Public Health Practice Questions
Course Introduction
Public Health is an interdisciplinary field focused on protecting and improving the health of populations through disease prevention, health promotion, and policy interventions. This course explores the foundations of public health, including its history, core functions, and essential services. Students will examine major public health challenges, such as infectious diseases, chronic illnesses, environmental health hazards, and health disparities. Emphasizing a population-based approach, the course also covers the roles of epidemiology, biostatistics, health policy, and community engagement in developing effective public health strategies. By the end of the course, students will gain a broad understanding of public health principles and their application to real-world issues, preparing them for further study and practice in diverse health-related fields.
Recommended Textbook
Basic Immunology Functions and Disorders of the Immune System 4th Edition by Abul K. Abbas
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12 Chapters
181 Verified Questions
181 Flashcards
Source URL: https://quizplus.com/study-set/1165 Page 2
Chapter 1: Introduction to the Immune System
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16 Verified Questions
16 Flashcards
Source URL: https://quizplus.com/quiz/23007
Sample Questions
Q1) A standard treatment of animal bite victims, when there is a possibility that the animal was infected with the rabies virus, is administration of human immunoglobulin preparations containing anti-rabies virus antibodies. Which type of immunity would be established by this treatment?
A)Active humoral immunity
B)Passive humoral immunity
C)Active cell-mediated immunity
D)Passive cell-mediated immunity
E)Innate immunity
Answer: B
Q2) Which of the following infectious diseases was prevented by the first successful vaccination?
A)Polio
B)Tuberculosis
C)Smallpox
D)Tetanus
E)Rubella
Answer: C
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Chapter 2: Innate Immunity
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23008
Sample Questions
Q1) Which of the following is an example of how the innate immune response stimulates or modifies adaptive immunity?
A)Tumor necrosis factor (TNF) secreted by helper T cells enhances adhesion molecules on endothelial cells and promotes recruitment of inflammatory cells.
B)Interferon (IFN)- produced by T helper cells is a potent activator of macrophages, allowing killing of phagocytosed microbes.
C)B7-1 expression on antigen-presenting cells is up-regulated in response to signaling through Toll-like receptors, thus enabling costimulation of T cells.
D)Infected cells coated by IgG3 are recognized by Fc receptors on natural killer cells, allowing efficient killing of the infected cells.
E)Double-stranded RNA of replicating viruses potently stimulates IFN- expression by fibroblasts, inducing an "antiviral state" in neighboring, uninfected cells.
Answer: C
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Chapter 3: Antigen Capture and Presentation to Lymphocytes
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23009
Sample Questions
Q1) A child who suffers from a persistent viral infection is found to have a deficiency in lymphocyte production and very few T and B cells. Other bone marrow-derived cells are produced in normal numbers, and MHC molecule expression on cells appears normal. Transfusion of mature T cells from an unrelated donor who had recovered from a previous infection by the same virus would not be expected to help the child clear his infection. Which one of the following is a reasonable explanation for why this therapeutic approach would fail?
A)Viral infections are cleared by antibodies, not T cells.
B)The patient's own immune system would destroy the transfused T cells before they could respond to the viral infection.
C)T cells recognize peptides, not viral particles.
D)Donor T cell viral antigen recognition is restricted by MHC molecules not expressed in the patient.
E)In responding to the previous infection, the donor would have used up all his T cells specific for that virus.
Answer: D
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Page 5
Chapter 4: Antigen Recognition in the Adaptive Immune System
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23010
Sample Questions
Q1) The T cell receptor (TCR) complex differs from an immunoglobulin molecule in which one of the following ways?
A)On average, a TCR binds antigen with much lower affinity than does an Ig molecule.
B)The TCR can serve as a lymphocyte antigen receptor, but an Ig molecule cannot.
C)Only the TCR can bind soluble antigen directly.
D)The TCRs expressed by one clone of T cells can undergo changes in constant region structure after cellular activation, whereas Ig molecules expressed by one clone of B cells do not.
E)The TCR polypeptide chains have short cytoplasmic tails and rely on associated proteins for signaling functions, whereas membrane Ig receptors are competent signaling molecules on their own.
Q2) CD1-restricted T cells differ from other T cells restricted to class I or class II MHC molecules in which one of the following ways?
A)CD-1 restricted T cells cannot rapidly secrete cytokines.
B)CD-1 restricted T cells recognize non-peptide antigens, such as lipids.
C)CD-1 restricted T cells bind both cell-associated and soluble antigens.
D)CD-1 restricted T cells express both CD4 and CD8 coreceptors.
E)CD-1 restricted T cells are actually natural killer (NK) cells.
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Chapter 5: T Cell Mediated Immunity
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15 Verified Questions
15 Flashcards
Source URL: https://quizplus.com/quiz/23011
Sample Questions
Q1) Which one of the following statements about the molecule Lck is NOT true?
A)It is a member of the Src family of kinases.
B)It binds to the cytoplasmic tails of T cell coreceptors CD4 or CD8.
C)It phosphorylates ITAM motifs on the CD3 complex.
D)It phosphorylates tyrosine residues on Zap-70 and activates it.
E)It phosphorylates PIP2 to PIP3 and leads to the activation of Itk.
Q2) Which one of the following cell types would be most potent at activating naive T cells?
A)Kupffer cells
B)B cells
C)Follicular dendritic cells
D)Neutrophils
E)Langerhans cells
Q3) All of the following molecules act as transcription factors in T cell activation signaling EXCEPT:
A)NF- B
B)Jun
C)Fos
D)NFAT
E)Ras
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Chapter 6: Effector Mechanisms of T Cell Mediated Immunity
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23012
Sample Questions
Q1) The induction phase of a cell-mediated immune response includes which of the following events?
A)CD4 T cell secretion of interferon- leading to macrophage activation
B)CD8 T cell lysis of a virally infected cell
C)Clonal expansion of CD8 T cells within a lymph node
D)Migration of CD4 effector T cells from blood vessels into a tissue site of infection
E)Migration of a naive CD4 T cell from the thymic medulla into the circulation
Q2) Differentiation of TH2 cells from naive precursor cells is dependent on which of the following?
A)Toll-like receptor (TLR) ligands
B)T-bet
C)Interleukin-12
D)GATA-3
E)Interferon-
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8
Chapter 7: Humoral Immune Responses
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23013
Sample Questions
Q1) Which one of the following statements about primary and secondary antibody responses is NOT true?
A)Antibodies in primary responses generally have lower affinity for antigen than those produced in secondary responses.
B)Secondary responses reach peak levels more quickly than primary responses.
C)Primary responses require higher concentrations of antigen for initiation than secondary responses.
D)Primary responses occur to all types of antigens, but secondary responses mostly occur only to protein antigens.
E)Primary responses are characterized by IgG antibodies, whereas secondary responses are dominated by IgM antibodies.
Q2) All of the following assays are used to detect antibody production EXCEPT:
A)BrdU (bromodeoxyuridine) assay
B)Enzyme-linked immunosorbent assay (ELISA)
C)ELISPOT assay
D)Hemolytic plaque assay
E)Radioimmunoassay (RIA)
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Chapter 8: Effector Mechanisms of Humoral Immunity
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13 Verified Questions
13 Flashcards
Source URL: https://quizplus.com/quiz/23014
Sample Questions
Q1) A 17-year-old boy is taken to the emergency department because of severe abdominal and lumbar pain. Physical examination reveals splenomegaly, and laboratory studies reveal hemoglobinemia and thrombocytopenia. A urine sample is remarkable for gross hemoglobinuria. The patient reports a history of bloody urine on multiple occasions in the past. Flow cytometric analysis of the patient's red blood cells (RBC) will most likely indicate reduced or absent expression of which pair of molecules that is normally present on RBC membranes?
A)Complement receptor 1 (CR1) and CR2
B)C1 inhibitor (C1 INH) and membrane cofactor protein (MCP, CD46)
C)Decay accelerating factor (DAF, CD55) and CD59
D)C4 binding protein (C4bp) and factor H
E)Complement receptor 3(CR3) and complement receptor 4(CR4)
Q2) Which of the following is NOT a property of the classical pathway C3 convertase?
A)Composed of proteolytic fragments of C4 and C2
B)Has protease activity specific for C3 to form C3b
C)Inhibited by decay acceleration factor (DAF)
D)Stabilized by C4 binding protein (C4bp)
E)Same substrate specificity as the alternative pathway C3 convertase
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Chapter 9: Immunological Tolerance and Autoimmunity
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17 Verified Questions
17 Flashcards
Source URL: https://quizplus.com/quiz/23015
Sample Questions
Q1) Many tumors are found to overexpress bcl-2, which favors survival of the transformed cells. Which of the following best describes the function of bcl-2?
A)Direct inhibition of caspase-8
B)Direct inhibition of caspase-9
C)Up-regulates expression of DNA repair enzymes
D)Reduces the leakiness of the mitochondrial membrane
E)Inhibits the activity of granzymes released from cytotoxic T lymphocytes
Q2) A genetic deficiency in the ability to produce which of the following molecules results in autoimmunity?
A)B7-1
B)CD28
C)CD40L
D)Interferon-
E)Interleukin-2
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Chapter 10: Immune Responses against Tumors and Transplants
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10 Verified Questions
10 Flashcards
Source URL: https://quizplus.com/quiz/23016
Sample Questions
Q1) Patients with which of the following disorders would be LEAST likely to develop Epstein-Barr virus-associated Burkitt's lymphoma?
A)AIDS
B)Bruton's disease
C)DiGeorge syndrome (congenital absence of the thymus)
D)Malarial infection
E)Immunosuppressive therapy for renal allograft
Q2) The first experiments that demonstrated protective adaptive immune responses to tumors involved transplantation of chemical carcinogen-induced tumors between rodents. Which of the following facts was learned from these experiments?
A)There are only a limited number of antigens that can evoke a protective anti-tumor response.
B)Transplanted sarcomas can evoke protective cytolytic T lymphocyte responses.
C)Carcinomas express tumor antigens that are recognized by T lymphocytes.
D)Protective immune responses against tumors are largely mediated by antibodies.
E)Spontaneously arising tumors are often eradicated by cytolytic T lymphocytes.
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12
Chapter 11: Hypersensitivity
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14 Verified Questions
14 Flashcards
Source URL: https://quizplus.com/quiz/23017
Sample Questions
Q1) An 8-year-old boy from the intermountain region of the United States is brought to the pediatrician with fever, rash, and pain in his knees and ankles. Pericarditis is evident on auscultation, and echocardiography confirms mitral valve regurgitation. Three weeks before this episode, the patient had experienced a sore throat but had not received medical attention. High titers of antistreptococcal antibodies are present in the serum. This child's disease is a result of which one of the following phenomena?
A)Clonal anergy
B)Peripheral tolerance
C)Epitope spreading
D)Central tolerance
E)Molecular mimicry
Q2) All of the following are effector mechanisms of antibody-mediated disease EXCEPT:
A)Opsonization and phagocytosis of cells
B)Fas-dependent apoptosis of cells
C)Complement- and Fc receptor-mediated inflammation and tissue injury
D)Antibody stimulation of cell surface receptors in the absence of the physiologic ligands
E)Fc R crosslinking
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Page 13
Chapter 12: Congenital and Acquired Immunodeficiencies
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18 Verified Questions
18 Flashcards
Source URL: https://quizplus.com/quiz/23018
Sample Questions
Q1) Which one of the following is typically NOT associated with T cell immunodeficiencies?
A)Cancer
B)Viral infection
C)Autoimmunity
D)Infection with intracellular microbes
E)Infection with pyogenic bacteria
Q2) A 7-month-old boy is evaluated in the clinic for recurrent bacterial infections. His tonsils are not visible on physical examination. Serum immunoglobulin A (IgA) and IgG levels are markedly decreased, and serum IgM levels are slightly below normal. The gene identified in this patient plays a critical role in receptor binding to all of the following ligands EXCEPT:
A)Interleukin (IL)-2
B)IL-4
C)IL-7
D)IL-12
E)IL-15
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