RETIREMENTS Effective June 30, 2015, Dr. Sheri Adams, Professor, Dept. of Biochemistry, retired from the School’s standing faculty, becoming Professor Emeritus. Dr. Adams was a valued member of the School’s faculty for 36 years and was also serving as Director of Faculty Advancement and Diversity upon her retirement.
ENDODONTICS
Hajishengallis G, Maekawa T, Abe T, Hajishengallis E, Lambris JD (co-author in Division of Pediatric Dentistry). Complement involvement in periodontitis: Molecular mechanisms and rational therapeutic approaches. Adv Exp Med Biol. 2015;865: 57–74. DOI:10.1007/978–3–319–186030_4.
SELECTED PUBLICATIONS Recently published work by department researchers (indicated in bold). Boesze-Battaglia K, Walker LP, Zekavat A, Dlakic M, Scuron MD, Nygren P, Shenker BJ. (co-author in Dept. of Pathology) The aggregatibacter actinomycetemcomitans cytolethal distending toxin active subunit, CdtB, contains a c sequence required for toxin binding and subunit internalization. Infect Immun. 2015 Jul 27. DOI:IAI.00788–15. Daniell H, Stewart CN,Jr, Zhang B. Discoveries and advances in noncoding RNAs. Plant Biotechnol J. 2015 Apr;13(3):281. DOI:10.1111/pbi.12375. Jin S, Singh ND, Li L, Zhang X, Daniell H. Engineered chloroplast dsRNA silences cytochrome p450 monooxygenase, V-ATPase and chitin synthase genes in the insect gut and disrupts helicoverpa armigera larval development and pupation. Plant Biotechnol J. 2015 Apr;13(3):435–46. DOI:10.1111/pbi.12355. Kwon KC, Daniell H. Low-cost oral delivery of protein drugs bioencapsulated in plant cells. Plant Biotechnol J. 2015 Sep 3. DOI:10.1111/pbi.12462. Lin CS, Chen JJ, Huang YT, Chan MT, Daniell H, Chang WJ, Hsu CT, Liao DC, Wu FH, Lin SY, Liao CF, Deyholos MK, Wong GK, Albert VA, Chou ML, Chen CY, Shih MC. The location and translocation of ndh genes of chloroplast origin in the orchidaceae family. Sci Rep. 2015 Mar 12;5:9040. DOI:10.1038/srep09040. Su J, Sherman A, Doerfler PA, Byrne BJ, Herzog RW, Daniell H. Oral delivery of acid alpha glucosidase epitopes expressed in plant chloroplasts suppresses antibody formation in treatment of pompe mice. Plant Biotechnol J. 2015. DOI:10.1111/pbi.12413. Su J, Zhu L, Sherman A, Wang X, Lin S, Kamesh A, Norikane JH, Streatfield SJ, Herzog RW, Daniell H. Low cost industrial production of coagulation factor IX bioencapsulated in lettuce cells for oral tolerance induction in hemophilia B. Biomaterials. 2015 Aug 5;70:84–93. DOI:S0142–9612(15)00656–0.
El-Kassas S, Faraj R, Martin K, Hajishengallis G, Connell TD, Nashar T. Cell clustering and delay/arrest in T-cell division implicate a novel mechanism of immune modulation by E. coli heat-labile enterotoxin B-subunits. Cell Immunol. 2015 Jun;295(2):150–62. DOI:10.1016/j. cellimm.2015.02.014.
NEWS/ACHIEVEMENTS Dr. Yi-Tai Jou, Director of the Predoctoral Endodontic Program, received the Robert E. DeRevere Award from the Penn Dental Medicine Class of 2015, presented for excellence in preclinical teaching by a part-time faculty member.
MICROBIOLOGY RECENT GRANT AWARDS Functions of HSV Glycoproteins in Virus Entry and the Humoral Immune Response Sponsor: NIAID/NIH/DHHS Principal Investigator: Dr. Gary Cohen, Professor, Dept. of Microbiology
SELECTED PUBLICATIONS Recently published work by department researchers (indicated in bold). Abe T, AlSarhan M, Benakanakere MR, Maekawa T, Kinane DF, Cancro MP, Korostoff JM, Hajishengallis G. (co-authors in the Dept. of Periodontics) The B cell-stimulatory cytokines BLyS and APRIL are elevated in human periodontitis and are required for B cell-dependent bone loss in experimental murine periodontitis. J Immunol. 2015 Aug 15;195(4):1427–35. DOI:10.4049/jimmunol.1500496. Cairns TM, Huang ZY, Gallagher JR, Lin Y, Lou H, Whitbeck JC, Wald A, Cohen GH, Eisenberg RJ. Patient-specific neutralizing antibody responses to herpes simplex virus are attributed to epitopes on either gD, gB, or both and can be type-specific. J Virol. 2015 Jun 24. DOI:JVI.01213–15. Duan X, Gleason RC, Li F, Hosur KB, Duan X, Huang D, Wang H, Hajishengallis G, Liang S. Sex dimorphism in periodontitis in animal models. J Periodontal Res. 2015 Jul 22. DOI:10.1111/jre.12298.
ORAL MEDICINE NEWS/ACHIEVEMENTS Dental Clinics of North America Clinical Approaches to Oral Mucosal Disorders: Part II (Elsevier), edited by Dr. Thomas Sollecito (D’89, GD’91), Chair and Professor of Oral Medicine, and Dr. Eric Stoopler (D’99, GD’02), Associate Professor of Oral Medicine, received the International College of Dentists Special Citation Journalism Award for its concept and presentation, presented at the Annual Meeting of the American Association of Dental Editors & Journalists, November 2015.
Kim PD, Xia-Juan X, Crump KE, Abe T, Hajishengallis G, Sahingur SE. Toll-like receptor 9-mediated inflammation triggers alveolar bone loss in experimental murine periodontitis. Infect Immun. 2015 Jul;83(7): 2992-3002. DOI:10.1128/IAI.00424-15. Mastellos DC, Ricklin D, Hajishengallis E, Hajishengallis G, Lambris JD (co-author in Division of Pediatric Dentistry). Complement therapeutics in inflammatory diseases: Promising drug candidates for C3targeted intervention. Mol Oral Microbiol. 2015 Aug 29. DOI:10.1111/omi.12129. Moutsopoulos NM, Lionakis MS, Hajishengallis G. Inborn errors in immunity: Unique natural models to dissect oral immunity. J Dent Res. 2015 Jun;94(6):7538. DOI:10.1177/0022034515583533. Saw WT, Matsuda Z, Eisenberg RJ, Cohen GH, Atanasiu D. Using a split luciferase assay (SLA) to measure the kinetics of cell-cell fusion mediated by herpes simplex virus glycoproteins. Methods. 2015. DOI:10.1016/j.ymeth.2015.05.021. Schormann N, Banerjee S, Ricciardi R, Chattopadhyay D. Binding of undamaged double stranded DNA to vaccinia virus uracilDNA glycosylase. BMC Struct Biol. 2015; 15(1). DOI:10.1186/s12900–015–0037–1. Wu T, Wang Q, Jiang C, Morris-Natschke SL, Cui H, Wang Y, Yan Y, Xu J, Lee K-, Gu Q. Neo -clerodane diterpenoids from scutellaria barbata with activity against epstein-barr virus lytic replication. J Nat Prod. 2015;78(3):500–9. DOI:10.1021/ np500988m. Zenobia C, Hajishengallis G. Basic biology and role of interleukin-17 in immunity and inflammation. Periodontol 2000. 2015 Oct;69(1):142-59. DOI:10.1111/prd.12083.
Dr. Mel Mupparapu (D’96), Professor of Oral Medicine and Director of Radiology, received the Senior Outstanding Teaching Award from the Penn Dental Medicine Class of 2015, presented to a faculty member who has gone beyond the scope of his/her responsibilities to significantly impact the class’s education at Penn Dental Medicine. In addition, Dr. Mupparapu and two students conducting research projects with him — Ariel Farahi (D’16) and Sheldon Rozman (D’17) – represented Penn Dental Medicine at the XX International Conference of Dentomaxillofacial Radiology (ICDMFR), in Santiago, Chile, August 2015. Farahi’s project was “Evaluation of FDI and universal tooth numbering system usability among nonUS trained dental practitioners enrolled in an advanced standing DMD program” and Rozman’s was “Diagnosis of atlantoaxial subluxation using CBCT-based vertical atlantoaxial index, posterior odontoid angle and Power’s ratio analysis;” both students were invited to present at next year’s ICDMFR as well. Farahi and Dr. Mupparapu also presented an abstract at the 97th annual meeting of the American Academy of Oral & Maxillofacial Surgeons, October 2015.
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