Social inequality is at the heart of the 2030 Agenda for Sustainable Development. For Latin America —the world’s most unequal region— social inequality also represents a structural feature and therefore a fundamental challenge. In response to the mandate conferred upon the Economic Commission for Latin America and the Caribbean (ECLAC) by the countries at the Regional Conference on Social Development in Latin America and the Caribbean, held in Lima in November 2015, this document pursues the analysis of the social inequality matrix in the region. The analysis focuses on some of the main axes that serve to structure social inequality (gender, ethnicity, race, age or stage of the life cycle, and territory) in order to illustrate how they influence the depth of the equality gaps, their persistence over time and their reproduction.