Comité técnico: PhD. Rosa del Carmen López-Sánchez, PhD. José A. Hernández-Hernández 3 2 ] [ 3 2 ]
FROM P ROM E T H E U S TO T H E P RE SENT DAY OX I DAT I V E ST RE SS: A W I ND OW O N TO T H E E N T RA I LS OF C OV I D-19 Dra. Ana Villaseñor-Todd PhD candidate (Technical committee: Rosa del Carmen LópezSánchez, PhD, and José A Hernández-Hernández, PhD) Mexican scientist noted for her research studies in minimal encephalopathy, oxidative stress, quality of life and social cognition. He complemented his graduate studies at Texas A&M University. Candidate to receive the degree of doctor of medicine by the UANL. Founder and CEO of AVE strategic consulting.
Having
stolen fire from the gods and given it to men , Prometheus received a hideous punishment: Z eus , the father of the gods , ordered that he be chained to a rock , and that an eagle should come every day to devour the hero’s liver, only for it to grow back overnight. Prometheus was condem ned to endless suffering.
In December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) broke out in Wuhan, China. The serious respiratory disease that this virus causes in human beings (COVID-19) has been declared a pandemic by the World Health Organization (Zhang and Ma, 2020). Several months ago, the Mexican government declared a public health emergency as a result of the SARS CoV-2 epidemic. My heart took a leap when I learned the news. The Ministry of External Affairs made a call to the scientific community to join in the work of research and analysis required to confront the pandemic. The situation is developing rapidly: as many as 20% of COVID-19 cases have been described as serious illnesses, with fever and pneumonia, leading to acute respiratory distress syndrome (ARDS) (Moore and June, 2020). There are no clear clinical or paraclinical parameters yet to
RESEARCH
indicate the course of its evolution. I have spent ten years of my life in the fascinating world of hepatocytes, oxidative stress, quality of life, and the effects of all these things on social cognition, as well as how metabolic comorbidities are associated with diseases of the severity of COVID-19. I have formulated a hypothesis here that I hope will interconnect all these matters. Chronic hepatitis is one of the leading causes of death all over the world. It can be caused by different mechanisms, including chronic viral infections, alcohol abuse, and metabolic alterations. It is known that, in the early stages, the liver can repair the damage caused to it, but that, if the ailment continues, the accumulation of molecules produces fibrosis, which eventually progresses towards cirrhosis and, finally, hepatocellular carcinoma (M. Masarone et al., 2018). The metabolic alterations that produce a significant accumulation of fat in more than 5% of hepatocytes and which are not the result of the consumption of a “dangerous” amount of alcohol or of any other cause of hepatic disorders constitute a potentially pathological condition known as nonalcoholic fatty liver disease (NAFLD).
