSS Computer Assisted Surgery Center, one of the first of its kind in the U.S., and continues to serve as the program’s Clinical Director. By enabling surgeons to measure with pinpoint precision the angle and alignment of repair (in a 3-dimensional field) at each surgical step, computerassisted surgery enhances the surgeon’s ability to draw meaningful conclusions regarding the healing process and the consequences of the repair.
HELEN FRANKENTHALER FELLOWSHIP IN RESTORATIVE MOBILITY Andrew D. Pearle, MD The Helen Frankenthaler Fellowship in Restorative Mobility, held by Dr. Andrew Pearle (pictured above), supports the training of surgeons in the principles and techniques of Computer Assisted Surgery (CAS). The CAS lab is a simulated digital operating room with navigation and robotic systems and provides an environment for research and development in surgical navigation and medical robotics in orthopedic surgery.
MARY RODGERS AND HENRY GUETTEL FELLOWSHIP IN BIOMEDICAL MECHANICS Christina Esposito, PhD The Mary Rodgers and Henry Guettel Fellowship in Biomedical Mechanics enables medical students and postdoctoral fellows to pursue research on the biomechanics of the musculoskeletal system under the mentorship of experienced scientists and physicians. Postdoctoral fellow Christina Esposito specializes in implant retrieval analysis of joint replacements and periprosthetic tissue reactions to wear debris. Under the supervision of Dr. Timothy Wright, Dr. Esposito is developing patientspecific plans for hip and knee component placement using new imaging and navigation technologies.
MICHAEL D. LOCKSHIN FELLOWSHIP OF THE BARBARA VOLCKER CENTER FOR WOMEN AND RHEUMATIC DISEASE Xiaoping Qing, MD, PhD Dr. Xiaoping Qing is a research instructor in the Autoimmunity and Inflammation Research Program at HSS, working in the laboratory of Dr. Jane Salmon. Dr. Qing seeks to expand our understanding of how and why women are more likely to develop lupus. The Michael D. Lockshin Fellowship, funded by the generosity of the Volcker family, supports her research on lupus nephritis. Dr. Qing will examine how estrogen affects the activation of the iRhom2/ADAM17 pathway (genes that play a significant role in inflammatory immune response), and how this pathway contributes to the development of lupus nephritis in women. She has published several research articles in peer-reviewed immunology journals and has presented her work at international scientific meetings. In 2010, she was a recipient of the SLE Lupus Foundation’s Fellowship Award.
Shanthini Kasturi, MD, MSc Dr. Shanthini Kasturi is a rheumatologist with an interest in the use of patient reported outcome measures to improve clinical care of rheumatic diseases. The Michael D. Lockshin Fellowship supports her research on the use of Patient Reported Outcomes Measurement Information System (PROMIS) questionnaires to assess the quality of life for patients with systemic lupus erythematosus. Dr. Kasturi is validating PROMIS computerized adaptive tests in patients with lupus and will investigate how the clinical integration of these surveys can facilitate patient engagement and the provision of patient-centered care. She is a recipient of the Rheumatology Research Foundation’s Scientist Development Award.
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2016 Endowed Fellowships
IRVING AND SALLY LIPSTOCK FELLOWSHIP IN ORTHOPEDIC SURGERY Alberto Carli, MD Under the guidance of Dr. Mathias Bostrom, Dr. Alberto Carli is pursuing important fundamental research in the Arthroplasty Research Laboratory at HSS. He has developed a novel animal model of periprosthetic joint infection that is the most clinically representative and methodologically rigorous to date. Through this work, Dr. Carli aims to clarify the precise mechanism by which bacteria adhere to metal in-vivo and maintain their presence around an artificial joint. He has also begun to elucidate why current clinical treatments sometimes fail and is evaluating novel antibiotics, which, if found to be more effective, could find their way into clinical practice.
LUDWIG FELLOWSHIP FOR WOMEN’S SPORTS MEDICINE RESEARCH Elizabeth Selvaggio The Ludwig Fellowship for Women’s Sports Medicine Research is a 24-month clinical research fellowship that provides funding for an individual interested in medical and orthopedic issues in Women’s Sports Medicine. The fellow has exposure to surgical and clinical treatment of active women at an interdisciplinary sports medicine center, and has the opportunity to work with orthopedic surgeons, primary care sports medicine specialists, physical therapists, nutritionists, and an exercise physiologist. As the Ludwig Fellow, Elizabeth Selvaggio is working on a study regarding the relationship between lower limb musculoskeletal injuries (which may or may not require surgery) and Vitamin D insufficiency and deficiency. She is also helping with a project that will test the reliability of specific qualitative movement assessments used to assist athletes in determining when to return to their primary sport following ACL reconstruction.
14 ADVANCING THE FRONTIERS OF MEDICINE
STAVROS NIARCHOS FOUNDATION-THOMAS P. SCULCO MD INTERNATIONAL ORTHOPAEDIC FELLOWSHIP Vasileios Soranoglou, MD, PhD, FEBOT Dr. Vasileios Soranoglou is a Greek orthopedic surgeon interested in joint replacement surgery. He is pursuing a number of clinical research projects under the supervision of HSS Surgeon-in-Chief Emeritus Dr. Thomas Sculco. His main research field is blood management strategies in bilateral total knee arthroplasty. He is analyzing predictive factors for transfusion and techniques to reduce blood loss. In addition, Dr. Soranoglou is studying the survivorship and failure mechanisms of constrained implants in total hip replacement surgery. Currently, he is working on two review studies investigating the use of stemless constrained condylar knee and dual mobility implants in total knee and total hip replacement surgery, respectively.
ROBERT AND GILLIAN STEEL FELLOWSHIP IN MUSCULOSKELETAL RESEARCH Inez Rogatsky, PhD Dr. Inez Rogatsky heads the Laboratory of Steroid Hormone Receptors and Inflammation. Her studies aim to improve glucocorticoid steroids, frontline drugs used to combat autoimmune and inflammatory diseases. Dr. Rogatsky is exploring the molecular mechanisms by which glucocorticoid steroids act on the immune system. Understanding this interaction may enable scientists to selectively channel glucocorticoids exclusively to the specific inflammatory cells of the immune system while sparing other cell types so that excessive exposure to these drugs no longer causes harmful side effects, such as metabolic syndrome, type II diabetes, osteoporosis, muscular dystrophy, and vascular hypertension. In 2013, Dr. Rogatsky received the first Anne Kennedy O’Neil Research Fellowship Award to explore the impact of treatment for autoimmune conditions primarily affecting women. In 2014, Dr. Rogatsky was awarded two federal grants from the National Institutes of Health and the Department of Defense, as well as a grant from the Rheumatology Research Foundation.
2016 Endowed Fellowships
NANCY DICKERSON WHITEHEAD RESEARCH FELLOWSHIP Miguel Otero, PhD
IMMUNOLOGY AND INFLAMMATION FELLOWSHIP Sergei Rudchenko, PhD
Dr. Miguel Otero is an Assistant Scientist in the Tissue Engineering Regeneration and Repair Program, where he is studying altered signaling pathways that prompt joint tissue disruption in osteoarthritis. The goal of his work is to understand how joint tissues respond to pathologic stimuli and how their altered functions contribute to osteoarthritic disease. Ultimately, Dr. Otero’s work aims to develop new models to study the early stages of osteoarthritis, and to explore the implementation of targeted therapeutic approaches.
The Immunology and Inflammation Fellowship provides funding for basic and translational research defining the mechanisms involved in autoimmune and inflammatory diseases. With a focus on understanding how tissue damage and repair are regulated in orthopedic and rheumatologic conditions, novel approaches are being developed for therapeutic interventions to prevent tissue damage and maintain patient mobility. Dr. Sergei Rudchenko, a biophysicist, is focusing on cell-targeting using molecular computing. By developing the ability to eliminate very narrow subpopulations of cells using molecular automata, Dr. Rudchenko hopes to address questions related to the mechanisms of rheumatologic diseases and at the same time to ameliorate them.
FELLOWSHIP IN ARTHROPLASTY Edward Purdue, PhD Dr. Edward Purdue is an Associate Research Scientist and Director of the Osteolysis Research Laboratory, where he is studying the cellular and molecular mechanisms underlying bone loss, or periprosthetic osteolysis, which causes joint implant loosening and is one of the major reasons for revision surgery. Studies in his laboratory focus on how particles generated from the prostheses or bone cement around joint replacements affect the cells in the immediate environment, some of which are involved in regulating inflammation. The goal of this work is to gain an improved understanding of osteolysis so that methods can be developed to prevent or interrupt the cascade of events leading to bone destruction, thereby extending the life of joint implants.
About Hospital for Special Surgery Founded in 1863, Hospital for Special Surgery (HSS) is a world leader in orthopedics, rheumatology, and rehabilitation. HSS is nationally ranked No. 1 in orthopedics, No. 2 in rheumatology by U.S. News & World Report (2016-2017) and has been among the top-ranked hospitals for orthopedics and rheumatology for 25 consecutive years. HSS was the first hospital in New York City to receive the Magnet Award for Nursing Excellence and the first Hospital in the State of New York to be re-designated with Nursing’s highest honor four consecutive times, and has one of the lowest infection rates in the country. The Hospital’s research division is internationally recognized as a leader in the investigation of orthopedic, rheumatologic, and related autoimmune diseases, discovering and developing effective, novel approaches for prevention, diagnosis, and treatment of these conditions. HSS is a member of the NewYork-Presbyterian Healthcare System and an affiliate of Weill Cornell Medical College, where Hospital for Special Surgery medical staff serve on the faculty.
ENDOWED CHAIRS, PROFESSORSHIPS, AND FELLOWSHIPS 2016 15
Officers and Board Members
(As of August 2016)
Board of Trustees
Chair Kendrick R. Wilson III
Todd J. Albert, MD James M. Benson Daniel C. Benton Herbert Black Michael C. Brooks Kathryn Chenault Charles P. Coleman III Charles N. Cornell, MD Leslie Cornfeld Mary K. Crow, MD Cynthia Foster Curry Barrie M. Damson James G. Dinan Anne Ehrenkranz Michael Esposito Marina Kellen French Steven B. Haas, MD David L. Helfet, MD Robert N. Hotchkiss, MD Lionel B. Ivashkiv, MD Craig S. Ivey Winfield P. Jones Warren B. Kanders Monica Keany Bryan T. Kelly, MD Thomas J. Kelly, MD, PhD David H. Koch Laurie Hodges Lapeyre Pablo Legorreta Lara R. Lerner Kathy Leventhal Marylin B. Levitt Thomas Lister Alan S. MacDonald Richard L. Menschel Dean R. O’Hare Terry O’Toole Aldo Papone Gordon B. Pattee Steven Rattner Susan W. Rose Thomas P. Sculco, MD
Vice Chairs Michael Esposito Thomas Lister Deirdre Stanley President and Chief Executive Officer Louis A. Shapiro Surgeon-in-Chief and Medical Director Todd J. Albert, MD Executive Vice President Lisa A. Goldstein Executive Vice President and Treasurer Stacey L. Malakoff Executive Vice President, Chief Legal Officer, and Secretary Irene Koch, Esq. Chairmen, Emeriti Richard L. Menschel Dean R. O’Hare Aldo Papone
Hospital for Special Surgery is an affiliate of Weill Cornell Medical College.
535 East 70th Street New York NY 10021
Louis A. Shapiro Jonathan Sobel Deirdre Stanley Robert K. Steel Patricia G. Warner Sanford I. Weill Kendrick R. Wilson III Ellen M. Wright Robert D. Yaffa
Life Trustees Loring Catlin Kathryn O. Greenberg James R. Houghton Carl B. Menges Samuel S. Polk Charlton Reynders, Jr. Katherine O. Roberts Donald Stone Russell F. Warren, MD Torsten N. Wiesel, MD Mrs. Ezra K. Zilkha
Board of Advisors Chair Robert D. Yaffa Vice Chair Katherine Doerge Founding Member Kenneth V. Handal Bradley Amoils Barry L. Bloom Peter L. Briger, Jr. Jeffrey B. Citrin Mary Ann Deignan Katherine Doerge John B. Ehrenkranz Sanford B. Ehrenkranz Stephan Feldgoise Marc Gabelli Cynthia Golub Lorna B. Goodman
Rachel Grodzinsky Kenneth V. Handal Henry U. Harris III Holly Johnson, MD Kurt Johnson Maria Ines Kavamura, MD, PhD Sandra Kozlowski Matthew F. LeBaron David M. Madden David H. McCormick Stephen C. Mills Connie Anne Phillips Rick Rieder Douglas L. Sacks Kenneth Shubin Stein, MD Tad Smith Robert D. Yaffa Advisor Emeritus Earl G. Graves, Sr.
International Advisor y Council Chair David H. McCormick Todd J. Albert, MD Mathias P. Bostrom, MD Karen Cook Andreas C. Dracopoulos Katharine Eltz-Aulitzky Marc Gabelli Maria Ines Kavamura, MD, PhD Henry A. Kissinger David K. Li Richard L. Menschel Chitranjan S. Ranawat, MD Rick Rieder Benjamin M. Rosen Thomas P. Sculco, MD Louis A. Shapiro Paul A. Volcker Torsten N. Wiesel