This e-book has developed based on a series of lectures notes used in the Embedded System Applications course in the Electrical Engineering Department, Polytechnic Sultan Haji Ahmad Shah (POLISAS). It contains eight chapters that parallel the syllabus of Embedded System Applications for Diploma of Electrical/Electronic Engineering in Polytechnics curriculum. This book covers the basic concept and application of a microcontroller system based on Peripheral Interface Controller (PIC) microcontroller. Students will learn software and hardware development on the PIC18F4550 microcontroller and understand how to do interface with external devices using suitable internal chip features. The variety of examples and review questions in this book may help students to have a better understanding of Embedded System Application using PIC18F4550.