Curcuma gold, la curcuma bio-activada, altamente biodisponible by NUTRIPRAXIS

Low Bio-availability Of Conventional Turmeric Extract

Traditional use of turmeric – • Turmeric powder in culinary applications • Conventional turmeric extracts contain only Curcuminoids • Very low retention in blood

Chemical Composition Of Turmeric

CURCUMINOIDS

1 1

Curcuminoids

2-6%

Volatile oil

3-7%

Carbohydrates

60-70%

Moisture

6-13%

Fat

5-10%

Protein

6-8%

Mineral matter

3-7%

Fiber

2-7%

Desmethoxy curcumin Bis desmethoxy curcumin

VOLATILE OIL Turmerones Ar-turmerone

Most active ingredient in turmeric, but very poor in oral bio availability

POWER OF SYNERGY FOR ACTIVE CURCUMIN

Enhancing The Power Of Curcumin Through Synergism

Oral Bioavailability

BCM–95 is 6.93 times more bio-available than Curcumin

Human Crossover Study to evaluate Bio- availability of BCM–95, Indian journal of pharmaceutical sciences, July – August 2008, 445 - 449

Mechanism of enhanced curcumin bioavailability

P glycoprotein (Pgp)- an important protein of cell membrane , widely distributed in intestine

Function • Pumps xenobiotocs out of cells into intestinal lumen • leads to reduced absorption and low bioavailability Role of Pgp in curcumin absorption • Increase the outflow (efflux) of curcumin into intestinal lumen • Hence poor bioavailability How does turmerone help • Turmerones are inhibitors of Pgp • Prevent the efflux of curcumin back to intestine • Thereby increase the bioavailability of curcumin in body Conclusion • Curcumin is better bioavailable in presence of turmerones

Synergistic Effect Of Curcuminoids & Ar-Turmerone Curcumin + Turmerones, abolishes inflammation in colon carcinogenesis.

At the low dose, Turmerones markedly suppressed adenoma multiplicity by 73% Curcumin at both doses suppressed adenocarcinoma multiplicity by 63-69% Combination of Curcumin and Turmerone at both low/high doses abolished tumor formation

DMH : Dimethyl hydrazine; DSS: Detran sulfate sodium

Reference: Murakami et al, Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis. Biofactors. 2013;39(2):221-32.

Synergistic Effect Of Curcuminoids & Ar-Turmerone

Curcuminoids and sesquiterpenoids in turmeric suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. Results indicated that turmeric extract containing both curcuminoids and sesquiterpenoids was more strongly hypoglycemic than either curcuminoids or sesquiterpenoids. Blood glucose level in KK-Ay mice fed diet alone (Cont) or diet containing curcuminoids (C), Turmerones (T) or combination of C + T

Reference: Nishiyama et al, Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. J Agric Food Chem. 2005; 53 (4): 959-63.

Bio Availability Enhancement – How Other Brands Deliver

Curcumin + Piperine

Curcumin + Phosphatidyl Choline

Curcumin + Soy Lecithin

• Bloodstream retention for a very short time • Long- term health safety concerns

• Curcumin not detected • Only C glucuronide and sulfate

• Very low levels detected

Bio Availability Enhancement – Other Brands

Curcumin + Polyvinyl pyrrolidone (PVP)

• Contains upto 75% PVP - a synthetic binder allowed only 10% in supplement by FDA • Measured only C metabolite

Liquid Based Curcumin

• Low levels of curcumin and very high levels of emulsifier • Studies conducted on liquid product and capsules ( powder)

Nano Curcumin

• Long term health safety concerns

Nano Curcumin

• Combination of curcumin with vanillin, sustained release, etc. • No scientific proof, unrealistic claims

Story Of The Worldâ&#x20AC;&#x2122;s Only 100% Turmeric Extract With Superior Bio-activity

Total Clinical Studies - 18 Total Granted Patents - 16 Total Publications

- 42

Total Ongoing Patents Countries Present

- 14 - 50

BCM-95 patent claim overview 1

US7736679

Composition

US 7879373

Process

US8153172

Method of preparation of gelatin capsule

US 7883728

Composition

US 8197869

Process

US 8329233

Process

US 8895087

Composition + Process

JP 5039032

Composition

JP 5511895

Composition

US8623431

Product by process

US8993013

Product by process

US 8859020

Application

US9492402

Product by process + Application

US 9878040

Composition + Process

US 9861677

Physiological claim

EP 2555787

Application

Story Of The World’s Only 100% Turmeric Extract With Superior Bio-activity

Salient Features • Enhanced bioavailability and retention in blood • High bioactivity at lower doses • 100% turmeric composition • Safety proven by detailed toxicity study • Produced using only clean solar energy

• GRAS Affirmed • Halal and Kosher Certified • GMP Certified • ISO 22000 Certified •Conforms to California’s Proposition 65 stringent standards on heavy metals

Story Of The World’s Only 100% Turmeric Extract With Superior Bio-activity Complies to • BAP and PAH4 limit as per new EU regulation EC/1933/2015. • Acceptable intake of residual solvents guideline set BY EU where Class 3 solvents are used which is considered to be Solvents with low toxic potential. • Regulation (EC) No 396/2005 of the European Parliament and of the Council of 23 February 2005 on maximum residue levels of pesticides • Regulation (EC) No 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants such as Heavy Metals (lead, cadmium, mercury, tin) in food ingredients. • Adheres to EU regulation on maximum level of Aflatoxins in food ingredients.

ALZHEMER’S DISEASE

NEUROLOGICAL DISEASES

General Dosage • 500 mg twice daily

CANCER

DIBATES

AUTO IMMUNE DISEASES

DEPRESSION

PULMONARY ANG GIT DESEASE

ARTHRITIS

STUDY 1

Effect of citrus polyphenol- and curcumin-supplemented diet oninflammatory state in obese cats. British Journal of Nutrition (2011), 106, S198–S201.

Animal Study

• Citrus and curcumin supplementation lower plasma APP (Acute-phase protein)levels. • An inflammatory state in obese cats that could be improved by dietary citrus and curcumin supplementation, especially through an action targeted on the liver.

STUDY 2

A Randomized, Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis PHYTOTHERAPY RESEARCH Phytother. Res. (2012). Baylor University Medical Center.

Human Study

Effective for the management of rheumatoid arthritis.

STUDY 3

Synergistic and Additive Effects of Modified Citrus Pectin With Two olybotanical Compounds, in the Suppression of Invasive Behavior of Human Breast and Prostate Cancer Cells.

Invitro

• Combination of PectaSol-C modified citrus pectin with BreastDefendor ProstaCaid synergistically inhibits adhesion of breast or prostate cancer cells.

Integrative Cancer Therapies 12(2) 145– 152.

• BreastDefend contains turmeric extract (BCM 95).

Indiana University Health, Indianapolis.

• ProstaCaid contains turmeric extract (BCM 95).

STUDY 4

A Pilot Clinical Trial of Radioprotective Effects of Curcumin Supplementation in Patients with Prostate Cancer J Cancer SciTher 2013, 5.10 National Nutrition and Food Technology Research Institute, Iran.

HCT

Curcumin can confer radioprotective effect in patients with prostate cancer who undergo radiation therapy through reducing the severity of radiotherapy related urinary symptoms.

STUDY 5

Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis. MOLECULAR MEDICINE REPORTS 8: 1542-1548, 2013. Anugraha Medical Centre, Kakkanad.

HCT

The formulation containing Curcuma longa and Boswellia serrata extracts (CB formulation) was evaluated for safety and efficacy in osteoarthritic patients. CB formulation emonstrated a greater improvement in the treatÂŹment of OA than celecoxib in the scores for pain, walking distance and joint line tenderness. The CB formulation was equally as effective as celecoxib in alleviating crepitus, and increasing the range of joint movements.

STUDY 6

Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial. PHYTOTHERAPY RESEARCH Phytother. Res. (2013). Baylor University Medical Center, Dallas.

HCT

This study provides first clinical evidence that curcumin may be used as an effective and safe modality for treatment in patients with Major Depressive Disorder without concurrent suicidal ideation or other psychotic disorders.

STUDY 7

Curcumin for the treatment of major depression: A randomised, doubleblind, placebo controlled study. Journal ofAffectiveDisorders167(2014)368– 375. MurdochUniversity,Perth, Western Australia.

HCT

• Enhanced antidepressant and anxiolytic efficacy of curcuminin in atypical depression characterized by mood reactivity to actual or potential positive events and two or more of the following features: • Significant weight gain or increased appetite. • Hypersomnia ,leaden paralysis. • A long-standing pattern of interpersonal rejection sensitivity.

STUDY 7

Curcumin for the treatment of major depression: A randomised, doubleblind, placebo controlled study. Journal ofAffectiveDisorders167(2014)368– 375. MurdochUniversity,Perth, Western Australia.

HCT

• Compared to healthy individuals, and people with melancholic or non-atypical depression, atypical depression is often associated with higher levels of inflammatory markers such as C-reactive protein(CRP). • Due to the anti- inflammatory effects of curcumin, it is this immuno-inflammatory dysregulation that may account for the increased efficacy of curcuminin in atypical depression.

STUDY 8

Curcumin Suppresses Crosstalk between Colon Cancer Stem Cells and Stromal Fibroblasts in the Tumor Microenvironment: Potential Role of EMT. PLoS ONE 9(9): e107514. doi: 10.1371/journal.pone.0107514. Ludwig-Maximilian-University Munich.

Invitro

Enrichment of cancer stem cells, the remarkable activation of tumor-promoting factors and epithelial-to- mesenchymal transition (EMT)[The epithelialâ&#x20AC;&#x201C; mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell-cell adhesion, and gain migratory and invasive properties to become mesenchymal stem cells]. in high density co-culture highlights that the crosstalk in the tumor microenvironment (cellular

STUDY 8

Curcumin Chemosensitizes 5Fluorouracil Resistant MMRDeficient Human Colon CancerCells in High Density Cultures. PLoS ONE 9(1): e85397. doi: 10.1371/journal.pone.0085397. Ludwig-Maximilian-University Munich.

Invitro

â&#x20AC;˘ Curcumin individually or in combination with the conventional colon cancer chemotherapeutic agent could serve as an effective therapeutic strategy to prevent the emergence of chemo resistant colon cancer cells by reducing cancer stem cells. â&#x20AC;˘ Reduced toxicity when using toxic chemotherapeutic drugs.

STUDY 9

Invitro

environment in which the tumor exists,) plays an essential role in tumor development and progression, and this interaction appears to be mediated at least in part by transforming growth factor-Î˛ (TGF-Î˛)that control cell growth, cell proliferationand EMT. Modulation of this synergistic crosstalk by curcumin might be a potential therapy forcolorectal cancer (CRC) and suppress metastasis.

STUDY 9

Invitro

â&#x20AC;˘ Combination treatment of phytochemicals together with conventional chemotherapeutic agents can be very beneficial for the patients in enhancing the clinical therapy and simultaneously reducing side effects through lower dosage requirements.

STUDY 10

Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer. BMC Cancer (2015) 15:250. Ludwig-Maximilian-University Munich.

â&#x20AC;˘ Curcumin sensitizes CRC cells to 5-fluorouracil (5-FU). Invitro

â&#x20AC;˘ Combination of curcumin and 5-FU may be useful to overcome 5-FU resistance in colorectal cancer (CRC) patients.

STUDY 11

Novel Evidence for Curcumin and Boswellic Acidâ&#x20AC;&#x201C;Induced Chemoprevention through Regulation of miR-34a and miR-27a in Colorectal Cancer.

Invitro

Combination of curcumin and AKBA enhances cytotoxicity and inhibits proliferation of colorectal cancer.

STUDY 12

Curcumin and major depression: a randomised, double-blind, placebocontrolled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change. EurNeuropsychopharmacol. 2015 Jan;25(1):38-50. doi: 10.1016/j. Murdoch university , Aus.

• In curcumin-treated individuals was associated with greater reductions in IDS-SR30 score. HCT

• The 30 item Inventory of Depressive Symptomatology (IDS) is designed to assess the severity of depressive symptoms. • IDS is available in the clinician (IDSC30) and self-rated versions (IDSSR30).

STUDY 12

HCT

â&#x20AC;˘ The IDS assess all the criterion symptom domains designated by the American Psychiatry Association Diagnostic and Statistical Manual of Mental Disorders.

STUDY 13

Curcumin mediates chemosensitization to 5-fluorouracil through miRNA-induced suppression of epithelialtomesenchymal transition in chemoresistant colorectal cancer Carcinogenesis, 2015, Vol. 36, No. 3, 355–367. Baylor University Medical Center.

Animal

• Curcumin-mediated sensitizationto 5FU (5-fluorouracil) in CRC (colorectal cancer) cells occurs through the suppression of EMT (epithelial–mesenchymal transition) and PRC (polycomb repressive complex), which are regulated by miRNAs (microRNA). • Polycomb group (PcG) proteins are master regulators of proliferation and development that play essential roles in human pathologies including cancers.

STUDY 14

BCM-95 and (2-hydroxypropyl)-βcyclodextrin reverse autophagy dysfunction and deplete stored lipids in Sap C-deficient fibroblasts.

• BCM-95 or HP-β-CD therapy could be used to treat clinically relevant secondary pathological aspects in Sap C deficiency. Invitro

•The ability of these two agents to enhance lysosomal function could be used to achieve new therapies for the treatment of other lysosomal storage diseases.

STUDY 14

BCM-95 and (2hydroxypropyl)-βcyclodextrin reverse autophagy dysfunction and deplete stored lipids in Sap C-deficient fibroblasts.

Invitro

• SAP-C seems to be essential for the degradation of glucosylceramide. Its genetic defect causes accumulation of the lipid also in the brain. In liver and spleen, a large accumulation of glucosylceramide, but not of other lipids, is found, while the level of βglucosidase is normal.

STUDY 14

BCM-95 and (2hydroxypropyl)-Î˛-cyclodextrin reverse autophagy dysfunction and deplete stored lipids in Sap C-deficient fibroblasts.

Invitro

STUDY 15

Evaluation of antidepressant like activity of Curcumin And its combination with fluoxetine and imipramine: An acute and chronic study. ActaPoloniaePharmaceutica ñ Drug Research, Vol. 68 No. 5 pp. 769ñ775, 2011. Department of Pharmacology, Government Medical College, Bhavnagar.

Animal Study

• Curcumin increased both the swimming and climbing behavior in FST (Forced Swim Test). • Its antidepressant like activity could be due to an increase in serotonin, norepinephrine and dopamine levels in the brain. • Curcumin can be a useful antidepressant especially in cases which respond to drugs having mixed effects on serotonin and catecholamines levels in the brain.

STUDY 16

Comparative Study of the Efficacy of Curcumin and Turmeric Oil as Chemopreventive Agents in Oral Submucous Fibrosis: A Clinical and Histopathological Evaluation. Journal of Indian Academy of Oral Medicine and Radiology, April-June 2010;22(2):88-92. Department of Oral Medicine and Radiology, Kerala.

HCT

The therapy with curcumin and turmeric oil is beneficial, affordable and noninvasive form of treatment in patients with OSMF(Oral submucous fibrosis).

STUDY 17

Oral Bioavailability of BCM-95® in Dogs” Poster presentation. 2009 ACVIM Forum/ Canadian VMA Convention: June 3-6, 2009;Montréal, Québec, Canada.

Animal

The BCM-95 group had approximately 7fold increase in absorption over plain curcumin over 8 hours and approximately 9-fold increase over plain curcumin when measured for 12 hours.

STUDY 18

A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95® CG (BiocurcumaxTM), A NovelBioenhanced Preparation of Curcumin.

HCT

• Curcumin is absorbed early and retained longer from the BCM-95®CG (BiocurcumaxTM) composition compared to normal curcumin as well as from curcumin-lecithin-piperine combination. • The results also indicate a probable role for the non-curcuminoid components of turmeric (especially Arturmerone) in the absorbability of curcumin in vivo.

STUDY 19

Curcumin effects on blood lipid profile in a 6-month human study. Pharmacological Research 56 (2007) 509â&#x20AC;&#x201C;514. The Chinese University of Hong Kong, Shatin,

HCT

Curcumin may increase rather than decrease cholesterol concentration.

STUDY 20

Bioavailability of Biocurcumaxtm (BCM â&#x20AC;&#x201C; 95).

HCT

Curcumin from Biocurcumax is retained in the blood for more than 8 hours in blood with higher level of curcumin in the blood.

STUDY 21

Effect of a topical curcumin preparation (BIOCURCUMAX) on burn wound healing in rats JPBMS, 2011, 08 (23) 1Dept. of Pharmacology, American university of Antigua.

Animal

Topical curcumin preparation is effective in healing burn wound and the effect was comparable to that of standard drug i.e. silver sulfadiazine.

STUDY 22

The Effect of Exercise and Nutritional Supplementation on Proinflammatory Cytokine Expression in Young Racehorses During Training Journal of Equine Veterinary Science xxx (2012) 1-11 University of Kentucky, Lexington, KY

Animal

â&#x20AC;˘ Although training itself was associated with an overall reduction in inflammatory markers, horses receiving the supplement exhibited further reductions in their indicators of inflammation. â&#x20AC;˘ As such, this study provides novel evidence of nutritional supplementation reducing post exercise inflammation.

STUDY 23

Evaluation of antiepileptic and memory retention activity of curcumin per se and in combination with antiepileptic drugs. Asian Journal of Pharmaceutical and Clinical Research. Department of Pharmacology, Government Medical College, Bhavnagar.

Animal

â&#x20AC;˘ This study shows that curcumin has antiepileptic activity in PTZ (Pentylenetetrazole ) induced seizure and has synergistic activity in combination with sodium valproate. â&#x20AC;˘So, curcumin can be used as an antiepileptic in absence seizure alone and as add on with sodium valproate.

STUDY 24

Anti-inflammatory activity of BCM-95 (bio-enhanced formulation of turmeric with increased bioavailabilty) compared to Curcumin in Wistar rats. Pharmacognosy Journal, Vol 8, Issue 4, Jul-Aug, 2016 380. Kasturba Medical College, Mangaluru, Manipal University, Manipal, INDIA.

Animal

Curcuminoids 95% (Curcumin) and BCM 95 had significant anti-inflammatory activity. The anti-inflammatory activity of BCM 95 is comparable to standard control group.

STUDY 25

Systematic and comprehensive investigation of the toxicity of curcuminoid essential oil complex: A bioavailable turmeric formulation MOLECULAR MEDICINE REPORTS 13: 592-604, 2016 DOI: 10.3892/mmr.2015.4579

Animal

CEC had no toxic effects in the animal models used, as per OECD guidelines. The results of the in vitro assessment also confirmed the non toxicity and safety of CEC. Taken together, CEC was observed to be non toxic and safe, and was supported by evidence from investigations of acute toxicity, repeated dose toxicity and mutagenicity. CEC: Curcumin Essential Oil Complex

STUDY 26

Curcumin and cognition: a randomised, placebo-controlled, double-blind study of communitydwelling older adults British Journal of Nutrition, page 1 of 8 doi:10.1017/ S0007114516001203

Animal

Prevent cognitive decline in a population of community-dwelling older adults. curcumin would have an effect on attenuating cognitive decline, rather than a direct effect on improving cognitive function.

STUDY 27

Effect of Curcumin Supplementation During Radiotherapy on Oxidative Status of Patients with Prostate Cancer: A Double Blinded, Randomized, Placebo-Controlled Study NUTRITION AND CANCER 2016, VOL. 0, NO. 0, 1â&#x20AC;&#x201C;9 Zanjan University of Medical Sciences, Zanjan, Iran;

HCT

Curcumin, an antioxidant agent, can increase the TAC(total antioxidant capacity) while it decreases the activity of antioxidant enzymes such as SOD (Superoxide dismutase)in patients with prostate cancer receiving radiotherapy. It was also showed that curcumin improves the antioxidant status of them without compromising the therapeutic efficacy of radiotherapy.

STUDY 28

â&#x20AC;˘ Oral leukoplakia is a potentially malignant lesion of the oral cavity, for which no effective treatment is available.

A Randomized Double-Blind Placebo-Controlled Phase IIB Trial of Curcumin in Oral Leukoplakia DOI: 10.1158/1940-6207.CAPR-15-039 0 3Roswell Park Cancer Institute, Buffalo, New York.

HCT

â&#x20AC;˘Treatment of oral leukoplakia with curcumin was well tolerated and demonstrated significant and durable clinical response.

STUDY 29

The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study. Eur J Phys Rehabil Med. 2016 Jun;52(3):321-30. Epub 2016 Mar 3. Bio-Medico university , Italy.

HCT

Treatment with Bio- Curcumin BCM-95ÂŽ with GH (Glucosamine Hydrochloride) and CS(Chondroitin Sulfate), accompanied by physical therapy, may improve pain symptoms during the activities of daily living and reduce algofunctionalLequesne Index values in mild to moderate knee OA (OsteoArthritis) patients. The index is used to assess the severity of osteoarthritis affecting knee joint through evaluation of daily activity and function.

STUDY 30

Short Report of a Preliminary Open Studyof Synofit-Containing Bio-Curcumin,Greenlipped Mussel and Blackcurrant Leaf Extract in Arthritis. Open Journal of Rheumatology and Autoimmune Diseases, 2015, 5, 113-117. MoliĂ¨re-Longchamp Hospital, Brussels.

HCT

Curcumin, greenlipped mussels and blackcurrant leaf have the reputation to bring some benefit in arthritis; for the first time, they are associated in one capsule and within 4 weeks of administration in low back pain and knee osteoarthritis, a slight but significant benefit is observed.

STUDY 31

Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebocontrolled study Journal of Affective Disorders 207 (2017) 188â&#x20AC;&#x201C;196 Murdoch University, Perth

HCT

Active drug treatments comprising differing doses of curcumin and combined curcumin/ saffron were effective in reducing depressive and anxiolytic symptoms in people with major depressive disorder.

STUDY 32

Effect of Infla-Kine supplementationon the gene expression of inflammatory markers in peripheral mononuclear cells and onC-reactive protein in blood J Transl Med (2017) 15:213 The Riordan Clinic, Wichita, KS, USA.

• Twice daily administration of Infla-Kine for 4 weeks reduces inflammatory markers and quality of life in healthy volunteers. HCT

• Infla-Kine is a natural supplement comprised of a proprietary blend of Lactobacillus fermentumextract, burdock seed (arctigenin), zinc, alpha lipoic acid, papaya enzyme and an enhanced absorptionbio-curcumin complex (BCM-95®).

STUDY 33

Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice Metab Brain Dis DOI 10.1007/ s11011-017-0133-y University of Lille, France.

Animal

â&#x20AC;˘ Curcumin treatment can partially counteract the metabolism disorders induced by risperidone at the levels of the metabolic pathways of fatty acids and glucose.

STUDY 34

Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice Metab Brain Dis DOI 10.1007/ s11011-017-0133-y University of Lille, France.

Animal

â&#x20AC;˘ Antipsychotics, such as risperidone, increase food intake and induce alteration in glucose and lipid metabolism concomitantly with overweight and body fat increase, these biological abnormalities belong to the metabolic syndrome definition (high visceral adiposity, ypertriglyceridemia, hyperglycemia, low HDL-cholesterol and high blood pressure).

STUDY 35

Curcumin and metformin-mediated chemoprevention of oralcancer is associated with inhibition of cancer stem cells.

Animal Molecular Carcinogenesis. 2017;56:2446–2460. Narayana Health, Bangalore,

• Curcumin in combination with metformin shows clinical response. Postchemopreventive treatment, the animals showed a reduced tumor size in all the treatment arms. • Clinical response of the animals was assessed by average tumor volume and Survival. The average tumor volume was reduced in the treatment arms.

STUDY 36

Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodiuminducedcolitis Scientific Reports | 7: 814 | DOI: 10.1038/s41598-017-00812-6 1 Baylor University Medical Center, Dallas,

Animal

ETO-curcumin (Essential Turmeric Oil â&#x20AC;&#x201C; Curcumin) improved disease activity index (DAI) dose-dependently,while the anti-inflammatory efficacy of standard curcumin remained constant, suggesting that ETO-curcumin may provide superior anti-inflammatory efficacy compared to standard curcumin.

STUDY 37

Efficacy and safety of curcumin and its combination with boswellic acid inosteoarthritis: a comparative, randomized, double-blind, placebocontrolled study. BMC Complementary and Alternative Medicine (2018) 18:7. Yerevan State Medical University of Armenia.

HCT

• Use of curcumin complex or its combination with boswellic acid reduces pain-related symptoms in patients with OA. • Curcumin in combination with boswellic acid is more effective. • Combining Curcuma longa and Boswellia serrata extracts in Curamin® increases the efficacy of OA(Osteoarthritis) treatment presumably due to synergistic effects of curcumin and boswellic acid.

STUDY 38

Suppression of Proliferation and Invasive Behavior of Human Metastatic Breast Cancer Cells by DietarySupplement BreastDefend. Integrative Cancer Therapies XX(X) 1â&#x20AC;&#x201C; 9.

Invitro

BD (BreastDefend)inhibits proliferation and invasive behavior of the highly metastatic human breast cancer cells in vitro. BD may have a therapeutic potential for prevention or treatment of highly metastatic breast cancers.

STUDY 39

Suppression of growth and invasive behavior of human prostate cancer cells by ProstaCaidTM: Mechanism of activity. INTERNATIONAL JOURNAL OF ONCOLOGY 38: 1675-1682, 2011. Indiana University School of Medicine, Indianapolis IN, USA.

Invitro

â&#x20AC;˘ ProstaCaid is a novel dietary supplement that contains multiple ingredients which show an anti-proliferation effect on androgen-dependent and -independent prostate cancer cells. â&#x20AC;˘ The results show that PC inhibits proliferation and invasive behavior of prostate cancer cells by the modulation of the expression of genes associated with prostate cancer.

STUDY 39

• The data suggest that PC has multiple targets for its therapeutic effect. Invitro

•The biological activity of PC is mediated by the additive or synergistic effects of its individual ingredients. • In summary, PC may have potential clinical application for an alternative prostate cancer therapy.

STUDY 40

ProstaCaid Induces G2/M Cell CycleArrest and Apoptosis in Human and Mouse Androgen– Dependent and –Independent Prostate Cancer Cells. Integrative Cancer Therapies 9(2) 186– 196. Columbia University Medical Center, New York.

Invitro

• Data from the studies indicate that ProstaCaid has anti-cancer activities in both AD and AI (androgen-dependent (AD) and independent (AI) )prostate cancer cells at very low concentrations. • Prostate cancers need relatively high levels of androgens to grow. Such prostate cancers are referred to as androgen dependent or androgen sensitive because treatments that decrease andro

STUDY 41

gen levels or blockandrogen activity can inhibit their growth. Invitro

• The dependency of prostate cancer growth and progression on testicular androgens, and hormonal ablation, either surgically or chemically, has been the main treatment for advanced prostate carcinoma.

STUDY 41

Invitro

• However, hormonal therapy only temporarily relieves the clinical symptoms, and no effective therapy is available for treating prostate cancer once the tumour becomes hormone independent.

STUDY 42

The Role of Turmerones on Curcumin Transportation and PGlycoprotein Activities in Intestinal Caco-2 Cells

Invitro J Med Food 15 (3) 2012, 242â&#x20AC;&#x201C;252 2State Key Laboratory of Phytochemistry and Plant Resources in West China,

In the presence of turmerones,amounts of curcumin transported from the apical side to the basolateral side (absorption) of Caco-2 cell monolayers were relatively higher than those without turmerones

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