PrescriptionScreeningProcessAnalysis
Background
Pre-prescriptionstudiesareanimportantprerequisiteforthe developmentofformulationprescribingprocess,whichprovidesan importantbasisfortheassessmentofthedrug-formingpropertiesof compounds,therouteofadministrationanddosageformselectionof products,thedesignofprescribingprocessandqualitycontrol,andis asolidfoundationforthedevelopmentofsafe,effectiveand quality-controlleddrugs.Pre-prescriptionformulationanalysisisthe analysisofthephysicalandchemicalpropertiesofadrugwhenused aloneorincombinationwithexcipients.Earlypredictionofthese propertieswillyieldinformationusefultoformulatorsindeveloping stableandsafedosageformswithgoodbioavailability.
Systematicpreformulationstudieswilleffectivelyguidethedesignof clinicalformulationsofdrugsandthedevelopmentofsafeand effective,stableandcontrolled,easy-to-useformulations.
DissolutionRateTest
SolubilityAnalysis
AdhesionTest
CrystallinityDetermination
ParticleSizeAnalysis
PowderFlowabilityTest
DeterminationofContactAngleofPharmaceuticalExcipients
ConePenetrationTest
SolidDensityTest
BulkDensityandCompactionDensityTest
TabletHardnessTest
AmorphousContentDetermination
HygroscopicityEvaluation
API-ExcipientCompatibility
Source: https://www.formulationbio.com/prescription-screening-process-an alysis.html