Supplements Urolithin A Reviews: Definition, Mechanism, Benefits & Side Effects

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Supplements Urolithin A Reviews: Definition, Mechanism, Benefits & Side Effects What is Urolithin A? Urolithin A is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria. It belongs to the class of organic compounds known as benzo-coumarins or dibenzo-α-pyrones. Urolithin A has been demonstrated to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging. Meanwhile, it also has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer’s Disease.

Urolithin A powder is a natural product with antiproliferative and antioxidant activity.

Urolithin A is formed by metabolism from polyphenols found in some nuts and fruits, particularly pomegranates. Its precursors – ellagic acids and ellagitannins – are ubiquitous in nature, including edible plants, such as pomegranates, strawberries, raspberries, walnuts, tea and muscat grapes, as well as many tropical fruits.

Since the 2000s, urolithin A has been subject of preliminary studies regarding its possible biological effects.

Urolithin A（1143-70-0）Specifications

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How does Urolithin A work?

Urolithin A is urolithin, a microbial human metabolite of dietary ellagic acid derivatives (such as ellagic acid). In the intestinal metabolism of bacteria, ellagitannin and ellagic acid lead to the formation Active urolithins A, B, C and D. Among them, urolithin A (UA) is the most active and effective intestinal metabolite, which can be used as an effective anti-inflammatory and antioxidant.

In laboratory studies, it has been shown that urolithin A induces mitochondria, which is the selective recovery of mitochondria through autophagy. Autophagy is a process of removing defective mitochondria after injury or stress, and is efficient during aging. lower and lower. This effect has been observed in different animal species

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(mammalian cells, rodents and Caenorhabditis elegans).

However, because the source of ellagitannin is different, the composition of each bacterial group will also be different, so the efficiency of conversion to urolithin A is very different in humans, and some people may not have any conversion.

Urolithin A benefits Urolithin A (UA) is a natural diet, a metabolite derived from the microbial community.

It has a variety of health benefits, including reducing inflammatory signaling, anti-cancer effects and inhibiting lipid accumulation.

As the most active and effective intestinal metabolite, urolithin A (UA) can act as an effective anti-inflammatory and antioxidant. It can also stimulate mitochondrial phagocytosis in older animals and preclinical models of aging and improve muscle health.

Can the Urolithin A be used as supplements?

In 2018, the US Food and Drug Administration classified urolithin A as a safe ingredient in food or dietary supplement products, with amounts ranging from 250 milligrams to 1 gram per serving.

Is there any side effects of Urolithin A? Safety studies in older adults have shown that urolithin A is well tolerated. In vivo studies have not determined whether there are any toxicity or specific adverse effects 3

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of dietary urolitin A intake.

Also, long-term safety for supplementation of Urolithin A and pomegranate is not known, though short-term treatment with pomegranate extract is safe.

Reference: [1] Garcia-Muñoz, Cristina; Vaillant, Fabrice (2014-12-02). “Metabolic Fate of Ellagitannins: Implications for Health, and Research Perspectives for Innovative Functional Foods”. Critical Reviews in Food Science and Nutrition. 54 (12): 1584–1598. doi:10.1080/10408398.2011.644643. ISSN 1040-8398. PMID 24580560. S2CID 5387712.

[2] Ryu, D. et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat. Med. 22, 879–888 (2016).

[3] “FDA GRAS notice GRN No. 791: urolithin A”. US Food and Drug Administration. 20 December 2018. Retrieved 25 August 2020.

[4] Singh, A.; Andreux, P.; Blanco-Bose, W.; Ryu, D.; Aebischer, P.; Auwerx, J.; Rinsch, C. (2017-07-01). “Orally administered urolithin A is safe and modulates muscle and mitochondrial biomarkers in elderly”. Innovation in Aging. 1 (suppl_1): 1223– [5] Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose, William (2017). “Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid”. Food and Chemical Toxicology. 108 (Pt A): 289– doi:10.1016/j.fct.2017.07.050.

PMID 28757461.

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