Outstanding St. Louis Scientists Awards 2016 program

The Academy of Science - St. Louis presents

22nd Annual Outstanding St. Louis Scientists Awards Thursday, April 7, 2016

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We Believe

• The children we engage in science and technology today are the critical thinkers and problem solvers of the future.

• The decisions facing our world require a scientifically literate citizenry, informed by those with expertise in science and technology.

• The St. Louis region is a brain trust of researchers, investigators, explorers, and science advocates–dedicated to fostering the next generation of STEM leaders and advocates.

We Know

• That by 8th grade, children have determined if they have a place in science and technology. By connecting them to STEM professionals who share the rewards of their efforts, we are building the workforce of the future.

• That communicating complex science and technology ideas to the public can be effectively accomplished through stories, accessible outreach, and citizen-science opportunities.

• That children learn science inquiry through hands-on, relevant, project-based experiences.

• That 87% of middle school students, after engaging in Academy career explorations with professionals in science and technology, report a better understanding of why it is important to take math and science; and 74% state that the experience inspired them to want to find out more about future careers in STEM fields.

We Trust

• In the power of collaboration and interdisciplinary ideas and effort.

• In an engaged community of advocates of the community outreach initiatives of the Academy of Science.

• In the value of a uniquely independent and community-supported organization, true to its 1856 mission, “Promoting the understanding and appreciation of science.”

Mary Burke

Chief Executive Officer

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Our Mission

The Academy seeks to advance the public understanding of science and promote interest in the sciences to students and adults through accessible, year-round seminars and educational initiatives.

connecting science and the community since 1856速

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Dinner Support The Academy of Science – St. Louis wishes to thank the following sponsors for their generous contributions.

Proceeds from the Awards Dinner support programs of the Junior Academy of Science.

For information, please visit our website, www.academyofsciencestl.org.

Platinum Plus Sponsors Monsanto Company Washington University School of Medicine in St. Louis Department of Developmental Biology Platinum Sponsors Mary ville University Gold Sponsors Nestle´ Purina Petcare Silver Sponsors The Boeing Company Mallinckrodt Pharmaceuticals MilliporeSigma Missouri Botanical Garden Saint Louis University School of Medicine Department of Biochemistry and Molecular Biology Saint Louis University School of Medicine Department of Pharmacological and Physiological Sciences Saint Louis Zoo SunEdison Semiconductor Thompson Coburn LLP

University of Missouri – Columbia Washington University in St. Louis Department of Chemistry Washington University School of Medicine in St. Louis Washington University School of Medicine in St. Louis Department of Genetics Patrons Kenneth Mares, Ph.D. Gifts in Honor or Memory Malika Anagnostopoulos in honor of Constantine Anagnostopoulos, Ph.D. Pamela K. Bruns, CRNA and Kenneth R. Smith, M.D. in honor of Junior Academy students William H. Danforth, M.D. in honor of Junior Academy Students S. Allen Heininger, D.Sc. and Margot Heininger in honor of Junior Academy students Lesley Knowles in memory of William S. Knowles, Ph.D.

Media Sponsors

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Evening Agenda

welcome | award presenters Benjamin H. Hulsey President, Academy of Science – St. Louis Mary E. Burke Chief Executive Officer, Academy of Science – St. Louis

dinner educator awards Monsanto Company Science Teacher of the Year Patricia Henry – Confluence Academy Old North Presented by: Al Mitchell, Monsanto Company SunEdison Science Teacher of the Year Kim Rois – Kennard Classical Junior Academy Presented by: Carissima Hudson, Ph.D., SunEdison Semiconductor

next generation awards Academy of Science - St. Louis Science Fair: Honors Division Awards 1st Place – Monica Malone, Horton Watkins Ladue High School 2nd Place – Haran Kumar, Parkway West High School 3rd Place – Sai Allu, Lafayette Senior High School

outstanding st. louis scientists presentations Congratulations!

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Science Educator Award Kyra N. Krakos, Ph.D.

Assistant Professor of Biology, Maryville University Dr. Krakos is devoted to educating students and the community about botany.

Her dedication to learning extends beyond the classroom, as evidenced by her research and work. Dr. Krakos’ lab studies plant reproductive ecology and ecosystem health, with a focus on the invasive honeysuckle plant. Most recently Dr. Krakos invited art students to join science students in her lab, and all brought their creative problem-solving skills to bear on the honeysuckle issue.

As part of the interdisciplinary approach, they experimented with honeysuckle wood and fiber to create, exhibit and sell art and handcrafted products made from honeysuckle. The Bauhaus Botany exhibit brought people from throughout the community to a first-class exhibit and garnered the students a speaking engagement with the Missouri Native Plant Society. Dr. Krakos is the co-director of the Missouri Region Junior Science and

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Engineering for Humanity Symposium hosted at Maryville. The two-day STEM research event provides our state’s high school students the opportunity to network with other students and community scientists, share original research, and compete for prizes and scholarships at the national symposium. At the Missouri Botanical Garden, Dr. Krakos founded and codirected the Students at the Garden program, a program that enriches the undergraduate experience of many students.

Her summer research lab takes teams of undergraduates to field sites at Shaw Nature Reserve and in Wyoming, Colorado and Texas. Dr. Krakos and the undergraduates in her lab attend and present their research at the Botanical Society of America national meetings, now five years and counting. In 2015, Dr. Krakos gave a TEDx talk titled “Plants, Pollinators and People: A Love Story.”

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Innovation Award

Tiffani D. Eisenhauer, Ph.D. Principal Formulations Scientist, Mallinckrodt Pharmaceuticals

Dr. Eisenhauer’s innovation in product design and formulation, manufacturing processing, and testing methodology demonstrates the breadth and depth of her technical understanding.

As a lead scientist at Mallinckrodt, Dr. Eisenhauer’s most significant achievement thus far is creating a unique extended-release, oral analgesic product containing a combination of acetaminophen and oxycodone, which was recently approved by the U.S. Food and Drug Administration.

The importance of Dr. Eisenhauer’s work is to help combat the widespread problem of prescription opiate abuse in the United States. According to recent data from the Centers for Disease Control, in 2012 prescription opiate overdoses accounted for

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more than 15,000 deaths and tens of thousands of emergency room visits.

This is more than the number of deaths from overdoses of illegal heroin and cocaine combined. The need for opiate analgesics that deter misuse and abuse is a priority.

With that in mind, Mallinckrodt looked to Dr. Eisenhauer for her formulation expertise. The goal was to create an extended-release product that would successfully treat acute pain over a ten- to twelve-hour period and resist common forms of tampering and abuse. By creating an opiate-based analgesic formulation with abusedeterrent properties, Eisenhauer and her team have added to the small number of products that may help reduce prescription opiate abuse.

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Innovation Award Gary J. Patti, Ph.D.

Associate Professor, Department of Chemistry, Washington University in St. Louis Dr. Patti has contributed to the development of foundational technologies in metabolomics that are being used by scientists worldwide. His pioneering work has enabled the first complete annotation of the tens of thousands of signals detected in metabolomic analysis of biological samples.

By using an elegant experimental technique his laboratory developed, Dr. Patti is now able to quantitate the number of unknown metabolites detected in metabolomic experiments. Instead of thousands of metabolomic signals corresponding to unknown metabolites as was previously believed, he has shown that it is only hundreds. Among his most impressive accomplishments has been the application of these untargeted metabolomic technologies to discover a painmediating metabolite, which was

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not previously known to occur naturally in biological systems. He has demonstrated that this metabolite is increased in patients suffering from chronic neuropathic pain, and that symptoms can be ameliorated by inhibiting its production.

Inhibitor drugs are currently being explored as potential therapeutics. In addition to his innovation in the laboratory, Dr. Patti has also demonstrated innovation in the classroom, where he has developed interactive digital resources for students to learn biochemistry. As a result of his success, Dr. Patti has been recognized with some of the most prestigious national awards, including the Alfred P. Sloan Fellowship, the Camille Dreyfus Teacher-Scholar Award, and the Pew Scholar Award in the Biomedical Sciences.

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George Engelmann Interdisciplinary Award Yuanlong Pan, BVM, Ph.D.

Senior Research Scientist, Nestle´ Purina Petcare, Nestle´ Research Center – St. Louis Dr. Pan’s highest achievements have been focused in the field of cognitive health and neuroscience.

The most recent achievement was his discovery research that identified and developed a blend of nutrients that support the structure and function of the brain to promote neurogenesis.

This discovery is a major advancement in cognitive health in mammals. In addition, his research discovered the beneficial effects of medium chain triglycerides on brain function in dogs by providing an additional source of energy. Dr. Pan’s research and collaborations have resulted in ten patents and fortyone patent applications. His work has led to commercialization of five new pet foods to help aging dogs stay active and healthy by providing an additional source of energy for the brain. These

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scientific contributions are of great importance for veterinary medicine and nutrition, but also for human physiology and medicine.

Several of his recent publications within the past five years have landmark value for the following reasons: use translatable behavioral tests to measure executive function – an ability that declines in humans afflicted by cognitive decline in mild cognitive impairment and in Alzheimer’s disease; and these long-term studies (one year or longer) have relevance for human treatment. The studies by Dr. Pan are using serum biomarkers, metabolomics, and MRI imaging of the brain white and gray matter – all fully translatable to humans and thus carry a value far beyond veterinary medicine and companion animals.

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George Engelmann Interdisciplinary Award Gary D. Stormo, Ph.D.

Joseph Erlanger Professor, Department of Genetics, Center for Genome Sciences, Washington University School of Medicine in St. Louis Dr. Stormo is a pioneer in bioinformatics and genomics, and a leading figure in the development of algorithms for data mining of DNA sequence data. His work has contributed to the understanding of regulation of gene expression and proteinDNA interactions. His work has impacted both the fields of experimental and computational molecular biology, but is also highly interdisciplinary beyond the fields of biology. He has been an invited speaker at conferences in the fields of math, statistics, computer science, chemistry and physics; his research has been supported by the National Institutes of Health and the Department of Energy; he has published more than 190 scientific papers; and he is the author of the book Introduction to Protein-DNA Interactions: Structure, Thermodynamics and

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Bioinformatics.

Dr. Stormo has published papers with colleagues in fourteen different internal departments, and with fifteen different universities.

Dr. Stormo has served on the International Advisory Committee on Nucleic Acid Sequence Databases and on several NIH committees.

He was an early advisor to the National Library of Medicine as GenBank was being designed and implemented. He was Executive Editor of Bioinformatics, Deputy Executive Editor of Public Library of Science: Computational Biology, and an Editor for Current Protocols in Bioinformatics. He is a Fellow of the International Society for Computational Biology and the American College of Medical Informatics.

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Fellows Award

James A. Birchler, Ph.D.

Curators’ Professor, Division of Biological Sciences, University of Missouri – Columbia

Dr. Birchler has made experimental and theoretical contributions to genetic studies of both maize and Drosophila systems. His studies have provided insight into gene silencing, centromere epigenetics, heterosis, dosage compensation, aneuploidy syndromes, and the evolutionary fate of gene duplications. His chromosome painting and single gene localization protocols have been adapted to several other plant species by many chromosome

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biologists around the world. Dr. Birchler holds two U.S. patents and four international patents for his plant chromosome technologies.

He has authored over 250 scientific articles. He is a fellow of the American Association for the Advancement of Science and the National Academy of Inventors, an Einstein Professor of the Chinese Academy of Sciences, and a member of the National Academy of Sciences.

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Fellows Award

Thomas P. Burris, Ph.D.

William Beaumont Professor and Chair, Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine

Dr. Burris is an internationally recognized leader in the fields of nuclear receptor biochemistry and pharmacology. Dr. Burris’ research focuses on a particular class of proteins, nuclear receptors, which regulate myriad physiological functions in humans. Dr. Burris has identified the physiological ligands for several nuclear receptors, as well as developed first-in-class synthetic ligands that target these receptors. He has demonstrated

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that many of these novel synthetic ligands are potential drugs to treat diseases, including heart disease, diabetes, behavioral disorders, autoimmunity and cancer. Dr. Burris has published more than 130 manuscripts, and these studies have been cited more than 7,500 times. His scientific achievements have been recognized by election to fellowship in the American Association for the Advancement of Science and the American Heart Association.

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Fellows Award

Lilianna Solnica-Krezel, Ph.D.

Alan A. and Edith L. Wolff Distinguished Professor and Head, Department of Developmental Biology, Washington University School of Medicine in St. Louis Dr. SolnicaKrezel has devoted her career to understanding the mysterious processes that govern how a mass of embryonic cells becomes a recognizable organism. Her pioneering work as a geneticist and developmental biologist laid the foundation for modern zebrafish research, as she studies genetic mechanisms underlying early embryonic development. She is an expert in using the zebrafish model for functional annotation of vertebrate genes, having established methods of chemical mutagenesis. She coordinated the first large-scale genetic screens that revealed thousands of mutations affecting zebrafish development, from gastrulation through vascular, neural, craniofacial, eye and ear development. She also identified or generated mutations that model human birth defects and diseases, such as holoprosencephaly, tuberous sclerosis complex, and scoliosis. In 1996 she established

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her own zebrafish laboratory at Vanderbilt University, where she became Martha Rivers Ingram Professor of Developmental Genetics. In 2010 she moved to St. Louis to become the first woman to lead a department at the Washington University School of Medicine. She is Developmental Biology section head for Faculty of 1000, serves on editorial boards of Developmental Biology, Development and Developmental Cell, and served as Associate Editor at Developmental Dynamics. She serves on the Edward Mallinckrodt Jr. Foundation Board of Directors and the Board of Scientific Directors of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Intramural Program. Dr. SolnicaKrezel effectively mentors the next generation of scientists in her own lab, trainees and junior faculty throughout the department and Washington University as a whole.

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James B. Eads Award Rob Mitra, Ph.D.

Alvin Goldfarb Distinguished Professor of Computational Biology, Associate Professor, Department of Genetics, Washington University School of Medicine in St. Louis Dr. Mitra pioneered the development of novel technologies that overcome long-standing barriers in biological research. He has developed innovative sequencing and genomic data analysis technologies, allowing him to investigate the hypothesis that common diseases may be explained in large part by the cumulative effect of many genetic variants that occur rarely in the population. He has used this approach to investigate nicotine dependence, neonatal respiratory distress syndrome and cardiovascular failure. Dr. Mitra created a revolutionary new way

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to identify transcription factor binding sites using transposon “calling cards.� These transposons are used to make the binding of a transcription factor to its target site, which, when used with modern sequencing methods, greatly improves the ability to identify transcription factor binding sites over previous technologies. This technology has particular utility in the study of how transcription factors direct cell fate decisions. Dr. Mitra has also established methods for single molecule proteomic studies, a truly unprecedented effort.

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Trustees Award

Sherri M. Brown, Ph.D.

Vice President of Science Strategy Monsanto Company Dr. Brown has been an innovative leader throughout her career in science and agriculture. She is the Chair of the STEM Food and Agriculture Council, a new initiative of AG corporate and university programs from around the country that aim at raising awareness for young people to enter careers in food and agriculture. The commercial development of biotech corn would not have been possible without Dr. Brown’s critical innovations. In the early 1990s, she identified the best coding sequences, chloroplast transit peptide systems, promoters to create glyphosate-tolerant and insect-protected corn, which are grown by millions of farmers today. Dr. Brown is an innovator in utilizing scientific talent.

Understanding that mentoring is critical to the practice of good science, Dr. Brown developed and led the novel Technology

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Mentoring Program, designed to enable scientists, especially diverse scientists, to develop the soft skills and relationships to succeed in scientific leadership roles. As a testament to its success, the Technology Mentoring Program is now in its thirteenth year at Monsanto.

Today, she is a champion of STEM and contributions of women in agriculture. She leads the Monsanto Fellows program, which recognizes and utilizes the company’s top scientists, and has been a driving force for the formation of Women in Science Exchange, Monsanto’s new women’s network. Dr. Brown can be credited not only with individual discoveries, but also for leading teams that have advanced scientific innovations from the lab bench through complex product development processes, resulting in successful commercialization.

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Science Leadership Award Henry C. Foley, Ph.D.

Interim Chancellor of the University of Missouri – Columbia

Leading up to his appointment as Interim Chancellor, Dr. Foley served as Executive Vice President of Academic Affairs, Research and Economic Development of the University of Missouri System and Senior Vice Chancellor for Research, Graduate Studies, and Economic Development at the University of Missouri – Columbia. He is a tenured professor of chemistry at University of Missouri and is a tenured professor of chemical and biochemical engineering at the Missouri University of Science and Technology. He has strongly endorsed excellence and

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cooperation among the four University of Missouri campuses.

While holding numerous administrative and leadership posts throughout his entire career, he has remained a committed scientist.

He and his students have published more than 120 scientific papers, and he has been named as inventor on sixteen issued United States patents. Dr. Foley was elected Fellow of the National Academy of Inventors in 2013 and was recently made a Fellow of the Industrial & Engineering Division of the American Chemical Society.

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Peter H. Raven Lifetime Achievement Award Cheryl Asa, Ph.D.

Director of Research and Director of Association of Zoos and Aquariums Reproductive Management Center, Saint Louis Zoo Dr. Asa has devoted her career to the conservation of Earth’s biodiversity. A highly respected scientist with over 150 peerreviewed articles on a multitude of topics, her sound research has contributed to the recovery of a wide range of species, both in zoos and the wild. An example of her efforts is the island fox (Urocyon littoralis).

When wild populations declined to just fifteen individuals on two of the California Channel Islands where the foxes were endemic, Dr. Asa was enlisted by the National Park Service to assist with intense recovery actions. Listed as endangered in 2004, island foxes had never been in captivity before, but studies conducted by Dr. Asa ultimately led to breeding enough individuals that release back into the wild was possible.

This February, the U.S. Fish and Wildlife Service announced that the island fox would be removed from the endangered species

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list—the fastest successful recovery of any mammal listed under the Endangered Species Act. Her colleagues at the NPS stated that the conservation of the island fox would not have been possible without her research.

Dr. Asa was a pioneer of the development of non-invasive techniques to evaluate reproductive conditions in wildlife, and she is the world’s foremost expert on wildlife contraception.

In recent years, she has led international research teams to improve species sustainability by studying the effects of mate choice, infertility, and the use of stored gametes for genetic augmentation. These initiatives have major implications for animal well-being, reproductive success, maintenance of genetic variation, and ultimately, the long-term sustainability of animal populations.

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Past Awardees The Peter H. Raven Lifetime Achievement Award — recognizes a distinguished career of service in science, engineering, or technology.

2015 – Steven L. Teitelbaum, M.D. 2014 – John Edward Heuser, M.D. 2013 – John C. Morris, M.D. 2012 – Jeffrey I. Gordon, M.D. 2011 – Marcus E. Raichele, M.D. 2010 – Roger N. Beachy, Ph.D. 2009 – Carl Frieden, Ph.D. Eduardo Slatopolsky, M.D. 2008 – William S. Knowles, Ph.D. 2007 – Philip D. Stahl, Ph.D. David C. Van Essen, Ph.D. 2006 – Lee Nelken Robins, Ph.D. 2005 – Teresa J. Vietti, M.D. 2004 – Brian J. Mitchell, Ph.D. 2003 – Ira J. Hirsh, Ph.D. Nobuo Suga, Ph.D. 2002 – Maurice Green, Ph.D. Patty Jo Watson, Ph.D. 2001 – Jerome R. Cox, Jr., Sc.D. Robert W. Murray, Ph.D. 2000 – Philip Needleman, Ph.D. Robert H. Waterston, M.D., Ph.D. 1999 – Frank E. Moss, Ph.D. William S. Sly, M.D. 1998 – Louis V. Avioli, M.D. Leonard Berg, M.D. 1997 – Paul E. Lacy, M.D., Ph.D. Robert M. Walker, Ph.D. 1996 – John Olney, M.D. 1995 – Michel Ter-Pogossian, Ph.D. The Science Leadership Award — recognizes a distinguished individual – not necessarily a scientist – or organization that has played an important leadership role in the development of science and scientists in the St. Louis region.

2015 – Cortex Innovation Community Ralph S. Quatrano, Ph.D. 2014 – Novus International, Inc. Robert T. Fraley, Ph.D. 2013 – Nestle Purina PetCare Karen Seibert, Ph.D. 2012 – James S. McDonnell Foundation Larry J. Shapiro, M.D.

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2011 – Emerson Timothy Eberlein, M.D. 2010 – Missouri Botanical Garden M. Carolyn Baum, Ph.D., OTR 2009 – The Boeing Company William A. Peck, M.D. 2008 – Charles Kilo, M.D., F.A.C.P., F.A.C.E. Monsanto Company 2007 – William (Bill) Danforth, M.D. Sigma-Aldrich Corporation The James B. Eads Award — recognizes a distinguished individual for outstanding achievement in engineering or technology.

2015 – Babu Chalamala, Ph.D. Charles M. Hohenberg, Ph.D. 2014 – Charles L. Armstrong, Ph.D. Lihong Wang, Ph.D. 2013 – George W. Gokel, Ph.D. Gregory Yablonsky, Ph.D. 2012 – Kevin L. Deppermann Stuart A. Solin, Ph.D. 2011 – Ettigounder Ponnusamy, Ph.D. Alexander Rubin, Ph.D. 2010 – David A. Fischhoff, Ph.D. Stephen R. Padgette, Ph.D. 2009 – Ramesh K. Agarwal, Ph.D. 2008 – Sherman J. Silber, M.D., F.A.C.S. 2006 – Robert B. Horsch, Ph.D. 2005 – Krishnan K. Sankaran, Ph.D. 2004 – Rudolph N. Yurkovich 2003 – Donald P. Ames, Ph.D. 2002 – Richard E. Pinckert, Ph.D. Jonathan S. Turner, Ph.D. 2001 – Richard D. Bucholz, M.D. The Fellows Award — recognizes a distinguished individual for outstanding achievement in science.

2015 – Samuel Achilefu, Ph.D. Enrico Di Cera, M.D. 2014 – David Holtzman, M.D. Daniela Salvemini, Ph.D. 2013 – Dale Dorsett, Ph.D. Samuel Klein, M.D. 2012 – Govindaswamy Chinnadurai, Ph.D. Scott L. Hultgren, Ph.D. 2011 – Duane Grandgenett, Ph.D. Toni Kutchan, Ph.D.

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The Innovation Award — recognizes a scientist or engineer age 40 or under who has demonstrated exceptional potential for future accomplishments in science, engineering or technology.

2015 – Gautam Dantas, Ph.D. Yiyu Shi, Ph.D. 2014 – Caitlin Kelleher, Ph.D. 2013 – Angel Baldan, Ph.D. Katherine Henzler-Wildman, Ph.D. 2012 – Audrey R. Odom, M.D., Ph.D. 2010 – Randall J. Bateman, M.D. Ganesh K. Venayagamoorthy, Ph.D. 2009 – Jonathan M. Chase, Ph.D. Timothy E. Holy, Ph.D. 2008 – Sonya Bahr, Ph.D. 2007 – Eric C. Leuthardt, M.D. Ali Shilatifard, Ph.D. 2005 – Shelley D. Minteer, Ph.D. 2004 – James H. Buckley, Ph.D. 2003 – Phyllis I. Hanson, M.D., Ph.D. James P. McCarter, M.D., Ph.D. 2002 – Karen L. Wooley, Ph.D. The Trustees Award — recognizes 2001 – Jonathan B. Losos, Ph.D. outstanding contributions in keeping 2000 – Steven F. Dowdy, Ph.D. with the Academy of Science mission Michael E. Wysession, Ph.D. of promoting the understanding and 1999 – Laura L. Dugan, M.D. appreciation of science. Through 1998 – Scott Hultgren, Ph.D. exceptional leadership and communication, 2000 – James M. Bornholdt, Ph.D. their impact crosses geographic boundaries 1996 – Alison Goate, Ph.D. and enriches private, public, and academic Robert D. Davinroy sectors.

1995 – Jacob D. Langer, M.D. 2015 – Jennifer K. Lodge, Ph.D. Robert Magill, Ph.D. The Science Educator Award — recognizes 2014 – Michael Cosmopoulos, Ph.D. a distinguished individual or organization George Yatskievych, Ph.D. on the basis of outstanding contributions 2013 – Pana Charumilind, Ph.D. to science education or to the public 2012 – Mabel L. Purkerson, M.D. understanding of science, engineering 2011 – Janey S. Symington, Ph.D. or technology.

Linda Cottler, Ph.D. 2014 – Robert J. Marquis, Ph.D. 2010 – Pfizer – St. Louis 2013 – James Wilson, Ph.D. Heidi R. Hope, Ph.D. 2012 – Michael W. Friedlander, Ph.D. 2009 – Lincoln I. Diuguid, Ph.D. Pamela Gay, Ph.D. 2008 – Paul Markovits, Ph.D. 2011 – Young Scientist Program, Paul A. Young, Ph.D. Washington University in St. Louis 2007 – Patricia E. Simmons, Ph.D. 2010 – Harold H. Harris, Ph.D. 2006 – Thomas A. Woolsey, M.D. 2009 – Victoria Lynn May 2005 – Charles R. Granger, Ph.D. 2008 – Harold R. Messler, B.S. 2004 – Luther S. Williams, Ph.D. John Ridgen, Ph.D. 2003 – Will D. Carpenter, Ph.D. 2007 – Patrick L. Osborne, Ph.D. 2002 – Jessie L. Ternberg, M.D., Ph.D. 2006 – Kenneth Mares, Ph.D. 2001 – Ernest G. Jaworski, Ph.D. 2005 – Robert A. Williams, Ph.D. 1999 – Willis V. Hauser 2004 – Paul H. Young, M.D. William L. McConnell

2010 – Alan L. Schwartz, Ph.D. 2009 – Cheryl S. Asa, Ph.D. Gerald Medoff, M.D. 2008 – Martin H. Israel, Ph.D. 2007 – Kattesh V. Katti, Ph.D. Robert M. Senior, M.D. 2006 – Barbara Schaal, Ph.D. Raymond E. Arvidson, Ph.D. 2005 – G. Alexander Patterson, M.D. Robert T. Fraley, Ph.D. 2004 – Patricia G. Parker, Ph.D. Clifford M. Will, Ph.D. 2003 – Susan Mackinnon, M.D. Raymond G. Slavin, M.D. 2002 – Carl M. Bender, Ph.D. Robert E. Ricklefs, Ph.D. 2001 – Christopher I. Byrnes, Ph.D. Dennis W. Choi, M.D., Ph.D. 2000 – Allen R. Atkins, Ph.D. Sarah C. R. Elgin, Ph.D. 1999 – Robert B. Belshe, M.D. Ananthachari Srinivasan, Ph.D.

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Fellows of the Academy Since its inception, the Academy has promoted the recognition of impressive scientists in the St. Louis area. This tradition continues with the Academy Fellows Induction and annual Outstanding St. Louis Scientists Awards. The Fellows of the Academy is a prestigious association of St. Louis scientists and engineers of national reputation. The Fellows organization creates opportunities to tap into the wealth of science and technology resources in our area for recommendations and insight. Many Fellows are recipients of an Outstanding St. Louis Scientist Award.

Samuel Achilefu, Ph.D.

Michael R. DeBaun, M.D., M.P.H.

Joseph J. H. Ackerman, Ph.D.

Kevin L. Deppermann

Ramesh K. Agarwal, Ph.D.

Enrico Di Cera, M.D.

Constantine E. Anagnostopoulos, Ph.D.

Dale Dorsett, Ph.D.

Charles L. Armstrong, Ph.D.

Milorad Dudukovic, Ph.D.

Raymond E. Arvidson, Ph.D.

Timothy J. Eberlein, M.D.

Cheryl S. Asa, Ph.D.

Sean R. Eddy, Ph.D.

Allen R. Atkins, Ph.D.

Sarah C. R. Elgin, Ph.D.

John P. Atkinson, M.D.

Alex S. Evers, M.D.

Bruce R. Bacon, M.D.

Claude M. Fauquet, Ph.D.

M. Carolyn Baum, Ph.D., O.T.R.

David A. Fischhoff, Ph.D.

Roger N. Beachy, Ph.D.

Henry (Hank) C. Foley, Ph.D.

Robert B. Belshe, M.D.

Robert T. Fraley, Ph.D.

Carl M. Bender, Ph.D.

Carl Frieden, Ph.D.

Stephen M. Beverley, Ph.D.

Richard H. Gelberman, M.D.

James A. Birchler, Ph.D.

George W. Gokel, Ph.D.

Pratim Biswas, Ph.D.

Ursula W. Goodenough, Ph.D.

Gregg Bogosian, Ph.D.

Jeffrey I. Gordon, M.D.

Sherri M. Brown, Ph.D.

George S. Graff

Richard D. Bucholz, M.D.

Duane Grandgenett, Ph.D.

Thomas P. Burris, Ph.D.

Charles R. Granger, Ph.D.

Will D. Carpenter, Ph.D.

Maurice Green, Ph.D.

James C. Carrington, Ph.D.

Gregory R. Heck, Ph.D.

William John Catalona, M.D.

S. Allen Heininger, D.Sc.

Bernard R. Chaitman, M.D.

John E. Heuser, M.D.

Babu Chalamala, Ph.D.

Charles M. Hohenberg, Ph.D.

Pana Charumilind, Ph.D.

David M. Holtzman, M.D.

Govindaswamy Chinnadurai, Ph.D.

Heidi R. Hope, Ph.D.

Dennis Choi, M.D., Ph.D.

Robert Horsch, Ph.D.

C. Robert Cloninger, M.D.

Scott J. Hultgren, Ph.D.

Graham A. Colditz, M.D., Ph.D.

Alberto Isidori, Ph.D.

Glenn C. Conroy, Ph.D.

Martin H. Israel, Ph.D.

Joel D. Cooper, M.D.

Ernest G. Jaworski, Ph.D.

C. Thomas Cori, Ph.D.

George B. Johnson, Jr., Ph.D.

Michael Cosmopoulos, Ph.D.

Kattesh V. Katti, M.Sc.Ed, Ph.D., D.Sc.

Linda Cottler, Ph.D.

Elizabeth A. (Toby) Kellogg, Ph.D.

Ramanath Cowsik, Ph.D.

Evan D. Kharasch, M.D., Ph.D.

Jerome R. Cox, Jr., D.Sc.

Charles Kilo, M.D., F.A.C.P., F.A.C.E.

Roy Curtiss, III, Ph.D.

Ganesh M. Kishore, Ph.D.

Ralph G. Dacey, Jr., M.D.

Samuel Klein, M.D.

William H. Danforth, M.D.

Stuart A. Kornfeld, M.D.

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Fellows of the Academy Don R. Kozlowski*

Sondra Schlesinger, Ph.D.

Toni Kutchan, Ph.D.

Robert D. Schreiber, Ph.D.

William M. Landau, M.D.

Irene T. Schulze, Ph.D.

James V. Leonard

Alan L. Schwartz, M.D., Ph.D.

Timothy J. Ley, M.D.

H. Gerard Schwartz, Jr., Ph.D., P.E., F.A.C.E.

Stephen H. Lipstein, MHA

Karen Seibert, Ph.D.

Jennifer K. Lodge, Ph.D.

Robert M. Senior, M.D.

Susan E. Mackinnon, M.D.

Larry J. Shapiro, M.D.

Robert Magill, Ph.D.

Sherman J. Silber, M.D., F.A.C.S.

Philip W. Majerus, M.D.

Patricia E. Simmons, Ph.D.

Elaine R. Mardis, Ph.D.

Jeffrey Skolnick, Ph.D.

Paul S. Markovits, Ph.D.

Eduardo Slatopolsky, M.D.

Garland R. Marshall, Ph.D.

Raymond G. Slavin, M.D.

Mildred Mattfeldt-Beman, Ph.D., R.D.

William S. Sly, M.D.

James M. McKelvey, Ph.D.

Donald L. Snyder, Ph.D.

Gerald Medoff, M.D.

Stuart A. Solin, Ph.D.

Brian J. Mitchell, Ph.D.

Lilianna Solnica-Krezel, Ph.D.

Rob Mitra, Ph.D.

Ananthachari Srinivasan, Ph.D.

Kelle H. Moley, M.D.

Philip D. Stahl, Ph.D.

John C. Morris, M.D.

Gary D. Stormo, Ph.D.

Aubrey R. Morrison, M.D., F.A.C.P., F.R.C.P.(C), F.R.C.P.(I)

Joan E. Strassmann, Ph.D.

Robert W. Murray, Ph.D.

Nobuo Suga, Ph.D.

Philip Needleman, Ph.D. Charles W. Oertli, P.E. Stephen R. Padgette, Ph.D. Yuanlong Pan, BVM, Ph.D. Patricia G. Parker, Ph.D. G. Alexander Patterson, M.D. William A. Peck, M.D. Carlos A. Perez, M.D. Frederick J. Perlak, Ph.D. David H. Perlmutter, M.D. Jane E. Phillips-Conroy, Ph.D. Richard E. Pinckert, Ph.D. Helen M. Piwnica-Worms, Ph.D. Kenneth S. Polonsky, M.D. Ettigounder Ponnusamy, Ph.D. Mabel L. Purkerson, M.D. Ralph S. Quatrano, Ph.D. Marcus E. Raichle, M.D. Peter H. Raven, Ph.D. Robert E. Ricklefs, Ph.D. Alexander Rubin, Ph.D. Yoram Rudy, Ph.D. J. Evan Sadler, M.D., Ph.D. Daniela Salvemini, Ph.D. Joshua R. Sanes, Ph.D. Krishnan K. Sankaran, Ph.D. Barbara A. Schaal, Ph.D. Milton J. Schlesinger. Ph.D.

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Claude N. Strauser, P.E., P.H., L.S. Janey S. Symington, Ph.D. Barna A Szabo, Ph.D. Steven L. Teitelbaum, M.D. Alan R. Templeton, Ph.D. Jessie L. Ternberg, M.D., Ph.D. Erik Trinkaus, Ph.D Jonathan S. Turner, Ph.D. Emil R. Unanue, M.D. David C. Van Essen, Ph.D. Richard L. Wahl, M.D. Lihong Wang, Ph.D. Robert H. Waterston, M.D., Ph.D. Patty Jo Watson, Ph.D. Virginia V. Weldon, M.D. Clifford M. Will, Ph.D. Luther S. Williams, Ph.D. Richard K. Wilson, Ph.D. Kevin A. Wise, Ph.D. William S. M. Wold, Ph.D. Thomas A. Woolsey, M.D. Mark S. Wrighton, Ph.D. Gregory Yablonsky, Ph.D. George Yatskievych, Ph.D. Frank C-P Yin, M.D., Ph.D. Wayne Yokoyama, M.D. Paul A. Young, Ph.D. Rudolph N. Yurkovich Charles F. Zorumski, M.D.

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Give the Joy of Science JOIN FELLOW BRILLIANT MINDS TO BUILD A BRIGHTER FUTURE FOR US ALL Membership in the Academy Members receive advance notice of programs led by today’s leading-edge scientists, invitations to members-only events, and a Junior Academy membership. Your generous gift today builds the doctors, engineers and physicists of tomorrow. A full 100% of your gift provides free programs for more than 80,000 students and adults annually.

James B. Eads Society Eads Society members are devoted to improving our quality of life through science with a generous gift of $500 or greater annually. Eads Society members receive private receptions with notable science speakers, special recognition in Report to the Community, and three Junior Academy memberships for friends, family, or students otherwise unable to join.

Charles P. Choteau Society Members of the Charles P. Choteau Society are committed to continuously connecting science and the community. Enjoy the feeling of giving a larger gift–but spread comfortably over the course of a year.

Dr. George Engelmann Society Engelmann Society members are devoted to building a brighter future by making a bequest to the Academy. Please consider The Academy of Science of St. Louis when making your estate plans. Your gift can be any size; you can specify a percentage or specific dollar armount in your will.

Or you can name the Academy as a beneficiary of your retirement plan or life insurance policy. Please consult your financial advisor or legal counsel to provide for the Academy.

Junior Academy Junior Academy membership includes members-only scientific field trips, advanced registration privileges, and Academy-sponsored science challenge contests. Memberships for students in grades 6 - 12 are $30 for one student or $40 for a family.

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2016 BOARD OF TRUSTEES AND STAFF Executive Committee Benjamin H. Hulsey, J.D. President Kenneth L. Wagner, J.D. Vice President Robert L. Caulk Treasurer J.J. Stupp Assistant Treasurer Jennifer K. Lodge, Ph.D. Secretary Philip O. Alderson, M.D. Of ficer Frank Doerner Of ficer Janet R. Jackson, Ph.D Of ficer Trustees & Ex-Officio Parviz H. Ansari, Ph.D. Jeffrey P. Bonner, Ph.D. James C. Carrington, Ph.D. Dedric A. Carter, Ph.D. Brian Clevinger, Ph.D. Graham Fisher, Ph.D. Dean L. Frank lin, J.D. Thomas George, Ph.D. Victoria Gonzalez Charles R. Granger, Ph.D. Charles Hoessle Rick Holton, Jr. Carissima Hudson, Ph.D. David Isserman Timothy Kessler Amy Komnick Frances Levine, Ph.D. Paul S. Markovits, Ph.D. Judy Medoff, Ph.D.

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Charles W. Oertli, P.E. James C. Peterson, Ph.D. Mabel Purkerson, M.D. Ralph S. Quatrano, Ph.D. Peter H. Raven, Ph.D. Barbara Schaal, Ph.D. William S. Sly, M.D. David A. Smoller, Ph.D. James A. Stemmler, J.D. Janey S. Symington, Ph.D. George Tomazi, P.E. Bert Vescolani Cheryl Watkins-Moore, D.P.M., M.B.A. David Carl Wilson, Ph.D. Greg Wilson, D.Sc. Peter Wyse Jackson, Ph.D. H. Gerard Schwartz, Jr., Ph.D., P.E., F.A.C.E. President Emeritus Thomas A. Woolsey, M.D. President Emeritus Staff Mary E. Burke Chief Executive Of ficer Denise Charles, CPA Chief Financial Of ficer Denise R. Baker Director of Development and Partnerships Pegg y James Nacke Director of Special Projects and Events Rose Jansen Director of Public Science Programs and Speakers for Science Natalie Eichelberger STEM Outreach Programs Associate Ashley Newport STEM Special Projects Coordinator

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To support the Academy’s mission as a donor, speaker, or volunteer please contact: The Academy of Science – St. Louis 5050 Oakland Avenue St. Louis, Missouri 63110 info@academyofsciencestl.org www.academyofsciencestl.org 314.533.8083

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