2021 ANNUAL REPORT
CONTENTS HOWDY 3 MISSION & HISTORY 4 FACILITIES 6 RESEARCH ENTITIES IN HCRF 7 ADMINISTRATION 8 RESIDENT-PI'S 9 BOARD OF DIRECTORS 12 BOARD MEMBERSHIP 14 CONDUCTING RESEARCH IN HCRF 16 INITIATING PROJECTS IN HCRF 17 COLLABORATING FACULTY 18 HUMAN CORE SERVICES 20 ANALYTICAL SERVICES 22 SERVICE RATES 24 BUDGET & RESOURCES 28 BY THE NUMBERS 30 NEWS AND INITIATIVES 32 SPONSORS 36 FUNDED CLINICAL TRIALS 38 SERVICE PROJECTS 38 GRANTS & CONTRACTS 43 2021 PUBLICATIONS 50 MARKETING 52 675 Kimbrough Blvd Building #1542 TAMU 4253 College Station, TX 78843 979 458 1498 hcrf@tamu edu hcrf tamu edu /tamuclinicalresearch/ /HCRF3 CREDITS College of Education & Human Development Research & Development Office Michael de Miranda, PhD, Interim Dean College of Education & Human Development Jeff Liew, PhD Associate Dean for Research College of Education & Human Development Richard B Kreider, PhD, FACSM, FISSN, FACN, FNAK Executive Director Author & Editor of Annual Report JP Bramhall, MD Medical Director 2
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TRANSFORMING HUMAN BIOMEDICAL RESEARCH AT TEXASA&M UNIVERSITY
On behalf of the College of Education and Human Development's Research & Development Office, I would like to welcome you to our 2021 Human Clinical Research Facility (HCRF) Annual Report. This report provides an overview of efforts made over the last year to develop the HCRF into a campus-wide core facility for conducting human clinical research at Texas A&M University.
Despite COVID-19 related challenges and discussions about how management realignment at TAMU may affect HCRF operations, we experienced another record year in assisting faculty and external sponsors in conducting research at the HCRF through collaborating on grant projects and conducting fee for service (FFS) testing to support their research. We have seen a tremendous increase in the number of projects that independent principal investigators (PI's) and external sponsors want conducted by research staff particularly in the Exercise & Sport Nutrition Lab (ESNL). Additionally, we had an exceptional year in working with faculty to submit grants, obtaining IRB approval to launch externally funded grants and fee for service projects, establishing the HCRF as a university core research facility, engaging in university core facility activities, improving administrative and billing processes, and nearly completing the Aerospace Engineering human centrifuge facility These efforts have certainly help move the university forward in conducting human biomedical research into the future
Richard B. Kreider, PhD, FACSM, FISSN, FACN, FNAK Executive Director
HOWDY
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HISTORY MISSION
Toserveasacomprehensiveb provid l researchatTexasA&MUniversity.
ingsupporttoresearchersconductinghumanclinica
iomedicalresearchfacilityin
Efforts to develop the Human Clinical Research Facility (HCRF) began in 2008 when Dr. Kreider relocated the Exercise & Sport Nutrition Lab (ESNL) to Texas A&M University (TAMU) to become Head of the Department of Health & Kinesiology (HLKN) in the College of Education and Human Development (CEHD) Because facilities supporting human clinical research were limited at TAMU, the ESNL was located in the Research Park where they paid rent for a 5,000 sf ft facility In 2008 09, efforts began to pursue development of a human biomedical research facility to house the ESNL and other related labs in HLKN The university supported submission of an NIH C06 facility grant to build a Human Biomedical Research Building to house the ESNL and other HLKN basic and applied labs The proposal was favorably scored but not funded. Around this time, the university had a call for white papers to help develop major research themes. Submissions included research themes related to genomics, obesity, aging, and translational research. As part of this effort, the CEHD decided to support a signature hire in aging. This facilitated the recruitment of Dr. Nicolaas Deutz and his research team from the University of Arkansas for Medical Sciences to develop the Center for Translational Research in Aging and Longevity (CTRAL) This effort led to development of CTRAL next to the ESNL in the Research Park As a result, there was greater interest in helping other faculty members conduct their 4
5 research protocols in the ESNL and/or CTRAL facilities. In 2013, there was a call to Deans for high impact ideas Consequently, Dr Doug Palmer, Dean of the CEHD, Dr Rick Kreider (Head of the Department of Health & Kinesiology at the time), and Dr Nicolaas Deutz (Director of CTRAL) submitted a proposal to add another 10,000 sq ft to the Research Park facility so they could work with additional faculty on their projects While this proposal was well received, the university did not want to invest in a building not owned by the university So they asked for an estimate to build the HCRF and efforts began to make the HCRF a reality The university invested about $10 5 million dollars to support this effort with remaining funds supported by the CEHD and HLKN (about $3 million dollars) After several years of planning and construction, the HCRFofficially opened on April 11, 2017. In 2019, the CEHD partnered with Aerospace Engineering to plan building an annex ($1.5 million dollars) to the HCRF to house a short-radius human centrifuge previously located at UTMB-Galveston to conduct NASA-related anti-gravity research. Construction began in the winter of 2020 and with plans to be operational by summer of 2021 Since the summer of 2017, the HCRFhas served as a primary hub for conducting human biomedical research at TAMU As part of TAMU's realignment efforts, the HCRFwill be transferred from the CEHD to the Texas A&M Health Sciences Center beginning September 1, 2022
- Exercise and Rehabilitation & Training Facilities - Conference / Lecture Area Offices for Faculty, Staff, and Research Associates - Data Storage Area - 12 Beds for Overnight Research Studies - Metabolic Kitchen Physiological Testing (Isokinetic, Balance, Metabolic, Anaerobic) - DEXA Body Composition & Bone Density Room - Resting Energy Expenditure Room - Medical Exam & Procedure Rooms (4) Compounding Facility to Prepare Solution for Infusions/Injections - Sample Prep Room - Freezer Room / Biobank - Comprehensive Wet Lab Facilities with 6 Mass Specs Short Radius Human Centrifuge FACILITIES 6
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Thus, theservicecenter isonly one component of theoverall research activity within theHCRF and impact toTAMU. Human Centrifuge Facility
Thecenter and labshoused in the HCRF work asindependent entitiesunder thedirection of their directorsjust likeother PI's allocated spacein other buildings on campus. They obtain their own funding toconduct their research and support their staff. They are availabletocollaboratewith faculty and sponsorson research projectsand grantsof mutual interest.
CENTER LABS Core Facilit y Service Cent er ITIESINHCRF
TheHCRF alsooperatesasa core facility servicecenter. Faculty not housed in theHCRF can work with theHCRF Directorsand contributing center/lab director PI's tocollect data for them on their independent research on a feefor servicebasis. In doing so, the resident PI'sstaff involved in collecting data arereimbursed for their timeand effort from university approved feefor servicerates.
*The ATRML was housed in the HRCFin 2021 but Dr. Sheffield left the university in the spring of 2022 and the lab will no longer be housed in the HCRFeffective 6/1/22
RESEARCHENT
Ryan Sowinski, PhD serves Research Associate for FFStesting He earned his PhD in Nutrition and Food Sciences in 2019 and worked as a doctoral research graduate assistant in the ESNL since 2015 Dr Sowinski works with Mr Rasmussen in coordinating and overseeing data collection on FFS projects commissioned by faculty and/or external sponsors He has extensive experience in collecting human biomedical data, nutritional analysis, phlebotomy and biochemistry techniques, and statistical analyses Data collection is primarily coordinated by supervised doctoral students typically studying exercise physiology and/or nutrition. Approximately 10 12 doctoral students are generally available to work on service projects
DARLENEWHYTE HCRFPROGRAMCOORDINATOR
ICHARDB
Dr Kreider serves as Executive Director of the Human Clinical Research Facility His primary duties include:
Mr Rasmussen serves as Research Associate and Lab Coordinator for the ESNL He also coordinates fee for service studies conducted in the HCRF for faculty and external sponsors Prior to his time at Texas A&M, he served in similar capacities at the University of Memphis (1998 2002) and Baylor University (2002 2008). He received his bachelor?s degree from Kansas University and master?s degree from the University of Memphis Chris coordinates all fee for service and grant related research studies conducted by the ESNL Primary responsibilities include preparation and submission of IRB materials, staff training,test scheduling and testing, study quality assurance, maintenance of study records, and research compliance on fee for service projects
Mrs Darlene Whyte joined he HCRF staff the summer of 2019 as program coordinator for the HCRF fee for service program She holds a bachelor's of business administration from Dowling College and holds alternative teaching certification in business Mrs Whyte has over 15 years experience serving as a senior buyer for Federated Department Store, sales account executive for Liz Claiborne, and senior area sales manager for Dillard's Department Store. Since 2006, she served as a field trip specialist/special needs router for Comal ISD.
Mrs Whyte's duties include coordinating facility repair and maintenance, scheduling meetings and events, submitting purchasing requests, processing invoices for clients, and managing budget resources among other responsibilities CHRISRASMUSSEN,MS,MX,CSCS,EPC
R .KREIDER,PHD,FACSM,FISSN,FACN,FNAK
ADMINISTRATION 9
Representing the HCRFat meetings with the university administration as needed; Providing facility support for faculty assigned space, renting space, collaborating with resident PI?s, and/or commissioning fee for service testing on their independent research; Managing day to day operation of the HCRF including approval of HCRF related general expenses; Assisting faculty in gaining access and efficiently using the HCRF to conduct research if allocated use of space in the HCRF, renting space in the HCRF, referring potential collaborators to directors of the center / labs housed in the HCRF for collaboration on projects of mutual interest, and/or providing an estimate and conducting FFS testing; Ensuring all personnel working in the HCRF undergo and maintain necessary university training and maintain confidentiality of all testing results; Coordinate FFStesting services with PI?s in the HCRF; Ensure FFSservices are properly billed on a monthly basis and resources generated are credited to the personnel and labs involved in conducting the services; Advertising, marketing, and increasing engagement of the HCRFfor fee for service research activities including maintaining a comprehensive and up to date website that describes ways faculty and/or sponsors can conduct research in the HCRF and increase the impact of the HCRF on advancing human clinical research at TAMU; Organizing and chairing staff meetings; Organizing and overseeing annual fee for service rate study activities; Scheduling, setting the agenda, and chairing BOD meetings; Preparing BOD meeting and annual reports for the BOD; Assisting faculty and/or sponsors interested in conducting research in the HCRF on submission of federal, state, and/or private grant proposals; Assisting faculty in conducting their research in the HCRF as needed; and, Helping grow the federal, state, and privately funded human clinical trial grant footprint at Texas A&M
RESEARCHASSOCIATE&ESNLLABCOORDINATOR
RESEARCHASSOCIATES&DOCTORALSTUDENTS
EXECUTIVEDIRECTOR
BONNIEDUNBAR,PHD
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Dr Nicolaas Deutz, MD, PhD currently serves as Director for the Center for Translational Research in Aging and Longevity (CTRAL) For more than 30 years, his research background and expertise focus on nutrition, metabolism, and physiology studies involving the use of stable isotope methodologies, both in humans and animals According to Google Scholar, According to Google Scholar, Dr Deutz has published over 320 peer reviewed publications, been cited over 23,300 times in the literature, has an H index of 80 and an i10 index of 299 He is the Editor in Chief of the journal "Clinical Nutrition" with an impact factor of 6 770 Dr Deutz has received more than 27 million dollars in life time external funding from NIH, NSF, and industry. Dr. Deutz has extensive experience with isotopic calculations, validation and data interpretation The stable isotope approaches are used in several studies to unravel the metabolic changes in patients with chronic diseases (i e , chronic obstructive pulmonary disease, cancer, cystic fibrosis, chronic heart failure, obstructive sleep apnea, mild cognitive impairment and dementia, autism spectrum disorder) This research leads to new insights in protein and amino acid kinetics in subjects with chronic disease and resulted in specific recommendations to nutritional supplements as method for reducing muscle wasting.
RESIDENTPRINCIPALINVEST
IAZART
Dr Dunbar is a retired NASA astronaut, engineer and educator, currently with Texas A&M Engineering as a Texas A&M Engineering Experiment Station (TEES) Distinguished Research Professor in the Department of Aerospace Engineering. She also has a joint appointment as the Director of the TEES Institute for Engineering Education and Innovation (IEEI), and serves as director of theAerospace Human Systems Laboratory Dunbar, who is a member of the prestigious National Academy of Engineering, came to Texas A&M from the University of Houston where she was an M D Anderson Professor of Mechanical Engineering There she provided leadership in the development of a new integrated university science, technology, engineering and mathematics (STEM) center and was director of the Science and Engineering Fair of Houston She also directed the Sasakawa International Center for Space Architecture?s Space Architecture and Aerospace graduate programs She has devoted her life to furthering engineering, engineering education and the pursuit of human space exploration
Dr Artiles serves as an Assistant Professor in the Department of Aerospace Engineering at Texas A&M University Dr Artiles completed her PhD in Aeronautics and Astronautics at the Massachusetts Institute of Technology Her research interests include human performance in aerospace environments, artificial gravity and space countermeasures, exercise physiology, and human sensimotor function Dr Artiles will manage the Human Centrifuge Annex facility that is being built adjacent to the HCRF She has been awarded several internal grants to suppor this work. According to Google Scholar, she has published 20 articles, been cited about 145 times in the literature, and has an h index of 7 (i10 index 5)
MARIELLEENGELEN,PHD IGATORS
ANAD ILES,PHD
NICOLAASE.DEUTZ,MD,PHD
Education: Dr. Deutz obtained his MD and PhD at the University of Amsterdam, The Netherlands He is a medical physiologist and Nutrition Physician Specialist In 2019, Dr Deutz was honored with a University Level Association of Former Students Distinguished Achievement award for research Dr Marielle Engelen, PhD serves as Professor, Co Director, and Head of Clinical Research for the Center for CTRAL Her research focuses on the metabolic alterations underlying involuntary weight loss and muscle wasting in chronic inflammatory diseases, involving the use of stable isotope methodologies, and the effects of dietary modulation and exercise intervention to restore metabolism and physical performance in these patients As such, she has conducted and supervised many acute studies and coordinating human clinical trials, examining the effects of protein and amino acid intervention in healthy elderly and in those with chronic wasting diseases (i e , chronic obstructive pulmonary disease, cancer, cystic fibrosis, chronic heart failure, obstructive sleep apnea, cognitive impairment) She also has the expertise in methodology and techniques to examine body composition, muscle function, physical performance, gut and cognitive function, and well being According to Google Scholar, Dr Engelen has been cited over 9,000 times and has an h index of 41 (i10 index 66) She currently has several federally funded grants and contracts
Dr Kreider serves as Professor and Director of the Exercise & Sport Nutrition Lab at Texas A&M University He served as Head of the Department of Health & Kinesiology and Thomas A and Joan Read Endowed Chair for Disadvantaged Youth (2008 to 2017). Dr. Kreider has conducted numerous studies on nutrition and exercise and has published 6 books and over 240 peer reviewed articles and book chapters According to Google Scholar, his work has been cited over 18,200 tims (h index 70, i10 index 163) Dr Kreider is a Fellow of the American College of Sport Medicine (FACSM); a co founder, board member, and Fellow of the International Society of Sports Nutrition (FISSN); founding Editor In Chief of the Journal of the International Society of Sports Nutrition (IF 5 15); Fellow of the American College of Nutrition (FACN); former Board Member of the American Kinesiology Association (AKA); elected Fellow of the National Academy of Kinesiology (FNAK, #568); member of the American Public Health Association (APHA); and, member of the American Educational Research Association (AERA) Dr Kreider has received over 25 million dollars as a PI, Co PI and/or consultant in internal and/or external funding to support research related to the role of exercise and nutrition on health, disease, rehabilitation, performance, and/or health disparities/equity Dr Kreider has received the NSCA Nutrition Achievement Award (2010), Global Health & Pharma Sport & Nutrition Award (2017), and the ISSN Lifetime Achievement Award (2018) among others Dr Kreider has been a featured speaker at numerous conferences internationally and serves as a scientific consultant for industry and national
Dr ten Have serves as a Research Assistant Professor and Director of Preclinical Studies and Co Director of the Analytical Laboratory in CTRAL She earned her doctorate in Preclinical Nutrition at the University of Maastricht in The Netherlands and has expertise in both animal and human metabolism related clinical trials Dr ten Have has published over 30 peer reviewed articles According to Google Scholar, her work has been cited over 1,200 times and has an h index of 19 (i10 index 23) She currently is working on an internally funded grant and supports a number of other funded projects being conducted in CTRAL
TRAYWRIGHT,PHD
Dr Wright serves as a Research Assistant Professor in the Department of Health & Kinesiology and research associate to the ATM He completed his doctorate of philosophy degree in Wildlife and Fisheries Science at Texas A&M University and served as a post doc in Dr Sheffield Moore's lab at UTMB before moving to Texas A&M University Dr Wright has served as PI on an internal and foundation grant According to Google Scholar, he has published 18 articles, been cited 163 times in the literature, and has an h index of 7 (i10 index 7) Dr Wright left the university in May of 2022.
INDASHEFF
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Dr Sheffield Moore currently serves as Professor of Health & Kinesiology and Director of the Aging and Translational Research in Medicine Lab (ATM) She will be stepping down from this role this summer to focus on her research. For 20 years, Dr. Sheffield Moore worked at UTMB Galveston in the Department of Internal Medicine. During her time at UTMB, she has held a number of leadership roles including serving as the director of the Translational Technologies Key Resource for the Institute of Translational Sciences and a program director of the Institute of Translational Sciences Clinical Research Center Dr Sheffield Moore has been continuously funded by the National Institutes of Aging, National Cancer Institute, NASA, and through foundation grants to support her human clinical research program in areas of aging, cancer and traumatic brain injury According to Google Scholar, Dr Sheffield Moore has been cited over 12,000 times and has an h index of 46 (i10 index 79) She is currently working on projects with UTMB funded by the Moody Foundation Dr Moore moved back to UTMB in the spring of 2022
MEL IELD-MOORE,PHD
RICHARDB.KREIDER,PHD,FACSM,FISSN,FACN ,FNAK Contact Resident PI'sdirectlyif you areinterested in collaborating on research proposalsand/or grants.
GABRIELLATENHAVE,PHD
BOARDOFDIRECTORS GerardL.Coté,PhD James J Cain Professor Director, Center for Remote Health Technologies and Systems Department of Biomedical Engineering BonnieJ.Dunbar,PhD TEES Eminent Professor Director, Institute for Engineering Education and Innovation Department of Aerospace Engineering JEFFREYLIEW,PHD Professor & Associate Dean for Research College of Education & Human Development Department of Educational Psychology Ex Officio Member 12 SusieRockway,PhD VP of Nutrition and Scientific Affairs The Bountiful Company (Nature's Bounty) Industry Advisor (Non Voting Member) RalfJäger,PhD Co Founder & Partner Increnovo LLC Industry Advisor (Non Voting Member) COSTASN.GEORGHIADES,PHD Delbert A Whitaker Professor and Senior Associate Vice President for Research Department of Electrical & Computer Engineering Ex Officio Member
TimothyElliott,PhD Distinguished Professor Executive Director Telehealth Counseling Clinic Department of Educational Psychology ShevonHarvey,PhD Associate Professor Director, Transdisciplinary Center for Health Equity Research Department of Health & Kinesiology * Moved to the University of Missouri in summer of 2021 13 KellyWilson,PhD Professor Division Chair Health Education Department of Health & Kinesiology
Major duties of the BOD include:
Membership Seats on the BOD are filled by appointment in consultation with the Deans of Colleges or Schools who have faculty interested in conducting independently funded, grant, and/or fee for service projects in the HCRF Colleges or Schools who have $100,000 in annual research expenditures and/or sponsored core services performed in the HCRF will receive 1 seat on the board, those who have $250,000 annually in research expenditures and/or sponsored core services performed in the HCRF will receive 2 seats on the board, and those who have $500,000 or more in annual research and/or sponsored core services performed in the HCRF will receive 3 seats on the board
The HCRF BOD will meet with the HCRF Directors semi annually to discuss progress and provide input about major initiativesThe meetings will be called and chaired by the ED with the CRD serving as Co Chair.The agenda will include discussion about management of the HCRF, fee for service activities provided since the last meeting, anticipated fee for service activities, budget overview, and related issuesThe BOD meetings will also be used to discuss future plans and initiatives including ways to encourage more TAMUS faculty to conduct research at the HCRF on a fee for services or grant basis
Reviewing and approving the annual fee for service rate study that is submitted for approval to the university.
The Board of Directors is comprised of a coalition of Colleges and Schools at Texas A&M University and external sponsors who have invested in providing annual support to conduct research in the HCRF This can be through providing mini-grants to their faculty for pilot studies, part of new faculty start-up packages, providing support for strategic research initiatives, and/or having interest in submitting grants or conducting research in the HCRF
The CEHD, as a major investor in the HCRF, will have in total 3 voting members, with at least one member from HLKN faculty (reflecting that department?s investments in the HCRF).The CEHD Associate Dean for Research and the VP for Research (or his/her representative) will serve as ex officio members Faculty from colleges and schools who are not currently conducting research in the HCRF may also be invited to serve on the Research or Education Committee and attend BOD meetings as non voting members to increase awareness and encourage engagement
Attending semi annual meetings with the HCRFExecutive Director and Director of Clinical Research - Establishing by-laws for HCRFgovernance to be agreed upon by a 2/3 majority vote
External sponsors from industry who commission a significant amount of FFS work in the HCRF may also be invited to attend BOD meetings as non voting industry advisors Board membership size will be determined annually based on changes in providing a commitment to funding and/or annual support of fee for service activities from collaborating colleges, schools, and/or external sponsors.Board members will be appointed by the Dean of participating College or School and/or external sponsors
Performing mid term and 5 year reviews of HCRFleadership
BOARDOFDIRECTORMEMBERSHIP
Reviewing and approving the annual HCRFoperating budget.
Providing input and feedback about facility and fee for service management issues
Vot ing Privileges
Identifying and providing input on major HCRFinitiatives
Dut ies
Each board member will receive one vote with the majority of votes carrying motions If a supporting college or school has more than one seat, the college or school can choose to have one board member cast more than one vote up to the number of seats they hold Board members can cast their votes by proxy if they are unable to attend the board meeting
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"Becomearesearchconsortiummemberbyinvestinginconducting clinicaltrialsattheHumanClinicalResearchFacility!" 15
In addition to PI?s housed in the HCRF conducting their independent research, the HCRF has been set up as a Human Clinical Core Service Center TAMUS Principal Investigators and external research sponsors can work with HCRF staff to collect data for them on a fee for service basis typically by ESNL staff Internal and external at cost rates have been approved by the university for each of the services and capabilities offered by the HCRFHCRFstaff will work with the PI?s to obtain IRB approval and collect data for them in the HCRF Once data are collected, the results are forwarded to the PI or external sponsor for their use Costs for services performed are invoiced monthly until the project is complete Faculty belonging to Colleges or Schools who are members of the HCRF Research Consortium receive discounts on FFS rates depending on their level of membership These colleges have designated some funding for their faculty to use for pilot and/or research projects PI?s interested in having the HCRF collect data on their IRB approved protocols should contact Dr Kreider to obtain an estimate of costs for doing their projects If there are other tests you are interested in having the HCRF perform that are not currently listed, contact Dr. Kreider to see if the HCRF has those capabilities and can obtain approval from the university for those services to be added to the list of services offered
COLLABORATION
SPACERENTAL
FEEFORSERVICE
SPACEALLOCATION
The HCRF was developed to be a resource for faculty at TAMU and the TAMHSC to conduct human clinical research trials.Faculty with funded research projects can request allocation of space and/or shared use of space within the HCRF to conduct their independent research If you would like to explore this option, contact Dr Jeff Liew, Associate Dean of Research in the College of Education and Human Development to discuss feasibility, shared costs, and approval Once approved, HCRF staff will then work with the PI?s to facilitate training of staff in using HCRFfacilities and reserving and/or allocating approved space.
CONDUCTINGRESEARCHINTHEHCRF
Outside CEHD and/or non resident PI?s at TAMU and the TAMUS can reserve use of 1 clinical study room, 1 exam room, or shared use of training facility in the HCRB for $25/hour (each charged separately as needed) to conduct their independent research studies through the iLab Human Clinical Core website. The outside CEHD and/or non resident PI is responsible to cover HCRFpersonnel costs for any necessary training to use the HCRF and all HCRF related supplies needed to do their independent work Those wishing to reserve use of space in the HCRFB should first discuss the project with Dr. Kreider to determine feasibility.All projects must be approved by the IRB and the HCRFresearch coordination committee 16
The HCRF currently houses seven Principal Investigators who have significant clinical research experience assessing the role of exercise and nutrition on health, performance, rehabilitation, and/or disease risk/management in healthy and medically-controlled clinical populationsThey conduct independently managed research in the HCRF via the center and labs housed in the HCRF.As shown in the list of funded clinical trials, they collaborate with other PI?s as Co PI?s or COI?s on grant proposals of mutual interest with researchers at TAMUSFor more information, contact HCRF Resident PI?s directly to discuss potential collaborations
INITIATINGPROJECTS
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The HCRFDirector will discuss the various options on how to conduct research in the HCRFand refer the faculty or external sponsor to the appropriate HCRFcenter/lab director to discuss collaboration and/or fee for service (FFS) testing options
Data collected by the HCRFfor FFSactivities will be managed and stored at the HCRFas per approved IRB under the supervision of the service conducting HCRFPI
Potential fee for service projects will be directed to Dr. Kreider. If the HCRFExecutive Director feels the project can be done in the HCRFon a FFSbasis, he will work with faculty or external sponsor to develop a budget proposal. Once the scope of work and budget estimate are finalized, the anticipated budget and payment terms will be forwarded to the sponsor to obtain a commitment to fund the project HCRFstaff will not begin working on the project until the agreement to fund the project is executed
The faculty and/or sponsor will be billed monthly for testing services performed, non budgeted supplies, and participant stipends
Faculty members and external sponsors can follow the process below to initiate collaborative research with resident PI?s and/or fee for service (FFS) projects in the HCRF. Fee for service projects are independent from resident PI?s research efforts.
Once approved, a copy of the signed IRB will be forwarded to the HCRFResearch Review Committee for review and approval. HCRFstaff will explain the procedures related to any testing to be conducted in the HCRFprior initiation of any test.
- Faculty and/or sponsors who requested the FFSactivity will have access to non-personally identifiable data for independent analysis and publication.
If the faculty member and/or their students want to assist in data collection, they must complete all necessary university, HCRF, and related lab/center training and compliance requirements and be listed on the IRB as study personnel
The HCRFwill be acknowledged in all publications resulting from FFSactivities as the site of data collection.
Faculty and/or potential grant sponsors interested in collaborating with resident PI?s should contact them directly Potential collaborations involving CTRAL should contact Dr Deutz Potential grant collaborations involving the ESNL should contact Dr Kreider Research involving use of the Human Centrifuge should contact Dr Diaz Artiles If potential collaboration involves more than one lab/center, each director will be involved in discussions Since the center and labs housed in the HCRF operate independently, they will work directly with faculty on developing proposals of mutual interest.
If a faculty member or external sponsor wants to conduct research in the HCRF, they should contact the HCRFExecutive Director (Dr. Richard Kreider) to discuss the project.
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If a faculty member or sponsor wants the HCRFto perform a service not currently on the approved list of services, HCRFstaff will submit a request to add the service to the Department of Accounting Services in the Division of Finance & Operations for approval - For FFStesting performed for non-resident PI?s, HCRFstaff will work with the PI to make sure they have necessary information to describe HCRFtesting, facilities, and oversight for their IRB application.
COLLABORATINGFACULTY AgricultureandLifeSciences Adelaman, Zach * Allred, Clinton ? Athrey, Giri Awika, Joseph ? Bazer, Fuller ? Botezatu, Andreea Chapkin, Robert ? Chew, Boon ? Dangott, Lawrence Eastes, David Faries, Mark *?? Ford, James Giles, Erin Guo, Shaodong Jayaprakasha, G K * Jayaraman, Arul ? Kubena, Karen Liska, DeAnn Miller, Rhonda ? Murano, Peter ?? Outley, Corliss Palma, Marco ? Patil, Bhimu *? Smith, Stelbe Smith, Steven ? Sun, Yuxiang Talcott, Steve ? Talcott, Susanne *?? Tedeschi, Luis Threadgill, David Walzem, Rosemary ? Welsh, Thomas White, Sarah Wu, Chaodong ? Wu, Guoyao ? Xie, Linglin Architecture Ahn, Ryan Brown, Robert ? Lee, Chanam ? Li, Dongyin Pentegrass, Ray ? Li, Wei ? Thomas, Andre Xu, Minjie Zhipeng Lu ? Zhu, Xuemei ? Athletics Bramhall,, JP *?? Gray, Howard Education&Human Development Apostolopoulos, Yiorgos ? Buchanan, John ?? Crouse, Stephen ?? Deutz, Nicolaas *?? Engelen, Marielle *?? Fluckey, Jim ?? Gagne, Jeffrey * Greenwood, Lori ? Greenwood, Mike *?? Harvey, Idethia S* Kennedy, Deanna ? Kreider, Richard *?? Lawler, John Lei, Yuming * Lightfoot, John Martin, Steven ?? Moore, Melinda ? Riccio, Cynthia Riechman, Steven ?? ten Have, Gabrie * Thompson, Julie Woltering, Steven * Woodman, Christopher Wright, David Yentes, Jenna * 18 Engineering Artiles, Ana Diaz *? Birgisson, Bjorn Biswas, Saurahb ? Braga Neto, Ulisses M Bukkapatnam, Satish * Chamitoff, Gregory * Chaspari, Theodora ? Conroy, Bryan Cote, Gerard * Currie Gregg, Nancy Dunbar, Bonnie ? Guiseppi Ele, Anthony * Fields, Sherilyn Fink, Rainer * Gutierrez Osuna, Ricardo ? Hammond, Tracy ? Haridas, Balakrishna Hogan, Harry ? Hsieh, Sheng Jen "Tony" Hur, Pilwon *? Jafari, Roozbeh ?? Jayaraman, Arul Kent, TA ? Kim, Jeonghee *? Langari, Gholamreza ? Lawley, Mark Lee, Kiju *? Mariani, Sara Mcdougall, Mary McShane, Mike * Metha, Ranjana *? Moreno, Michael Mortazavi, Bobak ? Noren, David Pagilla, Prabhakar ? Park, Hangue *? Sasangohar, Farzan Song, Dezhen Staack, David * Thomasson, Alex ?? Wang, C?
Zeng, O"Neill ? Zhang, Xudong ? Zoghi, Behbood ? Geosciences Dimarco, Steve ? Knap, Anthony ? Worthy, Darrell ? HealthScienceCenter Hook, Magnus Gomez, Jorge ? Green, Sheila ? Mogford, Jon Sohrabji, Farida ? Wang, Fen Young, Keith Pharmacy Choudhury, Mahua ? Han, Guichun Kahn, Mansoor ? Reddy, Indra ? LiberalArts Alexander, Gerianne ? Bernard, Jessica *?? Fields, Sherecce ?? Howard, Daniel Lee, Kiju * MacNamara, Annmarie ? McLaughlin, Tim Meaghar, Mary * Worthy, Darrell Medicine Alpini, Gianfranco Bagher, Pooneh ? Carpenter, Robert ? Chen, Chieh ? Dashwood, Rod Earnest, David Fuchs-Young, Robin Gashev, Anatoliy Glaser, Shannon Griffith, William Han, Gang Hartman, Greg Huston, David P. Ji, Jun yuan Kent, Thomas ? McKeehan, Wallace Meininger, Cynthia ?? Muthuchamy, Mariappan Reddy, Samba ? Rice Ficht, Allison C Rutkowski, Joseph Scholtz, J Martin Selvamani, Amutha ? Sohrabji, Farida Srinivasan, Rahul ? Walker, Cheryl ? Wilson, Van ? Young, Keith Zaweija, David ?? Nursing Dormier, Sharon ? Downing, Nancy *? Neal, , Colleen * Page, Robin * Taylor, Brandie * PublicHealth Benden, Mark ? Clarke, Heather ? Han, Gang ? Ma, Ping ? McKyer, Lisako ? Ory, Marcia *? Payne, Stephanie ? Sharkey, Joe 19 Smith, Matthew ? Town, Samual Yoshkawa, Aya Zhao, Hongwei ? Science Blackmon, Heath ? Bluemel, Janet Gomer, Richard ? Johnson, Valen ? Jung, Junehyuk McKnight, Thomas Sang, Huiyan ? Schuessler, Hans Scott, Timothy VeterinaryMedicine Burghardt, Robert C Ivanov, Ivan Ko, Gladys Newell Fugate, Annie ? Shridhar, Vidya Welsh, Jane ? Weston, Porter ? Other Abbasi, Qammer Akinyi Joseph, Grace Blaze, Kelly Davies, Ronald Hellman Jason Kesterke, Matthew ? Rosa, Robert Schwager, Emma Sherriff, Lt Comm Li,Yi List of faculty who have toured, requested information, and/or collaborated with HCRF resident-PI's Total faculty engagement (213) * PI/CoPI on FFS project (32) ? PI/ CoPI on funded grant s (31) ? PI/ CoPI on subm it t ed grant (77)
20 GeneralServices IRB Application Assistance - Data & Safety Monitoring - Scheduling Data Entry / Analysis Study Management - Nursing Consultation - Off-Site Participant Monitoring Consulting - Study Exam Room Rental for Independent data collection - Training/Rehabilitation Access for Independent Research HealthPopulationServices Recruitment (Apparently Healthy) Entrance Criteria (Apparently Healthy) - Phlebotomy - Phlebotomy (Finger Stick) Muscle Biopsy Fat Biopsy - Urine Collection Saliva Collection Height / Weight / BMI - Bioelectrical Impedance (BIA) - Skinfold Body Composition Body Composition/Density (DEXA) - Resting Energy Expenditure - Submaximal Exercise Test Flexibility Test ECG Stress Tests - Cardiopulmonary Stress Test - Endurance Capacity Test Anaerobic Capacity Test - Isotonic Strength Assessment - Isokinetic Strength Testing (KinCom) HUMANCLINICALCORESERVICES
21 - Algometer Pain Assessment - Dietary Record (4-d) Cognitive Function / Psychological Assessment Exercise Training (group training) - Sample Storage Record Storage ClinicalPopulationServices - Recruitment for Clinical Study (Chronic Diseases) Recruitment for Clinical Study (Healthy) Screening for Clinical Study - Finger Stick (Glucose & Lactate) Phlebotomy Placement of Indwelling Catheter - Hourly IV Blood Collection - Continuous Glucose Monitoring IV solution infusions (not including tracers and pharmacy) - Nursing Supervision - Height / Weight/ BMI Resting Cardiovascular Hemodynamics and Respiration Bioelectrical Impedance (BIA) - Body Composition/Bone Density (DEXA) - Lung function Handgrip - Resting Energy Expenditure - Isokinetic Strength Testing (KinCom) Gait Analysis Dietary recall (24h) - Neuropsychological Testing/Analysis Clinical Dietary Recall (3 d) 6 Minute Walk Test - Balance Assessment - Exercise Rehabilitation (Group Sessions) Sample Storage Record Storage
22 ANALYTICALSERVICES - CBCw/Differential Panel Comprehensive Serum Panel (Enzyme Panel) - Comprehensive Serum Panel (Full Comprehensive) Comprehensive Serum Panel (Glucose & Lipid Panel) - Amino Acid Concentration Profile in Plasma/Blood - Hormone Analysis (e.g., ELISA or EIA) ? Average Kit Cost Hormone Analysis (e.g., ELISA or EIA) ? High Cost Kit - Hormone Analysis (e.g., ELISA or EIA) ? Low Cost Kit Saliva Analysis - Sample Handling & Preparation (Healthy) - Sample Prep/Handling (Clinical) - Sample Storage (Healthy) - Sample Storage (Clinical) Urine Analysis
23
FEEFORSERVICERATES 24 ClinicalPopulationRecruitment Recruitment for Clinical Study Chronic Diseases $635.46 Recruitment for Clinical Study Healthy $408 24 Screening for Clinical Study $238 28 ClinicalPopulationServices Finger Stick (Glucose) $37 33 Finger Stick (Lactate) $28.43 Phlebotomy Venipuncture $80.34 Placement of Indwelling Catheter $139 07 Hourly IV Blood Collection $406 57 Continuous Glucose Monitoring $246 27 Muscle Biopsy $202 84 Fat Biopsy $202.84 IV Solution Infusions (not including the cost for tracers and pharmacy) $99.94 24 hour Nursing Supervision $1,589 60 Height / Weight/ BMI $35 52 Bioelectrical Impedance (BIA) $64 02 Body Composition/Bone Density (DEXA) $117.54 Lung function $61.91 Handgrip $51.26 Resting Energy Expenditure $103 86 MIP MEP $66 99 Isokinetic Strength Testing (KinCom) $136 80 Gait Analysis $121.20 Dietary recall (24h) $126.82 Neuropsychological Testing/Analysis $148.84 Clinical Dietary Recall (3 d) $180.41 6 Minute Walk Test $65 43 Balance Assessment $88 28 Urine Collection $40 66 Study Meal or Supplement Administration $104.49 Exercise Rehabilitation (Group Sessions) $94.62 Data Entry / Analysis (Clinical) $90 77 Off site Participant Monitoring $63 04 Study Management (Clinical) $81 30
25 Nap Study $549.54 Overnight Sleep Study $1,020 94 Record Storage $43 84 HealthyPopulationRecruitment Recruitment Apparently Healthy $164 96 Entrance Criteria Apparently Healthy $46 84 HealthyPopulationServices Phlebotomy Venipuncture $33 63 Phlebotomy (Finger Stick) $25 22 Muscle Biopsy $73 90 Fat Biopsy $73.90 Urine Collection $34.61 Saliva Collection $31.83 Height / Weight / BMI $23 97 Bioelectrical Impedance (BIA) $28 34 Skinfold Body Composition $25 22 Body Composition and Bone Density Assessment (DEXA) $39.05 Resting Energy Expenditure $68.78 Submaximal Exercise Test $53 31 Flexibility Test $23 34 ECG Stress Tests $57 68 Cardiopulmonary Stress Test $187 55 Endurance Capacity Test $187 55 Anaerobic Capacity Test $49.54 Isotonic Strength Assessment $35.62 Isokinetic Strength Testing (KinCom) $74 28 Algometer Pain Assessment $27 18 Dietary Record (4 d) $38 12 Cognitive Function / Psychological Inventory Assessment $33.59 Exercise Training (3 sessions per month/group training sessions/hours) $124.69 Schedule / Phone Screen $8.53 Study Management (Healthy) $59 21 Ratesapprovedby theDepartment of AccountingServicesin theDivisionof Finance&Operationsandare effectiveuntil August 31, 2023. External sponsorsarecharged10%aboveinternal rates.
26 FEEFORSERVICERATES AnalyticalServices CBC w/Differential Panel $28.43 Comprehensive Serum Panel (Full Comprehensive) $51.60 Comprehensive Serum Panel (Glucose & Lipid Panel) $40 10 Amino Acid Concentration Profile in Plasma/Blood $240.14 Hormone Analysis (e g , ELISA or EIA) Low Cost Kit $55 31 Hormone Analysis (e g , ELISA or EIA) Average Kit Cost $61 56 Hormone Analysis (e.g., ELISA or EIA) - High Cost Kit $67.81 Immulite Analysis Low Cost Assay $52 39 Sample Handling & Preparation (Healthy) $57 20 Sample Handling & Preparation (Clinical) $67.10 Sample Storage (Healthy) $35 01 Sample Storage (Clinical) $108.14 GeneralServices IRB Preparation (Clinical Population Study) $3,124.87 IRB Preparation (Apparently Healthy Study Population) $2,610.67 Record Storage (Healthy) $19 40 Record Storage (Clinical) $47.37 Scheduling $6 90 Data Entry / Analysis (Clinical) $105 17 Data Entry / Analysis (Healthy) $70.69 Study Management (Clinical) $81 30 Study Management (Healthy) $59 21 Nursing Consultation $75.74 Off site Participant Monitoring $63 04 Data & Safety Monitoring (per hour) $77 55 Consulting (per hour) Kreider $190.87 Consulting (per hour) Deutz $216 25 Parking $5.00 PPE $12.50
27 SpaceRental* Study / Exam Rooms (per hour, ea.) $25.00 Rehab/Training Facilities (per hour for shared access) $25.00 Ratesapprovedby theDepartment of AccountingServicesintheDivisionof Finance&Operationsandareeffectiveuntil August 31, 2023. External sponsorsarecharged 10%aboveinternal rates. * Hourlycharge for non-CEHD PI'sto reserveuse of 1 clinical studyroom, 1 exam room, or shared useof thetraining/rehabilitation facilityin theHCRF(each charged separatelyas needed). Thisfeeisjust for accessand useof thesefacilitiesfor independent research usingtheir staff to collect data. The non-resident/non-CEHD PI isresponsibleto cover HCRFpersonnel costs for anynecessarytrainingto usetheHCRFand all suppliesneeded to do their independent work. Thosewishingto reserveuse of spacein theHCRFshould first discusstheproject with the HCRFdirectors. All projectsmust be approved bytheIRBand the HCRFresearch coordination committee. The CEHD hassubsidized useof HCRFfacilitiesfor non resident CEHD PI's. Therefore, thischargeisonlyfor non CEHD PI's.
BUDGET&RESOURCES 28 * As of 7/31/22
29 * Private and federal IDCestimate represents cumulative IDC's generated from HCRFPI contribution to total awards ** FFSadministrative fee generation based on annual invoices * As of 3/31/22 ** Private and federal external funding generated from HCRFPI contribution to total awards for work done in the HCRF * As of *7/31/22 As of 3/31/22
BYTHENUMBERS 213 fACULTY engagement (14Col l eges) 31 submit t ed gr ant s ($21.7M) 84 pr oject Pr ot ocol s 30 29 tamu PI ffs pr oject s (32facult y/ 7Col l eges) 20 ext er nal ly SPONSOREDFfs pr oject s 51 2021 publ icat ions (r esident pi's only) 73 pi's/ CoPi'son pr oposal s (10Col l eges) 31 pi's/ CoPi'son fundedgr ant s (9 Col l eges) 56 per cent incr easein ffs r evenue
41 Feefor service pr oject s $3.1M $14.5M FUNDINGt odor esear chinHCRF $32.0M TOTALAWARDAMOUNT 31 43 gr ant s &cont r act s $11.4M
Dr Ana Diaz Artiles
NEWSANDINITIATIVES
After over three years of planning and construction, the Aerospace Engineering Human Centrifuge Annex is about to be completed The Annex will house the only short radius human centrifuge in the United States The Human Centrifuge was previously housed at the University of Texas Medical Branch (UTMB) in Galveston, TX Former astronaut and Professor of Aerospace Engineering, Dr. Bonnie Dunbar, obtained approval from NASA to relocate the centrifuge to TAMU. After considering various location options, it was decided that the HCRF would be an ideal location. Efforts then began to obtain approval from the CEHD and University to build the annex Costs are being covered by Dr Dunbar's start up funds (about $1 2 million) as well as a $657,853 TAMU Research Development Fund grant that was awarded in the spring of 2020 The human centrifuge facility will be directed by Dr Ana Diaz Artiles who did research using a similar facility when she was at Massachusetts Institute of Technology. Additional faculty are being recruited who will contribute to this area. The Human Centrifuge is currently undergoing operational and safety checks in collaboration NASA collaborators with several related fee for service and/or grant related projects underway and/or in the planning phases
AerospaceEngineeringHumanCentrifugeAbouttoLaunch!
"Exposuretowe
ightlessnessresultsintheremovalofhydrostatic pressuregradientsandapermanentheadwardfluidshift,causinga redistributionofblood.Thishascurrentlyunknownconsequences, butitmightberelatedtoaseriesofneuro-ocularandfunctiona l changesdevelopedinsomeastronautsduringbothshortand long-durationspaceflight,knownasSpaceflightAssociated Neuro-OcularSyndrome(SANS).Inthisscenario,countermeasures focusedonproducinghydrostaticgradientsorreducingthe microgravity-inducedfluidshift,suchascentrifugation,become particularlyinteresting.WiththenewTAMUcentrifugewewillbe abletoinvestigatetheoverallphysiologicalresponseofaparticular "dose"ofalteredgravity,thuscontributingtothedevelopmentof newcountermeasureandastronauthealth" Dr.AnaDiaz-Artiles
32
Dr Bonnie Dunbar
33
34 NEWSANDINITIATIVES
Priority is given to funded research studies of resident PI's followed by non resident PI's
NewOptionsforNon-ResidentPI"satTAMUtoUsetheHCRFApproved
IDevelopmentProgramLaunched
Non-ResidentP
One of the challenges of conducting human clinical trial research at Texas A&M is that although there is interest, many faculty do not have experience conducting human research. In an effort for faculty to help develop these skills, the CEHD launched a new Catapult: Human Clinical Research Fellowship Grant that provides $8,000 for faculty who have not done research in the HCRF to obtain training needed to conduct research, prepare a grant, and submit a proposal for research that will be conducted in the HCRF Once completed, the Fellow will become a non Resident PI who can conduct their research in the HCRF just like resident PI's For more information, see information on the College of Education Research Development website or contact Dr Kreider 2021RateStudyCompleted Every two years, the University asks that we evaluate our services and rates We are required to determine the actual costs of conducting the services including indirect and administrative costs, costs for personnel time to conduct the testing, supplies, and equipment Additionally, we must justify our rates in relation to fair market value. The most recent rate study was approved January 15, 2022 and is effective until August 31, 2023. Current approved rates can be found on pages 24 28 of this report.
Faculty have always been encouraged to use the HCRF to conduct their human clinical research trials In fact, the HCRF is has been home to over 80 IRB approved clinical trials that include over 20 independent research studies that HCRF staff are collecting data for independent PI's on a fee for service (FFS) bases, about 29 projects led by resident PI's in collaboration with a number of faculty across campus, and 20 FFS studies that external sponsors have commissioned researchers in the HCRF to conduct. However, over the last several years there has been interest from independent PI's across campus to be able to reserve space in the HCRF so they can conduct IRB and HCRF approved protocols where they provide their own staff and supplies to collect data. As a result, we obtained approval from the university to allow non resident PI's to reserve study rooms, exam rooms, and/or shared access to training/rehab facilities at a nominal hourly fee through the Human Clinical Core service center iLab portal Faculty interested in this option should contact Dr Kreider to discuss the feasibility of conducting the study in the HCRF If appropriate, HCRF staff will provide the necessary information for the PI to obtain IRB approval to list the HCRF as a site for data collection Once the IRB is approved, the faculty member will submit their IRB to the HCRF research coordination committee (RCC) for approval and planning that is chaired by Dr. Mick Deutz. HCRF staff will also work with the PI to make sure all of their staff has the necessary training to collect data in the HCRF Once completed, the PI will work with Darlene Whyte to schedule needed space Space is only allocated after the IRB is approved by the RCC and all staff complete necessary training
HCRFResident-PI'sandFeeForServiceProgramSettingRecords!
As part of the university's academic and administrative realignment, the university has decided to administratively house the HCRF under the Texas A&M Health Science Center effective September 1, 2022. While it is unclear how this may affect management of the HCRF and/or our Human Clinical Core service program, there will undoubtedly be changes on the horizon We believe we have made great strides in serving university faculty wanting assistance in conducting human clinical research over the years as engagement and productivity measures clearly show We look forward to working with the TAMHSC in supporting human clinical research at TAMU 35
In the 2019 annual report, it was noted that we made significant progress obtaining grants and increasing FFS revenue generation Until COVID hit, we were on pace for another record setting year Below is an overview of some of the records achieved last year Despite the 3 5 month suspension of human participant research at TAMU in 2019, I'm pleased to report we still broke records once again! In 2021, the number of FFS projects for TAMU faculty (+45%) and external sponsors (+18%) increased resulting in a +33% increase in FFS revenue generation. Improvements were also seen in the number of collaborating faculty (+23%), number of fee for service projects launched (+32%), and number of active protocols (+40%). There was also a 65% increase in active grants, a 26% increase in active grant funding, a 13% increase in total external funding engagement by resident PI's, an 82% increase in the number of grants submitted, and a 44% increase in the amount of submitted grant proposals Resident PI's also published a record 51 articles in 2021 (+42%) We would like to thank all of the dedicated researchers, staff, and students who helped the HCRF thrive despite navigating through the challenge of COVID 19 HCRFTRANSFERTOHEALTHSCIENCECENTER
CONSORTIUM MEMBERS INDUSTRY ADVISORS INTERNAL SPONSORS RESEARCHSPONSORS 36
FEDERAL SPONSORS PRIVATE SPONSORS 37
Funds Status: IRB Approved, Finalizing Device Development Propriocept ive Augm ent at ion using Proxim it y Feedback via Transcut aneous Elect rical St im ulat ion for Rehabilit at ion of Elbow Joint Movem ent aft er Propriocept ive Loss PI: Park, H (Electrical and Computer Engineering) Amount of Funding: $30,000 Source of Funding: College of Engineering Consortium Funds Status: IRB Approved and in Planning Phase Enhancing Therapeut ic Device Adherence of Children w it h ADHD: An Efficacy Trial PI: Guiseppi Elle (Biomedical Engineering) Amount of Funding: $17,102 Source of Funding: College of Engineering Consortium Funds Status: IRB approved / PI moved Effect s of Mosquit o Bit es on Skin React ion and Perceived It chiness PI:Adelman (AGLS) Amount of Funding: $5,300 Source of Funding: Department of Entomology Data collection by ESNL staff Status: IRB Approved Decided Not to Conduct Due to COVID Delays 38
ion
Status: Device
PI: Hur
edical Inst rum ent
Source
Lim b Trem
PI:
FUNDEDSERVICEPROJECTS SERVICEPROJECTSCONDUCTEDFORTAMUFACULTY
and Industrial Distribution)
ent
Source
Longit udinal
Amount of Funding: $37,177 of Funding: College of Engineering Consortium
Amount of Funding: $29,312 of Funding: College of Engineering Consortium Funds Data Collection Progress Biom at Developm Grant (Engineering Technology and Technology
The HCRFoffers
in
a fee for service option for faculty at TAMU and external sponsors to commission projects where staff in the HCRF(primarily the ESNL) collect data for them on their independent projectsThe following provides a list of projects conducted for TAMU faculty Note, CTRAL is no longer contributing to the fee for service program so they can focus on conducting grant related research DataCollectedbyESNL Augm ent ing Exercise Prot ocols w it h Int eract ive Virt ual Realit y Environm ent s PI: Diaz Artiles (Aerospace Engineering); CoPI's: Chamitoff (Aerospace Engineering), Moore (HLKN)
Source
SpO2
Industrial Distribution); CoPI: Fink (Engineering
Status:
Amount of Funding: $22,500 of Funding: College of Engineering Consortium Funds in Development Upper or Wrist Device Kim (Engineering Technology and Industrial Distribution)
Measurem ent and Act ivit y Recognit ion for People w it h Arm Dom inant Trem or via a
Biom arkers of St ress and Pain Follow ing Sexual Assault :A Feasibilit y Pilot St udy PI:Downing (Nursing); CoPI; Meagher (Nursing) Amount of Funding: $37,242 (Two studies) Source of Funding: College of Nursing Status: Recruitment and Sample Collection in Progress Long Term Genet ic Sam ple St orage PI:Gagne (EPSY) Amount of Funding: $4,191 Source of Funding: Department of Educational Psychology Faculty Start Up Funds Status: Samples Stored Prot ect ive Fact ors Against St ress and Pret erm Birt h in Pregnant African Am ericans PI:Page (Nursing); CoPi's: Neal (Nursing), Taylor (Nursing) Amount of Funding: $10,021 Source of Funding: College of Nursing Status: Recruitment and Sample Collection in Progress St ress, Cognit ive Im pairm ent , and Self Managem ent Behaviors Am ong Rural Minorit ies Diagnosed w it h Type 2 Diabet es PI: Harvey; CoPI: Bernard Amount of Funding: $14,469 Sponsor: 2020 CEHD Catapult Seed Grant Status: IRB Approved Delayed due to COVID PI moved Effect s of t he GoLo Weight Loss Program on Body Com posit ion PI: Talcott (AGLS) Amount of Funding: $2,352 Sponsor: GoLo, Inc Status: Completed COVID19 Breat h Analyzer Validat ion St udy PI: Staack (CoE/Meng) Amount of Funding: ($50,000) Sponsor: Meng as part of NFSgrant Status: In progress e Cube Gam ing St udy PI: Lee (CoE/Eng Tech Ind Dist) Amount of Funding: $7,500 Sponsor: Psychology Status: Completed 39
FUNDEDSERVICEPROJECTS DataCollectedbyCTRAL (Focusing on Grants Only Now) Dayt im e Sleep in Subject s w it h Mild Cognit ive Im pairm ent (MCI) PI: Bukkapatnum (Industrial and Systems Engineering); CoPI: Woltering (EPSY) Amount of Funding: $43,892 Source of Funding: College of Engineering Consortium Funds Status: Completed The Relat ion bet w een t he Meal Macronut rient Dist ribut ion and Plasm a Met abolit es t o Model t he Com posit ion of Meals of Pat ient s w it h Type 2 Diabet es and Cardiovascular Disease PI: Cote?(Biomedical Engineering) Amount of Funding: $100,01 Source of Funding: College of Engineering Consortium Funds Status: Completed Isoleucine Int ake and Int erm ediary Met abolism in Type 2 Diabet es PI: Park (Electrical and Computer Engineering) Amount of Funding: $50,211 Source of Funding: College of Engineering Consortium Funds Status: Data Collection Completed Skelet al Muscle Response t o Leg Exercise in Subject s w it h and w it hout COPD PI: Wright (Electrical and Computer Engineering) Amount of Funding: $42,401 Source of Funding: College of Engineering Consortium Funds Status: Data Collection Completed Neural Cont rol of Mot or Funct ion w it h Obesit y PI: Mehta (Industrial & Systems Engineering) Amount of Funding: $55,000 Source of Funding: College of Engineering Consortium Funds Status: In Progress Wearable Syst em s for Accurat e Nut rit ional Monit oring PI: McShane (Biomedical Engineering) Amount of Funding: $82,000 Source of Funding: College of Engineering Consortium Funds Status: Data Collection in Progress Insight in t he Com plex Met abolic Dist urbances Underlying Sepsis and t he Response t o Target ed Nut rit ional Modulat ion PI: ten Have (HLKN) Amount of Funding: $12,500 of $30,000 total award Sponsor: CEHD Catapult Seed Grant (Internal) Status: Data Collection Completed PrOt eiN DigEst ibilit y and Recovery in Pat ient s Undergoing Aut ologous St em Cell Transplant PI: Deutz (HLKN) Amount of Funding: $2,979 Sponsor: Ponder Endowment (Internal) Status: Data Collection Completed 40
PI: Kreider (HLKN) on behalf of Russ Anderson Amount of funding: $151,167 Sponsor: Anderson Advanced Ingredients / Shoreline Fruit Status: Collection in Progress
Sponsor: Natreon Let to multi year grant project in progress
PI: Kreider (HLKN) on behalf of Dr. Susie Rockway (Nature?s Bounty) Amount of funding: $662,800
SERVICEPROJECTSCONDUCTEDFOREXTERNALSPONSORS
DataCollectedbyESNL Nat reon Research & Developm ent Program Planning Grant PI: Kreider (HLKN) Amount of funding: $7,879 planning grant
Effect s of Paraxant hine Supplem ent at ion w it h and w it hout Caffeine on Execut ive Funct ion and Perform ance TAMU PI: Kreider (HLKN) on behalf of Dr Martin Purpura & Dr Ralph Jäger (Increnovo) and Dr Shawn Wells (WGI)
A Cross Over Com parat or St udy Bet w een Est er C® and Ascorbic Acid Evaluat ing Acut e Pharm acokinet ics in Adult Wom en and Men
Sponsor: The Nature?s Bounty Co. Status: Data Analysis in Progress
TAMU PI: Kreider (HLKN) on behalf of Dr Martin Purpura & Dr Ralph Jäger (Increnovo) and Dr Shawn Wells (WGI) Amount of funding: $103,616 Sponsor: Increnovo / WGI
TAMU PI: Kreider (HLKN) on behalf of Dr. Martin Purpura & Dr. Ralph Jäger (Increnovo)
Effect s of Varying Doses of Paraxant hine Supplem ent at ion on Execut ive Funct ion
Amount of funding: $49,061 Sponsor: Increnovo / Specnova Status: Data Analysis in Progress
Effect s of nooLVL? Ingest ion on Cognit ive Funct ion in Gam ers
41
Status: Data Collection Completed
TAMU PI: Kreider (HLKN) on behalf of CRO Jim Komorowski and Sara Perez Ojalvo Amount of funding: $152,167 Sponsor: Nutrition 21 Status: Data Collection and Analysis Completed. Effect s of Tart Cherry Ingest ion on Food Induced Serum Uric Acid Elevat ion
Effect s of Ashw agandha and Paraxant hine Ingest ion on Execut ive Funct ion
Amount of funding: $96,643 Sponsor: Increnovo / WGI Status: Data Analysis in Progress.
FUNDEDSERVICECONTRACTS Efficacy of a Microalgae Ext ract PhaeoSOL on Opt im izing t he Benefit s of Overw eight and Moderat ely Obese Wom en Part icipat ing in an Exercise and Weight Managem ent Program PI: Kreider (HLKN) on behalf of Dr Martin Pupura and Dr Ralf Jäger (Increnovo) and Ilya Zhivkovich (MicroPhyt) Services Invoiced to Date: $201,607 Sponsor: MicroPhyt (France) Status: Data collection in progress Efficacy of a Microalgae Ext ract PhaeoSOL com bined w it h Guarana on Cognit ive Funct ion and Gam ing Perform ance of Video Gam ers PI: Kreider (HLKN) on behalf of Ilya Zhivkovich (MicroPhyt) Services Invoiced to Date: $154,068 Sponsor: MicroPhyt (France) Status: Data collection in progress Efficacy of Energy Drinks Cont aining Paraxant hine on Execut ive Funct ion PI: Kreider (HLKN) on behalf of Dr Martin Pupura and Dr Ralf Jäger (Increnovo) Amount of funding: $237,450 Sponsor: Increnovo Status: Proposal Approved and ending Effect s of Varying doses of Ashw agandha Supplem ent at ion on Execut ive Funct ion TAMU PI: Kreider (HLKN) on behalf of Dr Martin Purpura & Dr Ralph Jäger (Increnovo) Amount of Funding $53,045 Sponsor: Increnovo / WGI Status:IRB approved Pending Effect s of Alpha Glyceryl Phosphoryl Choline (A GPC) Ingest ion on Cognit ive Funct ion in Gam ers PI: Kreider (HLKN) Amount of Funding:: $42,756 Sponsor: ChemiNutra Status: On hold due to COVID A Random ised, Double blind, Placebo Cont rolled, Parallel St udy of t he Effect of BrainPhyt on Cognit ive Funct ion in Healt hy Older Individuals HCRFPI: Kreider (HLKN) on behalf of Ilya Zhivkovich (MicroPhyt) Amount of Funding: $3,156 as FFS, $184,194 as grant Sponsor: MicroPhyt (France) Status: Recruiting Participants Pharm acokinet ic Analysis of Nut rient Absorpt ion from a Novel Liposom al Mult ivit am in / Mineral Form ulat ion HCRFPI: Kreider (HLKN) on behalf of Max Willis (Nutraceutical Corp) Amount of Funding: $3,156 as FFS, $134,079 as grant Sponsor: Nutraceutical Corp Status: Data Analysis Secure Reposit ory for Academ ic Research St udy HCRFPI: Kreider (HLKN), PI?s: Brackett (CoE/TEES) and Adkins (Identify3D) Amount of Funding: $6,816 Sponsor: Subcontract from Identify3D on DARPA funded project (Federal) 42
The HCRFprovides a resource for resident and non resident PI?s to conduct human clinical research at Texas A&M in College Station as well as for external sponsors to fund fee for service projects and/or grants and contractsThis has resulted in numerous collaborations across campus, proposal submissions, and funded grants and contractsThe following provides a list of federal, private and internally funded grants to support research conducted in the HCRF and/or in collaboration with PI?s across campusThis list is divided into federal, private, and internal grants awarded to PI?s from Aerospace Engineering, CTRAL, the ESNL, the HCRF, and HLKN
DataCollectedbyCTRAL Am ino Acid Analysis
Funding Source:National Aeronautics and Space Administration (NASA) through TEES Conducted with assistance by staff in the ESNL
TAMU PI: Detuz (HLKN) on behalf of Dr Mette Berger (CHUV) Services Invoiced: $89,170 Sponsor: Lausanne University Hospital, Switzerland Status: Completed Cit rulline Analysis
HCRFPI: Deutz (HLKN) on behalf of Allerton (PBRC) Services Invoiced: $8,478 Sponsor: Pennington Biomedical Research Center (PBRC), LSU (Private)
Status: Completed EXTERNALLYFUNDEDGRANTSANDCONTRACTS
PI: Diaz Artiles Amount of Funding: $150,000
Predict
CTRAL Engineering Research Cent er for Precise Advanced Technologies and Healt h Syst em s for Underserved Populat ions (PATHS UP) Co PI: Deutz (HLKN), Cote?(Biomedical Engineering) Amount of Funding: $618,000 of $12,268,000 Funding Source: National Science Foundation (Federal) 43
AerospaceEngineering ing Acut e Cardiovascular and Ocular Changes Due t o Changes in t he Gravit at ional Vect or and Effect s of Count erm easures
FEDERALGRANTS
GRANTS&CONTRACTS
PI?s: Prof Ana Diaz Artiles, Dunbar (Aerospace Eng), Deanna Kennedy (HLKN)
Amount of Funding: $430,000 Sponsor: National Aeronautics and Space Administration (NASA) (Federal)
Effect s of Alt ered Gravit y on Percept ion and Bi m anual Coordinat ion: Im pact s on Funct ional Perform ance
A Longit udinal Invest igat ion of t he Cerebellum in Adult hood: Anat om ical and Net w ork Changes, Mot or Funct ion, and Cognit ion
Sponsor: National Institutes of Health (DHHS/PHS/NIH) (Federal)
Funding Source: National Institutes of Health (Federal)
Sponsor: Department of Defense ? Philips Research North America (Prime) 44
Funding Source: Department of Defense (Federal)
PI: Bernard (Psych & Brain Sci); CoPI?s: Dormier (NURS), Engelen (HLKN), Sang (STATS), Alexander (Psych & Brain Sci)
PI: Fields (Psych & Brain Sciences); CoI: Engelen (HLKN)
Nut rit ion and Exercise in Crit ical Illness (The NEXIS Trial): A Random ized Trail of Com bined Cycle Ergom et ry and Am ino Acids in t he ICU
Sponsor: Co I National Institutes of Health (DHHS/PHS/NIH) (Federal)
Amount of Funding: $40,000
The Role of Adipose Tissue Est rogen Recept or Bet a in Obesit y Induced Insulin Resist ance
GRANTS&CONTRACTS
PI: Mehta (Ind & Syst Eng); Co I?s: Engelen (HLKN), Deutz (HLKN) Amount of Funding: $163,800
Amount of Funding: $756,559
Persist ent Readiness t hrough Early Predict ion (PREP) Co PI?s: Engelen (HLKN), Deutz (HLKN)
Mechanism s of Mot or Im pairm ent s w it h Obesit y in Males and Fem ales
Amount of Funding: $112,697 of $3,500,000
A Longit udinal Invest igat ion of t he Cerebellum in Adult hood: Anat om ical and Net w ork Changes, Mot or Funct ion, and Cognit ion
PI: Bernard (Neurosci), CoI: Domier (NURS), Engelen (HLKN), Sang (STATS), Alexander (Psych)
Tow ards Underst anding t he Relat ionship Bet w een Meals and Blood Biom arkers
Funding Source: National Science Foundation (Federal)
Sponsor: National Institutes of Health (DHHS/PHS/NIH) (Federal)
Nut rit ional Modulat ion t o Minim ize Resist ance Exercise Induced Met abolic Deregulat ions and Im prove Training Responsiveness in Chronic Obst ruct ive Pulm onary Disease
Funding Source: NIH National Heart, Lung, and Blood Institute (Federal)
PI: Newell Fugate (Vet Med & Biomed Sci); Co I: Deutz (HLKN) Amount of Funding: $11,600 of $275,915 total award
PI: Deutz with the University of Vermont
Funding Source: National Instititues of Health (DHHS/PHS/NIH) (Federal)
Amount of Funding: $28,026 of $3,049,115 award
Target ed Nut rit ional Approach t o Im prove Muscle Funct ion and Physical Act ivit y by Rest oring Met abolic Deregulat ions During Recovery from Sepsis
Amount of Funding: $81,200 of $595,977 award
PI?s: Deutz (HLKN), Engelen (HLKN), ten Have (HLKN)
Amount of Funding: $727,000
Amount of Funding: $1,770,586
PI: Engelen (HLKN)
East Carolina Universit y ? Com pounding for Dr Dohm PI: ten Have (HLKN) Amount of Funding: $60,000 of $258,379 awarded Sponsor: National Institutes of Health ? East Carolina University (Dohm) ESNL Longit udinal Invest igat ions of Sociocult ural and Behavioral Influences on Breast Cancer Survivorship PI: Wang (Georgetown U), Co PI: Chen (HLKN) Amount of Funding: $299,999 of $1,000,000 award Funding Source: National Instititues of Health (DHHS/PHS/NIH) (Federal) Status: ESNL will assist in data collection PRIVATEGRANTS CTRAL Effect s of Low Dose of Fish Oil (EPA+DHA) vs Com bined EPA+DHA and HMB Supplem ent at ion on Prot ein Met abolism , Muscle Mass and Funct ional Capacit y in Moderat e t o Severe COPD PI: Deutz (HLKN), CoPI?s: Engelen (HLKN) and Abbott Amount of Funding: $337,000 Funding Source: Abbott Laboratories (Private) Nanoscale Det erm inist ic Lat eral Displacem ent Technology PI: Deutz (HLKN) Amount of Funding: $30,400 Funding Source: International Business Machines (Private) HMB t o Reduce Prot ein Breakdow n in Sepsis PI: Deutz (HLKN) Amount of Funding: $139,000 Funding Source: Abbott Laboratories (Private) Role Of Met abolic Phenot yping, Changes In Gut Funct ion And The Response To A Meal To Explain The Variabilit y In Weight Loss Induced By Very Low Caloric Diet In (Morbidly) Obese Adult s PI: Simbo (CTRAL) with Engelen (HLKN ? Mentor) Amount of Funding: $20,000 Sponsor: European Society for Parenteral and Enteral Nutrition UC Davis ? Com pounding for Dr Chondronikola PI: ten Have (HLKN) Amount of Funding: $9,296 Sponsor: UCDavis Target ed Nut rit ional Approach t o Rest ore Met abolic Deregulat ions During Recovery from Sepsis as Assessed by Com prehensive Met abolic Phenot yping PI: ten Have (HLKN) Amount of Funding: $49,998 Sponsor: American Society for Parenteral and Enteral Nutrition (Private) 45
GRANTS&CONTRACTS HMB t o Reduce Prot ein Breakdow n in Sepsis Addit ional Analysis PIs: Deutz & ten Have (HLKN) Amount of Funding: $30,999 Sponsor: Abbott Laboratories The role of adipose t issue est rogen recept or bet a in obesit y induced insulin resist ance Co I: Deutz Sponsor: American Diabetes Association ESNL Effect s of Chrom ium , Phyllant hus em blica and Shilajit Supplem ent at ion (Crom inex®3+) and Phyllant hus em blica Fruit Ext ract (Capros? ) on Markers of Cardiovascular Healt h, Fit ness, and Weight Loss in Sedent ary and Overw eight Men and Wom en Init iat ing an Exercise Program PI: Kreider (HLKN); CoI?s: Earnest (HLKN), Murano (NFS, AGLS) Amount of Funding: $285,404 Funding Source: Natreon Status: In progress Effect s of Term inalia bellerica (Ayuric®) Supplem ent at ion on Uric Acid Levels and Markers of Cardiom et abolic Healt h in Individuals w it h Moderat ely Elevat ed but Non Medically Treat ed Hyperuricem ia PI: Kreider (HLKN); CoI?s: Earnest (HLKN), Murano (NFS, AGLS) Amount of Funding: $117,832 Funding Source: Natreon Status: Terminated due to low enrollment Efficacy of a Microalgae Ext ract PhaeoSOL on Opt im izing t he Benefit s of Overw eight and Moderat ely Obese Wom en Part icipat ing in an Exercise and Weight Managem ent Program PI: Kreider (HLKN) Amount of Funding: $201,606 Sponsor: MicroPhyt Status: In progress Pharm acokinet ic Analysis of Nut rient Absorpt ion from a Novel Liposom al Mult ivit am in/ Mineral Form ulat ion PI: Kreider (HLKN) Amount of Funding: $132,994 Sponsor: Nutraceutical Status: Data Analysis Im pact of Ast axant hin Supplem ent at ion on Markers of Cardiom et abolic Healt h and Tact ical Perform ance Am ong Firefight ers PI: Kreider (HLKN) Amount of Funding: $34,213 Sponsor: AstaReal Status: Planning Sim ple3 Relaxat ion Blend Proof of Concept St udy PI: Kreider (HLKN) Amount of Funding: $43,012 Sponsor: Nestles / Nature?s Bounty Status: Planning 46
PI: Kreider (HLKN) Amount of Funding: $202,942 Sponsor: Nutraceutical Corp Status: Pending final approval
Bioavailabilit y of Liposom al Magnesium Supplem ent at ion on Magnesium Levels and Markers of Healt h
PI: Kreider (HLKN); CoI?s: Earnest (HLKN), Murano (NFS, AGLS)
PI: Kreider (HLKN) Amount of Funding: $170,108 Sponsor: Nutraceutical Corp Status: Pending final approval Bioavailabilit y of Liposom al Iron Supplem ent at ion on Iron St at us and Markers of Healt h in Act ive Wom en
PI: Kreider (HLKN) Amount of Funding: $174,108 Sponsor: Nutraceutical Corp. Status: Pending final approval Effect s of Terminalia chebula fruit ext ract (AyuFlex) on percept ions and m arkers of joint funct ion in m en and w om en w it h m oderat e knee ost eoart hrit is (OA) Kreider (PI) Amount of Funding: $166,536 Sponsor: Natreon,
Inc Status: Slated as 4th study in multi year agreement INTERNALGRANTS AerospaceEngineering Ready t o Spin-up! A Mult idisciplinary Hum an-rat ed Short -Radius Cent rifuge Facilit y Co PI?s/Co I?s: Diaz Artiles (Aeorspace Engineering), Dunbar (Aerospace Engineering), Bloomfield (HLKN), Sheffield-Moore (HLKN), Kreider (HLKN), Zawieja (Medical Physiology), Bagher (Medical Physiology) Amount of Funding: $657,853. Funding Source: TAMU Research Development Fund Study Status: Planning Phase CTRAL The Effect s of Acut e Resist ance Exercise on Prot ein and Am ino Acid Met abolism in Chronic Obst ruct ive Pulm onary Disease PI: Engelen (HLKN) Amount of Funding: Internal funds Study Status: Completed 47
Amount of Funding: $128,218 Sponsor: Increnovo Status: Planning Bioavailabilit y of Liposom al Calcium on Calcium Levels and Markers of Bone St at us in Act ive Wom en
Effect s of Ashw aganha Supplem ent at ion on Cognit ive Funct ion and Mood
Effect s of Oral Nut rit ional Supplem ent and Acut e Resist ance Exercise in Chronic Obst ruct ive Pulm onary Disease PI: Engelen (HLKN) Amount of Funding: Internal funds Study Status: Completed Subcut aneous Microdialysis in Hum ans PI: Deutz (HLKN); CoI: Engelen (HLKN) Amount of Funding: $82,000 Funding Source: CTRAL Endowment/Residual Funds (Internal) Fiber Met abolism in Chronic Obst ruct ive Pulm onary Disease PI: Engelen; CoI: Deutz (HLKN) Amount of Funding: $15,000 Funding Source: CTRAL Endowment/Residual Funds (Internal) A prot ocol for Diet Tracking via Food Phot ography and Cont inuous Glucose Monit ors PI: Gutierrez Osuna (Comp Eng); CoI: Mortzavi (Comp Eng), Deutz (HLKN) Amount of Funding: $30,000 Funding Source: CTRAL Endowment/Residual Funds (Internal) Circuit Exercise Training on Subject s w it h Chronic Obst ruct ive Pulm onary Disease (COPD) PI: Deutz (HLKN); CoI: Engelen (HLKN) Amount of Funding: $100,000 Funding Source: CTRAL Endowment/Residual Funds (Internal) ESNL Nanoem ulsion Mediat ed Deliver of Cit rus Terpenoids for Neuroprot ect ion: A Pot ent ial Bioact ive Co PI?s: Kreider (HLKN), Patil (AGLS), Reddy (Medicine) Amount of Funding: $34,000 Funding Source: TAMU T3 Center/Lab: College of Medicine and Vegetable and Fruit Innovation Center (NFS) Com parison of Ingest ing a Food Bar Cont aining Whey Prot ein and Isom alt o Oligosaccharides t o Carbohydrat e on Perform ance and RecoveryPI?s: Kreider (HLKN); Grubic (HLKN Doctoral Student) Amount of Funding: $15,000 Funding Source: Kreider Professional Development & IDCFunds (Internal) Int erdisciplinary Advanced Robot ics Facilit y PI: Pagilla (Mech Eng); CoPI?s: Dimarco & Knap (Oceanography), Worthy (Geo Sci), Buchanan & Kreider (HLKN), A Thomasson (Ag Eng), Darrell, Hur (Eng Tech Ind Dist) Amount of Funding: $985,000 Funding Source: TAMU Research Development Fund Center/Lab: Mech Eng 48 GRANTS&CONTRACTS
HCRF Hum an Clinical Research Facilit y Core Facilit y Support PI?s: Kreider & Deutz (HLKN) Amount of Funding: $100,000 per year renewable up to 5 years (up to $500,000) Funding Source: TAMU Research Development Fund ? Recurring Fund (Internal) HLKNFACULTYGRANTSCONDUCTEDINHCRF The Role of Augm ent ed Feedback in t he Cont rol and Learning of Mot or Tasks in Individuals w it h Developm ent al Coordinat ion Disorder PI: Kennedy (HLKN) Amount of funding: $10,000 Funding Source: TAMU PESCA Grant Program Center/Lab: Neuromuscular Control Lab Int egrat ed Feedback and Augm ent ed Realit y for Individuals w it h Mot or Im pairm ent s PI: Kennedy (HLKN); CoPI?s: Hur (Engineering), Wang (Engineering) Amount of funding: $34,000 Funding Source: TAMU T3 Funding Center/Lab: Neuromuscular Control Lab Gut and Brain Plast icit y in Mild TBI follow ing Grow t h Horm one Therapy PI: Sheffield Moore Amount of funding: $201,228 Funding Source:University of Texas Medical Branch Galveston Moody Foundation Conducted by UTMB & ATM staff The Effect of Grow t h Horm one Releasing Horm one on Cognit ive Funct ion in Individuals w it h Mild Cognit ive Impairment and Healthy Controls PI: Sheffield Moore Amount of funding: $137,346 Funding Source:University of Texas Medical Branch Galveston Moody Foundation Conducted by UTMB & ATM staff 49
F Vestibular Precision at the Level of Perception, Eye Movements, Posture, and Neurons Neuroscience 2021,468, 282 320, doi:10 1016/j neuroscience 2021 05 028 Diaz Artiles, A ; Wang, Y; Davis, M M ; Abbott, R; Keller, N ; Kennedy, D M The Influence of Altered Gravity on Bimanual Coordination: Retention and Transfer Front Physiol 2021,12, 794705, doi:10 3389/fphys 2021 794705 Grgic, J; Pedisic, Z ; Saunders, B ; Artioli, GG ; Schoenfeld, B J; McKenna, M J; Bishop, D J; Kreider, RB ; Stout, JR; Kalman, D S; Arent, SM ; VanDusseldorp, TA ; Lopez, H L ; Ziegenfuss, TN ; Burke, L M ; Antonio, J; Campbell, B I International Society of Sports Nutrition position stand: sodium bicarbonate and exercise performance JInt Soc SportsNutr 2021,18, 61, doi:10 1186/s12970 021 00458 w 50 2021PUBLICATIONS
Bonilla, D A ; Moreno, Y; Rawson, ES; Forero, D A ; Stout, JR; Kerksick, CM ; Roberts, M D ; Kreider, RB A Convergent Functional Genomics Analysis to Identify Biological Regulators Mediating Effects of Creatine Supplementation Nutrients2021,13, doi:10 3390/nu13082521 Bonilla, D A ; Pérez Idárraga, A ; Odriozola Martínez, A ; Kreider, RB The 4R?s framework of nutritional strategies for post exercise recovery: a review with emphasis on new generation of carbohydrates Int JEnviron ResPublicHealth 2021,18, 103 Cannataro, R; Carbone, L ; Petro, JL ; Cione, E; Vargas, S; Angulo, H ; Forero, D A ; Odriozola Martinez, A ; Kreider, RB ; Bonilla, D A Sarcopenia: Etiology, Nutritional Approaches, and miRNAs Int JMol Sci 2021,22, doi:10 3390/ijms22189724 Cardoza, L.A.; Yanez, C.A.; Moreno Jimenez, J.; Beltran Ahumada, C.; Kreider, R.B.; Bonilla, D.A. Joint mobility in physical education majors: A hierarchical clustering Analysis JPhysEducSport 2021,21, 2752 ? 2761 de la Piscina Viúdez, XR; Álvarez Herms, J; Bonilla, D A ; Castañeda Babarro, A ; Larruskain Zabala, J; Díaz Ramírez, J; Ahmetov, I I ; Martínez Ascensión, A K , RB ; Odriozola Martínez, A Putative role of MCT1 rs1049434 polymorphism in high intensity endurance performance: Concept and basis to understand possible individualization stimulus.Sports(Basel) 2021,9, 143. Diaz Artiles, A ; Karmali,
The following overviews articles have been published from research conducted and/or emanating from resident PI?s housed in the HCRF and/or commissioned by fee for service sponsors to publish work conducted in the HCRF in 2021 (CTRAL Publications are listed separately. This list is provided so potential collaborators, sponsors, and/or funding agencies can get a sense of the type and quality of work being conducted by PI?s housed in the HCRF and/or as a result of FFS sponsors work For a more comprehensive list, see Refereed Research Presentations or Resident PI's center/lab or Google Scholar pages Antonio, J; Candow, DG ; Forbes, SC; Gualano, B ; Jagim, A R; Kreider, RB ; Rawson, ES; Smith Ryan, A E; VanDusseldorp, TA ; Willoughby, D S; Ziegenfuss, TN Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?JInt SocSportsNutr 2021,18, 13, doi:10 1186/s12970 021 00412 w Bagheri, R; Hooshmand Moghadam, B ; Ashtary Larky, D ; Forbes, SC; Candow, DG ; Galpin, A J; Eskandari, M ; Kreider, RB ; Wong, A Whole Egg Vs Egg White Ingestion During 12 weeks of Resistance Training in Trained Young Males: A Randomized Controlled Trial JStrength Cond Res2021,35, 411 419, doi:10 1519/JSC0000000000003922 Belobrajdic, B ; Melone, K ; Diaz Artiles, A Planetary extravehicular activity (EVA) risk mitigation strategies for long duration space missions NPJMicrogravity 2021,7, 16, doi:10 1038/s41526 021 00144 w Bonilla, D A ; Kreider, RB ; Petro, JL ; Romance, R; Garcia Sillero, M ; Benitez Porres, J; Vargas Molina, S Creatine Enhances the Effects of Cluster Set Resistance Training on Lower Limb Body Composition and Strength in Resistance Trained Men: A Pilot Study Nutrients2021,13, doi:10 3390/nu13072303 Bonilla, D A ; Kreider, RB ; Stout, JR; Forero, D A ; Kerksick, CM ; Roberts, M D ; Rawson, ES Metabolic Basis of Creatine in Health and Disease: A Bioinformatics Assisted Review Nutrients2021,13, doi:10 3390/nu13041238 Bonilla, D A ; Moreno, Y; Gho, C; Petro, JL ; Odriozola Martinez, A ; Kreider, RB Effects of Ashwagandha (Withania somnifera) on Physical Performance: Systematic Review and Bayesian Meta Analysis.JFunct Morphol Kinesiol 2021,6, doi:10 3390/jfmk6010020
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Kluis, L ; Diaz Artiles, A the of the ,7, 46, doi:10.1038/s41526 Kluis, L.; Keller, N.; Bai, H.; Iyengar, N.; Shepherd, R.; Diaz Artiles, A. Metabolic Cost During Ambulation Using Robotic Actuation. 2021,92, 570 578, doi:10.3357/AMHP.5754.2021. RB Exercise and Nutritional Strategies to Weight Loss: A Review and ComplementaryMedicine 2021,6, 19, doi:doi:10 21926/obm 2104041 Kreider, RB ; Stout, JR Creatine in Health and Disease Nutrients 2021,13, doi:10 3390/nu13020447 - Minaei, S; Jourkesh, M ; Kreider, RB ; Forbes, SC; Souza-Junior, TP; McAnulty, SR; Kalman, D CYP1A2 Genotype Polymorphism Influences the Effect of Caffeine on Anaerobic Performance in Males J Sport Nutr ExercMetab 2021, 1 6, doi:10 1123/ijsnem 2021 0090 Ramirez de la Piscina Viudez, X; Alvarez Herms, J; Bonilla, D A ; Castaneda Babarro, A ; Larruskain, J; Diaz Ramirez, J; Ahmetov, II; Martinez Ascension, A ; Kreider, RB ; Odriozola Martinez, A Putative Role of MCT1 rs1049434 Polymorphism in High Intensity Endurance Performance: Concept and Basis to Understand Possible Individualization Stimulus.Sports(Basel) 2021,9, doi:10.3390/sports9100143.
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Sowinski, R; Gonzalez, D ; Xing, D ; Yoo, C; Jenkins, V; Nottingham, K ; Dickerson, B ; Humphries, M ; Leonard, M ; Ko, J; Faries, M ; Kephart, W; Rasmussen, CJ; Kreider, RB Effects of Inositol Enhanced Bonded Arginine Silicate Ingestion on Cognitive and Executive Function in Gamers Nutrients 2021,13, doi:10 3390/nu13113758 Sowinski, RJ; Grubic, TJ; Dalton, RL ; Schlaffer, J; Reyes Elrod, AG ; Jenkins, VM ; Williamson, S; Rasmussen, C; Murano, PS; Earnest, CP; Kreider, RB An Examination of a Novel Weight Loss Supplement on Anthropometry and Indices of Cardiovascular Disease Risk JDiet Suppl 2021,18, 478 506, doi:10 1080/19390211 2020 1786207 Vargas Molina, S; Carbone, L ; Romance, R; Petro, JL ; Schoenfeld, B J; Kreider, RB ; Bonilla, D A ; Benitez Porres, J. Effects of a low carbohydrate ketogenic diet on health parameters in resistance trained women.Eur JAppl Physiol 2021,121, 2349 2359, doi:10.1007/s00421 021 04707 3. Wax, B.; Kerksick, C.M.; Jagim, A.R.; Mayo, J.J.; Lyons, B.C.; Kreider, R.B. Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations Nutrients 2021,13, doi:10 3390/nu13061915 Whittle, RS; Diaz Artiles, A Modeling individual differences in cardiovascular response to gravitational stress using a sensitivity analysis JAppl Physiol (1985) 2021,130, 1983 2001, doi:10 1152/japplphysiol 00727 2020 Whittle, RS; Stapleton, L M ; Petersen, LG ; Diaz Artiles, A Indirect measurement of absolute cardiac output during exercise in simulated altered gravity is highly dependent on the method JClin Monit Comput 2021, doi:10 1007/s10877 021 00769 y Wright, T; Davis, RW; Pearson, H C; Murray, M ; Sheffield Moore, M Skeletal muscle thermogenesis enables aquatic life in the smallest marine mammal Science 2021,373, 223 225, doi:10 1126/science D.; Yoo, C.; Gonzalez, D.; Jenkins, V.; Nottingham, K.; Dickerson, B.; Leonard, M.; Ko, J.; Faries, M.; Kephart, W.; Purpura, M.; Jager, R.; Wells, S.D.; Sowinski, R.; Rasmussen, C.J.; Kreider, R.B. Dose Response of Paraxanthine on Cognitive Function: A Double Blind, Placebo Controlled, Crossover Trial Nutrients ,13, doi:10 3390/nu13124478 C; Xing, D Gonzalez, D Jenkins, V; Nottingham, K ; Dickerson, B ; Leonard, M ; Ko, J; Faries, M ; Kephart, W; Purpura, M ; Jager, R; Wells, SD ; Sowinski, R; Rasmussen, CJ; Kreider, RB Acute Paraxanthine Ingestion and Short-Term Memory Helps Sustain in a Double-Blind, Crossover ,13, doi:10 3390/nu13113980
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