Moore PA, Hersh EV. Combining ibuprofen and acetaminophen for acute pain management after third-molar extractions: Translating clinical research to dental practice. J Am Dent Assoc. 2013 Aug;144(8):898-908. Peacock ZS, Kademani D, Le AD, Lee JS, Hale RG, Cunningham Jr. LL. Proceedings from the 2011 American Association of Oral and Maxillofacial Surgeons research summit. J Oral Maxillofac Surg. 2012;70(6):1271-9. DOI:10.1016/j.joms.2012.01.029. Shi S, Zhang Q, Atsuta I, Liu S, Chen C, Shi S, Le AD. IL-17-mediated M1/M2 macrophage alteration contributes to pathogenesis of bisphosphonate-related osteonecrosis of the jaws. Clin Cancer Res. 2013;19(12):3176-88. DOI:10.1158/1078-0432.CCR-13-0042. Xu X, Chen C, Akiyama K, Chai Y, Le AD, Wang Z, Shi S. Gingivae contain neural-crest- and mesoderm-derived mesenchymal stem cells. J Dent Res. 2013;92(9):825-32. DOI:10.1177/0022034513497961. Zhang Q, Nguyen AL, Shi S, Hill C, Wilder-Smith P, Krasieva TB, Le AD. Three-dimensional spheroid culture of human gingiva-derived mesenchymal stem cells enhances mitigation of chemotherapy-induced oral mucositis. Stem Cells Dev. 2012;21(6):937-47. DOI:10.1089/scd.2011.0252.
ORTHODONTICS APPOINTMENTS Dr. Hyun (Michel) Koo has joined the standing faculty as Professor, Dept. of Orthodontics. He comes to Penn Dental Medicine from the University of Rochester School of Medicine and Dentistry (see story, page 2). Dr. Dr. Guy Coby (GD’87, GD’90), Clinical Associate Professor of Orthodontics, has been appointed CoDirector of the Orthodontic Clinic along with Dr. Peter M. Greco (D’79, GD’84), Clinical Professor of Orthodontics.
SELECTED PUBLICATIONS
PERIODONTICS
Recently published work by department researchers (indicated in bold).
AWARDS & ACHIEVEMENTS
Habeeb M, Boucher N, Chung CH. Effects of rapid palatal expansion on sagittal and vertical dimensions of the maxilla - a study on cephalograms derived from cone-beam computed tomography. American Journal of Orthodontics and Dentofacial Orthopedics 2013;144: 398403. Chung CH. Book review: OrthodonticsCurrent Principles and Techniques, 5th edition. American Journal of Orthodontics and Dentofacial Orthopedics, 2013;144:488.
PATHOLOGY PROMOTIONS Dr. Kelly Jordan-Sciutto has been promoted to Professor, Dept. of Pathology. Dr. Jordan-Sciutto has been a member of the School’s faculty since 2001 and was named Chair of the Department in 2012.
RECENT GRANT AWARDS See grants awards under Biochemistry of Dr. Henry Daniell, who has a joint appointment in the Dept. of Pathology.
SELECTED PUBLICATIONS Recently published work by department researchers (indicated in bold). Alawi F. Oral cancer screening. Penn Dent J (Phila). 2012 Fall:7. Alawi F. Pigmented lesions of the oral cavity. an update. Dent Clin North Am. 2013. DOI:10.1016/j.cden.2013.07.006. Alawi F. An update on granulomatous diseases of the oral tissues. Dent Clin North Am. 2013. DOI:10.1016/j.cden.2013.07.004. Brown AC, Balashova NV, Epand RM, Epand RF, Bragin A, Kachlany SC, Walters MJ, Du Y, Boesze-Battaglia K, Lally ET. (co-author in Dept. of Biochemistry) Aggregatibacter actinomycetemcomitans leukotoxin utilizes a cholesterol recognition/amino acid consensus site for membrane association. J Biol Chem. 2013;288(32):23607-21. DOI:10.1074/jbc.M113.486654.
The Dept. of Periodontics honored leaders in the field of periodontics and prosthodontics at a special reception held during the AAP 2013 meeting in Philadelphia. The honorees included: Drs. D. Walter Cohen (C’47, D’50), Morton Amsterdam (C’43, D’45), Jan Lindhe, Leonard Abrams, Jay Seibert (D’53), Robert Genco (GR’67), Max Listgarten, Jorgen Slots (D’86, WG’89), Herman Corn (GD’58), George Coslet (GD’67), Arnold Weisgold (GD’65), and David Garber (GD’78, D’81).
MANAGING MAST CELLS Human β-defensins (hBDs) are antimicrobial peptides that play an important role in host defense, but can also promote inflammatory diseases and tumor formation. Dr. Hydar Ali’s group provided the first demonstration hBDs activate human mast cells via a novel cell surface G-protein-coupled receptor, MrgX2, which is expressed only in human but not murine mast cells. Thus, while hBD3 caused mediator release in human mast cells, they had no effect on murine mast cells in vitro or in vivo. This work is potentially important for human mast cell-mediated diseases, such as asthma. See: Subramanian H, Gupta K, Lee D, Bayir AK, Ahn H, Ali H. ß-Defensins activate human mast cells via mas-related gene X2. J Immunol. 2013;191(1):345-52. DOI:10.4049/jimmunol.1300023.
Dr. Arnold Weisgold (GD’65), Adjunct Professor, Dept. of Periodontics, received the Leadership Award, presented by the Kornberg School of Dental Medicine, and the Distinguished Clinician’s Award, presented by Quintessence Publishing Co. and the International Journal of Periodontics and Restorative Dentistry at the 11th International Symposium of Periodontics and Restorative Dentistry.
SELECTED PUBLICATIONS Recently published work by department researchers (indicated in bold). Biyikoglu B, Buduneli N, Aksu K, Nalbantsoy A, Lappin DF, Evrenosoglu E, Kinane DF. Periodontal therapy in chronic periodontitis lowers gingival crevicular fluid interleukin-1beta and DAS28 in rheumatoid arthritis patients. Rheumatol Int. 2013:1-10. DOI:10.1007/s00296-013-2781-5. Buduneli N, Biyikoglu B, Ilgenli T, Buduneli E, Nalbantsoy A, Saraç F, Kinane DF. Is obesity a possible modifier of periodontal disease as a chronic inflammatory process? A case-control study. J Periodontal Res. 2013. DOI:10.1111/jre.12125. Chapple IL, Genco R, working group 2 of the joint EFP/AAP workshop. Working Group participant: Graves DT. Diabetes and periodontal diseases: Consensus report of the joint EFP/AAP workshop on periodontitis and systemic diseases. J Periodontol. 2013 Apr;84(4 Suppl):S106-12. DOI:10.1902/jop.2013.1340011.
Also see H Daniell under Biochemistry and D Kinane under Periodontics, both of whom have joint appointments in the Dept. of Pathology.
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