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免疫學 Immunology T Cell Activation Signals Signal 1: Activation - MHC, CD4, TCR Signal 2: Survival - Co-stimulator:  Survival Signal: CD28 ←→ B7.1, B7,2 (CD 80, CD 86)  Death Signal: CTLA4 ←→ B7(競爭) Signal 3: Differentiation - Cytokines Cells

Antigen

Inducer

Treg

Factor

Secretion

Target

TGF-

FoxP3

TGF-, IL-10 抑制 CD4 Cells

TFH

All Type

IL-6

Bcl6

IL-21, ICOS

B Cell Class Switch, IgG

TH17

發炎、細菌感染、自體免疫

TGF-IL-6

RORT

IL-6, IL-17

誘導 Fibroblast, Epi. Cell 分泌激素→吸引 Neutrophils

TH1

胞外細菌(Mycobacteria)感染

IL-12, INF-

T-bet

IL-2, INF-

增加 Macrophage Lysosome, Activation (CD40+ ligand)

TH2

寄生蟲、過敏(氣喘)

GATA3

IL-4 IL-5 IL-13

吸引 B Cell,以抗體誘發 Mast Cell (Via FcRI) 吸引顆粒球 吸引 Eosinophils

T Cell

Cytokines

TH1

IL-2

TH2

IL-4

Effector T Cell 生長因子

B Cell 生長因子,J Chain Synthesis

Macrophage

Hematopoeitic

--

--

IFN-

與 TH2 產生拮抗

IgG2a Synthesis

增加 MHCI, II 活性

--

TNF-

殺死 T Cell

抑制 B Cell

活化,促進 NO 及 ROS

--

IL-4

生長因子

生長,IgG1, IgE

--

活化 Mast Cell (Via IgE)

IL-5

--

--

--

活化 Eosinophil

IL-10

與 TH1 產生拮抗

--

--

活化 Mast Cell

Immunity CellMediated

Humoral Immunity

By 10001085

T cell activation signals  
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