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ItinhibitslipidTheKlothofamilyofproteinsconsistsofthreelesserextent,aKlothoisalsoexpressedinthepituitarymembers:aKlotho,eearegland,placenta, skeletalKlotho:AnantiagingproteininvolvedinmineralandvitaminDmetabolism.Clotho,oneoftheThreeFates,wasresponsibleforspinningthethreadof humanlifeSeeFullPDFDownloadPDFRelatedPapersKlothoesunaproteínatransmembranadeunsolopasoqueconstadeaminoácidosyseexpresafuerte ydébilmenteencélulasepitelialesrenalestubularesdistalesyproximalesDescensodelasíntesisrenaldeklotho:laanidaddeFGFporsureceptor(especialmente FGFR1anivelrenal)esmuybajaEncondicionessiológicas,elFGF23,alunirsealFGFR1,noseríacapazdegenerartransduccióndesenalAlagregarklotho,la anidaddelreceptoraumentasignicativamenteypermitelaactivacióndeFGFR1sobreelorganismoSeverallinesofevidencesupportthenotionthatKlotho functionsasahumanaging-suppressionmoleculeItinhibitslipidperoxidationandinflammation,aswellaspreventsendothelialinjuryandcalcificationofblood vesselsBackground:Klothoisananti-agingproteinwithseveraltherapeuticrolesinthepathophysiologyofdifferentorgans,suchastheskeletalmuscleand kidneysThestudiesthatappliedaerobicexerciseusedpercentagesofVO2maxorHRmax,41,tocontroltheintensityoftheprotocol.Journal, Klothoproteinis detectedmainlyinthekidneysandbrainTheincreaseinKlothoproteinrangedfromto%PolymorphismsofKLOTHOarecorrelatedwithlifespan,coronary arterydisease,atherosclerosisandosteoporosisinhumansKlothoprotectsagainstendothelialdysfunctionandregulatestheproductionofnitricoxideAsimismo, klotho(KL)esunaproteínaconefectoanti-edaddebido,probablemente,asupapelenelmetabolismodelfosfatoydelavitaminaDyenelcontroldelestrés oxidativoOutrafunçãovaliosadaproteínaklothoéseupapelnainterfacedosistemaneurológico,ajudandoaevitardoençasneurodegenerativasItisa coreceptorforfibroblastgrowthfactorandhenceisinvolvedinmaintainingendocrinesystemLogo,elafuncionacomoumanti-inflamatóriointracelulareumfator anti-envelhecimentonaturaldoserhumano.DominiquePrié.,KidneyInternational.AThediscoveryofklothohasagreatimpactonagingresearchKlothoprotein isassociatedwithagingandthenameofgenecomesfromGreekmythology[]Abstract Klothoproteinaffectsanumberofmetabolicpathwaysessentialfor pathogenesisofcardiovasculardiseasesandtheirpreventionAlgunosestudiosrelacionansuexpresiónconlafuerzamuscularyexistencoincidenciasenla respuestafisiológicadeKLylaactividadfísicaTheKlothoproteins,αKlothoandβKlotho,areessentialcomponentsofendocrinefibroblastgrowthfactor(FGF) receptorcomplexes,astheyarerequiredforthehigh-affinitybindingofFGF19Klotho(Klotho)isatransmembraneproteinthatwasinitiallythoughttobe expressedonlyinalimitednumberoftissues,mostimportantlythekidney,parathyroidglandandchoroidplexusKlothoisananti-agingproteinwithpleiotropic actionsthatexertsorganprotection[1,21]Umestudo,darevista, AbstractInrecentyears,thereisquitealotofinterestinKlothoproteinandsomediseases
Abstract Klothoproteinaffectsanumberofmetabolicpathwaysessentialforpathogenesisofcardiovasculardiseasesandtheirprevention.Klothoalsoinfluences intracellularsignalingpathwaysincludingp53/p21,cAMP,proteinkinaseC(PKC)andWntsignalingpathwaysAlémdisso,elaestáenvolvidanaproteçãodos órgãosinternos