E45 Cream is clinically proven to treat dry skin conditions such as: of the UK population will experience a skin condition each year*
RED FLAGS
The following headaches should be referred urgently to A&E/999:6
Those associated with a recent HEAD INJURY
Those that come on suddenly and are EXTREMELY PAINFUL
Extremely painful headaches with additional symptoms such as affected vision, the white part of the EYE IS RED, DROWSINESS/CONFUSION, any signs of meningitis or problems speaking.
TACKLING HEADACHE
IN THE PHARMACY
Headaches have a variety of causes and may be classified as primary (e.g. tension, migraine or cluster) or secondary (there is an underlying cause).1
Symptoms and triggers may be used to help you to identify the type of headache a customer has.
COUNTER CONSULTATION
Brought to you by
ABOUT HEADACHES
● A tension-type headache is the most common type, and the one that customers may think of as a normal everyday headache.2 May be described as a constant ache affecting both sides of the head.
● Migraine headaches are moderate to severe in nature, with throbbing on one side of the head.3
● Cluster headaches are rare, more common in men and tend to start at around 30-40 years of age.4 They begin quickly and the pain is severe on one side of the head, usually around the eye.
● Medication overuse headaches can occur in customers who take triptans or combination painkillers on 10 days per month or more, or who take pain relief such as paracetamol or ibuprofen on 15 days per month or more.5
● Customers with cluster headaches or suspected medication overuse headaches should be referred to their GP.
MAKING RECOMMENDATIONS
There are two typical situations where customers may ask pharmacists for information about headache solutions:
● On their first purchase.
● When their headache turns from mild to moderate.
In both cases, your expert advice and guidance is crucial.
DID YOU KNOW?
It is estimated that the UK population loses 25 million days from work or school each year because of migraine.7
TENSION HEADACHE OR MIGRAINE?
Below are some key differences between the two types of headache to help your consultations:*
Location of pain as described
Type of pain as described
Associated symptoms
Duration
Triggers
Aggravated by physical activity?
Base of the skull and upper part of the neck. Pain is the same on both sides.2,8
Dull, like a band around the head not. aggravated by physical activity.2,8
No specific associated symptoms.5 Muscles in the back of the neck and head can feel tender to touch.8,9
Usually 30 minutes to several hours, but can be days.2
Include: stress, poor posture, tiredness, Triggers certain smells, dehydration and noise.2
Usually on one side of the head.3
Severe, pulsating, pounding or throbbing 8
Nausea, vomiting and/or phonophobia and photophobia.3
Several hours to three days.3
Include: stress, tiredness, menstruation and certain food/drink.3
Not aggravated by routine physical activity.5 Yes.3
OTC OPTIONS
Customers with tension headache may be recommended:
● Paracetamol
● Aspirin
● Non-steroidal anti-inflammatory drugs (NSAIDs)
Combination products can be used if the above alone are not enough to relieve the customer’s pain. They may include additional pain relief agents such as codeine. Codeine can cause addiction and drowsiness.
Painkillers are most effective if taken at the first sign of a migraine attack.3 OTC options for migraines include:
● Paracetamol
● Aspirin
● NSAIDs
● Combination products
● Triptans
As with tension headache, combination products can be used if single analgesics do not offer sufficient pain relief. Some products also contain buclizine for nausea. Customers should be advised to only use painkillers on a short-term basis. If they need to use them for longer, they should speak to their GP.
TENSION HEADACHE MIGRAINE
TREATING TENSION HEADACHE AND MIGRAINE
WITH SYNDOL TABLETS
SYNDOL TABLETS contain:
● Paracetamol (450mg) helps block the nerves that transmit the pain impulse to the brain.10
● Codeine (10mg) helps reduce the brain’s awareness of these pain impulses.10
● Caffeine (30mg) can enhance the effects of paracetamol.11
● Doxylamine succinate (5mg) a first-generation antihistamine.
Syndol Tablets provide short-term relief of acute moderate pain which is not relieved by paracetamol, aspirin or ibuprofen alone, such as:
Tension headache and migraine.
Muscle pain, including in the face, head and neck.
Other types of pain that Syndol can help relieve include neuralgia, toothache, dysmenorrhoea, muscular and rheumatic aches and pains and post-operative analgesia following surgical or dental procedures.
COUNSELLING CUSTOMERS
Important information to share with customers purchasing Syndol Tablets:
● Suitable for adults and children aged over 12 years. See product packaging for full dosage information.
● Can cause addiction and should be taken for a maximum of three days only.
● If no effective pain relief is achieved within three days, the customers/carers should be advised to see their GP.
● Advise customers that Syndol may affect their ability to drive or use machinery, so they should ensure they are not affected before undertaking these activities. They should carefully read the patient information leaflet for more information.
● Customers should avoid alcohol while taking Syndol Tablets.2
ADDITIONAL ADVICE
for customers affected by a tension headache includes:12
Get enough, but not too much, sleep
Don’t smoke
Eat regularly (but limit sugar)
Have plenty of water and limit alcohol and caffeine
Exercise regularly
References: 1: https://www.bmj.com/content/330/7487/346 2: https://www.nhs.uk/conditions/tension-headaches/ 3: https://www.nhs.uk/conditions/migraine/ 4: https://www.nhs.uk/conditions/cluster-headaches/ 5: https://www.nice.org.uk/guidance/cg150 6: https://www.nhs.uk/conditions/headaches/ 7: Steiner et al. The prevalence and disability burden of adult migraine in England and their relationships to age, gender and ethnicity. 2003. 8: Alison Blenkinsopp: Symptoms in the Pharmacy 5th Edition. Blackwell Publishing 9: https://patient.info/brain-nerves/headache-leaflet/tension-headache 10: Syndol SmPC 11: Iqbal N et al. The effect of caffeine on the pharmacokinetics of acetaminophen in man. Biopharm Drug Dispos. 1995 Aug;16(6):481-7 12: https://www.mayoclinic.org/diseases-conditions/tension-headache/symptoms-causes/syc-20353977
All online references accessed February 2024.
Syndol Film-coated Tablets Product Information
Presentation: Film-coated tablets containing paracetamol 450mg, codeine phosphate 10mg, doxylamine succinate 5mg and caffeine 30mg. Indications: For the short term treatment of acute moderate pain which is not relieved by paracetamol, Ibuprofen or aspirin alone such as headache, tension headache, migraine, neuralgia, toothache, dysmenorrhoea, muscular and rhematic aches and pains and post-operative analgesia following surgical or dental procedures. Codeine is indicated in patients older than 12 years of age for the treatment of acute moderate pain which is not considered to be relieved by other analgesics such as paracetamol or ibuprofen (alone). Dosage and administration: The duration of treatment should be limited to 3 days, do not take continuously for more than 3 days without consulting your doctor. Adults: One or two tablets every four to six hours up to a maximum of 8 tablets in 24 hours. Elderly and debilitated: Codeine should be used with caution in the elderly and debilitated patients as they may be more susceptible to the respiratory depressant effects. Children 16 to 18 years: One to two tablets every 6 hours up to a maximum of 8 tablets in 24 hours. Children 12 to 15 years: One tablet every 6 hours up to a maximum of 4 tablets in 24 hours. Codeine should not be used in children below the age of 12 years. Contraindications: Hypersensitivity to paracetamol, codeine or other opioid analgesics, doxylamine succinate, caffeine or any of the other constituents. Concomitant use with monoamine inhibitors (MAOIs) or within 14 days of stopping treatment with these medicines. Conditions where morphine and opioids are contraindicated. All paediatric patients (0-18 years) who undergo tonsillectomy and/or adenoidectomy for obstructive sleep apnoea syndrome due to an increased risk of developing serious and life-threatening adverse reactions. Patients who are CYP2D6 ultra-rapid metabolisers or CYP2D6 deficient. Severe hepatocellular insufficiency. Warnings and precautions: Not recommended in use in children under 12 years of age. Not recommended in children 12 to 18 years of age with risk factors that may increase their sensitivity to the respiratory depressant effects of codeine. Do not take concurrently with any other paracetamol or codeine containing medicines. Codeine consumed in higher doses and over a longer prolonged period may cause addition. Administration must be discontinued gradually after prolonged treatment. There have been reports of drug abuse with codeine. Caution is particularly recommended for use in children, adolescents, young adults and in patients with a history of drug and/or alcohol abuse. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. E110 and E104 may cause allergic reaction. Concomitant use with alcohol is not recommended. Concomitant prescribing of sedative medicines with opiods should be reserved for patients for whom alternative treatment options are not possible. Excessive intake of caffeine should be avoided while taking this medicine. Co-administration of enzyme-inducing antiepileptic medications may increase toxicity. Care is advised in patients with impaired kidney or liver function and in those with hypertension, hypotension, hyperthyroidism, adrenocortical insufficiency, prostatic hypertrophy, multiple sclerosis, urinary retention, susceptibility to angle-closure glaucoma, shock, obstructive bowel disorders, acute abdominal conditions, recent gastrointestinal surgery, gallbladder conditions (including patients that have had their gall bladder removed), diseases that present with reduced respiratory capacity, myasthenia gravis, a history of cardiac arrhythmias or convulsions, low glutathione reserves, Gilbert’s syndrome, Glucose-6-phosphate-dehydrogenase deficiency, anxiety disorders, and in patients with a history of emotional instability. A risk-benefit assessment should be performed in the case of opoid dependence, conditions with elevated intracranial pressure and head trauma, impaired consciousness and compromised respiratory function. Hepatotoxicity may occur with paracetamol even at therapeutic doses, after short treatment duration and in patients without pre-existing liver dysfunction. Patients should be advised of the signs and symptoms of Stevens-Johnson syndrome (SNS) and Toxic epidermal necrolysis TEN) and monitored closely for skin reactions. Codeine may induce faecal impaction, producing incontinence, spurious diarrhoea, abdominal pain and rarely colonic obstruction. Elderly people may be more sensitive to the effects of this product. Monitoring after prolonged use should include blood count, liver and renal function. Caution is advised in patients with underlying sensitivity to aspirin and/or non-steroidal anti-inflammatory drugs (NSAIDS). Extensive use of analgesics to relieve headaches or migraine may induce headaches. Interactions: Syndol may enhance the sedative effects of CNS depressants such as alcohol, barbiturates, anaesthetics, hypnotics, other opioid analgesics, anxiolytic sedatives, antipsychotics, tricyclic antidepressants and phenothiazines, resulting in increased CNS depression. It may also have an additive antimuscarinic action with other drugs, such as atropine and some antidepressants. Consult your doctor or pharmacist if you are taking or have recently taken: medicines used to thin the blood, metoclopramide or domperidone, chelating resins, cholestyramine, mexiletine, kaolin or loperamide, naloxone, buprenorphine, naltrexone, cimetidine, cisapride, quinidine, theophylline, antibiotics, the oral contraceptive pill, cinacalcet, methadone, rifampin, phenytoin, antivitamin K. Pregnancy and lactation: Use during pregnancy and lactation should be avoided. Side effects: Doxylamine succinate: Common: drowsiness, paradoxical stimulation, headaches, psychomotor impairment, urinary retention, dry mouth, blurred vision, gastrointestinal disturbances, thickened respiratory tract secretions. Rare: hypotension, extrapyramidal effects, dizziness, confusion, depression, sleep disturbances, tremor, convulsions, palpitation, arrhythmia hypersensitivity reactions, blood disorders and liver dysfunction. Paracetamol: Very rare: thrombocytopenia, serious skin reactions, neutropenia, leukopenia, erythema, uriticaria, rash. Not known: agranulocytosis, haemolytic anaemia, anaphylactic shock, angioedema, toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome (SJS), acute generalized exanthematous pustulosis, fixed drug eruption, cytolytic hepatitis, bronchospasm. Hypersensitivity including skin rash may occur. Codeine: constipation, drowsiness, nausea, vomiting, sweating, facial flushing, dry mouth, blurred or double vision, dizziness, orthostatic hypotension, malaise, tiredness, headache, anorexia, vertigo, bradycardia, palpitations, respiratory depression, dyspnoea, allergic reactions and difficulties in micturition. Rarely: convulsions, hallucinations, nightmares, uncontrolled muscle movements, muscle rigidity, mental depression and stomach cramps. Very rare: pancreatitis. Not known: hypersensitivity, confusional state, dysphoriam, euphoria, seizure, headache, somnolence, dizziness, sedation, miosis, visuomotor coordination and visual acuity, tinnitus, pruritus, urinary retention, hypotension. Regular prolonged use of codeine is known to lead to addiction and symptoms of restlessness and irritability may result when treatment is stopped. Prolonged use of a painkiller for headaches can make them worse. Caffeine: Not known: anxiety, insomnia, restlessness, tremor, gastric disorders, heart rate increased. RRP (ex VAT): 10 tablets £3.67. Legal category: P. Product licence number: PL35104/0049. MA holder: Phoenix Labs, Suite 12, Bunkilla Plaza, Bracetown Business Park, Clonee, Co. Meath, Ireland. Further information is available from: Phoenix Labs. Tel +3531 5742410, email: medicalinformation@phoenixlabs.ie. Date of preparation: December 2024.
Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard Adverse events should also be reported to medicalinformation@phoenixlabs.ie
Presentation:Syndol Film-coated tablets containing paracetamol 450mg, codeine phosphate 10mg, doxylamine succinate 5mg and caffeine 30mg. Indications: For the short term treatment of acute moderate pain which is not relieved by paracetamol, ibuprofen or aspirin alone such as headache, tension headache, migraine, neuralgia, toothache, dysmenorrhea, muscular and rheumatic aches and pains and post operative analgesia following surgical or dental procedures. MA holder: Phoenix Labs, Suite 12, Bunkilla Plaza, Bracetown Business Park, Clonee, Co. Meath, Ireland. email: medicalinformation@phoenixlabs.ie. Tel: +353 1 5742410. Legal classification: P. Information about this product including adverse reactions, precautions, contraindications and method of use can be found at: https://mhraproducts4853.blob.core.windows.net/docs/8ac3fdf78dec28bdab8e3890f2582e1a1f4cc8e6Corresponding
Date of preparation December 2024
Retail Category Management
QUICK GUIDE TO ADVISING ON
Feel confident incorporating the latest treatment for erectile dysfunction (ED) into your consultations
AVARANTE® (tadalafil 10mg) is a new* product licensed to treat ED.
AVARANTE joins VIAGRA CONNECT to expand the Viatris range of pharmacyonly medicines licensed for ED in adult men (aged 18 years and over).1,2
*New from the makers of VIAGRA CONNECT
This training is not intended to replace the AVARANTE Risk Minimisation Materials (RMMs). You can access all the RMMs via the link provided on page 3.
Tadalafil and sildenafil belong to the same drug class, namely phosphodiesterase type 5 (PDE5) inhibitors.1,2 Oral PDE5 inhibitors are regarded as the first-line drug treatment for ED in men who don’t have specific contraindications to their use.3,4
There are no significant differences in the efficacy, safety or tolerability of different PDE5 inhibitors.4 However, slight variations do exist and therefore, in specific circumstances, one product could be considered a more suitable choice than the other.
CONSIDERATIONS WHEN CHOOSING TREATMENT
The choice of PDE5 inhibitor mostly depends on the frequency of intercourse and the customer’s preference.5
The table below gives a pharmacokinetic comparison of tadalafil1 and sildenafil,2 that may be useful in your decision-making process.
Recommended time taken before sexual activity
Time to reach maximum plasma concentration
Time to onset of effect
Duration of action
to 36 hours Up to 4 hours
Rate of absorption reduced by mean of 60 minutes when taken with food, especially a
Tadalafil Sildenafil
Tadalafil
Sildenafil
Other specific considerations may include:
l
Onset of action
VIAGRA CONNECT can start to work in as little as 25 minutes.2 AVARANTE can lead to erections for successful intercourse in 30 minutes.1 Customers who favour fast onset of action may benefit from using VIAGRA CONNECT as no pill works faster for ED.2
l
Duration of action
VIAGRA CONNECT is effective up to 4 hours after administration.2 AVARANTE can work for up to 36 hours after taking it.1 Customers may benefit from AVARANTE’s longer window of opportunity on special occasions, such as a romantic getaway.
l
Frequency of use
AVARANTE is not recommended for continuous daily use. Those who use it frequently (i.e. at least twice weekly) should discuss with their GP whether a low daily dose of tadalafil on prescription would be more suitable.1 VIAGRA CONNECT is suitable for daily use, if required.2
l Food intake
Tadalafil’s rate of absorption is not affected by food, whereas sildenafil’s rate of absorption may be reduced/delayed by a mean of 60 minutes when taken with food, especially a high-fat meal.2
l Efficacy
Most men will achieve an erection the first or second time they use a PDE5 inhibitor. However, they should be advised that it may need to be taken a number of times on different occasions before they can achieve an erection satisfactory for sexual activity. In the case of tadalafil, this should be no more than one tablet per day and no more than twice a week.1 Two metaanalyses suggest that customers who prioritise high efficacy should use sildenafil 50mg (e.g. VIAGRA CONNECT).5
l Tolerability and side effects
PDE5 inhibitors are generally well tolerated. The side effect profiles are slightly different. Tadalafil has been associated with a lower occurrence of flushing6 and visual symptoms7 compared with sildenafil,2 but possibly a higher incidence of back and muscle pain.1,2,3,6
Customers who are concerned about specific side effects may wish to bear this in mind. Two meta-analyses demonstrate that customers who are concerned about side effects should start with tadalafil 10mg (e.g. AVARANTE).5
SUPPLYING AVARANTE
ED may be referred to as erection problems (EPs) by your customers. Always ensure that you are clear on what they mean, regardless of the terminology they use, before supplying a product.
There are set criteria that must be met before an initial supply of AVARANTE can be made. The pharmacy checklist contains specific questions to check your customer’s suitability in relation to their:8
l Cardiovascular health
l Medication and recreational drug use
l Other health conditions.
When a customer requests a repeat supply, you should determine whether AVARANTE remains suitable for them by checking that:8,9
l They have not experienced any problems relating to AVARANTE
l There are no changes in their health conditions or other medications since the last supply.
Refer to the Pharmacy Guide for AVARANTE 10mg film-coated tablets (tadalafil) and AVARANTE (tadalafil) Pharmacist Checklist Quick Guide for full details. If it is not appropriate to supply AVARANTE, refer the customer to their GP. When supply is deemed appropriate, discuss the key points below with your customer.
Key advice:1,8,9
l The recommended dose is one 10mg tablet taken with or without food, at least 30 minutes prior to anticipated sexual activity
l The maximum dosing frequency is once per day; AVARANTE is not recommended for continuous daily use. Men who use this product frequently (i.e. at least twice a week) should be referred to their GP to discuss the suitability of a once-daily regimen with a lower dose, or consider an alternative treatment option
l Sexual stimulation is required for AVARANTE to work and its effects can last for up to 36 hours
l Do not take AVARANTE with grapefruit juice (this may increase the plasma levels of tadalafil)
l Do not take AVARANTE after excessive alcohol consumption
l AVARANTE works for most men on the first or second attempt, but if it does not work after several attempts, or if their ED worsens, they should be referred to their GP
l Must avoid nitrates, nitric oxide donors, amyl nitrite and nitrous oxide
l Common side effects include headache, back pain, muscle aches, pain in arms and legs, facial flushing, nasal congestion and dyspepsia
l Seek medical attention immediately if serious side effects occur
l Advise men to inform their doctor that they have started taking AVARANTE, especially if they are prescribed any new medication.
Please refer to the SmPC and Pharmacy Guide for AVARANTE 10mg film-coated tablets (tadalafil) for full details relating to contraindications, special warnings and precautions for use, interactions and side effects. Always advise your customer to read the Patient Information Leaflet and remember to refer anyone asking for treatment for EPs to their GP for a clinical review within six months,1 regardless of whether OTC treatment has been supplied or not. Appropriate lifestyle advice should also be offered.8,9
Customer choice
The concomitant use of AVARANTE and other treatment for ED, including PDE5 inhibitors, is not recommended. A customer may switch from one oral PDE5 inhibitor to another, or from a prescription-only product to an OTC option.
Always ensure that they continue to meet the relevant criteria before supplying AVARANTE8 or VIAGRA CONNECT.10 Advise them to read the relevant Patient Information Leaflet and encourage them to inform their doctor that they are obtaining treatment for their EPs from the pharmacy.
l Customers switching from a prescription of tadalafil 10mg to AVARANTE should wait at least 36 hours after their last prescription dose before starting AVARANTE.9
l Customers switching from sildenafil 50mg on prescription, or from an OTC sildenafil 50mg product, should be advised to follow the correct dosing instructions.9
There may be instances when a customer could benefit from temporarily switching from one product to the other. For example, a customer using VIAGRA CONNECT as their usual go-to treatment may switch to AVARANTE when they plan a romantic weekend away.
NOTE: they should never be taken together at the same time, or on the same day.
The customer will need to wait at least 36 hours after their last AVARANTE dose before taking VIAGRA CONNECT on the next occasion. Customers taking VIAGRA CONNECT should wait 24 hours after their last dose before taking AVARANTE.
To find out more about AVARANTE and complete your training, visit https://www.medicines.org.uk/emc/product/100210/rmms#about-medicine
References:
1. AVARANTE 10mg film-coated tablets. SmPC. 2024. Available at: https://www.medicines.org.uk/emc/product/100210/smpc/print. 2. Viagra Connect 50 mg film-coated tablets. SmPC. 2024. Available at: https://www.medicines.org.uk/emc/product/8725 3. BNF. Erectile dysfunction. 2024. Available at: https:// bnf.nice.org.uk/treatment-summaries/erectile-dysfunction/ 4. Hatzimouratidis K, et al. Pharmacotherapy for erectile dysfunction: recommendations from the Fourth International Consultation for Sexual Medicine (ICSM 2015). J Sex Med. 2016; 13(4):465-488. 5. Salonia A, et al. EAU Guidelines on sexual and reproductive health. 2024. Available at: https://d56bochluxqnz.cloudfront.net/documents/full-guideline/EAU-Guidelines-on-Sexual-and-ReproductiveHealth-2024 2024-05-23-101205 nmbi.pdf 6. Gong B, et al. Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta analysis. Int Urol Nephrol. 2017; 49:1731–1740. 7. Ahmed NS. Tadalafil: 15 years’ journey in male erectile dysfunction and beyond. Drug Dev Res. 2019; 80:683–701. 8. AVARANTE 10mg film-coated tablets (tadalafil) Pharmacist Checklist Quick Guide. 2024. Available at: https://www.medicines.org.uk/ emc/rmm/101578/Document. 9. Pharmacy Guide for AVARANTE 10mg film coated tablets (tadalafil). 2024. Available at: https://www.medicines.org.uk/emc/ rmm/101574/Document. 10. Essential information for the supply of VIAGRA CONNECT 50 mg film-coated tablets (sildenafil). 2023. Available at: https://www. medicines.org.uk/emc/rmm/1784/Document. Online references last accessed December 2024
Avarante 10mg tablets Product Information
Presentation: Avarante 10mg tablets. Contains tadalafil Indication: Erectile dysfunction in adult men. Dose and Administration: Men (including the elderly) 18 years of age or over: The recommended dose is one 10mg tablet taken at least 30 minutes prior to anticipated sexual activity. The maximum dosing frequency is once per day. Avarante is not recommended for continuous daily use. Contraindications: Hypersensitivity to the active substance or to any of the excipients, co-administration with nitric oxide donors or nitrates, cardiac disease in patients where sexual activity is inadvisable, myocardial infarction within the last 90 days, unstable angina or angina during sexual intercourse, heart failure within 6 months, uncontrolled arrhythmia, hypotension (<90/50 mm Hg), uncontrolled hypertension, stroke within 6 months, non-arteritic anterior ischaemic optic neuropathy causing loss of vision in one eye, co-administration with guanylate cyclase simulators (e.g. riociguat), deformation of the penis (such as angulation, cavernosal fibrosis or Peyronie’s disease), women, those without erectile dysfunction and men under 18 years of age. Warnings and Precautions: All men with erectile dysfunction should be advised to consult their doctor within 6 months for a clinical review of potential underlying conditions and risk factors associated with erectile dysfunction. If symptoms of erectile dysfunction have not improved after taking Avarante on several consecutive occasions or if their erectile dysfunction worsens patients should consult their doctor. Patients who experience erections lasting longer than 4 hours should seek immediate medical assistance. Patients should consult their doctor before taking Avarante if they have: undergone pelvic surgery or radical non-nerve sparing prostatectomy, known hereditary degenerative retinal disorders (e.g. retinitis pigmentosa), had coronary artery bypass surgery or angioplasty, asymptomatic controlled hypertension, mild valvular disease, severe renal impairment, severe hepatic insufficiency, previous diagnosis of uncontrolled hypertension, moderate to severe valvular disease, left ventricular dysfunction, hypertrophic obstructive cardiomyopathies or significant arrhythmia, increased susceptibility to vasodilators including those with left ventricular outflow obstructions (e.g. aortic stenosis) or those with the rare syndrome of multiple atrophy, sickle cell anaemia, multiple myeloma or leukaemia. Patients with cardiovascular disease should be advised that sexual activity carries a cardiac risk and if they experience chest pain during sexual activity they should refrain from any further sexual activity and seek medical attention immediately. Avarante is not recommended for patients who experience chest pain or breathlessness after light or moderate activity. Avarante contains lactose; patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take Avarante. Avarante is not recommended to be taken concurrently with recreational drugs. Interactions: Nitrates, nitric oxide donors (nicorandil, molsidomine), doxazosin and other alpha 1 adrenergic blockers, antihypertensives, riociguat, 5-alpha reductase inhibitors (e.g. finasteride), theophylline, ethinylestradiol, terbutaline, alcohol, CYP3A4 inhibitors such as ketoconazole, itraconazole, erythromycin, clarithromycin, and grapefruit juice should be administered with caution as they may increase the incidence of adverse reactions. Inducers of CYP3A4 such as rifampicin, phenobarbital, phenytoin and carbamazepine may decrease plasma concentrations of tadalafil and decrease efficacy. Pregnancy and breastfeeding: Avarante is not indicated for use in women. Side Effects: Adverse events observed from spontaneous reporting and clinical trials: Common (≥1/100 and <1/10): Headache, flushing, nasal congestion, dyspepsia, back pain, myalgia, pain in extremity. Uncommon (≥1/1,000 and <1/100): Hypersensitivity reactions, dizziness, blurred vision, eye pain, tinnitus, tachycardia, palpitations, hypotension, hypertension, dyspnoea, epistaxis, abdominal pain, vomiting, nausea, gastro-oesophageal reflux, rash, haematuria, prolonged erections, chest pain, peripheral oedema, fatigue. Rare (≥1/10,000 and <1/1000): Angioedema, stroke (including haemorrhagic events), syncope, transient ischaemic attacks, migraine, seizures, transient amnesia, visual field defect, swelling of eyelids, conjunctival hyperaemia, non-arteritic anterior ischemic optic neuropathy, retinal vascular occlusion, sudden hearing loss, myocardial infarction, unstable angina pectoris, ventricular arrhythmia, urticaria, Stevens-Johnson syndrome, exfoliative dermatitis, hyperhydrosis, priapism, penile haemorrhage, haematospermia, facial oedema, sudden cardiac death. RRP: 2 pack £11.99, 4 pack £21.99, 8 pack £37.99. Supply classification: P Product licence number: PLGB 46302/0243. Product licence holder: Mylan Products Ltd, Station Close, Potters Bar, Herts, EN6 1TL, UK. Document number: UK-AVT-2024-00028. Date of preparation: November 2024.
Name of product: VIAGRA CONNECT® 50 mg Film-coated Tablets Active ingredient: Sildenafil
Product licence number: PL 50622/0063
Name and address of the product licence holder: Upjohn UK Limited, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK Supply classification: P Indications: For erectile dysfunction in adult men. Side Effects: The safety profile of VIAGRA is based on > 9,000 patients in > 70 double-blind placebo controlled clinical studies. The most commonly reported adverse reactions in clinical studies among sildenafil treated patients were headache, flushing, dyspepsia, nasal congestion, dizziness, nausea, hot flush, visual disturbance, cyanopsia and vision blurred. Adverse reactions from post marketing surveillance has been gathered covering an estimated period >10 years. Because not all adverse reactions are reported to the Marketing Authorisation Holder and included in the safety database, the frequencies of these reactions cannot be reliably determined. Very Common (≥ 1/10): Headache. Common (≥ 1/100 and <1/10): Dizziness, Visual colour distortions (Chloropsia, Chromatopsia, Cyanopsia, Erythropsia and Xanthopsia), Visual disturbance, Vision blurred, Flushing, Hot flush, Nasal congestion, Nausea, Dyspepsia. Uncommon (≥ 1/1,000 and <1/100): Rhinitis, Hypersensitivity; Somnolence; Hypoaesthesia, Lacrimation disorders (Dry eye, Lacrimal disorder and Lacrimation increased), Eye pain, Photophobia, Photopsia, Ocular hyperaemia, Visual brightness, Conjunctivitis, Vertigo, Tinnitus, Tachycardia, Palpitations, Hypertension, Hypotension, Epistaxis, Sinus congestion, Gastro Oesophagael reflux disease, Vomiting, Abdominal pain upper, Dry mouth, Rash, Myalgia, Pain in extremity, Haematuria, Chest pain, Fatigue, Feeling hot, Heart rate increased. Rare (≥ 1/10,000 and <1/1,000): Cerebrovascular accident, Transient ischaemic attack, Seizure, Seizure recurrence, Syncope, Non-arteritic anterior ischaemic optic neuropathy (NAION), Retinal vascular occlusion, Retinal haemorrhage, Arteriosclerotic retinopathy, Retinal disorder, Glaucoma, Visual field defect, Diplopia, Visual acuity reduced, Myopia, Asthenopia, Vitreous floaters, Iris disorder, Mydriasis, Halo vision, Eye oedema, Eye swelling, Eye disorder, Conjunctival hyperaemia, Eye irritation, Abnormal sensation in eye, Eyelid oedema, Scleral discoloration, Deafness, Sudden cardiac death, Myocardial infarction, Ventricular arrhythmia, Atrial fibrillation, Unstable angina, Throat tightness, Nasal oedema, Nasal dryness, Hypoaesthesia oral, Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN),Penile haemorrhage, Priapism, Haematospermia, Erection increased, Irritability Precautions: Erectile dysfunction can be associated with a number of contributing conditions, e.g. hypertension, diabetes mellitus, hypercholesterolaemia or cardiovascular disease. As a result, all men with erectile dysfunction should be advised to consult their doctor within 6 months for a clinical review of potential underlying conditions and risk factors associated with erectile dysfunction (ED). If symptoms of ED have not improved after taking VIAGRA CONNECT on several consecutive occasions, or if their erectile dysfunction worsens, the patient should be advised to consult their doctor. Cardiovascular risk factors: Since there is a degree of cardiac risk associated with sexual activity, the cardiovascular status of men should be considered prior to initiation of therapy. Agents for the treatment of erectile dysfunction, including sildenafil, are not recommended to be used by those men who with light or moderate physical activity, such as walking briskly for 20 minutes or climbing 2 flights of stairs, feel very breathless or experience chest pain. The following patients are considered at low cardiovascular risk from sexual activity: patients who have been successfully revascularised (e.g. via coronary artery bypass grafting, stenting, or angioplasty), patients with asymptomatic controlled hypertension, and those with mild valvular disease. These patients may be suitable for treatment but should consult a doctor before resuming sexual activity. Patients previously diagnosed with the following must be advised to consult with their doctor before resuming sexual activity: uncontrolled hypertension, moderate to severe valvular disease, left ventricular dysfunction, hypertrophic obstructive and other cardiomyopathies, or significant arrhythmias. Sildenafil has vasodilator properties, resulting in mild and transient decreases in blood pressure. Patients with increased susceptibility to vasodilators include those with left ventricular outflow obstruction (e.g., aortic stenosis), or those with the rare syndrome of multiple system atrophy manifesting as severely impaired autonomic control of blood pressure. Men with these conditions must not use the product without consulting a doctor. Sildenafil potentiates the hypotensive effect of nitrates (see Contra-indications). Serious cardiovascular events, including myocardial infarction, unstable angina, sudden cardiac death, ventricular arrhythmia, cerebrovascular haemorrhage, transient ischaemic attack, hypertension and hypotension have been reported post-marketing in temporal association with the use of sildenafil. Most, but not all, of these patients had pre-existing cardiovascular risk factors. Many events were reported to occur during or shortly after sexual intercourse and a few were reported to occur shortly after the use of sildenafil without sexual activity. It is not possible to determine whether these events are related directly to these factors or to other factors. Priapism: Patients who have conditions which may predispose them to priapism (such as sickle cell anaemia, multiple myeloma or leukaemia), should consult a doctor before using agents for the treatment of erectile dysfunction, including sildenafil. Prolonged erections and priapism have been occasionally reported with sildenafil in post-marketing experience. In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. If priapism is not treated immediately, penile tissue damage and permanent loss of potency could result. Concomitant use with other treatments for erectile dysfunction: The safety and efficacy of combinations of sildenafil with other treatments for erectile dysfunction have not been studied. Therefore the use of such combinations is not recommended. Effects on vision: Cases of visual defects have been reported spontaneously in connection with the intake of sildenafil and other PDE5 inhibitors (see Side Effects). Cases of non-arteritic anterior ischaemic optic neuropathy, a rare condition, have been reported spontaneously and in an observational study in connection with the intake of sildenafil and other PDE5 inhibitors (see Side Effects). Patients should be advised that in the event of any sudden visual defect, they should stop taking VIAGRA CONNECT and consult a physician immediately (see Contra-indications). Concomitant use with CYP3A4 inhibitors: Pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors (such as ketoconazole, itraconazole, erythromycin, cimetidine). Although, no increased incidence of adverse events was observed in these patients, they should be advised to consult a doctor before taking VIAGRA CONNECT as a 25 mg tablet may be more suitable for them (see Precautions). Concomitant use with alpha-blockers: Caution is advised when sildenafil is administered to patients taking an alpha-blocker, as the co-administration may lead to symptomatic hypotension in a few susceptible individuals (see Precautions). This is most likely to occur within 4 hours post sildenafil dosing. In order to minimise the potential for developing postural hypotension, patients should be hemodynamically stable on alpha-blocker therapy prior to initiating sildenafil treatment. Thus, patients taking alpha blockers should be advised to consult their doctor before taking VIAGRA CONNECT as a 25 mg tablet may be more suitable for them. Treatment should be stopped if symptoms of postural hypotension occur, and patients should seek advice from their doctor on what to do. Effect on bleeding: Studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside in vitro. There is no safety information on the administration of sildenafil to patients with bleeding disorders or active peptic ulceration. Therefore the use of sildenafil is not recommended in those patients with history of bleeding disorders or active peptic ulceration, and should only be administered after consultation with a doctor. Hepatic impairment: Patients with hepatic impairment must be advised to consult their doctor before taking VIAGRA CONNECT, since a 25 mg tablet may be more suitable for them (see Dosage and Method of use). Renal impairment: Patients with severe renal impairment (creatinine clearance <30 mL/min), must be advised to consult their doctor before taking VIAGRA CONNECT, since a 25 mg tablet may be more suitable for them (see Dosage and Method of use). Lactose: The film coating of the tablet contains lactose. VIAGRA CONNECT should not be administered to men with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. Sodium: This medicinal product contains less than 1 mmol sodium (23 mg) per tablet. Patients on low sodium diets can be informed that this medicinal product is essentially ‘sodium-free’. Use with alcohol Drinking excessive alcohol can temporarily reduce a man’s ability to get an erection. Men should be advised not to drink large amounts of alcohol before sexual activity. Contra-indications: Hypersensitivity to the active substance or to any of the excipients listed in section 6.1. Consistent with its known effects on the nitric oxide/cyclic guanosine monophosphate (cGMP) pathway, sildenafil was shown to potentiate the hypotensive effects of nitrates, and its co-administration with nitric oxide donors (such as amyl nitrite) or nitrates in any form is therefore contraindicated. Co-administration of VIAGRA CONNECT with ritonavir (a highly potent P450 enzyme inhibitor) is contraindicated (see Precautions). The co-administration of phosphodiesterase type 5 (PDE5) inhibitors, including sildenafil, with guanylate cyclase stimulators, such as riociguat, is contraindicated as it may potentially lead to symptomatic hypotension (see Precautions). Agents for the treatment of erectile dysfunction, including sildenafil, should not be used by those men for whom sexual activity may be inadvisable, and these patients should be referred to their doctor. This includes patients with severe cardiovascular disorders such as a recent (6 months) acute myocardial infarction (AMI) or stroke, unstable angina or severe cardiac failure. Sildenafil should not be used in patients with severe hepatic impairment, hypotension (blood pressure < 90/50 mmHg) and known hereditary degenerative retinal disorders such as retinitis pigmentosa (a minority of these patients have genetic disorders of retinal phosphodiesterases). This is because the safety of sildenafil has not been studied in these sub-groups of patients, and its use is therefore contraindicated. Sildenafil is contraindicated in patients who have loss of vision in one eye because of non-arteritic anterior ischaemic optic neuropathy (NAION), regardless of whether this episode was in connection or not with previous PDE5 inhibitor exposure. VIAGRA CONNECT should not be used in patients with anatomical deformation of the penis (such as angulation, cavernosal fibrosis or Peyronie’s disease). VIAGRA CONNECT is not indicated for use by women. The product is not intended for men without erectile dysfunction. This product is not intended for men under 18 years of age. Dosage and Method of use: For Oral Use: Adults: The recommended dose is one 50 mg tablet taken with water approximately one hour before sexual activity. The maximum recommended dosing frequency is once per day. If VIAGRA CONNECT is taken with food, the onset of activity may be delayed compared to the fasted state. Patients should be advised that they may need to take VIAGRA CONNECT a number of times on different occasions (a maximum of one 50 mg tablet per day), before they can achieve a penile erection satisfactory for sexual activity. If after several attempts on different dosing occasions patients are still not able to achieve a penile erection sufficient for satisfactory sexual activity, they should be advised to consult a doctor. Elderly: Dosage adjustments are not required in elderly patients (≥ 65 years old). Renal Impairment: No dosage adjustments are required for patients with mild to moderate renal impairment. However, since sildenafil clearance is reduced in individuals with severe renal impairment (creatinine clearance <30ml/min), individuals previously diagnosed with severe renal impairment must be advised to consult their doctor before taking VIAGRA CONNECT, since a 25 mg tablet may be more suitable for them (see Precautions). Hepatic Impairment: Sildenafil clearance is reduced in individuals with hepatic impairment (e.g. cirrhosis). Individuals previously diagnosed with mild to moderate hepatic impairment must be advised to consult their doctor before taking VIAGRA CONNECT, since a 25 mg tablet may be more suitable for them (see Precautions). The safety of sildenafil has not been studied in patients with severe hepatic impairment, and its use is therefore contraindicated (see Contra-indications). Paediatric population: VIAGRA CONNECT is not indicated for individuals below 18 years of age. Use in patients taking other medicinal products: Pharmacokinetic analysis of clinical trial data indicated a reduction in sildenafil clearance when co-administered with CYP3A4 inhibitors (such as ritonavir, ketoconazole, itraconazole, erythromycin, cimetidine). With the exception of ritonavir, for which co-administration with sildenafil is contraindicated (see Contra-indications), individuals receiving concomitant treatment with CYP3A4 inhibitors must be advised to consult their doctor before taking VIAGRA CONNECT, since a 25 mg tablet may be more suitable for them (see Precautions). In order to minimise the potential of developing postural hypotension in patients receiving alpha blocker treatment (e.g. alfuzosin, doxazosin or tamsulosin), patients should be stabilised on alpha blocker therapy prior to initiating sildenafil treatment. Thus, patients taking alpha blockers must be advised to consult their doctor before taking VIAGRA CONNECT since a 25 mg tablet may be more suitable for them (see Precautions). Addition of a single dose of sildenafil to sacubitril/valsartan at steady state in patients with hypertension was associated with a significantly greater blood pressure reduction compared to administration of sacubitril/valsartan alone. Therefore, caution should be exercised when sildenafil is initiated in patients treated with sacubitril/valsartan. C+D Trade Price (exc VAT): 2 pack £8.82, 4 pack £16.17 and 8 pack £28.39 Date of revision: 04/2023
Please continue to report suspected adverse drug reactions with any medicine or vaccine to the MHRA through the Yellow Card Scheme. It is easiest and quickest to report adverse drug reactions online via the Yellow Card Website: https://yellowcard.mhra.gov.uk/ or search for MHRA Yellow Card in the Google Play or Apple App Store. Alternatively, you can report via some clinical IT systems (EMIS/SystmOne/Vision/MiDatabank) or by calling the Commission on Human Medicines (CHM), free phone line: 0800–731–6789. Adverse reactions/events should also be reported to MAH at e-mail address: pv.uk@viatris.com.
The SmPC for this product, including adverse reactions, precautions, contra-indications, and method of use can be found at: http://www.mhra.gov.uk/Safetyinformation/Medicinesinformation/ SPCandPILs/index.htm and from Viatris Medical Information, Building 4, Trident Place, Hatfield Business Park, Mosquito Way, Hatfield, Hertfordshire, AL10 9UL, phone no. 01707 853000 Email: info.uk@viatris.com
Thrush Cream
3 out of 4 women will experience thrush at some point in their life.1
Within Womens Intimate health thrush treatment is worth 60.6M and holds 54% share of the women's intimate health category
How Balance Activ® Thrush Cream works:
Not a drug: 3 benefits in 1 treatment to help the body fight the cause, treat the symptoms, and prevent thrush.
Protects: Restricts the growth of harmful bacteria, allowing the body to fight the cause.
Relieves: Provides relief from intimate itching, redness, and soreness.
Prevents: Retores and maintains a balanced vaginal pH and flora to prevent thrush from recurring.
Simple: No fragrance and paraben added.
Convenient: Includes 5 single-use applicators for easy insertion. Can also be used externally.
Balance Activ BV Treatment
The UK’s #1 BV Treatment*
Clinically proven to treat and relieve Bacterial Vaginosis and restore women's natural vaginal pH.
How Balance Activ® BV Treatment Gel and Pessaries works:
Not a drug: Mimics the vagina’s own defence mechanism to treat and relieve BV.
Reliable: Clinically proven to work, for a dependable alternative.
Effective: Replenishes the body’s natural lactic acid to restore the vagina’s normal pH, rapidly relieving symptoms.
Balance: Tops up glycogen to encourage good bacteria and maintain pH balance to keep BV at bay.
Convenient: Choose from 7 single-use gel-filled tubes or 7 individually wrapped pessaries for easy, hygienic application.
*Source: Nielsen IQ Total Retail Women’s Health Unit Sale and Amazon Unit Sales w/e 19th Nov 2024
What is Bacterial Vaginosis?
Vaginas are naturally acidic, but if pH levels rise over 4.5, it can cause Bacterial Vaginosis (BV) with its unexpected discharge and unusual odours. BV is very common, completely natural and is easily relieved with clinically proven Balance Activ® BV Treatment Gel.
In the UK, 1 in 3 women of childbearing age will get BV in their lifetime1 BV is one of the most common vaginal conditions17
17. NHS inform. Bacterial Vaginosis. Accessed June 2019. https://www.nhsinform.scot/illnesses-and-conditions/sexual-and-reproductive/bacterial-vaginosis
The pH of the vagina should be between 3.5-4.5, the same as a tomato16,18
16. Hay P.E, Brogden, K. and Guthmiller, J. (2002). Polymicrobial diseases. Washington, D.C.: ASM Press,Chapter 7: Bacterial Vaginosis as a mixed infection. 18. Whfoods. The worlds healthiest foods. Accessed June 2019. http://whfoods.org/genpage.php?tname=dailytip&dbid=383
Self-misdiagnosis is common, with 66% of women mistaking BV symptoms for thrush19
19. NHS inform. Bacterial Vaginosis. Accessed June 2019. https://www.nhsinform.scot/illnesses-and-conditions/sexual-and-reproductive/bacterial-vaginosis
Up to 72% of women will su er from BV again within 7 months.19 BV is not caused by poor hygiene
19. NHS inform. Bacterial Vaginosis. Accessed June 2019. https://www.nhsinform.scot/illnesses-and-conditions/sexual-and-reproductive/bacterial-vaginosis
Is not an STI
Can still occur even if a woman has never had sexual intercourse
Can only be treated with the right diagnosis.
Tell the difference between BV and Thrush
Symptom
Pain or burning when urinating
Vaginal discharge
Discharge odour
Local symptoms
Other symptoms
Check out Balance Activ's free symptom checker to help with diagnosis.
BV
Pain during urination or sex, redness, and swelling are not typical.
Discharge is thin, watery and grey. There may be a larger amount than normal.
Strong fishy odour, especially after sex.
Bacterial vaginosis does not usually cause any soreness or itching.
Thrush
Discharge is white, thick and curd-like.
Discharge is odourless.
Itching or soreness around the vagina.
Pain during sex.
Intimate Daily Foam Wash
Refresh and soothe the intimate area with Balance Activ Intimate Daily Foam Wash. This lightweight foam matches and helps maintain the pH of delicate vulval skin, which helps promote good vaginal health.
How Balance Activ® Intimate Daily Foam Wash works:
Tailored: A formula designed to work in harmony with your body.
pH-balanced: Matches the natural pH of the delicate vulval skin to promote good vaginal health.
Soothing: A refreshing and soothing e ect that relieves discomfort and redness.
Skin-friendly: Gynaecologist and dermatologist tested for intimate skin, and mild enough for daily use.
Simple: Dispense 2-3 pumps of foam and softly massage into the Intimate area1. Rinse thoroughly with clean, warm water to maintain your natural pH and feel immediate freshness.
Balance Activ® Soothing Cream
Enriched with anti-itch extract
avenanthramide, skin calming
jojoba oil and moisturising
vitamin E, Balance Active Intimate
Soothing Cream soothes and protects the external intimate skin.
How Balance Activ® Intimate Soothing Cream works:
Naturally e ective: Uses an anti-itch extract and calming jojoba oil to soothe and protect
Soothing: Water based and pH balanced, its naturally soothing formula calms irritation, itching, and redness.
Moisturising: Delivers fast acting moisturisation to restore the skin in the intimate area, as well as protecting against discomfort.
Gentle: Dermatologically tested, and fragrance and paraben free
Convenient: Applies and absorbs easily, making it ideal as a lightweight daily intimate moisturiser.
Balance Activ® HerFlora Food Supplement
From maintaining the normal function of your immune system to empowering your body’s defence against unwelcome
How Balance Activ® HerFlora works:
Mirroring the Vaginal Environment: Containing 4 billion live cultures, naturally found in the vaginal microbiome.
Enhanced energy: Say goodbye to unwanted tiredness and conquer the day with HerFlora by Balance Activ.
Hormone regulation: Each capsule helps to regulate the hormonal activity and protects cells from oxidative stress.
Normal function of immune system: Helping to maintain the normal function of the immune system, by encouraging the body to fight o unhealthy bacteria.
Fertility: Working to contribute to normal fertility and maternal tissue growth.
Convenient: With each pack containing 30 capsules, these daily vitamins are compact and easy to take with you wherever you need to go.
Trusted: Balance Activ provides real solutions that women can trust to work in harmony with their bodies and embrace feminine vitality.
Living with Allergies
Did you know?
Allergic rhinitis affects between 10% and 30% of all adults and as many as 40% of children.1 For many allergy sufferers living with the symptoms of their allergies can have a serious affect on their quality of life with the most common reported symptoms being2 :
Allergy is the most common chronic disease in Europe with up to 20% of allergy patients suffering from severe allergies3
Puffy lids Fatigue
Itchy, watery and burning eyes
Blocked nose
Runny nose & sneezing
With such a broad symptomology it can sometimes be difficult for patients to get relief from all of these debilitating issues. Many allergy patients report being dissatisfied with prescribed treatments, complaining about incomplete symptom relief. Often allergy sufferers will go for over-the-counter first generation antihistamines which can sometimes have unwanted side-effects.4
The first step in controlling allergies is allergen avoidance - trying to prevent exposure to allergens. This can be difficult with many allergy sufferers affected by more than one allergen. The most common environmental allergen - pollen - may be seasonal, but it is extremely difficult to avoid.
Other allergens like mould, animal dander and in particular house dust mite waste are perennial and as such very difficult to escape.
Finding a better way
With allergy avoidance not always an option and the first port of call being antihistamines, which can cause sedation and impairment, many allergy sufferers end up switching medications regularly in an effort to find effective relief.
There is now a definite change in patient attitudes, with a desire for more natural solutions, and not just in the allergy market. Many healthcare providers are seeing natural, non drug treatments performing well. But the key to success is efficacy, natural products must be comparable to their pharmacological equivalents to be successful.
Did you know?
The global market for complementary and alternative medicine products is forecast to grow at 18.2% until 2024.5
Introducing a natural alternative
Scope have introduced a brand new natural, drug free approach to effective allergy symptom relief. This range targets the various allergy symptoms with a variety of products including:
• FUSION™ Allergy Nasal Spray
• FUSION™ Allergy Eye Drops
• FUSION™ Allergy Eye Spray
• FUSION™ Allergy Cooling Mask
This range specifically targets the most common allergy symptoms, effectively, and without causing side-effects.6 side-effects.
What makes FUSION™ Allergy different?
Ectoin®* is a key ingredient in the FUSION™ Allergy range, a naturally occurring molecule produced by micro-organisms that flourish in harsh and dry environments such as salt lakes and deserts.
Ectoin® has been shown to be a well tolerated, safe, molecule with anti-inflammatory and anti-allergic properties.4,7 Ectoin® builds a natural water-rich shield on mucus membranes found in the nasal cavity, the lining of the mouth and throat and on the ocular surface to protect cells from allergens.4 With less allergens reaching the mast cells, this reduces histamine release. Less histamine results in reduced symptoms. In addition because FUSION™ Allergy is a preservative free range, it means an irritation free option for your patients.
Ectoin® is a safe, effective, and side-effect free, treatment option for allergy symptoms. 4
How does FUSION™ Allergy benefi t your patients?
The FUSION™ Allergy range offers your allergy patients a new and innovative option to treat and prevent their everyday symptoms:
• A natural, complete, drug-free option to manage allergies
• Proven relief from inflammation, itching and tearing4
• Preservative free and natural meaning irritation free
• Effective OTC alternative with comparable treatment to prescribed allergy medicines with virtually no side effects at all 6,7
1 Pawankar, R., Holgate, S. T., Canonica, G. W., Lockley, R. F., & Blaiss, M. S. (2013). World Allergy Organization (WAO) White Book on Allergy: Update 2013. In World Allergy Organization. (Leonardi et al., 2015
3. EAACI. (2015). Global Atlas of Allergic Rhinitis and Chronic Rhinosinusitis. In European Academy of Allergy and Clinical Immunology.
4. Werkhäuser, N., Bilstein, A., & Sonnemann, U. (2014). Treatment of Allergic Rhinitis with Ectoine Containing Nasal Spray and Eye Drops in Comparison with Azelastine Containing Nasal Spray and Eye Drops or with Cromoglycic Acid Containing Nasal Spray. Journal of Allergy, 2014, 1–13.
6. Salapatek, A., Bates, M., Bilstein, A., & Patel, D. (2011). Ectoin®, a Novel, Non-Drug, Extremophile-Based Device, Relieves Allergic Rhinoconjunctivitis Symptoms in Patients in an Environmental Exposure Chamber Model. Journal of Allergy and Clinical Immunology, 127(2), AB202–AB202.
7 Allegri, P., Marrazzo, G., Ciurlo, C., Mastromarino, A., Autuori, S., & Murialdo, U. (2014). Retrospective study to evaluate the efficacy on vernal kerato-conjunctivitis (VKC) of 2% Ectoine versus 0.05% ketotifen eye-drops. Investigative Ophthalmology and Visual Science, 55(13), 2492.
FUSION™ Allergy Nasal Spray
The complete range for the treatment & prevention of allergy symptoms
Presentation Composition
20ml Nasal spray Ectoin®, Sea Salt and Water
All ages The treatment and prevention of allergic Rhinitis symptoms.
FUSION™ Allergy Eye Spray 10ml Eye spray Ectoin®, Water, Vitamin A, Vitamin E
All ages The treatment of the symptoms of allergic conjunctivitis including care of dry, irritated & inflamed eyelids
FUSION™ Allergy
15 Single Dose Units x 0.5ml Ectoin®, Sodium Chloride, Water, and Citrate Buffer
1 year plus The treatment and prevention of allergic conjunctivitis symptoms.
Adults and Children The treatment of the symptoms of allergic conjunctivitis including care of dry, irritated & inflamed eyelids.
Otrivine Extra Dual Relief
0.5mg/ml + 0.6mg/ml Nasal Spray, solution
Xylometazoline hydrochloride, ipratropium bromide
Works up to 6x faster than decongestant tablets.†11
Symptomatic treatment of nasal congestion and rhinorrhea in connection with common colds.
Only product to contain a combination of xylometazoline hydrochloride and ipratropium bromide.
Otrivine Sinusitis Relief
0.1% w/v Nasal Spray, solution
hydrochloride
Otrivine Congestion Relief
0.1% Nasal Spray
hydrochloride
Works up to 6x faster than decongestant tablets.† 11 Helps unblock in 2 minutes and helps patients breathe better* for up to 10 hours.
Comfortable congestion relie f 1 – with patented mist** technology.††
Symptomatic relief of nasal congestion, perennial and allergic rhinitis (including hay fever), sinusitis.
Relieves nasal congestion and sinusitis
Contains cooling aromatic vapours of menthol to provide a pleasant cooling sensation.
Recommend Otrivine for nasal congestion
*Vs. placebo, in case of nasal congestion.
**Nozzle provides fine mist.
† Vs. pseudoephedrine and phenylephrine pills.
†† EP2654967B1.
References:
1. Khone Usability Testing Consumer Research: Quantitative, Qualitative and Neuroscientific V2 Jan 2019. 2. Common Cold: How common is it? NICE CKS. Available from https://cks.nice.org.uk/topics/common-cold/background-information/prevalence/. 3. Smith AP & Jamson S. BMJ Open 2012;2:e001047. 4. Bramley TJ et al. J Occup Environ Med 2002;44:822–29. 5. Rombaux P et al. Rhinology 2005;43:242–50. 6. Graf P et al. Expert Opin Pharmacother 2009;10:889–908. 7. Lunn M & Craig T. Sleep Med Rev 2011;15(5):293–99. 8. Ipsos. Respiratory Health Landscape 5 Markets (Germany, Poland, Italy, Russia, and India). HALEON. 2023. 9. Khone Hand Dexterity Qualitative Report. Haleon. November 2022. 10. Haleon Data on File, QD-RPT-058247. 11. Eccles R. In: Eccles R, Weber O (eds). 2009.
Product Information:
Please refer to the Summary of Product Characteristics for full product information. Otrivine Sinusitis Relief, 0.1% w/v Nasal Spray, Solution, Otrivine Congestion Relief 0.1% Nasal Spray (xylometazoline hydrochloride). Indications: Symptomatic relief of nasal congestion, perennial and allergic rhinitis (including hay fever), sinusitis. Legal category: GSL. Licence holder: Haleon UK Trading Limited, The Heights, Weybridge, Surrey, KT13 0NY, UK. Information about these products, including adverse reactions, precautions, contra-indications and method of use can be found at: https://www.medicines.org.uk/emc/product/6334/smpc; https://www.medicines.org.uk/emc/product/3314/smpc.
Otrivine Extra Dual Relief 0.5 mg/ml + 0.6 mg/ml nasal spray, solution (xylometazoline hydrochloride, ipratropium bromide). Indications: Symptomatic treatment of nasal congestion and rhinorrhea in connection with common colds. Legal category: P. Licence holder: Haleon UK Trading Limited, The Heights, Weybridge, Surrey, KT13 0NY, UK. Information about these products, including adverse reactions, precautions, contra-indications and method of use can be found at: https:// www.medicines.org.uk/emc/product/10022/smpc.
Trade marks are owned by or licensed to the Haleon group of companies. PM-GB-OTRN-24-00124.
Xylometazoline
Xylometazoline
Offer your patients comfortable congestion relief 1
Easy-to-hold device provides accurate dosage.1
Patented technology* delivers a fine mist.** 1
Designed not to drip at the back of the throat.1
Shorter nozzle feels less invasive in the nose.†1
Otrivine with fine nasal mist** for a better patient experience† Learn more
*EP2654967B1. **Nozzle provides fine mist. †Vs previous device.
Xylometazoline Hydrochloride
Patient experience of using nasal sprays.
Adults experience on average 2-3 colds a year 2
Nasal congestion is a common symptom of colds, 2 and can negatively impact patients’ quality of life 3–7
Yet, in many countries, fewer than 1 in 2 people used nasal sprays to treat their nasal congestion 8
Patients have identified a number of challenges that discourage them from using nasal sprays to treat their congestion. These include: 1,8,9
Uncomfortable to use
Drippage down throat
Difficult to administer
Otrivine with fine mist technology.
A patented* technology that delivers a fine mist ** which feels more comfortable and gentle in the nose†1
Reaches wide to the inflamed and swollen areas in the nasal cavit y 10
Same trusted formulation
Better patient experience.†
not to drip down the
It's more comfortable,† because it's a mist,** not a blast 1
Designed not to drip at the back of the throat 1
1 thumb action – easy to use 9
2x shorter † nozzle length 1
Comfortable and controlled dosing – a precise metered dose 1
*EP2654967B1 **Nozzle provides fine mist †Vs previous device
Otrivine
Nasal Mist
Usual Nasal Spray
The role of OTC Omeprazole Tablets 20mg in the Pharmacy
Omeprazole 20mg is a key active ingredient that you will be familiar with on prescription and which is available for customers to purchase OTC.
Learning Outcomes:
Know how omeprazole works
Understand who can purchase OTC omeprazole 20mg
Be able to give additional lifestyle advice to customers
Be able to talk to GPs confidently about this opportunity
An opportunity for:
Customers
How Omeprazole works
To recommend an effective product for heartburn and acid reflux, the same strength as the prescription product.
You (Pharmacists)
To purchase an active ingredient they are familiar with – omeprazole 20mg.
To recognise the expertise of the pharmacy team to advise them on heartburn and acid reflux.
GPs
To refer customers to the pharmacy to purchase omeprazole 20mg to support the self-care agenda.
Symptoms of heartburn and acid reflux can be relieved by reducing the acidity of the stomach, which can be done through reducing or neutralising the acid. Omeprazole is a proton pump inhibitor (PPI) that acts to reduce the amount of acid produced in the stomach by blocking the proton pump of the cells in the stomach. (These produce the hydrogen used in the formation of the hydrochloric acid that causes the symptoms.)
Pharmacy expertise
By completing this training and the online module, the pharmacy team can make sure they feel confident to recommend the product and recognise when customers should be referred.
Supporting self-care
Heartburn has been identified as a condition suitable for self-care. GPs have been advised not to prescribe for short-term symptoms as patients can be given lifestyle advice and purchase effective products from their pharmacy to relieve their symptoms.
How and when to use Pyrocalm Control tablets (Omeprazole 20mg)
Pyrocalm Control Tablets (Omeprazole 20mg) can be used for the treatment of reflux symptoms.1 These include heartburn and acid reflux (when the acid from the stomach travels up to the throat).
Customers may describe having a burning sensation in their chest or an acidic taste in the mouth.2 They may notice that the symptoms are worse after eating, and when lying down or bending forward. They may also get recurrent hiccups, a hoarse voice, queasiness, halitosis or a bloated sensation.
For adults over 18 years of age
Available as a two-week supply
Directions for use:
One tablet in the morning, swallowed whole, with a glass of water
Take until symptoms have resolved (up to 14 days use only)
Can be taken with or without food
One table provides relief for up to 24 hours
Long-lasting effect
Strongest dose available OTC
IMPORTANT: It can take two to three days to achieve symptom improvement. Customers can use antacids for their symptoms while waiting for the product to have full effect.
Interactions / Cautions:
Pyrocalm Control Tablets (Omeprazole 20mg) shouldn’t be taken by customers who are using other PPIs or H2-antagonists (e.g. ranitidine). It interacts with nelfinavir. Customers with any allergies to the ingredients or previous sensitivities to other PPIs shouldn’t take Pyrocalm Control Tablets (Omeprazole 20mg). Remind customers to read the leaflet as there are other medicines that may interact. Customers taking other medicines (including herbal/supplements) should discuss these with the pharmacist.
When to refer:
A key concern is that taking omeprazole 20mg might mask the signs of something else that needs further investigation, such as a peptic ulcer or cancer.
The following should be referred to the pharmacist/GP:3
› Customers over 55 who are experiencing: symptoms for the first time; worsening symptoms; persistent symptoms; or symptoms that don’t improve with medication.
Symptoms that require referral include:
› Unexplained weight loss
› Difficulty swallowing
› Stomach pain/signs of indigestion, especially after food intake
› Blood in the vomit, or dark blood (like coffee granules) in vomit
› Black stools
› Persistent symptoms for more than four weeks.
Additional self-care advice:2
The following advice can help customers to manage their symptoms.
› Try to avoid trigger foods e.g. fatty foods, chocolate
› Avoid drinks such as coffee, alcohol and fizzy drinks
› Eat smaller portions and eat slowly, particularly avoiding large meals less than three hours before bed
› Raising the head-end of the bed at night by putting something under the mattress may help with nighttime symptoms
› Wear clothes that are loose around the waist
› If overweight, losing weight may help
› Smokers can be advised to try stopping smoking. It may also be helpful to check whether the customer has been taking non-steroidal anti-inflammatories (NSAIDs), as these can cause symptoms. You can discuss their use, and if appropriate recommend reducing the dose and trying omeprazole 20mg.
Frequently Asked Questions
Can pyrocalm control tablets (Omeprazole 20mg) be taken by pregnant women?
It can, as it is not known to be harmful,4 but customers may want to consult with their GP first.
Will GPs ask their patients to buy this?
Yes – in some cases customers may present with a referral form from their GP recommending that they purchase omeprazole 20mg.
Are there any side effects?
As with all medicines, there are potential side effects. Any new side effects should be recorded using the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.
Common side effects include headache, abdominal pain, constipation, diarrhoea, flatulence and nausea/ vomiting. Rare, but serious, signs to be aware of are: allergy, reddening of the skin and peeling (potentially Stevens- Johnson syndrome), yellowing skin/dark urine indicating liver problems, bruising/severely reduced general condition and fever (indicating changes in white blood cells).
Where in the pharmacy can customers find the product?
Customers can self-select this product from pharmacies as it is GSL, but your role in giving advice on product use, self-care and being aware of symptoms to refer is crucial.
My local GPs often prescribe this. Shall I tell them about its OTC availability?
Definitely. GPs can refer customers to your pharmacy to purchase the product if appropriate. This offers an opportunity to talk to your local GPs about who they might refer to purchase, whether they would expect any followup, and what kinds of customers they would rather were referred to the surgery instead of trying self-treatment.
What if it doesn’t work for a customer?
If they have only taken it for a short time, remind them that it can take two to three days to have full effect. If they are getting breakthrough symptoms, they can use an antacid. If they have been using it for two weeks with no effect, they should see their GP.
Further information
For further information about treating heartburn and acid reflux in the pharmacy, and customer scenarios to put your knowledge into practice, scan the QR code to view a short e-learning module online at Pharmacy Magazine.
Self test:
1. What is the strength of omeprazole in Pyrocalm Control?
A: 10mg
Pharmacy Professionals - you can use this learning as part of your revalidation.
Essential Product Information
2. How many days can it take to have full effect?
A: One to two
B: 20mg B: Two to three
3. Who of the following should be referred?
A: Customers over 55 who are experiencing symptoms for the first time.
B: Customers over 40 who are experiencing symptoms for the first time.
4. True or False:
Customers can be advised to eat slowly, avoid having a main meal within three hours of bedtime and raise the head of the bed at night to help reduce symptoms.
Pyrocalm Control® 20mg Gastro-Resistant Tablets Pharmaceutical form: Gastro-resistant tablets. Indications: For the short-term treatment of reflux symptoms in adults. Active ingredient: Omeprazole. Posology: Once daily for up to 14 days. Discontinue treatment once complete relief of symptoms has occurred. The majority of patients achieve complete relief of heartburn within 7 days. Method of administration: Take one tablet in the morning, swallowed whole with half a glass of water. Do not chew or crush the tablets. Contraindications: Children under 18 years; Hypersensitivity to the active substance, substituted benzimidazoles or to any of the excipients; nelfinavir. Special warnings and precautions for use: In the presence of any alarm symptom (e.g. significant unintentional weight loss, recurrent vomiting, dysphagia, haematemesis or melena) and when gastric ulcer is suspected or present, malignancy should be excluded. It is not recommended to co-administrate with atazanavir. Do not use concomitantly with clopidogrel. The tablets contain lactose therefore patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. Treatment may lead to slightly increased risk of gastrointestinal infections such as Salmonella and Campylobacter and, in hospitalised patients, possibly also Clostridium difficile. Consult the doctor in the following conditions: previous gastric ulcer or gastrointestinal surgery; continuous symptomatic treatment of indigestion or heartburn for 4 or more weeks; jaundice or severe liver disease; aged over 55 years with new or recently changed symptoms of indigestion or heartburn. Do not take as a preventative medication. Do not take another PPI or H2 antagonist concomitantly. Seek medical help promptly if lesions occur, especially in sun-exposed areas of the skin, and if accompanied by arthralgia. This might associate with very infrequent cases of SCLE (Subacute cutaneous lupus erythematosus). Stop using for at least 5 days before CgA measurements in laboratory test. Increased CgA level may interfere with investigations for neuroendocrine tumours. Consult your doctor before taking this medicinal product if you are due to have an endoscopy or urea breath test. Omeprazole may reduce the absorption of vitamin B12 (cyanocobalamin) in patients with risk factors. Interaction with other medicinal products and other forms of interaction: atazanavir, digoxin, clopidogrel, posaconazole, erlotinib, ketoconazole, itraconazole, saquinavir, ritonavir, tacrolimus, methotrexate. Active substances metabolised by CYP2C19 such as: vitamin K antagonists (R-warfarin, cilostazol, phenytoin and diazepam). Active substances known to inhibit CYP2C19 or CYP3A4 (such as clarithromycin and voriconazole). Active substances known to induce CYP2C19 or CYP3A4 or both (such as rifampicin and St John’s wort). Concomitant administration of omeprazole with nelfinavir is contraindicated. Use during pregnancy and lactation: can be used during pregnancy and breastfeeding. Effects on ability to drive and use machines: None expected. Adverse drug reactions such as dizziness and visual disturbances may occur. If affected, patients should not drive or operate machinery. Side effects: The most common side effects (1-10% of patients) are headache, abdominal pain, constipation, diarrhoea, flatulence and nausea/vomiting. Another common side effect is fundic gland polyps (benign). Uncommon side effects: Insomnia, dizziness, paraesthesia, somnolence, vertigo, increased liver enzymes, dermatitis, pruritus, rash, urticarial, malaise and peripheral oedema. Rare side effects: Hypersensitivity reactions e.g. fever, angioedema and anaphylactic reaction/shock; leukopenia, thrombocytopenia, hyponatraemia, agitation, confusion, depression, taste disturbance, blurred vision, bronchospasm, dry mouth, stomatitis, gastrointestinal candidiasis, microscopic colitis, hepatitis with or without jaundice, alopecia, photosensitivity, arthralgia, myalgia, interstitial nephritis, increased sweating. Very rare side effects: agranulocytosis, pancytopenia, hypomagnesaemia, aggression, hallucinations, hepatic failure, encephalopathy in patients with preexisting liver disease, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN), muscular weakness, gynaecomastia. Side effect with ‘Not known’ frequency: Subacute cutaneous lupus erythematosus. Legal Category: GSL. Price: 7 Tablets £5.83, exc. VAT, 14 Tablets £9.16 exc. VAT Product licence number and holder: PL 14017/0277 Dexcel® Pharma Ltd., 7 Sopwith Way, Drayton Fields, Daventry, UK. Date of preparation: October 2019. Pyrocalm Control Tablets is a registered trademark.
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Answers: 1 B, 2 B, 3 A, 4 True
Sales Enquiries: trade.support@venture-life.com
Marketing Enquiries: marketing@venture-life.com
Customer Service: customercare@earol.co.uk
Life Group plc, 12 The Courtyard, Eastern Road, Bracknell, Berkshire, RG12 2XB
Introduction
Earol® provides effective and clinically proven results, aiding the removal of earwax, supporting ear hygiene and soothing and preventing itchy and irritated ears.
Clinically proven to soften and remove impacted earwax to prepare the ear canals for clinical dewaxing, Earol® is recommended by 93% of Ear Care Specialists** and is Britain’s Number 1 Earwax Removal Spray*.
The Earol® range consists of 5 products, used throughout your ear care journey, from looking after your little ones’ ears, to preparing for wax removal as well as providing relief from water trapping and relieving irritation after wax removal. Due to the natural properties of our range, our products are suitable for most people.
Aiding the Wax Removal Process
The wax removal industry has grown in prevalence over recent years, due to the privatization of the service. Before, patients were able to regularly have their ear wax removed by NHS practitioners, this has now moved predominantly into the private healthcare space. Around 2.3M people in the UK require wax removal per year, the incidence of this can range from every month to every 6 months to once a year*
Once ear wax has built up, the substance can be very hard and dry in the ear, making it difficult, if not impossible to remove without prior action. The wax needs to be softened prior to removal so that it easily is removed from the ear canal without causing any pain, injury or irritation. This is where cerumenolytics come in, such as Earol®. These oily substances help to break down and soften the ear wax, and also lubricate the ear canal making it easier to remove the wax in practice.
Although there are many cerumenolytics as well as other wax removal products on the market, Earol® is different. Why? Earol® is made up of pharmaceutical grade olive oil and mineral oil, and is delivered via a 0.05ml patented metered dose spray. This means that on actuation the user gets the same dose every time. The dose is tried and tested to instantly adhere to the ear canal walls, and will not drip out of the ears, unlike ear drops which deliver a much larger, usually unmeasured dose, known to cause leakage and ineffective treatment. In addition to this, the tapered actuator of the Earol® bottle is a tried and tested safety mechanism, used to avoid ear drum perforation.
The Earol® range consists of the following products:
Suitable for babies aged 6 months and above, clinically proven to soften and naturally remove ear wax. Soothes itchy and irritated ears, delivered via a metered dose spray.
Clinically proven to soften ear wax, aiding wax removal and preventing future wax build up, delivered via a metered dose spray, made from a gentle blend of pharmaceutical-grade olive oil and mineral oil.
Delivered via a metered dose spray, used to soothe and hydrate the skin of the ear canal after wax removal. Suitable for use on very dry skin, helping to prevent itchiness and dryness.
Clinically proven and suitable for sensitive skin, used to soften and naturally remove earwax, preventing and soothing dry and itchy ears, and used to enhance ear hygiene.
A metered dose spray containing a blend of pharmaceutical-grade olive oil and tea tree oil, to protect the ear from water trapping during water-based activities. A minimum of 6 hours protection.
Baby Earol®
Earol® Olive Oil Spray
Earol® Almond Oil Spray
EarolSwim®
Earol® Aftercare Spray
RECOMMENDATION
RECOMMEND
CHEST BURNING 1,2 SOUR TASTE 1,2
DOUBLE ACTION FOR 7 SYMPTOMS OF HEARTBURN & INDIGESTION 1,3 PROVIDES FAST ACTING AND LONG-LASTING RELIEF3,7 DOUBLE ACTION
*Associated with acid reflux.
References: 1. Heading, RC, et al. Eur J Gastroenterol Hepatol. 2016;28:455-462. 2. Heartburn and acid reflux. NHS UK. Available at: https://www.nhs.uk/conditions/heartburn-and-acid-reflux/ Accessed July 2023. 3. Gaviscon Double Action Mint Oral Suspension. Summary of Product Characteristics. Available at: https://www.medicines.org.uk/emc/product/5609/smpc Accessed July 2023. 4. Watanabe M, et al. BMC Gastroenterol. 2017;17:92. 5. Indigestion. NHS UK. Available at: https://www.nhs.uk/conditions/indigestion/ Accessed July 2023. 6. Broderick R, et al. Dig Dis. 2020;38.188-195. 7. Dettmar, PW, et al. Drug Dev Ind Pharmacy. 2018;44:30–39.
Essential Information: GAVISCON DOUBLE ACTION ANISEED ORAL SUSPENSION: Contain per 10 ml: Sodium alginate 500 mg, sodium bicarbonate 213 mg and calcium carbonate 325 mg (GSL). Indications: Treatment of symptoms resulting from the reflux of acid, bile and pepsin into the oesophagus such as acid regurgitation, heartburn and indigestion, for example following meals or during pregnancy, and for symptoms of excess stomach acid (hyperacidity). Can also be used to treat the symptoms of gastro-oesophageal reflux during concomitant treatment with or following withdrawal of acid suppressing therapy. MAH: Reckitt Benckiser Healthcare (UK) Ltd, HU8 7DS, United Kingdom. Information about this product including adverse reactions, precautions, contraindications and method of use can be found at: www.medicines.org.uk/emc/product/685/.
GAVISCON DOUBLE ACTION MINT FLAVOUR CHEWABLE TABLETS: Each tablet contains sodium alginate 250 mg, sodium bicarbonate 106.5 mg and calcium carbonate 187.5 mg (GSL). Indications: Treatment of symptoms resulting from the reflux of acid, bile and pepsin into the oesophagus such as acid regurgitation, heartburn and indigestion, for example following meals or during pregnancy, and for symptoms of excess stomach acid (hyperacidity). Can also be used to treat the symptoms of gastro-oesophageal reflux during concomitant treatment with or following withdrawal of acid suppressing therapy. MAH: Reckitt Benckiser Healthcare (UK) Ltd, HU8 7DS, United Kingdom. Information about this product including adverse reactions, precautions, contraindications and method of use can be found at: https://www.medicines.org.uk/emc/product/5329.
Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard, or search for the MHRA Yellow Card in the Google Play or Apple App Store. Adverse events should also be reported to Reckitt Benckiser Healthcare (UK) ltd on: 0333 200 5345
Summary of Terms
1. Where accounts have been approved for credit, payments are due 30 days from the month of invoice. Sigma Pharmaceuticals Plc reserves the right to charge interest on overdue accounts at the rate of 4% above the LIBOR (London InterBank Offered Rate) per month without prejudice to the right of recovery. Cheques payable to Sigma Pharmaceuticals Plc. Sigma Pharmaceuticals Plc reserves the right not to process the orders in case of an overdue account.
2. All orders and prices quoted are subject to the standard rate or reduced rate of V.A.T. on the NETT invoice value. The invoice date is the tax point for V.A.T. purposes.
3. Products on offer in the PLOF are not eligible for any further discounts.
4. All delivery enquiries must be notified within 24 hours of delivery
5. Prices are correct at time of going to print, but are subject to change without prior notice. Sigma Pharmaceuticals Plc reserves the right to amend any of their prices without due notice. Orders are accepted on condition that the goods will be invoiced at the prices ruling at the date of delivery. All images shown are for illustrative purposes only.
6. Invoice queries must be raised within one week of invoice date.
7. The goods shall remain the sole and absolute property of the seller and legal equitable owner until such time as the buyer shall have paid to the seller the agreed price together with the full price of any other contract with the seller.
8. Standard terms and conditions apply, as per trading terms, available upon request.
9. RSP’s shown are supplied by the manufacturers and are correct at time of going to print. It is at the retailers discretion to set their own retail price and margin.
Claims and Returns
DELIVERIES
When accepting your delivery please ensure the number of boxes/bulk received match the drivers runsheet and that any discrepancies are clearly marked. Non-delivery must be notified to Sigma Pharmaceuticals Plc within 1 service day of invoice date or advice of despatch.
RETURNS
Under existing rules and regulations issued by the DHSS and as published in “MAIL”, goods will only be accepted for return by Sigma Pharmaceuticals Plc for the following reasons:
• To correct an error in delivery or ordering.
• In response to a product or batch recall instigated by a manufacturer.
• Where products or packages are alleged to be faulty.
In order to be considered for credit or replacement the goods must be accompanied by a note showing:-
• The name and address of the customer returning the goods.
• The quantity and description of the goods.
• The invoice number on which the goods were supplied.
• The reason of the return.
Transfer Order Queries
Call 01923 331 411 and ask for the Transfer Order Department.
Expiry Date Queries
Dates on products should be checked upon delivery. If you wish to return an item due to the date, please follow the return procedure mentioned previously.
Items Missing From Delivery
Call 01923 444 999 within 24 hours of delivery.
Wrong Item Supplied
Mark the required item with the code of ‘B’ on your invoice/return slip.
Goods Ordered in Error
Mark the item with the code of ‘H’ on your invoice/return slip.
Goods Arrived Damaged
Mark the item with the code of ‘F’ on your invoice/return slip.
Recall Stock
All recall stock must be written on a return slip with the date, quantity and reason code K.
OTC & HEALTH AND BEAUTY TRANSFER ORDER OVERVIEW
Sigma offers a comprehensive transfer order service offering prompt deliveries, transparent invoicing and full advantage of manufacturers multi-level discounts (MLD) across a wide range of manufacturers.
WHY USE SICMA FOR TRANSFER ORDERS?
Our transparent invoice structure, quick turnaround and dedicated customer service means we are the preferred choice with manufacturers and third-party sales teams for transfer orders. Advantages of putting your transfer orders through Sigma:
> A minimum of 10% wholesaler discount on transfer orders)(-.
> Transparent discount structure
> More than 95% of products are available to order in singles
> Aim to deliver stock within 48 hours from receipt
> Back orders held for 60 days
> Dedicated transfer order team that can be directly contacted by telephone or email.
> Committed to ensure transfer order queries are resolved within 72 hours "Ethical and Rx Lines may not qualify for this discount
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Lisa Farrant OTC Transfer Orders
Tel: 01923 331 411
Email: lisa@sigmaplc.com
OTC Transfer Orders
Michelle Sparrow, Business Development Manager
Tel: 01923 332 790
Sales Executives
Tel: 01923 332 790
Email: michelle@sigmaplc.com
Email: michelle@sigmaplc.com
Simone Elkerton OTC Transfer Orders
Tel: 01923 331 411
Pankaj Vyas - North London up to Midlands
Sales Executives
Tel: 07946 352 462
Business Development
Email: sim@sigmaplc.com
Sales Executives
Email: pankaj@sigmaplc.com
Lisa Farrant OTC Transfer Orders
Reshma Patel - North East & South London
Tel: 01923 331 411
Tel: 07767 163 171
Email: lisa@sigmaplc.com
Email: reshma@sigmaplc.com
Tel: 01923 444 999
Pankaj Vyas - North London up to Midlands
Email: bd@sigmaplc.com
Specials
Tel: 07946 352 462
Pankaj Vyas - National Sales Manager
Tel: 07946 352 462
Email: pankaj@sigmaplc.com
Email: pankaj@sigmaplc.com
Hinal Pandya, Specials Manager
Tel: 0800 597 4475
Email: specials@sigmaplc.com
Hinal Pandya, Specials Manager
Reshma Patel - North East & South London
Tel: 07767 163 171
Vithal Adatia - Account Executive
Email: reshma@sigmaplc.com
Tel: 01923 331 407
Email: vithal@sigmaplc.com
Hinal Pandya, Specials Manager
Tel: 0800 597 4475
Transfer Orders
Tel: 0800 597 4475
Email: specials@sigmaplc.com
Email: specials@sigmaplc.com
Simone Elkerton OTC Transfer Orders
Tel: 01923 331 411
OTC Transfer Orders
Email: sim@sigmaplc.com
Simone Elkerton OTC Transfer Orders
Lisa Farrant OTC Transfer Orders
Tel: 01923 331 411
Email: lisa@sigmaplc.com
Lisa Farrant OTC Transfer Orders
Simone Elkerton OTC Transfer Orders
Tel: 01923 331 411
Tel: 01923 331 411
Email: sim@sigmaplc.com
Email: sim@sigmaplc.com
Lisa Farrant OTC Transfer Orders
Tel: 01923 331 411
Email: lisa@sigmaplc.com
Tel: 01923 331 411
Email: lisa@sigmaplc.com
Alka-Seltzer® Original contains acetylsalicylic acid. Indication: For the rapid relief of pain including migraine, headache, period pains, neuralgia, toothache, sore throat; the symptomatic relief of rheumatic pain, sciatica, lumbago, fibrositis, muscular aches and pains; the symptomatic relief of influenza, feverishness, and feverish colds. MA Holder: Bayer plc, 400 South Oak Way, Reading, RG2 6AD, UK (information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at https://www.medicines.org.uk/emc/product/13691/smpc). Legal Category: GSL. Date of Preparation: May 2023
*Bodyform voted No.1 for comfort by 69%, and No.1 for protection by 66%, of those surveyed compared with other brands they had previously tried. In-home trial with 325 women aged 18-55, Nov23. Verify at www.bodyform.co.uk/verify. †Cour-V™ Adaptive Technology: Winner Period Care Category. Survey of 8,000 people in UK &
ROI by Kantar.
The UK’s #1 BV Treatment*
How Balance Activ® BV Treatment Gel and Pessaries works:
Not a drug: Mimics the vagina’s own defence mechanism to treat and relieve BV, naturally.
Reliable: Clinically proven to work, for a dependable natural alternative.
Effective: Replenishes the body’s natural lactic acid to restore the vagina’s normal pH, rapidly relieving symptoms.
Balance: Tops up glycogen to encourage good bacteria and maintain pH balance to keep BV at bay.
Convenient: Comes with 7 single-use, gel-filled tubes –a week’s treatment – for easy and hygienic application.
*Source:
The naturally working treatment for Bacterial Vaginosis: Available in 2 easy to use formatspessary & gel for added convenience.
Balance Activ Thrush Cream is not a drug, but a treatment with 3 benefits designed to help the body fight the cause, relieve the symptoms, and prevent the recurrence of thrush.
Thrush Cream
How Balance Activ® Thrush Cream works:
Not a drug: 3 benefits in 1 treatment to help the body fight the cause, treat the symptoms, and prevent thrush.
Protects: Restricts the growth of harmful bacteria, allowing the body to fight the cause.
Relieves: Provides relief from intimate itching, redness, and soreness.
Prevents: Retores and maintains a balanced vaginal pH and flora to prevent thrush from recurring.
Simple: No fragrance and paraben added.
Convenient: Includes 5 single-use applicators for easy insertion. Can also be used externally.
TREATMENTS FOR THRUSH IN WOMEN TOPICAL COMBI RANGE
Presentation: Powder for reconstitution with 200 ml water containing glucose 3.56 g, sodium chloride 0.47 g, potassium chloride 0.30g, disodium hydrogen citrate 0.53 g in each sachet. Indications: GSL: For the treatment of fluid and electrolyte loss associated with acute diarrhoea. P: Oral correction of fluid and electrolyte loss in infants, children and adults. Treatment of watery diarrhoea of various aetiologies including gastroenteritis in all age groups. MA holder: Phoenix Labs, Suite 12, Bunkilla Plaza, Bracetown Business Park, Clonee, Co. Meath, Ireland. Further information is available from: Phoenix Labs. Always read the label. Tel +3531 5742410, email: medical information@phoenixlabs.ie.
Legal category: Dioralyte Natural (GSL) D ora yte Blackcurrant (GSL)Dioralyte Citrus (GSL), D oralyte Natura Sachets (P), D ora yte
Blackcurrant Sachets (P), Dioralyte Citrus Sachets (P). Information about these products including adverse reactions, precautions, contraindications and method of use can be found at:
Presentation: Powder for reconstitution with water containing pre-cooked rice powder 6 g, sodium citrate 580 mg, sodium chloride 350 mg, potassium chloride 300 mg in each sachet. Indications: GSL: For the treatment of fluid and electrolyte loss associated with acute diarrhoea. P: Oral correction of fluid and electrolyte loss in infants aged 3 months upwards, children and adults. Treatment of watery diarrhoea of various aetiologies including gastroenteritis from 3 months upwards. Particularly recommended in the case of too loose or frequent stools where it enables over-loose stools to revert to normal.
MA holder: Phoenix Labs, Suite 12, Bunkilla Plaza, Bracetown Business Park, Clonee, Co. Meath, Ireland. Further information is available from: Phoenix Labs. Always read the label. Tel +3531 5742410, email: medical information@phoenixlabs.ie.
Dioralyte Relief Raspberry GSL. Information about these products including adverse reactions, precautions, contraindications and method of use can be found at:
tackle gum disease early by enhancing your patients’
8 benefits for Optimal Gum Health*:
Helps stop and prevent bleeding gums
Reduces red and inflamed gums
4x more effective at removing plaque**
Works to keep the seal between gums and teeth tight
Targets bad breath
Strengthens enamel with a mineral accelerator
Deep cleans for a fresh feeling
Gently whitens
Corsodyl Complete Protection:
Softens plaque for easy removal via its unique formulation of 67% sodium bicarbonate1-3
Improves bleeding sites significantly2,3† With 1400 ppm fluoride for everyday use
& prevent
Short term intensive treatment for gum disease
†† Data on file 2024. For verification contact mystory.gb@haleon.com
Product Information: Corsodyl 0.2% Mouthwash (Alcohol Free). Active Ingredient: Chlorhexidine digluconate. Indications: Plaque inhibition; gingivitis; maintenance of oral hygiene; post periodontal surgery or treatment; aphthous ulceration; oral candida. Legal category: GSL. Licence Holder: Haleon UK Trading Limited, Weybridge, KT13 0NY, U.K.
Information about this product, including adverse reactions, precautions, contra-indications and method of use can be found at: https://www.medicines.org.uk/emc/medicine/23034 Trademarks are owned by or licensed to the Haleon group of companies. PM-GB-CSYL-24-00234
Natural Ear Care for the Whole Family
Britain’s No.1 Earwax Removal Spray*
Earol® Olive Oil Spray
Clinically proven to soften ear wax, aiding wax removal and preventing future wax build up, delivered via a metered dose spray, made from a gentle blend of pharmaceutical-grade olive oil and mineral oil.
Baby Earol®
Suitable for babies aged 6 months and above, clinically proven to soften and naturally remove ear wax. Soothes itchy and irritated ears, delivered via a metered dose spray.
A metered dose spray containing a blend of pharmaceutical-grade olive oil and tea tree oil, to protect the ear from water trapping during water-based activities. A minimum of 6 hours protection.
Earol® Aftercare Spray
Almond Oil Spray
Clinically proven and suitable for sensitive skin, used to soften and naturally remove earwax, preventing and soothing dry and itchy ears, and used to enhance ear hygiene.
Delivered via a metered dose spray, used to soothe and hydrate the skin of the ear canal after wax removal. Suitable for use on very dry skin, helping to prevent itchiness and dryness.
EarolSwim®
Earol®
#1 Skin Treatment Brand*
Cracked and itchy skin are two of the most common symptoms associated with
E45 Itch Relief Gel & Coolmouse
Cools & Soothes itchy skin in under 60 seconds
E45 Itch Relief Cream
Scientifically proven to provide effective relief for itchy skin caused by eczema, dermatitis and pruritus.
Total Coverage, Value Sales, MAT w.e 13.07.24
Complete Emollient Shower Regime
Bath Oil
Tested by dermatologists to help with dry skin conditions, E45 Bath Oil creates a lasting barrier that protects against moisture loss.
Shower Cream
Designed to help protect your skin from further drying, leaving it feeling soft and smooth.
Dry Scalp Shampoo
Dermatologically tested and specially formulated to work for both dry flaky scalps and dandruff, gently cleansing your scalp.
In 2020, Somex Pharma launched Eropid which is an over the counter Pharmacy (P) medication used to treat erectile dysfunction . It is therefore available to buy in the pharmacy without a prescription.
In
Recommend Eropid and increase your profits
Available in packs of 2, 4 and 8 tablets
It has a three year shelf life
BIG mark-up for Pharmacy – more than 100%
Available to order from Sigma
Recommend Eropid and increase your profits
precautions, contra-indications, and method of use can be found at: www.medicines.org.uk/emc/product/2255
Iron contributes to the reduction of tiredness and to the normal function of the immune system
• No preservatives, colourings or artificial flavourings
• Non constipating liquid formula
• Highly absorbable iron gluconate
• Vitamin C to increase iron absorption
• Suitable for vegetarians
• Suitable during pregnancy and breastfeeding
The Iron Role of Iron Role
The body cannot make iron, so we must acquire it through the diet. Women usually have a greater need for iron due to monthly blood loss during menstruation and also when giving birth.
The need for iron is particularly high for pregnant and breastfeeding women.
The following symptoms may signal an iron deficiency and a need to check iron levels:
• Persistent tiredness
• Concentration problems
• Lack of energy
• Pale skin
• Brittle hair and nails
Iron can:
• Contribute to the reduction of tiredness and fatigue
• Contribute to the normal formation of red blood cells and haemoglobin
• Contribute to normal oxygen transport in the body
• Contribute to normal energyyielding metabolism
• Contribute to normal function of the immune system
The Benefits of Floradix Liquid Iron
• Contains iron gluconate which is a highly absorbable form of iron
• Contains vitamin C and fruit concentrates to aid iron absorption further
• Herbal extracts, from nettle, carrots and spinach help maintain a healthy digestion and provide further trace elements
• B-vitamins support blood formation and energy release
• Fruit juices give Floradix a pleasant taste
• Floradix is free from chemical preservatives, colourings and alcohol
Also Available
Floradix
Iron Tablets
Convenient for those on the go!
Floradix
Floravital Liquid
A yeast- and glutenfree version of Floradix for those people with intolerances to yeast and gluten.
Floradix
Kids Liquid
Our acerola and raspberry flavoured formula for children with vitamins C, B1, B2, B6, B12 and niacin to support cognitive functions. Suitable for children aged 3 years and over plus vegans.
FUSION™ Allergy
Nasal Spray for the prevention and treatment of hayfever symptoms such as runny nose, sneezing and nasal congestion.
• Suitable for all ages (including newborns)
• Suitable for use in pregnancy and breastfeeding
• 2% Ectoin®
FUSION™ Allergy
Eye Drops for the prevention and treatment of hayfever symptoms such as irritated, watery and red eyes.
• Suitable for all ages (including newborns)
• Contact lens compatible
• Suitable for use in pregnancy and breastfeeding
• 1% Ectoin®
• Single-dose units
UK: 0808
FUSION™ Allergy
Day & Night Eye
Gel for the prevention and treatment of hayfever symptoms such as dry, irritated, watery and inflamed eyes.
• Suitable for all ages (including newborns)
• Contact lens compatible
• Suitable for use in pregnancy and breastfeeding
• 2% Ectoin®
• Multi-dose bottle
FUSION™ Allergy
Eye Spray for the prevention and treatment of hayfever symptoms such as dry, irritated, watery and inflamed eyes.
• Suitable for all ages (including newborns)
• Contact lens compatible
• 2% Ectoin®
• Spray onto closed eyes
FUSION™ Allergy Cooling Mask for the prevention and treatment of hayfever symptoms such as puffy and inflamed eyes, congestion and headaches.
• Suitable for all ages (including newborns)
• Suitable for use in pregnancy and breastfeeding
• Hydro-Cool Beads Cooling Mask
FyboCalm helps RELIEVE and PREVENT gut symptoms recurring†1-4
FyboCalm Wind & Bloating Relief
Relieves wind, bloating and abdominal pain in 2 hours, for relief up to 8 days 3
FyboCalm Diarrhoea Relief
Long-lasting relief for IBS related diarrhoea 1,2
Clinically Proven1-4
Learn More about FyboCalm's Unique Mode of Action
†Wind & Bloating and IBS type symptoms such as Constipation and Diarrhoea.
FyboCalm is a medical device. Always read the instructions.
FyboCalm Constipation Relief
Long-lasting relief for IBS related constipation 4,5
REFERENCES: 1. Ciriza de los Rios CC, et al. Ther Adv Gastroenterol. 2021; 14: 1-10. 2. Trifan A. et al. UEG Journ. 2019: 7(8); 1093-1101. 3. Petrisor DC et al. Dig Dis Sci. 2024 Jan;69(1):161-168. 4. Etropolska Z, Poster presented at the Digestive Disease Week; 2023; May 6–9; Chicago, IL. 5. Filippone A, et al. J ClinMed. 2022; 11(23): 7073.
July 2024
• For adults and children aged 12 years and over
• Available without prescription – only in pharmacies
• Lasts 24 hours
• Acts within 1 hour
One tablet daily
Lactose, gluten free
3 years shelf life
Available in 10’s & 30’s
Product Name: Histahive 180mg Film-Coated Tablets Active ingredient: Fexofenadine Hydrochloride. Indication: indicated in relief of symptoms with chronic urticaria. Always read the label or accompanying leaflet. Legal classification: P MA Holder: Dr Reddy’s Laboratories (UK) LTD. 410 Cambridge Science Park, Milton Road, Cambridge, CB40PE Further Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at: https://www.medicines.org.uk/emc/product/100389/smpc# about-medicine. Adverse events should be reported. Reporting forms and information can be found at yellowcard.mhra.gov.uk. Adverse events should also be reported to Pharmacovigilance at Dr Reddy’s via DrreddysGB@EU. Propharmagroup.com 2025-HHV-012 - Last revised 16.1.2025.
• For adults and children aged 12 years and over • Lasts 24 hours
• Acts within 1 hour • One tablet daily • Non-drowsy in most people
Lactose, gluten free
3 years shelf life • Available in 10’s & 30’s
CHANGING SIZE BOTTLES ARE
THE UK’S NO. 1 GLUCOSE SHOT*
Lift Glucose Shots, consumed all at once, contains a 15g of glucose, your body’s preferred source of energy.
Easy-to-take liquid form, to offer an immediate solution.
Fast-acting natural glucose, is caffeine, taurine, gluten and fat free. Suitable for vegans.
Convenient and pocket-friendly, it's perfect for those with diabetes - keep inyour bag or car for when needed.
Available in 4 tasty flavours.
Also available in chewable tablet in tubs of 10s & 50s
These chews offer 3.7g of fast-acting glucose per tablet, so for those with diabetes. Chew three to four tablets when needed.
Distributor: Maxwellia Ltd. Classification: P. Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at www.lovima.com/hcp/lovione.
from Cold, Allergies,
Fever, Nasal & Sinus Symptoms
Over The Counter Products
(No Prescription Required) Helps Alleviate:
•Nasal Symptoms from Allergies & Hay Fever
•Nasal Symptoms from Cold & Flu
•Post Nasal Drip
•Sinus Pressure & Nasal Stuffiness
•Allergies from Occupational and House Dust, Fumes, Animal Dander, Grass, Pollen, Smoke, etc.
•Nasal Symptoms in CPAP Users with Sleep Apnoea
•To Loosen Thick Nasal Mucous Symptoms seen in Cystic Fibrosis and Immotile Ciliary Syndrome
Nuromol provides more effective pain relief than a prescription combination of paracetamol and codeine 1*
Nuromol gets to work faster than individual tablets of standard ibuprofen and paracetamol taken together 2–7 †
References: 1. Daniels SE, et al Pain. 2011;152:632–642. 2. Tanner T, et al. BMC Clin Pharmacol. 2010;10:10. 3. Wright CE, et al. Clin Pharmacol Ther. 1983;34(5):707-710. 4. Yue Y, et al. Clin Ther. 2013;35(9):1306-1320. 5. Rostami-Hodjegan A, et al. Drug Dev Ind Pharm. 2022;28(5):523-531. 6. Atkinson HC, et al. J Bioequivalence & Bioavailab. 2015;7:3. 7. Tarabar S, et al. Drugs R D. 2020;20:23-37. 8. Nuromol Pain Relief 200 mg/500 mg Film Coated Tablets. Summary of Product Characteristics. Updated June 2022. Accessed January 2023. 9. Survey of Community Pharmacists Aug-Sep 2022. 10. Mehlisch D, et al. Clin Ther. 2010;32(5):882-895. 11. Mehlisch D, et al. Clin Ther. 2010;32(6):1033-1049.
Essential Information
Nuromol Pain Relief 200 mg/500 mg film coated tablets For the temporary relief of mild to moderate pain associated with migraine, headache, backache, period pain, dental pain, rheumatic and muscular pain, pain of non-serious arthritis, cold and flu symptoms, sore throat and fever. This product is especially suitable for pain which has not been relieved by ibuprofen or paracetamol alone. Nuromol Pain Relief 200mg/500mg Film Coated Tablets is indicated in adults aged 18 years. Licence Holder: Reckitt Benckiser Healthcare (UK) Limited, Slough, SL1 3UH. Legal Classification: P. Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at https://www.medicines.org.uk/emc/product/13804.
Adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard, or search for the MHRA Yellow Card in the Google Play or Apple App Store. Adverse events should also be reported to Reckitt Benckiser Healthcare (UK) ltd on: 0333 200 5345
RKT-M-09246 January 2022
Olbas has a strong heritage and is a familiar brand, helping families for generations. With a range of winter remedies suitable for the whole family, Olbas is perfectly placed to help boost sales at peak times.
time use. Indications: For the treatment of acute bacterial conjunctivitis in
Tavistock Square, WC1H 9LT, UK. Information about this product, including adverse reactions, precautions,
https://www.medicines.org. uk/emc/product/7299/smpc. All adverse events should be reported. Reporting forms and information can be found at www.mhra.gov.uk/yellowcard. Adverse events should also be reported to Reckitt Benckiser Healthcare (UK) Ltd on: 0333 200 5345. Date of preparation: November
The UK’s No.1 Healthcare Professional Recommended Hydration Tablet
WHY RECOMMEND O.R.S HYDRATION?
PROVEN
Our scientifically proven formula of electrolytes follows the World Health Organisation’s guidelines for rehydration.
TRUSTEDTASTES GREAT
We are the only hydration Tablets that can be prescribed by doctors in the UK.
We spent over 50 rounds of taste testing to get our natural flavours just right.
Formula based on the World Health Organization rehydration guidelines.
Most widely prescribed proton pump inhibitor (PPI)1
Most effective PPI treatment for maintenance of GERD2
Can be used during pregnancy and whilst breast feeding
Omeprazole, the 2nd most dispensed item in England3
Care should be taken when recommending medicines for use in pregnancy as medicines can cross the placenta and may affect the fetus.
Product Authorisation Holder: Dexcel® Pharma Ltd. 7 Sopwith Way, Drayton Fields, Daventry, Northamptonshire NN11 8PB, United Kingdom. Legal classification: GSL. Product name: Pyrocalm Control® 20mg Gastro-Resistant Tablets. Ingredients: 20 mg Omeprazole. Indications: For the short-term treatment of reflux symptoms (e.g. heartburn, acid regurgitation) in adults. Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at: www.medicines.org.uk/emc/product/9154. Fertility, pregnancy and lactation: Pregnancy: results from three prospective epidemiological studies (more than 1000 exposed outcomes) indicate no adverse effects of omeprazole on pregnancy or on the health of the foetus/newborn child. Omeprazole can be used during pregnancy. Breastfeeding: Omeprazole is excreted in breast milk but is not likely to influence the child when therapeutic doses are used. Omeprazole can be used during breastfeeding. Fertility: Animal studies with the racemic mixture omeprazole, given by oral administration do not indicate effects with respect to fertility. 1NHS Digital, Practice level prescribing data 2018/19 2pubmed.ncbi.nlm.nih.gov/9692700/ 3www.statista.com/statistics/378445/ prescription-cost-analysis-top-twenty-chemicals-by-items-in-england/
*compared to Senokot 7.5mg Adult Tablets
Senokot Max Strength Tablets 12 Years Plus: Each tablet contains powdered Alexandrian Senna fruit (pods) and Tinnevelly Senna fruit (pods) equivalent to 15mg hydroxyanthracene glycosides, calculated as sennoside B. Indications: For the short-term relief of occasional constipation. Legal Category: P. MA Holder: Reckitt Benckiser Healthcare (UK) Ltd, Hull, HU8 7DS. Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be found at: https://www.medicines.org.uk/emc/product/11549/smpc RT-M-4ubwux
PRODUCTS NOW AVAILABLE
6 DAY EARLY PREGNANCY
High sensitivity Midstream pregnancy test which can detect hCG in the urine as early as 6 days prior to the expected period date.
BLOOD PRESSURE MONITOR
Simple user-friendly blood pressure monitor which can store blood pressure readings for two users. Also includes irregular heartbeat detection. Product includes batteries and one year warranty.
TWIN MIDSTREAM PREGNANCY
Rapid Midstream pregnancy test delivers results in 1-3 minutes which can detect hCG in the urine as early as 4 days prior to the expected period date.
DIABETES SCREENING
A rapid, convenient and cost-effective method for the indirect measurement of blood sugar levels to assist in the diagnosis and management of diabetes. Contains three test strips.
TWIN STRIP PREGNANCY
Can be carried out by collecting urine and ‘dipping’ the test in the sample, over 99% accurate.
HEALTH CHECK-UP
A rapid, ten parameter, low-cost solution to evaluate a number of conditions affecting kidney, liver and heart etc. Six dipstick tests included.
URINARY TRACT INFECTION TEST
Urinary tract infections (UTIs) are common infections which affect the urinary tract, including the bladder (cystitis) urethra (urethritis) or kidneys (kidney infection). Suresign urinary tract infection test strips can aid in the detection of elevated levels of Leukocytes or Nitrites in urine, indicating inflammation or potential bacterial infection in the patient. Contains three dipstick tests.
SUPERIOR PROTECTION
WITH SURPRISING DISCRETION
The UK’s No1 Bladder Weakness Brand*
Key Product Benefits:
The entire range provides long lasting dryness.
It’s designed to be safe and kind to the skin.
Offers the protection you’d expect from a TENA product.
Dermatologically tested and perfume free
TENA discreet effectively locks in moisture for up to 12 hours offering your customers superior protection day or night. 1 in 3 women experience bladder weakness at some point in their life. Help women find the right purpose-made product for their needs and provide your customers with protection that’s trusted by millions.
Source: Bladder Weakness RSV% by Brand and Sub-Brand - Nielsen data to 05.08.23
New
For dry mouth –when just water is not enough
1 in 5 suffer from dry mouth, and water is usually the standard remedy. But for many people, water only provides brief relief.
TePe’s new hydrating mouthwash and mouth gel ease the feeling of dry mouth, provides comfort, and protects teeth. We recommend the gentle, unflavoured products for those with a very dry mouth and mildly flavoured products for those with moderate problems.
TePe® Hydrating Mouthwash
TePe’s mouthwash moistens the mucosa and leaves a pleasant feeling in the mouth. Not only does it help with dry mouth, but the added 0.2 % fluoride also gives that extra protection against caries.
TePe® Hydrating Mouth Gel
TePe mouth gel gives immediate and long-lasting comfort*, moistens and soothes the oral mucosa and is convenient and easy to use whenever you need it – great for on-the-go.
TePe® Hydrating Spray
A saliva stimulating spray that offers refreshment for people who experience dry mouth. It immediately stimulates saliva and provides a moisturised, refreshed feeling. The spray contains xylitol and fluoride to help protect against cavities. The TePe Hydrating Mouth Spray has a mild apple/peppermint flavour, is easy to use on-the-go, whenever freshness is needed.
*The duration of the comfort is individual; people with no or very little saliva usually experience a more prolonged effect.
