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Medical Imaging International

New PET/CT System Addresses Clinical Indications in Oncology, Neurology, and Cardiology new Positron Emission Tomography/Computed Tomography (PET/ CT) system enables clinicians to serve a wide range of patients and move into new service areas using commercially available PET tracers. The new system automates previously manual tasks enabling users to address more indications in oncology, neurology and cardiology. The system uses 4-mm Lutetium Oxyorthosilicate (LSO) crystals to provide rapid scintillation with a high light output, and the lowest possible achievable dose to visualize small lesions. The Siemens Healthcare (Erlangen, Germany; www.healthcare.siemens.com) Biograph Horizon system has features that help automate tasks, streamline workflow, and increase productivity and can perform a scan in less than five minutes. Image reconstruction occurs in parallel to acquisition and is ready 30 seconds after the scan. The QuantiQC feature runs overnight calibration and quality control procedures. The Biograph Horizon also features the syngo.via Molecular Imaging Workplace image processing solution for measurements and reporting. Other features include automated tools to visualize diagnostic information in real time, automate prefetching, preprocessing, and display comparison of previous findings. The system also features Siemens ALPHA technology for automatic registration, and EQ/PET that can calculate precise changes in tumor uptake.

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Cover Image: Courtesy of Carestream Health Dan Gueron Publisher Andrew Deutsch News Editor Joseph Ciprut Assistant Editor Brenda Silva New Products Editor Theresa Herman Regional Director Dr. Jutta Ciolek Regional Director

Steve Holmes, Sales Director, Siemens Healthcare, said, “At a time when there is a demand to drive down cost while enhancing productivity, Siemens is well placed to support with technology capable of improving care pathways and maximizing investments. The Biograph Horizon provides a cost-effective PET/CT imaging solution that does not compromise on quality. As our smallest PET/CT system, it offers low power requirements and a small footprint to ensure reduced operating and maintenance costs, with the flexibility to meet expanding clinical needs.” Image: The versatile Biograph Horizon PET/CT system offers premium performance at cost-effective ownership (Photo courtesy of Siemens Healthcare).

Brain Imaging Technology Could Help Study Parkinson’s Disease portable imaging device has identified differences in brain activation patterns associated with postural stability in people with Parkinsonian syndromes, according to a new study. Researchers at Drexel University (Philadelphia, PA, USA; www.drexel.edu) and Yeshiva University (YU; New York, NY, USA; www.yu.edu) used a portable functional near infrared spectroscopy (fNIRs) device as a direct online cortical probe to compare neural activation patterns in the prefrontal cortex, postural stability, and their respective interactions, in 269 older adults (mean 76 years, 56% women) without dementia. Of these, 26 patients had Parkinsonian syndromes; 117 had mild Parkinsonian signs; and 127 were healthy older adults who served as controls. The participants were asked to stand upright and count silently for ten seconds while changes in oxygenated hemoglobin levels over prefrontal cortex were measured using fNIRs. The researchers simultaneously evaluated postural stability with center of pressure velocity data recorded on an instrumented walkway. The results showed that when compared to healthy controls and patients with mild Parkinsonian signs, the patients with Parkinsonian syndromes demonstrated significantly higher prefrontal

oxygenation levels to maintain postural stability. The study was published in the November 6, 2015, issue of Brain Research. “Postural instability is a major risk factor for older adults. This initial study allowed us to measure brain activity in real time, in a realistic setting. It shows that there are indeed differences in the prefrontal cortex of healthy and Parkinsonian syndrome patients,” said study coauthor biomedical engineer Meltem Izzetoglu, PhD, of Drexel University. “If we can monitor the cognitive component of staying balanced, then this could eventually lead to better treatment options for people with Parkinsonian syndromes or even Parkinson’s disease.” The prefrontal cortex is the brain region considered to be in charge of the orchestration of thoughts and actions in accordance with internal goals, and is responsible for higher-level processing, such as memory, attention, problem solving, and decision-making. When a person is learning a new skill, for instance, neural activity is greater in this region. Increasing evidence shows that in Parkinson‘s disease, profound dopamine depletion not only occurs in the striatum of the brain, but also in the prefrontal cortex, and this may be associated with cognitive and motor deficits.

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Medical Imaging International March-April/2016