PLOF June 2025 by sigmaplc

JUNE 2025 PROMOTIONS

PRICES VALID FROM 1-30 JUNE 2025

Introducing the FyboCalm range

FyboCalm helps RELIEVE and PREVENT gut symptoms recurring†1-4 FyboCalm

FyboCalm Wind & Bloating Relief

Relieves wind, bloating and abdominal pain in 2 hours, for relief up to 8 days 3

& Bloating and IBS type symptoms such as Constipation and Diarrhoea.

FyboCalm

Constipation Relief

REFERENCES: 1. Ciriza de los Rios CC, et al. Ther Adv Gastroenterol. 2021; 14: 1-10. 2. Trifan A. et al. UEG Journ. 2019: 7(8); 1093-1101. 3. Petrisor DC et al. Dig Dis Sci. 2024 Jan;69(1):161-168. 4. Etropolska Z, Poster presented at the Digestive Disease Week; 2023; May 6–9; Chicago, IL. 5. Filippone A, et al. J ClinMed. 2022; 11(23): 7073. Learn More about FyboCalm's Unique Mode of Action

RKT-M-47562 July 2024 FyboCalm is a medical device. Always read the instructions.

Powered by Xyloglucan

With only 1 week of use Treat

To maximise treatment outcome remind your patients to:

Apply LAMISIL ONCE to both feet

Spread evenly on toes, sole and sides of feet

Do not massage or rub

Do not wash feet for 24 hours

Athlete’s Foot

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Enhances Terbinaﬁne penetration by 2.5 times* 2.5 x

Days 13

Creates a reservoir that prolongs the fungicidal e ect of Terbinaﬁne for up to 13 days**

Helps destroy the fungus

Relieves symptoms

Helps Prevents recurrence

Find your natural balance

The UK’s No.1 BV Treatment*

How Balance Activ® BV Treatment Gel and Pessaries works:

Not a drug: Mimics the vagina’s own defence mechanism to treat and relieve BV, naturally.

Reliable: Clinically proven to work, for a dependable natural alternative.

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Balance: Tops up glycogen to encourage good bacteria and maintain pH balance to keep BV at bay.

Convenient: Available in 2 easy to use, 1 week course,formats -pessary & gel for added convenience.

Retail Category Management

Guidance and product information for OTC brands and categories to help support the pharmacy team.

Advising on

moderate to severe hay fever

Supporting customers when intranasal monotherapy has not provided relief

Around a quarter of the UK population suffer from seasonal allergic rhinitis (AR), or hay fever.1 Symptoms are generally managed through self-care strategies and over-the-counter (OTC) treatment with oral antihistamines and/or intranasal corticosteroids.2

Until now, the only alternative for customers with moderate to severe hay fever symptoms that remained uncontrolled on an OTC corticosteroid nasal spray would have been to obtain a prescription-only product. There were no combination treatments in a single product available to purchase from the pharmacy.

Dymista® Control combines the antiinflammatory action of a corticosteroid (fluticasone propionate) and the anti-allergenic effect of an antihistamine (azelastine hydrochloride) in one formulation to reduce bothersome hay fever symptoms affecting the eyes and nose.3 It offers faster and more complete control

About Dymista Control (P)

Dymista® Control indicated for the relief of symptoms of moderate to severe hay fever in adults (18+ years) if monotherapy with either intranasal antihistamine or corticosteroid is not considered sufficient. The recommended dosage is one spray into each nostril, twice a day (morning and evening). The maximum daily dose should not exceed two sprays in each nostril per day. It should be used regularly to achieve full therapeutic benefit.3

Key points about Dymista® Control:3

Unique

It is the ONLY double action nasal spray containing both a corticosteroid and an antihistamine available as a Pharmacy medicine

Fast

Gets to work in five minutes

Effective

Reduces inflammation in both nose and eye symptoms (nose symptoms comprising rhinorrhoea, nasal congestion, sneezing and nasal itching and eye symptoms comprising itching, tearing/ watering and redness of the eyes) compared to placebo, azelastine alone and fluticasone alone

Assessing your

customer’s symptoms

Typical hay fever symptoms appear within minutes of exposure to grass, tree and/ or weed pollen2 and can last for weeks, or even months.5

• Sneezing

• Bilateral nasal itching

• Nasal discharge (rhinorrhoea)

• Nasal congestion

• Accompanied by itchy, red, watery eyes

Mild symptoms are not considered troublesome and they do not have an effect on sleep, work, studies and other daily activities.2 However, symptoms are classified as moderate to severe when one or more of the following applies:2

l Disturbed sleep

l Problems at work or school

l Impairment of daily activities, sport or leisure

l Troublesome symptoms

Moderate to severe symptoms can lead to a reduced quality of life due to their adverse effects on people’s work, home and social lives.2 For young adults, this could affect performance during studies and exam periods.

Dymista® Control is a suitable option for customers suffering from moderate to severe hay fever symptoms, if monotherapy with either intranasal antihistamine or intranasal corticosteroid is

• Coughing

• Postnasal drip

• Itchy throat, mouth and ears

• Snoring / mouth breathing

• Halitosis

Alternative diagnoses

Other conditions may present with symptoms that are similar to hay fever. If any of these additional symptoms are present, you should consider an alternative diagnosis:2,6

l Fever that is not improving or worsening

l Persistent cough

l Unilateral symptoms

l Coloured nasal discharge

l Blood-stained nasal discharge

l Recurrent nose bleeds

l Nasal pain

l Loss of sense of smell

l Visual disturbances

These symptoms may indicate: other types of rhinitis; sinusitis; asthma; tuberculosis; nasal structural abnormalities; a blockage, such as polyps or the presence of a foreign body; a cardiovascular condition; obstructive sleep apnoea syndrome, or a chest infection. Dymista® Control is not suitable for any of these conditions and alternative therapies or referral to a GP should be considered.6

Considerations before

supplying Dymista®Control

l Dymista® Control is contraindicated in those with a hypersensitivity to any active ingredients or excipients3

l The following customers should be referred to their GP for assessment before using Dymista® Control:3

• Pregnant, suspected pregnancy or planning to have a baby

• Breastfeeding

• Severe liver disease

• Tuberculosis or any type of untreated infection

• Fever or infection in the nasal passages or sinuses

• Recent injury or surgery to the nose or mouth or problems with ulceration in the nose

• A history of increased ocular pressure, glaucoma and/or cataracts

• Those transferring from a systemic corticosteroid

• Those who have been using intranasal corticosteroids at high doses and/or for prolonged periods (3 months or more). They may be at greater risk of systemic effects, and more rarely, a range of psychological or behavioural effects. Customers experiencing any systemic effects must be referred to their GP

• Changes in vision (e.g. blurred vision or other visual disturbances) after using systemic or topical corticosteroids.

l Customers taking the following medicines should be referred to their GP before using Dymista® Control because they interact:3

• Other corticosteroid products, such as tablets, creams, ointments, asthma medications or similar intranasal sprays or eye/nose drops

• Medicines for HIV (ritonavir or cobicistat)

• Ketoconazole.

l Those taking sedatives/central nervous system (CNS) medicines (e.g. opioids, barbiturates, benzodiazepines, anxiolytics, sleep medications, hypnotics) should be warned of the potential increase in their sedative effect when used with Dymista® Control.3

Further advice when supplying Dymista

l Common or very common side effects include epistaxis (nosebleeds), headache, unpleasant smell and unpleasant taste3

l Correct application is important and will also help to avoid the unpleasant taste. Your customer should close one nostril with a finger and place the spray pump tip just into the other nostril; tilt their head forward slightly, open their mouth and take care not to spray directly onto the nasal septum (the wall between the nostrils); keep the bottle upright and mouth open while pumping once gently and breathing in lightly through the treated nostril.3

KEEP HEAD TILTED FORWARD

*Dymista® Control has minor influence on the ability to drive and use machines3

l Your customer may have combined their previous corticosteroid nasal spray with an OTC oral antihistamine. Dymista® Control combines an intranasal corticosteroid and intranasal antihistamine, therefore they should discontinue their other oral and intranasal hay fever medication

l When using Dymista Control, customers should seek medical advice in case of:

• A severe allergic reaction (very rare)

• Blurred vision or other visual disturbances

• Discomfort due to irritation or swelling inside the nose.

Key information about

treatment duration

Your customer’s symptoms should be assessed within seven days of starting Dymista® Control. If their symptoms are not well controlled, they may not have hay fever:3

l If Dymista® Control does not lead to an improvement in symptoms within seven days, your customer should stop treatment or seek advice from their GP

l If, within seven days, symptoms have improved but are not adequately controlled, they should also seek advice from their GP or return to the pharmacy.

Dymista® Control should not be used for more than three months continuously without consulting a GP.

References:

1. Natasha Allergy Research Foundation. Allergies - The facts. 2025. https://www.narf.org.uk/the-allergy-explosion

2. NICE. CKS. Allergic rhinitis. 2024. Available at: https://cks.nice.org.uk/topics/allergic-rhinitis/

Control

To complete your learning, please refer to the following materials:

3. Dymista Control 137 microgram, 50 microgram nasal spray. SmPC. 2025. Available at: https://www.medicines.org.uk/emc/product/100435/smpc

4.Meltzer E, et al. Clinically relevant effect of a new intranasal therapy (MP29-02) in allergic rhinitis assessed by responder analysis. Int Arch Allergy Immunol. 2013; 161:369–377.

5. NHS. Hay fever. 2024. Available at: https://www.nhs.uk/conditions/hay-fever/

6. Dymista Control 137 microgram, 50 microgram nasal spray. Pharmacy Essential Guide. 2025. Available at: https://www.medicines.org.uk/emc/product/100435/rmms.

7. Dymista Control 137 microgram, 50 microgram nasal spray. PIL. 2024. Available at: https://www.medicines.org.uk/emc/files/pil.100435.pdf Online sources last accessed February 2025.

Product information and adverse event reporting

Please refer to the Summary of product characteristics (SmPC) for full information before recommending this product.

Dymista® Control 137 micrograms / 50 micrograms per Actuation Nasal Spray. Contains azelastine hydrochloride and fluticasone propionate. Indication: Relief of symptoms of moderate to severe seasonal allergic rhinitis in adults if monotherapy with either intranasal antihistamine or glucocorticoid is not considered sufficient. Dosage and method of use: 18 years of age or over: The recommended dose is one actuation in each nostril twice daily (morning and evening). The maximum daily dose should not exceed 2 sprays in each nostril per day. Dymista® Control Nasal Spray should not be used in children and adolescents under 18 years of age. Dymista® Control Nasal Spray is for nasal use only. Contra-indications: Hypersensitivity to the active substance or to any of the excipients. Warnings and Precautions: Treatment should be stopped, or the advice of a doctor sought if an improvement is not seen within 7 days. The advice of a doctor or pharmacist should also be sought if symptoms have improved but are not adequately controlled within 7 days. This medicine should not be used for more than 3 months continuously without consulting a doctor. Medical advice should be sought before using this medicine in the case of: •concomitant use of other corticosteroid products, such as tablets, creams, ointments, asthma medications, similar nasal sprays, or eye/nose drops. •fever or an infection in the nasal passages or sinuses. • recent injury or surgery to the nose, or problems with ulceration in the nose. Clinically significant drug interactions in patients receiving fluticasone propionate and ritonavir, resulting in systemic corticosteroid effects including Cushing’s syndrome and adrenal suppression. Therefore, concomitant use of fluticasone propionate and ritonavir should be avoided, unless the potential benefit to the patient outweighs the risk of systemic corticosteroid side-effects. Systemic effects of nasal corticosteroids may occur, particularly when prescribed at high doses for prolonged periods. These effects are much less likely to occur than with oral corticosteroids and may vary in individual patients and between different corticosteroid preparations. Potential systemic effects may include Cushing’s syndrome, Cushingoid features, adrenal suppression, growth retardation in children and adolescents, cataract, glaucoma and more rarely, a range of psychological or behavioural effects including psychomotor hyperactivity, sleep disorders, anxiety, depression, or aggression. Dymista® Control Nasal Spray undergoes extensive first-pass metabolism, therefore the systemic exposure of intranasal fluticasone propionate in patients with severe liver disease is likely to be increased. This may result in a higher frequency of systemic adverse events. Caution is advised in these patients. Treatment with higher than recommended doses of nasal corticosteroids may result in clinically significant adrenal suppression. If there is evidence for higher than recommended doses being used, then additional systemic corticosteroid cover should be considered during periods of stress or elective surgery. In general, the dose of intranasal fluticasone formulations should be reduced to the lowest dose at which effective control of the symptoms of rhinitis is maintained. Higher doses than the recommended one have not been tested for Dymista® Control. As with all intranasal corticosteroids, the total systemic burden of corticosteroids should be considered whenever other forms of corticosteroid treatment are prescribed concurrently. Visual disturbance may be reported with systemic and topical corticosteroid use. If a patient presents with symptoms such as blurred vision or other visual disturbances, the patient should be considered for referral to an ophthalmologist for evaluation of possible causes which may include cataract, glaucoma, or rare diseases such as central serous chorioretinopathy (CSCR) which have been reported after use of systemic and topical corticosteroids. Close monitoring is warranted in patients with a change in vision or with a history of increased ocular pressure, glaucoma and/or cataracts. If there is any reason to believe that adrenal function is impaired, care must be taken when transferring patients from systemic steroid treatment to Dymista® Control Nasal Spray. In patients who have tuberculosis, any type of untreated infection, or have had a recent surgical operation or injury to the nose or mouth, the possible benefits of the treatment with Dymista® Control Nasal Spray should be weighed against possible risk. Infections of the nasal airways should be treated with antibacterial or antimycotical therapy, but do not constitute a specific contraindication to treatment with Dymista® Control Nasal Spray. Dymista® Control Nasal Spray contains benzalkonium chloride. Long term use may cause oedema of the nasal mucosa. Side-effects: Very Common (≥1/10): Epistaxis. Common (≥1/100 and <1/10): Headache, dysgeusia (unpleasant taste), unpleasant smell. Uncommon (≥1/1,000 and <1/100): Nasal discomfort (including nasal irritation, stinging, itching), sneezing, nasal dryness, cough, dry throat, throat irritation. Rare (≥1/10,000 and <1/1000): Dry mouth. Very rare (<1/10,000): Hypersensitivity including anaphylactic reactions, angioedema (oedema of the face or tongue and skin rash), bronchospasm, dizziness, somnolence, glaucoma, increased intraocular pressure, cataract, nasal septal perforation, mucosal erosion, nausea, rash, pruritus, urticaria, fatigue, weakness. Side effects where the frequency cannot be estimated from available data: blurred vision, nasal ulcers. Systemic effects of some nasal corticosteroids may occur, particularly when administered at high doses for prolonged periods. In rare cases osteoporosis was observed if nasal glucocorticoids were administered long-term. Product licence number: PL 46302/0094 Name and address of the product licence holder: Mylan Products Ltd, Station Close, Potters Bar, Hertfordshire, EN6 1TL, United Kingdom. Supply classification: P. Cost: £13.72 (Trade price) Document number: UK-DTC-2024-00044. Date last revised: December 2024

Please continue to report suspected adverse drug reactions with any medicine or vaccine to the MHRA through the Yellow Card Scheme. It is easiest and quickest to report adverse drug reactions online via the Yellow Card website: https://yellowcard.mhra.gov.uk/ or search for MHRA. Yellow Card in the Google Play or Apple App Store. Alternatively, you can report via some clinical IT systems(EMIS/SystmOne/ Vision/MiDatabank) or by calling the Commission on Human Medicines(CHM) free phone line: 0800-731-6789. Adverse reactions/events should also be reported to MAH at e-mail address: pv.uk@viatris.com

SIMPLIFYING CONTINENCE CARE FOR YOU AND YOUR CUSTOMERS

1 in 3 women experience bladder sensitivity and incontinence1, but only 27% of them are using the right protection.

Prevalence of bladder weakness in the UK.

In the UK it is estimated that between 3 and 6 million people experience some degree of urinary incontinence1. It is a condition that affects both men and women, and is also more common with increasing age.

Urinary incontinence can happen for a number of reasons and is more common than many people realise. As many as 1 in 3 women over the age of 35 and 1 in 4 men over the age of 40 experience bladder leakage2. Additionally, many women are not currently using the right protection for their needs.

Only 27% use purpose made products specifically designed to handle bladder weakness2, as many women use period products to manage their incontinence. The result is ineffective care, and a compromised quality of life.

A very relevant and growing category for pharmacies.

Bladder Weakness has a greater importance in the Pharmacy Channel due to the high level of education, advice and guidance required by the shopper/consumer. Equipping yourself with the right tools, products and merchandising for conversations on the topic will help generate greater customer satisfaction and loyalty. This document will help you capture this growth opportunity and help support your interactions with customers on the topic of continence care.

THE PRODUCTS FAMILY CAREGIVERS REALLY VALUE

Research has shown that when it comes to continence care, shoppers prefer to go to pharmacies (where they have the option to speak to a knowledgeable expert) over and above other retailers.

72% of caregiver relatives and 65% of male and female shoppers prefer to shop in pharmacies3

Understanding how customers find the right product for their needs

In the world of pharmacy, understanding and meeting the unique needs of your customers is the cornerstone of a successful business. By utilising consumer research and sales data, you can curate your product inventory to enhance customer satisfaction and foster the growth of your pharmacy.

To begin this journey, it’s imperative to understand how consumers navigate the bladder weakness product range. Customers use the key leading brands in pharmacy as a beacon of trust and typically start their product search by identifying their preferred brand, followed by product format and then absorption level. Neilsen sales data in pharmacy also reveals that TENA dominates the bladder weakness category with an impressive 87% market share4. Always Discreet holds a 6% share of retail sales, while various smaller brands collectively constitute the remaining 7% of sales.

Delving deeper into the Bladder Weakness category, we see the majority of sales revenue, over half in fact, stems from the Pants format. This reflects a higher level of trust consumers place in healthcare professionals when dealing with more severe incontinence conditions. To be precise,

57% of incontinence sales are attributed to Pants, followed by 28% from pads, and a just 4% from Liners4. Moreover, the Men’s category shows strong potential for growth within the pharmacy sector, boasting a remarkable growth rate of over 10% year on year4.

In light of this, it is essential to mirror this consumer preference in your fixture layout, aligning products with their respective subcategories. This strategy ensures your pharmacy is well-equipped to meet the needs of your customers effectively.

57% of incontinence sales come from pants 28% of sales come from pads just 4% come from liners

ARE YOU MAXIMISING YOUR INCONTINENCE SPACE?

HOW TO DISPLAY YOUR PRODUCT RANGE TO MAXIMISE SALES

Your stock can be the most important financial asset to your business and implementing effective merchandising can deliver significant improvements to sales performance.

We want to help you provide an easy shopping layout for your customers, to ensure they can navigate your product display and find the right product for their needs.

We have created an easy-to-follow planogram that you can implement in your pharmacy, aligning product format and space to reflect their sales potential, as well as showing adjacent sub ranges for trade up opportunities. You can see this in the below example.

OUR STEP-BY-STEP GUIDE

We’ll guide you through converstions around incontinence based on our knowledge of the topic and TENA’s understanding of the different audiences who are in need of incontinence products. This conversation guide will follow four stages helping you effectively recommend TENA products to your shoppers based on their needs.

Our shoppers

Our 4 stage process

1. Identify shoppers in need of help

Reassure them that they’re not alone and there are products for their needs

Establish what lifestyle they are buying products for 4. Recommend

Men buying for themselves

Women buying for themselves

Family carers buying for their loved ones

1. Identify shoppers in need of help.

Whether shoppers are standing by the incontinence shelf, or actively approaching you for support, you can encourage a dialogue by asking a few simple questions.

Once you’ve established their answers to these initial questions, you’ll be well placed to follow either of the following guides for Men, Women or Family Carers.

“Do you need help with what you’re looking for today?”

“Incontinence can be a daunting topic for many people - if it’s helpful, I can tell you what I know and we can work out which products might be able to help… There are also leaflets on the shelf that you can read in your own time, if you’d rather”

“Are you buying the product for yourself or someone else?”

Reassure them that they’re not alone and there are products for their needs.

FAMILY CARERS

“You are not alone. 1 in 5 people globally are family carers.”

“Incontinence-related issues are very common amongst carees as well, as 1 in 3 women over 35 and 1 in 4 men over 40 suffer from bladder leakages.”

3.

Take the taboo out of incontinence and make your shoppers feel more comfortable talking to you, nuturing more loyal customers for your pharmacy.

MEN

“It’s much more common than you think – 1 in 4 men over the age of 40 experience drips and dribbles. If this is something you need support with, then there are plenty of good TENA products for you use.”

WOMEN

“You are not alone - as many as 1 in 3 women over the age of 35 have experienced bladder leaks.”

“It’s very common for women to experience bladder leaks at particular moments throughout life, such as pregnancy, post-partum and during the menopausal years.”

Establish what lifestyle they are buying products for. Before recommending the right product, it’s important to learn about the level of leaks of your shoppers, as well as when, where and what the product is needed for.

Level of leaks

Lifestyle

When do leaks occur

FAMILY CARERS, MEN, AND WOMEN

What level of leakage do they/you experience (describe the amount – a few drops, or something more)?

FAMILY CARERS

Which of their activities do they need protection for (e.g. out and about vs. at home vs. travelling) How would you describe their level of mobility? Are they dependent on others to change them?

MEN AND WOMEN

Describe a typical day for you (e.g. exercise, eating and drinking habits, bowel habits) Which of your activities do you most need protection for (e.g. out and about vs. at home vs. travelling)

FAMILY CARERS

When do their leakages generally happen? (i.e. Day or night?) Does this vary? Is it a rush to get them to the toilet in time or frequent toilet visits (day time or night time)?

MEN AND WOMEN

When do your leakages generally happen? Day or night? Does this vary? Are leaks more likely to happen where you’re exerting yourself - like when you cough, or sneeze, laugh, or do certain physical activity like lifting weights or running?

Is it a rush to get to the toilet in time or frequent toilet visits (day time or night time)?

4. Recommend.

Based on your shoppers’ needs, there are several resources that allow you to recommend the right product. TENA droplet sytemDifferent products for day and night Skin health products

KNOWLEDGE EQUALS CONFIDENCE

HERE ARE SOME ADDITIONAL TIPS TO DRIVE CUSTOMER LOYALTY

SIMPLIFYING THE SHOPPING EXPERIENCE

• Make products easy to find in the store and consider displaying products alongside other products that can benefit their situation (e.g. moisturizers or creams for improved skin health).

• Run in-store campaigns to improve product visibility and category awareness.

WIDER HEALTH TIPS RELATING TO URINE LEAKAGE

• Be observant of medical conditions that can cause urinary symptoms: diabetes, stroke, Parkinson’s disease and Multiple Sclerosis are a few examples. Always refer them to a healthcare professional to get a proper diagnosis and information on how to manage and treat the issue.

• Caffeine and alcohol reduction have a range of additional benefits, beyond helping reduce the occurrence of leaks.

• Remember to recommend drinking enough water – dehydration concentrates urine, which can promote an overactive bladder.

• Avoid drinking two hours before bedtime to help minimize night-time urination.

• Maintaining a healthy body weight and exercising regularly can help improve bladder health, as they encourage regular bowel movements, and help manage stress levels and psychological well-being.

• Some medications can also cause side effects that affect the bladder and bowel, so understanding what medication the shopper is on is also important.

WIDER SKIN HEALTH TIPS

• Keeping the skin clean prevents irritations – for sensitive skin you can use barrier creams for protection.

DOCTOR-APPROVED, FLAVOUR-INFUSED ELECTROLYTES

VEGAN & HALAL FRIENDLY

NATURAL FLAVOURS

GLUTEN & LACTOSE FREE

LOW CALORIE

TRUSTED SINCE 2012

NO ARTIFICIAL PRESERVATIVES

Formula based on the World Health Organization rehydration guidelines.

Essential electrolytes for hot weather hydration

DELICIOUSLY EFFECTIVE ELECTROLYTES

• We are the only hydration tablets that can be prescribed by Doctors in the UK

• A precise electrolyte blend to deliver fast-acting hydration

• According to EFSA, 80% of people in the UK are not adequately hydrated

SCIENTIFICALLY CRAFTED FOR OPTIMAL HYDRATION

HYDRATION CPD COURSE

From our team of medical professionals

Claim free O.R.S Hydration samples upon completion

O.R.S EVERYDAY

Hydration Range

Holiday hydration for families -down to a science

Our proven electrolyte formula

Supports healthy cognitive function

Great tasting, natural ﬂavours

Available in Blackcurrant, Strawberry and Lemon

Available in Mixed Berry and Orange

O.R.S SPORT

Electrolyte Range

The premium electrolyte choice for hot summer workouts

Fast-acting electrolyte replenishment to make up for higher sweat rates and salt loss

Contains vitamin D and Magnesium to support muscle recovery and help reduce fatigue

O.R.S IMMUNE

Electrolyte Range

The premium electrolyte choice for daily immunity

Vitamin D, Vitamin C, Zinc and iron to support immunity

Reduces tiredness & fatigue

Improves clarity & focus

Available in Juicy Orange

O.R.S KIDS

Hydration Range

Delicious electrolytes to keep kids hydrated throughout summer

Over 50 rounds of taste testing, to perfect the ﬂavour

Trusted by parents

Suitable for kids 3+

Natural sweetener

Natural strawberry ﬂavour

RECOMMEND Movicol® with confidence

Now available as P-Line AND General Sales List (GSL) options

CONSTIPATION TREATMENT IN

EUROPE1

Ensure your customers can easily find the right Movicol® in the right place

Flavour & pack size

Citrus 10 SACHETS

Flavour free 20 SACHETS

Suitability For occasional constipation

✓ Adults (18 years+)

✓ Pregnant/breastfeeding women

Citrus 20 SACHETS

Citrus 28 SACHETS

For chronic constipation and faecal impaction

✓ Adults including elderly

✓ Adolescents over 12 years

✓ Pregnant/breastfeeding women

Dose and directions

Who may benefit

•1-3 sachets daily

•Dissolve each sachet in 125ml of water

•Do not take for more than 5 days

Convenient, on-the-go pack for sporadic sufferers, new customers or when travelling

Plain option that can be mixed with a favourite cordial to suit individual taste and preference

Flavoured option ideal for home medicine cabinets so available when needed for occasional relief

Chronic constipation:

•1-3 sachets daily

•For extended use, reduce to 1 or 2 daily

•Dissolve each sachet in 125ml of water

•Do not take for more than 14 days

Pharmacist option for more regular sufferers and those with faecal impaction

Pharmacy placement

Product Information

Movicol 13.7g sachet, powder for oral solution, containing macrogol 3350 13.125g, sodium chloride 0.3507g, sodium bicarbonate 0.1785g, potassium chloride 0.0466g. Indications: Chronic constipation and faecal impaction. Legal category: P. Manufacturer: Norgine Pharmaceuticals Limited, Norgine House, Widewater Place, Moorhall Road, Harefield, Uxbridge, UB9 6NS. Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at: https://www.medicines.org.uk/emc/product/1025/smpc

Movicol Ease 13.7g sachet, powder for oral solution, containing macrogol 3350 13.125g, sodium chloride 0.3508g, sodium bicarbonate 0.1786g, Potassium chloride 0.0502g.Indications: For the relief of occasional constipation. Legal category: GSL. Manufacturer: Norgine Pharmaceuticals Limited, Norgine House, Widewater Place, Moorhall Road, Harefield, Uxbridge, UB9 6NS.Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at: https://www.medicines.org.uk/emc/product/15866/smpc

Movicol Ease Citrus Flavour 13.7g sachet, powder for oral solution, containing macrogol 3350 13.125g, sodium chloride 0.3507g, sodium bicarbonate 0.1785g, Potassium chloride 0.0466g. Indications: For the relief of occasional constipation. Legal category: GSL. Manufacturer: Norgine Pharmaceuticals Limited, Norgine House, Widewater Place, Moorhall Road, Harefield, Uxbridge, UB9 6NS. Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at:

https://www.medicines.org.uk/emc/product/15867/smpc

Adverse events should be reported. Reporting forms and information can be found at yellowcard.mhra.gov.uk. Adverse events should also be reported to Norgine Pharmaceuticals

MOVICOL, NORGINE and the sail logo are registered trademarks of the Norgine group of companies.

Job code: UK-GE-MOV-2500022

Date of preparation: April 2025

References:

1. IQIVIA Sales Data. December 2024 – data on file.

2. Movicol® Summary of Product Characteristics.

3.Attar A et al Gut 1999;44:226-230.

4. Candy D, et al. Gastroenterology. 2016;3(3).

5. Nakajima, A, et al. J Gastroenterol. 2019;54:792- 803

6. Chaussade, S, & Minić, M. Aliment Pharmacol Ther. 2003;17:165–172

7. Lee-Robichaud H, et al. Cochrane Database Syst Rev. 2010 Jul 7;(7):CD007570.

8. Wang HJ, et al. Clin Drug Investig. 2004;24(10):569-76.

9. NICE. Clinical Knowledge Summaries. Constipation. Last revised November, 2024. Accessed February, 2025. Available at: https://cks.nice.org.uk/topics/constipation/

10. Bashir A, Sizar O. Laxatives. [Updated 2024 Jan 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi. nlm.nih.gov/books/NBK537246/

11. NHS. Macrogol. Accessed February, 2025. Available at: https://www.nhs. uk/medicines/macrogol/

12. Movicol® Ease Patient Information leaflet.

13. NHS. How and when to take lactulose. Accessed February, 2025. Available at: https://www.nhs.uk/medicines/ lactulose/how-and-when-to-take-lactulose/

14. NHS. Fybogel (ispaghula husk). Last reviewed January 2022. Accessed February, 2025. Available at: https://www.nhs.uk/ medicines/fybogel-ispaghula-husk/

15. NHS. How and when to take senna. Accessed February, 2025. Available at: https://www.nhs.uk/medicines/senna/ how-and-when-to-take-senna/#:~:text=Take%20senna%20 once%20a%20day,bedtime%20so%20it%20works%20 overnight.

16. NHS. How and when to take Bisacodyl. Accessed April, 2025. Available at: https://www.nhs.uk/medicines/ bisacodyl/how-and-when-to-take-or-use-bisacodyl/ 17. NICE. Clinical Knowledge Summaries. Constipation. Last revised November, 2024. Accessed February, 2025. Available at: https://cks.nice.org.uk/topics/constipation/ 18. Common questions about Senna. NHS. Accessed February, 2025. Available at: https://www.nhs.uk/medicines/senna/ common-questions-about-senna/ 19. Bassotti, G, et al. Clin Exp Gastroenterol. 2021;14:413– 428.

WHAT are non-stimulant laxatives and when to recommend?

Essential guidance for pharmacy teams

Why Movicol® is different to other types of laxatives

How non-stimulant macrogol laxatives work

Comparing different types of laxatives

Who may benefit from Movicol® and when to recommend

Movicol® is DIFFERENT to other constipation treatments*

Movicol® is an iso-osmotic macrogol non-stimulant laxative with electrolytes which offers gentle relief of stubborn stools2

STIMULANTFREE

ISO-OSMOTIC ELECTROLYE EFFECT

Movicol® retains water in the bowel in a similar way to osmotic laxatives, but also contains added electrolytes, so there is virtually no net gain or loss of water or electrolytes3-5

NON-STIMULANT

Movicol® does not cause low or high sodium or potassium levels2

GENTLE RELIEF

Movicol® binds to water and passes through the gut virtually unchanged5

Unique triple effect Movicol® WORKS IN HARMONY with the body2,4

1: HYDRATE

Each macrogol molecule bonds with 100 water molecules to hydrate and bulk stools4

2: SOFTEN

This also softens and lubricates stools to aid a passage through the bowels2

Movicol triggers a natural and gentle bowel movement in as little as 24 hours4,6 3: RESTORE

STIMULANTFR

2 OUT OF 3 PEOPLE

HAD A BOWEL MOTION WITHIN 1 DAY OF TAKING A MACROGOL-CONTAINING PRODUCT6

Comparing Movicol®

Movicol® offers superior efficacy and tolerability to lactulose3,7 and ispaghula husk8

Comparison of OTC laxatives

ACTIVES EXAMPLES

Mode of action

Hydrates, bulks and softens stools to gently trigger a natural bowel movement2,4,6

Time to relief

Maximum duration of use

Movicol® P-line: 14 days2

Moves water into stool and softens stool9

Retains fluid in stool to increase weight and consistency10

Movicol Ease®: 5 days12 7 days13 7 days14

NICE guidance For adults

NICE guidance for adolescents (12 years +)

RECOMMENDED ADVICE

2nd-line to bulkforming laxatives9

1st-line16

Movicol® P-line: from 12+

Movicol Ease®: Not recommended for under 18 years

2nd -line alternative to macrogol isoosmotic laxative9

2nd-line17

Not mentioned17

Stimulates bowel nerves to increase motility9

Senna: 8-12 hours9

Bisocodyl: 6-12 hours9

Senna: 7 daysConsult HCP if no relief after 3 days)15

Bisocodyl: 5 days116

2nd-line17

Senna P-line: from 12+

Senna GSL: Not recommended for under 18 years

FIRST AID CATEGORY OVERVIEW

Key objective 2024: Drive engagement with Core

Plasters by far the largest segment 31% penetration unchanged for 5+ years

Segment value share 2024

POST-OPERATIVE AND LARGER WOUND TREATMENT

Painless

Our sterile larger plaster range protects from infection and is highly comfortable to wear Our larger wound plaster heroes: Sensitive & Waterproof XL/XXL

TOUCH OVERVIEW

Feel the difference. The Elastoplast plaster range.

Water Resistant

• Protects from dirt and bacteria

• Water resistant

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Fabric

• Protects from dirt and bacteria

• Extra flexible

• Water-repellent

Sensitive

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• Extra skin friendly

• Hypoallergenic

Aqua Protect

• Transparent and discreet

• 100% waterproof

• Extra strong adhesion

Extra Tough

• Waterproof and robust fabric

• Super strong adhesion

• Flexible and durable

Fast Healing

• Advanced polyurethane technology

• Up to 2x faster healing compared to dry wound healing

• Helps to reduce scarring

• Suitable for sensitive skin

Kids

• Colours are safe for children

• Easy and painless to remove

• Skin friendly

• Kids-friendly design

1 Understanding urticaria

Urticaria, also known as hives or nettle rash, is characterized by itchy, raised wheals on the skin. It can be accompanied by angioedema, which involves swelling of deeper layers of the skin.

Types & Causes:

Acute Spontaneous Urticaria: This type lasts up to six weeks and is usually easy to treat. Symptoms include redness, raised bumps, and intense itching. Severe cases may involve fever, headache, and difficulty breathing.

Chronic Spontaneous Urticaria: Symptoms can persist for more than six weeks and can last for months or even years. Often associated with angioedema.

Other types

The other types of urticaria may be due to excessive rubbing of skin, environmental factors (such as heat, cold, UV light etc), water, exercise induced or pressure.

Impact on Quality of Life:

Quality of Life (QoL) refers to the functional effects of an illness and its treatment from the patient’s perspective. In urticaria, main symptoms are itch and wheals which have a major impact on patients’ quality of life.

The main symptoms of Urticaria, itch and wheals significantly affects daily activities, sleep, work, and social interactions. It can cause emotional distress, including frustration, anxiety and embarrassment.

Please refer to back page for Histahive Essential Information.

Effectors of mast cell activation

IgG-anti-IgE

IgE-allergen

Substance P SCF DAMPs

Mast cell granulation

PAMPs CSa MBP ECP

Release of inﬂammatory mediators

TNF-a Histamine Interleukins

Fig. 1. Mast cell activation. IgG: immunoglobulin G; IgE: immunoglobulin E; SCF: stem cell factor; DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular pattern; CSa: Ciclosporin A; ECP; eosinophil cationic proteins; MBP: major basic protein; ECP: eosinophil cationic protein

Adopted from Margarita Murrieta-Aguttes et al. Fexofenadine: A review of its use in the treatment of urticaria in pediatric and adult populations. Evid Self Med 2023;3:230014 https://doi.org/10.52778/efsm.23.0014

Pathogenesis:

Urticaria is a mast cell-driven disease. Mast cells release histamine and other inflammatory mediators, causing the symptoms. Approximately 50% of chronic urticaria cases are autoimmune.

2 What is Histahive?

Ingredients:

Contains Fexofenadine hydrochloride 180 mg

Histahive dosage:

180 mg once daily before a meal

Mechanism of Action:

Fexofenadine is a non-sedating H1 antihistamine. It reduces itching and wheal formation by blocking histamine receptors

Up-Dosing of Antihistamines

If better symptom control is needed, updosing may be required1 and consumers should be directed to a doctor

Who Can Use Histahive?

Suitable for adults and children 12 years and older

3 Histahive 180mg tablet Pharmacy Checklist

Identification of hives:

Check for triggers such as certain foods, insect bites, cold, heat, stress, infections, medications, and environmental factors.

Patient profile:

Ensure patient has no allergies to Fexofenadine or to any of the excipients. Not for children under 12 or elderly without the doctor’s advice. Not recommended for pregnant or breastfeeding women without the doctor’s advice.

Comorbid conditions:

Caution in patients with heart disease, liver or kidney problems.

Concomitant medications:

Avoid interactions with antacids, antibiotics, antifungals, and other antihistamines. Take the medication as instructed, including any necessary precautions (e.g., leaving a 2-hour gap between aluminium and magnesium hydrochloride containing antacids and other medications)

4 Important information

How is Histahive different from other antihistamines?

Reduced Side Effects: Lower incidence of anticholinergic effects and sedation compared to first generation antihistamines.1

Non-drowsy in most people: Suitable for daytime use.

Extended Duration: once daily dosing provided effective symptom relief.

Selective H1 Receptor Antagonism: Fewer off-target effects.

Enhanced Quality of Life: Effective symptom control in urticaria (hives).

Good Safety Profile: Well-tolerated for up to one year of daily use.

Drug Interactions: Few drug interactions for consumers taking other medications.5

When to refer a patient to GP

The patient must be referred to a GP if:

• The symptoms do not improve after 2 days

• The rash is spreading

• Hives keeps coming back – patient may be allergic to something

• There is an elevated temperature and feel unwell

• There is swelling under the skin – this might be angioedema

What does the treatment guidelines say about antihistamines

According to urticaria guidelines, 1) Standard dose of second-generation antihistamines is the first line of treatment for all types of urticaria and 2) if better symptom control is needed, which may involve up-dosing, consumers should be directed to a doctor.1

Clinical evidence of Fexofenadine urticaria

Efficacy: The effectiveness of fexofenadine (FEX) in treating urticaria has been demonstrated in several randomized controlled trials (RCTs). It is effective in reducing pruritus and wheals and comparable to other second-generation antihistamines.

Safety: Lower frequency of adverse events and sedative effects compared to first-generation antihistamines and when compared to second-generation antihistamines, fexofenadine showed significantly fewer changes in most cognitive and psychomotor functions.

Allergic Rhinitis

An updated systematic review (2023) confirmed that the efficacy and safety profile of fexofenadine 4, a highly selective second-generation antihistamine can alleviate symptoms of allergic rhinitis. A significant reduction in total symptom scores i.e., sneezing, rhinorrhea, itchy nose/ palate, and itchy/watery/red eyes is documented

Fexofenadine is a non-sedating H1 antihistamine known for its significant efficacy and excellent safety profile in managing allergic rhinitis (AR), thereby enhancing patients’ quality of life (QoL). Its effectiveness is attributed to its high affinity for the H1 receptor.

As a second-generation non-sedating antihistamine, it is a first-line therapy for allergic rhinitis and urticaria. Randomised clinical trials have demonstrated fexofenadine as an effective treatment for allergic diseases2,3

What is the current use of fexofenadine 180mg in the UK?

Fexo 180mg is prescribed in allergic conditions such as allergic rhinitis, urticaria, atopic dermatitis and pruritus.6

Histahive SmPC

Please visit www.medicines.org.uk/emc/product/100389 for more information. www.histallay.co.uk/histahive

Product Name: Histahive 180mg Film-Coated Tablets. Active ingredient: Fexofenadine Hydrochloride. Each film-coated tablet contains 180 mg of fexofenadine hydrochloride; which is equivalent to 168 mg of fexofenadine. Product License number: PL 08553/0756. Name and address of the product licence holder: Dr. Reddy’s Laboratories (UK) Ltd. 410 Cambridge Science Park, Milton Road, Cambridge, CB40PE. Supply Classification: P Product. Indication: indicated in adults and children 12 years and older for the relief of symptoms associated with chronic idiopathic urticaria. Side Effects: The following side effects have also been reported: Common side effects (may affect up to 1 in 10 people): headache, drowsiness, feeling sick (nausea), dizziness. Uncommon side effects (may affect up to 1 in 100 people): tiredness, sleepiness.If you get any side effects talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. Refer to product SmPC for complete information Contraindications: Hypersensitivity to the active substance or to any of the excipients.You should contact your doctor immediately if you have symptoms of a serious allergic reaction such as swelling of the face, lips, tongue or throat and difficulty breathing after taking the tablets Warnings and Precautions: Talk to your doctor or pharmacist before taking Histahive if you have problems with your liver or kidneys, if you have or ever had heart problems, as fexofenadine, like other antihistamines may cause your heart to beat faster (tachycardia) or you feel your heart beating (palpitations), or if you are elderly. If any of these apply to you, or if you are not sure, tell your doctor or pharmacist before taking Histahive. Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This is especially important for the following medicines: Erythromycin (an antibiotic) Ketoconazole (a treatment for fungal infections) If you are taking apalutamide (a medicine to treat prostate cancer), as the effect of fexofenadine may be decreased. Indigestion remedies containing aluminium and magnesium may affect the action of Histahive, by lowering the amount of medicinal product absorbed. It is recommended that you leave about 2 hours between the time that you take Histahive and your indigestion remedy. If you are pregnant or breastfeeding, think you may be pregnant or planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Histahive should not be taken during pregnancy and whilst breast-feeding unless advised by a doctor. Histahive is unlikely to affect your ability to drive or operate machinery. However, you should check that these tablets do not make you feel sleepy or dizzy before driving or operating machinery. Histahive contains Allura Red AC Lake, which may cause allergic reactions. Dosage and Method of Use: The recommended dose is one tablet (180mg) daily. Take your tablet with water before a meal. Cost: RRP (ex VAT) 10 tablets pack: £4.58 30 tablets pack: £10.83. Further Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at: https://www.medicines.org.uk/emc/product/100389/smpc#about-medicine. Adverse events should be reported. Reporting forms and information can be found at yellowcard.mhra.gov.uk. Adverse events should also be reported to Pharmacovigilance at Dr Reddy’s via DrreddysGB@EU.Propharmagroup.com. Date: Essential Information is prepared on 25 November 2024 of Histahive 180mg Film-Coated Tablets Reference 1. Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al. The international EAACI/GA²LEN/EuroGuiDerm APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy. 2022;77:734–766. doi:10.1111/all.15090 2. Huang, Cz., Jiang, Zh., Wang, J. et al. Antihistamine effects and safety of fexofenadine: a systematic review and Meta-analysis of randomized controlled trials. BMC Pharmacol Toxicol 20, 72 (2019) 3. Naclerio et al.Twenty-five years: The fexofenadine clinical experience. World Allergy Organization Journal(2024) 17:100950 http://doi.org/10.1016/j.waojou.2024.100950 4. Gómez et al. Updated meta analysis on the efficacy and safety issues of fexofenadine. World Allergy Organization Journal (2023) 16:100795 http://doi.org/10.1016/j.waojou.2023.100795 5. Drug Interaction Checker, free online tool on drugs.com https://www.drugs.com/ drug-interactions/Accessed on 20.01.2025. 6. IQVIA Fexofenadine by Therapy Class MAT Q3’246

RECOMMENDATION

RECOMMEND

CHEST BURNING 1,2 SOUR TASTE 1,2

DOUBLE ACTION FOR 7 SYMPTOMS OF HEARTBURN & INDIGESTION 1,3 PROVIDES FAST ACTING AND LONG-LASTING RELIEF3,7 DOUBLE ACTION

*Associated with acid reflux.

References: 1. Heading, RC, et al. Eur J Gastroenterol Hepatol. 2016;28:455-462. 2. Heartburn and acid reflux. NHS UK. Available at: https://www.nhs.uk/conditions/heartburn-and-acid-reflux/ Accessed July 2023. 3. Gaviscon Double Action Mint Oral Suspension. Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/5609/smpc Accessed July 2023. 4. Watanabe M, et al. BMC Gastroenterol. 2017;17:92. 5. Indigestion. NHS UK. Available at: https://www.nhs.uk/conditions/indigestion/ Accessed July 2023. 6. Broderick R, et al. Dig Dis. 2020;38.188-195. 7. Dettmar, PW, et al. Drug Dev Ind Pharmacy. 2018;44:30–39.

Essential Information: GAVISCON DOUBLE ACTION ANISEED ORAL SUSPENSION: Contain per 10 ml: Sodium alginate 500 mg, sodium bicarbonate 213 mg and calcium carbonate 325 mg (GSL). Indications: Treatment of symptoms resulting from the reflux of acid, bile and pepsin into the oesophagus such as acid regurgitation, heartburn and indigestion, for example following meals or during pregnancy, and for symptoms of excess stomach acid (hyperacidity). Can also be used to treat the symptoms of gastro-oesophageal reflux during concomitant treatment with or following withdrawal of acid suppressing therapy. MAH: Reckitt Benckiser Healthcare (UK) Ltd, HU8 7DS, United Kingdom. Information about this product including adverse reactions, precautions, contraindications and method of use can be found at: www.medicines.org.uk/emc/product/685/.

GAVISCON DOUBLE ACTION MINT FLAVOUR CHEWABLE TABLETS: Each tablet contains sodium alginate 250 mg, sodium bicarbonate 106.5 mg and calcium carbonate 187.5 mg (GSL). Indications: Treatment of symptoms resulting from the reflux of acid, bile and pepsin into the oesophagus such as acid regurgitation, heartburn and indigestion, for example following meals or during pregnancy, and for symptoms of excess stomach acid (hyperacidity). Can also be used to treat the symptoms of gastro-oesophageal reflux during concomitant treatment with or following withdrawal of acid suppressing therapy. MAH: Reckitt Benckiser Healthcare (UK) Ltd, HU8 7DS, United Kingdom. Information about this product including adverse reactions, precautions, contraindications and method of use can be found at: https://www.medicines.org.uk/emc/product/5329.

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard, or search for the MHRA Yellow Card in the Google Play or Apple App Store. Adverse events should also be reported to Reckitt Benckiser Healthcare (UK) ltd on: 0333 200 5345

Summary of Terms

1. Where accounts have been approved for credit, payments are due 30 days from the month of invoice. Sigma Pharmaceuticals Plc reserves the right to charge interest on overdue accounts at the rate of 4% above the LIBOR (London InterBank Offered Rate) per month without prejudice to the right of recovery. Cheques payable to Sigma Pharmaceuticals Plc. Sigma Pharmaceuticals Plc reserves the right not to process the orders in case of an overdue account.

2. All orders and prices quoted are subject to the standard rate or reduced rate of V.A.T. on the NETT invoice value. The invoice date is the tax point for V.A.T. purposes.

3. Products on offer in the PLOF are not eligible for any further discounts.

4. All delivery enquiries must be notified within 24 hours of delivery

5. Prices are correct at time of going to print, but are subject to change without prior notice. Sigma Pharmaceuticals Plc reserves the right to amend any of their prices without due notice. Orders are accepted on condition that the goods will be invoiced at the prices ruling at the date of delivery. All images shown are for illustrative purposes only.

6. Invoice queries must be raised within one week of invoice date.

7. The goods shall remain the sole and absolute property of the seller and legal equitable owner until such time as the buyer shall have paid to the seller the agreed price together with the full price of any other contract with the seller.

8. Standard terms and conditions apply, as per trading terms, available upon request.

9. RSP’s shown are supplied by the manufacturers and are correct at time of going to print. It is at the retailers discretion to set their own retail price and margin.

Claims and Returns

DELIVERIES

When accepting your delivery please ensure the number of boxes/bulk received match the drivers runsheet and that any discrepancies are clearly marked. Non-delivery must be notified to Sigma Pharmaceuticals Plc within 1 service day of invoice date or advice of despatch.

RETURNS

Under existing rules and regulations issued by the DHSS and as published in “MAIL”, goods will only be accepted for return by Sigma Pharmaceuticals Plc for the following reasons:

• To correct an error in delivery or ordering.

• In response to a product or batch recall instigated by a manufacturer.

• Where products or packages are alleged to be faulty.

In order to be considered for credit or replacement the goods must be accompanied by a note showing:-

• The name and address of the customer returning the goods.

• The quantity and description of the goods.

• The invoice number on which the goods were supplied.

• The reason of the return.

Transfer Order Queries

Call 01923 331 411 and ask for the Transfer Order Department.

Expiry Date Queries

Dates on products should be checked upon delivery. If you wish to return an item due to the date, please follow the return procedure mentioned previously.

Items Missing From Delivery

Call 01923 444 999 within 24 hours of delivery.

Wrong Item Supplied

Mark the required item with the code of ‘B’ on your invoice/return slip.

Goods Ordered in Error

Mark the item with the code of ‘H’ on your invoice/return slip.

Goods Arrived Damaged

Mark the item with the code of ‘F’ on your invoice/return slip.

Recall Stock

All recall stock must be written on a return slip with the date, quantity and reason code K.

OTC & HEALTH AND BEAUTY TRANSFER ORDER OVERVIEW

Sigma offers a comprehensive transfer order service offering prompt deliveries, transparent invoicing and full advantage of manufacturers multi-level discounts (MLD) across a wide range of manufacturers.

WHY USE SICMA FOR TRANSFER ORDERS?

Our transparent invoice structure, quick turnaround and dedicated customer service means we are the preferred choice with manufacturers and third-party sales teams for transfer orders. Advantages of putting your transfer orders through Sigma:

> A minimum of 10% wholesaler discount on transfer orders)(-.

> Transparent discount structure

> More than 95% of products are available to order in singles

> Aim to deliver stock within 48 hours from receipt

> Back orders held for 60 days

> Dedicated transfer order team that can be directly contacted by telephone or email.

> Committed to ensure transfer order queries are resolved within 72 hours "Ethical and Rx Lines may not qualify for this discount

TRANSFER ORDER PORTFOLIO

BAYER

BIOKULT

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CLAXO SMITH l{LINE

CIGA HEALTHCARE

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BE T TERYOU

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BIOl{ULT

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BR PHARMACEU TICALS

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ETHICOE

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Cialis Together

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Dulco Range

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Opticrom

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Pharmaton

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Deep Freeze / Heat / Relief

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l{ARIUM LTD

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LASER HEALTHCARE

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· Nitty Gritty

PERRIGO (Omega Pharma)

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THE MILES GROUP

A L Simpkin

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Flexitol

Fultium

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Metanium

Movelat

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Radian B

Savlon

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Virasorb

Virasoothe

Windsetlers

Zeroderm

Tel: 0800 597 4462, Option 3

Email: cs@sigmaplc.com

Email: rushin@sigmaplc.com

Tel: 0800 597 4462, Option 3

Email: hitesh@sigmaplc.com

Sharon Walker, Customer Services Manager

Tel: 0800 358 4427

Michelle Sparrow, Business Development Manager

Email: cs@sigmaplc.com

Tel: 01923 332 790

Dipesh Vaja, Head of Sales

Tel: 0800 597 4462

Email: michelle@sigmaplc.com

The sales team supporting you at Sigma

Head of Sales

Email: dipesh@sigmaplc.com

Business Development

Sales Executives

Dipesh Vaja, Head of Sales

Tel: 0800 597 4462

Michelle Sparrow, Business Development Manager

Tel: 0800 597 4462

Tel: 01923 332 790

Email: dipesh@sigmaplc.com

Service

Pankaj Vyas - National Sales Manager

Head of Sales

Email: michelle@sigmaplc.com

Tel: 07946 352 462

Rushin Mehta, Telesales Manager

Vithal Adatia - Account Executive

Email: pankaj@sigmaplc.com

Tel: 0800 597 4462, Option 3

Dipesh Vaja, Head of Sales

Telesales/Customer Service

Dipesh Vaja, Head of Sales

Sales Executives

Tel: 0800 597 4462

Email: rushin@sigmaplc.com

Tel: 01923 331 407

Hitesh Haria, Telesales Supervisor

Email: vithal@sigmaplc.com

Tel: 0800 597 4462, Option 3

Email: hitesh@sigmaplc.com

Email: dipesh@sigmaplc.com

Rushin Mehta, Telesales Manager

Tel: 0800 597 4462, Option 3

Pankaj Vyas - National Sales Manager

Tel: 07946 352 462

Tel: 0800 597 4462, Option 3

Sharon Walker, Customer Services Manager

Email: rushin@sigmaplc.com

Tel: 0800 358 4427

Hinal Pandya, Specials Manager

Email: rushin@sigmaplc.com

Email: pankaj@sigmaplc.com

Tel: 0800 597 4475

Email: cs@sigmaplc.com

Telesales/Customer Service

Email: specials@sigmaplc.com

Hitesh Haria, Telesales Supervisor

Tel: 0800 597 4462, Option 3

Vithal Adatia - Account Executive

Tel: 0800 597 4462, Option 3

Email: hitesh@sigmaplc.com

Tel: 01923 331 407

Email: hitesh@sigmaplc.com

Email: vithal@sigmaplc.com

Sharon Walker, Customer Services Manager

Rushin Mehta, Telesales Manager

Tel: 0800 358 4427

Rushin Mehta, Telesales Manager

Sharon Walker, Customer Services Manager

Tel: 0800 358 4427

Tel: 0800 597 4462, Option 3

Business Development Team

Email: cs@sigmaplc.com

Tel: 0800 597 4462, Option 3

OTC Transfer Orders

Email: cs@sigmaplc.com

Email: rushin@sigmaplc.com

Hinal Pandya, Specials Manager

Tel: 0800 597 4475

Michelle Sparrow, Business Development Manager

Simone Elkerton OTC Transfer Orders

Tel: 01923 332 790

Business Development Team

Email: specials@sigmaplc.com

Hitesh Haria, Telesales Supervisor

Tel: 0800 597 4462, Option 3

Email: hitesh@sigmaplc.com

Lisa Farrant OTC Transfer Orders

Business Development

Tel: 01923 331 411

Email: michelle@sigmaplc.com

Sharon Walker, Customer Services Manager

Tel: 01923 331 411

Email: sim@sigmaplc.com

Tel: 0800 358 4427

Michelle Sparrow, Business Development Manager

Email: cs@sigmaplc.com

OTC Transfer Orders

Michelle Sparrow, Business Development Manager

Tel: 01923 332 790

Sales Executives

Tel: 01923 332 790

Email: michelle@sigmaplc.com

Email: lisa@sigmaplc.com

Email: michelle@sigmaplc.com

Simone Elkerton OTC Transfer Orders

Business Development

Tel: 01923 331 411

Pankaj Vyas - North London up to Midlands

Sales Executives

Tel: 07946 352 462

Email: sim@sigmaplc.com

Lizzie Harbidge Business Development Manager

Email: pankaj@sigmaplc.com

Tel: 07714 657 806

Lisa Farrant OTC Transfer Orders

Reshma Patel - North East & South London

Tel: 01923 331 411

Tel: 07767 163 171

Email: lisa@sigmaplc.com

Email: reshma@sigmaplc.com

Pankaj Vyas - North London up to Midlands

Email: lizzie.h@sigmaplc.com

Tel: 07946 352 462

Pankaj Vyas - National Sales Manager

Tel: 07946 352 462

Email: pankaj@sigmaplc.com

Sales Executives

Hinal Pandya, Specials Manager

Reshma Patel - North East & South London

Vithal Adatia - Account Executive

Tel: 07767 163 171

Tel: 0800 597 4475

Business Development

Tel: 01923 331 407

Email: reshma@sigmaplc.com

Email: vithal@sigmaplc.com

Email: specials@sigmaplc.com

Pankaj Vyas - National Sales Manager

Tel: 01923 444 999

Tel: 07946 352 462

Specials OTC Transfer Orders

Hinal Pandya, Specials Manager

Email: bd@sigmaplc.com

Specials

Hinal Pandya, Specials Manager

Email: pankaj@sigmaplc.com

Tel: 0800 597 4475

Email: pankaj@sigmaplc.com

Tel: 0800 597 4475

Email: specials@sigmaplc.com

Simone Elkerton OTC Transfer Orders

Tel: 01923 331 411

OTC Transfer Orders

Email: sim@sigmaplc.com

Hinal Pandya, Specials Manager

Tel: 0800 597 4475

Simone Elkerton OTC Transfer Orders

Vithal Adatia - Account Executive

Tel: 01923 331 407

Email: vithal@sigmaplc.com

Lisa Farrant OTC Transfer Orders

Tel: 01923 331 411

Email: lisa@sigmaplc.com

Lisa Farrant OTC Transfer Orders

Email: specials@sigmaplc.com

Tel: 01923 331 411

Simone Elkerton OTC Transfer Orders

Tel: 01923 331 411

Email: sim@sigmaplc.com

OTC Transfer Orders

Lisa Farrant OTC Transfer Orders

Tel: 01923 331 411

Email: lisa@sigmaplc.com

Simone Elkerton OTC Transfer Orders

Tel: 01923 331 411

Email: sim@sigmaplc.com

Lisa Farrant OTC Transfer Orders

Tel: 01923 331 411

Email: lisa@sigmaplc.com

Anthisan Bite and Sting 2% w/w Cream Product Information

Presentation: Cream containing 2% w/w mepyramine maleate. Indications: Symptomatic relief of skin irritation caused by insect stings, insect bites and nettle stings. Dose and administration: Route of administration: Topical. Adults, elderly and children over 2 years of age and older. Anthisan Bite and Sting Cream should be applied directly to the a ected parts two or three times a day for up to three days. Contraindications: Hypersensitivity to the active substance or to any of the excipients. Anthisan Bite and Sting Cream should not be used in eczematous conditions or on extensively broken skin surfaces, or if the skin is cut or grazed. Do not use on large areas of skin or on areas of sunburnt skin. Warnings and precautions: Repeated application of Anthisan Bite and Sting Cream to the same area for longer than three days is not recommended and treatment should be discontinued immediately if skin sensitisation occurs. Pregnancy and lactation: Anthisan Bite and Sting Cream should not be used during pregnancy or lactation, unless considered essential. Side e ects: Skin sensitisation has been reported on rare occasions. Legal category: GSL Product Licence Number: PL 35104/0038

Product licence holder: Phoenix Labs, Suite 12, Bunkilla Plaza, Bracetown Business Park, Clonee, Co. Meath, Ireland. Further information is available from Phoenix Labs, Suite 12, Bunkilla Plaza, Bracetown Business Park, Clonee, Co. Meath, Ireland. Tel +353 1 5742410, email: medicalinformation@phoenixlabs.ie. Date of preparation: January 2024

*Based on sales data. For UK contact and email veriﬁcation medicalinformation@phoenixlabs.ie

**Survey of 2,000 UK bite or sting su erers, carried out by 3GEM research on behalf of Anthisan Bite and Sting Cream (July 2018) 45% of people in the UK

Find your Natural Balance

The naturally working treatment for Bacterial Vaginosis:

Available in 2 easy to use formatspessary & gel for added convenience. +

How Balance Activ® BV Treatment Gel and Pessaries works:

Not a drug: Mimics the vagina’s own defence mechanism to treat and relieve BV.

Reliable: Clinically proven to work, for a dependable alternative.

Effective: Replenishes the body’s natural lactic acid to restore the vagina’s normal pH, rapidly relieving symptoms.

Balance: Tops up glycogen to encourage good bacteria and maintain pH balance to keep BV at bay.

Convenient: Comes with 7 single-use, gel-ﬁlled tubes –a week’s treatment – for easy and hygienic application.

Balance Activ® HerFlora Food Supplement

How Balance Activ® HerFlora works:

Mirroring the Vaginal Environment: Containing 4 billion live cultures, naturally found in the vaginal microbiome.

Enhanced energy: Say goodbye to unwanted tiredness and conquer the day with HerFlora by Balance Activ.

Hormone regulation: Each capsule helps to regulate the hormonal activity and protects cells from oxidative stress.

Normal function of immune system: Helping to maintain the normal function of the immune system, by encouraging the body to ﬁght o unhealthy bacteria.

Fertility: Working to contribute to normal fertility and maternal tissue growth.

Convenient: With each pack containing 30 capsules, these daily vitamins are compact and easy to take with you wherever you need to go.

Trusted: Balance Activ provides real solutions that women can trust to work in harmony with their bodies and embrace feminine vitality.

Balance Activ® Intimate Soothing Cream

How Balance Activ® Intimate Soothing Cream works:

Naturally e ective: Uses an anti-itch extract and calming jojoba oil to soothe and protect.

Soothing: Water based and pH balanced, its naturally soothing formula calms irritation, itching, and redness.

Moisturising: Delivers fast acting moisturisation to restore the skin in the intimate area, as well as protecting against discomfort.

Gentle: Dermatologically tested, and fragrance and paraben free.

Convenient: Applies and absorbs easily, making it ideal as a lightweight daily intimate moisturiser.

16%

Legal categories: P for Bazuka Gel and Bazuka Extra Strength Gel, and GSL for Bazuka Treatment Gel and Bazuka Extra Strength Treatment 26% w/w Gel. Indications for Bazuka Sub-Zero and Bazuka Extra Strength Treatment 26% w/w Gel: for the treatment of verrucas and warts. Bazuka Sub-Zero and Bazuka Advance Treatment Pen are Class lla Medical Devices. Further information is available from Ceuta at the above address.

BAZUKA Trademark and Product Licences are held by Diomed Developments Ltd., Hitchin, Herts, SG4 7QR, UK. Distributed by Ceuta Healthcare, Hill House, 41 Richmond Hill, Bournemouth, BH2 6HS. Indications for Bazuka Gel, Bazuka Extra Strength Gel and Bazuka Treatment Gel: for the treatment of verrucas, warts, corns and calluses.

Ltd., Hitchin, Herts, SG4 7QR, UK. Distributed by Ceuta Healthcare, Hill House, 41 Richmond Hill, Bournemouth, BH2 6HS. Indications for Bazuka Gel, Bazuka Extra Strength Gel and Bazuka Treatment Gel: for the treatment of verrucas, warts, corns and calluses. Legal categories: P for Bazuka Gel and Bazuka Extra Strength Gel, and GSL for Bazuka Treatment Gel and Bazuka Extra Strength Treatment 26% w/w Gel. Indications for Bazuka Sub-Zero and Bazuka Extra Strength Treatment 26% w/w Gel: for the treatment of verrucas and warts.

Bazuka Sub-Zero and Bazuka Advance Treatment Pen are Class lla Medical Devices. Further information is available from Ceuta at the above address.

BAZUKA

ALL THE YOU NEED RELIEF HAYFEVER

NON-DROWSY

Beconase Hayfever Relief for Adults 0.05% Nasal Spray (GSL) contains beclometasone dipropionate. For the treatment of seasonal allergic rhinitis (hayfever) in adults over 18 years. Adults aged 18 and over: 2 sprays into each nostril morning and evening (400 micrograms/day). Not recommended for use in children and adolescents under 18 years. Contraindications: Known hypersensitivity to ingredients. Caution: Concomitant use of other corticosteroid treatments, recent nasal injury or surgery, pregnancy/lactation. Side effects: Rare cases of hypersensitivity reactions, dryness/irritation of the nose and throat, raised intra-ocular pressure, nasal septal perforation. PL 02855/0065. MAH: Omega Pharma Ltd, Wrafton, Braunton, Devon, EX33 2DL, UK. Date of preparation: April 2024.

SPC: https://mhraproducts4853.blob.core.windows.net/docs/6aeba285ccfaf469c2d7b3ae86158dee77c831d6. MAT-2443

-O il ® Skincare Oil 125ml c Specialist scar and stretch markprodl.let '""' �r��\1�•�>eeol STRETCH MARKS I '"''�,��,�+·"'r�,"at' t;,��r,,d1 merka �--•1 ·g duong �SIIC'/ loo·,;s;,.,� .._, ,t·, wur.�•--= pw<,>d,;ol ' raj::l(j 'l.�1 �-- MIC � r-pr::, i� :::;:,�aro'ICeofe;ist'lQiilrt•!Y UN�N $KIN f'Qt,Jli htpeiroµ'(:,s•tt·•ap�-.c•ol un<1nr��- cor£inb:xh c,,htand n.v,-.,�,� 4(,[IJIIG&OCHYOR,lH;D:Sl(IN 1-•pss~v:ith&rd:cr•911H'l! Mid wrirli<lw �''-"''-"-' ht·�(�c;.;j'"H.; t,ooy a�:1 �tlj:sret&ll'l ·x.r,uu PUR(:ELLINOIL� C:,nt,a,mthe :)l'�_d1rc:��h�•"II Bio-Oil ® Dry Skin Gel 100ml e Bio-Oil ® Skincare Oil (Natural) 125ml P Spec altst ,c-.ar and stretch mark

Canesten® Athlete’s Foot Cream 1% w/w Cream (clotrimazole).

Indications: Treatment of tinea pedis and tinea cruris. MA Holder: Bayer plc, 400 South Oak Way, Reading, RG2 6AD (information about this product, including adverse reactions, precautions, contraindications, and method of use can be found at: https://www.medicines.org.uk/emc/product/13666/smpc). Legal Category: GSL. Date of Preparation: April 2023.

® Registered trademark of Bayer AG

TREATMENTS FOR THRUSH IN WOMEN

TOPICAL COMBI RANGE

PESSARY & EXTERNAL CREAM SOFT GEL PESSARY & EXTERNAL CREAM

Pessary

500mg clotrimazole + External cream 2% w/w clotrimazole

• A pessary to treat the internal infection.

• A double strength** external cream to calm the external symptoms of itch & discomfort.

INTERNAL & EXTERNAL CREAMS

Internal cream in pre-filled applicator 10% w/w clotrimazole + External cream 2% w/w clotrimazole

• An internal cream to treat the internal infection (may be suitable for women with vaginal dryness).

• A double strength** external cream to calm the external symptoms of itch & discomfort.

Soft gel pessary 500mg clotrimazole + External cream 2% w/w clotrimazole

• A soft gel pessary to treat the internal infection. designed to be comfortable to insert & dissolve easily.

• A double strength** external cream to calm the external symptoms of itch & discomfort.

Relief from symptoms caused by over 150 indoor & outdoor allergens*

Nasal Spray Ages 18+

Prescription Strength

Suitable for kids from 2+

Tablets

Ages 6+

*Airborne allergens such as pets, dust, pollen and mould.

Clarityn® Allergy 10mg Tablets (loratadine). Indications: Symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria. MA Holder: Bayer plc, 400 South Oak Way, Reading, RG2 6AD, UK (information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at https://www.medicines.org.uk/emc/ product/3506/smpc). Legal Category: GSL. Date of Preparation: March 2022.

Clarinaze® Allergy Control 0.05% nasal spray (mometasone furoate). Indications: Symptomatic treatment of seasonal or perennial allergic rhinitis in Adults aged ≥18 years. MA Holder: Bayer plc, 400 South Oak Way, Reading, RG2 6AD, UK. (Information about this product, including adverse reactions, precautions, contra-indications and method of use can be found at https://www.medicines.org.uk/emc/product/13697). Legal Category: P. Date of Preparation: March 2022.

Clarityn® Allergy 1mg/ml Syrup (loratadine). Indications: Symptomatic treatment of allergic rhinitis and chronic idiopathic urticaria. MA Holder: Bayer plc, 400 South Oak Way, Reading, RG2 6AD, UK (information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at https://www.medicines.org.uk/emc/ product/13696/smpc). Legal Category: GSL. Date of Preparation: March 2022

® Registered trademark of Bayer AG

Feel the clarity with Clarityn

Clarityn Allergy Syrup provides up to 24-hour allergy relief in children over the age of 2+.

and lactose-free.

Non-Drowsy in 98.8% of users

The only allergy brand containing Loratadine.

Suitable for ages 6+.

Relief for up to 24 hours and is non-drowsy in the majority of users.

Prescription strength relief, suitable for allergies including hayfever –without the need for a prescription. Available behind the counter at your pharmacy. Suitable for ages 18+.

Moderate to severe allergy sufferers may start using a few days before the allergy season.

Natural Ear Care for the Whole Family

Britain’s Number 1 Earwax Removal

About Earol®

Earol® provides effective and clinically proven results, aiding the removal of earwax, supporting ear hygiene and soothing and preventing itchy and irritated ears.

Clinically proven to soften and remove impacted earwax to prepare the ear canals for clinical dewaxing, Earol® is recommended by 93% of Ear Care Specialists** and is Britain’s Number 1 Earwax Removal Spray*.

The Earol® range consists of 5 products, used throughout your ear care journey, from looking after your little ones’ ears, to preparing for wax removal as well as providing relief from water trapping and relieving irritation after wax removal. Due to the natural properties of our range, our products are suitable for most people.

Earol® Olive Oil Spray

Clinically proven to soften ear wax, aiding wax removal and preventing future wax build up, delivered via a metered dose spray, made from a gentle blend of pharmaceutical-grade olive oil and mineral oil.

Baby Earol®

Suitable for babies aged 6 months and above, clinically proven to soften and naturally remove ear wax. Soothes itchy and irritated ears, delivered via a metered dose spray.

Earol® Aftercare Spray

Delivered via a metered dose spray, used to soothe and hydrate the skin of the ear canal after wax removal. Suitable for use on very dry skin, helping to prevent itchiness and dryness.

Clinically proven and suitable for sensitive skin, used to soften and naturally remove earwax, preventing and soothing dry and itchy ears, and used to enhance ear hygiene.

A metered dose spray containing a blend of pharmaceutical-grade olive oil and tea tree oil, to protect the ear from water trapping during water-based activities. A minimum of 6 hours protection.

Earol® Almond Oil Spray

EarolSwim®

Earol

Floradix Kindervital Fruity

Liquid Calcium and Vitamin Formula

Floradix Kindervital Fruity is a liquid calcium and vitamin formula for children, containing a delicious blend of herbs and fruit juices. Floradix Kindervital Fruity has all the benefits of the original Floradix Kindervital for Children, however it has a fruity taste, is formulated to be 100% gluten free and is suitable for vegans. Floradix Kindervital Fruity safeguards the intake of calcium, vitamins A, D, E, C, B1, niacin, B6 and B12 and is suitable for children from 3 years of age.

Recommended Daily Dose

Children 3 - 6 years: 10ml once daily

Children from 7 years and adults: 10ml twice daily

Floradix Vitamin B-Complex

Liquid Formula

Floradix Vitamin-B-Complex contains vitamins of the B-complex which are involved in a multitude of important metabolic processes in the body.

Vitamins B1, B2, B6, B12 and niacin contribute to normal energy release and to the normal function of the nervous system. Vitamins B2, B6, B12 and niacin contribute to the reduction of tiredness and fatigue. In addition vitamin B1 contributes to the normal function of the heart. Vitamins B6 and B12 contribute to normal red blood cell formation and to the normal function of the immune system. Biotin, niacin and vitamin B12 contribute to normal skin and psychological functions.

Recommended Daily Dose

Adults and children from 12 years: 20ml once daily

Children 7 - 11 years: 10ml once daily

Children 3 - 6 years: 5ml once daily

FyboCalm helps RELIEVE and PREVENT gut symptoms recurring†1-4

FyboCalm Wind & Bloating Relief

Relieves wind, bloating and abdominal pain in 2 hours, for relief up to 8 days 3

FyboCalm Diarrhoea Relief

Long-lasting relief for IBS related diarrhoea 1,2

Clinically Proven1-4

Learn More about FyboCalm's Unique Mode of Action

†Wind & Bloating and IBS type symptoms such as Constipation and Diarrhoea.

FyboCalm is a medical device. Always read the instructions.

FyboCalm Constipation Relief

Long-lasting relief for IBS related constipation 4,5

July 2024

*Associated with acid reflux. References: 1. Heading, RC, et al. Eur J Gastroenterol Hepatol. 2016;28:455-462. 2. Heartburn and acid reflux. NHS UK. Available at: https://www.nhs.uk/conditions/heartburn-and-acid-reflux/ Accessed July 2023. 3. Gaviscon Double Action Mint Oral Suspension. Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/5609/smpc Accessed July 2023. 4. Watanabe M, et al. BMC Gastroenterol. 2017;17:92. 5. Indigestion. NHS UK. Available at: https://www.nhs.uk/conditions/indigestion/ Accessed July 2023. 6. Broderick R, et al. Dig Dis. 2020;38.188-195. 7. Dettmar, PW, et al. Drug Dev Ind Pharmacy. 2018;44:30–39.

GAVISCON DOUBLE ACTION MINT FLAVOUR CHEWABLE TABLETS: Each tablet contains sodium alginate

Treatment of symptoms resulting from the reflux of acid, bile and pepsin into the oesophagus such as acid regurgitation, heartburn and indigestion, for example following meals or during pregnancy, and for symptoms of excess stomach acid (hyperacidity). Can also be used to treat the symptoms of gastro-oesophageal reflux during concomitant treatment with or following withdrawal of acid suppressing therapy. MAH: Reckitt Benckiser Healthcare (UK) Ltd, HU8 7DS, United Kingdom. Information about this product including adverse reactions, precautions, contraindications and method of use can be found at: https://www.medicines.org.uk/emc/product/5329.

RKT-M-30910 July 2023

ESSENTIAL INFORMATION:

PRODUCT INFORMATION: ellaOne® 30 mg film-coated tablet (ulipristal acetate). Refer to the SmPC for further information. INDICATION: Emergency contraception (EC) within 120 hours (5 days) of unprotected sexual intercourse or contraceptive failure. Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at: https:// mhraproducts4853. blob.core.windows.net/docs/b0731d06d3693ecfbd3c4d15547cba88d0f7de6c

MARKETING AUTHORISATION HOLDER: Laboratoire HRA Pharma, 200 avenue de Paris, 92320 Châtillon, France. MARKETED IN THE UK BY: HRA Pharma a Perrigo Company, One Embassy Gardens, Viaduct Gardens, Nine Elms, London SW11 7BW, United Kingdom LEGAL CATEGORY: P

Date of last revision of text: October 2023. Unique ID: UK/ELLA/1672

INDICATION: Hana 75 microgram film coated tablets contains desogestrel and is indicated for oral contraception in women of childbearing age to prevent pregnancy. Refer to SmPC for further product information. Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at: https://mhraproducts4853.blob.core. windows.net/docs/ f4e6d09fb70790e19085f23d5723fbe70eca96e8 MARKETING AUTHORISATION

HOLDER: Laboratoire HRA Pharma, 200 avenue de Paris, 92320 Chatillon, France. MARKETED IN THE UK BY: HRA Pharma a Perrigo Company, One Embassy Gardens, Viaduct Gardens, Nine Elms, London SW11 7BW, United Kingdom. LEGAL CATEGORY: P. Additional information and full Product Information is available on request from HRA-UK@cambreg.co.uk

Date of last revision of text: October 2023. Company Reference: UK/HANA/0582

Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard. Adverse events should also be reported to HRA Pharma on 0800 917 9548 or email HRA-UK@cambreg.co.uk

Date of preparation: December 2023. Code: UK/ELLA/1699.

Treats hives from within

• For adults and children aged 12 years and over

• Available without prescription – only in pharmacies

• Lasts 24 hours

• Acts within 1 hour

• One tablet daily

• Lactose, gluten free

• 3 years shelf life

• Available in 10’s & 30’s

Product Name: Histahive 180mg Film-Coated Tablets Active ingredient: Fexofenadine Hydrochloride. Indication: indicated in relief of symptoms with chronic urticaria. Always read the label or accompanying leaflet. Legal classification: P MA Holder: Dr Reddy’s Laboratories (UK) LTD. 410 Cambridge Science Park, Milton Road, Cambridge, CB40PE Further Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at: https://www.medicines.org.uk/emc/product/100389/smpc# about-medicine. Adverse events should be reported. Reporting forms and information can be found at yellowcard.mhra.gov.uk. Adverse events should also be reported to Pharmacovigilance at Dr Reddy’s via DrreddysGB@EU. Propharmagroup.com 2025-HHV-012 - Last revised 16.1.2025.

Apply LAMISIL ONCE to both feet

Spread evenly on toes, sole and sides of feet

Do not massage or rub Do not wash feet for 24 hours

Unique, patented ﬁlm forming technology:

Enhances Terbinaﬁne penetration by 2.5 times* 2.5 x

Days 13

Creates a reservoir that prolongs the fungicidal e ect of Terbinaﬁne for up to 13 days**

THE UK’S NO. 1 GLUCOSE SHOT*

Lift Glucose Shots, consumed all at once, contains a 15g of glucose, your body’s preferred source of energy.

Easy-to-take liquid form, to offer an immediate solution.

Fast-acting natural glucose, is caffeine, taurine, gluten and fat free. Suitable for vegans.

Convenient and pocket-friendly, it's perfect for those with diabetes - keep inyour bag or car for when needed.

Available in 4 tasty ﬂavours.

Also available in chewable tablet in tubs of 10s & 50s

These chews offer 3.7g of fast-acting glucose per tablet, so for those with diabetes. Chew three to four tablets when needed.

LoviOne® 1.5 mg Tablet (Levonorgestrel) - MA holder: NAARI B.V, Rietveldenweg 102, Netherlands

Distributor: Maxwellia Ltd. Classification: P. Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at www.lovima.com/hcp/lovione.

The 1st licensed macrogol

Over 25 years clinical use1

Movicol contains the osmotic laxative macrogol 3350 plus electrolytes

Macrogols are 1st line choice for the elderly2

A non-stimulant laxative

Can be used in pregnancy and breastfeeding†

GETTING YOU THERE ONE TRY AT A TIME.

Don’t quit trying.

*By combining NiQuitin Clear Patch and NiQuitin Minis Lozenges provides significant improvement in quit rate vs patch alone. To verify contact verify@perrigo.com

NiQuitin Clear 21 mg patches PL 02855/0237 GSL & NiQuitin Minis Mint 2mg Lozenges PL 02855/0328 GSL are used to relieve and/or prevent craving and nicotine withdrawal symptoms associated with nicotine dependence. Contains nicotine to aid nicotine withdrawal. Requires willpower. Always read the leaflet. MAH: Omega Pharma Ltd, Wrafton, Braunton, Devon, EX33 2DL, UK. Information about this product, including adverse reactions, precautions, contra-indications and method of use can be found at: https://mhraproducts4853.blob.core.windows.net/docs/f91bbc0fa449a4d253d88e66d31ec846b6ebf5fb. https://mhraproducts4853.blob.core.windows.net/docs/a2b169571b9c71e5e87745b08f054b757c50f6ef. Price is at the discretion of the retailer. MAT-6433

Relief

from Cold, Allergies, Hay Fever, Nasal & Sinus Symptoms

Over The Counter Products

(No Prescription Required) Helps Alleviate:

•Nasal Symptoms from Allergies & Hay Fever

•Nasal Symptoms from Cold & Flu

•Post Nasal Drip

•Sinus Pressure & Nasal Stufﬁness

•Allergies from Occupational and House Dust, Fumes, Animal Dander, Grass, Pollen, Smoke, etc.

•Nasal Symptoms in CPAP Users with Sleep Apnoea

•To Loosen Thick Nasal Mucous Symptoms seen in Cystic Fibrosis and Immotile Ciliary Syndrome

Contains only purified water, sodium chloride, and sodium bicarbonate; USP-graded (purity level ≥99%)

• Sterile

• Isotonic

• Non-burning

• Delivers a fine and gentle mist

• Use as often as needed

• Isotonic

• Non-burning

• Use as often as needed

• Hypertonic (2,7%)

• Reduces congestion and swelling better than isotonic spray

• Use as often as needed

NUROFEN FOR CHILDREN IS TOUGH ON TEETHING1, GENTLE ON LITTLE TUMMIES1,2

Anti-inflammatory

Up to 8 hours pain & fever relief1

Starts to work in 15 minutes to reduce fever4

3 MONTHS TO 9 YEARS STRAWBERRY 100MG/5ML 100ML

FOR CHILDREN ORAL SUSPENSION ORANGE FLAVOUR 7-12 YEARS 200MG/5ML 100ML

410-7371NUROFEN FOR CHILDREN ORAL SUSPENSION STRAWBERRY FLAVOUR 7-12 YEARS 200MG/5ML 100ML

3DIMTAP1NUROFEN FOR CHILDREN SUSPENSION WITH SYRINGE ORANGE S/F 100MG/5ML 200ML

326-7796NUROFEN FOR CHILDREN SUSPENSION WITH SYRINGE STRAWBERRY S/F 100MG/5ML 200ML

10.00%£5.00

Nuromol provides more effective pain relief than a prescription combination of paracetamol and codeine 1*

Nuromol gets to work faster than individual tablets of standard ibuprofen and paracetamol taken together 2–7 †

*Paracetamol 1000 mg + codeine 30 mg . †Based on absorption.

References: 1. Daniels SE, et al Pain. 2011;152:632–642. 2. Tanner T, et al. BMC Clin Pharmacol. 2010;10:10. 3. Wright CE, et al. Clin Pharmacol Ther. 1983;34(5):707-710. 4. Yue Y, et al. Clin Ther. 2013;35(9):1306-1320. 5. Rostami-Hodjegan A, et al. Drug Dev Ind Pharm. 2022;28(5):523-531. 6. Atkinson HC, et al. J Bioequivalence & Bioavailab. 2015;7:3. 7. Tarabar S, et al. Drugs R D. 2020;20:23-37. 8. Nuromol Pain Relief 200 mg/500 mg Film Coated Tablets. Summary of Product Characteristics. Updated June 2022. Accessed January 2023. 9. Survey of Community Pharmacists Aug-Sep 2022. 10. Mehlisch D, et al. Clin Ther. 2010;32(5):882-895. 11. Mehlisch D, et al. Clin Ther. 2010;32(6):1033-1049.

Essential Information

Nuromol Pain Relief 200 mg/500 mg film coated tablets For the temporary relief of mild to moderate pain associated with migraine, headache, backache, period pain, dental pain, rheumatic and muscular pain, pain of non-serious arthritis, cold and flu symptoms, sore throat and fever. This product is especially suitable for pain which has not been relieved by ibuprofen or paracetamol alone. Nuromol Pain Relief 200mg/500mg Film Coated Tablets is indicated in adults aged 18 years. Licence Holder: Reckitt Benckiser Healthcare (UK) Limited, Slough, SL1 3UH. Legal Classification: P. Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at https://www.medicines.org.uk/emc/product/13804.

RKT-M-09246 January 2022

Product Information

1. Lipton RB, et al. Arch Neurol 1998;55:210-7.

Product Information

Panmigrol Migraine Pain Relief 250 mg /250 mg /65 mg ﬁlm coated tablets (20s) (acetylsalicylic acid, paracetamol, ca eine).

Indications: Acute treatment of headache and of migraine attacks with or without aura. Legal category: 20s: P. Product licence holder: Haleon UK Trading Limited, The Heights, Weybridge, Surrey, KT13 0NY, U.K.

Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at: https://www.medicines.org.uk/emc/product/100454/smpc

Trade marks are owned by or licensed to Haleon group of companies. PM-GB-PAN-24-00032.

LIFE’S TOO SHORT

FOR DAILY PROTECTION AGAINST DIETARY ACIDS

Actively strengthens acid softened enamel surfaces Helps maintain high and longer-lasting levels of fluoride**

19023 PB1

Easy to use

Suitable for carrying a whole week’s medication

19039

• For cutting large pills before crushing • Suitable for those who are unable to swallow pills

Out

Useful for carrying a day’s medication • With Medication Record Card • Large volume compartments

MAX STRENGTH PARACETAMOL

*1 tablet = 1 dose (take only one tablet at a time) **Based on absorption data

SolpaOne® 1000mg Effervescent Tablets (P) contain paracetamol. For short term symptomatic treatment of mild to moderate pain and/or fever. For adults and adolescents over 50kg of body weight aged 16 years and above. 1 tablet = 1 dose (take only one tablet at a time). Do not take more than 4 tablets (4000mg) per day. Do not use for more than 3 days unless on medical advice. Maximum paracetamol strength in 1 tablet. MAH: Cipla (EU) Limited Dixcart House, Addlestone Road, Bourne Business Park, Addlestone, Surrey, KT15 2LE, UK. Information about this product, including adverse reactions, precautions, contraindications, and method of use can be found at: https://mhraproducts4853.blob.core.windows.net/docs/0fa5f0aaeab6197db9e35e4f460b88b21e36e654

PRODUCTS NOW AVAILABLE

6 DAY EARLY PREGNANCY

High sensitivity Midstream pregnancy test which can detect hCG in the urine as early as 6 days prior to the expected period date.

BLOOD PRESSURE MONITOR

Simple user-friendly blood pressure monitor which can store blood pressure readings for two users. Also includes irregular heartbeat detection. Product includes batteries and one year warranty.

TWIN MIDSTREAM PREGNANCY

Rapid Midstream pregnancy test delivers results in 1-3 minutes which can detect hCG in the urine as early as 4 days prior to the expected period date.

DIABETES SCREENING

A rapid, convenient and cost-effective method for the indirect measurement of blood sugar levels to assist in the diagnosis and management of diabetes. Contains three test strips.

TWIN STRIP PREGNANCY

Can be carried out by collecting urine and ‘dipping’ the test in the sample, over 99% accurate.

HEALTH CHECK-UP

A rapid, ten parameter, low-cost solution to evaluate a number of conditions affecting kidney, liver and heart etc. Six dipstick tests included.

URINARY TRACT INFECTION TEST

Urinary tract infections (UTIs) are common infections which affect the urinary tract, including the bladder (cystitis) urethra (urethritis) or kidneys (kidney infection). Suresign urinary tract infection test strips can aid in the detection of elevated levels of Leukocytes or Nitrites in urine, indicating inflammation or potential bacterial infection in the patient. Contains three dipstick tests.

UP TO 12 HOURS DRYNESS

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TENA discreet pads effectively lock in moisture to keep you dry for up to 12 hours offering your customers superior protection day or night.

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DISCREET PROTECTION DESIGNED FOR MEN

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TENA Men offers superior protection against light leaks and dribble up to large urine leaks and surges. Available in different shapes, sizes and absorbency levels so you can find the best product for your customers needs.

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Feminine and discreet pant, for total protection and management of moderate to heavy bladder leaks. Made 30% thinner than previous TENA Silhouette, for comfort, style and maximum discretion, without compromise on protection.

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TENA Pants protect+ Super TENA Pants protect+ Night Plus

TENA Pants Protect+ is designed for both men and women experiencing moderate to very heavy bladder and/or bowel incontinence. With a highly absorbent core that quickly and effectively locks in liquid, TENA Pants provide your customers with total security.

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For dry mouth –when just water is not enough

1 in 5 suffer from dry mouth, and water is usually the standard remedy. But for many people, water only provides brief relief.

TePe’s new hydrating mouthwash and mouth gel ease the feeling of dry mouth, provides comfort, and protects teeth. We recommend the gentle, unflavoured products for those with a very dry mouth and mildly flavoured products for those with moderate problems.

TePe® Hydrating Mouthwash

TePe’s mouthwash moistens the mucosa and leaves a pleasant feeling in the mouth. Not only does it help with dry mouth, but the added 0.2 % fluoride also gives that extra protection against caries.

TePe® Hydrating Mouth Gel

TePe mouth gel gives immediate and long-lasting comfort*, moistens and soothes the oral mucosa and is convenient and easy to use whenever you need it – great for on-the-go.

TePe® Hydrating Spray

A saliva stimulating spray that offers refreshment for people who experience dry mouth. It immediately stimulates saliva and provides a moisturised, refreshed feeling. The spray contains xylitol and fluoride to help protect against cavities. The TePe Hydrating Mouth Spray has a mild apple/peppermint flavour, is easy to use on-the-go, whenever freshness is needed.

*The duration of the comfort is individual; people with no or very little saliva usually experience a more

FEXOFENADINE:

Treathay 120 mg film-coated tablets (GSL) contains fexofenadine hydrochloride. For the relief of symptoms associated with seasonal allergic rhinitis, in adults and children aged 12 and over. Adults and children 12 years and over: 1 tablet once daily taken before a meal. Not recommended for use in children under 12 years. Contraindications: Known hypersensitivity to ingredients. Caution: elderly and renally or hepatically impaired, history of or ongoing cardiovascular disease. Pregnancy and breast-feeding: avoid in pregnancy and do not use during breast-feeding unless on the advice of a doctor. Side effects: headache, drowsiness, dizziness, nausea, fatigue, hypersensitivity reactions with manifestations such as angioedema, chest tightness, dyspnoea, flushing and systemic anaphylaxis, insomnia, nervousness, sleep disorders or nightmares/excessive dreaming (paroniria), tachycardia, palpitations, diarrhoea, rash, urticaria, pruritus. PL 16028/0190 MAH: Galpharm Healthcare Ltd., Wrafton, Braunton, EX33 2DL, United Kingdom. RRP (ex. VAT): 19g £3.33. Date of preparation: 11/2023. RRP (ex. VAT): 19g £3.33. SPC: https://mhraproducts4853.blob.core.windows.net/docs/710d70496dfabc80f887d8ab58929f73826a596b. *to verify contact verify@perrigo.com.**hayfever relief. MAT-7049