Inducer
Sensor
Mediator
Effector
DNA Sensor Receptor RIG-I Like Receptor (RLR)
DNA Binding RIG-I (DNA Helicase)
Domain CARD
ZBP1 (Z Form)
ZBP1/DAI
HIN200 (dsRNA) * RHIM: (RIP Homotypic Interaction Motif) AIM2
Inducer
Sensor
Pathway
Effector
MAVS (mt)
FADD →IKK(NEMO) TRAF →TBK1
NFB IRF3 →Type 1 IFN
RHIM RHIM
…→TBK1 KD→IKK(NEMO)
IRF3 →Type 1 IFN NFB
PYD PYD-CARD
…→Procaspase1→Caspase 1
IL-18, IL-1
Mediator
Effector
Cytokines
TNF
Interleukine
Cytokines IL-2
Tasks
From
T Cell
Growth
TH1
IL-3
Hematopoeitic
TH1
IL-4
T CellB Cell
Growth GrowthGrowth (IgG1, IgE, MHC II ↑)
IL-5
--
IL-10
T Cell
Inhibit TH1
IL-17
Hematopoeitic
Stimulates Neutrophils
TNF-
M
NO Production (Against Gram -)
TH1
TNF-
M
NO Production (Lymph Node growth)
TH1
Tc
IFN-
M
Activation of MHCI, II
TH1
Tc
TGF-
M, T, Somatic
Inhibit Growth
Hematopoeitic
Increase Myeloid Growth
GM-GSF By 10001085
TH2
Tc
TH2 TH2 TH2
TH-REG TH17
TH2
Tc
TH-REG TH1
TH2
Tc
By 10001085