Our current issue deals with fundamental theoretical and applied aspects of the activation therapy. Everyone knows what is stress and how it affects the heart. It is also well known that H. Selye was the pioneer who described stress influences on complex of changes in the organism. However, we think of particular value is the contribution of L. Garkavi and her colleagues, first of all, E. Kvakina and M. Ukolova, to a better understanding of all the variety of the responses by an organism to external and internal stimuli.