ECE NEWS WINTER 2022
ELECTRICAL & COMPUTER ENGINEERING
A Computational Look at How Genes Change the Human Brain
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ssistant Professor Liang Zhan received a $500,000 CAREER award from the National Science Foundation to develop computational tools that improve our understanding of the human brain.
In this project, he will leverage brain modular structure to study brain imaging genetics and develop new computational tools to illuminate how genetic factors impact brain structure and function. Researchers can use this technology to examine how specific genes, or their variants, affect neural systems and contribute to brain disorders. Zhan’s team will specifically study Alzheimer’s disease – a condition that currently affects 5.8 million Americans and is projected to nearly triple to 14 million people by 2060. “There is no clear evidence to show how Alzheimer’s disease develops,” said Zhan. “Researchers are developing a variety of methods to uncover the mechanisms behind Alzheimer’s onset and progression, but we lack effective computational tools.” Though this work focuses on Alzheimer’s disease, the proposed tools can be applied to other brain research as well. “Current brain imaging genetics studies assume a one-to-one linear relationship between genes and imaging features, but linearity is too simplistic and does not allow researchers to identify high-level patterns,” explained Zhan. “Additionally, MRI research often focuses on small regions of the brain, which reduces the complexity of the imaging down to one-dimension and discards important information on brain dynamics. Instead, my group will focus on characterizing higher-level brain network features.”
2021 NSF CAREER Award Winner
Annual Publication of the University of Pittsburgh Swanson School of Engineering
Synthesizing an Artificial Synapse for Artificial Intelligence
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n science fiction stories from “I, Robot” to “Star Trek,” an android’s “positronic brain” enables it to function like a human, but with tremendously more processing power and speed. In reality, the opposite is true: a human brain – which today is still more proficient than CPUs at cognitive tasks like pattern recognition – 2020 NSF CAREER Award Winner needs only 20 watts of power to complete a task, while a supercomputer requires more than 50,000 times that amount of energy. For that reason, researchers are turning to neuromorphic computers and artificial neural networks that work more like the human brain. However, with current technology, it is both challenging and expensive to replicate the spatio-temporal processes native to the brain, like short-term and long-term memory, in artificial spiking neural networks (SNN). Feng Xiong, assistant professor, received a $500,000 CAREER Award from the National Science Foundation for his work developing the missing element, a dynamic synapse, that will dramatically improve energy efficiency, bandwidth and cognitive capabilities of SNNs.
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engineering.pitt.edu/ece