Florey 2024 Annual Report

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Annual Report 2024

Acknowledgement of Country

The Florey acknowledges the Traditional Owners of the land on which we work, the Wurundjeri people of the Kulin Nation. We pay our respects to their Elders past and present.

The Florey is committed to the aims, principles and actions of marra ngarrgoo, marra goori: The Victorian Aboriginal Health, Medical and Wellbeing Research Accord.

Lived Experience Contributors and Volunteers

The Florey acknowledges those with a living or lived experience of neurological conditions and thanks them for sharing their stories and perspectives with us, as we work together to improve health outcomes and patient care.

We thank those who support Florey research and participate in our clinical trials.

A message from our Chair

I am pleased to present the 2024 Annual Report of The Florey Institute of Neuroscience and Mental Health. The Annual Report is published in tandem with the 2024 Impact Report which highlights our major research advances.

The past year has been a transformative one for the Institute, marked by a key leadership transition, strategic renewal and significant advances in research that have high promise to improve the lives of people living with brain and mental health conditions.

In August 2024, Professor Peter van Wijngaarden took over from Professor Trevor Kilpatrick as Executive Director and CEO of the Florey.

Peter's experience and visionary leadership have already proven invaluable in guiding The Florey through this important period of transformation. Under his stewardship, we have refined our research priorities, fostering greater collaboration and a renewed focus on research with translational impact.

We paid tribute to Professor Kilpatrick for his distinguished leadership of The Florey for more than six years in the roles of Executive Director and Clinical Director. He has been instrumental in facilitating a smooth transition of leadership and remains a valued member of our research team and a great friend of the Institute.

We also saw the retirement of three Board Directors, Mr Ross Oakley OAM, Mr Stephen Spargo AM and Mr Adam Horsburgh, who have all made significant contributions to The Florey. We were also delighted to welcome The Honorable Gabrielle Upton to the Board.

2024 will be remembered as the year of Florey innovation. Over the past 5 years the Institute has focused on moving scientific discoveries from the laboratory into the clinic.

We made substantial progress with the Australian Epilepsy Project funded by a $30m Medical Research Future Fund (MRFF) Frontiers grant, now a national platform connecting nearly 1000 patients with 130 neurologists across all states and territories pioneering delivery of the digital health transformation.

Supported by a talented commercialisation team, a Florey spin-out company, Alkira Bio, secured substantial venture capital funding and two other companies, Phrenix Therapeutics and Centron Bio, were in the advanced stages of seeking investment. Clinical studies of sodium ascorbate for sepsis showed

tremendous promise and research identified a role for the treatment in reducing the risk of delirium and dementia following heart-lung bypass. Further studies are underway to advance these transformative Florey discoveries. We are very proud of the significant progress that has been made in 2024.

These achievements were made possible with the support of volunteers, generous donors and funding agencies, as well as a wide array of research collaborators.

On behalf of the Board, I thank you for joining us on our mission to improve the lives of those living with mental illness and brain diseases.

Together, we will continue to push the boundaries of neuroscience, unlocking new frontiers of knowledge and transforming lives for generations to come.

A message from our Director

In August 2024 I had the great honour of joining the Florey and I am sincerely thankful for the warmth of the welcome that I have received.

I had the fortune of following in the footsteps of Professor Trevor Kilpatrick and I have continued to benefit from his wise counsel and generous support. Over the past months I have been struck by the extraordinary depth and breadth of talent amongst our researchers and professional staff. For many the mission to improve the detection, treatment and prevention of mental illness and brain diseases is deeply personal – they have experienced the awful toll of these diseases on their friends and family members, and this has hardened their resolve to make a difference.

Working at the frontiers of knowledge of the brain is a challenging endeavour; unforeseen obstacles and false avenues are common. Through a combination of intelligence, hard work and resilience our researchers have continued to make major advances, many of which are outlined in the Impact Report that accompanies this document. A common thread that

binds these achievements together is the focus on research with impact.

The efforts of our researchers are matched by those of our support staff – talented individuals working in finance, communications, information technology, laboratory services, commercialisation, human resources, student services and more. None of these extraordinary research advances would be possible without their dedication.

Collaboration is another contributor to the progress that our researchers have made over the past year. We are particularly indebted to our research partners at the University of Melbourne, the Austin and Royal Melbourne Hospitals, and to the many volunteers who participated in our clinical research studies.

2024 has been a year of significant challenges in the medical research sector. Rising costs and a reduction in grant support for research salaries have placed pressure on institutes. With challenges come opportunities. Judicious financial management and continued grant success, coupled with a robust stream of commercialisation revenue and the generous support of our donors, has enabled our researchers to remain at the forefront of discovery.

An independent scientific review of the Institute conducted by a panel of eminent researchers, led by Professor Sam Berkovic, informed an organisational restructure and the prioritsation of 5 key research areas. These are: dementia; neurodegeneration & immunology; stroke & critical care; epilepsy & neurodevelopment; and mental health. Each of our researchers has a main focus on one of these priorities, and shares knowledge with those in other priority areas.

Advances in data science enabled by the rise of artificial intelligence have accelerated research progress. The Florey is keen to take a leadership role in the application of artificial intelligence in neuroscience and will establish a technology & AI subcommittee of the Board to inform the strategy.

As I look to the year ahead with great optimism, I would like to express my sincere gratitude to the Board of Directors for their leadership and guidance. I extend these thanks to the Executive Team, and I applaud the dedication of our researchers, professional staff and students. We are thankful for the support of the Victorian Government, grant funding agencies and for the generosity of our donors. Together, we will continue to discover ways to improve brain health.

The Florey mission

The Florey Institute of Neuroscience and Mental Health is an independent medical research institute devoted to tackling brain and mental health conditions.

Our mission is to improve the lives of people affected by brain and mental health conditions through research. We envisage a world where early detection and timely intervention mean these conditions are preventable or treatable, so that we can all live full and healthy lives.

The Florey: 2024 at a glance

958

publications

Published research

Grants

57

new grants totalling $25m

55.5 million

7

grants of more than $1m

average annual citations past 2 years

4

68,590 >2000

NHMRC, 1 ARC and 2 MRFF grants

people reached with news from The Florey across all forms of media

Support for The Florey

Commercialisation

Community engagement Our people

1800

philanthropic gifts and bequests totalling $3.6m

4

start-up companies, raising more than $25m in capital

1,640

donors. 20% gave for the first time

people attended our public lectures

57

research teams

38

commercial contracts

40

projects supported by philanthropy, trusts and foundations

6

patent families

460

staff

225

students

A year in review 2024

Mar

Jan Feb

A study, led by Professor Christopher Rowe (above), brings us one step closer to a blood test ‘game-changer’ for diagnosing dementia.

We mourn the passing of Harold Mitchell AC, (above). Harold served as Board Chair from 2012 to 2020, was a tireless advocate of The Florey and a very generous donor.

Professor Anthony Hannan and Dr Carolina Gubert lead a study revealing the positive effect of a high-fibre diet for families with Huntington’s disease.

Associate Professor Justin Rubio is awarded significant funding from MS Australia for research aimed at slowing or preventing progression of multiple sclerosis.

The Hon Mark Butler MP (above), Minister for Health and Aged Care, attends The Florey's public lecture and speaks about the prevalence of dementia in Australia.

The Hon Gabrielle Upton is welcomed as a new Board Director.

Associate Professor Jess Nithianantharajah (above) is appointed Head of The Florey Department, University of Melbourne. Dr Pratishtha Chatterjee receives a MidCareer Researcher Fellowship from Dementia Australia and receives the coveted Dementia Advocates’ Award. We celebrate International Women’s Day with a panel of speakers.

Apr May Jun

The Hon Ingrid Stitt, Minister for Mental Health (above), visits to see the transformative impact of the Victorian Government’s Mental Health grant.

The Hon Ben Carroll MP, Victorian Minister for Medical Research, The Hon Enver Erdogan MP and Sheena Watt MP tour our motor neurone disease labs.

The Australian National Creutzfelt-Jakob Disease Registry receives a grant of $3m over 5 years from the Australian Government.

The Motor Neurone Disease Group (above), led by Professor Bradley Turner, joins FightMND’s Big Freeze 10.

We thank retiring Board Directors Ross Oakley OAM, Stephen Spargo AM and Adam Horsburgh for their tremendous contributions.

Associate Professor Dana Wong (above) speaks at a Parliamentary Breakfast hosted by The Young Stroke Service and attended by parliamentarians, including Emma Vulin MP.

Professor John Furness (above) is made an Officer of the Order of Australia (AO) in the 2024 King’s Birthday Honours List.

The Florey Graduate Research Symposium provides 4 insightful days of presentations and discussions.

Florey’s biotech spin-out, Alkira Bio, secures investment funding from USbased venture capital company Curie.Bio.

The Florey incorporates Centron Bio, led by Florey researcher Associate Professor Fazel Shabanpoor and Professor Bradley Turner, to translate its blood-brain barrier technology to the clinic.

July Aug Sep Oct Nov Dec

Florey Fellowships are awarded to Dr Laura Vella, and Professor Akhter Hossain (above), and Professor Anne-Louise Ponsonby (not pictured), providing salary support to enable impactful research.

Dr Niamh Moriarty (above right) is awarded the Flack Fellowship to fund her preclinical research in Parkinson's disease. Florey sepsis researchers demonstrate that a formulation of sodium ascorbate may reverse organ failure caused by sepsis.

Professor Peter van Wijngaarden (below right, with Florey Board Chair Martin Adams) appointed as The Florey’s new Executive Director and CEO.

Florey researchers led by Professor Anne-Louise Ponsonby and Dr Wah Chin Boon find an association between prenatal exposure to plastics and autism in some boys.

Florey-led startup, FeBI Technologies, receives funding from the Department of Education’s Australia Economic Accelerator.

The Australian Stroke Clinical Registry (AuSCR) at The Florey is awarded a new 3-year $1.5m funding package under the National Clinical Quality Registry Program.

Record numbers at our Student Open Day (above) with more than 300 attendees.

The Florey Awards recognise staff, student and volunteer excellence.

Dr Chris Bye and team are awarded $5m from the Medical Research Future Fund to screen potential treatments for motor neurone disease.

The Florey’s Centre of Research Excellence for Delivery of Organ Support (CREDOS) receives Good Laboratory Practice certification from the National Association of Testing Authorities.

The Florey Postdoctoral Association Symposium (above) is held with engaging presentations highlighting innovative research.

Dr Ya Hui Hung (above) and team investigate whether an mRNA gene therapy can be used to restore neurological function in people with the NiemannPick Disease, with support from the Australian NPC Disease Foundation.

We hold a tribute event to thank Professor Trevor Kilpatrick (above) for his exceptional leadership, as recently retired Director of The Florey.

MND researchers Associate Professor Fazel Shabanpoor and Dr Samantha Barton receive more than $1.1m in combined funding from FightMND.

An external Scientific Review of the Institute sees eminent Australian and international research leaders appraise Florey research programs and strategic direction.

Professors Scott Ayton, Ashley Bush, Colin Masters and Christopher Rowe are recognised for their significant impact on the global scientific community in the Clarivate Highly Cited Researchers List for 2024.

The Florey’s annual Melbourne Brain Symposium brings more than 200 attendees together to showcase scientific, clinical and industry partnerships for brain research.

The Florey’s ‘More Time’ summer fundraising campaign launches.

The NHMRC awards Ideas grants to Professor Akhter Hossain to study a gut hormone; Dr Niamh Moriarty to study neural grafts to treat Parkinson’s disease; and Professor Robin McAllen to map the brainstem and sympathetic nerve pathways.

The first episode of The Brain Matters Podcast is aired to a large audience of subscribers.

Our Impact

At The Florey, we are committed to translating discovery neuroscience into real-world outcomes for improved health. As global leaders in their fields, our researchers strive to understand brain diseases and mental illness, developing tests, devices and treatments to improve lives.

This Impact Report shares some of our recent breakthroughs. Go to Florey.edu.au/about/reports-and-publications/

Sepsis

A new treatment developed by Florey researchers, in collaboration with intensive care specialists could soon become a lifesaving, low-cost treatment for sepsis. Sepsis occurs when the immune system has an extreme response to an infection, leading to life-threatening reductions in blood pressure and multiple organ failure.

Pioneering research led by Professor Yugeesh Lankadeva and Professor Clive May has shown that the treatment can reverse the devastating effects of sepsis. An early phase clinical study showed great promise and a larger follow-on clinical trial is underway in intensive care units around Australia.

The Australian Epilepsy Project

A groundbreaking Florey research project, led by Professor Graeme Jackson, is transforming the diagnostic and treatment journey for people with epilepsy. The team is implementing a new standard of care that simplifies the journey from diagnosis to treatment.

Will Campbell’s (right) epilepsy went undiagnosed for years, but thanks to the AEP, he underwent brain surgery and his seizures are under control.

Brain cancer

Professor Lucy Palmer leads research to understand how healthy brain cells and cancer cells communicate.

“Cell by cell, we can create pictures of brain cancers by filling them with fluorescent markers and by measuring their electrical activity," Professor Palmer says.

Melbourne woman Janet Micallef has had 8 surgeries to remove brain tumours.

“I hope that with research like this, the way brain tumours are treated in the future will change for the better,” she said.

Genetic epilepsy

While studying biomedical science, researcher Montanna Waters became a support worker, caring for children living with complex disabilities.

Her care work inspired her to study childhood epilepsy at The Florey.

“Who better to work on finding a treatment for our kids than someone who knows them?” says the girls’ mother Danielle Williams.

Essential tremor

In just a few hours Richard Mulcahy was transformed from a man whose hands shook so much that he could not write or button a shirt, to somebody who could happily drink a cup of tea without spilling a drop. Richard underwent an incision-free brain procedure called MRI-guided focused ultrasound thanks to a collaboration between The Florey and the Austin Hospital.

"It's rapid, dramatic, and transformative,” says Austin Hospital neurologist and Florey researcher Associate Professor Thevathasan.

Plastic and autism

Plastic chemicals are now so widespread that no matter how hard we try – it’s almost impossible to avoid them. Professor Anne-Louise Ponsonby and Dr Wah Chin Boon are investigating some of the ways in which these synthetic substances affect the brains of children before they are born. The researchers have discovered a link between maternal exposure to bispehnol A (BPA) and autism in some boys.

“We are exposed to plastic chemicals in countless ways. It’s critical that we investigate human health effects so that international lawmakers can act now to safeguard global health, particularly for vulnerable groups,” Professor Ponsonby says.

Stroke

After a stroke, the time it takes for a patient to receive a thrombectomy - a surgical procedure to remove a clot from the brain – is critical. For stroke survivor Mike Lugg, that time was only 44 minutes. “Soon after the surgery I was sitting up in bed talking to people, and it was like nothing had ever happened - I’ve lived a perfectly normal life since,” he says.

Stroke researcher Professor Dominique Cadilhac says that’s a remarkable outcome. She leads research that is helping hospitals around Australia improve stroke care, ensuring that the quality of care is not a postcode lottery.

Multiple sclerosis

For 25 years, Associate Professor Rubio has been focussed on uncovering the genetic basis of multiple sclerosis (MS). This dedication, and the efforts of a multidisciplinary team of researchers and clinicians, has led to the discovery of an important mechanism by which inflammation in people with MS might damage neurons.

The team found that inflammation appears to speed up the rate of change (mutations) in the genetic code (DNA) of neurons and that this may contribute to their death.

Dementia

Professor Scott Ayton is leading a major new dementia research program – the Enhanced Dementia Diagnosis study – which will give people suspected to have dementia rapid access to the latest diagnostic tools, including the new blood test, advanced magnetic resonance imaging (MRI) and a digital cognitive function test.

“We are testing the performance of diagnostic tools in real-world settings to enable fast, accurate and equitable dementia diagnosis across Australia,” Professor Ayton says.

Awards and Achievements

Our scientists are committed to excellence within the Institute and beyond, with recognition from leading organisations around the world for their dedication to advancing humanity through brain research.

Recipient

Dr Roberta Anversa

Dr Lauren Bleakley

Dr Wah Chin Boon

Dr Wah Chin Boon for Meizon Innovations

Alayna Caruso

Centre of Research Excellence for Delivery of Organ Support

Dr Pratishtha Chatterjee

Prof Steven Collins

Samuel Combes

Dr Vincent Dore, Honorary Research Fellow

Tyra Fraser

Dr Carolina Gubert

Recognition

Best Early Career Research Paper Award

Awarded by

Biological Psychiatry Australia

BioCurate Best Lightning Talk Melbourne Emerging Leaders in Biomedical Research Symposium

Launching New Ventures Pitch Night Grand Master Champion

Most Innovative Company 2024

Best Oral Presentation

Good Laboratory Practice recognition

Dementia Advocates’ Award

Legend Award

2024 Karl David Yeoman’s Award

de Leon Prize in Neuroimaging

2024 AusHealth CureCell Award

Young Scientist Award

Harvard Business School

Club of United Business

2024 Melbourne Protein Group Student Symposium

National Association of Testing Authorities

Dementia Australia

Creutzfeldt-Jakob disease Support Group Network

University of Melbourne

Alzheimer’s Association International Conference

AusHealth CureCell

Federation of Asian and Oceanian Biochemists and Molecular Biologists

Recipient

Recognition

Prof Trevor Kilpatrick For Excellence in Academic Career Achievement Award

Prof Yugeesh Lankadeva Finalist in the Asian-Australian Leadership Awards (Education, Science & Medicine)

Prof Yugeesh Lankadeva Jaye-Chin Dusting Award

Katherine Lewis

Xavier Maddern

Prof Catriona McLean AO and Prof Jane Gunn AO

Dr Chiara Pavan

Andrew Quattrochi

Prof Christopher Reid

Dr Robert Smith for MRtrix3

James Tran

Istvan Tork Student Oral Award

ECRN Excellence Plenary Award

Induction into the 2024 Victorian Honour Roll of Women

Best Early-to-Mid Career Researcher Presentation

Dibbens Family CureCell Award for Stroke Research

Scientific Merit Award

Finalist in the Eureka Prize (Research & Innovation)

Early-Stage

Awarded by

Australian and New Zealand Association of Neurologists

University of Melbourne Asialink and Johnson Partners

2024 Hypertension Australia Conference

Australasian Neuroscience Society 41st Annual Scientific Meeting

Biological Psychiatry Australia

Victoria Department of Families, Fairness and Housing

Australasian Society for Stem Cell Research Conference, Adelaide

AusHealth CureCell

Epilepsy Society Australia

Australian Museum

Florey staff and student awards

Celebrating the achievements of our staff, students and volunteers

“These awards recognise members of the Florey community for their outstanding contributions to the Institute and for their pursuit of research impact” – Executive Director and CEO Professor van Wijngaarden.

Florey Medals for Outstanding Contribution

The Outstanding Contribution awards to recognise the efforts of volunteers at The Florey.

Longstanding volunteers, Peter Maley and Bruno Marino, were awarded the inaugural Florey Medals for Outstanding Contribution.

Peter Maley joined the Florey Institute’s Animal Ethics Committee in 1993 in a voluntary capacity and remained in that role for 31 years, retiring only last year.

2024 Florey Award winners

Exceptional Talent Award

This award is for someone who goes above and beyond in their role and shows dedication to the Institution and to their colleagues.

Winner: Dr Samaneh Mirzaei

The late Bruno Marino volunteered from 2014 to 2024 generously donating time and expertise to projects in the pre-clinical Critical Care Unit.

Pathway to Impact Award

This award is for someone who drives meaningful change, a commitment to improving the lives of people in Australia and around the world through their research.

Winner: Professor Yugeesh Lankadeva

Dynamic Collaborator Award

This award is for someone who sets a high standard for building relationships and has a strong track record of successful collaboration.

Winner: Kath Powley

Winner: Professor Akhter Hossain

Lend a Hand Award

This award is for someone who provides outstanding support for others and plays a vital role in making things work.

Winner: Sarah Handcock

Winner: Dr Marius Rosier

Team of the Year Award

This award goes to a team that demonstrates great teamwork, team spirit and successfully delivers outcomes for The Florey.

Winner: Core Animal Services

Length of service awards

15-year milestone: Professor Colin Masters

10-year milestone: Professor Chris Bladin, Shannon Currin, Krista Dent, Professor John Furness, Dr Sarah Gordon, Kristen Grant, Benny Gregersen, Dr Nicole Jenkins, Dr Timothy Karle, Professor Yugeesh Lankadeva, Shanshan Li, Dr Sophia Luikinga, Celeste Mawal, Sean Murphy, Associate Professor Jess Nithianantharajah, Kate Paice, Dr Nirma Perera, Dr Eric Pierre, Nancy Pompeani, Dr Philip Ryan, Christine Thai, Shiji Varghese, Dr Laura Vella

Donor-sponsored

Awards

These travel awards were made possible thanks to the generosity of our donors. We thank them for their continued support.

John Milne Prize for Neuroscience

Winner: Dr Tina Kaffenberger

Philanthropic Postgraduate and Postdoctoral Travel Awards (Anonymous Donor)

PhD Winners: Anton Trask-Marino, Aida Viden, Hongkang Wu

Postdoc Winners: Dr Niamh Moriarty, Dr Connie Ow, Dr Chaitra Chandrashekar

Caitlin’s Fund Postgraduate and Postdoctoral Travel Awards

PhD Winner: Suyi Ooi

Postdoc Winner: Dr Jodie Chapman

Harold Mitchell Postgraduate and Postdoctoral Travel Awards

PhD Winner: James Spyrou

Postdoc Winner: Dr Emily Ramage

Wally and Jean Jackson Postgraduate and Postdoctoral Travel Awards

PhD Winner: Joshua Saito

Postdoc Winner: Dr Ruslan Pustovit

John Collier Postdoctoral Travel Scholarship

Winner: Dr Chiara Pavan

Florey-sponsored Awards

Alan Rembach Postdoctoral Travel Award

Winner: Dr Ashenafi Betrie

Graduate Research Symposium Overall Winner Winner: Hongkang Wu

Graduate Research Symposium Innovation Award

Winner: Vicky He

Graduate Research Symposium 2nd Year Talk

Winner: Montanna Waters

Runner up: Hian Mun Lee

Graduate Research Symposium 3rd Year Talk

Winner: Andrew Zhang

Runners up: Katie Lewis and Anthon Trask-Marino

Florey Postdoctoral Association Best Paper

Winner: Dr Alemayehu Jafar

Runners up: Dr Alaa Abdul-Ridha and Dr Roberta Goncalves Anversa

The Craig Drummond Award

Winner: Dr Maria Kuznesova

Scientific Postdoctoral Travel Award

Winner: Dr Madeleine Di Natale

Ayse Berke and Liana Colvill Postgraduate Travel Award

Winner: Sam Tanner

Neuropix

The Florey’s annual microscopy photography competition, where cutting-edge science and artistic brilliance collide. The images showcase the critical role microscopy techniques play in advancing our understanding of the brain’s structure and function.

Scientific Award Winner: Montanna Waters People’s Choice Award Winner: Dr Chiara Pavan

Philanthropic Postdoctoral Travel Award winners: L-R Anton Trask-Marino, Aida Viden, Hongkang Wu, with Professor Peter van Wijngaarden Executive Director & CEO, The Florey

The Florey Board of Directors

We thank our dedicated Board of Directors for their expert guidance and valuable contributions to The Florey.

Mr Martin Adams – Chair

Technology entrepreneur, investor and company director. Joined the Board in 2021, appointed Chair in 2022. Serves on Audit, Risk & Governance, Investment and Commercialisation Committees.

Mr Graeme Billings

Chartered accountant and former senior partner at PwC with over 30 years’ experience. Honorary Treasurer and Chair of the Audit, Risk & Governance Committee.

Mr Chris Blake

Transformation leader and current Group CEO of St Vincent’s Health Australia. Also serves on the Advisory Committee of the Australian Epilepsy Project.

Mr Ross Burney

Experienced investment professional with a global background in equities, debt, private equity and property. Chair of the Investment Committee.

Professor Jane Gunn

Medical practitioner and Dean, Faculty of Medicine, Dentistry and Health Sciences at the University of Melbourne. Champion of innovation, governance and collaborative research.

Mr Peter Haig

A partner at Allens. Highly respected specialist in regulatory investigations, inquiries, and complex commercial disputes. Serves on the Audit, Risk & Governance and Investment Committees.

Professor Mark Hargreaves AM

Former Pro Vice-Chancellor (Research Collaboration & Partnerships) at the University of Melbourne, focused on fostering interdisciplinary research and strategic partnerships.

Ms Kate Joel

Strategic consultant with 30+ years’ experience across industry and government. Serves on the Audit Risk & Governance Committee. Chairs the Fundraising Committee.

Professor Christine Kilpatrick AO

Former CEO of Melbourne Health, epilepsy neurologist, and respected health leader. Chair of the Australian Commission on Safety and Quality in Health Care. Retires from the Board in May 2025.

The Hon Gabrielle Upton

Lawyer, banker and former government minister. Was the first female NSW Attorney General and Deputy Chancellor of UNSW. On the Audit, Risk & Governance Committee. Chairs the Commercialisation Committee.

Professor Peter van Wijngaarden

Clinician-scientist and research leader, formerly Deputy Director at CERA. Joined The Florey on 1 August 2024. Driven to create health impact through research.

Directors retired in 2024

The Florey is grateful for the dedicated service of Board Directors who retired in 2024:

• Professor Trevor Kilpatrick

• Mr Adam Horsburgh

• Mr Ross Oakley OAM

• Mr Stephen Spargo AM

Incoming Directors

We look forward to welcoming new Board Directors in 2025.

• Professor Shelley Dolan – Chief Executive, Royal Melbourne Hospital

• Ms Jodie Geissler – Chief Executive Officer, Austin Hospital

Thanks to our supporters

A message from Ms Kate Joel, Chair of the Florey Fundraising Committee

At The Florey, our critical research is enabled by our passionate and generous donors, community groups, and philanthropic foundations committed to advancing brain health for future generations.

As Chair of the Fundraising Committee, I extend my heartfelt thanks to all who supported us in 2024. Whether you hosted an event, donated, or included The Florey in your Will, your contribution has made a profound impact.

Your support empowers us to unlock the brain's mysteries, create new diagnostic tools, and develop treatments that improve lives daily. Every donation helps us to realise our mission.

2024 marked significant milestones in fundraising:

• Our first Impact Report shared stories of lives changed by Florey research.

• The Brain Matters podcast reached new audiences with powerful, accessible conversations.

Florey Governors

Andrew Abercrombie

Martin Adams

James Angus AO

Etienne Baulieu

Samuel Berkovic AM

Graeme Billings

Christopher Blake

Neal Blewett AC

Graeme Bowker

Di Bresciani OAM

Alec Broers

Malcolm Broomhead AO

John Brumby AO

Tom Buchan

Ross Burney

Edward Byrne AC

Lyndsey Cattermole AM

Jean-Pierre Changeux

Trevor Clark OAM

Peter Clemenger AO

David Copolov AO

Philip Cornish AM

Charles Curwen AO CVO OBE

Andrew Cuthbertson AO

Tim Daly AM

Stephen Davis AO

Jerry de la Harpe

David de Rothschild

• Our More Time appeal, highlighted groundbreaking dementia research by scientists with deeply personal connections to the disease.

Community fundraising made a profound impact, with Super Dad Stu Place’s 50-day cycling challenge raising over $350,000 for research into chilldhood epilepsies; and The PURA Foundation Australia’s tireless support advancing our understanding of PURA syndrome.

I am especially grateful to Allan Myers AC KC and Maria Myers AC for enabling three Philanthropic Fellowships and supporting the 2024 Allan and Maria Myers Lecture.

I extend my heartfelt gratitude to Carl Dowd AM and Wendy Dowd AM, whose vision created the Florey Future Fund and the Carl and Wendy Dowd Professorial Fellowship, providing critical support to our leading scientists.

With your support we are building a foundation for world-leading innovation, sustainable research, and lasting impact. Thank you for your support in 2024. Your kindness means the world to us.

David de Souza AM

Peter Doherty AC

Carl Dowd AM

Wendy Dowd AM

Suzanne Downes

Craig Drummond

George Fink

Alan Finkel AC

John Finlay-Jones

Roger Flynn

Tamie Fraser AO

Peter Fuller AM

John Funder AC

Rob Gerrand

Kelvin Glare AO

Charles Goode AC

Susan Greenfield CBE

Jane Gunn AO

Sandra Hacker AO

Peter Haig

Mark Hargreaves AM

Pamela Hauser

Caroline Hogg AO

Adam Horsburgh

Andrea Hull AO

Margaret Jackson AC

Bevyn Jarrott

Kate Joel

Barry Jones AC

Mark Jones AM

Peter Jopling AM KC

Shitij Kapur

Graeme Kelly

Bruce Kemp AO

Christine Kilpatrick AO

Jennifer Labourne

Frank Larkins AM

Richard Larkins AC

John Lill OAM

Paul Little AO

Bernard Lochtenberg

Lina Marrocco OAM

Jim McCluskey AO

Elspeth McLachlan

George McMaster

Frederick Mendelsohn AO

Naomi Milgrom AC

Brendan Murphy AC

Louise Myer

Martyn Myer AO

Allan Myers AC KC

Maria Myers AC

Mark Nelson

Hugh Niall

Ross Oakley OAM

Simon Parker Bowles

Primrose Potter AC

John Poynter AO OBE

Ian Renard AM

Geoffrey Ripper

Eda Ritchie AM

John Rose AO

Thomas Schneider

David Scott

Richard Smallwood AO (dec)

Stephen Spargo AM

Andrew Stripp

Boris Struk

Geoffrey Tregear AM

Robert Trenberth AM

Gad Trevaks AM

Gabrielle Upton

Anne Ward

Andrew Wardlaw

Elizabeth Wardlaw

Brian Watson AO

Ingrid Winship AO

Marelyn Wintour-Coghlan AO

Meredith Woods

Michael Wooldridge

John Wylie AC

Harrison Young

Our donors in 2024

Founding benefactors

Kenneth Myer AC

Sir William Ian Potter

Future Fund donors

Principal Benefactors (above $3 million)

Carl Dowd AM and Wendy Dowd AM

Estate of Mary Lugton

Harold Mitchell AC (dec) Fellow

($250,000 – $499,999)

Lady Primrose Potter AC

Associate

($100,000 – $249,999)

Lindsey Cattermole AM

The Drummond Foundation

GSA Industries Pty Ltd

Omnico Operations

Estate of Marjorie Talan and Akos Talan

The A N and B O Williams Foundation

Florey Foundation donors

Deirdre Collier

Caitlin's Fund

Estate of Dorothy Jean Jackson

Naomi Milgrom AC

John Milne

Harold Mitchell Foundation

Allan Myers AC KC and Maria Myers AC

Our donors in 2024

Donors with gifts of $10,000 to $999,999

Peter Armstrong

John and Lorraine Bates

Berwick Opportunity Shop Incorporated

Julie Blunt

David Carroll

Lisa Carroll

Peter Carroll

Roslyn Glow OAM

Lesley Griffin

Hearts and Minds Investments

Limited

Kate and Warren Joel

Trevor Kilpatrick

Richard Lake

Maureen List

Anne Mattingly

James McIntyre

Bruce and Lana Moran

Mort & Co Ltd

Judy Overbeek

Richard and Juneth Wall

The Hunter's Fundraising Group

Kay Tudor

Donors with gifts of $1,000 to $9,999

David Aitken

Jim and Judy Allen

Pauline Atkins

Nicholas Barton

Mirion Bearman

Cathy Bell

Matthew Benson

Jonathan Benson

Garth Bird

Bisping Medizintechnik GmbH

Angelo Bladeni

The Cornelis and Trish Boekel

Family

Mary Bram and Arnold Bram (dec)

Hazel Brentnall and Edward Brentnall OAM (dec)

D E and G M Brown

Grace Cavanagh

Centre State Rodders

Elaine Chang

Diana Cherry

Richard and Elizabeth

Chisholm

Peter and Jan Clark

Patricia Clennett

Dorothy Collin

Geoffrey Cottrell

Graham Cush

Eril Deighton

John and Dianne Dixon

Gwen D'Sylva

Susan Duncan

Dorothy Emerson

David Feldman

Janine Ferguson and Graeme

Ellen

Valmae Freilich

Gemma Furtado

Galig Nominees Pty Ltd

Jenny Galloway

David and Rosemary Geer

Peter and Janet Gilbertson

Wayne and Suzanne Gill

Dina Goldschlager

Goldsmith Family

Ai-Gul and Andrew Guild

Sandra Hacker AO

John Harrison

Robert Henwood

Annelie Holden

William Holdsworth

Doug Hooley

Inner Wheel Club of Pakenham

Susan Iovenitti

Rosemary Jenkins

K-OSSS Pty Ltd

Jillian Keetley

Ian Kennedy AM

Wesley Kilham

Peggy Knight

William Kosky

Bonnie Lee

Peter Lemon

Alison Leslie

Brian Little

Heather Mason

Ian McCay

Ingeborg McCullough

John McKenzie AM

Bruce McKenzie

Muriel McLaren

Victoria McNeilly

Elizabeth Mildwater

David Moeller

Kui Meng Ng

Anthony Nicholas

Heather Nixon-Smith

Greg Noonan

Valerie Osbourne

Pakenham Opportunity Shop

Inc

Dianne Pascoe

Mary Paterson

Patricia Peck (dec)

Elizabeth Pender

Duong Phan

Ian Phillips

Ron Pitcher AM

Richard and Glenda Power

Marlene Raven

RBR Refrigeration Services

Colette Reeves

Deborah Reich

Ralph and Ruth Renard

Caroline Richardson

Ritchies Victoria Pty Ltd

Judy Roach, Richard Roach and Sally Gough

Sharon Roberts

Caroline Robertson

Maree Robinson

John and Margot Rogers

Nicola Rollerson

Rotary Club of Rowville

Lysterfield

Betty Smith

Somnivore Pty Ltd

Luke Stevens

Gary Stiliano

Sheryl Summons

Dorothy Tagg

Gregory and Wendy Taggart

Jenny Tatchell

Wendy R Taylor

Kathryn Thaniel

The Grocer

Debbie and Peter Thomas

Linda Thomas

Wendy Thomas

Margaret Toomey

Toowoomba Turf Club

Paul Treasure

David Tregear

Devin Trussell

Henri van Reesema

John and Robyn Vroland

Philip Weickhardt

Karen Wells

Michelle Westaway

Janet Whiting AM

Stuart Wilson

Sineke Winter

Belle Wong

Susanna Woodall

Meredith Woods

Harrison Young

Trusts and foundations

Allan & Gill Gray

Philanthropies

Alzheimer’s Association (US)

Alzheimer’s Drug Discovery

Foundation

ANZAN Education and Research Foundation

A-T Children’s Project

AusHealth Cure Cell Awards

Australian NPC Disease Foundation

Australian Rotary Health

Austrian Science Fund

Bethlehem Griffiths Research Foundation

Brain Australia

Brain Cancer Centre

Brain Foundation

Caitlin's Fund

CJD Support Group Network

Dementia Australia Research Foundation

DHB Foundation

Emma & Bob House

Philanthropic Trust

Epilepsy Foundation

FightMND

Flicker of Hope Foundation

Ltd

Frick Foundation

Gaudry Gift

Givingforce Foundation

Harbig Charities Pty Ltd atf

Harbig Family Foundation

Harold & Cora Brennen Benevolent Trust

Harold Mitchell Foundation

Hereditary Disease Foundation

Homer Hack

J & J Grants

Jeanette Tye Webster Endowment

Johnstone Family Foundation

Judy Matear and Family

Lionel & Yvonne Spencer Trust

Live Life Foundation

Macular Disease Foundation

Australia

Mason Foundation

Massey Charitable Foundation

Menika Lanard Jandd

Charitable Foundation

Michael J Fox Foundation

Minderoo Foundation

MND Research Australia

MS Australia

National Foundation for Medical Research and Innovation

Nell & Hermon Slade Trust

Nigel & Patricia Peck Foundation

MND Research Australia –Daniel McLoone Research Initiative

Percy Baxter Charitable Trust

Pincus Family Foundation

Ralph and Betty Sims Fund

Rebecca L Cooper Medical

Research Foundation – Al &

Val Rosenstrauss Fellowship

Rob Clarke & Family Giving Fund

Robert and Elizabeth Sinclair Foundation

RobMeree Foundation

Santalum Foundation

Stroke Foundation

Stuart & Jillian Bales

Telematics Trust

The CASS Foundation

The Halim Family Perpetual Endowment Legacy

The Heart Foundation

The Hutchins Family

The Isabel & John Gilbertson Charitable Trust

The Jack Brockhoff Foundation

The Marchris Family Charitable Gift

The Marian and E H Flack Trust

The Mark Foundation

The Rix Foundation

The Roebuck Foundation

The Stafford Fox Medical Research Foundation

The Stuart Leslie Foundation

The Valda Klaric Foundation

The Will & Dorothy Bailey Charitable Fund

Tom and Ruth O'Dea Fund

Trish MS Research Foundation

Waterloo Foundation

Weary Dunlop Foundation

Trust

administrators

We acknowledge the services provided by these companies in administering grants and donations

Australian Communities Foundation

Australian Online Giving Foundation

Australian Philanthropic Services Foundation

Equity Trustees Limited

Lord Mayor's Charitable Foundation

Mutual Trust Foundation

Perpetual Trustees Australia

UK Online Giving Foundation

The Florey Society

Thank you to those supporters who have advised they have included a gift to The Florey in their Will

Peter Armstrong

John and Lorraine Bates

Sally Beavis

Dianne Berlin

Coral Beulke

Kate Brown

Tess Cafarella

Tina Cafarella

Lynne and Paul Cordon

Irene and Jeffrey Court

John Crutchfield

Barbara Darvall

Neville and Denise Daynes

Geraldine de Malet

Antoinette Doran

Joe Foley

Cathy Foster

Margo Garnon-Williams

Anna Gillard

Roslyn Glow OAM

Doreen and John GordonKirkby

Nancy Guzzo-Pernell

Frank and Swan Halim

Jean Hofmaier

Marie-Louise and Peter Hekel

Annelie Holden

Susan Hosken

Jenny Vallins and Anthony Jackman

Rod Kent

Helen Lightfoot

Caroline Lord

Elaine Mann

Peter McCarthy

Bruce McKenzie

Patricia McLoughlin

Kris Meade

John Milne

Lana and Bruce Moran

Christine and Garnet Morgan

Bob Muirhead

Judy Overbeek

Dianne Pascoe

Rita Pellen

Richard Pestell AO

Wayne Pethick and Donna

Walker

Sherry Pratt

David and Robin Richards

Geoffrey Ripper

Annette Rogers

Josephine Ridgeway

Alma Ross

Melanie Scaife

Kai Simpson

Marie Smyth

Ralph Stavely

Wendy R Taylor

Rod Thomas

Kay Thomas

David Tregear

Geoffrey Tregear AM

Kay Tudor

James Walduck

Richard and Juneth Wall

Robert White

Michael Wignell

Bev Womersley

Bequests and Estates

We acknowledge the donors from whom we received a gift through their Will in 2024 and express our appreciation to their family and friends

Christine Mary Adams

Margo Elizabeth Bartley

Elizabeth Mary Butt

Shirley Hallows

Katherine Kingsbury OAM

Marian Rosalind Letcher

Lois Elizabeth Oliver

Florey supporters raising funds in the community

Kellie Adams – NPC disease research

Annie's Birthday Fundraiser

Francesca Hargrave – Tour 2 Cure Schizophrenia

Rabbi Ian Morris - 70th Birthday Fundraiser

Scott Murphy and David Moeller – Walk to Fight Dementia

We would also like to acknowledge the donors to The Florey who wish to remain anonymous.

We have made every effort to ensure the details in this list are correct.

For any queries, please contact us on philanthropy@florey. edu.au.

Financial snapshot 2024

Review of operations

For the year ended 31 December 2024, total revenue from ordinary activities was $72.8m. The entity recorded a net operating deficit of $1.5m and a net deficit of $3.9m after depreciation, amortisation and change in fair value of investments.

A life’s gift to The Florey

A Melbourne couple’s many personal connections to conditions researched at The Florey have inspired them not only to provide support during their lifetimes, but to remember The Florey in their Wills.

Doreen and John Gordon-Kirkby know firsthand the difference scientific research could make to loved ones.

Sadly, John’s first wife, Ailsa died from motor neurone disease in 2018, and Doreen’s first husband suffered from depression before his death in his early 30s. They’ve also had family members diagnosed with schizophrenia, epilepsy and obsessive compulsive disorder – all conditions that are the focus of research at The Florey.

John born in Gibraltar, and Doreen, from Hong Kong, met in Melbourne and married in 1988, a second marriage for each. They eventually settled in Mornington.

It was a shock for the family when Doreen’s son David, after a happy childhood, was diagnosed with schizophrenia as a teenager.

At first, medication rendered him very sleepy and stiffened his muscles considerably.

“We both had to change our ways of thinking,” Doreen says. “Doing things and interacting with each other had to dovetail to maintain a new normal.”

For over a decade David was treated with injections as well as tablets.

“To his credit he never complained or missed an appointment.” Doreen says he is now living independently and she visits frequently.

Back in those pre-internet days Doreen read up on David’s condition, eventually discovering the work of the Mental Health Research Institute (now merged into The Florey).

“I was impressed by the dedication staff showed to a host of mental health diseases,” Doreen says.

Doreen says she’s been given many opportunities in life.

“It’s time for me to give back by supporting The Florey - during my lifetime as well as in my Will - so that researchers can spend less time applying for grants and more time on their science.”

Doreen and John enjoy good health and are avid volunteers. They concede that as they age, they need to keep an eye on their Wills and update them with changing family circumstances.

Both Doreen and John have included a gift for The Florey’s brain research in their Wills.

Doreen dearly hopes her bequest will help bring about effective treatments or cures for brain diseases such as schizophrenia and dementia.

John hopes The Florey will use his gift to find relief and cures for the many mental health afflictions experienced by those in our community.

The Florey Society acknowledges the generosity of Florey supporters who have committed to leaving a gift in their Will for brain research.

Doreen and John Gordon-Kirkby

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