Amsterdam Neuroscience - Self-Evaluation Report 2016-2021

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Consortia

Consortia help us to stay connected, broaden our network and showcase our research and expertise internationally, to show what we can do when we work together. Researchers from the Amsterdam Neuroscience research institute have been participating in or leading many consortia that include partners from all over the world and in various fields.

ABOARD: Stopping Alzheimer’s together before it starts ABOARD, in full ‘A personalized Medicine Approach for Alzheimer’s Disease’, is a large-scale research project carried out by a national, multidisciplinary consortium. This consortium of more than thirty partners works towards a future with personalized diagnoses, prediction and prevention of AD. Personalized medicine ABOARD’s mission is to make a start with personalized medicine for AD by making all the preparations for effective patient-directed diagnosis, prediction, and prevention. The goal is to pave the way for tailor-made treatment for Alzheimer’s so better strategies for diagnosing, predicting, and preventing Alzheimer’s can be created. In this way, patients and relatives feel supported and more in control. Collaborations The ABOARD consortium launched in April 2021. The project brings over thirty partners together, among which five Dutch Alzheimer centers, including the Alzheimer Center Amsterdam, a center of expertise of Amsterdam Appendix 6

Neuroscience, and patients’ organizations like Alzheimer Nederland. Public and private parties across the entire knowledge chain work together in this consortium, from universities to care and knowledge institutions, civil society organizations and businesses. An overview of all involved partners and more information about ABOARD can be found on the project website. Support by the Dutch government ABOARD is the first research project to be launched as part of the National Dementia Strategy 2021-2030 of the Ministry of Health, Welfare and Sport. It also contributes to the Knowledge and Innovation Agenda 2020-2023 of Health~Holland, in which public and private partners collaborate to improve the quality of life of people (Mission IV).

BRAINSCAPES: A roadmap from neurogenetics to neurobiology The Brainscapes consortium aims to map the biological mechanisms underlying multiple brain disorders. Recent genetic discovery studies have provided more insight into the genes involved in brain disorders. The next step is to use this knowledge for gaining mechanistic disease insight, although this is an extremely complex task to fulfill due to the involvement of many different research fields that all speak their own language. The research group that is coordinated by Professor Danielle Posthuma will develop novel analytic and experimental tools to study the functional consequences of risk genes on the function of specific cells, their circuits and functional output. These insights into the molecular and cellular basis of complex brain disorders can be used to design novel treatments. Long term funding On August 30, 2019, the Dutch Research Council (NWO) announced that the Brainscapes consortium was awarded a Gravitation grant to the value of €20 million. The Ministry of Education, Culture and Science provides

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