Eastman Institute of Oral Health Momentum 2014 volume 1 by University of Rochester Medical Center

2014 . Volume 1

For many patients, EIOH is a shelter in their storm story on page 4

Director’s Message

My first several months as Director of Eastman Institute for Oral Health at the University of Rochester Medical Center have given me an opportunity to learn and observe our strengths and weaknesses, and determine our short and long-term goals. Thanks to the level of dedication and the talented people I have met so far, I am confident in taking on these goals. Our commitment is to providing care and community service, teaching , and conducting top tier research. We need to gather and carefully allocate our resources to ensure the continued success of this mission. We are already progressing on several innovative ideas to better utilize space and finances. At a recent employee meeting, we discussed leadership styles and techniques – I maintain that this is a very complicated, yet important issue. I believe there are two types of leaders – some are born to lead, and there are those who learn to lead. Those who developed and honed their leadership skills over time are, in my opinion, the superior leaders. Effective leaders promote and nurture a shared common goal, allowing the organization to thrive through teamwork. A good leader must also make some tough decisions, while focusing on guiding teammates in reaching their highest potential to excel.

Editor’s note: So many of our patients endure deeply personal and incredibly difficult journeys. I am extremely grateful to Kathy, Theresa, Jill, Robert and Greg, who so generously shared their personal trials, and allowed me the privilege to write their stories. I am touched and honored to have done so, and am very proud to be a part of EIOH/ URMC, who not only was the shelter in their storm, but helped them gain renewed hope. Karen Black Editor, Momentum

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Photo composition by Keith Bullis

eioh | university of rochester medical center

Contents 2014 . Volume 1 4-15 Shelter in a Patient’s Storm 16 A Special Tribute 19 Center for Oral Biology Update

24 First Caton Fellow 26 News & Notes 30 Publications

Continuing to build our basic, clinical and translational research is a top priority. The kind of research we are doing throughout the Institute is relevant, influential and very exciting. I am looking forward to supporting research in the EIOH and establishing collaborations with various groups in the Medical Center and the University. Eastman Institute for Oral Health has earned its excellent reputation because of its unique international makeup, its commitment to exceptional training, firstrate clinical care and research. Throughout this issue, you will read about people from all different backgrounds who have endured cancer, or who have experienced debilitating pain. Because of the global expertise we bring to every patient and every procedure, they found relief at Eastman. I look forward to meeting more of you in the coming months, and working alongside you to maintain and exceed Eastman’s prominent international impact. I invite you to call or write anytime.

Eli Eliav, DMD, MSc, PhD Director & Professor Eastman Institute for Oral Health

Vice Dean for Oral Health School of Medicine and Dentistry University of Rochester Medical Center

Dr. Maricelle Abayon discussed urgent care services with Dr. Eliav shortly after he became director.

Eastman Institute for Oral Health 625 Elmwood Avenue, Box 683 Rochester, New York 14620-2989 www.urmc.rochester.edu/dentistry/

Editor Karen Black karen_black@urmc.rochester.edu Art Director Kathleen Mannix Photography Keith Bullis

Momentum is published by the University of Rochester Medical Center. momentum | 2014 . volume 1 3

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EIOH

Lucky Pays Off for this Patient

fter appointments with six different specialists hoping for relief from the increasing pain in her mouth, it was the seventh specialist who finally gave Kathy the help she longed for. “It was an ongoing, stabbing pain, and was worse when I ate foods with seasonings or spices,” explained Kathy (who prefers not to use her last name). “Certain textures, like the crust on a slice of bread, were too painful to eat.” Throughout her many visits to different specialists, she would either leave their office with a special rinse to provide temporary relief, or with an “I’m sorry, but I don’t know how to help you.” One specialist diagnosed her as having burning mouth sensation, and told her it affects about 1 in 500 people. Kathy, 65, used a rinse for about a year with some

success. “The rinse helped, but it never went away and started getting much worse a year later.” Along with the worsening burning sensation, other symptoms started to appear. “It looked like a big chunk on the left side of my tongue was gone, and there was white stuff on the inside of my cheeks,” Kathy described. “And the inside of my upper and bottom lips had the white stuff, plus red blisters.” It was at an appointment with a periodontist, Jack Caton, DDS, where Kathy found new hope. “Dr. Caton looked in my mouth and said, ‘I want you to go see this doctor who we hired for her knowledge about mouth diseases,’” she said. “He told me, ‘If anyone can help you, it’s going to be her.’ “At that point, I was struggling to eat scrambled eggs, cottage cheese and milk,” Kathy recalled. “Even drinking water hurt.”

eioh | university of rochester medical center

Sharon Elad, DMD – the seventh specialist Kathy saw – recently joined Eastman to chair its new Oral Medicine Division. Oral Medicine, which began gaining U.S. recognition in the 1940’s, focuses on the oral health care of medically complex patients and with the diagnosis and non– surgical management of medically-related disorders or conditions affecting the oral and maxillofacial region. For example, oral medicine specialists diagnose and treat conditions like oral ulcers, dry mouth, color changes of the oral lining, recurrent blisters, lumps or swelling, oral pain, burning mouth, taste disorders, oral infections, and benign growths, among others. “I was so impressed with her,” Kathy said. “She wouldn’t even look in my mouth until we went over my medicines.” At that time, Kathy, who became paralyzed from the waist down during a medical procedure

ince people have inhabited the earth, the number seven has held great significance historically, culturally and religiously.

7 colors of the rainbow • 7 Wonders of the ancient world 7 days of the week • the 7-day story of creation the 7 branches on a Menorah • 7 Chakras of meditation 7 heavens in Islamic traditions • THE 7 deadly sins • 7 planets 7 continents • 7 Periods in the Table of Elements 7 seas • the 7-year itch “Dr. Elad saved my life. I couldn’t stand the way I was living anymore. No one else seemed to know or care what I had, but she took the time.” —Kathy, a grateful patient

Kathy’s tongue before treatment (left) and following treatment from Dr. Sharon Elad (right). 16 years ago, was taking 28 different medications a day. “In addition to the white patches, Kathy’s oral presentation included redness (erythema) and ulcerations,” Elad explained. “The white patches were the result of two conditions occurring at the same time.” One of those conditions, Elad explained, involved removable white plaques that were diagnosed as oral candidiasis, or basically a yeast infection. The many medications she was taking induced dry mouth, which created favorable conditions for an oral fungal infection to emerge. Secondly, she had non-removable white color changes that were diagnosed as Lichen Planus/ lichenoid reaction, described as a chronic inflammatory reaction in the inner lining of the oral cavity. “For the naked eye, the mix of white patches, redness and ulcerations could easily look like missing chunks,” Elad continued.

“The chronic nature of this condition along with secondary infection and local trauma due to teeth imprints on the swollen soft tissue, probably enhanced the effects of the inflammation.” Elad recommended a biopsy in order to rule out a malignant transformation. “I was so impressed because Dr. Elad did the biopsy right in my wheelchair,” Kathy commented. “I’ve never seen anybody work on someone like that.” “During the first few appointments, the clinical presentation was severe with some tissue areas totally losing the normal shape,” Elad described. “LP/lichenoid is defined as a potentially malignant disorder, so it was important to rule out malignant transformation. The lab report came back negative for cancer or dysplasia and conclusive for LP/lichenoid.” The next step was to determine why this painful condition was happening to Kathy.

Elad read carefully through her medical background and the medications list. “I compared the list with literature resources about medications that are associated with lichenoid reaction,” she said. “Once these medications are identified, attempts are made, in consultation with the physician who prescribed it, to find a substitute.” But that can be easier said than done, especially if the suspected medications are key for balance of a fragile medical condition, or if many medications are suspected as the culprit, determining which one to replace can be very challenging. “Furthermore, since lichenoid reaction is associated with numerous medications and materials, it is difficult to prove a definitive link to a suspected drug or material as a similar reaction may develop with the second line of treatment, too,” Elad reiterated.

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Dr. Elad, Oral Medicine chair, diagnoses and treats conditions like oral ulcers, dry mouth, color changes of the oral lining, recurrent blisters, lumps or swelling, oral pain, burning mouth, taste disorders, oral infections, and benign growths, among others. After careful and thorough analysis and collaboration with her other providers, five of Kathy’s medications were stopped, and her treatment was adjusted accordingly. “Dr. Elad saved my life,” Kathy said. “I couldn’t stand the way I was living anymore. No one else seemed to know or care what I had, but she took the time. She’s very personable and truly cares.” During three weeks between appointments doing a rinse four times a day, Kathy was back to eating almost all normal foods again. “I’ll never forget the first time I sat down and had a cheeseburger,” she remembered. “I was so thankful.” Today, Kathy continues to see Elad, as part of her routine follow up. “Her current condition is much better than when I first saw her,” Elad said. “As with any chronic condition, there are ups and downs, but we adjust treatment as needed, and we work together to give her the best possible care.” “Because this is chronic, I recognize that there’s still a road ahead of me,” added Kathy, “but I’m so glad there is a Dr. Elad to help me along the way.”

eioh | university of rochester medical center

Q. Oral Medicine is relatively

new in this area – do you find it challenging to explain what this specialty is and how it can benefit patients?

A. Absolutely. In many regions in

the world oral medicine is a wellrecognized specialty, with long training programs, and high-impact in academic institutes. The U.S. is different, as oral medicine accredited training programs only started recently and oral medicine is largely only found in academic health centers. So it is a challenge to explain how valuable oral medicine can be for patients, the dental professionals, the university and the medical community.

Sharon Elad, DMD, MSc

Q. When did you know and why did you choose Oral Medicine?

A. Since I was an undergraduate

student I was working as a research assistant in the Department of Bone Marrow Transplantation. My BSc and DMD theses were about certain medical complications in patients undergoing bone marrow transplantation. During graduate studies, I found the topic of medically complex patients intriguing. After graduation,

Getting to Know Dr. Sharon Elad gaining experience in hospital dentistry was attractive to me. The protean exposure I had during the four-year oral medicine program had a great impact on my professional career. During this entire time I continued developing a special interaction with the departments of Bone Marrow Transplantation, Hematology and Oncology in respect to clinical service, research and education.

A. Yes! There is room for many

more collaborations. Oral medicine interfaces with dermatology, internal medicine, solid-organ transplantation, ophthalmology, rheumatology, OB/GYN and many more medical specialties.

Q. What types of research are you involved in?

A. Currently I’m involved in

multiple research projects. Here are a few examples: part of being in Oral Medicine? • Developing a novel treatment for oral chronic graft versus host A. Having the opportunity to disease contribute unique knowledge to • Developing the Multinational patient care, often in cases in which Association of Supportive Care in the patient suffered from a chronic Cancer / International Society of oral disease for a long time. Likewise, Oral Oncology (MASCC/ISOO) the familiarity with both dentistry guidelines for managing oral and medicine allows me to introduce mucositis concepts arising in medicine into the • Assessing the effect of oral chronic dentistry world and vice versa. graft versus host disease on saliva secretion, taste and quality of life Q. Right now you work out of • Reviewing bleeding risk in SMH and Wilmot Cancer Center patients treated with novel Do you envision partnerships with anticoagulants other areas within URMC?

Q. What is the most rewarding

Q. Describe some of your other

professional affiliations/activities?

A. Co-chair of the Mucositis

Study Group of the Multinational Association of Supportive Care in Cancer / International Society of Oral Oncology (MASCC/ISOO) • Organize the annual research workshop, moderate panels, write position papers • Chair section within the Oral Care Study Group Member of the American Academy of Oral Medicine • Immediate Past Secretary of the International Society of Oral Oncology • Author of many book chapters, publications in professional journals • Invited speaker, oral medicine advisor to groups around the world

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Dentistry Partners with URMC to Help Patients t started one day last summer, when

room, where they discovered a tumor.

60-year-old Jill Terhune had suddenly

A tracheotomy was performed for a

lost her voice and the urgent care center

biopsy, and a few weeks later, the

sent her home with antibiotics. Her voice

cancerous tumor, along with her larynx,

never came back fully and stayed raspy

also known as the voice box, were

in the following months. On Christmas

removed.

Eve, she had difficulty breathing and went back to urgent care, where they diagnosed her with viral bronchitis and gave her an inhaler. Still suffering a week later, she went to the emergency

Terhune is just one of countless people who suddenly find themselves facing a serious illness and subsequent treatments that could involve strong medications, radiation and/or chemotherapy. A dental evaluation before treatment can provide many benefits, like reducing the risk and severity of complications, such as jaw bone damage. For Terhune, she had 11 teeth extracted prior to radiation.

Patient Jill Terhune

8 eioh | university of rochester medical center

“We have provided pre-treatment dental care for Strong Memorial Hospital’s specialty care patients for nearly 20 years,” said Lisa Sansone, RDH, coordinator for Specialty Care in EIOH’s Oral Medicine Division. Specialty care includes those who have cancer or an infectious disease, those undergoing a transplant or other surgeries, or receiving radiation or chemotherapy. “Clearing oral infections prior to cancer treatment often includes treating cavities, fractured teeth, gum disease, or multiple extractions, performed by an EIOH General Practice Residency resident or an Oral and Maxillofacial surgeon.” Now, thanks to a newly formed group of dedicated URMC professionals across several disciplines, a new system is in place to help patients get proper long term dental care after treatment, a longstanding gap that EIOH Social Worker Lenora Colaruotolo was determined to close. Dental treatment before a transplant, surgery or radiation is deemed medically necessary and is covered by medical insurance or the hospital’s Charity Care program. When their hospital procedures are completed, patients are then referred to Eastman Dental for follow-up long-term dental care. But, Colaruotolo explains, as an Article 28 institution, Eastman Dental does not have a Charity Care program or a hardship fund for meeting the needs of those patients who are uninsured or underinsured. “Patients without adequate dental insurance who may need dentures, partial dentures or restorations are those we are not able to serve, unless they have financial means to pay for dental treatment. “For many, this leaves very limited options for affordable, follow-up dental care,” she continued. “It was difficult to witness situations where so many patients

(l to right) Cindy Micelli, Robert Ulp, Dr. Nirmala Tasgaonkar

just completing cancer treatment were forced to manage with few or no teeth. The stress of a cancer diagnosis and treatment is hard enough, yet now they’re also dealing with quality-of-life, dignity, and functionality challenges that can negatively impact their recovery.” “Because of the long term effects of radiation and chemotherapy on the oral cavity, ongoing dental care after cancer treatment is extremely important for recovery,” added Sansone, who has been working with specialty care patients for many years.

A First Step in Closing the Gap “Lenora put together a diverse group of professionals who were all in some way connected to the problem and wished to make a difference and find a solution,” explained Nirmala Tasgaonkar, DDS, assistant professor in EIOH’s Community Dentistry Division. “These included a head and neck nurse, social workers, a hygienist, dentists, administrators and coordinators from EIOH, Wilmot Cancer Center, Head & Neck, Bone Marrow Transplant and Infectious Disease.” After initial brainstorming meetings, the new task force collaborated with Sharon Elad, DMD, MSc, chair, EIOH Oral Medicine Division, to help develop an organized referral system partnering with Jo Ann Snyder, RN, BSN, Head and Neck Surgery nurse coordinator at the Wilmot Cancer Center. Head and Neck patients who did not have his or her own dentist would be referred to Eastman Dental’s clinic at School #17. “What began as an informal referral process soon became a regular stream of patients coming to our clinic for treatment and follow up,” Tasgaonkar said. After

genetically bad teeth, and explained that her brittle teeth led to several cavities and root canals and procedures that didn’t go well. “One dentist didn’t believe me when I told him the Novocain wasn’t working and another yelled at Snyder sends a me to stop crying when the gas comprehensive he used hadn’t taken update on the effect yet.” patient and their As a part-time employee medical history, for a food vending machine Tasgaonkar’s team company, she does not have ensures the patient dental insurance; plus her visit is comfortable, fear and anxiety prevented anxiety-free and her from going for preventive pleasant. “We visits. To ease her nerves, she provide an exam, brought son Corey Terhune diagnosis, explain a along to her first visit at treatment plan and EIOH Social Worker Eastman Dental. Lenora Colaruotolo schedule subsequent “Turns out, I had nothing visits.” to be afraid of,” Jill Terhune said. “Dr. T “We use a multidisciplinary team is so laid back and easy going and funny! approach to coordinate care of our patients,” She made me laugh, which made me much explained Snyder. “While there was a strong more comfortable. She and Cindy are such a pathway to pre-treatment care, we were caring team.” lacking a good post treatment pathway to After Dr. Tasgaonker examined Terhune, care for these special needs patients. Dr. she provided a cleaning and treated a few Tasgaonker has stepped in and become cavities to prepare for her new upper and an active member of the team. She is lower partial dentures. accessible and knowledgeable about patients’ Proudly showing off those new dentures, disease and treatment consequences, Jill said she is very grateful for the care she and she develops timely and appropriate received. “I feel like a new person.” individualized treatment plans.” Another patient referred by Wilmot After one radiation treatment, Terhune, Cancer Center is Robert Ulp, a Vietnam a single mother of two grown boys, was veteran and a former patent illustrator. unable to complete the process due to Diagnosed with Agent Orange related Nonextreme claustrophobia and anxiety. Because Hodgkin’s Lymphoma in 1989, he was treatment stopped, she was ready for follow- treated with aggressive radiation treatment up dental care, but her life-long fear of in his upper chest, neck and lower jaw, dentists triggered more anxiety. which arrested the disease but severely “I had my first filling when I was 3 years damaged the function of his salivary glands. old,” explained Terhune, who says she has This, in turn, accelerated damage to his

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Rochester's School 17, one of Eastman Dental's community locations.

dentition, leading to frequent repair of small areas of decay and occasional removal of teeth too damaged to repair. A relapse of the disease in 1996 was successfully treated with chemotherapy which further impaired recovery of his struggling salivary function. “By 2010, the Non-Hodgkin’s had morphed into an aggressive bone marrow cancer,” Ulp explained. “What followed was 96 straight hours of chemotherapy, which arrested the disease.” He then went through six months of intermittent chemotherapy, which he said caused further damage to his salivary glands, resulting in additional tooth decay and more extracted teeth. “I had chronic dry mouth, which not only damaged the ability of normal salivary action in my mouth to protect my teeth, but made even a simple phone conversation difficult to sustain,” Ulp remembered. As his dentist expressed increased concern over this condition and the specter of substantially higher costs arose, he asked his oncologist if he could provide a referral for treatmentrelated dental work. He was referred to Tasgaonkar, who soon initiated a program of repair and extraction procedures preparing for upper and lower dentures. “I found Dr. T and the staff at Eastman Dental to be very easy-going and competent in their professions, providing a friendly and relaxed atmosphere as work progressed,” Ulp said. “My new dentures are now fitted and comfortable. They are truly a well-made example of the craftsman’s art and I feel

Task Force Members Lenora Colaruotolo, LMSW, Sr. Social Worker, Eastman Institute for Oral Health Mike Ellis, LMSW, Social Worker, Blood & Marrow Transplant Jo Ann Snyder, RN, BSN, Head and Neck Surgery Nurse Coordinator, Wilmot Cancer Center Rita Goodman, LMSW, Social Worker, Wilmot Cancer Center Sandra Sabatka, LMSW, Sr. Social Worker, Wilmot Cancer Center Frank Cannizzaro, LMSW, Social Worker, Infectious Disease Lisa Sansone, RDH, BS, Coordinator for Specialty Care Patients, Oral Medicine, Eastman Institute for Oral Health Patricia Carlson, DDS, Assistant Professor, General Practice Residency, Eastman Institute for Oral Health Sharon Elad, DMD, MSc, Chair, Oral Medicine, Eastman Institute for Oral Health Nirmala Tasgaonkar, BDS, MDS, MS, MBA, assistant professor, EIOH Community Dentistry Carol Vanini, MS, Director of EIOH Advancement Thanks also to Gina Curtiss, former School 17 Practice Manager, Cindy Miceli, Dental Assistant, Amber McGowan, Coordinator

fortunate to have made the connection to Dr. T and her staff at Eastman Dental for this restoration work.” To date, more than 30 patients have benefited from the efforts of this task force, with high patient satisfaction. But, Colaruotolo says, there are still many who need help. Often, dental insurance coverage doesn’t pay for everything, and many

eioh | university of rochester medical center

patients suffer financial hardship as they and their caregiver have had to stop work during treatment and recovery. “Having good teeth or comfortable dentures are important to function for getting good nutrition, as well as appearance,” added Snyder. “It not only helps their physical well being, but also their self esteem and mental health.” “We are looking at every option in search of supplemental funding, including benefit events, outreach, and grant opportunities,” Colaruotolo said. “Specialty care patients need our help the most as maintaining adequate nutrition and weight gain is a priority for return to optimal health.” “This new referral system is a positive step to ensure post-treatment dental care and will prove very beneficial for many patients,” Sansone added. Other EIOH clinics are part of the organized referral system, and include General Dentistry, Prosthodontics, Eastman Dental Downtown and the University Dental Faculty Group at Clinton Crossings. “Faculty and staff from these clinics collaborate as a multi-disciplinary team dedicated to the important goal of providing excellent oral health care to our specialty care patients,” said Elad. “Among the leads are Drs. Yunker and Ercoli who are very committed to the goal.” Colaruotolo hopes to eventually influence legislation that will ensure comprehensive health insurance coverage for oral health care, yet in the meantime, she and the task force are working to increase awareness, partner with organizations such as the Seventh District Dental Society of New York, American Dental Association, and the American Cancer Society, as well as continue to seek funding sources.

Dentist using a Kodak Dental Camera at the Rochester Dental Dispensary in the 1920s.

From the time we opened our doors, Eastman has been known for innovative approaches to education, research, and caring for our community. We would not be where we are today without the annual support of our alumni and friends. Annual Giving Programs

University of Rochester

800.598.1330

annualfunds@rochester.edu

You are an important part of Eastman’s history. Be part of our future evolution by making a gift today. Visit Rochester.edu/giving/innovation. momentum | 2014 . volume 1 11

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Theresa Nelson is pain-free, thanks to Dr. Liu (right)

ome people believe in coincidence, while others believe that a certain chain of events is orchestrated by the hand of a higher being. Whatever the source, Theresa Nelson of Elmira, NY, is incredibly happy that her particular series of events led her to Eastman Dental, where she finally received relief from pain she had been experiencing for years. Many years ago, Nelson had a bridge placed involving the back three right upper teeth. More recently, her dentist told her she had a small cavity on the tongue side of that last tooth at the gum line. He filled it, but it fell out— twice. The third time he used a different material, and explained it was challenging because of the cavity’s location. What followed was continuous pain in the same area, and several visits back to the dentist, to no avail. After checking the need for a possible root canal, she said her dentist fixed a couple malocclusions, but insisted nothing else was wrong. “The pain increased in intensity,” Nelson remembered, “I would frequently have to stop eating because the pain was so severe and radiated across every tooth on the right. Also, I had been chewing mostly on my left side because the right side was so sensitive. I reached the point where I felt I just wanted the whole bridge removed.” Then a new situation occurred. Nelson’s jaw began to go out of joint and then get stuck. Yawning, laughing or eating an ice cream cone would trigger it, but she figured out how to push it back in place when it happened. “In addition to the tooth pain, I was now having a lot of pain and headaches associated with my jaw,” she explained.

EIOH Resident Eliminates Patient’s Prolonged Pain “I searched online and found the TMJ Clinic at Eastman Dental.” TMJ expert Ross Tallents, DDS, examined her and agreed that clearly something was going on with the tooth in back, and would not treat the TMJD until the tooth issue was resolved. At that point, Nelson sought the advice of another dentist, who filed down part of the ridge, and provided minimal relief. To add insult to injury, Nelson was diagnosed with chronic fatigue syndrome. “It seemed as though every system in my body was turned upside down…I was having multiple symptoms, on top of terrible head, jaw and neck pain,” she said. “The pain would come out of nowhere and intensify greatly,” she explained. “I was at a dinner to celebrate my daughter’s college graduation, but the pain was so incredible I had to stop eating. It was then and there that I decided to call Eastman Dental. “When I called for the appointment, the person I spoke with said she would do all she could to get me in quickly,” Nelson said. “She ended up getting me in that Saturday…I was thrilled!”

eioh | university of rochester medical center

And it was that Saturday morning, whether by coincidence or fate, she met Xiuxin Liu, DDS, PhD, a resident at that time in Eastman’s Advanced Education in General Dentistry program who has a special interest in the diagnosis and management of dental orofacial pain. He recently completed research about ATP signaling, which provides energy for living cells in dental orofacial pain, and its implication in dentin hypersensitivity. That study, which proposed to explain why different stimuli induce similar pain in the teeth, was published in the Journal of Dental Research. Because of his novel approach in this area, Liu recently landed a coveted twoyear National Institutes of Health clinical translation science institute grant – the KL2 Scholar Award – to continue his work in this area of dental orofacial pain. After listening to Nelson’s story and performing a thorough exam, Liu explained that he thought the filling was jagged, irritating the gum and causing pain. “He talked about understanding pain and that I had dealt with the pain for so long that my nerves likely became hypersensitized,” Nelson remembered. “Dr. Liu gently cleaned up the affected teeth, took x-rays and had me schedule another visit with him to give him time to check

Getting to Know Dr. Liu the x-rays and review my case with his supervisor. “When I came back for the second visit, the pain was the same in intensity,” she said. “Based on the x-rays and my response to the tests from the first visit, Dr. Liu was certain the filling was the cause of my agonizing tooth pain.” “Pain is not just a harmful sensation, but pain itself can induce inflammation and injury to the tissues.” Liu explained. “For Mrs. Nelson’s case, palliative care and avoidance of secondary injury are necessary for tuning down her sensitized nerves. Stress relief and nutritional instruction would also be helpful for her comprehensive rehabilitation.” After cleaning and reshaping it, Liu removed a significant amount of filling material. At the end of the following day, Nelson noted that she had not experienced awful pain at all that day, or the next and the next. “At my third visit with Dr. Liu, I was so excited to report that the intense, incredible pain was gone!” Nelson said. “I explained to him, however, that while I could chew soft foods on my right side, I still had an issue with chewing harder foods. Dr. Liu felt it could be an occlusal issue and made an adjustment. “I am happy to report that I now can chew all foods on my right side, something I hadn’t been able to do for quite a long time. “I feel so grateful to Dr. Liu for diagnosing the source of my severe tooth pain,” she explained. “While it is a two hour drive for me to get to Eastman Dental, I feel it is well worth it to have Dr. Liu address the health of my teeth.”

s a clinician-scientist with a background in neuroscience, Liu’s research activity at Eastman has focused on the underlying mechanism of pain sensitization, a situation that usually occurs with chronic pain patients who show extreme pain to a light or even non-harmful stimulus. With a strong interest in clinical translational research, Liu’s research activities have encompassed multiple fields since he graduated from dental school in China. “Solving clinical problems is the long-term objective for my research,” Liu said. Liu earned his PhD in Pharmacology at Heidelberg University in Germany and then worked in electrophysiology. Before becoming an AEGD resident at Eastman, Liu worked as a postdoctoral fellow and faculty in Neurobiology at Yale University. “I chose Eastman because of its reputation and its roots in research and invention,” Liu added. “Many significant advancements in dentistry have come from Eastman dentists, like Drs. Bibby and Buonocore, whose work changed the profile of dentistry in the past century. Liu’s ideal job would be to have a lab with sufficient resources and facilities to carry out clinical translational research. “This would enable me to not only provide service in clinics, but also to make contributions for the development of new techniques in pursuing better diagnoses and therapies. “I am fortunate that I get support from Drs. Malmström, Ren and Eliav for my research at Eastman,” he added. “It has been the very right choice for me to select this institution.”

A self-described risk taker, Liu says the biggest risk in his life was 10 years ago, when he decided to come to the U.S. “It was a cold, windy afternoon when my son and I landed at Kennedy International Airport,” he recalled. “For the first two weeks, we slept on the floor of an apartment in New Haven, CT, and in those moments, I had no idea what my family’s life would be like in this new world.” It hasn’t been such a bad ride so far. His wife, Qin Amy Wang, DDS, PhD, graduated from the AEGD program in 2012, and now practices dentistry in Virginia. His son Max Liu, is a graduate of UCLA and is now a second year MD, PhD student at the University of Iowa Carver College of Medicine, and is planning a career in neurology.

I chose Eastman because of its reputation and its roots in research and invention. – Xiuxin Liu, DDS, PhD

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Makeover Winner

Smiles a Lot More Now

Greg Ras, center, celebrates his new smile with (l to r) his father Michael Ras, Dr. Elyce Link, Dr. Carlo Ercoli and his mother Colleen Ras.

wenty-five year old Gregory Ras says he is treated differently now than he used to be. Acquaintances and co-workers seem to be friendlier and more outgoing toward him. He thinks it’s because of his new teeth. But Gregory’s mom, Colleen Ras, thinks his overall confidence and self esteem have grown considerably since his smile makeover, and as a result, people respond more favorably than before. “Hundreds of people like Greg who entered our Smile Makeover contest were unhappy with their teeth and shared similar sentiments – they were too embarrassed and self-conscious to smile or go out in public; or they had lost teeth and always cover their mouth with their hand,” remembers Carlo Ercoli, DDS, chair, Prosthodontics Division at Eastman Dental. “We completely understand that one’s teeth can impact quality of life, either positively or negatively. That’s why choosing just a few winners from nearly 1,000 people who entered our smile makeover contest was a very difficult challenge.”

Gregory had been diagnosed with two congenital conditions where some of his teeth were missing (oligodontia), and the ones he did have were smaller than normal size (microdontia). Ercoli said they are both common, people can get either one or the other or both, and with varying degrees of severity. “It can range from affecting one tooth, which can be missing or misshaped, to many teeth as in Greg’s case,” Ercoli explained. “The more teeth affected, the more complex the case gets as the gum and bone structure do not form as well as they should.” “We had been to a few specialists to get estimates on how to fix his teeth, but without insurance covering most of the work, it was extremely expensive,” explained Colleen. “So when I saw the ad for the contest, I definitely encouraged him to enter.” “I wanted to get a better smile to look nice, so I entered the contest,” Greg said. “We were all so surprised and ecstatic

eioh | university of rochester medical center

when he won!” said Colleen. The specialists in Eastman Dental’s Prosthodontics, Periodontics and Orthodontics divisions collaborated to develop Greg’s treatment plan. He would need a full arch implant-supported bridge in the lower arch and implant-supported crowns and tooth bridges in the upper arch. “His upper premolars were extracted and four implants were placed,” explained Ercoli, who oversaw Greg’s case over the two years and four months of treatment. “After the implants were placed, Gregory spent about six months in orthodontic treatment.” Orthodontics resident Evan Brown, DDS, who was supervised by attending faculty Edward Sommers, DDS, provided treatment to move his upper left canine and create more space for his upper left bridge. Next, all of his lower malformed baby teeth were extracted, except for his permanent molars and six implants were placed. After the orthodontic treatment was completed and the healing period for the implant was finished, the final

I’m loving my new smile. — Gregory Ras

prostheses were delivered. In the upper arch, four implant crowns replaced the missing premolars and two three-unity bridges supported on his central incisors and canines replacing the missing upper lateral incisors. In the lower arch, long span implant bridge supported by six implants replaced all his missing teeth except for his molars. “It’s been exceptional care,” Colleen said. “So professional, smart and caring through every step of the process. They’ve been wonderful and patient, really thorough and great bedside manner…we couldn’t have asked for any better. Dr. Ercoli was attentive and a pleasure to meet and go through this

experience with. We are so lucky to get all this care from him and all his residents. “Gregory’s smile looks fantastic, more grown up, and just a perfect fit for him!” she added. “I believe his overall confidence about his looks will help to continue to keep growing as a person at work and in his personal life. I can tell he feels good about it.” “I’m loving my new smile,” Gregory said, smiling. “Originally, I thought they would grind my teeth down, but they did a lot more work than I thought..the whole process was a learning experience for me. They definitely exceeded my expectations.” Greg added that they were very considerate,

trying to match him with doctors that fit his personality, accommodating his work schedule, and always making sure he was comfortable. “I definitely smile more than I used to,” Greg said. “My friends and co-workers say my teeth look awesome. My family, aunts and uncles have also complimented me and say I now have the best teeth in my family!” In addition to Dr. Carlo Ercoli, the residents who were involved in treating Greg include Drs. Berge Wazirian, Kostas Chochlidakis, Dimitri Papadimitriou, and Elyce Link.

It’s been exceptional care, so professional, smart and caring through every step of the process. – Colleen Ras

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nnn EIOH News

A Special Tribute and a Lasting Legacy

Dr. Baig’s late parents, (l to r) Mohammed K. Baig and Najma Begum

rowing up in India, Mohammed “Bobby” Baig’s father served as a strong role model for him. The senior M.K. Baig’s number one passion was helping others. Professionally, as Minister of Education in the state of Andhra Pradesh, India, he worked tirelessly to change policy and was instrumental in bringing advanced technical education there. He convinced the state government to build reservoirs and install pipelines to help residents on the top of a mountain have clean drinking water pumped up the mountain. For years, women would descend 1,000 steps to the base and then carry water all the way back to the top. “In 1992, when there were major riots in India due to the demolition of the Babri Mosque, the only place in the whole country without a single untoward incident was my city Vijayawada,” Bobby recalled. “My father worked tirelessly with the community and the peace-keeping forces to maintain normalcy.” Recognizing his father’s contributions to

eioh | university of rochester medical center

the society, the government of India gave him a National Award for Peace in 1994; to date, a number of high schools, education centers and markets have been named after him. Outside of his professional life, he and Bobby’s mother, Najma Begum, worked together to advocate and support causes related to education, health care and children with their time, talent and treasure. “My dad was very smart and hardworking, but also very compassionate and generous,” described Bobby (Prostho ’11). Bobby’s parents were incredibly supportive of his goal to be a dentist and prosthodontist; and in 2007, when his mom was diagnosed with cancer, his parents tried to keep the situation as worry-free as possible for him, wanting him to focus on his studies. “It was a very stressful time,” Bobby recalled when he was at Eastman as a resident. “I didn’t want to let my family down. I was trying to help from here, while

trying to focus and give everything to my work in the prosthodontics program. My co-residents Zandi, Mario, Eduardo, Tamer, Berge, Andre and Boza and the faculty were incredibly supportive the entire time, like my family away from home.” His mother fought hard, but in 2011, the cancer was progressing and she was very ill. “I wanted nothing more than to have my parents in the audience during the graduation ceremony,” Bobby said, “but my mom was undergoing cancer treatment and they understandably couldn’t come.” Six months later in December of 2011, an unexpected turn of events occurred. His father had a heart attack at age 71 and passed away. And then eight months later, his mother lost her battle with cancer at age 61.

Their deaths left a deep void to all who knew and loved them and who were touched by their work. Bobby and his brother and sisters have been working to carry on their parents’ legacy, by donating food, clothing and books to those in need, and helping support free medical, dental and vision care to charity programs under “Baig & Najma Charitable Trust.” “We have gone to several schools to provide much-needed books and supplies for the kids,” Bobby added. “My parents helped so many people, we are happy to continue their work and know it would make their souls happy. “Every time I talk about my mom, I feel like 100 angels are on me,” he said with a huge smile. “I’m blessed to have such a wonderful family.”

After graduation, Bobby went back to work with Izchak Barzilay, DDS (Prostho ’86, MS ’91) in Toronto, where he served as an Education Center Coordinator. Barzilay has long been his mentor and the one who originally recommended that he apply to Eastman for the Prosthodontics program. Bobby also teaches one day at Toronto University and drives to Rochester to teach two days a week at Eastman Dental. One day, Prosthodontics Chair and Program Director Carlo Ercoli, DDS (Prostho ’96, TMJ ’97, Gen Den ’99, Perio ’12) called Bobby to tell him about a major fundraiser for the department, and asked him how he could help. “When I heard about the plans and design, I was very impressed,” Bobby said. “And then he asked me, ‘what do you think you can do?’

One of the new prostho treatment rooms ready for patients

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Dr. Baig (Prostho ’11) is excited about the Prosthodontics program’s future. “When I was in the program, I always And then another unexpected turn of heard my senior colleagues talk about the events occurred. need to settle down before giving back Ercoli told Bobby his donation qualifies something in return for the education they as a naming gift, and said he wanted to received,” Bobby said. “I understood where name the Cone Beam CT Room after they were coming from, but didn’t agree his parents. completely. “He told me, “Bobby, you know I’ve “The very day I finished my program at never met your parents, but I’ve known you Eastman, I felt so comfortable; I learned for so many years as a part of this program, so much in my program, I thought I can and I can tell what good people they are and always give back. I can plan myself in such that you were brought up very well.’ a way I should be able to give as early as “I was so surprised—I had no idea that possible,” he said matter-of-factly. would be part of my gift,” Bobby said. So Ercoli set up Baig’s gift of $10,000 “We are all going to come and leave this over five years. earth, but my parents’ names are going to “Some people may think five years is stay as long as this building is here. Having short term, but if you’re practicing every them recognized in this way is so touching day, five years is a long time,” he said. “If I because of their passion for education and can’t give $10,000 back to the department how much they supported me while I was in five years, then something is wrong here. My whole family is thrilled.” with my training. After getting trained by world class faculty at Eastman I had all the confidence to say ‘Yes.’”

Family is very special to Baig, who considers Eastman an extension of his own family. “Eastman is an amazing institute,” he said. “I think we are way ahead of programs in other universities in the U.S. and Canada. Getting my education under the guidance of Drs. Graser, Ercoli, Tallents, Soltys, Bafile and Oster, I could not have asked for more. “Apart from being teachers with worldclass knowledge, they are also the most humble people you’ll ever meet,” Bobby added. “Eastman not only taught me Prosthodontics, but how humble you can be as a human being. I think about the ways Dr. Barzilay has given back to this building. He and my father are two great men with major influence in my life. If I do even a fraction of what they’ve done, it will be the greatest achievement in my life.” Bobby recently was offered a package to increase his hours at Toronto University, matching his compensation at Eastman, and reminding him he could eliminate all the drive time back and forth to Rochester. “I told them, ‘it’s not about the driving, it’s a special bond with this place,” Bobby said. “Thank you for your offer, but Eastman comes first.’’

"Getting my education under the guidance of Drs. Graser, Ercoli, Tallents, Soltys, Bafile and Oster, I could not have asked for more." – Mohammed "Bobby" Baig, BDS (Prostho ’11)

eioh | university of rochester medical center

EIOH News

Center for Oral Biology Update Saliva, essential for oral health, is critical for maintaining oral homeostasis and serves multiple functions, including lubrication, digestion, protection of oral and dental tissues, and host defense. However, a variety of conditions can cause major disruptions in function, including normal aging and drug interactions, as well as systemic diseases, such as diabetes. The most common disease involving the salivary glands is Sjögren’s syndrome, an autoimmune disease affecting up to 4 million Americans, mostly middle-aged women. Furthermore, an estimated 52,000 people each year are diagnosed with head and neck cancers and are treated with radiation. This therapy often results in permanent damage to the salivary glands due to irreversible loss of the secretory acinar cells. The long-term outcome is a significant decrease in salivary flow, known as xerostomia. Short interfering RNAs (siRNAs), small molecules that can be introduced into the salivary gland cells, to block the process of cell death from being activated by the radiation treatment. (photo by Marit Aure)

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nn Dr. Catherine Ovitt discusses the research findings with AEGD resident and postdoctoral fellow Szilvia Arany, DMD, PhD. “Currently available treatments are temporary and do not result in repair of the glands. The availability of stem or progenitor cells would open the way for cellbased regenerative approaches,” explained Catherine Ovitt, Ph.D., Center for Oral Biology scientist and associate professor in the department of Biomedical Genetics. To address these issues, Ovitt and her team have three projects underway involving both molecular and cellular approaches to protect or restore salivary gland function.

Protecting the Salivary Gland From Radiation Damage One project involves treating the salivary gland in mice before radiation exposure, in an attempt to block cell death, which is the process that is initiated by radiation. The resulting loss of sensitive secretory cells leads to a decline in salivary gland function. Supported by National Institutes for Dental and Craniofacial Research, this project showed initial success and was published recently in Molecular Therapy. Ovitt and her colleagues used short interfering RNAs (siRNAs), small molecules that can be introduced into the salivary gland cells, to block the process of cell death from being activated by the radiation treatment. “Two issues were paramount for success,” Ovitt explained. “One was efficient delivery into the cells and the second was to specifically block the cell death process.” In order to carry the siRNAs into the salivary gland cells, they coupled the siRNAs to nanoparticles developed in the laboratory of Danielle Benoit, Ph.D., assistant professor in Biomedical Engineering. The siRNAnanoparticle complexes were retroductally injected into the mouse salivary gland excretory ducts by Szilvia Arany, Ph.D. The mice were then treated with radiation. They soon determined that the siRNAs hit their mark, greatly reducing the amount of cell death that took place after radiation treatment. Not only did the siRNAs protect

eioh | university of rochester medical center

EIOH News

Dr. Ovitt is surrounded by members of her laboratory. Pei-Lun Weng, Marit Aure, Szilvia Arany, Andrew Shubin, Catherine Ovitt, Seo-Kyoung Hwang, Eri Maruyama. Seated (l to r) Mridula Vinjamuri and Mireya Gonzalez-Begne. (not pictured – Michael Rogers)

the cells from radiation damage, but they also preserved their secretory function. After three months, the treated mice had 50 percent more salivary flow than irradiated mice that were not pre-treated with siRNAs. “Our results suggest that this approach could be an effective means of protecting salivary glands during radiation treatment of head and neck cancer patients,” Ovitt said. She also pointed out that the approach has significant advantages over alternative methods. First, the treatment can be limited to the salivary glands, so it should not affect genes in other tissues. Second, in contrast to many gene therapy strategies, this technique does not involve the use of viruses. And finally, siRNAs are very short-lived, producing only temporary changes in gene expression. Investigations of the method are continuing, to order to determine whether the siRNA-nanoparticle complexes are effective with fractionated radiation treatments, such as are administered to human patients.

Progenitor Cell Populations in the Adult Salivary Gland Another project in Ovitt’s lab is to identify and characterize stem or progenitor cells in the salivary glands, with the goal of harnessing those cells for repairing damaged or diseased glands.

Maintenance of the salivary glands requires continued generation of new cells over time, but the source of these cells is unknown. “Understanding how the salivary glands are normally maintained to replace aging cells in the glands of adults is essential in order to design cell-based repair therapies,” Ovitt said. “Using mouse models in which we can study regeneration, we have focused on the role of two potential cell populations in the adult salivary gland.” They are currently testing the ability of these individual cell types to contribute to regeneration of a gland damaged by radiation.

Regenerating Salivary Glands After Irradiation The third area of focus is the application of bioengineered materials, such as hydrogels, in strategies developed for the regeneration of salivary glands damaged by radiation treatments for head and neck cancers. “Several critical obstacles must be resolved before cell-based therapy for dysfunctional salivary glands can be moved into the clinical arena,” Ovitt said. “These include the identification of appropriate donor cells, the technology for promoting implantation into the gland, and direct functional assays to assess the outcomes.”

Members of Ovitt’s lab are using the powerful and well-defined genetic tools available in mice for tracing cell lineages, and defining important cell types. In collaboration with Benoit’s lab, they are testing the use of tunable hydrogel scaffolds for the introduction of those cells into damaged irradiated glands. “The hydrogels can be synthetically modified to include environmental and cellular cues required for cell differentiation in vitro and in vivo,” she added. “The goal is to determine if the use of hydrogels can protect transplanted progenitor cells and promote regeneration of damaged salivary glands.” The most often cited approach for treating salivary gland dysfunction caused by radiation therapy is the transplantation of stem cells, but many critical questions still need to be addressed, including what cells would work best, how to protect the cells once they are transplanted, and whether they can actually regenerate a functional gland. “Although it is clear that experiments in mice are a long way from treating patients with xerostomia, our work with mice helps us to address these important questions,” Ovitt added. “Only by resolving these critical issues, can we progress toward repairing damaged salivary glands in patients who have undergone radiation therapy.”

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nnn Alumni Profile

Joel Brodsky, DDS, MS (Ortho ’76, MS ’81) Momentum recently caught up with Joel

Brodsky, who recently vacationed in China and stopped by to say hello to fellow alum Walter Li (Ortho ’79, MS ‘80). Since he graduated from the Ortho program in 1976, Joel Brodsky has been in private practice in Lakewood, California, where his son Charles joined him in 2005. Brodsky says he has had the pleasure of treating as many as three generations of area families, and the relationships he’s developed has been by far the most rewarding part of his job.

Q. Why did you choose Eastman for your residency?

A. While at UCLA I was mentored by

Dr. Lawrence Furstman, who was one of the first trained orthodontists in Beverly Hills. He had graduated from Illinois under Dr. Brodie a number of years before Dr. Subtelny. He told me I should go to Rochester as they had the best program! I was very fortunate to have Dr. Subtelny accept me. I decided to get my master’s degree from the U of R. I had kept procrastinating writing my thesis. In late 1979, Dr. Johanssen, chair of the Dental Research Department, told me that I had until June 1980 to finish my thesis or forget it. With the help of Dr. Subtelny and Dr. Gilda, I defended my thesis in May 1980 and finally received my master’s.

Q. What are you doing now? A. I am working full time in my private

practice with my son Charles and still loving the field. I feel orthodontics is THE greatest profession in the world! I lecture on 3D imaging as we have had an ICat in the office for six years. We provide 3D services for specialists and general dentists, and we boast one of the largest patient databases of Dicom data. Our data has been used by university programs and we were lucky to host EDC graduate Dr. Jenny Haskell who

used our data for her published research project. I taught at UCLA for eight years and did research there as well. My son and I devote time to several cleft palate teams in Southern California.

Q. What are some of your favorite memories of the program and Rochester? A. Dr. Gilda's kindness and his wax bone

carving and anatomy classes. Dr. Subtelny's Hot Seat (really!) and time in the clinic, which really set the stage for developing our thought processes. Dr. Gugino's clinic days teaching us the "Rickett's" philosophy of treatment. Dr. Carl Musgrave's bread and butter techniques that I still use today. And finally, the Cleft Palate staffing days when we prepared x-rays, photos and models on our cleft palate patients and then went over progress and treatment plans for them. Cleft palate and surgical cases are a large part of our practice today...probably a great legacy and tribute to Dr. Subtelny. Favorite memories of Rochester include Don and Bob's hamburgers and ice cream, trips to the apple cider mill, sailing on Lake Ontario with Dr. Robert Rosenblum and of course the fall colors.

Q. Tell me about your visit

with Dr. Li – were you friends at Eastman? A. Dr. Li was actually two years behind

me so our clinical training never overlapped. However, I met him when he interviewed and we instantly hit it off. He visited after graduation and I promised that he would be the first person I saw when I visited Hong Kong. Fast forward 35 years…I contacted Dr. Li and told him I was finally coming. What we found was an instant camaraderie and an amazingly warm, kind, giving, and engaging individual. He introduced us to that part of the world and showed us Hong Kong and the pride and love he has for it.

eioh | university of rochester medical center

Dr. Joel Brodsky with Dr. Walter Li and his wife Edie at the Luk Yu Tea House in Hong Kong.

Q. When you see other friends

from Eastman – do you always reminisce, or is that chapter closed? A. I was very fortunate to make some

long lasting friendships at Eastman. Dr. Bruce Haskell is one of my closest friends. He and his wife Joy lived across the hall from us at the old apartment building at the EDC on Main Street. We have celebrated life’s milestones together and look forward to participating in the same Angle chapter and the AAO. Dr. Bob Bray was my big brother and we enjoy a close bond. He and his wife lived in the apartment below us. Dr. Marshall Deeney was my little brother and I remember him with great fondness as does everyone at Eastman. What a terrible loss. Dr. Cyril Meyerowitz lived downstairs as well and was doing his GPR. We were friends and I was convinced he was headed for greatness. And yes, we still reminisce...

EIOH News

Welcome New Board Members

Bruce Tandy, DMD Bruce Tandy first learned about Eastman Dental when he observed patient treatment as a biology major at the UR in the early 1970’s, and in 1978 when he applied to the GPR program. Fast forward to Meliora weekend a few years ago, when he took an Eastman Dental tour. “Bill Calnon, who I knew from the ADA, explained the future goals and strategies to me and I thought it sounded interesting and in line with some of my organized dental pursuits,” Tandy said. “The combination of grad education, research, and community health will be important to the future of the profession as a whole and EIOH may help lead the way.” Tandy is no stranger to community

service. He has served on the American Dental Association’s Communications Council, Smile Health Advisory and Strategic Planning committees. Tandy has also been very active with the Connecticut State Dental Association, YMCA and

the Vernon Jaycees. Closest to his heart, perhaps, is helping the underserved. For the past seven years, Tandy has been working with the local and national branches of Mission of Mercy. “I love working and coordinating the huge group of people necessary to run these projects,” Tandy said. “But walking the line before the project opens and meeting the people who are seeking care is the highlight for me. This is the purist form of treatment I provide as a dentist – no business to run, just taking care of people in need.” When not taking care of patients, Tandy, a self-described tech geek, plays golf, enjoys food and wine, and travels as much as possible. “But enjoying time with my wife and family makes all the work worthwhile.”

Bruce Tandy, DMD

Michael David Grassi, DDS, MDS “It was an honor to be nominated and selected to be on the Foundation Board,” said Grassi, who has been involved with the UR for more than 20 years, first lecturing in the late 80’s and then as Section Head of Endodontics at UR School of Medicine and Dentistry since 1990. “The EDC Board has been active and involved with our community and I look forward to participating,” said Grassi, a Rochester, N.Y. native and active community servant, both within and outside the dental profession. “Serving on the Board will allow me the vehicle to continue to reach out, not only to my professional peers, but also to all people in the surrounding com-

munity. I look forward to assisting Eastman in its decision making for the next several years.” A teacher at heart, Grassi taught swimming and diving lessons in high school and college, and also became a teacher’s assistant. “I enjoy watching others learn and develop as individuals,” said Grassi , who believes it’s the responsibility of professionals to encourage and inspire others through example and mentoring. “Teaching serves to open minds of all ages to the place where their abilities, knowledge and outlook encompass a greater ability to serve.” “My parents, my siblings, and my own personal family have grown up with the acknowledgement that we do not live in a vacuum and need to return some of

Michael David Grassi, DDS, MDS ourselves to society,” Grassi added. In his free time, he enjoys reading, exercising and relaxing, but is usually spending time with his three sons and supporting their activities.

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nnn Resident Profile

Dr. Fan Named First Caton Fellow Alumni Friendships and Support (l to r) Drs. Vivian S. Morad (Perio ’93), Jack Caton (Perio ’73, MS ’73), Mary Ann Lester (Perio ’94), Vivienne Allain (Gen Den ’90, Perio ’93), Jingyuan Fan, and Vivien Kwok (Perio ’05)

Jingyuan Fan, DDS, PhD with her mentor Jack Caton, DDS, MS (Perio ’73, MS ’73)

er passion for research, treating patients and teaching is just one of the many reasons Jingyuan Fan, DDS, PhD was recently named the first Jack G. Caton Fellow. “Dr. Fan is the best resident in our clinical program in both didactics and clinical performance,” said Jack Caton, DDS, MS, professor and chair, Eastman Institute for Oral Health’s Periodontics Division. “She is relentless in her clinical efficiency, tireless in didactic studies and is marvelous with patients, faculty, staff and her fellow residents.” The Fellowship was established in 2008 to further Dr. Caton’s vision of academic excellence by providing a grant to one or more individuals committed to scholarly and clinical advancement in Periodontology. The recipient will be interested in pursuing an academic or administrative position related to the Periodontics specialty, and have experience in clinical, academic, administrative, and/or clinical research work in Periodontics. “One of the important missions of Eastman Institute for Oral Health is to train

the future leaders of dentistry,” said EIOH Director Eli Eliav, DDS, PhD. “This is the type of the award that is very effective in stimulating careers and to encourage people to consider full time academics.” “This Fellowship provides another opportunity to foster expert educators, promote career development within the field of dentistry and support educational innovation and research,” Caton said. “Fellows will work closely with other faculty and staff to implement educational projects, learn educational theories, explore new teaching methods, and develop skills in educational research and curriculum innovation.” A native of Wuhan, China, Fan’s love for translational science and teaching has grown more with each year since dental school, where she became very interested in biomedical science, specifically microbiology and immunology, and pursued a doctorate degree in oral biology. She studied under the widely known Mark Herzberg, DDS, PhD, at the University of Minnesota, and gained more exposure to different types of research, including oral bacteria’s link to cardiovascular disease, and oral-biofilm formation. Fan studied the link between oral bacterial-induced platelet aggregation and infective endocarditis. “Our lab in Minnesota found that a protein has a role in the pathogenesis of infective endocarditis,”

eioh | university of rochester medical center

noted Fan, “and can be a potential target for preventing and treating this type of heart disease.” After finishing her PhD program in four years, she applied to Eastman Institute’s Periodontics program. “Having published so many research articles, Dr. Caton is very well known, and I was nervous about interviewing. The program has such a good reputation and is known for being one of the most challenging,” said Fan, who felt very fortunate to have been accepted. After teaching Chinese to international students in dental school, she found it fulfilling to help people to understand and

learn new things. She also served as a coinstructor for a couple classes to graduate students in Minnesota and really enjoyed it. “At Eastman, I have learned a lot from our faculty and senior residents,” she added. “My own personal experience as a student and periodontal resident has helped me understand the vital importance of mentorship.” Fan credits Caton as being the best teacher and mentor she’s ever had. “He always encourages our critical thinking and creativity,” she said. “He provides us with freedom to pursue our goals and work independently. Dr. Caton teaches us not just periodontics from textbooks and literatures, but also how to deal with some complicated real life situations. He is always happy to share his experiences with a sense of humor. We all love his contagious laughter.” Carlo Ercoli, DDS, chair of EIOH Prosthodontics program and graduate of the Periodontics program, agrees with Fan. “He did a lot for all of us. Not only does Dr. Caton provide the very best training, but he always supports graduates with their future endeavors. He is held in very high regard by alumni and colleagues around the world.” Ercoli (Perio ’12), along with Paul Romano, DDS (Perio ’97) and

Jack G. Caton, Jr., DDS, MS, has received numerous awards and honors for his contributions to Periodontology during his 40-year career. He has served his profession as commissioner for the Commission on Dental Accreditation, and as director and chairman of the American Board of Periodontology. He is past president of the AAP and also served as secretary-treasurer and president of the AAP Foundation Board of Directors. His honors include The William J. Gies Award in Periodontology, the Gold Medal for contribution to the specialty of Periodontics from the American Academy of Periodontology, the 2008 Bryan Frantz, DDS (Perio ’87) are leading the effort in providing this lasting tribute to him through the Caton Fellowship. “Dr. Caton is truly a very special teacher, mentor and friend,” Frantz said. “Many of us have been influenced by him in our resident training, or through our involvement in dental organizations. His commitment to the field of periodontology and the international recognition and prestige he has achieved through his teaching style at Eastman Dental shall forever be a part of the academic, research and teaching environment.” “One of the best things about Eastman is its great faculty,” said Remi Arseneau, DMD, (Perio ’12), who, after finishing the program, started his own practice in New Brunswick, Canada. “The Eastman program challenges its residents to become the top of their field. Such programs deserve our support and I am proud to contribute to the success of its best and brightest.”

Norton Ross Award winner for contribution to clinical research in dentistry, recognizing his 100+ published scientific articles and chapters on periodontal wound healing, animal models, diagnosis, and human clinical trials. Caton began teaching at Eastman following graduation and became program director in 1990. He earned his DDS from the Univ. of California, San Francisco and a U.S. Army certificate in Advanced General Dentistry. He also earned a master’s in Dental Science from the University of Rochester. He is also in private practice with fellow alumni Drs. Paul Romano and Timothy Blieden.

Fan definitely qualifies as one of Eastman’s best and brightest. She has authored several research articles and a book chapter, earned several awards including the prestigious American Academy of Periodontology Foundation’s Educator Scholarship, The W.H. Bowen Award from the American Association for Dental Research, a Block Grant Fellowship at the University of Minnesota-Twin Cities and two Outstanding Student Awards from the Chongqing Medical University. “Dr. Fan has made a great sacrifice to extend her education to prepare for a career in academics,” Caton continued. “She will be an outstanding role model because of her strong research background and outstanding clinical abilities.” For more information about supporting the Jack G. Caton Fellowship, please contact Dr. Ercoli at Carlo_ercoli@urmc. rochester.edu or Carol Vanini at Carol. Vanini@rochester.edu.

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nnn News & Notes

Update: National Dental Practice Based Research Network To date, the Northeast region, run by EIOH and one of the six administrative nodes of the National Dental Practice-Based Research Network, has recruited 824 of the 4,630 members nationwide. Funded by a $67 million NIDCR grant awarded to the lead institution, the University of Alabama at Birmingham, the network is a consortium of practices and clinics devoted principally to conducting practice based research to improve the oral health care of patients, with members investigating research questions with practical impact that will improve the quality of dental care. Nationally, there are numerous studies in the pipeline in various stages of development. One study originating from the Northeast region is on dentine hypersensitivity, and has been approved by the network’s executive committee and NIDCR. The primary objective of the study, led by principal investigator and EIOH associate professor Dorota Kopycka-Kedzierawski,

DDS, MPH, is to characterize methods of diagnosing dentin hypersensitivity in the practice setting and dentists’ selected treatment(s), and their respective effectiveness. Some 180 practitioners and 2,500 adult patients will be recruited from all six National Dental PBRN regions. You can play an important role The secondary objectives are to evaluate in improving dental care across the nation!

patient-, practitioner-, practice- and toothlevel characteristics that may contribute to practitioners’ decisions towards their approach to care and to assess patients’ satisfaction with the received treatment. Two Practitioner Advisory Committees have been established in the Northeast region. The Practitioner Core Advisory Group provides input into study development and comments on studies during their development. They assist with recruiting participants for the network and also for studies. Members also advise and assist with disseminating study The National Dental PBRN is a non-profit research network. Its major source of funding is from the National Institute of Dental and Craniofacial Research (NIDCR), which is part of the National Institutes of Health (NIH). OUR MISSION:

To improve oral health by conducting dental practice- based research and by serving dental professionals with education and collegiality

results, engaging and recognizing network participants, and help foster interaction with colleagues in other network regions. The Annual Meeting Advisory Committee advises the Northeast Administrative hub on the design and location of the annual meeting including associated logistics. “In addition to the annual meeting to be held early next year, we are also the host site for the ‘Face to Face’ meeting of the network next September,” added Cyril Meyerowitz, DDS, MS, EIOH professor and director of the Northeast region. “That meeting brings together the entire networks’ administrative staff, central administration, Westat, the coordinating center, and NIDCR representatives.” Interested in joining the network? Visit nationaldentalpbrn.org to learn more or enroll. If you have questions about the Northeast region, don’t hesitate to contact Kathy Bohn at 585-273-5272 or Kathy_ Bohn@urmc.rochester.edu

The National Dental Practice-Based Research Network (National Dental PBRN) is comprised of practitioners who are committed to advancing oral health knowledge by participating in research.

The Northeast Region encompasses Connecticut, Delaware, District of Columbia, Maine, Maryland, Massachusetts, New Hampshire, New Jersey, New York, Pennsylvania, Puerto Rico, Rhode Island, US Virgin Islands, and Vermont. Staff at Regional Centers across the nation will be your connection to the network. Central administration of the network is provided by the University of Alabama at Birmingham under the direction of Gregg Gilbert, DDS, MBA, FAAHD, FICD.

Visit the National Dental Practice Based Research Network website for more information: www.nationaldentalpbrn.org

Jacqueline Abranches, PhD has been

promoted to assistant professor of Microbiology & Immunology in the Center for Oral Biology. Abranches was educated in her native Brazil at the Federal University of Rio de Janeiro, obtaining her PhD in Environmental Microbiology.

She came to Rochester in 2000 to work in the Dept. of Microbiology & Immunology and later relocated to the University of Florida. She was recruited back to Rochester in 2007 as a research assistant professor. Her research interests concern the virulence characteristics of the oral streptococci, with an emphasis on species able to colonize damaged heart valves. Abranches has won a number of awards during her training and is nationally and internationally known for her work. Her current work is funded by the National Institute for Dental and Craniofacial Research of the NIH. WHAT ARE THE BENEFITS OF JOINING?

Aliakbar Bahreman, DDS, MS (Ortho’ 67)

HOW DO I BECOME A MEMBER?

Conduct research in your practice

Expand your knowledge base for making clinical decisions Enhance the image of your practice

Engage staff in the excitement of discovery and quality improvement Achieve continuing education credits

Receive financial remuneration for the time spent doing studies

Enroll in the network by completing the enrollment questionnaire at: www.nationaldentalpbrn.org

Participation in the network is at one of three levels: Informational-receive newsletters and correspondence Limited-receive newsletters, correspondence, and participate in surveys Full-receive newsletters, correspondence, participate in surveys,

Meet and interact with other practitioners involved in the network Participate in the dissemination of study results

Contribute to the development of knowledge that improves oral health

eioh | university of rochester medical center

Aliakbar Bahreman

has been named an Honorary Fellow by the International College of Dentists for his ethical, positive, continuous contributions to the profession.

News & Notes

Center for Oral Biology’s William H. Bowen, PhD, DSc, a

world-renown authority on causes and prevention of tooth decay, celebrated his 80th birthday with his wife Carole (left) and (l to r) Robert Quivey, PhD, Kurt Schilling, PhD, and James Melvin, DDS. Edward Chappelle, DDS

(Gen Den ’81), (right) president of the National Dental Association, accepted the invitation of Harold Kolodney, DMD

(Gen Den ’81), president of the Mississippi Dental Association, to be a guest at their annual session.

AEGD December graduates are (l to r) Drs. Di Le, Xiuxin Liu and Hector Rodriguez

Jocelyn Abi-Nahed, DDS

(Ortho ’11) welcomed daughter Chanel Nicole Soo Chan

Drs. Linda Rasubala (left) and Ximena Velasquez

COB colleagues threw a surprise party for Barb Sperduto, who’s retiring from her job as secretary after 14 years. (l to r) Wendy Keck, Jan Murphy, Barb Sperduto, Nici Beaumont, and Doris Wheeler

demonstrated brushing techniques to students at the Children’s School at URMC, as part of an oral health educational presentation. They were joined by several other GPR and AEGD residents.

momentum | 2014 . volume 1 27

nnn News & Notes

Congratulations to Center for Oral Biology’s Takamitsu Maruyama, PhD, and Ming Jiang, PhD, with Biomedical Genetics, for winning the The American Society for Bone and Mineral Research 2013 Raisz-Drezner Award. The award recognizes the first authors of meritorious scientific publication published in the Journal of Bone and Mineral Research. It is named for Lawrence G. Raisz,

MD, founder of the journal and Marc K. Drezner, MD, who expanded its international reach and helped maintain its high ranking. The award includes a $1,000 honorarium and a plaque. The award-winning paper is “Gpr177, a novel locus for bonemineral-density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development.”

ASBMR co-chair Dr. Laurie McCauley presents Dr. Maruyama the award.

Takamitsu Maruyama, PhD, was also recognized for his abstract, covering new data but an extension of the JBMR paper. He was selected to receive this year’s Young Investigator Award at the American Society for Bone and Mineral Research meeting, where he delivered a Distinguished Oral Presentation.

Catherine Ovitt, PhD, Center for Oral

Jiang Fu, MD, PhD, received a travel award

Biology scientist, and associate professor in the department of Biomedical Genetics, was selected to participate in the 2013 Mid-Career Women Faculty Professional Development Seminar, designed for women physicians and scientists holding medical school appointments at the associate professor level, and holding leadership positions within their discipline, department or institution. Seminar participants are chosen from various schools in the U.S. and Canada for their demonstrated leadership abilities and offer knowledge, inspiration and valuable career advice to participants.

from the American Society for Cell Biology to present his work on epidermal stem cells at its annual meeting. Fu’s research focuses on the regulation of stem cells essential for organ development, repair and regeneration. He is particularly interested in gene regulatory networks underlying development of the tissue-specific stem cells in health and disease.

Kolman Apt, DMD, (Ortho ‘85) was

inducted into the American College of Dentists

Robert Berkowitz, DDS, professor

and chair, EIOH Pediatric Dentistry Division, was invited to present his lecture, Clinical Outcomes for Severe Early Childhood Caries, at an early childhood caries symposium held at the Collegium Stomatologicum, Jagiellonian University in Krakow Poland, one of the oldest universities in the world.

Wei Hsu, PhD, professor of Biomedical Genetics and Oncology (left) with Jiang Fu

Leopoldo Vesco, DDS (Ortho

‘13) has been appointed a parttime teacher in the orthodontic program of San Carlos State University, Guatemala. Leo Vesco

In Sympathy The Eastman Institute for Oral Health expresses sympathy to the loved ones of our deceased alumni and friends

eioh | university of rochester medical center

Susan Cort McHugh (wife of former Eastman Dental Director Dr. William McHugh) passed away December 5, 2013.

Dr. Myron H. Nozik (Gen Den ’64) passed away September 28, 2013.

News & Notes William R. Calnon, DDS

(GPR ’79) was given the Director’s Award, for his extraordinary service, philanthropy and leadership to the Eastman Institute for Oral Health, and the University of Rochester, as well as his dedication and commitment that inspire others to serve. Many friends, family and colleagues joined the celebration at the George Eastman House.

Dr. Eliav (left) presented the prestigious award to Dr. Calnon

(l to r) Mrs. Harriette Howitt, Dr. Jack Howitt, Mrs. Jacqueline Lipschitz, Dr. Wayne Lipschitz, Ms. Alysa Plummer, Dr. J. Daniel Subtelny

(l to r) Dr. Sean McLaren, Mrs. Andrea McLaren, Ms. Katia Azevedo, Mrs. Kathryn Malmstrom, Mrs. Jane Levy

(l to r) Ms. Diane Caselli, Mr. John Caselli

momentum | summer 2013 29

nnn EIOH Publications

Recent EIOH Publications Malmström HS, Xiao J, Romanos G, Ren YF (2013) Two-year success rate of implantretained mandibular overdentures by novice general dentistry residents, Journal of Oral Implantology Leja C, Germiniani A, Caton J. Romanos GE, (2013), Thermodynamic effects of laser irradiation of implants placed in bone: an in vitro study, Lasers Med Sci Zadik Y, Zeevi I, Luboshitz-Shon N, DAkwar N, Wolff A Shapira MY, Or R, Elad S (2013). Safety and efficacy of an intro-oral electrostimulator for the relief of dry mouth in patients with chronic graversus host disease: Case Series., Med Oral Patol Oral Cir Bucal Aviles-Reyes A, Miller JH, Sipson-Haidaris PJ, Lemos JA, Abranches J., Cnm is a mjor virulence factor of invastive Streptococcus mutans and part of a conserved three-gene locus (2012), Mol Oral Microbiol Elad S, Zadik Y, Yarom N, Or R, Shapira M, Hematopoietic stem cells and bisphosphonate-related osteoncrosis of the jaw (2013), Oral Dis Elad, S., Zadik, Y., Yarom, N., Or, R., & Shapira, M. (2013). Hematopoietic stem cells and bisphosphonate-related osteonecrosis of the jaw. Oral Disease Gaca, A. O., Kajfasz, J. K., Miller, J. H., Liu, K., Wang, J. D., Abranches, J., & Lemos, J. A. (2013). Basal levels of (p) ppGpp in enterococcus faecalis: The magic beyond the stringent response. Mbio

Koo, H., Falsetta, M. L., & Klein, M. I. (2013). The exopolysaccharide matrix: A virulence determinant of cariogenic biofilm. Journal of Dental Research Kopycka-Kedzierawski, D. T., & Billings, R. J. (2013). Comparative effectiveness study to assess two examination modalities used to detect dental caries in preschool urban children. Telemedicine Journal and e-Health: The Official Journal of the American Telemedicine Association Romanos, G. E., Gladkova, N. D., Feldchtein, F. I., Karabut, M. M., Kiseleva, E. B., Snopova, L. B., & Fomina, Y. V. (2013). Oral mucosa response to laser patterned microcoagulation (LPM) treatment. an animal study. Lasers in Medical Science Santiago, B., Marek, M., Faustoferri, R. C., & Quivey, R. G., Jr. (2013). The streptococcus mutans aminotransferase encoded by ilvE is regulated by CodY and CcpA. Journal of Bacteriology Abranches, J., Tijerina, P., Aviles-Reyes, A., Gaca, A. O., Kajfasz, J. K., & Lemos, J. A. (2013). The cell wall-targeting antibiotic stimulon of enterococcus faecalis. PloS One Arany, S., Benoit, D. S., Dewhurst, S., & Ovitt, C. E. (2013). Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo. Molecular Therapy: The Journal of the American Society of Gene Therapy Bowen, W. H. (2013). Pointing the way to better oral health. Journal of the American Dental Association

eioh | university of rochester medical center

Bowen, W. H. (2013). Rodent model in caries research. Odontology / the Society of the Nippon Dental University Bowen, W. H. (2013). The stephan curve revisited. Odontology / the Society of the Nippon Dental University Elad, S., Bowen, J., Zadik, Y., Lalla, R. V., & Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). (2013). Development of the MASCC/ISOO clinical practice guidelines for mucositis: Considerations underlying the process. Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer Feng, G., Klein, M. I., Gregoire, S., Singh, A. P., Vorsa, N., & Koo, H. (2013). The specific degree-of-polymerization of A-type proanthocyanidin oligomers impacts streptococcus mutans glucan-mediated adhesion and transcriptome responses within biofilms. Biofouling Lemos, J. A., Quivey, R. G., Jr., Koo, H., & Abranches, J. (2013). Streptococcus mutans: A new gram-positive paradigm? Microbiology Maruyama, T., Jiang, M., & Hsu, W. (2013). Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development. Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research

Meirelles, L., Branemark, P. I., Albrektsson, T., Feng, C., & Johansson, C. (2013). Histological evaluation of bone formation adjacent to dental implants with a novel apical chamber design: Preliminary data in the rabbit model. Clinical Implant Dentistry and Related Research Meirelles, L., Uzumaki, E. T., Lima, J. H., Muller, C. A., Albrektsson, T., Wennerberg, A., & Lambert, C. S. (2013). A novel technique for tailored surface modification of dental implants - a step wise approach based on plasma immersion ion implantation. Clinical Oral Implants Research Papadimitriou, D. E., Schmidt, E. C., Caton, J. G., & Romanos, G. E. (2013). Morphology of bone particles after harvesting with 4 different devices. Implant Dentistry Romanos, G. E., Malmström, H., Feng, C., Ercoli, C., & Caton, J. (2013). Immediately loaded platform-switched implants in the anterior mandible with fixed prostheses: A randomized, split-mouth, masked prospective trial. Clinical Implant Dentistry and Related Research Watson, G. E., van Wijngaarden, E., Love, T. M., McSorley, E. M., Bonham, M. P., Mulhern, M. S., Myers, G. J. (2013). Neurodevelopmental outcomes at 5 years in children exposed prenatally to maternal dental amalgam: The Seychelles child development nutrition study. Neurotoxicology and Teratology Nkcc1 ion transporter expression in the submandibular gland. In the nanoparticle study Nkcc1gene knockdown was measured after siRNA injection into the gland. Salivary gland cells are outlined in red, while progenitor cells are stained blue/pink. Photo courtesy of Szilvia Arany.

momentum | 2014 . volume 1 31

Eastman Institute for Oral Health 625 Elmwood Avenue Rochester, NY 14620-2989

Address Service Requested

Upcoming Events March 19-22, 2014 43rd Annual Meeting of the American Association for Dental Research (AADR) Alumni & Friends Reception Charlotte, NC Contact: 585-273-2766

April 4, 2014 Oral Medicine Conference - A Three Continent Perspective Farash Auditorim, Eastman Dental Rochester, NY 14623 Contact: 585-275-9214

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ROCHESTER, NY PERMIT NO. 780

April 25-29, 2014 Annual Meeting of the American Association of Orthodontists (AAO) Alumni & Friends Reception Ernest N. Morial Convention Center 900 Convention Center Blvd. New Orleans, LA 70130 Contact: 585-273-3340

June 13, 2014 36th Allen A. Brewer Conference & Dinner Keynote Speaker: Dr. William c. Martin Doubletree Hotel 1111 Jefferson Road Rochester, NY 14623 Contact: 585-275-5043

May 9, 2014 20th Annual Handelman Conference and Dinner Keynote Speaker: Dr. Pascal Magne Doubletree Hotel 1111 Jefferson Road Rochester, NY 14623

June 12, 2014 Prosthodontic Clinic Dedication Time TBD

May 24, 2014 67th Annual Meeting of the American Academy of Pediatric Dentistry (AAPD) Alumni & Friends Reception Hynes Convention Center Sheraton Boston Hotel HQ 900 Boylston Street Boston, MA 02115 Contact: 585-273-2766

June 27, 2014 Dentistry Convocation Class of ’62 Auditorium Kornberg Medical Research Bldg Rochester, NY Contact: 585-275-9214

Save the Date!

Eastman Institute of Oral Health Momentum 2014 volume 1

Articles inside

Publications

News & Notes

A Special Tribute

First Caton Fellow

Shelter in a Patient’s Storm

Center for Oral Biology Update