NOBCChE 35th Annual Conference of NOBCChE | Philadelphia, PA | March 16-21, 2008

The 35th Annual Conference of The National Organization for the Professional Advancement of Black Chemists and Chemical Engineers

TABLE OF CONTENTS

Welcome Letters

Hotel Layout

ii

xi

Conference Sponsors

1

Conference at a Glance

3

NOBCChE Endowment Education Fund

Program Schedule

2008 Career Expo Exhibitors

Forum and Workshop Abstracts

Conference Speakers

Technical Abstracts

Poster Session Abstracts

National Conference Planning Committee

National Conference Planning Committee Subcommittees

9 12

57

61 75 101 173 229 230

Yolanda B. Cooper Vice President, Short Term & Multicultural Sales Philadelphia Convention & Visitors Bureau Thank you for selecting Philadelphia to serve as host to the 35th Annual Conference.

We invite you to re-live our nation’s heritage and patronize our African American establishments. In doing so, you will help support the Mission of our Multicultural Affairs Congress that works to ensure employment, management, educational and procurement opportunities for people of color in the Greater Philadelphia Community.

During your visit, be sure to visit our multicultural attractions, exhibits, museums, restaurants, shopping districts and diverse neighborhoods - all serving as the “square quilts” that weave our beautiful city together.

Discover recently uncovered historical ties between the struggle for freedom, visit many African-American sites such as Mother Bethel, the first AME church and tour major passageways of the Underground Railroad.

Whatever direction you take, dining at some of the world’s most famous restaurants and enjoying art exhibits at nationally known institutions, is only within footsteps. Go towards Olde City and taste soul food delight at its best. Entice your taste buds from Delilah’s Southern Cuisine, voted Best Macaroni and Cheese by Oprah Winfrey. End the evening by enjoying the jazz scene at WarmDaddy’s or hear current Philadelphia sounds at any of our renowned nightclubs.

Again, thank you for the opportunity to serve as host. We will continue to work diligently to ensure your experience is memorable and hope you will return again soon.

Sincerely, Yolanda B. Cooper

N BCChE

National Organization for the Professional Advancement of Black Chemists and Chemical Engineers

Dear NOBCChE Family and Friends,

On behalf of the Board of Directors of the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE), I welcome you to the 35th Annual Conference. It is my pleasure to invite you to actively participate in the technical programs, career fair, science bowl and fair,

exhibits, and teachers’ workshops. I encourage you to partake of the historical attractions in Philadelphia, PA. This yearʹs theme, ʺNOBCChE: 35 years of catalyzing scientific opportunities,ʺ signals NOBCChE’s commitment to enhancing the knowledge and skills of minority chemists and chemical engineers, which will enable them to build and protect the scientific infrastructure of our nation and our communities.

While this conference offers opportunities for African‐American scientists in academia, government, and industry to network, NOBCChE’s core mission is, and will remain, dedicated to preparing students to excel academically and to pursue careers in science and technology. In doing so, we support African‐ American scientists and engineers in developing and advancing their careers.

As you look through this conference program and develop a feel for the convention, I am confident you will increase your desire to understand the multifaceted world of chemistry and be inspired to pursue your future through NOBCChE.

Sincerely,

ADMINISTRATIVE STAFF President Victor McCrary, Ph.D. Johns Hopkins Physics Labs Baltimore, MD Vice-President John Harkless, Ph.D. Howard University Washington, DC Secretary Sharon J. Barnes, MBA/HRM The Dow Chemical Company Seadrift, TX Treasurer Lolita Grant, CPA. Atlanta, GA National Student Representative Sean Gant University of Michigan Ann Harbor, MI Midwest Regional Chair Judson Haynes, Ph.D. The Procter and Gamble Company Mason, OH Northeast Regional Chair Patrick Gordon, Ph.D. Emmanuel College Boston, MA Southeast Regional Chair James Grainger, Ph.D. Centers for Disease Control and Prevention Atlanta, GA Southwest Regional Chair Melvin Poulson Schering-Plough Animal Health Baton Rouge, LA West Regional Chair Isom Harrison Lawrence Livermore Natl. Lab Livermore, CA

EXECUTIVE COMMITTEE Bobby Wilson, Ph.D. Chairman Texas Southern University Houston, TX Perry Catching, Sr. MS, MBA Prime Organics Boston, MA Sandra Parker The Dow Chemical Company Midland, MI Denise Barnes, Ph.D. ITECS - Innovative Atlanta, GA Isiah Warner, Ph.D. Louisiana State University Baton Rouge, LA Ronald Lewis II, Ph.D. Pfizer, Inc. La Jolla, CA

Bobby L. Wilson, Ph.D.

Gloria Thomas MaGee, Ph.D. Xavier University New Orleans, LA Ella Davis Center Square, PA

P.O. Box 77040 Washington, DC 20013 202-667-1699

www.nobcche.org

N BCChE

National Organization for the Professional Advancement of Black Chemists and Chemical Engineers ADMINISTRATIVE STAFF

Victor M. McCrary, Ph.D. NOBCChE President 2008

President Victor McCrary, Ph.D. Johns Hopkins Physics Labs Baltimore, MD

I have been a member of NOBCChE all my academic and professional life and I’ve never been more proud to be part of the organization than I am today. Presiding over these committed scientists during our 35th Annual Conference is an honor. I hope this time with your mentors, students, colleagues and newfound friends provides you with a worthwhile experience.

This week, NOBCChE returns to its founding city of Philadelphia, where in 1972 four chemists and chemical engineers incubated the idea of a professional association for the advancement of African-Americans scientists and technologists.

The year’s conference theme, “NOBCChE: 35 Years of Catalyzing Scientific Opportunities,” serves to celebrate our achievements and to provide a physical environment for fostering connections between minority scientists in academia, government, and industry.

Under the direction of this year’s Nationa Chair, Sandra Parker (and an engineer!), the National Planning Committee has worked diligently for a year, planning your activities for this week. Take advantage of the general and plenary sessions, as well as the Health Symposium. Visit the Fairs and exhibitors, and attend the speaker breakfasts/luncheons and awards dinners. This year, we have attracted many high level and well-respected speakers, such as: James E. West, recipient of the 2006 National Medal of Technology; and James W. Mitchell, Ph.D., Packard Professor in Howard University's Department of Chemical Engineering, AT&T Bell Labs Fellow and the 1993 National Black Engineer of the Year.

Enjoy the conference and all that it offers to you professionally and personally.

Save some time to immerse yourself in the culture and history of our hosting city. I spent much time here in my youth and returned to earn my executive masters in technology management from the University of Pennsylvania. On so many levels, it’s nice to be home. Now, let’s use this annual meeting in the City of Brotherly Love to inspire and support each other to advance our roles in the chemical and chemical engineering professions. Remember – you are NOBCChE!!

Sincerely,

Vice-President John Harkless, Ph.D. Howard University Washington, DC Secretary Sharon J. Barnes, MBA/HRM The Dow Chemical Company Seadrift, TX Treasurer Lolita Grant, CPA. Atlanta, GA National Student Representative Sean S. Gant University of Michigan Ann Harbor, MI Midwest Regional Chair Judson Haynes, Ph.D. The Procter and Gamble Company Mason, OH Northeast Regional Chair Patrick Gordon, Ph.D. Emmanuel College Boston, MA Southeast Regional Chair James Grainger, Ph.D. Centers for Disease Control and Prevention Atlanta, GA Southwest Regional Chair Melvin Poulson Schering-Plough Animal Health Baton Rouge, LA West Regional Chair Isom Harrison Lawrence Livermore Natl. Lab Livermore, CA EXECUTIVE COMMITTEE Bobby Wilson, Ph.D. Chairman Texas Southern University Houston, TX Perry Catching, Sr. MS, MBA Prime Organics Boston, MA Sandra Parker The Dow Chemical Company Midland, MI Denise Barnes, Ph.D. ITECS - Innovative Atlanta, GA Isiah Warner, Ph.D. Louisiana State University Baton Rouge, LA Ronald Lewis II, Ph.D. Pfizer, Inc. La Jolla, CA Gloria Thomas MaGee, Ph.D. Xavier University New Orleans, LA Ella Davis Pfizer Lititz, PA

Victor M. McCrary, Ph.D.

P.O. Box 77040 Washington, DC 20013

www.nobcche.org

800-776-1419

N BCChE

National Organization for the Professional Advancement of Black Chemists and Chemical Engineers ADMINISTRATIVE STAFF

Greetings,

As the 2007‐2008 NOBCChE National Student Representative, I would like to welcome you to our 35th annual national meeting in the wonderful city of Philadelphia. Since our first national meeting held in New Orleans in 1974, we have been providing a rare opportunity for black professionals, students, and youth to foster their professional and social development.

NOBCChE has and will continue to be an organization committed to Securing a Community of Innovative, Energetic, and Notable Chemists and Engineers (SCIENCE). As such, I encourage you to attend many of the workshops that we have planned for you this week. I challenge you to attend one of the many research presentations throughout the week, and if you haven’t already, present your research at the next national meeting. Take the opportunity to talk to the numerous companies that will be attending our career expo and who are looking to recruit qualified people like you.

This year we are hosted by the city of Brotherly Love. When you have some down time, visit Penn’s Landing. Take a stroll and look at the rich history of Philadelphia. If you are hungry, make sure you get a real “Philly Cheese steak.”

Take advantage of the beautiful scenery and exciting nightlife that the city has to offer.

I hope that all of you enjoy your stay with us in Philadelphia and that this conference is worth your while. I look forward to meeting you!

Sincerely,

Sean S. Gant NOBCChE National Student Representative

P.O. Box 77040 Washington, DC 20013 800-776-1419

www.nobcche.org

President Victor McCrary, Ph.D. Johns Hopkins Physics Labs Baltimore, MD Vice-President John Harkless, Ph.D. Howard University Washington, DC Secretary Sharon J. Barnes, MBA/HRM The Dow Chemical Company Port Lavaca, TX Treasurer Lolita Grant, CPA Atlanta, GA National Student Representative Sean Gant University of Michigan Ann Arbor, MI Midwest Regional Chair Judson Haynes, Ph.D. The Procter and Gamble Company Mason, OH Northeast Regional Chair Patrick Gordon, Ph.D. Simmons College Boston, MA Southeast Regional Chair James Grainger, Ph.D. Centers for Disease Control and Prevention Atlanta, GA Southwest Regional Chair Melvin Poulson Schering-Plough Animal Health Baton Rouge, LA West Regional Chair Isom Harrison Lawrence Livermore Natl. Lab Livermore, CA EXECUTIVE COMMITTEE Bobby Wilson, Ph.D. Chairman Texas Southern University Houston, TX Perry Catchings, Sr. MS, MBA, Vice Chair Prime Organics, Inc. Woburn, MA Ella Davis, Member at Large 1374 Cherry Lane Center Square, PA 19422‐1804 Ronald Lewis II, Ph.D. Member at Large Pfizer, Inc. La Jolla, CA Gloria T. MaGee, Ph.D. Member at Large Xavier University New Orleans, LA Sandra Parker, Member at Large The Dow Chemical Company Midland, MI Isiah Warner, Ph.D., Member at Large Louisiana State University Baton Rouge, LA

N BCChE

National Organization for the Professional Advancement of Black Chemists and Chemical Engineers Zachary C. Cross President, Delaware Valley Chapter NOBCChE Hello Conference Attendees!

I am excited to welcome you to Philadelphia for the 35th annual meeting of NOBCChE! This meeting marks a major accomplishment for the organization as we continue to explore new avenues of addressing our mission statement of discovering, transmitting, and applying knowledge in the fields of science and engineering. As the host chapter, the Delaware Valley Chapter (DVC) would also like to welcome you to our great city. The DVC is celebrating over 25 years since we received our charter within NOBCChE. The theme for this year’s conference, 35 Years of Catalyzing Scientific Opportunities, stands as a proclamation of NOBCChE’s never ending efforts to remain a vital component of the scientific community.

As president of the Delaware Valley Chapter, I invite you to actively participate in this year’s meeting by attending technical sessions, workshops, and luncheons. To jumpstart the week’s activities the DVC will host a welcoming reception on Monday night. The advantage of Philadelphia is that you can experience America’s great history and be within arms reach of the country’s major pharmaceutical companies, biotechnology companies, and educational institutions. I encourage you to take full advantage of this opportunity to develop and nurture your professional networks, interact with companies, and empower yourselves by actively participating in the week’s conference activities.

I would like to highlight two activities that I encourage you to attend: the National Science competition (which consists of the Science Bowl and Science Fair) and the Career Fair. The Science Bowl and Science Fair feature junior high and high school students who are the future of the scientific community. The Career Fair will feature major companies in the area so use this time to advance or change your career path.

I look forward to meeting new members, reconnecting with old friends, and I extend a warm welcome to my city.

ADMINISTRATIVE STAFF President Victor McCrary, Ph.D. Johns Hopkins Physics Labs Baltimore, MD Vice-President John Harkless, Ph.D. Howard University Washington, DC Secretary Sharon J. Barnes, MBA/HRM The Dow Chemical Company Seadrift, TX Treasurer Lolita Grant, CPA. Atlanta, GA National Student Representative Sean Gant University of Michigan Ann Harbor, MI Midwest Regional Chair Judson Haynes, Ph.D. The Procter and Gamble Company Mason, OH Northeast Regional Chair Patrick Gordon, Ph.D. Emmanuel College Boston, MA Southeast Regional Chair James Grainger, Ph.D. Centers for Disease Control and Prevention Atlanta, GA Southwest Regional Chair Melvin Poulson Schering-Plough Animal Health Baton Rouge, LA West Regional Chair Isom Harrison Lawrence Livermore Natl. Lab Livermore, CA EXECUTIVE COMMITTEE Bobby Wilson, Ph.D. Chairman Texas Southern University Houston, TX Perry Catching, Sr. MS, MBA Prime Organics Boston, MA Sandra Parker The Dow Chemical Company Midland, MI Denise Barnes, Ph.D. ITECS - Innovative Atlanta, GA Isiah Warner, Ph.D. Louisiana State University Baton Rouge, LA Ronald Lewis II, Ph.D. Pfizer, Inc. La Jolla, CA

Sincerely,

Gloria Thomas MaGee, Ph.D. Xavier University New Orleans, LA Ella Davis Pfizer Lititz, PA

P.O. Box 77040 Washington, DC 20013

www.nobcche.org

800-776-1419

N BCChE

National Organization for the Professional Advancement of Black Chemists and Chemical Engineers ADMINISTRATIVE STAFF

Sandra K. Parker NOBCChE National Conference Chair

President Victor McCrary, Ph.D. Johns Hopkins Physics Labs Baltimore, MD Vice-President John Harkless, Ph.D. Howard University Washington, DC

It is with great anticipation that I welcome each of you to our 2008 national conference. I can say with confidence that we have something for everyone this year. Whether you’re a high school student or teacher, new graduate or working professional, this annual meeting will meet your expectations. It is here where NOBCChE began, in the city of Philadelphia, that we take great pride in celebrating “35 years of Catalyzing Scientific Opportunities.”

Last year we took the opportunity to gather feedback from our conference participants to see what changes you’d like to see us implement. As a result, there are several new programs we are introducing this year. There are a series of Professional Development Workshops, more Technical Sessions and this year we are happy to welcome recording artist, Bobbi Humphrey – First Lady of Flute to our annual Awards Banquet. We’ve worked hard to ensure that the entire Philadelphia Community has an opportunity to come out and participate in our conference with our annual Health Symposium where we focus on the AIDS epidemic that is so rapidly an issue in the African-American community as well as our Career Expo, where several companies, academic institutions and organizations will be available to discuss career choices and job opportunities. It’s a chance for all attendees to meet future employers and mentors -- undergraduate/graduate students preparing to enter the workforce or seek higher education, professionals who are looking for career changes, and high school students finalizing college choices and validating their educational goals with science or engineering.

We exist primarily to support the process of preparing young people to excel academically and to pursue careers in science and technology. So, we thank all the registrants, sponsors and supporters of NOBCChE for making this conference a reality.

Philadelphia, a city so rich in history and often referred to as the City of Brotherly Love provides a wonderful backdrop for us to come together to commit to improving the skills we possess and forwarding the chemical profession. Enjoy the conference!

Secretary Sharon J. Barnes, MBA/HRM The Dow Chemical Company Seadrift, TX Treasurer Lolita Grant, CPA. Atlanta, GA National Student Representative Sean Gant University of Michigan Ann Harbor, MI Midwest Regional Chair Judson Haynes, Ph.D. The Procter and Gamble Company Mason, OH Northeast Regional Chair Patrick Gordon, Ph.D. Emmanuel College Boston, MA Southeast Regional Chair James Grainger, Ph.D. Centers for Disease Control and Prevention Atlanta, GA Southwest Regional Chair Melvin Poulson Schering-Plough Animal Health Baton Rouge, LA West Regional Chair Isom Harrison Lawrence Livermore Natl. Lab Livermore, CA EXECUTIVE COMMITTEE Bobby Wilson, Ph.D. Chairman Texas Southern University Houston, TX Perry Catching, Sr. MS, MBA Prime Organics Boston, MA Sandra Parker The Dow Chemical Company Midland, MI Denise Barnes, Ph.D. ITECS - Innovative Atlanta, GA Isiah Warner, Ph.D. Louisiana State University Baton Rouge, LA

Sincerely,

Ronald Lewis II, Ph.D. Pfizer, Inc. La Jolla, CA

Sandra K. Parker

Gloria Thomas MaGee, Ph.D. Xavier University New Orleans, LA Ella Davis Pfizer Lititz, PA

Sandra K. Parker 2008 Conference Chair P.O. Box 77040 Washington, DC 20013

www.nobcche.org

800-776-1419

WE'RE IN THE BUSINESS OF MAKING YOURS MORE ENJOYABLE.

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The Philadelphia Marriott Downtown welcomes NOBCChE's 35th Annual Conference. Thank you for your business, we look forward to your arrival!

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Philadelphia Marriott Downtown 1201 Market Street Philadelphia, PA 19107 Phone: (215)625-2900 Fax: (215)625-6000 philadelphiamarriott.com

Marriott Downtown Philadelphia Floor Plans

4th Floor Franklin Hall Meeting Space

5th Floor Grand Ballroom

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CONFERENCE SPONSORS

Our Sponsors THANK You for Contributing to the Overall Success of our conference – we salute you! ******** 3M American Association for the Advancement of Science (AAAS) Agilent Technologies American Chemical Society Bayer Material Science Brazoria County Area Chapter – NOBCChE Colgate-Palmolive Committee for Action Program Services (CAPS) Committee on the Advancement of Women Chemists (COACh) Delaware Valley Chapter – NOBCChE The Dow Chemical Company Dupont Eastman Kodak Company 1

CONFERENCE SPONSORS Eli Lilly & Company Florida A&M University – Science Institute GlaxoSmithKline Howard University The Johns Hopkins University – Applied Physics Laboratory The Lubrizol Corporation MIT Chemistry Northeast Section – American Chemical Society National Institute of Standards & Technologies (NIST) National Science Foundation Rohm and Haas Pfizer Procter & Gamble Roche University of Maryland – College Park Xavier University of Louisiana

2

CONFERENCE AT A GLANCE Date

Description

Room

Sunday

March 16

7:00 AM – 8:00 AM

COACh Registration

4th Floor Foyer

8:00 AM – 5:00 PM

COACh Workshop I – The Chemistry of Leadership

Roon 410

8:00 AM – 5:00 PM

COACh Workshop II – Professional Skills Training for Minority Graduate Students and Postdocs

Roon 411

8:00 AM – 5:00 PM

Agilent HPLC (2D) Data Analysis and Reporting 403 ‐ Day 1 (pre‐paid)

8:00 AM – 5:00 PM

Seven Habits of Highly Effective People (pre‐paid)

Franklin 11

4:00 PM ‐ 6:00 PM 6:00 PM – 8:00 PM

Franklin Foyer Salon I

Conference Registration Welcome Reception (Sponsored by COACh and NOBCChE)

Monday

March 17

7:00 AM – 8:00 AM 7:30 AM – 9:30 AM

NPC Committee Meeting Expanded Coffee Service

402 Franklin Foyer

Sponsored by Brazoria County Area Chapter

7:30 AM – 4:00 PM

Conference Registration (closed 8:00 – 9:00 AM)

Franklin Foyer

8:00 AM – 9:00 AM

Opening Session

Salon C‐D

9:00 AM ‐ 5:00 PM

Agilent HPLC (2D) Data Analysis and Reporting ‐ Day 2 (pre‐paid) 403

9:00 AM ‐ 10:00 AM

Plenary I ‐ Bioapplications in Chemistry

Franklin 1

10:00 AM ‐ 12:00 PM 10:00 AM ‐ 12:00 PM

Technical Session 1: Inorganic Chemistry Technical Session 2: Biochemistry and Biotechnology Applications

Room 410 Franklin 1

3

CONFERENCE AT A GLANCE

Monday, March 17 (Cont.)

11:00 ‐ 12:00 PM

Henry Hill Lecture Speaker – James E West, The Johns Hopkins University Sponsored by Northeast Section of ACS and MIT Chemistry Department

12:00 PM ‐ 1:30 PM

Opening Luncheon Speaker – Dr. James W. Mitchell, Howard University (ticketed)

1:45 PM ‐ 3:45 PM

1:45 PM ‐ 3:30 PM

3:45 PM ‐ 5:45 PM

3:30 PM ‐ 5:30 PM

Technical Session 3: Henry McBay Outstanding Teacher Symposium‐Chemical Education Technical Session 4: Bioapplications in Physical Chemistry Technical Session 5: Nanotechnology Applications 1 Technical Session 6: Bioapplications in Materials Chemistry

6:00 PM ‐ 8:00 PM

Host Chapter Reception ‐ Delaware Valley Chapter’s 25 Anniversary Celebration

10:00 PM – 12:00 AM

Tuesday

Franklin 2

Salon H

Room 410 Room 411 Room 410 Room 411

Salon H

Hospitality Room

Rooms 411 & 412

March 18

The Johns Hopkins University Applied Physics Laboratory Technical Day

7:00 AM – 8:00 AM NPC Committee Meeting 413 7:00 AM ‐ 5:00 PM Teachers Workshop ‐ Day 1 Salon IJ Expanded Coffee Service 7:30 AM – 9:00 AM Franklin Foyer Sponsored by Howard University Chemistry Department

8:00 AM ‐ 4:00 PM

Conference Registration

4

Franklin Foyer

CONFERENCE AT A GLANCE

Tuesday, March 18 (Cont.)

8:30 AM ‐ 9:30 AM 9:00 AM ‐ 4:00 PM 9:45 AM ‐ 11:45 AM

Plenary II ‐ Nanotechnology in Chemistry Symposium

Franklin 1 Franklin B Room 411

9:45 AM ‐ 11:45 AM 9:45 AM ‐ 11:45 AM

Career Fair Setup for Exhibitors Technical Session 7: Biofuels Technical Session 8: Nanotechnology Applications 2 Technical Session 9: Physical Chemistry

Franklin 1 Room 412

12:00 PM ‐ 1:30 PM

Percy Julian Symposium Luncheon Speaker – Dr. Sharon Haynie, DuPont Company (ticketed)

Salon H

6:00 PM ‐ 8:00 PM 10:00 PM – 12:00 AM

Rohm & Haas /NOBCChE Undergraduate Competition

Graduate Students Shoppers Delight: GEM Information Session and Graduate Survival Tips Technical Session 10: Graduate Students Sci‐Mix Symposium Next Generation Process Automation at The Dow Chemical Company: The Journey to Commercial Solutions Plenary III ‐ Health Symposium sponsored by Eli Lilly Company Exhibitorʹs Welcome Reception sponsored

by University of Maryland College Park Hospitality Room

Salon H Salon H

Wednesday

March 19

7:00 AM ‐ 7:30 AM

NPC Committee Meeting

Room 402

7:30 AM ‐ 9:00 AM

Plenary IV ‐ Jumpstarting Your Career & Breakfast (ticketed)sponsored by Rohm and Haas Corporation

Salon H

7:30 AM ‐ 5:00 PM

Teachers Workshop ‐ Day 2

Salon IJ

8:00 AM ‐ 4:00 PM

Conference Registration

Franklin Foyer

1:45 PM ‐ 3:45 PM

1:45 PM ‐ 3:00 PM

1:45 PM ‐ 3:30 PM

3:00 PM ‐ 5:00 PM 4:00 PM ‐ 6:00 PM

5

Franklin 1

Room 411

Room 412

Room 413 Salon G

CONFERENCE AT A GLANCE 8:00 AM ‐ 5:00 PM

You Donʹt Know What You Donʹt Know: Emotional Intelligence

Room 411

Wednesday, March 19 (Cont.)

9:00 AM ‐ 6:00 PM

9:00 AM ‐ 11:00 AM 10:00 AM ‐ 11:00 AM

2:00 PM ‐ 5:00 PM 2:00 PM 3:30 PM 4:00 PM ‐ 5:00 PM 5:30 PM ‐ 9:30 PM 5:00 PM ‐ 7:00 PM

CAREER FAIR EXPO

Managing an Effective Job Search sponsored by ACS Our Chemistory: Celebrating Our History in the Chemical Sciences

LUNCH ON YOUR OWN

Professional Development Workshops ‐ ACS Leadership Development NSF and DOD Fellowship Informational Session ACS Distinguished Scientist Science Competition Registration & Opening Meeting

NOBCChE Scientific Exchange Poster Session

Franklin B

Room 412 Franklin 1

Room 414 Room 415 Salon KL Salon G Franklin A

7:00 PM – until 10:00 PM – 12:00 AM

A NIGHT ON THE TOWN Hospitality Room

Salon H

Thursday

March 20

Plenary V ‐ State of the Organization ‐ A Roadmap Review Science Fair Setup Conference Registration Technial Session 11: Lloyd Ferguson Young Scientist Award Symposium‐ Bioapplications in Organic Chemistry

7:30 AM ‐ 9:00 AM 8:00 AM ‐ 9:00 AM 8:00 AM ‐ 4:00 PM 9:00 AM – 11:15 AM

6

Salon G Franklin 1 & 2 Franklin Foyer Room 410

CONFERENCE AT A GLANCE

Thursday, March 20 (Cont.)

9:00 AM – 11:15 AM 9:00 AM – 11:15 AM 9:00 AM – 11:00 AM 11:00 AM – 12:00 PM

Technical Session 12: NOBCChE Professional Chemical Engr Award Symposium Technical Session 14: Analytical Chemistry

Room 407 Room 406 Franklin 1 & 2 Franklin 1 & 2

1:30 PM ‐ 2:30 PM

Science Fair Public Viewing Science Fair Judging Technical Session 13: Bioapplications in Chemical Engineering Technical Session 15: Organic Chemistry Milligan Competition

LUNCH ON YOUR OWN

Science Bowl Competitions: Senior Division Science Bowl Competitions: Junior Division Midwest Regional Meeting

Northeast Regional Meeting

Room 406

Southeast Regional Meeting

Room 407

Southwest Regional Meeting

Room 410

West Regional Meeting

Room 413

11:30 AM ‐ 1:00 PM 11:30 AM ‐ 1:00 PM 12:00 PM ‐ 3:30 PM

1:00 PM ‐ 5:00 PM 1:00 PM ‐ 5:00 PM

2:30 PM ‐ 3:30 PM 2:30 PM ‐ 3:30 PM 3:00 PM ‐ 5:00 PM 3:00 PM ‐ 5:00 PM 6:00 PM ‐ 8:00 PM 9:00 PM ‐ 12:00 PM

LOCAL CHAPTER MANAGEMENT SESSION Chapter Presidents/Treasurer ‐ Mandatory HBCU Presentation & Panel Discussion Technical Session 16: Bioapplications in Analytical Chemistry Technical Session 17: Materials/Polymers Chemistry Science Competition Dinner Science Competition Social Activity

Room 410 Room 406 Room 411

Franklin 8, 9, 10 Franklin 11, 12, 13 Room 403

Room 415 Franklin 7 Room 412 Room 414 Salon H Salon H

7:00 PM ‐ 10:00 PM

Plenary VII ‐ Awards Ceremony & Gala Dinner Special Guest: Bobbi Humphrey – First Lady of Flute

Salons G, K, L

10:00 PM – 12:00 AM

Hospitality Room

Salon H 7

CONFERENCE AT A GLANCE

Friday

March 21

Expanded Coffee Service

7:30 AM – 9:00 AM

Sponsored by Atlanta Metro Chapter and ACS Northeast Section

Franklin Foyer

8:00 AM – 11:30 AM 8:00 AM – 11:30 AM

Science Bowl Finals: Senior Division Science Bowl Finals: Junior Division

Franklin 12 Franklin 13

11:30 AM ‐ 2:00 PM

Science Competition Awards Luncheon (ticketed) sponsored by Agilent Technologies

Salon H

2:30 PM

Science Competition Educational Trip ‐ Franklin Institute

Offsite

8

NOBCChE ENDOWMENT EDUCATION FUND

We wish to thank members and friends of the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers for their support and confidence in the future of NOBCChE by making a $500.00 or more tax deductible contribution to the NOBCChE Endowment Education Fund.

Mildred Allison Denise Barnes Iona Black* Henry T. Brown Winifred Burks‐Houck Virlyn Burse* Joseph N. Cannon Callista Chukwunenye Robert L. Countryman Andrew Crowe* Darrell Davis Anthony L. Dent* Lawrence E. Doolin* Linneaus Dorman* Fannie Posey Eddy James Evans, Sr. Lloyd Ferguson Lonnie Fogel Lloyd Freeman Eddie Gay Joseph Gordon* William Guillory* Jonathan K. Hale James Harris Bruce Harris* Ivory Herbert Kenneth W Hicks Neville Holder Isaac B. Horton, III Donald A. Hudson Charles R. Hurt

William M. Jackson* Madeleine Jacobs* Christopher Kinard Anita Osborne‐Lee George Lester, Jr. William A Lester, Jr. Mallinkrodt Chemical Inc. Willie May Jefferson McCowan* Victor McCrary Sidney McNairy Lynn Melton Philip Merchant Reginald E. Mitchell William V. Ormond* James A. Porter Cordelia M. Price* Marquita Qualls* Janet B. Reid Leonard E. Small* Florence P. Smith Michael Stallings* Clarence Tucker* Benjamin Wallace* Charles Washington Joseph Watson Billy Williams Keith B. Williams Reginald Willingham Bobby Wilson Andrea Young*

* Contributed more than $500.00

9

NOBCChE ENDOWMENT EDUCATION FUND

We wish to thank members and friends of the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers for their support and confidence in the future of NOBCChE, and for their tax deductible contribution to the NOBCChE Endowment Education Fund.

Adegboye Adeyeno Keith Alexander Verlinda Allen Eugene Alsandor Roseanne Anderson Victor Atiemo‐Obeng Benny Askew, Jr. Joseph Barnes Sharon Barnes Tegwyn L. Berry Alfred Bishop Jeanette E. Brown Nora Butler‐Briant James Burke Jacqueline Calhoun Lashanda Carter Perry Catchings, Jr. Aldene Chambles John J. Chapman Esteban Chornet Reginald A. Christy Regina V. Clark James Clifton Edward Coleman George Collins James E. Cotton Garry S. Crosson Reuben Daniel Kowetha Davidson Ella Davis Thomas Davis Thomas Dill Gerald Ellis Lisa Batiste‐Evans Pat Fagbayi

Edward Flabe Edward E. Flagg Joe Franklin Russell Franklin Issac Gamwo John W. Garner Cornelia Gilyard Robert Gooden Warren E. Gooden Valerie Goss Etta Gravely Bernice Green Garry Grossman Keith V. Guinn Everett B. Guthrie Gene S. Hall James Hamilton Kinesha Harris April Harrison Isom Harrison Rogers E. Harry‐Oruru Lincoln Hawkins Ronald Haynes Ronald L. Henry Leonard Holley Sydana R. Hollins Smallwood Holoman, Jr. Brenda S. Holmes Nikisha Hunter Bernard Jackson Donald Jackson Evelyn P. Jackson Kim Jackson Kyle Jackson Raymond James

Ganiyua Jaiyeola Allene Johnson Elijah Johnson Harry Johnson Paula Johnson Saphronia Johnson Emmett Jones Evy Jones Jennifer A. Jones Jesse Jones Timothy Jones Thomas C. Jones Verlinda Jordan Jimmie Julian Ella L. Kelly Otis Kems Kirby Kirksey Rachel Law Mia Laws Lester A. Lee Cynthia R. Leslie Steve Lucas Alex Maasa Dale Mack George S. Mack Robert McAllister Aliecia McClain Gerald McCloud Jefferson McCowan Walter McFall Saundra Y. McGuire Dawn McLaurin Linda Mead‐Tollin Janice Meeks Charles W. Merideth

10

NOBCChE ENDOWMENT EDUCATION FUND

M. P. Moon Damon Mitchell Robert Murff Harvey Myers Tina Newsome James Nichols Kenneth Norton Bunmi Ogunkeye Steven B Ogunwumi Mobolaji O. Olwinde Kofi Oppong Soni Oyekan Beverly Paul James Pearce James Pearson Tony L. Perry Howard Peters Mwita V Phelps Walter G. Phillips Louis Pierce Sonya Caston Pierre Wendell Plain Charles A. Plinton Melvin Poulson

Jamacia Prince Daniel Reuben Mary Robinson Press Robinson Anne Roby Tommie Royster Albert E Russell Franklin Russell Clark Scales Billy Scott Melva Scott Robert Shepard James P Shoffner Keroline M. Simmonds Tiffany Simpson Milton Sloan Karen Speights ‐ Diggs Oreoluwa Sofekun Lucius Stephenson Wilford Stewart Grant St. Julian Richard Sullivan Albert Thompson Dameyun Thompson

11

Ezra Totton Jorge Valdes Grant Venerable Cheryl A. Vocking Emmanuel Waddell Samuel von Winbush Gerald Walker Leon C. Warner Michael Washington Odiest Washington Ben Watson Joseph W. Watson Helen P. White Ronald H. White Thomas Whitt Leonard Wilmen Harold Lloyd Williams Laura C. Williams Joe Williams Raymond Williams Jeremy Willis Sean Wright Sandra Wyatt

PROGRAM SCHEDULE DAY OF WEEK

EVENT

Sunday

ROOM

March 16

7:00 AM – 8:00 AM

COACh Registration

4th Floor Foyer

Sunday AM/PM

COACh Workshop I – The Chemistry of Leadership 8:00 AM – 5:00 PM

Room 410

Facilitator: Sandra Shullman, Managing Partner, Columbus Office, Executive Development Group, COACh Workshop II – Sunday AM/PM 8:00 AM – 5:00 PM Room 411

Professional Skills Training for Minority Graduate Students and Postdocs Committee on the Advancement of Women Chemists Facilitators: Jane Tucker, Director, Human Resources, Teaching and Organizational Development, Duke University ; Ernestine Taylor, Senior Associate, Center for Creative Leadership; Ernestine Taylor, Founder and President, ETConsulting

8:00 AM – 5:00 PM

Agilent HPLC (2D) Data Analysis and Reporting Room`403 ‐ Day 1 (pre‐paid)

8:00 AM – 5:00 PM

Seven Habits of Highly Effective People (pre‐ paid)

Room 411

4:00 PM ‐ 6:00 PM

Conference Registration

Franklin Foyer

6:00 PM – 8:00 PM

Welcome Reception (Sponsored by COACh and NOBCChE)

Salon I

Monday

March 17

7:00 AM – 8:00 AM 7:30 AM – 9:00 AM

NPC Committee Meeting Expanded Coffee Service

402 Franklin Foyer

Sponsored by Brazoria County Area Chapter

7:30 AM – 4:00 PM

Conference Registration (closed 8:00 – 9:00 AM) 12

Franklin Foyer

PROGRAM SCHEDULE

Monday, AM

Opening Session 8:00– 9:00 AM

Welcome

Dr. Victor R. McCrary, NOBCChE National President,

Salon C‐D…..

Greetings

From The City Philadelphia City Officials

Executive Board Dr. Bobby Wilson, Chairpman of National Executive Board

Whatʹs In Store Dr. Victor R. McCrary, NOBCChE President

Conference Overview Ms. Sandra Parker, National Conference Chair

Closing Remarks Dr. Victor R. McCrary

9:00 AM ‐ 5:00 PM

Agilent HPLC (2D) Data Analysis and Reporting ‐ Room 403 Day 2 (pre‐paid)

Monday, AM

Plenary I ‐ Bioapplications in Chemistry 9:00 AM ‐ 10:00 AM

Franklin 1

Dr. Stephen L. Mayo

Presenter

Vice Provost and Bren Professor of Biology and Chemistry, California Institute of Technology, Pasadena, CA “Recent Progress in Computational Protein Design: Towards Designing Enzymes and Combinatorial Protein Libraries”

13

PROGRAM SCHEDULE

Monday, AM

10:00 AM – 10:20 AM

Technical Session 1 10:00 AM – 12:00 N Inorganic Chemistry (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation

Room 410

“Investigative Studies Of The Reduction Of A Series Of Mo(VI)‐Ligand Complex Using UV‐Vis, FT‐IR, And FT‐NMR Spectroscopy” Josiah Wrensfort1, Alicia Kelly1, Juan Miguel Maldonado1, Olivia Penrose2, Clifford F. Denize2, Doreen O. Jackson2, and Kenneth W. Hicks*2.

10:20 AM – 10:40 AM

10:40 AM – 11:00 AM

11:00 AM – 11:05 AM

11:05 AM – 11:25 AM

Department of Biology1 and Department of Chemistry2, Norfolk State University, 700 Park Avenue, Norfolk, VA

“Synthesis And Reactivity Of High Oxidation Organometallic Palladium And Platinum Complexes” Salena R. Whitfield* and Melanie S. Sanford University of Michigan, Department of Chemistry, Ann Arbor, MI

“Palladium‐Mediated Halogenation Of Carbon‐Hydrogen Bonds” Nicholas D. Ball, Melanie S. Sanford* Department of Chemistry, University of Michigan, Ann Arbor, MI

Break

“Spectroscopic And Computational Studies Of Nickel Superoxide Dismutase: Roles Of The Cysteine‐2 And ‐6 Active Site Ligands ” Olivia E. Johnson1, Thomas Brunold1* 1Department of Chemistry, University of Wisconsin‐Madison,

11:25 AM – 11:45 AM

Madison, WI

“1.54 μM Emission Characteristics In Highly Crystalline Er:Zno Films Synthesized By Pulsed‐Laser Deposition”

L. Douglas, H. Mustafa, R. Mundle, C.E. Bonner, and A.K. Pradhan Center for Materials Research, Norfolk State University, 700 Park Avenue, Norfolk, VA 14

PROGRAM SCHEDULE 11:45 AM – 11:50 AM

Poster Talk “Titanium Catalyzed 3‐Component Coupling & Intramolecular Asymmetric Hydroamination Of Aminoalkenes” Kevin R. Gipson1, Aaron L. Odom*2, Supriyo Majumder3 Michigan State University , Department of Chemistry, East Lansing, MI

Technical Session 2 10:00 AM – 12:00 N Biochemistry and Biotechnology Applications (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation

Monday, AM

Franklin 1

10:00 AM – 10:30 AM

10:30 AM – 10:45 AM

Highlighted Speaker “Taking A Hit For The Team: Self‐Sacrifice As An Enzymatic Strategy In The Biosynthesis Of Lipoic Acid” Squire J. Booker Associate Professor of Biochemistry and Molecular Biology, Penn State University

“Time Resolved UV Resonance Raman Studies of Nucleic Acid Base Stacking” Alison Williams*1 and Ishita Mukerji2 1Princeton University, Department of Molecular Biology, Princeton, NJ 2Wesleyan University, Department of Molecular Biology and

10:45 AM – 11:00 AM

11:00 AM – 11:15 AM

Biochemistry, Middletown, CT

“Single Molecule Studies Of Lac Repressor‐Induced DNA Loops” Kathy Goodson, Sara Lioi, Aaron Haeusler, Jason Kahn, Douglas English* University of Maryland, Department of Chemistry & Biochemistry, College Park, MD

“Solution Structure And Backbone Dynamics Studies Of An Oncogenic Mutant Of The Ras Protein Cdc42Hs Outlines The Molecular Basis Of Its Aberrant Cell Signaling” Paul D. Adams*1 and Robert E. Oswald2 1Department of Chemistry and Biochemistry, University of Arkansas, 15

PROGRAM SCHEDULE Fayetteville, AR; 2Department of Molecular Medicine, Cornell University College of Veterinary Medicine, Ithaca, NY

“Role Of The Central Hydrogen‐Bonding Network Interdomain Residues In The Bifunctionality Of Catalase‐Peroxidases” Carma O. Cook and Douglas C. Goodwin Auburn University Department of Chemistry and Biochemistry, Auburn University, AL

“Strucuture‐Based Discovery Of Novel LPA3 Antagonists”

11:15 AM – 11:30 AM

11:30 AM – 11:45 AM

James I. Fells, Sr.*1, Ryoko Tsukahara2, Jianxiong Liu2, Abby L. Parrill1, and Gabor Tigyi2 1Department of Chemistry and Computational Research on Materials Institute, The University of Memphis, Memphis, TN 2Department of Physiology, University of Tennessee Health Science Center, Memphis, TN

Henry Hill Lecture

Monday, AM

11:00 ‐ 12:00 PM

Franklin 2. .

Speaker – James E West, The Johns Hopkins University Sponsored by Northeast Section of ACS and MIT Chemistry Department

Opening Luncheon Monday, AM

Salon H

12:00 PM ‐ 1:30 PM (ticketed)

Dr. James W. Mitchell, Luncheon Speaker

David and Lucille Packard Professor, Chemical Engineering Department, Howard University “Nanosciences and Nanotechnology: Continuing Challenges and Opportunities for Chemists and Chemical Engineers”

16

PROGRAM SCHEDULE

Monday, PM

1:45 PM – 2:15 PM

2:15 PM – 2:35 PM

Technical Session 3 1:45 PM – 3:45 PM Henry McBay Outstanding Teacher Symposium – Chemical Education (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation

Room 410

Dr. Henry McBay Outstanding Teacher Awardee “Morgan´s CURE: Continuous Undergraduate Research Experience” Alvin P. Kennedy Department of Chemistry, Morgan State University

“Action And Strategies For Improving Performance In General Chemistry At Florida A&M University” 1Serena. Roberts, 2Jamar. Robinson, 2Antoinette. Addison, 3 Milagros Ignatz, 4Ruppert. Giroux, 2Marc. Weininger, 2Reginald. Little, 2Bereket.

Mochona, 1, 5Marcia. Owens, 2Modeline. Blanchard 2Jesse Edwards 1Teacher Learning Institute/Teachers for a New Era , 2Chemistry Department, , 3College of Education, 4Industrial and Manufacturing Engineering, FAMU/FSU College of Engineering, and 5Environmental

2:35 PM – 2:55 PM

2:55 PM – 3:15 PM

3:15 PM – 3:35 PM

Sciences Institute, Florida A&M University, Tallahassee, Florida

“Incorporation Of Critical Thinking Skills Into Research” Angela J. Winstead*, Alvin P. Kennedy Morgan State University, Department of Chemistry, Baltimore, MD

“Inquiry‐Based Laboratories In Undergraduate Research Development Program” Yongchao Zhang*, Angela J. Winstead Department of Chemistry, Morgan State University, Baltimore, MD

“Enhancing The Science Curriculum Of K‐12 Students” Nichole L. Powell*, Albert E. Russell, Barbara G. Rackley, Gregory Pritchett, and Pamela M. Leggett‐Robinson Tuskegee University, Department of Chemistry, Tuskegee, AL

17

PROGRAM SCHEDULE Technical Session 4 1:45 PM – 3:30 PM Bioapplications in Physical Chemistry (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation

Monday, PM

Room 411

1:45 PM – 2:15 PM

2:15 PM – 2:30 PM

Highlighted Speaker “Gold Alkanethiol Self‐Assembled Monolayers As Building Blocks For Site Directed Drug Delivery For Structural Biomedical Implants” Carl E. Bonner, Jr., Chanel Smith, Rahul Buhre, Anil Mahapatro, Center for Materials Research, Norfolk State University, 700 Park Avenue, Norfolk, VA

“Understanding Protein Diffusion Versus Biopolymer Volume Fraction In Live Escherichia coli” Colin J. Ingram1, Ben P. Bratton1, Michael C. Konopka1, Roman V. Belousov1, Kem A. Winter1, Irina A. Shkel1, M Thomas Record, Jr.1,2, and James C. Weisshaar*1 1University of Wisconsin, Department of Chemistry, Madison, WI 2University of Wisconsin, Department of Biochemistry, Madison, WI

2:30 PM – 2:45 PM

“Quantum Mechanical Prediction Of Fluorine NMR Chemical Shifts In Biologically Relevant Compounds” Duane Williams*1, Martin B. Peters1 and Kenneth M. Merz, Jr.1 1University of Florida, Department of Chemistry & Quantum Theory

2:45 PM – 3:00 PM

3:00 PM – 3:20 PM

Project, Gainesville, FL

“Controlled Synthesis Of A Water‐Soluble Hyperbranched Polymer As A Transporter For Anticancer Drugs” Melody N. Gibson, and Darlene K. Taylor* North Carolina Central University, Department of Chemistry, Durham, NC

“Preliminary Molecular Dynamic Simulations Of The Estrogen Receptor From Antagonist To Agonist” T. Dwight McGee1, Jesse Edwards1, Adrian E. Roitberg2 1Department of Chemistry, Florida A & M University, Tallahassee, FL 2Department of Chemistry and Quantum Theory Project, University of Florida, Gainesville, FL

18

PROGRAM SCHEDULE Technical Session 5 3:45 PM – 5:45 PM Nanotechnology Applications I (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation

Monday, PM

Room 410

3:45 PM – 4:15 PM

4:15 PM – 4:30 PM

4:30 PM – 4:45 PM

Highlighted Speaker “Polymer/LC Dynamic Gratings” Timothy J. Bunning Air Force Research Lab, MLPJ, WPAFB, OH

“New Approaches For Size‐ And Shape‐Controlled Ruthenium Nanoparticles” Ruel G. Freemantle and Sherine O. Obare University of North Carolina – Charlotte, Department of Chemistry and the Nanoscale Science PhD Program, Charlotte, NC

“Deactivation Of Ms2‐Coliphage With Nanostructured Ta2O‐SiO2” William N. Harris III*1, Nicholas Ndiege2, Ramesh Chandrasekharan3, Sharifeh Mehrabi4, Mark A. Shannon3, Thanh H. (Helen) Nguyen5, Eric A. Mintz4

4:45 PM – 4:50 PM

4:50 PM – 5:05 PM

1Morehouse College, Department of Chemistry, Atlanta, GA 2 Department of Chemistry University of Illinois at Urbana‐Champaign, Urbana, Illinois 3 Department of Mechanical and Industrial Engineering University of Illinois at Urbana‐Champaign, Urbana, Illinois 4 Clark Atlanta University, Department of Chemistry, Atlanta, GA 5 Department of Civil and Environmental Engineering University of Illinois at Urbana‐Champaign, Urbana, Illinois

Break

“Microwave Synthesis And AFM Characterizations Of Iron(III)‐Nickel Nanoparticles” Algernon T. Kelley, Nickolaus Flurry and Jayne C. Garno* Department of Chemistry and the Center for Biomodular Multi‐Scale Systems Louisiana State University, Baton Rouge, LA

19

PROGRAM SCHEDULE 5:05 PM – 5:20 PM

“Characterizing Functionalized Carbon Nanotubes Using Qualitative Analysis” Tiffany N. Taylor1, Derrick R. Dean2, Pamela M. Leggett‐Robinson*1 1Tuskegee University, Department of Chemistry, Tuskegee, AL; 2Univeristy of Alabama‐Birmingham, Department of Materials Science and Engineering, Birmingham, AL

Monday, PM

Technical Session 6 3:40 PM – 5:30 PM Bioapplications in Materials Chemistry (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation

Room 411

3:40 PM – 4:20 PM

4:20 PM – 4:35 PM

Highlighted Speaker “Polyester And Polyester Urethane Based Biomaterials” Valerie S. Ashby University of North Carolina at Chapel Hill, Department of Chemistry Chapel Hill, NC

“Synthesis And Characterization Of Novel Nano‐ And Micro‐ Particles” Aaron Tesfai1, Bilal El‐Zahab1, David Bwambok1, Hadi M. Marwani1, Gabriela Ganea1, Gary A. Baker2, Sayo O. Fakayode3, Mark A. Lowry1, and Isiah M. Warner*1 1 Department of Chemistry, Louisiana State University, Baton Rouge, LA 2 Oak Ridge National Laboratory, Oak Ridge, TN 3 Department of Chemistry, Winston‐Salem State University, Winston‐ Salem, NC

4:35 PM – 4:50 PM

“Surface Functionalized Biopolymers For Phosphate Removal In Patients With End Stage Renal Disease (ESRD)” Anika A. Odukale*1, Christopher D. Batich 1Materials Science and Engineering, the University of Florida,

4:50 PM – 4:55 PM

Gainesville, FL

Break 20

PROGRAM SCHEDULE

4:55 PM – 5:05 PM

Poster Talk “An Examination Of Binding Energies In Biologically Relevant Systems Using Chemical Microscopy Of Protein Surfaces” Chanel C. King, Dr. Carl Bonner*, and Dr. Katina Patrick Center for Materials Research and Department of Chemistry, Norfolk State University, Norfolk, VA

“Designing Macromolecules With Strong Similarities To Biology” Gregory N. Tew Department of Polymer Science and Engineering, University of Massachusetts‐Amherst, 120 Governors Drive, Amherst, MA

5:05 PM – 5:30 PM

Monday, PM

Host Chapter Reception ‐ Delaware Valley Chapter’s 25 Anniversary Celebration 6:00 PM ‐ 8:00 PM

Salon H

10:00 PM – 12:00 AM

Hospitality Room

Salon H

Tuesday

April 3

Technical Symposium ‐ The Johns Hopkins University Applied Physics Laboratory

7:00 AM – 8:00 AM

Tuesday, AM

NPC Committee Meeting

Teachers Workshop 7:00 AM ‐ 5:00 PM

“Achieving Science Through Education”

Room 413

Salon IJ

Sponsored by 3M, AAAS, Roche Pharmaceuticals, and Committee for Action Program Services

Moderator

Mrs. Linda Davis, Committee Action Program Services Cedar Hill, TX

7:00 AM – 8:45 AM 8:00 AM – 8:45 AM

Registration Continential Breakfast

21

PROGRAM SCHEDULE 8:45 AM ‐ 9:00 AM

Welcome and Opening Remarks Mrs. Linda Davis, Director, Committee Chairperson and Moderator Dr. Victor McCrary, President National NOBCChE

9:00 AM ‐ 12:00 N

ʺInspire Students to Excel at Science by Unveiling the Learning Process!ʺ Dr. Saundra McGuire, Director of Center for Academic Success, Adjunct Professor of Chemistry, and Associate Dean of University College at Louisiana State University, Baton Rouge, LA Break Lunch

10:00 AM – 10:15 AM 12:00 N – 1:30 PM 1:00 PM – 2:30 PM

“Sustainability Chemistry: Biodiesel Introduction” Ms. Jennifer Stimpson, Educator, Innovator and Scientist Yvonne A. Ewell Townview Center, Dallas, Texas

2:45 PM – 4:15 PM

“Enhancing Teaching and Learning in the Science Classroom Using Data Collection Technology” Mr. Michael L. Osborne Market Strategy Manager,Texas Instruments, Education Technology , Dallas, Texas

Expanded Coffee Service

7:30 AM – 9:00 AM

Sponsored by Howard University Chemistry Department

Franklin Foyer

8:00 AM ‐ 4:00 PM

Conference Registration

Franklin Foyer

Plenary II ‐ Nanotechnology in Chemistry Franklin 1 Symposium 8:30 AM ‐ 9:30 AM

Dr. Chekesha Liddell Chemical Engineering Department, Cornell University

Tuesday, AM

22

PROGRAM SCHEDULE Technical Session 7 9:45 AM – 11:45 AM Biofuels: Opportunities, Challenges and Technology Development (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation

Tuesday, AM

Room 411

9:45 AM – 10:15 AM

10:15 AM – 10:30 AM

Highlighted Speaker “Biofuels: Opportunities, Challenges and Technology Development” Foster A Agblevor Department of Biological Systems Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA

“The Potential Impact Of Invasive Aquatic Plants On The Sustainable Production Of Cellulosic Ethanol” Lealon L. Martin*1 1Rensselaer Polytechnic Institute, Howard P. Iserman Department

10:30 AM – 10:45 AM

10:45 AM – 10:50 AM

10:50 AM – 11:05 AM

11:05 AM – 11:20 AM

of Chemical and Biological Engineering, Troy, NY

“Use Of Biomass/Coal Co‐Gasification Ash/Chars As Soil Amendments” Murphy J Keller, III*, Harry M. Edenborn, Ed Klunder and Dave Luebke U.S. Department of Energy, National Energy Technology Laboratory, (NETL) Pittsburgh, PA

Break

“Synthesis Of Biodiesel Via Ultrasound‐Enhanced Homogeneous And Solid Acid Catalyzed Processes – A Critical Review” Yusuf G. Adewuyi North Carolina Agricultural & Technical State University, Department of Chemical Engineering, Greensboro, NC

“Palm Oil‐Based Biodiesel: A High Oil Content Source Of Alternative Fuel” Emmanuel A. Dada FMC Corporation , P. O. Box 8, Princeton, NJ 23

PROGRAM SCHEDULE

“Kinetics Of Cellulose Hydrolysis In Supercritical And Subcritical Water” Kazeem B. Olanrewaju, Taiying Zhang, and Gary A. Aurand* The University of Iowa, Department of Chemical and Biochemical Engineering, Iowa City, IA

“Progress In Modeling Chemical Looping Combustion Systems” Isaac K. Gamwo1 and Jonghwun Jung2

11:20 AM – 11:35 AM

11:35 AM – 11:50 AM

1U.S. Department of Energy, National Energy Technology Laboratory, Pittsburgh, PA 2Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL Technical Session 8 9:45 AM – 11:45 AM Nanotechnology Applications 2 (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation

Tuesday, AM

Franklin 1

9:45 AM – 10:05 AM

“Investigation Of The Vibrational Response Of Individual Nanoparticles Using AFM With Magnetic Sample Modulation” Wilson K. Serem,1 Alessandro Varotto,2 Glenys Castro,1 C. Michael. Drain2 and Jayne C. Garno1* 1Department of Chemistry and The Center for BioModular Multi‐Scale Systems Louisiana State University, Baton Rouge, LA 2 The Graduate Center & Hunter College of The City University of

10:05 AM – 10:25 AM

New York, Department of Chemistry & Biochemistry, 695 Park Avenue, New York, NY and The Rockefeller University, 1230 York Avenue, New York, NY

“Aerogel Synthesis” Nellone E. Reid*1, Jennifer Jolly 1Hampton University, School of Engineering and Technology,

Hampton, VA

24

PROGRAM SCHEDULE 10:25 AM – 11:05 AM

11:05 AM – 11:25 AM

11:25 AM – 11:45 AM

Highlighted Speaker “Functional Thin Film Polymer Surfaces” Damla Koylu, Janet A. Maegerlein and Kenneth R. Carter Polymer Science and Engineering Department, University of Massachusetts – Amherst Amherst, Massachusetts

“Atomistic Simulation Of Tensile Behavior Of Graphene Polypropylene Nanocomposites” Rozlyn N. Chambliss and Melissa S. Reeves* Tuskegee University, Department of Chemistry, Tuskegee, AL

“Photopolymerization Kinetics Of Binary Thiol‐acrylate Nanocomposites” Kwame Owusu‐Adom and C. Allan Guymon* Department of Chemical & Biochemical Engineering, University of Iowa, Iowa City, IA

Technical Session 9 9:45 AM – 11:45 AM Physical Chemistry (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation

Tuesday, AM

Room 412

9:45 AM – 10:05 AM

“High‐Accuracy Ab Initio Studies Of Tetrasulfur Energetics” John A.W. Harkless*1 and Joseph S. Francisco2 1Department of Chemistry, Howard University, Washington, DC ; 2Department of Chemistry and Department of Earth & Atmospheric

10:05 AM – 10:20 AM

10:20 AM – 10:35 AM

Sciences, Purdue University, West Lafayette, IN

“Infrared Optical Absorption of Divalent Lead Pb(II) Complexes from First Principles” Heng Li, Vladimir I. Gavrilenko Center for Materials Research, Norfolk State University, 700 Park Avenue, Norfolk, VA

“Nonlinear Optical Studies Of Specific Solvation Across Liquid Interfaces” A. Renee Siler*, Michael R. Brindza, and Robert A. Walker University of Maryland, Department of Chemistry and Biochemistry, College Park, MD 25

PROGRAM SCHEDULE 10:35 AM – 10:40 AM 10:40 AM – 10:55 AM

10:55 AM – 11:10 AM

11:10 AM – 11:25 AM

11:25 AM – 11:40 AM

11:40 AM – 11:45 AM

Break “Electron Transfer Between Size Quantized Cdse And TiO2 Using Bifunctional Linkers In Reversed Micelles” Clifton T. Harris University of Notre Dame, Radiation Laboratory, Notre Dame, IN

“Interfacial And Thermodynamic Phenomena Related To A Novel Liquid/Liquid Extraction Process For Solvents With A Small Density Difference” Nicole James, Filomena Califano* Chemistry and Physics Department, St. Francis College, Brooklyn Heights, NY “An AB Initio Study Of The Electronic Excited States, N2 And O2, Using Quantum Monte Carlo Methods” Floyd A. Fayton Jr*, and John A.W. Harkless Department of Chemistry, Howard University, 525 College St., NW, Washington, DC

“The Time Dependence Of The Changes In The Emission Spectrum Of Comet 9P/Temple 1 After Deep Impact” William M. Jackson*, XueLiang Yang1, and Anita L. Cochran2

1 Department of Chemistry, University of California, 1 Shields Avenue, Davis, CA 2Department of Astronomy and McDonald Observatory, University of Texas at Austin, C‐1400, Austin, TX

Poster Talk “Physical Characterization Of Spectroscopic Methods: Mass Spectroscopy” Steven M. Cannon Chemistry Department , University of Illinois at Chicago, Chicago, Illinois

Tuesday, PM

Percy L. Julian Symposium Luncheon 12:00 PM ‐ 1:30 PM

Salon H……..

Speaker – Dr. Sharon Haynie, DuPont Company (ticketed)

26

PROGRAM SCHEDULE

NOBCChE ‐ Rohm and Haas

Undergraduate Research Competition Franklin 1……

1:45 – 3:45 PM Mr. Vere O. Archibald, Rohm and Haas Company Marlon Walker, National Institute of Standards and Technology Presenters TBA

Tuesday, PM Moderator

Tuesday, PM

Graduate Students Shoppers Delight: GEM

Informational Session and Graduate Room 411 School Survival Tips 1:45 P.M. – 3:30 P.M.

“How To Be Successful In Graduate School: Understanding Graduate School Lingo”

Sibrina Collins, University of Washington, Grad. School, Seattle, WA and Marcus Huggans, The National GEM Consortium, Washington, DC

Presenters:

9:00 AM ‐ 4:00 PM

Career Fair Setup for Exhibitors

Franklin B

Technical Session 10 1:45 PM – 3:30 PM Graduate Students Sci‐Mix Symposium (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation

Tuesday, PM

Room 412

1:45 PM – 2:05 PM

Dow Chemical Company Fellowship Awardee “Synthesis and Processing Of Silver Nanoparticles Through The Use Of CO2‐ Expanded Liquids” Gregory Von White II*1, Christopher L. Kitchens1 1Clemson University, Department of Chemical and Biomolecular Engineering,

2:05 PM – 2:25 PM

Clemson, SC

Eastman Kodak Dr. Theophilus Sorrell Fellowship Awardee “The Influence Of Gestation And Lactation Stage On The Peptide Profile Of Human Milk” Kirsten Jeffries‐Grant*1, Randolph L. Rill2, Doris Terry2, Jeremiah Tipton3 27

PROGRAM SCHEDULE 1The Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 2The College of Medicine, Florida State University, Tallahassee, FL 3 The National High Field Magnet Laboratory, Florida State University,

2:25 PM – 2:45 PM

Tallahassee, FL

E.I. Dupont Fellowship Awardee “In Vitro Oxidative Folding Partners: Studying the Cooperation of Quiescin Sulfhydryl Oxidase (QSOX) and Protein Disulfide Isomerase (PDI)” Pumtiwitt C. Rancy*1, Jakob R. Winther2, Colin Thorpe1 1University of Delaware, Department of Chemistry and Biochemistry, Newark, DE 2University of Copenhagen, Department of Molecular Biology, Copenhagen,

2:45 PM – 3:05 PM

Denmark

Procter and Gamble Fellowship Awardee “Analysis Of Pesticides In Hair By Comprehensive Two‐Dimensional Gas Chromatography” Charlotte A. Smith‐Baker*1, Mahmoud A. Saleh1, and J.‐M. D. Dimandja2 1Texas Southern University, Department of Chemistry, Houston, TX 2Spelman College, Department of Chemistry, Atlanta, GA

3:05 PM – 3:25 PM

Lendon N. Pridgen, GlaxoSmithKline ‐ NOBCChE Fellowship Awardee “Total Synthesis of Phomopsins” Brandon T. Kelley and Madeliene Joullie Department of Chemistry, University of Pennsylvania, Philadelphia, PA

Tuesday, PM

Presenter:

Next Generation Process Automation at The Dow Chemical Company: The Journey to Room 413 Commercial Solutions 3:00 P.M. – 5:00 P.M.

Eric Cosman, Engineering Solutions, The Dow Chemical Company

28

PROGRAM SCHEDULE

Tuesday, PM Moderator: Presenters:

Plenary III ‐ Health Symposium 4:00 PM ‐ 6:00 PM Salon G “AIDS/HIV Updates” sponsored by Eli Lilly Company Dr. Ronald D. Lewis, II, Chair, 2008 NOBCChE Health Symposium Dr. Gail H. Cassell, Vice President, Scientific Affairs, Infectious Diseases, Eli Lilly and Company, Indianapolis, IN. Mr. Gary J. Bell, MSW, LCSW, BCD, (Private Practice) Plymouth Meeting, PA Dr. Carol Germaine, Biology Program Manager, R&D Informatics, Pfizer, La Jolla, CA. Dr. Pamela A. Clax, (Private Practice) Plymouth Meeting, PA Dr. Arlene Bardeguez, Professor of Obstetrics & Gynecology, University of Medicine and Dentistry of New Jersey, Newark, NJ.

Questions and Answers Open to the Floor

Closing Remarks

Dr. Ronald D. Lewis, II

6:00 PM ‐ 8:00 PM

Exhibitorʹs Welcome Reception sponsored by University of Maryland College Park

Salon H

10:00 PM – 12:00 AM

Hospitality Room

Salon H

Wednesday

7:00 AM ‐ 7:30 AM

Wednesday, AM

March 19

NPC Committee Meeting

Room 402

Teachers Workshop II Salon IJ 7:00 AM ‐ 5:00 PM

“Achieving Science Through Education”

Sponsored by 3M, AAAS, Roche Pharmaceuticals, and Committee for Action Program Services

Moderator

Mrs. Linda Davis, Committee Action Program Services Cedar Hill, TX

7:00 AM – 8:45 AM

Registration 29

PROGRAM SCHEDULE 8:00 AM – 8:45 AM 8:45 AM ‐ 9:00 AM

Continential Breakfast Opening Remarks Mrs. Linda Davis, Director, Committee Chairperson and Moderator

9:00 AM ‐ 11:45 AM

“African Foundations Of Western Math, Science And Technology In The Global Context Of Five River Civilizations”

Dr. James Grainger, Analytical/Environmental Chemist Center for Disease Control and Preventive, Atlanta, Georgia

Break Lunch “Integrating Tools for Hands‐on Teaching in the Classroom” K‐12

Yolanda George AAAS, Washington, DC

10:00 AM – 10:15 AM 12:00 N – 1:30 PM 1:00 PM – 4:00 PM

7:30 AM ‐ 9:00 AM Presenter:

Plenary IV ‐ Jumpstarting Your Career & Breakfast (ticketed)sponsored by Rohm and Salon H Haas Corporation Ms. Cathie Markham, Vice President of Technology and Chief Technology Officer, Rohm and Haas Company

“Finding Your Passion!”

8:00 AM ‐ 4:00 PM

Conference Registration

Franklin Foyer

9:00 AM ‐ 6:00 PM

CAREER FAIR EXPO

Franklin B

30

PROGRAM SCHEDULE

Wednesday, AM

You Donʹt Know What You Donʹt Know: Emotional Intelligence 8:00 AM ‐ 5:00 PM

Room 411

Wednesday, AM

Managing an Effective Job Search sponsored by ACS 9:00 AM ‐ 11:00 AM

Room 412

Our Chemistory: Celebrating Our History in Wednesday, AM the Chemical Sciences Franklin 1 10:00 AM ‐ 11:00 AM

Dr. Sibrina Collins, Graduate School, Univewrsity of Washington Presenters: Dr. Anthony Dent, Cheyney University of Pennsylvania

LUNCH ON YOUR OWN

ACS ‐ Leading Change Wednesday, PM

(Pre‐registration required) 2:00 PM ‐ 5:00 PM

Room 412

Wednesday, PM

NSF and DOD Fellowship Informational Session 2:00 PM 3:30 PM

Room 415

Presenter

Mr. Tim Turner, ASEE Program Director, NSF Graduate Research Fellowships.

31

PROGRAM SCHEDULE

5:30 PM – 8:30 PM

National Science Competition Registration and Opening Session

Wednesday, PM

NOBCChE Scientific Exchange Poster Session 5:00 – 7:00 PM

1

2

3

Salons G

Franklin A

“Ruthenium Oxide/Silica Composites As Novel Platform For Carbon Monoxide Gas Sensing” Adedunni D Adeyemo*1, Prabir K Dutta1 The Ohio State University, Department of Chemistry, Columbus, OH “Ostwald Ripening at the Single Droplet Level” Malcolm Mathis Department of Chemistry, Kent State University, Kent Ohio

“Optimization of Lignin Degradation Components by Capillary Electrophoresis‐Mass Spectrometry” Roderquita K. Moore1,2, William Bragg3, Cass Parker1, Shahab A. Shamsi3* 1Department of Chemistry, Clark Atlanta University, Atlanta, GA 2USDA Forest Service, Forest Products Laboratory, Madison, WI 3Department of Chemistry, Center of Biotechnology and Drug Design

4

5

6

Georgia State University, Atlanta, GA

“Carbohydrate Structural Determination Using Mass Spectrometry” Aleeta M. Powe University of Louisville, Louisville, KY

“Application Of Ratiometric Spectral Properties Of Salicylidene Derivatives In The Analysis Of Selected Anions” Dharendra Thapa, Richard Williams* Morgan State University, Chemistry Department , Baltimore, MD

“Mediator‐Less Amperometric Biosensors For Phenols Based On Immobilized Tyrosinase In Chitosan Film” Yanique Thomas, Dr. Yongchao Zhang* Morgan State University, Chemistry Department, Baltimore, MD

32

PROGRAM SCHEDULE 7

8

“Evaluation Of The Precision And Accuracy Of Laser Ablation ICP‐MS As A Rapid Method For Trace Element Analysis Of Modern Sediments” Marvourneen K. Dolor1*, William F. McDonough2 and George R. Helz1, 2 1Department of Chemistry and Biochemistry, 2Department of Geology University of Maryland, College Park MD “Optical Sensors For The Selective Detection Of Organophosphorus Pesticides” Tova A. Samuels1, Chandrima De2, Desmond H. Murray3, and Sherine O. Obare*4 1University of North Carolina at Charlotte, Department of Chemistry, Charlotte, NC 2Department of Chemistry, Western Michigan University, Kalamazoo, MI 3Department of Chemistry and Biochemistry, Andrews University, Berrien Springs, MI 4University of North Carolina at Charlotte, Department of Chemistry and the

9

10

11

Nanoscale Science PhD Program, Charlotte, NC

“Cyanine Sensors Monitor The Degree Of Flavinoid Protection Against Endotoxin‐Induced Fetotoxicity” Evelyn Ntam, Tricia Charles, Roxanne Howell, Michael Baker, Carroll Reese, Tanika Martin and Dwayne Hill* Morgan State University, Department of Biology, Baltimore, MD

“An Investigation Of The Use Of Chitosan As A Substitute For 3‐(Amino‐ Propyl) Triethoxysilane (Aps) In The Fabrication Of Glass Surfaces For Use As Substrates In Metal Enhanced Fluorescence Techniques” Ichhuk Karki*, Richard Williams Morgan State University, Department of Chemistry, Baltimore, MD

“Prospective Usefulness Of Cyanine Sensors To Indicate If PCB‐Challenged Progenitor Cells Can Produce Regulatory Factors For Macrophages” Oluwafadekemi Adedayo, Courtney Fields, Tanika V. Martin, Carroll Reese, Dwayne Hill* Morgan State University, Department of Biology, Baltimore, Maryland

33

PROGRAM SCHEDULE 12

“The Preliminary Characterization Of Environmental Estrogens In Wastewater Effluents” Reba L. Scott*1, Katoria Tatum‐Gibbs2, Dr. Tuan Phan3, Dr. Renard L.Thomas3, Dr. Bobby Wilson3 1 Space Engineering, & Science Internship Program, Texas Southern University, Houston, TX 2 Environmental Toxicology PhD. Program, Texas Southern University, Houston, TX 3 NASA University Research Center, Texas Southern University, Houston, TX

13

“Alteration Of Neoplastic Cell Homeostasis By Cyanine Derivatives” Tolulope Ayangade1, Phillip Butler1, Michael Baker1, Colette Ntam1, Nicole Flemming2, Nikia Smith2, Devine Kebulu2, Angela Winstead2, Deshauna Curry2, Richard Williams2, Laundetta Jones3 and Dwayne Hill*1 Departments of Biology1 and Chemistry2, Morgan State University, Baltimore, Maryland, Department of Pharmacology and Experimental Therapeutics3,

14

University of Maryland, Baltimore, Maryland

“Quantifying Inorganic Contaminants In The Municipal Drinking Water Using ICP‐MS” Uchenna Obianagu1 , Andrea Oyewole2 , Felicia L. Conley3 , Renard L. Thomas3 , and Bobby L. Wilson3 1. Space, Engineering, & Science Internship Program, Texas Southern University, Houston, TX 2. Environmental Toxicology Ph.D. Program, Texas Southern University, Houston, TX 3. NASA University Research Center, Texas Southern University, Houston, TX

15

“Covalent Incorporation Of Imidazo[1,5‐A]Pyridine In Sol‐Gel Matrices And Their Application As Potential Chelating Ligands” Anastesia S. Lyons1, Roger Rowell2, Xiu Ren Bu*1 1Clark Atlanta University, Department of Chemistry, Atlanta, GA 2United States Department of Agriculture Forest Services, Madison, WI

34

PROGRAM SCHEDULE 16

“Synthesis And Application Of Redox Gradient Relay Molecules” Melody Kelley, Silas Blackstock* The University of Alabama, Department of Chemistry, Tuscaloosa, Al

17

18

19

20

21

22

“Synthesis And Characterization Of PTV‐Based Donor Polymers” Tanya David*, Cheng Zhang, Sam Sun, Rui Li Norfolk State University, Center for Materials Research Norfolk, VA

“Synthesis And Photophysical Characterization Of Schiff Bases As Anion Sensors” Belygona Barare, Dr Yousef Hijji* Morgan State University, Department of Chemistry, Baltimore MD

“Novel Porphyrin Tweezers For Absolute Stereochemical Determination Of Chiral Molecules” Dalila Davis*, Babak Borhan, Marina Tanasova Department of Chemistry, Michigan State University East Lansing, MI

“Synthesis And Photophysical Characterization Of 2‐Hydroxylnaphtalene‐1‐yl (Methylene) Hydrazinecarboxamide As An Anion Sensor” Oyebola A Oladeinde, Dr Yousef Hijji* Morgan State University, Department of Chemistry, Baltimore MD

“Titanium Catalyzed 3‐Component Coupling & Intramolecular Asymmetric Hydroamination Of Aminoalkenes” Kevin R. Gipson1, Aaron L. Odom*2, Supriyo Majumder3 Michigan State University , Department of Chemistry, East Lansing, MI

“Photo‐Physical Properties Of Nano‐Aggregates Of Oligomers Of MEH‐PPV” Gizelle A. Sherwood*1, Tim Smith1, Ryan Cheng1, Linda A. Peteanu1, J. Wildeman2.

1Department of Chemistry, Carnegie Mellon University, 4400 Fifth Ave, Pittsburgh, PA 2 Zernicke Institute for Advanced Materials, University of Groningen, Nijenborgh, Netherlands

35

PROGRAM SCHEDULE 23

24

25

26

“Physical Characterization Of Spectroscopic Methods: Mass Spectroscopy” Steven M. Cannon Chemistry Department ,University of Illinois at Chicago, Chicago, Illinois

“Dielectric Monitoring Of Epoxy Resins” Chidi S. Anyanwutaku, Dr. Alvin Kennedy* Morgan State University, Department of Chemistry, Baltimore, MD

“Microwave Heating Of Solvents At Subambient Temperatures” Emmanuel N. Dowuona, Dr. Alvin Kennedy* Morgan State University, Department of Chemistry, Baltimore, MD “Dynamics Of Fast Reactions In Ionic Liquids” Kandis Stubblefield1, Kathryn Sims1, Shawn M. Abernathy1, and James F. Wishart2 1Howard University, Department of Chemistry, Washington, DC 2Brookhaven National Laboratory, Upton, NY

27

28

29

30

“Effect Of Concentration Of Titanium Dioxide Scatterers In A Solid State Random Laser” John Kibet Kitur* Norfolk State University, 700 Park Ave., Norfolk, VA

“Fabrication Of 3d‐PPA’s Of Hexagonal Ag Pattern On The Substrate Mica Utilizing AFM & NSOM” Eric J. Robinson*& Dr. Carl E. Bonner Norfolk State University, Center for Materials Research, Norfolk, Virginia

“Silylamides Of Ga And In For Use In The MOCVD Of Metal Nitrides” Felicia A. McClary, Jason S. Matthews Howard University, Department of Chemistry

“Influence Of Conductive Carbon On Properties Of Solution Cast SBS‐ Polyaniline Composite Films” Yunus Balogun and R.C. Buchanan University of Cincinnati, Dept. of Chemical and Materials Engineering, Cincinnati, OH

36

PROGRAM SCHEDULE 31

32

“Polymerization Of Nanocomposites” Abisola B. Ajayi, Dr. Alvin Kennedy* Morgan State University, Department of Chemistry, Baltimore MD

“The Thermal And Exfoliation Properties Of Nanocomposites And Thermosets At Different Reaction Ratios” Racquel Jemison1, Solomon Tadesse1, Dr. Alvin P. Kennedy1*, Dr. Eugene Hoffman2, 1Morgan State University, Department of Chemistry, Baltimore, MD 2Morgan State University, Department of Physics, Baltimore, MD

33

34

35

36

37

“Heating Profiles Of Microwave Irradiated Emulsions” Sarah A. Addae, Dr. Alvin P. Kennedy* Morgan State University, Chemistry Department, Baltimore, MD

“Modeling Excitations Energies Of Phenylene‐Vinylene Oligomers For Solar Cell Materials” LaTonya, Renee, Waller*; Suely, M, Black Norfolk State University, Center for Materials Research Norfolk, VA

“Novel Nanomaterials Based On Gold Nanorods And A Thermally‐Responsive Polymer” Fedena Fanord, Cecil Coutinho, David Walker, and Vinay K. Gupta* University of South Florida, Department of Chemical Engineering, Tampa, FL

“Synthesis And Magnetic Characterizations Of Manganite‐Based Composite Nanoparticles For Biomedical Applications” Kai Zhang*, H. Mustafa, L. R. Waller, A. K. Pradhan Center for Materials Research, Norfolk State University, Norfolk, VA

“Affect Of Superparamagnetic Iron Oxide Agents On NMR And Spin Relaxation In Biological Environments” Tracee Weaver *, Roselyn Obasi, Dr. Natalia Noginova Norfolk State University, Center for Materials Research, Norfolk, VA

37

PROGRAM SCHEDULE 38

“Carbon Nanotube Versus Carbon Black‐Filled Epoxy For Electrical Conductivity” Karen R. Petty*1,2, Matt Weisenberger1, R. Andrews1 1Center for Applied Energy Research, University of Kentucky, Lexington, KY 2Department of Chemical and Materials Engineering, University of Kentucky,

39

Lexington, KY

“Synthesis And Characterization Of Some Fluorine‐Containing Complexes Of Ruthenium(II)/Platinum(II): Use Of 19F NMR In Studying DNA Interactions” Lamaryet Moody1, Robert Johnson1, Luke Seymour1, Varma H. Rambaran2, Woodrow Ward1, Eva Clark1, Don vanDerveer3, William Jarrett1, and Alvin A. Holder*1 1Department of Chemistry and Biochemistry, The University of Southern Mississippi, Hattiesburg, MS 2The University of Trinidad and Tobago, OʹMeara Campus, Lots 74‐98, OʹMeara Industrial Park, Arima, Trinidad and Tobago 3Chemistry Department, Clemson University, Clemson

40

41

42

“Olefin Oligomerization And Polymerization Behavior Of New Titanium‐Based Catalysts Bearing Thiolate Or Phenolate Ligands With Pendant π‐acidic Phosphine Groups” Leon Dyers Jr., Richard Eaves, Sean Parkin, and Folami T. Ladipo* Department of Chemistry, University of Kentucky, Lexington, KY

“Research Opportunities At The University Of Kentucky” Leon Dyers Jr. and Folami T. Ladipo* Department of Chemistry, University of Kentucky, Lexington, KY

“Polyelectrolyte Multilayer Coatings With Molecular Micelles In Open Tubular Capillary Electrochromatography” Candace A. Luces1, Sayo O. Fakayode2, Mark Lowry1, Isiah M. Warner1* 1Department of Chemistry, Louisiana State University, Baton Rouge, LA 2Department of Chemistry, Winston‐Salem State University, Winston‐Salem, NC

38

PROGRAM SCHEDULE 43

“Investigation Of Enantiomeric Recognition Using Chiral Ionic Liquids Derived From Amino Acid Esters By Spectroscopy” David K. Bwambok1, Hadi M. Marwani1, Vivian E. Fernand1, Sayo O. Fakayode2, Mark Lowry1, Bilal El‐Zahab1, Gary A. Baker3, Ioan Negulescu1, Robert M. Strongin4, and Isiah M. Warner1 1Department of Chemistry, Louisiana State University, Baton Rouge, LA 2Department of Chemistry, Winston‐Salem State University, Winston‐Salem, NC 3Chemical Sciences Division, Nanomaterials Chemistry Group, Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, TN 4Department of Chemistry, Portland State University, Portland, OR

44

“Analysis Of CD24 Glycans By MALDI‐TOF‐MS Reveals Prevalence Of Sialosly‐T Antigen” Edwin Motari*I, Xincheng ZhengII, Yang LiuIII, Mamuka KvaratskheliaIV, Michael FreitasV, Peng G. WangI I Departments of Chemistry and Biochemistry, The Ohio State University, Columbus, OH IIOncoImmune, Inc. Columbus, OH III Department of Surgery and Internal Medicine, University of Michigan, Ann Harbor, MI IV Center for Retrovirus and Comprehensive Cancer Center, College of Pharmacy, The Ohio State University, Columbus, OH V Department of Molecular Virology, Immunology & Medical Genetics, School of

45

Biomedical Science, College of medicine, The Ohio State University, Columbus, OH

“Investigating The Thermodynamics And Kinetics Of The Alpha‐1,4‐ Galactosyltransferase‐Catalyzed Reaction Of UDP‐Galactose And Lactose” Kaarina Lokko* and Peng George Wang The Ohio State University, Department of Chemistry, Columbus, OH

39

PROGRAM SCHEDULE 46

“Direct Analysis Of Amino Acids In Tobacco Products By Liquid Chromatography Tandem Mass Spectrometry” Kouassi Ayikoe*1, Dawit Z. Bezabeh, Ph.D2, Folahan O. Ayorinde, Ph.D.1, and Md Abdul Mabud, Ph.D.2 1Department of Chemistry, Howard University, Washington DC 2Department of Treasury, Alcohol and Tobacco Tax and Trade Bureau (TTB); 6000

47

Ammendale Road, Ammendale, MD

“Identification Of Immune Related Proteins From The American Alligator (Alligator Mississippiensis) Using 2D‐Gel Separation And Mass Spectrometry” Lancia N.F. Darville*1, Mark E. Merchant2 and Kermit K. Murray1 1Louisiana State University, Baton Rouge, LA and 2McNesse State University,

48

49

Lake Charles, LA

“Nucleotide Ion Exchange With Surface‐Confined Ionic Liquid Stationary Phases” Patrice R. Fields* and Apryll M. Stalcup Department of Chemistry, University of Cincinnati, Cincinnati, OH

“Spatial And Fluorescence Multiplexing For High‐Throughput Single Molecule Detection”

50

51

Paul I. Okagbare*, and Steven A. Soper Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana

“Functional Screening Of Membrane Proteins Expressed In Glioma Cell Lines Using Frontal Affinity Chromatography” Harrison K. Musyimi, Ruin Moadel, Chester R. Frazier and Irving W. Wainer National Insitute on Aging, National Institutes of Health, Gerontology Research Center 5600 Nathan Shock Drive, Baltimore, MD

“Investigation Of Ruthenium Complexes And Heptamethine Cyanine Near‐ Infrared Fluorophores As Donor/Acceptor Groups For Fluorescence Resonance Energy Transfer (FRET) Analysis” Isha Pradhan, Maurice Iwunze, Richard Williams* Morgan State University, Department of Chemistry, Baltimore, MD

40

PROGRAM SCHEDULE 52

“The Effect Of Inositol Hexaphosphate (IP6) On The Proliferation Of The Frog Renal Adenocarcinoma PNKT‐4B Cell Line” Michael Henderson*2, Nichole L. Powell1 and Roberta M. Troy2

53

Departments of Chemistry1 and Biology2, Tuskegee University, Tuskegee, AL

“Proteomics Analysis Of An APP/PS‐1 Mouse Model Of Alzheimers Disease” Rukhsana Sultana*1, Renã A. Sowell1, D. Allan Butterfield1 1 Department of Chemistry, University of Kentucky, Lexington, KY

54

55

56

“Molecular Dynamic Simulations Of The HIV Protease Subtype C” T. Dwight McGee1, Jesse Edwards1, Adrian E. Roitberg2 1Department of Chemistry, Florida A & M University, Tallahassee, FL 2Department of Chemistry and Quantum Theory Project, University of Florida, Gainesville, FL

“In Vitro Damage Of Naked DNA Upon Exposure To Environmental Factors” Tracie E. Perkins, Martha S. Johnson, Ebony Griffin, and Naomi Campbell* Jackson State University, Jackson, MS

“Structural Investigation And Molecular Simulations Of Native And Mutated Spliceosomal U2 snRNA‐Intron Helices: Detection Of Conformational Changes And The Importance Of An RNA Base Triple In The Spliceosomal Core” Joycelynn D. Nelson1,4, Donghong Min3, Jiang Shao1,2 and Wei Yang*1,2,3 1Department of Chemistry and Biochemistry, The Florida State University, Tallahassee, FL 2Institute of Molecular Biophysics, Department of Chemistry and Biochemistry, The Florida State University, Tallahassee, FL 3School of Computational Science, The Florida State University, Tallahassee, FL 4National High Magnetic Field Laboratory, 1800 E. Paul Dirac Drive, Tallahassee, FL

41

PROGRAM SCHEDULE 57

58

59

60

“An Isotope Dilution High Resolution Mass Spectrometry Method For Quantitative Measurement Of Isomeric Benzo[A]Pyrene Tetrol Metabolites Derived From Albumin‐Bapde Adducts As Indicators Of Human Exposure To Polycyclic Aromatic Hydrocarbons” Angela D. Ragin, Kenroy E. Crawford, Christopher Davies¹, James Grainger and Donald G. Patterson Jr National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Atlanta, Georgia ¹Western Kentucky University Department of Chemistry 1906 College Heights Blvd, Bowling Green, KY

“Elucidation Of The Roles For Arginine And Tyrosine In The DNA Binding Properties Of The NZF‐1 Zinc Binding Domains” Ieashia Starr Lewter*, Holly J. Cymet, PhD Department of Chemistry, Morgan State University, Baltimore, MD

“Signal Amplification By Redox Cycling At An Integrated Microelectrode Array In A Microchannel Device” Leethaniel Brumfield, III *, Penny Lewis, Emily Anderson, Dr. Ingrid Fritsch Department of Chemistry & Biochemistry, University of Arkansas, Fayetteville, Arkansas

“Unbiased Ligand Discovery For Histone Deacetylases Using Small Molecule Microarrays” Nicole M. Martinez*, Jason Fuller1, Angela N. Koehler1 1Broad Institute of MIT and Harvard, Chemical Biology Program, Cambridge, MA 2University of Puerto Rico, Department of Biotechnology, Mayaguez, PR

61

“Generation Of Stable Fluorescent Expression In Target Cells Used To Characterize Ex Vivo Cytolytic T Cell Function” Oluwadamilola T. Oladeru*1, Meghan Jendrysik2, Uimook Choi3 and Sharon Jackson4.

Molecular Trafficking Unit/ Lab of Host Defenses, National Institutes of Health, Institute of Allergy & Infectious Diseases, Bethesda

42

PROGRAM SCHEDULE 62

63

“Measurements Of Tissue Transglutaminase (tTg) Protein Concentration In Human Breast Cancer Cells” Reaya Richardson, Irine Chepkoech, Dr. Bassam Fraij Department of Biology, Chemistry and Environmental Health Science Benedict College, Columbia, SC

“A Computational Process To Locate IS Elements And Study Horizontal Gene Transfer In Bacterial Genomes” Walter J. Lewis*2, Wenyi Bi2, Sean R. McCorkle 1, Daniel Van DerLie1 1Brookhaven National Laboratory, Upton, NY 2Cheyney University of Pennsylvania, Cheyney, PA

64

65

“An Examination Of Binding Energies In Biologically Relevant Systems Using Chemical Microscopy Of Protein Surfaces” Chanel C. King, Dr. Carl Bonner*, and Dr. Katina Patrick Center for Materials Research and Department of Chemistry, Norfolk State University, Norfolk, VA

“Studies Toward The Synthesis Studies Of Spiroisoxazolines” Erick D. Ellis*, Jianping Xu, and Ashton T. Hamme Jackson State University, Department of Chemistry, Jackson, MS

66

67

68

“Synthesis And Characterization Of Water Soluble Monofuntional Pt(Ii) Complexes Useful For Biological Labeling” Margaret W. Ndinguri, Frank R. Fronczek, Robert P.Hammer and Luigi G. Marzilli* Department of Chemistry, Louisiana State University, Baton Rouge, LA

“Design & Synthesis Of Non‐Cyclic Imido‐Substituted 2‐Chloro 1,4‐ Naphthoquinone Derivatives As Mek1 Inhibitors And Potential Anticancer Agents” Yakini S. Brandy, and Oladapo Bakare* Department of Chemistry, Howard University, Washington, DC

“Efforts Toward The Synthesis Of (+)‐Kalkitoxin And Some Analogs” Adeleke A. Oni*, Everett W. Merling, and Richard J. Mullins Xavier University, Department of Chemistry, Cincinnati, OH

43

PROGRAM SCHEDULE 69

70

71

72 73

“Chemical And Pharmacological Studies Of A Plant Belonging To The Guttifereae Family: Mammea Africana” Ghislain Tchomobe* Department of Chemistry, University of Buea, P.O. Box 63, Buea, Cameroon

“Physical Characterization Of Chitosan Using Dilute Solution Viscometry” Abdul‐Rahman Raji, Alvin P. Kennedy* Morgan State University, Department of Chemistry, Baltimore, MD

“Shear And Elongational Rheology Of Membrane Dopes” Kayode O. Olanrewaju, Victor Breedveld* Georgia Institute of Technology, School of Chemical & Biomolecular Engineering, Atlanta, GA

‐‐ Withdrawn ‐‐

“The Bioeffects Of Metallized Nanotubes” Edidiong Obot *1, Prathyush Ramesh1, Renard Thomas2, Prabakaran Ravichandran3, Govindarajan Ramesh3, Bobby Wilson4 1Space, Engineering, and Science Internship Program (SESIP), Texas Southern University, Houston, Texas 2NASA University Research Center, Texas Southern University, Houston, Texas 3Molecular Neurotoxicology Laboratory, Texas Southern University Houston, Texas 4SESIP Program Director, Texas Southern University, Houston, Texas

74

“The Materials Research Facilities Network (MRFN), a National Research and Education Resource” Anika A. Odukale*1, Craig J. Hawker1, Timothy P. Lodge2, Thomas P. Russell3, Marek W. Urban4 1Materials Research Laboratory, University of California, Santa Barbara, CA 2MRSEC, University of Minnesota, Minneapolis, MN 3MRSEC on Polymers, University of Massachusetts, Amherst, MA 4Center for Response‐Driven Polymeric Films, the University of Southern Mississippi, Hattiesburg, MS

44

PROGRAM SCHEDULE 75

“Enhancing High School Chemistry Classes With Student Support” Edward D. Walton*1, Michael F. Z. Page1, Joelle Opotowsky1, Laurie Riggs1, and Brenda L. Olsen 1California State Polytechnic University, Pomona, CA 2Diamond Ranch High School, Pomona, CA

76

77

78

“Exciting Middle And High School Students In Chemistry Via Advances In Materials Science” Sherine O. Obare*, Tova A. Samuels and Ruel G. Freemantle *University of North Carolina at Charlotte, Department of Chemistry and the Nanoscale Science PhD Program Charlotte, NC

“Upgrading The Design Of A Traditional Physical Chemistry Laboratory Experiment: Determining The Heat Of Vaporization (∆Hvap) Of A Pure Liquid” Shawn M. Abernathy* and Anwar D. Jackson Howard University, Department of Chemistry, Washington, DC

“Poly(Anhydride‐Ester)/Antimicrobial Blends For Localized Drug Delivery” Michelle L. Johnson, Kathryn E. Uhrich* Rutgers, the State University of New Jersey, Department of Chemistry and Chemical Biology, Piscataway, NJ

7:00 PM ‐ Until

A NIGHT ON THE TOWN

10:00 PM ‐12:00 AM

Hospitality Suite

Salon H

Thursday,

March 20

7:00 AM ‐ 8:30 AM 7:00 AM ‐ 8:00 AM

NPC Committee Meeting Executive Board Meeting

Franklin 413 TBA

7:30 AM ‐ 9:00 AM

Plenary V ‐ State of the Organization ‐ A Roadmap Review

Salon G

8:00 AM ‐ 9:00 AM 8:00 AM ‐ 4:00 PM

Science Fair Setup Conference Registration

Franklin 1 & 2 Franklin Foyer

45

PROGRAM SCHEDULE

Technical Session 11 9:00 AM – 11:15 AM Lloyd Ferguson Young Scientist Award Symposium – Bioapplications in Organic Chemistry (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation

Thursday, AM

Room 410

9:00 AM – 9:30 AM

9:30 AM – 9:45 AM

Lloyd Ferguson Young Scientist Award Winner “Engineering Novel Hemoglobin‐Based Oxygen Carriers For Use In Transfusion Medicine” Andre F. Palmer Department of Chemical & Biomolecular Engineering, The Ohio State University, Columbus, Ohio

“Design And Synthesis Of Novel Hemoglobin Crosslinks Based On Phosphonate Mimics On 2, 3‐Bisphosphoglycerate” Tigist W. Kassa, Jason S. Matthews, Faith A. Brown

Department of Chemistry, Howard University, Washington, D.C.

9:45 AM – 10:00 AM “Synthesis of Ether Derivatives of (S)‐Nicotine” Pauline W. Ondachi and Daniel L. Comins* Department of Chemistry, North Carolina State University, Dabney Hall, Campus Box 8204, Raleigh, NC

10:00 AM – 10:10 AM Break

10:10 AM – 10:25 AM “The Development Of Anion Sensors And Their Characterization” Yousef Hijji*, Belygona Barare Chemistry Department, Morgan State University, Baltimore, MD

10:25 AM – 10:40 AM “Synthetic Studies On The Mdma (“Ecstasy”) Antagonist Nantenine” 1Onica Le Gendre, 2Stevan Pecic, 1‐3Wayne W. Harding*

1Department of Chemistry, Graduate Centre, CUNY, 365 5th Avenue, New York, NY 2Department of Biochemistry, Graduate Centre, CUNY, 365 5th Avenue, New York, NY 46

PROGRAM SCHEDULE 3 Department of Chemistry, CUNY, Hunter College, New York, NY

10:40 AM – 10:55 AM “Glucosamine Schiff Bases As Anion and Cation Sensors” Solomon Tadesse*, Yousef M. Hijji and Alvin P. Kennedy Morgan State University Department of Chemistry, Baltimore, MD

10:55 AM – 11:10 AM “Synthesis And Biological Evaluation Of Steroidal Based Aminoalkyloxy Derivatives Of Estrone As Potential Anti‐Breast Cancer Agents” Devora A. Simmons and John S. Cooperwood* College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, FL

Thursday, AM

Technical Session 12

9:00 AM – 11:00 AM Room 407 NOBCChE Professional Chemical

Engineering Award Symposium

(ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation

9:00 AM – 9:40 AM

NOBCChE Professional Chemical Engineering Awardee “Reducing The Rate Limiting Step In Chemical Engineering Growth” Christine S. Grant Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC

9:40 AM – 10:00 AM “Synthetic Biology: Potential and Implications of an Emerging Field” Michael Gyamerah* Prairie View A&M University, Department of Chemical Engineering, Prairie View, TX

10:00 AM – 10:20 AM “Non‐Catalytic Esterification Of Organic Acids In Supercritical Alcohol” Kehinde S. Bankole and Gary A. Aurand* The University of Iowa, Department of Chemical and Biochemical Engineering, Iowa City, IA 47

PROGRAM SCHEDULE

10:20 AM – 10:40 a.m “Social, Economic And Environmental Metrics For The SUSTAINABLE Optimization Of Chemical And Petroleum Processes” Karen A. High* and Olamide O. Shadiya Oklahoma State University, Department of Chemical Engineering, Stillwater OK

10:40 AM – 11:00 AM “Electrospinning” Tivern H. Turnbull Hampton University, Hampton, VA

Thursday, AM

9:00 AM – 9:20 AM

Technical Session 13 9:00 AM – 11:15 AM Analytical Chemistry

Room 406

“Analysis Of Trace Nickel At Iridium‐Based Ultramicroelectrode Arrays By Adsorptive Stripping Voltammetry” Joseph Wang*1, and Jiayang Wang2, and William K. Adeniyi3 1Director, Center for Bioelectronics and Biosensors, The Biodesign Institute, Arizona State University, Tempe, AZ 2Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM 3Department of Chemistry, North Carolina Agricultural and

9:20 AM – 9:40 AM

Technical State University, Greensboro, NC

“Metabolite Analysis Using Microfluidic Platforms” Gloria T. MaGee, Hui Chen* Xavier University of Louisiana, New Orleans, LA *Mississippi State University, MS State, MS

9:40 AM – 10:00 AM

“Characterization Of Self‐Assembled Monolayers That Resist Protein Adsorption Using Spectroscopic Ellipsometry” Marlon L. Walker1*, David J.Vanderah2, and Kenneth A. Rubinson3 1Surface and Microanalysis Science Division 2Biochemical Sciences Division 48

PROGRAM SCHEDULE National Institute of Standard and Technology, Gaithersburg, MD 3Department of Biochemistry and Molecular Biology, Wright State

10:00 AM – 10:05 AM

10:05 AM – 10:25 AM

University, Dayton, OH and Electronics and Electrical Engineering Laboratory, National Institute of Standard and Technology, Gaithersburg, MD

Break

“Research At The Savannah River National Laboratory; From The Laboratory To The Field And Back” Amy A. Ekechukwu Savannah River National Laboratory, Savannah River Site, Aiken, SC

10:25 AM – 10:45 AM “The Pros And Cons Of Analyzing A Metal Ion By UV‐VIS Vs. HPLC” Lamont Mckellar Emerson Resources 600 Markley Street Norristown PA

10:45 AM – 11:00 AM “A New Talent Of The Known Ionophore: Selective Recognition Of Thallium(I) By 1,3‐Alternate Calix[4]Arene‐Bis(Crown‐6)” Ebony D. Roper, Vladimir S. Talanov, Raymond J. Butcher, and Galina G. Talanova* Department of Chemistry, Howard University, Washington, DC

11:00 AM – 11:15 AM “Investigation Of Chemically Deposited Silver Films On Barium Titanate Beads As A Surface‐Enhanced Raman Scattering (Sers) Active Substrate For Detection Of Benzenethiol, 1, 2‐ Benzenedithiol, 1, 4‐Benzenedithiol, And Rhodamine 6G” Jonathan I. Onuegbu†, Anqie Fu‡, Orest Glembocki‡, Shaka Pokes‡, Dimitri Alexson‡, and Charles M. Hosten*† †Department of Chemistry, Howard University, Washington DC ‡Division of Electronics, Naval Research Laboratory, Washington DC

9:00 AM – 11:00 AM Science Fair Public Viewing 11:00 AM – 12:00 PM Science Fair Judging 49

Franklin 1 & 2 Franklin 1 & 2

PROGRAM SCHEDULE

Thursday, AM

Technical Session 14

11:30 AM – 1:00 PM Room 410 Bioapplications in Chemical Engineering

11:30 AM – 12:00 PM

Highlighted Speaker “Biocatalysis and Bioprocessing Under Extreme Conditions: Developing Sustainable Engineering Enhancements” Tonya L. Peeples Chemical and Biochemical Engineering, The University of Iowa Center for Environmentally Beneficial Catalysis Center for Biocatalysis and Bioprocessing

“Alternative Procedure To Control Pressure In The Microvasculature Of The Pallid Bat’s Wing” Vannard W. Davis*2, Bryan Jennings, Sam Mullins, LaShasta

12:00 PM – 12:20 PM

Robinson, Felecia M. Nave2, Christopher Quick1 1Texas A&M University REU Summer Program, College Station, TX 2Prairie View A&M University, Department of Chemical

12:20 PM – 12:40 PM

Engineering, Prairie View, TX

“Characterization Of Polymeric Microspheres Synthesized By Homogenization And Precision Fabrication” Devin Y. Brown, Kalena D. Stovall, Dr. Daniel W. Pack*

12:40 PM – 1:00 PM

Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana‐Champaign

“The Bioeffects of Metallized Nanotubes” Edidiong Obot *1, Prathyush Ramesh1, Renard Thomas2, Prabakaran Ravichandran3, Govindarajan Ramesh3, Bobby Wilson4 1Space, Engineering, and Science Internship Program (SESIP), Texas Southern University, Houston, Texas 2NASA University Research Center, Texas Southern University, Houston, Texas 3Molecular Neurotoxicology Laboratory, Texas Southern University, Houston, Texas 4SESIP Program Director, Texas Southern University, Houston, Texas 50

PROGRAM SCHEDULE

Technical Session 15 11:30 AM – 1:00 PM Organic Chemistry

Thursday, AM

11:30 AM – 11:50 AM

11:50 AM – 12:10 PM

12:10 PM – 12:30 PM

12:30 PM – 12:50 PM

Thursday, PM Moderators

Room 406

“Zr(IV)‐Catalyzed Tertiary Transamidation And Amide Metathesis Under Ambient Conditions” Nickeisha A. Stephenson, Samuel H. Gellman*, Shannon, S. Stahl* University of Wisconsin‐Madison, Madison WI

“Synthesis Of Sodium cis‐12,13‐epoxy‐cis‐9‐octadecenyl Sulfonate From Vernonia Oil” Nikki S. Johnson Department of Chemistry, Howard University, Washington, DC

“Design And Sythesis Of Low Band Gap Poly(Thienylene Vinylene‐S, S‐Dioxide‐Thienylenevinylene) For Optpelectronic Application” Thuong Nguyen *, Dr. Cheng Zhang , Dr. Sam Sun Norfolk State University, Center for Materials Research, Norfolk, VA

“The Synthesis Of Silylated 1,3‐Alternate Calixarenes” Prima R. Tatum, Paul F. Hudrlik, and Anne M. Hudrlik Department of Chemistry, Howard University, Washington, D. C.

Milligan Fellowship Session Room 411 12:00 ‐ 3:30 PM Dr. Janice Reutt‐Robey, University of MD, College Park, and Dr. Marlon L. Walker, National Institute of Standards & Technology

1:00 PM ‐ 5:00 PM

1:00 PM ‐ 5:00 PM

Senior Science Bowl 2

Franklin 9

1:00 PM ‐ 5:00 PM

Senior Science Bowl 3

Franklin 10

1:00 PM ‐ 5:00 PM

Junior Science Bowl 1

Franklin 11

LUNCH ON YOUR OWN

Senior Science Bowl 1

51

Franklin 8

PROGRAM SCHEDULE 1:00 PM ‐ 5:00 PM

Junior Science Bowl 2

Franklin 12

1:00 PM ‐ 5:00 PM

Junior Science Bowl 3

Franklin 13

1:30 PM ‐ 2:30 PM

2:30 PM – 4:00 PM

2:30 PM – 4:00 PM

Thursday, PM

Midwest Regional Meeting

Room 403

Northeast Regional Meeting

Room 406

Southeast Regional Meeting

Room 407

Southwest Regional Meeting

Room 410

West Regional Meeting

Room 413

LOCAL CHAPTER MANAGEMENT SESSION Chapter Presidents/Treasurer – Mandatory

Room 415

HBCU Presentation & Panel Discussion

Technical Session 16 3:00 PM – 5:00 PM Bioapplications in Analytical Chemistry

Franklin 7

Room 412

3:00 PM – 3:30 PM

Highlighted Speaker “In Situ Spectroscopy Of Operating Fuel Cells” Eugene S. Smotkin Department of Chemistry and Chemical Biology Northeastern University, Boston, MA

3:30 PM – 3:45 PM

“An Investigation Of Lysine Based Molecular Micelles As Coatings For Protein Separations In Open Tubular Capillary Electrochromatography” Leonard Moore Jr, Arther T. Gates, Candace Luces, Mark Lowry, and Isiah Warner* Louisiana State University, Chemistry Department, Baton Rouge, LA

52

PROGRAM SCHEDULE 3:45 PM – 4:00 PM

“Towards A Defined 3D Substrate For Controlling Human Embryonic Stem Cell Fate” Samira Musah1, Ratmir Derda1, and Laura Kiessling*1, 2 1University of Wisconsin‐Madison, Department of Chemistry, Madison, WI 2University of Wisconsin‐Madison, Department of Biochemistry,

4:00 PM – 4:15 PM

4:15 PM – 4:30 PM

Madison, WI

“Development And Characterization Of Near‐Infrared Fluorescent Probes For Applications As Chemical And Biological Sensors” Richard Williams, Yousef Hijji, Dwayne, Hill, Maurice Iwunze, Angela Winstead, Elizabeth Akapo, Ichhuk Karki, Divine Kebulu, Dharendra Thapa, and Isha Pradhan Morgan State University, Chemistry Department, Baltimore, MD

“Effect Of Cyanine Constructs On Transformed Cell Populations” Dwayne Hill*1, Tolulope Ayangade1, Phillip Butler1, Michael Baker1, Colette Ntam1, Nicole Flemming2, Nikia Smith2, Devine Kebulu2, Angela Winstead2, Deshauna Curry2, Richard Williams2 and Laundetta Jones3.

Departments of Biology1 and Chemistry2Morgan State University, Baltimore, Maryland. Department of Pharmacology and Experimental Therapeutics3, University of Maryland, Baltimore, Maryland

4:30 PM – 4:45 PM

“A Novel Method For Separation Of Globular Proteins By Use Of Polyacrylamide Gel Electrophoresis” Monica R. Sylvain*1, Emily Villar1, Sayo O. Fakayode2, Jessica Lee3, Bilal El‐Zahab1, Mark Lowry1, Jack N. Losso4, Isiah M. Warner1 1Department of Chemistry, Louisiana State University, Baton Rouge, LA 2Department of Chemistry, Winston‐Salem State University, Winston Salem, NC 3Department of Chemistry, Princeton University, Princeton, NJ 4Department of Food Science, Louisiana State University, Baton Rouge,

LA

53

PROGRAM SCHEDULE 4:45 PM – 5:00 PM

“Human Papilloma Virus (HPV): How Much Do We Know?”

Filomena Califano Chemistry and Physics Department, St. Francis College, Brooklyn Heights, NY

Technical Session 17 3:00 PM – 5:00 PM Materials and Polymer Chemistry

Thursday, PM

3:00 PM – 3:20 PM

3:20 PM – 3:40 PM

3:40 PM – 3:55 PM

3:55 PM – 4:05 PM

4:05 PM – 4:20 PM

Room 414

“Combinatorial Studies Of Surface Interactions In Block Copolymer Thin Films” Thomas H. Epps, III*, Julie N. Lawson, Thomas P. Scherr University of Delaware, Department of Chemical Engineering, Newark, DE

“Efficient Synthesis Of Regioregular Polythiophene Block Copolymers” Malika Jeffries‐EL, Michael Mitchell and Robyn Laskowski.

Department of Chemistry, Iowa State University, Ames, IA

“Surface Characterization Of Poly Methyl Methacrylate Microfluidic Channels” Talitha Hampton1 and Emanuel Waddell*2 Departments of 1Chemical Engineering and 2Chemistry, The University of Alabama in Huntsville Huntsville, AL

Break “INVESTIGATION Of The Dynamic Melt Rheology And Glass Transition Temperature Of GRC‐A Loaded With Zeolite L” T. Renee Brown1, Donald Hylton1, Eric A. Mintz1*, Conrad Ingram1, Joel Batson 1, Candace James1 and Kathy C. Chuang2

1Center for High Performance Polymers and Composites and Department of Chemistry, Clark Atlanta University, Atlanta, GA 2NASA Glenn Research Center, Cleveland, OH

54

PROGRAM SCHEDULE “Investigation Of The Physical Properties Of The Hybrid Hydroxyethyl Acrylate/Epoxide System For Controlled Physical Properties” Leroy Magowod, Jr*, Chris Coretsopoulos, and Alec Scranton University of Iowa, Department of Chemical and Biochemical Engineering Iowa City, Iowa

“Thermal And Mechanical Characterization Of Foam Core Containing POSS / Expandable Thermoplastic Microspheres” Wanda D. Jones, Vijaya K. Rangari*, and Shaik Jeelani

4:20 PM – 4:35 PM

4:35 PM – 4:50 PM

Tuskegee University Center for Advanced Materials (T‐CAM), Tuskegee, AL

6:00 PM ‐ 7:00 PM 7:00 PM ‐ 8:00 PM 8:00 PM ‐ 10:00 PM

Science Competition – Grand Master Hank Science Competition Dinner Science Competition Event

Salon H Salon H Salon H

7:00 PM ‐ 10:00 PM

Plenary VII ‐ Awards Ceremony & Gala Dinner

Special Guest: Bobbi Humphrey – First Lady of Flute

Salons G, K, L

10:00 PM – 12:00 AM

Hospitality Room

Salon H

Friday

March 21

Expanded Coffee Service

7:30 AM – 9:00 AM

Sponsored by Atlanta Metro Chapter and ACS Northeast Section

Franklin Foyer

8:00 AM – 11:30 AM 8:00 AM – 11:30 AM

Science Bowl Finals: Senior Division Science Bowl Finals: Junior Division

Franklin 2 Franklin 3

55

PROGRAM SCHEDULE

Friday, PM

3 PM – 5PM

Science Competition Awards Luncheon 11:30 AM ‐ 2:00 PM (ticketed) sponsored by Agilent Technologies

Salon H

Science Education Trip: The Franklin Institute Science Museum

56

NOBCChE 2008 EXHIBITORS

2008 Exhibitors 3M St. Paul, MN Abbott Laboratories Abbott Park, IL American Chemical Society Washington, DC Bayer Corporation Pittsburg, PA Boehringer Ingelheim Ridgefield, CT BP Houston, TX Cargill Wayzata, MN Colgate-Palmolive Piscataway, NJ Corning Inc. Corning, NY Delaware State University Dover, DE Drug Enforcement Administration Arlington, VA 57

NOBCChE 2008 EXHIBITORS The Dow Chemical Company Midland, MI DuPont Pawtucket, RI Eastman Kodak Rochester, NY Eli Lilly and Company Indianapolis, IN Georgia Institute of Technology Atlanta, GA Howard University Washington, DC Hunter College Gene Center, Justgarciahill New York, NY Indiana University Bloomington, IN

The Johns Hopkins University Applied Physics Laboratory Laurel, MD Los Alamos National Laboratory Los Alamos, NM Lubrizol Wickliffe, OH 58

NOBCChE 2008 EXHIBITORS Massachusetts Institute of Technology Cambridge, MA Merck & Company, Inc. West Point, PA National Research Council of the National Academies Washington, DC National Institute of Standards Gaithersburg, MD NOAA Environmental Cooperative Science Center Tallahassee, FL Pfizer Groton, CT PPG Industries Pittsburg, PA Procter & Gamble Cincinnati, OH Rice University Houston, TX Roche Nutley, NJ Rohm and Haas Philadelphia, PA Savannah River National Laboratory Aiken, SC 59

NOBCChE 2008 EXHIBITORS The Broad Institute of MIT and Harvard Cambridge, MA United Negro College Fund Special Programs Corporation Fairfax, VA University of Kentucky Lexington, KY University of Delaware Dept of Chemical Engineering Newark, DE University of California – Davis Davis, CA University of Maryland College Park, MD University of Massachusetts Amherst Amherst, MA

60

FORUM AND WORKSHOP ABSTRACTS COACh Workshop I

7:00 AM – 5:00 PM Franklin 11 “The Chemistry of Leadership” Presented by Sandra Shullman

Sunday, AM/PM

This workshop is open to women academic faculty/administrators and industry/other. This program is designed to give participants some basic concepts and tools to develop their leadership skills. Participants will learn about various concepts of leadership (including their own), explore what is known about issues that pertain to minority women and its role in leadership situations, and reflect on their own leadership challenges whether it is in the classroom/office, working with committees or leading groups.

COACh Workshop II

7:00 AM – 5:00 PM Franklin 12 “Professional Skills Training for Minority Graduate Students and Postdocs” Presented by Jane Tucker and Ernestine Taylor

Sunday, AM/PM

This workshop is open to women Graduate students and Postdoctoral Associates. This workshop is designed to introduce negotiations or solution findings to graduate students and postdocs. Participants will learn to develop their “best alternative to a negotiated agreement” and finding their own personal negotiation styles. Attendees will practice through a selection from case studies including developing a strong advocate, credit for research and publications, developing connectedness, obtaining resources that enable productivity, opportunity to demonstrate strong performance, the “all important” reference letter and contracting for that first or new position. Discussions will focus on issues relevant to minority women.

Sunday AM/PM Monday AM/PM 8:00 AM – 5:00 PM

Agilent HPLC Data Analysis and Reporting – 2 Day Course (pre‐paid)

403

This two day course is designed for those who want to enhance their skills in the use of the Agilent HPLC (2D) ChemStation software. Laptop PCs using Agilent ChemStation software will be provided. A basic knowledge of the fundamentals of HPLC, Techniques of Modern HPLC (H1186A) or Practical High Performance Liquid Chromatography (H5930A) required. (Fee: $200 Class size limited to 15 participants)

61

FORUM AND WORKSHOP ABSTRACTS

Sunday AM/PM 8:00 AM – 5:00 PM

Seven Habits of Highly Effective People – 1 Day Course (pre‐paid)

411

This one day intensive course empowers people and organizations to significantly increase their performance capability as they work to achieve worthwhile purposes through understanding and living principle‐centered leadership. This course will focus on the basic personal and interpersonal skills from the world‐renowned 7 Habits. (Investment: $400 Class sizes limited to 20 participants)

Monday, AM

Preseenter:

Plenary I ‐ Bioapplications in Chemistry Symposium 9:00 AM ‐ 10:00 AM

Franklin 1

“Recent Progress in Computational Protein Design: Towards Designing Enzymes and Combinatorial Protein Libraries”

Dr. Stephen L. Mayo Vice Provost (research) and Bren Professor of Biology and Chemistry, California Institute of Technology, Pasadena, CA

Understanding the relationships between protein sequence, protein structure, and protein function remains is a central challenge in chemistry and biology. Combined computational and experimental approaches aimed at elucidating these relationships have led to a powerful method for the enhancement of naturally occurring proteins and the creation of new protein function. This presentation will cover the development of our computational protein design methodology and will focus on recent efforts to design enzyme‐like protein catalysts and combinatorial protein libraries. The computational protein design methodology that will be described in this presentation promises not only to revolutionize the conduct of biotechnology in the 21st century, but also to provide a tractable approach for studying the relationships between protein fold and the evolvability of protein function.

62

FORUM AND WORKSHOP ABSTRACTS

Monday, AM

Henry A. Hill Lecture 11:00 ‐ 11:50

Franklin 2 Sponsored by the American Chemistry Society Northeast Section

Dr. Henry A. Hill 1977 ACS President

Dr. Henry Aaron Hill (1915 – 1979), the renowned African ‐ American chemist in whose memory this award was established, was a former Chairman of the ACS Northeastern Section (1963) and President of the American Chemical Society in 1977. Dr. Hill’s outstanding contributions to chemistry, particularly industrial chemistry, and to the professional welfare of chemists are legion.

Dr. Hill’s first concern and interest was in his fellow humans, and this was the driving force behind all that he did both in the chemical community and the world at large.

Henry Hill was a native of St. Joseph, Missouri. He was a graduate of Johnson C. Smith University in North Carolina and received the doctorate degree from M.I.T. in 1942, after getting the highest grades in his class. He began a professional career in industrial chemistry in that year, with North Atlantic Research Corporation of Newtonville, Massachusetts. He eventually rose to be vice president while doing research on and development of water‐based paints, fire‐fighting foam, and several types of synthetic rubber. After leaving North Atlantic Research, he worked as a group leader in the research laboratories of Dewey and Almy Chemical Company before starting his own entrepreneurial venture—National Polychemicals in 1952. Ten years later he founded Riverside Research Laboratories in Cambridge, Mass. The firm offered research, development and consulting services in resins, rubbers, textiles and in polymer production. Riverside Research Laboratory introduced four successful commercial enterprises, including its own manufacturing affiliate. Dr. Hill, particularly after having been appointed by President Lyndon Johnson to the National Commission on Product Safety, became active in research and testing programs in the field of product flammability and product safety.

The American Chemical Society was always very close to Henry Hill’s heart. His active career with the ACS began in the middle 1950s in the Northeastern Section. Dr. Hill served on Northeastern Section committees, became a councilor in 1961 and was Chairman of the Section in 1963. He served the ACS in important National positions including secretary and chairman of the Professional Relations Committee, the ACS Council; Policy Committee, the Board of Directors, and ultimately president in 1977. He made an especially significant impact in professionalism by pioneering establishment of a set of guidelines defining acceptable behavior for employers in their professional relations with chemists and chemical engineers. This effort resulted in the ACS landmark document entitled ʺProfessional Employment Guidelines.ʺ Dr. Henry Hill remains to date as the only African American to become President of the American Chemical Society. In recognition of his many outstanding achievements, NOBCChE identifies an outstanding African – American chemist or chemical engineer to be designated as that year’s Henry A. Hill Lecturer. James E. West, Electrical Engineering Department, The Johns Hopkins Univerity 63

FORUM AND WORKSHOP ABSTRACTS (retired AT&T Bell Labs Distinguished Scientist), is this year’s honoree. Our award is sponsored by the ACS Northeast Section.

Monday, PM

Opening Luncheon

12:00 ‐ 1:50 PM Del Lago 3

“Nanosciences and Nanotechnology: Continuing Challenges and Opportunities for Chemists and Chemical Engineers” James W. Mitchell, Ph.D. David and Lucille Packard Professor, Chemical Engineering Department Howard University, Washington, DC

Scientists and engineers worldwide are vigorously creating new frontiers in research and developing innovative technologies to exploit the vast opportunities and potential of nanoscience and nanotechnology. This overview covers broadly the challenges, opportunities, and representative advances within selected interdisciplinary fields.

Extremely interesting and impacting possibilities exist, especially within the bionanomolecular sciences and nanomaterials device processing. The current status of advances in these areas at Howard University will be highlighted with specific examples.

Tuesday, AM/PM Wednesday, AM/PM

Teachers Workshop Salon IJ 7:00 AM – 5:00 PM

“Achieving Science Through Education”

Sponsored by 3M, AAAS, Abbott Laboratories, ACS, NASA/UCLA, and NOBCChE This year’s science teachers’ workshop will assist science educators at the elementary, secondary, and high school levels using various teaching strategies and techniques. The 2007 workshop will also provide resources and materials that will assist in enhancing your curriculum. In addition, educators will have an opportunity to discuss issues and various challenges that face science educators. The objective for this 2 day workshop is to assist educators in improving test scores among minority and underrepresented students. This will further assist students to pursue careers in science and technology.

A continental breakfast and lunch will be provided to registered teachers. There is no cost for science educators.

64

FORUM AND WORKSHOP ABSTRACTS Tuesday, AM

Presenter:

Plenary II ‐ Nanotechnology in Chemistry Symposium 8:30 AM ‐ 9:30 AM

“Non‐Spherical Particle Self‐Assembly For Light Control” Professor Chekesha M. Liddell Cornell University, Department of Materials Science and Engineering, Ithaca, NY 14853

Franklin 1

Controlling light‐matter interactions with materials structured at micron and submicron length scales has been predicted as the basis for enhancements in the performance of a range of technologies, including photovoltaics, sensors and high power, solid state lighting devices. The development of inexpensive processes to generate tunable structural complexity in functional materials is paramount to accessing new frontiers in light‐matter interactions for such applications. Because of its relative ease and potential for high volume manufacture at low cost, colloidal self‐assembly (particles in size regime ~100nm to ~1 micron) is an ideal fabrication process. However, the types of thermodynamically stable structures from simple building blocks, such as colloidal spheres, are very limited. For example, face‐centered cubic crystal structures have been a staple as templates for mesoporous materials although the light‐matter interaction in the structure is known to be relatively weak as compared to lower symmetry arrangements.

Non‐spherical colloidal particles dramatically expand the symmetry and topology that can be achieved using self‐assembly, allowing a much more extensive probe of the relations between unique photonic properties and mesoscale structure. The anisometric particle systems have notable analogy to molecular systems, where the shape of molecules and their packing density has been shown to critically influence structural phase behavior and lead to a rich diversity of structures, both natural and synthetic. However, experimental attempts to organize Fig. 1. Cartoon of systematic variation in particle shape for dimer colloidal building blocks. non‐spherical colloids have most often resulted in amorphous deposits or locally ordered films with small grain size. The challenges have been in attaining sufficiently monodisperse (size and shape uniformity) colloidal building blocks, as well as the lack of understanding and control of self‐ assembly processes for non‐spherical colloids. In this talk, the particle synthesis and the 65

FORUM AND WORKSHOP ABSTRACTS formation of complex colloidal structures from monodisperse dimer, spherocylinder, and peanut‐shaped building blocks using convective, confinement, and magnetic field‐ assisted assembly methods will be discussed.

PercyL Julian Luncheon Lecture 12:00 ‐ 1:30 PM

Tuesday, PM

Salon H

Dr. Percy L. Julian (1899 – 1975) National Academy of Sciences (Elected 1973)

The Percy L. Julian Award for significant contributions in pure and/or applied research in science or engineering is our most prestigious award. Dr. Julian was an African‐American who obtained his BS in Chemistry from DePauw University in 1920. Although he entered DePauw as a “substandard freshman,” he graduated as the class valedictorian with Phi Beta Kappa honors. His first job was as an instructor at Fisk University. Julian left Fisk and obtained a masterʹs degree in chemistry from Harvard in 1928, and his Ph.D. in 1931 from the University of Vienna, Austria. It was after his return to DePauw in 1933 that Julian conducted the research that led to the synthesis of physostigmine, a drug used in the treatment of glaucoma2. Julian left DePauw in 1936 to become director of research of the Soya Products Division of the Glidden Company in Chicago. This position at Glidden made Julian the world’s first African – American to lead a research group in a major corporation. Dr. Julian rewarded Gliden’s faith in him by producing many new commercial products from soy beans. An entrepreneur as well as a scientist, in 1953 he founded Julian Laboratories and later Julian Associates, Inc. and the Julian Research Institute. Over the course of his career he acquired over 115 patents, including one for a fire‐extinguishing foam that was used on oil and gasoline fires during World War II2. Though he had over 100 patents and 200 scientific publications, his most notable contribution was in the synthesis of steroids from soy and sweet potato products. Dr. Julian’s life and contributions were the subject of a recent biopic by NOVA/PBS entitled, “Forgotten Genius.”3 The film was broadcast nationally on February 6, 2007 on PBS TV stations.

The table below summarizes the winners of the NOBCChE Percy L Julian Award: Year

Award Recipients

Year Award Recipients

1975

Dr. Arnold Stancel (1) Mobil Oil Company

1994 Dr. Dotsevi Y. Sogah, Cornell University

1977 1979

Dr. W. Lincoln Hawkins, Bell Laboratories Dr. William Lester, Lawrence Berkeley Laboratory

1995 Dr. Joseph Francisco, Purdue University Dr. Edward Gay, Argonne National 1996 Laboratory

1981

Dr. James Mitchell (2), Bell Laboratories

1997 Dr. James H. Porter , UV Technologies 66

FORUM AND WORKSHOP ABSTRACTS 1982

Dr. K.M. Maloney, Allied Corporation

1983

Dr. B.W. Turnquest, ARCO Petroleum

1985 1986

Dr. William Jackson, (3) Howard University Dr. George Reed, Argonne National Laboratory

1987

Dr. Reginald Mitchell, Stanford University

1988 1989

Dr. Isiah Warner (4), Emory University Dr. James C. Letton, Proctor & Gamble Company Dr. Theodore Williams, College of Wooster (Ohio)

1990

Dr. William A. Guillory, Innovations 1998 Consulting Dr. Linneaus Dorman, Dow Chemical 1999 Company 2001 John E. Hodge (5) (1914–96), U.S. Department of Agriculture, Peoria, IL 2001 James A. Harris (5) (1932–2000), Lawrence Berkeley Laboratory 2002 Dr. Victor McCrary, Johns Hopkins Applied Physics Laboratory 2003 Dr. Victor Atiemo‐Obeng, Dow Chemical Company 2004 Dr. Gregory Robinson, University of Georgia 2005 Dr. James H. Wyche, University of Miami

1991

Dr. Bertrand Frazier‐Reed, Duke University

2006 Dr. Jimmie L. Williams, Corning Incorporated

1992

Dr. Willie May, NIST

2007 Dr. Kenneth Carter, UMass

1993 Dr. Joseph Gordon, IBM 2008 Dr. Sharon Haynie, DuPont Notes: (1) ‐ Currently at Georgia Tech; (2) Currently at Howard University; (3) Currently at UC Davis; (4) ‐ Currently at LSU; (5) – Awarded post humorously.

References and recommended reading 1 2 3

NOBCChE’s Percy L Julian Award, http://www.nobcche.org/index.cfm?PageID=50174597-757C-432EBA8C253625586175&PageObjectID=37 Percy Julian, Wikipedia Encyclopedia, http://en.wikipedia.org/wiki/Percy_Julian Julian – Trail Blazer, Peter Tyson, http://www.pbs.org/wgbh/nova/julian/civil.html

Tuesday, PM

PercyL Julian Luncheon Lecture 12:00 ‐ 1:30 PM

“Reflections from a Rover” Dr. Sharon Haynie, DuPont Company, Wilmington, DE

Salon H

Abstract Examples of advances in applied research using chemistry in biotechnology and biomaterials will be described. The lecture will also describe contributions and changes that broadened opportunities for women scientists. The talk is inspired from a footnote in Dr. Julian’s JACS paper describing the complete synthesis of physostigmine.

67

FORUM AND WORKSHOP ABSTRACTS

Tuesday, PM

Graduate Students Shoppers Delight: GEM

Informational Session and Graduate School Room 411 Survival Tips 1:45 P.M. – 3:30 P.M.

“How To Be Successful In Graduate School: Understanding Graduate School Lingo”

Presenters: Sibrina Collins*, University of Washington, Graduate School, Seattle, WA Marcus Huggans, The National GEM Consortium, Washington, DC

Earning a masters degree or a doctoral degree in the STEM (science, technology, engineering, and mathematics) fields is no easy task. Navigating through the graduate school landscape, learning the common graduate school language, and choosing the right research mentor are critical to graduate school success. In this session, we will discuss the masters degree verses the doctoral degree, your role within the research group, funding support, and completing your thesis or dissertation.

Tuesday, PM

Next Generation Process Automation at The Dow Chemical Company: The Room 413 Journey to Commercial Solutions 3:00 P.M. – 5:00 P.M.

Eric Cosman Engineering Solutions, The Dow Chemical Company

Process Automation has been a core competency in the operation of chemical manufacturing facilities for decades. The Dow Chemical Company has employed computer-based automation systems in our facilities since the mid 1960’s. Through five generations of a proprietary automation system we evolved a set of core principles and practices that are used in all of our automation projects. Since 2000 we have been working closely with ABB to make a transition from our proprietary systems to a commercially available alternative, while maintaining these core principles and practices. This is a collaborative effort across Dow’s Engineering, Manufacturing and Information Systems functions.

This presentation provides an overview of this transition, highlighting some of the challenges and lessons learned.

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FORUM AND WORKSHOP ABSTRACTS Tuesday, PM

Plenary III ‐ Health Symposium 4:00 PM ‐ 6:00 PM sponsored by Eli Lilly Company

Salon G

“AIDS/HIV in the African American Community: Addressing an Epidemic” Moderator: Presenters:

Dr. Ronald D. Lewis, II, Chair, 2008 NOBCChE Health Symposium Dr. Gail H. Cassell, Vice President, Scientific Affairs, Infectious Diseases, Eli Lilly and Company, Indianapolis, IN. Mr. Gary J. Bell, MSW, LCSW, BCD, (Private Practice) Plymouth Meeting, PA Dr. Carol Germaine, Biology Program Manager, R&D Informatics, Pfizer, La Jolla, CA. Dr. Pamela A. Clax, (Private Practice) Plymouth Meeting, PA Dr. Arlene Bardeguez, Professor of Obstetrics & Gynecology, University of Medicine and Dentistry of New Jersey, Newark, NJ.

Since the beginning of the AIDS/HIV epidemic, blacks have accounted for 397,548 (42%) of the estimated 952,629 AIDS cases diagnosed in the 50 states and the District of Columbia.

According to the 2000 census, blacks make up approximately 13% of the US population.

However, in 2005, blacks accounted for 18,121 (49%) of the estimated 37,331 new HIV/AIDS diagnoses in the United States in the 33 states with long‐term, confidential name‐based HIV reporting. Surprisingly, the rate of AIDS diagnoses for black adults and adolescents was 10 times the rate for whites and nearly 3 times the rate for Hispanics. The rate of AIDS diagnoses for black women was nearly 23 times the rate for white women. The rate of AIDS diagnoses for black men was 8 times the rate for white men. As a result, blacks account for 20,187 (50%) of the estimated 40,608 AIDS cases diagnosed in the 50 states and the District of Columbia. Of persons whose diagnosis of AIDS had been made during 1997–2004, a smaller proportion of blacks (66%) were alive after 9 years compared with American Indians and Alaska Natives (67%), Hispanics (74%), whites (75%), and Asians and Pacific Islanders (81%) [1,2]. Our expert panel will shed light on these facts, the many causal factors of AIDS/HIV, the stigmas attached to the disease, issues facing the African American community, as well as the science behind some of the leading marketed antiviral drugs.

References: 1. http://www.cdc.gov/hiv/topics/aa/resources/factsheets/aa.htm and references therein.

2. http://www.blackaids.org and references therein.

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FORUM AND WORKSHOP ABSTRACTS

Our Chemistory: Celebrating Our History in Wednesday, AM Franklin 1 the Chemical Sciences 10:00 AM ‐ 11:00 AM

Dr. Sibrina N. Collins, Graduate School, Univewrsity of Washington, Seattle, WA 98115 Presenters: Dr. Marquita M. Qualls, 2GlaxoSmithKline, King of Prussia, PA 19406 Dr. Anthony Dent, PQ Corporation (Retired), Conshohocken, PA 19428

We have a remarkable legacy in the chemical sciences for us to cherish and to emulate. The achievements of pioneers such as Dr. Saint Elmo Brady, Dr. Marie Maynard Daly, Dr. Jennie Patrick, Dr. Percy L. Julian and the seven NOBCChE founders—Dr. Joseph Cannon, Dr. Lloyd Ferguson, Dr. William Jackson, Dr. William Guillory, Dr. Henry McBay, Dr. Charles Merideth, and Dr. James Porter—created high standards of excellence for generations of African American chemists and chemical engineers to follow. A few career highlights include:

• Dr. Saint Elmo Brady helped establish a summer program for faculty focusing on infrared spectroscopy at Fisk University.

• Dr. Jennie Patrick initiated and developed a research engineering program focusing on supercritical fluid extraction technology.

• Dr. William Jackson was the first scientist to use a tunable laser to study free radicals from photo‐dissociation and the first determination of the radiative lifetimes of individual rotational levels of a free radical and demonstrated how two electronic states perturb each other.

• Dr. Marie Maynard Daly received a grant from the American Cancer Society and worked as a postdoctoral researcher at the Rockefeller Institute focusing on nucleic acids and other biological systems.

• In 1933, Dr. Percy Julian conducted the research that led to the synthesis of physostigmine, a drug used in the treatment of glaucoma. In 1949, he synthesizes Compound S, a major ingredient in low‐cost cortisone. Dr. Percy Julian established the Julian Laboratories in 1953 with the primary goal of producing steroids; Julian Laboratories was sold for $2 million dollars in 1961.

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FORUM AND WORKSHOP ABSTRACTS Moreover, through the help of several corporate sponsors, NOBCChE has provided scholarships and fellowships to many talented young African Americans in order to achieve their full potential in the chemical sciences. In this session, we will discuss the history and impact of NOBCChE and the contributions of African American pioneers in the chemical sciences.

Wednesday, AM

Presenter

Plenary IV – Jumpstarting Your Career Breakfast Served 7:30 AM ‐ 9:00 AM Sponsored by Rohm and Haas Company

Salon H

“Finding Your Passion!”

Cathie Markham, Vice President of Technology and Chief Technology Officer Rohm and Haas Company

Do you ever wonder whether you are on the right track? If you have really found your passion? Cathie will share personal career perspectives and anecdotes about finding or creating a positive match between your job, your abilities and what is meaningful to you in this inspirational message about Finding Your Own Passion.

Wednesday, AM

You Donʹt Know What You Donʹt Know: Emotional Intelligence Room 411 8:00 AM ‐ 5:00 PM

Presenter

David G. Lewis, Lewis Consulting Group

EQ is the ability to integrate thinking and feeling to make optimal decisions. It is the capacity to effectively manage our own emotions and recognize those of others. Participants will take an Emotional Intelligence Test to determine their Emotional Intelligence Quotient (EQ).

Investment: $ 500 Class size limited to 20 participants

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FORUM AND WORKSHOP ABSTRACTS

ACS ‐ Leading Change Wednesday, PM

(Pre‐registration required) 2:00 PM ‐ 5:00 PM

Room 412

Almost any initiative today in the workplace or within a NOBCChE committee or project team involves change. It could be a change in priorities and direction, people, or goals and objectives. And, with change often comes resistance. How many times have you been on the receiving end of: • • •

People pushing back because the committee is given a different set of goals to achieve?

Projects stalling because there has been a change in the direction?

Confusion due to personnel changes on a committee or project team?

This four‐hour course provides leaders with a step‐wise process to lead change and guide volunteers more effectively through the change process for greater results and efficiency.

Those who are leading projects such as change initiatives, projects requiring working with other groups, or new initiatives that will likely experience changes in the course of completion, are encouraged to attend this program.

Participants will gain a skill that can be used daily in both volunteer leadership roles as well as in your profession. Specifically, you will learn: • • • • •

Why organizations and individuals tend to resist change.

A 3‐step process for leading change amongst volunteers in a team or work group.

How to maintain a clear vision of the strategic direction and instill a strong sense of direction and purpose in all volunteers.

How to keep everyone on‐track and focused on top priorities.

The importance of and how best to communicate new insights into key issues, problems and opportunities the committee faces.

Investment: Free, but registration still required Class size limited to 25 participants

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FORUM AND WORKSHOP ABSTRACTS Wednesday, PM

Presenter

NSF and DOD Fellowship Informational Session 2:00 PM 3:30 PM

Room 415

Mr. Tim Turner, ASEE Program Director, NSF Graduate Research Fellowships.

Workshop Content The workshop will provide students with insights into several fellowship/scholarships programs available to help them fund their studies. A detailed presentation will be given about the National Science Foundation’s Graduate Research Fellowship Program, the Department of Defense National Defense’s Science and Engineering Graduate Fellowship Program (NDSEG), and the Science, Mathematics and Research for Transformation (SMART) Scholarship Program. The presentation will describe these fellowships’ eligibility requirements, application processes and components, and also provide suggestions for submitting a competitive application.

Summary Description of each Program The National Science Foundation’s Graduate Research Fellowship Program. This fellowship program provides students with three years of financial support including a $30,000 annual stipend and $10,500 cost‐of‐education allowance. U.S. citizens, nationals, or permanent resident aliens at or near the beginning of research‐based graduate studies in the Chemistry, Computer and Information Science and Engineering, Engineering, Geosciences, Life Sciences, Mathematical Sciences, Physics and Astronomy, Psychology, and Social Sciences fields are eligible to apply. For additional program information, please visit: https://www.fastlane.nsf.gov/grfp/.

The National Defense Science And Engineering Graduate Fellowship Program (Ndseg). This fellowship program is sponsored by the Army Research Office, Office of Naval Research, Air Force Office of Scientific Research and the Department of Defense Performance Computing Modernization Program This program is intended for U.S. citizens at or near the beginning of their graduate studies in science and/or engineering programs. The fellowships are for three year tenures. The stipends begin at $30,500 for first year fellows, $31,000 for second year fellows, and $31,500 for third year fellows. Full tuition and fees and a health insurance allowance are included as part of the program.

Please visit: http://www.asee.org/ndseg for application deadlines and detailed program information.

Science, Mathematics And Research For Transformation (Smart) Education Program. This education program provides scholarships and fellowships to students including an annual salary, full tuition, and other normal educational expenses. The purpose is to promote the education, recruitment and retention of undergraduate and graduate students in science, mathematics and engineering studies. The SMART Education Program is open only to citizens of the United States, and students must be at least 18 years of age to be eligible. There is an employment obligation to Department of Defense with this education program. For more information and application deadlines, please visit http://www.asee.org/smart.

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FORUM AND WORKSHOP ABSTRACTS

Financial Accounting Management Services

Financial Accounting Management Services, LLC 4525 Flat Shoals Parkway Ste 403 Decatur, Georgia 30035 404/212-9846 Fax 404/212-9847

Certified Public Accountants

Our firm has over thirty-seven years of combined auditing and accounting experience. Our clients included local and state governments, nonprofit organizations, schools, churches, constructions, physicians and others.

Internal Controls, how effective are your internal controls?

Our team of professional will perform a review of your firm’s internal controls and process flows. We will assess the control environment, document business process, and assess internal controls and financial risk.

Other Accounting and Financial Management Services • Placement of temporary accountants, auditors, seniors auditors and accounting managers.

• Financial, performance and compliance reviews and audits.

• Documentation and evaluation of business process flows.

• Business Consultant • Tax planning and preparation.

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CONFERENCE SPEAKERS COACh Workshop I

7:00 AM – 5:00 PM Franklin 11 “The Chemistry of Leadership” Presented by Sandra Shullman

Sunday, AM/PM

SANDRA L. SHULLMAN, Ph.D. S

Dr. Shullman is Managing Partner, Columbus Office of the Executive Development Group, an international leadership development and consulting firm. She received her Ph.D. in counseling psychology from The Ohio State University. During that same time, Sandy was a co‐founder of the Women’s Studies Program at Ohio State.

Dr. Shullman is a nationally known organizational consultant and has written and presented extensively on the topics of performance appraisal, performance management, strategic succession planning, career development, management of self‐esteem and motivation, team building, diversity management, and the management of individual, organizational and systems change strategies. She is well known for her work related to executive assessment and development and co‐authored Performance Appraisal on the Line.

COACh Workshop II

7:00 AM – 5:00 PM Franklin 12 “Professional Skills Training for Minority Graduate Students and Postdocs” Presented by Jane Tucker and Ernestine Taylor

Sunday, AM/PM

JANE W. TUCKER, Ph.D.

Jane Tucker has over twenty‐five years of experience in higher education in both the administrative and teaching areas. She has taught negotiation skills in the Fuqua School of Business at Duke and is currently a consultant educator for COACh through the National Science Foundation. She has also taught ADVANCE program seminars in negotiations and is adjunct faculty for the Center for Creative Leadership, where she works with leaders from both non‐profit organizations and corporations.

Dr. Tucker holds a Ph.D. in Organizational Development from the University of North Carolina and is an alumna of Wellesley College. She has published papers on learning strategies and organizational development. Her current research interest is focused on early adopters in change processes.

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CONFERENCE SPEAKERS Ernestine T. Taylor

Ernestine T. Taylor worked more than 20 years at the executive level in human resources and organizational development with fortune 500 companies such as Ortho‐McNeil Pharmaceutical (Johnson & Johnson), Avon Products Company, Inc. Continental Can and Ford Foundation. She has taught management and business communications courses at Elon University, Bennett College for Women and several community colleges in New Jersey, New York and Connecticut.

In 2002, Taylor established ETConsulting with a focus on executive coaching, leadership development and team building As an independent consultant, she is a facilitator and executive coach for healthcare organizations, aerospace, energy, telecommunications, educational institutions and governmental agencies.

Featured in Ebony Magazine(1990), as one of Best and Brightest Black Women in Corporate America.

Plenary I ‐ Bioapplications in Chemistry Symposium 9:00 AM ‐ 10:00 AM

Monday, AM

Franklin 1

Dr. Stephen L. Mayo Vice Provost (research) and Bren Professor of Biology and Chemistry California Institute of Technology Pasadena, CA

Dr. Stephen L. Mayo is currently Vice Provost (research) and Bren Professor of Biology and

Chemistry at Caltech in Pasadena, CA, where he runs a lab of approximately fifteen graduate students, postdocs, and staff.

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CONFERENCE SPEAKERS Dr. Mayo is a pioneer and leading figure in the field of protein design. His work at the interface of theory, computation, and experiment is aimed at understanding the physical/chemical determinants of protein structure, stability, and function. Dr. Mayo and his coworkers were the first to show that a quantitative description of protein thermodynamics could be coupled with combinatorial search techniques capable of addressing the enormous combinatorial space available to protein sequences. In their 1997 Science article, Dr. Mayo and his coworkers demonstrated the validity of their theoretical and computational approach by experimentally validating that a designed protein sequence actually folded to its intended 3‐dimensional structure. This and related work have been viewed as the harbinger to a complete solution to the inverse protein‐folding problem (that is, the problem of predicting amino acid sequences that will fold to specific protein structures). A solution to this problem will have a profound impact on our ability to understand the evolution of protein sequences, structures, and functions, as well as on prospects for continued development of protein‐based biotechnologies.

Dr. Mayo has received a number of honors including being named a Howard Hughes Medical Institute Investigator, a Rita Allen Foundation Scholar, a David and Lucile Packard Foundation Fellow, and a Searle Scholar. In 1997 he was recognized for his pioneering work in protein design by being awarded the Johnson Foundation Prize for Innovative Research in Structural Biology. In 2004 he was elected to the National Academy of Sciences.

Dr. Mayo is a native of Texas, but grew up primarily in Pennsylvania and New Jersey as part of a “military” family. He earned his B.S. in Chemistry at the Pennsylvania State University, and received a Ph.D. in Chemistry from Caltech in 1987. Dr. Mayo did postdoctoral work as a Miller Fellow in the Chemistry Department at UC Berkeley. After working for two years at a software company he cofounded (Molecular Simulations, Inc.), he did additional postdoctoral work in the Biochemistry Department at Stanford University School of Medicine before returning to Caltech as an Assistant Professor of Biology in 1992. Dr. Mayo also cofounded Xencor in 1997 and served as the Chair of its Scientific Advisory Board until 2006.

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CONFERENCE SPEAKERS Henry Hill Lecture 11:00 ‐ 12:00 AM

James E. West Professor of Electrical Engineering The Johns Hopkins University

Monday, AM

Franklin 2

Sponsored by the American Chemistry Society Northeast Section and the MIT Chemistry Department

In a White House Ceremony on July 27, 2007, President George W. Bush presented the 2006 National Medal of Technology to James E. West, for co‐inventing the electret microphone in 1962. Ninety percent of the two billion microphones produced annually and used in everyday items such as telephones, hearing aids, camcorders, and multimedia computers employ electret technology. The National Medal of Technology is the nation’s highest honor awarded by the USA President to America’s leading inventors and technological innovators. “The National Medal of Technology recognizes American innovators who have made lasting contributions to advancing our global competitiveness, economic prosperity and quality of life.

James West and Dr. Gerhard M. Sessler at Bell Laboratories (Murray Hill, New Jersey) in the 1960s invented the foil electret microphone in response to the challenge to develop a more affordable and accurate microphone. In the process of achieving this goal, Jim became a world renowned expert in acoustics ‐ electroacoustics, physical and architectural acoustics. West holds 47 U.S. and more than 200 foreign patents on various microphones and techniques for making polymer electrets. He was inducted into The National Inventors Hall of Fame in 1999 for the invention of the electret microphone. He has authored more than 100 papers and has contributed to several books on acoustics, solid state physics, and material science. West is a member of the National Academy of Engineering; a Fellow, and past President, and past member of The Executive Council of Acoustical Society of America (1998‐2001), and a Fellow of the IEEE. He is a member of the Board of Directors of The National Inventors Hall of Fame, a member of the National Academy of Engineering’s Committee on Diversity in the Engineering Workforce and a member of the Scientific Advisory Committee of The International Symposium on Electrets.

His numerous distinctions include Fellowship in the IEEE and membership in the National Academy of Engineering, National Patent Law Association, the Electrochemical Society of 78

CONFERENCE SPEAKERS America, the Acoustical Society of America and the National Society of Black Engineers. In 1997, he was named president‐elect of the Acoustical Society of America (ASA). West is the recipient of the Callinan Award (1970), sponsored by the Electrochemical Society of America, the Senior Award (1970), sponsored by the IEEE Group on Acoustics, the Lewis Howard Latimer Light Switch and Socket Award (1989), sponsored by the National Patent Law Association, the George R. Stibitz Trophy, sponsored by the Third Annual AT&T Patent Award (1993), and the New Jersey Inventor of the Year for 1995. He received The Acoustical Society of Americaʹs Silver Medal in Engineering Acoustics (1995), an honorary Doctor of Science degree from New Jersey Institute of Technology (1997). He received the Golden Torch Award (1998) sponsored by the National Society of Black Engineers, the Industrial Research Institutes 1998 Achievement Award, and The Ronald H. Brown American Innovator Award (1999). In 2002 he was The Audio Engineering Society Richard C. Heyser Memorial Lecturer. West was awarded the Lewis Howard Latimer 2003 achievement award, and the John William Strutt, 3rd Baron of Rayleigh 2003 Award, presented by the Mexican Institute of Acoustics. One of his early publications has been chosen as a ``Benchmarkʹʹ publication by the Acoustical Society of America.

In 2001, Jim West retired as a Distinguished Member of Technical Staff and Bell Laboratories Fellow, Lucent Technologies. Since 2002, he has served as a research professor in the Whiting School of Engineering of The Johns Hopkins University in Baltimore. Since joining the Whiting School faculty, West has continued to experiment with new communications materials and technologies and has conducted research aimed at reducing hospital noise.[3] Does the noise level in a hospital affect healing or recovery rates?

Jim West has been a long time supporter of NOBCChE and NSBE in their efforts to increase the number of minorities and women to enter the fields of science, technology and engineering. He was instrumental in convincing AT&T Bell Labs and its affiliates to support the Corporate Research Fellowship Program, which funds graduate students seeking terminal degrees in scientific fields. The program has existed for 30 years, West says, and more than 500 PhDs have been awarded to women and minorities in those disciplines. He has continued to be active in such programs at Johns Hopkins. He was named Chairman of the Divisional Diversity Council of the Whiting School in the fall of 2002.

James E. West was born on February 10, 1931 in Farmville, Virginia. His first college experience was at Hampton University as a pre‐med major. This was in keeping with his father’s advice that there were no opportunities for Blacks in the science fields during the 50s. However, following his true passion, he attended Temple University, completing his B.S. degree in physics in 1957, and began working for the Acoustics Research Department at AT&T Bell Labs, where he had participated in internships as a college student. The rest, we know is history. Whenever you talk on the telephone, you’re probably using his invention.

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CONFERENCE SPEAKERS Monday, PM

Opening Luncheon 12:00 – 1:30

Salon H

Dr. James W. Mitchell David and Lucille Packard Professor Chemical Engineering Department Howard University Washington, DC 20059

Dr James (Jim) Mitchell, a National Academy of Engineering Member and Bell Labs Research Fellow, retired as Vice President of Materials Research at Lucent Bell Labs, Murray hill, NJ in 2001. Mitchell is recognized for developing high reliability quantitative characterization methods which laid the foundation for the analytical chemistry of optical waveguide technology. Mitchell’s second career involves academia, where he is the David and Lucille Packard Professor of Materials Science at Howard University .He is the Director of the CREST Nanomaterials Characterization Science Center, where his group develops methods for the synthesis and characterization of ultra pure biocompatible nanomaterials for research and technological applications.

Monday, PM

Technical Session 3 1:45 PM – 2:15 PM Dr. Henry McBay Outstanding Teacher Awardee

Room 410

Alvin P. Kennedy Department of Chemistry, Morgan State University

Dr. Alvin P. Kennedy received his undergraduate education at Grambling State University. While at Grambling he had a very rich undergraduate research experience. He was a participant in cooperative and summer internships at Brookhaven National Labs, Dow Chemical Company, Dowell and At&T Bell Laboratories. He received his bachelorʹs degree in 1978 and was awarded an AT&T Bell Laboratories Cooperative Research Fellowship. He matriculated to the University of California at Berkeley where he did his graduate work with Professor George C. Pimentel. He received his PhD in Physical Chemistry in 1985.

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CONFERENCE SPEAKERS Upon completion of his PhD, Dr. Kennedy joined Dow Chemical and became a Project Leader in the Advanced Electronics Materials Division in Central Research. He received several patents for his work in dielectric polymers and was awarded “Outstanding Paper” at the 7th Annual International Microelectronics Conference. While at Dow, he began to mentor high school and college students and had the privilege of one of his students being a finalist in the Westinghouse Competition.

In 1991 Dr. Kennedy joined the Chemistry Department at North Carolina A&T as an Assistant Professor. His research focused on the development of in‐situ dielectric monitoring of polymerization reactions and processes in microgravity, and he was awarded a NASA/ASEE Research Fellowship to conduct research at Marshal Space Flight Center. He also served as Program Coordinator and mentor for the NASA Sharp Plus High School program for several years. He once again experienced the privilege of one of his students receiving 1st place in the International Space Olympics in Moscow, Russia.

In 2000 Dr. Kennedy became Professor and Chair of the Department of Chemistry at Morgan State University. He immediately began to build the research infrastructure necessary for creating a program that would serve as the foundation for developing a Continuous Undergraduate Research Experience (CURE). He has been very successful in receiving internal and external funding to develop the infrastructure needed for teaching and research. Dr. Kennedy has established a research collaboration at Morgan whose focus is the development of Sensors for BioEnvironmental Research (SenBER). He is PI of two grants which support this research, NSF Research Infrastructure for Science and Engineering (RISE) and DOE Biosensors for Environmental Toxicology (BET).

Dr. Kennedy is currently serving as Director of Morganʹs NSF HBCU‐UP Undergraduate Research Development Program. Despite his numerous administrative duties, Dr. Kennedy is still very active in his true passion as a researcher and mentor. He has served as research mentor for over 50 graduate, undergraduate and high school students in a variety of programs including ACS‐SEED, NASA SHARP‐PLUS, NIH MARC, NIH MBRS, NSF LSAMP, NSF HBCU‐UP, NSF RISE and the Ronald McNair Post‐Baccalaureate Program.

During his tenure at Morgan, his students have won numerous awards at various meetings including NOBCChE. This includes the highly memorable NOBCChE 2004 meeting when Morgan students swept the NOBCChE undergraduate research awards, winning the NOBCChE Poster and the Rohm & Haas Undergraduate competitions.

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CONFERENCE SPEAKERS

Tuesday, AM Wednesday, AM

Teachers Workshop 7:00 AM ‐ 5:00 PM

Salon IJ

“Achieving Science Through Education” Sponsored by 3M AAAS, Roche Pharmaceuticals, and Committee for Action Program Services

Mrs. Linda Davis, Committee Action Program Services Linda L. Davis is founder and executive director of the Committee for Action Program Services (CAPS). CAPS is a non‐profit organization specializing in teacher’s professional development in science and technology. In addition, she provides science enrichment program for students in grades 4 through 12, such as field trips to Johnson Space Center ‐ Houston; facilitate overnight camps to Science Place, Fair Park in Dallas, Texas.

CAPS has collaborated with the Luna Planetary and Institute (LPI) and the Genesis Mission Program, a space science educational program through NASA on professional development workshops for science educators in Dallas, Texas Mrs. Davis is the Administrator at Inspired Vision Academy I in Dallas, Texas. Her responsibilities include special program coordinator for science curriculum and enrichment programs; elementary advisor for test required programs; grant writer for the science department and community outreach programs, and coordinator/facilitator for staff development. Mrs. Davis holds a Bachelor of Science in Organizational Management from Paul Quinn College in Dallas, Texas.

DR. SAUNDRA YANCY McGUIRE Dr. Saundra Yancy McGuire is the Director of the Center for Academic Success, Adjunct Professor of Chemistry, and Associate Dean of University College at Louisiana State University in Baton Rouge, Louisiana. She received her B.S. degree, magna cum laude, from Southern University, Baton Rouge, LA; her M.A. from Cornell University, Ithaca, NY; and her Ph.D. in Chemical Education from the University of Tennessee at Knoxville, where she received the Chancellor’s Citation for Exceptional Professional Promise. Prior to joining LSU in August 1999, she spent eleven years at Cornell University, where she served as Director of the Center for Learning and Teaching and Senior Lecturer in the Department of Chemistry, and received the coveted Clark Distinguished Teaching Award. Dr. McGuire is the author of numerous publications, including the Problem Solving Guide and Workbook, Study Guide, and Instructorʹs Teaching Guide for Russo/Silverʹs Introductory Chemistry, Third Edition. She is the recipient of numerous awards. Her most awards include the 2007 Diversity Award from the Council on Chemical Research; the 2006 Presidential Award for Excellence in Science, Mathematics, and Engineering Mentoring, awarded by President Bush in an Oval Office Ceremony; the 82

CONFERENCE SPEAKERS 2005 National Service Award and the 2002 Dr. Henry C. McBay Outstanding Chemistry Teacher Award, both presented by the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE); and the 2003, 2004, 2005, and 2007 Teaching in Higher Education Conference Outstanding Presentation Award. Additionally, she was designated a 2003 YWCA Woman of Achievement in the City of Baton Rouge, Louisiana. She is married to Dr. Stephen C. McGuire, and they are the parents of Dr. Carla Abena McGuire Davis and Dr. Stephanie Niyonu McGuire, and the grandparents of Joshua Bolurin, Ruth Anaya, Daniel Tabansi, and Joseph Olufemi Davis.

Ms. Jennifer Stimpson, Educator, Innovator and Scientist, Yvonne A. Ewell Townview Center Ms. Stimpson is a 10th grade chemistry teacher at the Y.A. Ewell Townview Magnet Center in the Dallas, TX metroplex. Her campus was rated the 2006 #1 High School in the Nation by US News and World Report. A native of Dallas, Texas, Jennifer matriculated through Dillard University where she received her Bachelor’s of Science in Chemistry and the University of Northern Iowa where she received her Master’s degree in Environmental Chemistry. Ms. Stimpson has taught at the collegiate level as well as at the elementary level. Jennifer brings a unique, fun and festive approach to learning chemistry.

In 2004, Jennifer developed a non‐profit Organization with the goal to advance the knowledge of education thorough innovation and science. . . KIC, which stands for Knowledge In Chemistry, is a specialized science program designed to enhance competency in chemistry, is the major launch under the non‐profit. This award winning program has been implemented in conjunction with Delta Sigma Theta Sorority, The Women’s Museum and the University of Texas at Dallas.

The two things that Jen is most passionate about are world‐travel and science education.

This world traveler spent the summer of 2007 in Ghana spreading the importance of a global science education. Jennifer’s motto is that youths should get a “KIC” out of science through “Knowledge In Chemistry!”

Mr. Michael L. Osborne, Market Strategy Manager, Texas Instruments, Education Technology Michael L. Osborne is a Market Segment Strategy Manager for Science with Texas Instruments. His role at TI is to provide support to middle and high school science teachers that use TI products in their classroom and to increase the level of awareness of TI products within the science education community. Michael has been with TI since February 9, 2002.

Prior to joining TI, he worked as a district level science specialist with Memphis City Schools for 7 years and taught high school chemistry in the district for 18 years. Over the 83

CONFERENCE SPEAKERS years, he has been active in a number Science teacher organizations having served as the President‐elect for the Tennessee Science Teachers Association, President of the Memphis Organization of Science Teachers, and Vice –President of the Memphis Area High School Chemistry Teachers Association.

JAMES GRAINGER, PhD, Analytical/Environmental Chemist, Center for Disease Control and Preventive Dr James Grainger is an analytical/environmental chemist at the Centers for Disease Control and Prevention in Atlanta, currently responsible for the PAH Adducts Group in the National Center for Environmental Health. Primary projects include development of new analytical methods for extending analytical exposure windows for organic environmental toxicants through human exposure profiles of DNA, serum albumin and hemoglobin adducts. Born in South Carolina, he received a BS in chemistry from South Carolina State College, a MS degree in physical/organic chemistry from Atlanta University, and a PhD in polymer/organic chemistry from Atlanta University. Dr Grainger has developed and presented a variety of talks on African origins of mathematics, science and technology, developing a multidisciplinary course on a chemistry platform entitled Prehistoric Future Chemistry I. The course examines the development of art, mathematics, science and technology in five river civilizations from the Stone Age to the Iron Age and was taught for two years at Spelman College. Dr Grainger currently serves as NOBCChE Southeast Regional Chair. Central to his variety of interests are family interactions with wife, Barbara, daughter Adrienne, son Daren and grandchildren AJ and Ari.

Ms. Yolanda George, American Association for the Advancement of Science Yolanda S. George is Deputy Director and Program Director for the Directorate for Education and Human Resources Programs (EHR) at the American Association for the Advancement of Science (AAAS). Her responsibilities include conceptualizing, developing, implementing, planning, and directing multi‐year intervention and research projects related to increasing the participation of minorities, women, and disabled persons in science and engineering. Her recent K‐12 mathematics and science reform work includes contributing to the development of materials for infusing equity into systemic reforms and conducting research on how state departments of education and school districts are aligning equity and science and math initiatives. Also, she has conducted equity reviews for textbooks and software publishers and test developers, including New Standards Science. She serves as a consultant to numerous federal and state agencies, foundations and corporations, and colleges and universities including the National Science Foundation, the U.S. Department of Education, Carnegie Corporation of New York, the New Jersey State Department of Education, and the Louisiana State Department of Education, and serves on several advisory boards including the National Academy of Engineering Committee on Women in Engineering, California State University, Los Angeles Access Project, and WGBH Instructional Television Science Project and others.

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CONFERENCE SPEAKERS

Plenary II ‐ Nanotechnology in Chemistry Symposium 8:30 AM ‐ 9:30 AM

Tuesday, AM

Franklin 1

Dr. Chekesha Liddell Chemical Engineering Department Cornell University Ithica, NY

Chekesha Liddell received a Bachelor of Science in Chemistry with Highest Distinction from Spelman College (1999) and a Bachelor of Materials Engineering from Georgia Institute of Technology (1999), [Atlanta University Center, Dual Degree Engineering Program]. She was awarded the NASA Women in Science and Engineering Scholarship to support her undergraduate work including an honors thesis on the Synthesis and Characterization of m‐Aminobenzenarsonic acid, an important standard for understanding the metabolysis of arsenic in poultry. Liddell also held three internship appointments at NASA, Kennedy Space Center in the Cryogenics and External Tank Branch and the Microchemical Analysis Laboratories. She joined the Cornell University faculty in November of 2003, after receiving a Ph.D. in Materials Science and Engineering with a minor in Science and Technology Policy from Georgia Tech.

Dr. Liddellʹs awards for scholarly achievement include the National Science Foundation (NSF) Presidential Early Career Award (PECASE, 2007) as well as the CAREER Award [Nonspherical, Active, and ʺInvertedʺ Bases for Optimized Photonic Crystal Design] (2006); Facilitating Academic Careers in Engineering and Sciences Career Initiation Grant, (2003); Office of Naval Research Graduate Fellowship (1999‐2003); Georgia Tech President’s Fellowship, (1999‐2003); Facilitating Academic Careers in Engineering and Sciences Fellowship (1999‐2003); NSBE, National Society of Black Engineers Fellow, 2000); Hertz Foundation Fellowship Grant, (1999); TMS materials society, J. Keith Brimacombe Presidential Scholarship, (1999); ASM Foundation Scholarship, ASM International materials society, (1998); and the ASTM, American Society for Testing and Materials, Mary R. Norton Memorial Fellowship, (1999). Liddell is a member of Phi Beta Kappa, the American Chemical Society, the Materials Research Society, the Cornell Center for Materials Research (CCMR) and the Cornell Center for Nanoscale Systems (CNS).

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The Liddell group research efforts focus on the development of colloid‐based materials [using synthetic chemistry, surface modification, self‐assembly and field‐directed assembly] and on understanding the relationship between their structure and optical properties.

Tuesday, PM

Percy L. Julian Luncheon 12:00 – 1:15 PM

Salon H

Dr. Sharon L. Haynie Research Scientist, DuPont Company Wilmington, DE

Sharon L. Haynie was born and raised in Baltimore, Maryland and educated in the Baltimore City Public Schools where she had her first chemistry course in 8th grade because her science class was selected to participate in a national pilot study on the effectiveness of teaching chemistry in junior high school. At the University of Pennsylvania she enjoyed research experiences ranging from organic synthesis, biophysics and biochemistry to biochemical engineering. This broad exposure to and enjoyment of the chemical sciences led her to the Massachusetts Institute of Technology (1977 – 1981, Ph.D., Chemistry) where she studied in an atmosphere of broad, diverse science with Professor George Whitesides.

Sharon enjoyed a 3‐year stint at the former AT&T Bell Laboratories before she joined the research community of the DuPont Company at the Experimental Station Laboratories (Wilmington, Delaware). For most of her 24‐year tenure, she has been in the Central Research & Development Department. Her research activities have ranged from new materials for therapeutic use (e.g. vascular graft; antimicrobial materials, medical adhesives) to biocatalysis for green chemistry applications. She was a member of a large DuPont/Genencor team that received the 2003 EPA Presidential Green Chemistry Award for New Innovation in developing a commercial bio‐process to 1,3‐propanediol. Sharon has also served brief tenures as adjunct professor of chemistry at Delaware State University and the University of Delaware.

Throughout her career, Sharon has been active in various professional service communities. She is currently serving terms in American Chemical Society (ACS) governance and the Chemical Sciences Roundtable of the National Academy of Sciences.

She has served as a past‐chair of the Philadelphia Section, ACS, co‐chair of the 2007 ACS 86

CONFERENCE SPEAKERS Middle Atlantic Regional Meeting. For ten years, Sharon served as a research mentor for a high school intern through ACS Project SEED.

Beyond science service, Sharon enjoys volunteer work that strengthens individuals and improves the urban community where she lives. These activities have been diverse and have ranged from service on community policing advisory boards, science textbook reader for Recording for the Blind & Dyslexic to tutoring adults with basic literacy needs.

She has a passion for reading, basketball, jazz, visual and vocal arts, walking and traveling.

Dr. Kenneth Carter is an Associate Professor in the Polymer Science and Engineering Department at the University of Massachusetts – Amherst. He joined the UMass faculty in 2004 after close to 20 years experience in polymer research including 13 years at IBM’s Almaden Research Center in San Jose, CA. In 1985, he earned his B.S. in Chemistry from the State University of New York at Oneonta. He received his Ph.D. in Inorganic Chemistry from the University of Vermont in 1991, and he went to the IBM Research Division upon graduation.

Dr. Carter’s research interests involve the synthesis and characterization of novel polymeric materials with specially designed properties. Carter’s research has focused on the development of organic and hybrid materials for future use in advanced electronics and storage technologies. These have included polymer dielectrics, electronic packaging materials, specialty printer toners, organic display materials, advanced magnetic media and pattering of nanostructured materials for advanced applications. Dr. Carter has numerous publications (109) and patents (24) in these areas.

The materials and processes invented have been integrated into manufacturing environments in conjunction with workers in IBM’s development and manufacturing divisions. Dr. Carter took a one‐year (1998‐99) internal assignment to IBM Laboratory Senior Technical Staff, a position with the responsibility of lab‐wide research strategy and planning. Dr. Carter has served as Chair of the ACS Division of Polymer Chemistry (2000‐2004) and used the position to strengthen ties to NOBCChE including assistance with organizing and instructing at the NOBCChE Science Academy for Young Students program at Cal State ‐ Hayward. He serves on the editorial advisory board of the ACS journal Chemistry of Materials. Prior to moving to academia, he worked in a collaborative fashion with researchers in academia including the coordination of projects that were either fully or partly funded by government‐awarded contracts. Project‐level management skills include the supervision of other scientists ranging from technicians to Ph.D. level scientists.

Since joining the faculty at UMass, Ken was a co‐leader in the establishment of the University of Massachusetts Nanoimprint Lithography Laboratory and is a Test Bed Project coordinator for the new NSF ‐ funded NSEC – Center for Hierarchical Manufacturing at UMass. He is currently the Associate Director for Research of the UMass Materials Research Science & Engineering Center on Polymers (MRSEC). His teaching interests include graduate‐level courses in polymer synthesis and special topics courses in polymers for lithography, conducting / semiconducting polymers, polymer surface modification and photopolymerization.

Ken and his wife Kim live in the town of Hadley in Western Massachusetts and enjoy travel and have been fortunate enough to visit some interesting spots around the globe during various international conferences and events. Ken still enjoys hamming it up playing bass and writing music in his spare time.

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Tuesday, PM

GEM Workshop 1:45 – 3:00 PM ʺ Graduate School Survival Tipsʺ

Room 411

Sibrina Nichelle Collins, PhD A proud native of Detroit, Michigan, Sibrina Collins is an organometallic chemist and earned her Ph.D. from The Ohio State University (2000) under the direction of Professor Bruce Bursten. Her research efforts focused on the low temperature matrix photochemistry of ruthenium cyclopentadienyl dicarbonyl dimers.

She later completed a postdoc in the Department of Chemistry at Louisiana State University with Professor Isiah Warner. Between 2003 and 2006, Dr. Collins was an assistant professor of chemistry at Claflin University, an HBCU located in Orangeburg, South Carolina. Her research efforts at Claflin University focused on the crystal‐engineering of metal‐organic frameworks (MOFs), which have many potential applications as electronic materials and hydrogen‐storage. Dr. Collins has also worked as a writer and editor (Minority Scientists Network) for the American Association for the Advancement of Science (AAAS) in Washington, DC. Since May 2006, she has served as the University of Washington’s Director of Graduate Diversity Recruiting.

Marcus Huggans, Ph.D., Senior Recruiter and Programs Specialist, The National GEM Consortium, Notre Dame, IN Marcus Huggans, Ph.D., is a native of St. Louis, Missouri. Marcus completed his engineering studies at the University of Missouri‐Rolla. He received a BS degree in Electrical Engineering in 1996, an MS in Engineering Management in 1997, and a Ph.D. in Engineering Management in 1998. He was one of the first African‐American males to earn a Ph.D. in this discipline from the University. For his his Ph. D. dissertation, Huggans conducted a study to determine if different Internet‐based study aids helped students of different learning styles under the advisors Dr. Halvard E. Nystrom and Dr. Harvest L. Collier. The title of his dissertation was “The Impact of Learning Styles Using Web‐based Asynchronous Distance Learning to Enhance Instruction by Electrical Engineering Students.” His findings indicate that not everyone thinks and learns in the same way and being aware of the variations in learning styles can help professors improve their teaching environment and students test scores. Marcus conducted his research as a GEM fellow through the National Consortium for Graduate Degrees for Minorities in Engineering and Science Inc, sponsored by Texas Instruments.

Dr. Huggans has had a variety of job opportunities. He has worked for 3M Company, AT&T Bell Laboratories, Department of Justice‐Federal Bureau of Investigation (FBI), and Texas Instruments Inc (TI). He began his professional career at TI in 1996 as an intern in 88

CONFERENCE SPEAKERS the Digital Light Processing Group where he was a software engineer. Marcus developed C algorithms to test the color integrity of DMD projectors to enable them to handle hue transitions. In December of 1998, Marcus joined TI full‐time as a member of the Technical Sales Associate program. He has worked in Technical Training Organization (TTO) developing technical workshops for Digital Signal Processors (DSP) customer and catalog products. He has also worked as a Technical Information Specialist in the Product Information Center (PIC) supporting customers worldwide.

Dr. Huggans transitioned from Technical Sales to Strategic Marketing/New Product Development for the PanelBus Division in May 2000 where he helped evaluate and influence TI’s next generation features that will power display technologies like HDTVʹs, LCD Monitors, and Digital CRTs. Finally at TI, he worked in an applications engineering role for four years evaluating consumer electronics and multi‐media IEEE 1394 products and supporting US and international customers. Dr. Huggans ran his own real estate company while teaching Marketing, Management, and Mathematics at the University of Phoenix. Dr. Huggans also worked at the University of Missouri‐Rolla (UMR) as the Director of the Student Diversity and Academic Support Program. Under his leadership, UMR has experienced unprecedented growth in the recruitment of under‐represented minorities students in the areas of science and engineering. Currently, he works for the National GEM Consortium (GEM) under the direction of Ms. Michele Lezama. At GEM, Dr. Huggans recruits and conducts programming to encourage under‐represented minority students to pursue their graduate degrees in science, technology, engineering, and applied mathematics (STEM) fields.

Currently, Dr. Huggans resides in Dallas, TX where he is happily married to his lovely wife Melanie, and he is a proud father of his daughter Hannah and son Ellis. In his spare time, he enjoys attending church, working with elementary, high school, and college students, and studying various investment vehicles. He also enjoys real estate investing, stocks and options, and entrepreneurship. Dr. Huggans believes that all individuals need to take control of their financial future. It is not the vehicle that will make you financially independent; it is the dedication to it.

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Tuesday, PM

NOBCChE Health Symposium 4:00 – 6:00 PM

Salon G

Sponsored by Eli Lilly and Company Dr. Gail H. Cassell

Dr. Gail H. Cassell is currently Vice President, Scientific Affairs and Distinguished Lilly Research Scholar for Infectious Diseases, Eli Lilly and Company in Indianapolis, Indiana. She is the former Charles H. McCauley Professor and Chairman of the Department of Microbiology at the University of Alabama Schools of Medicine and Dentistry at Birmingham, a department which ranked first in research funding from the National Institutes of Health during the decade of her leadership. She obtained her B.S. from the University of Alabama in Tuscaloosa and in 1993 was selected as one of the top 31 female graduates of the 20th century. She obtained her Ph.D. in Microbiology from the University of Alabama at Birmingham and was selected as its 2003 Distinguished Alumnus.

She is a past President of the American Society for Microbiology (the oldest and single largest life sciences organization with a membership of over 42,000). She was a member of the National Institutes of Health Directorʹs Advisory Committee and a member of the Advisory Council of the National Institute of Allergy and Infectious Diseases of NIH. She was named to the original Board of Scientific Councilors of the Center for Infectious Diseases, Centers for Disease Control and served as Chair of the Board. She recently served a three‐year term on the Advisory Board of the Director of the Centers for Disease Control and as a member of the Secretary of Health and Human Services Advisory Council of Public Health Preparedness. Currently she is a member of the Science Board of the Federal Food and Drug Administration Advisory Committee to the Commissioner. Since 1996 she has been a member of the U.S.‐Japan Cooperative Medical Science Program responsible for advising the respective governments on joint research agendas, (U.S. State Department/Japan Ministry of Foreign Affairs). She has served on several editorial boards of scientific journals and has authored over 250 articles and book chapters. Dr. Cassell has received national and international awards and an honorary degree for her research in infectious diseases. She is a member of the Institute of Medicine (IOM) of the National Academy of Sciences and is currently serving a 3‐year term on the IOM Council, the governing board.

Dr. Cassell has been intimately involved in establishment of science policy and legislation related to biomedical research and public health. For nine years she was chairman of the Public and Scientific Affairs Board of the American Society for Microbiology; has served as 90

CONFERENCE SPEAKERS an advisor on infectious diseases and indirect costs of research to the White House Office of Science and Technology Policy, and has been an invited participant in numerous Congressional hearings and briefings related to infectious diseases, anti‐microbial resistance, and biomedical research. She has served two terms on the LCME, the accrediting body for U.S. medical schools as well as other national committees involved in establishing policies in training in the biomedical sciences. She has just completed a term on the Leadership Council of the School of Public Health of Harvard University. Currently she is a member of the Executive Committee of the Board of Visitors of Columbia University School of Medicine, is a member of the Board of Directors of the Burroughs Wellcome Fund, and the Advisory Council of the School of Nursing of Johns Hopkins.

Gary J. Bell, MSW, LCSW, BCD

Mr. Bell was hired in February 1996 to fill the Executive Director position at BEBASHI. Mr. Bell has a Bachelors Degree in Psychology from Bucknell University and a Masters Degree in Social Work from the University of Pennsylvania. He is also a state‐licensed clinical social worker with a private practice in Plymouth Meeting.

Previously, he was employed for over 16 years at Episcopal Community Services (ECS), most recently as the Director of Adult Services where he managed a department of 75 employees while overseeing its homeless, older adult, AIDS and counseling services to 800 clients annually.

At ECS, Mr. Bell was largely responsible for building a home care program for the elderly from one homemaker and two social workers to over 40 home care staff. He was also integral in developing one of the largest AIDS programs in the Commonwealth of Pennsylvania that included homemaker service, visiting nurses, home delivered meals, case management, counseling, support groups, medical transportation, and an emergency food cupboard. One of his greatest accomplishments at ECS was the development of the STARR (Supportive Therapy for AIDS Affected Relatives) program. At the time, STARR was the only program in Philadelphia that provided individual and family counseling and support groups targeting children affected by HIV/AIDS.

Despite formidable obstacles awaiting Mr. Bell at BEBASHI, he has been able to make tremendous strides in improving program and service delivery, developing greater fiscal controls, upgrading the computer system, initiating new service programs and collaborative efforts, and revitalizing the Board of Directors. He has strengthened relationships with other community leaders as well as developed funding support from various pharmaceutical companies and foundations.

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During the past nine years of Gary Bell’s leadership, he has not only enhanced the existing programs of prevention education, case management, HIV, STD and pregnancy counseling and testing, he has also implemented several innovative programs that include a women’s initiative, an emergency food cupboard, weekly support groups, and initiated one of the only discharge planning programs for HIV+ ex‐offenders in the country!

SUMMARY OF EXPERIENCE:

Mr. Bell has over twenty years of management and direct human services/non‐profit experience in Home Health, Therapeutic Counseling, Case Management, Volunteer and Nutrition programs. He has strong planning, program development and proposal writing skills and he has managed programs funded by third party insurance and managed care organizations. In addition, Mr. Bell has managed multiple programs serving diverse client populations, such as elderly, homeless families, abused and neglected children, and persons with HIV/AIDS disease.

Dr. Carol Germaine,

Carol is the biology program manager for Research & Development Informatics at Pfizer in La Jolla, CA. She has an extensive background in pharmaceutical research information systems. Carol holds a BS in microbiology, an MS in biostatistics from the University of Michigan and has worked toward a PhD in epidemiology. She evaluated the data collection systems at Kakuma Refugee Camp in Kenya that monitor the International Rescue Committeeʹs Integrated Community‐Based HIV/AIDS Program.

Dr. Pamela A. Clax Dr. Clax’s experience spans the public and private sectors in the diagnostic, pharmaceutical, biomedical research and medical fields. While working in the private sector, she gained experience in the Quality Assurance (as a laboratory technologist), Research and Development (as an assistant scientist) and Manufacturing Divisions of Ortho Diagnostic Systems, Inc. (a subsidiary of Johnson & Johnson, Corporation), as a Clinical Trials Specialist for Social and Scientific Systems, Inc., and as a Clinical Research Associate for Ayerst Laboratories (an American Home Products company). In addition, she served as Chief Podiatric Medical Resident while completing her residency program. All of these positions entailed balancing scientific or medical skills with management skills.

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CONFERENCE SPEAKERS Her experience in the public sector has been at the National Institutes of Health, the NIAID as a Special Assistant to the Assistant Director of Clinical Research‐TRP and Medical Monitor in the Division of AIDS. While participating in the Management Cadre Program, she completed a variety of management and professional development courses that have (further) broadened and reinforced my management experience. The most significant experiences in this program for me were detail assignments conducted in the offices under the Office of the Director of NIH. Most notably, she played an active role in the preparation for one of the NIH Directorʹs Leadership Forum sessions, and Office of Science Policy (and Office of Science Policy and Planning) activity.

Pamela Clax earned a Bachelor of Arts Degree in Biological Sciences from Rutgers, the State University, New Brunswick, N.J. Her Doctorate of Podiatric Medicine was obtained at New York College of Podiatric Medicine, New York, New York , and was followed with a Certificate of Residency: Podiatric Medicine and Surgery from Southwest Detroit Hospital, Detroit, MI

Dr. Arlene Bardeguez

Dr. Bardeguez practices Maternal and Fetal Medicine and Obstetrics & Gynecology in Newark, New Jersey. She is also a professor of Obstetrics & Gynecology at the University of Medicine and Dentistry of New Jersey. As the director of HIV services for the University Hospital in Newark, she focuses on pediatric AIDS cases involving pregnant women who were affected with HIV. She has served as a member of The Office of AIDS Research Advisory Council (OARAC) since 2005.

Dr. Arlene Bardeguez graduated from the University of Puerto Rico School of Medicine in 1981 with an MD and has been in the profession for 27 years. She completed her residency in Obstetrics & Gynecology at the Catholic Medical Center, Jamaica, NY, 1981‐1985.

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Wednesday, AM

Plenary IV – Jumpstarting Your Career Breakfast Served 7:30 AM ‐ 9:00 AM Sponsored by Rohm and Haas Company

Salon H

Cathie Markham, Vice President of Technology and Chief Technology Officer Rohm and Haas Company

Cathie Markham was named Vice President of Technology in 2004 and Chief Technology Officer of Electronic Materials in 2006. She joined Rohm and Haas in 2002 as Director of Pad Technology with 20 years of experience in the petrochemical industry including managing Research and Development, global technical service, engineering, new business development and leading organizational improvement activities. Cathie became VP of Technology in 2004 responsible for Chemical Mechanical Planarization (CMP) product research, development, scale‐up and technical service. In 2006, she assumed Chief Technology Officer responsibilities for the Electronic Materials portfolio. Cathie earned a bachelor’s degree in chemical engineering from the Massachusetts Institute of Technology.

She has authored multiple papers and patents, is a member of the AIChE, and serves on the executive committee for the CMP Conference.

Rohm and Haas Leading the way since 1909, Rohm and Haas is a global pioneer in the creation and development of innovative technologies and solutions for the specialty materials industry.

The company’s technologies are found in a wide range of industries including: Building and Construction, Electronics and Electronic Devices, Household Goods and Personal Care, Packaging and Paper, Transportation, Pharmaceutical and Medical, Water, Food and Food Related, and Industrial Process. Innovative Rohm and Haas technologies and solutions help to improve life every day, around the world. Based in Philadelphia, PA, the company generated annual sales of approximately $8.9 billion in 2007. Visit www.rohmhaas.com for more information. imagine the possibilities™

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Franklin 1 Professional Development Workshop 10:00 AM – 11:00 AM “Our Chemistory: Celebrating Our History in The Chemical Sciences”

Wednesday, AM

Dr Sibrina Collins See page 86

Dr. Anthony L. Dent’s career over the past 40 years includes a number of first time accomplishments. After graduating cum laude from Morgan State College (currently Morgan State University) in 1966 with a BS degree in chemistry, he enrolled in the Ph.D. program in the chemistry department of The Johns Hopkins University. He became the first Morgan State chemistry major to enter Hopkins’ graduate program. By the Spring of 1970, he had completed the doctoral degree requirements in physical chemistry and became the first African‐American to receive a doctoral degree in chemistry from The Johns Hopkins University. During his Hopkins period, he co‐authored 10 technical papers with R. J. Kokes on the topic of infrared evidence for adsorbed species. These publications provided the first ever physical evidence for adsorbed reaction intermediates during a heterogeneously catalyzed reaction. While at Johns Hopkins, he was inducted into Phi Beta Kappa and Phi Lambda Upsilon honor societies.

His professional career continued at Carnegie‐Mellon in 1970 with an appointment as an Assistant Professor in the Chemical Engineering Department. He was the first African‐ American professor hired into CM‐U’s School of Engineering. He was promoted to the rank of Associate Professor in that department in 1975. At C‐MU his research focused on applying chemical kinetics and infrared spectroscopy to study adsorbed species. While at Carnegie‐Mellon, he was inducted into the Society of Sigma Xi.

In 1979, he joined the PQ Corporation’s R&D Center in Conshohocken, PA, as a senior chemist. He was promoted through the management and technical ranks to senior research fellow. His specialized expertise includes catalyst characterization, silica gel synthesis and characterization, catalyst preparation, sol ‐ gel technology, polymerization catalyst testing, zeolite and silica extrusion technology. He developed the companyʹs technical basis (catalyst support and catalyst manufacturing) that led to a $70 million silica catalyst business for High Density Polyethylene (HDPE). He provided technical project coordination from conceptualization through commercialization, and he successfully supervised the initial commercial catalyst production runs for all new HDPE catalysts.

Tony retired from PQ in 2000 after more than 20 years. Dr. Dent is currently an adjunct professor in the Science & Allied Health Department at Cheyney University of Pennsylvania where he teaches Calculus based Physics.

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CONFERENCE SPEAKERS Tony is a long time NOBCChE member who has been active at the local, regional, and national levels. He was the first president of the Delaware Valley Chapter, then the Northeast Regional Chair before his election for two terms to the National board as a director – at ‐ large. He chaired the National Science Bowl/ Science Fair Committee, and he is a member of the Website committee, and he serves as editor of the NOBCChE News Magazine that is published quarterly on‐line. He has served as Printed Materials Chair of the Annual Planning Committee for the past 4 years. As the NE Chairperson, he inspired the NOBCChE Science Bowl Competition that has grown to involve over 1,000 junior and senior high school students across the country.

Dr. Dent is also a member of the American Chemical Society. He has served in leadership positions with several other organizations. He was Secretary/Treasurer (1983–85), Chair‐ Elect (1989‐90), Chair (1990‐91), and Director (1988‐89, 92‐94) of the Philadelphia Catalysis Club and Chair (1975‐76) of the Pittsburgh Catalysis Society.

Dr. Dent is the author of approximately 20 publications that have appeared in scientific and technical journals; he holds 4 US Patents. His biography appears in American Men and Women in Science and Whoʹs Who Among Black Americans. Tony and his wife, Joyce Chesley‐Dent, reside in Dresher, PA.

Technical Session 11

Thursday, AM 9:00 AM – 11:05 AM Room 410 Lloyd Ferguson Young Scientist Award Recipient

Andre F. Palmer is currently Associate Professor of Chemical and Biomolecular Engineering at The Ohio State University. Prior to this appointment, Prof. Palmer served as Assistant Professor of Chemical Engineering at the University of Notre Dame, and Assistant Professor of Chemistry at Howard University.

Prof. Palmer received his Ph.D. in Chemical Engineering from The Johns Hopkins University in 1998. His research interests encompass the development of novel hemoglobin‐based oxygen carriers for a variety of transfusion applications and the use of these oxygen carriers to enhance and target oxygen delivery to mammalian cell cultures. He is author of more than 37 peer reviewed publications. Among others, he received the National Science Foundation Career Award in 2001, and two National Institutes of Health R01 grants in 2006. Prof. Palmer previously served on the editorial board of the American Society for Artificial Internal Organs Journal, and is currently an editorial board member for the Journal of Artificial Cells, Blood Substitutes and Biotechnology. Prof. Palmer also serves on the International Scientific Advisory Committee on Blood Substitutes, and is a member of 96

CONFERENCE SPEAKERS the Academic Advisory board for the Department of Chemical Engineering at Howard University.

Prof. Palmer is married to attorney Allison Lowery Palmer. They have a son, Alexander, and a daughter, Alyssia.

Thursday, AM

Technical Session 12 9:00 AM – 11:00 AM NOBCChE Professional Chemical Engineering Awardee

Room 407

Christine S. Grant, Ph.D. Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC

Credit: Jack Hartzman

Dr. Christine Grant is a tenured Full Professor of Chemical and Biomolecular (CBE) engineering at North Carolina State University (NCSU). She obtained a Bachelors degree in Chemical Engineering from Brown University in 1984; her graduate degrees (M.S. and Ph.D.) were both obtained from Georgia Institute of Technology in 1986 and 1989. She joined the NCSU faculty in 1989 after completing her doctorate and has moved through the ranks of Assistant and Associate to Full Professor – one of only 3 African‐American women in the U.S. at that rank. Her research focuses on surface and interfacial phenomena in the areas of electronic materials and polymers. She has served her profession as a leader in the American Institute of Chemical Engineers (AIChE) as a member of both the Board of Directors and the Chemical Technology Operating Council. Starting in 2008, Grant will serve as an Associate Dean of Faculty Development and Special Initiatives at NCSU. Grant, an NSF Presidential Award for Excellence in Science, Math and Engineering Mentoring (PAESMEM) awardee, was recently selected as a Boeing Senior Fellow of the National Academy of Engineering’s Center for the Advancement of Scholarship on Engineering Education (CASEE). As a Boeing Fellow her project involves strategic planning, and infrastructure development to catalyze existing resources and develop new resources to enhance the recruitment, retention, and advancement of faculty drawn from underrepresented minority (URM) populations in engineering and science. A critical aspect of her project is to develop a strong collaborative effort between university 97

CONFERENCE SPEAKERS administrators (e.g., engineering deans, department heads) and senior URM faculty in engineering and science that will address this opportunity based on the wisdom of their own experiences. She recently founded the “Promoting Underrepresented Presence on Science and Engineering Faculties (PURPOSE) Institute”. PURPOSE is the culmination of Grant’s over 20 years working on the development of URM scientists and engineers. She has been a co‐facilitator of an active network of chemical engineering faculty through: leadership of the Minority Affairs Committee in AIChE, organization of NSF workshops for minority engineering faculty, and numerous presentations as a speaker or a panel member for programs focused on excellence in the academy. Her progress in this arena was recently recognized with the AIChE Minority Affairs Committee Distinguished Service Award. She received a Theophilus Sorrell Graduate Fellowship in 1987, the Lloyd Fergusson Award in 1997 ; both from NOBCChE. As one of less than ten tenured female African‐American chemical engineering faculty in the nation, Grant is working to change the under‐ representation of minorities on engineering and science faculty through targeted mentoring of both women and URM students and faculty.

Thursday, PM

Science Competition Special Event 6:00 PM – 7:00 PM

Speaker

Tyraine ʺGrand Hankʺ Ragsdale

Salon H

Tyraine Ragsdale (a.k.a. Grand Hank) is the founder and president of Grand Hank Productions Incorporated (GHPI). Prior to heading this organization, Grand Hank was a research chemist for the R.W. Johnson Pharmaceutical Research Institute Division of Johnson & Johnson. Grand Hank is a graduate of the University of Pittsburgh with a degree in Chemistry. His scientific background has given him a leading edge in todayʹs technology and insight on how to organize ideas in ways that encourage others. At the same time he possesses writing, music and television production backgrounds, which allow him to create programs and products that appeal to all audiences.

Since GHPI’s inception in 1989, Grand Hank has impacted millions of students, parents and educators across the United States. Some of Grand Hank’s notable contributions to the field of science education are: co‐creating the “Science of Philadelphia” and the “Science Lab of Grand Hank” television shows which are broadcast in Pennsylvania, New Jersey, Delaware and Maryland; co‐developing the Science Core Curriculum for the School District 98

CONFERENCE SPEAKERS of Philadelphia for grades K‐8; Developing the science curriculum for State Representative Chaka Fattah’s mobile Science Learning Lab; and opening up a 5000 Sq. Ft., state‐of‐the art science laboratory and event center, complete with a film and television production studio.

Most recently, Grand Hank created the 1st Annual Black History Month Science Field Trip “Celebrating African‐American Scientists and Inventors Through Live Science Demonstrations,” for students in grades 4 – 8.

Grand Hankʹs commitment to moving science education to a new level has not gone unrecognized. He is often invited to present by distinguished organizations such as: The National Organization for the Professional Advancement of Black Chemist and Chemical Engineers, The National Education Association, The National Science Teachers Association, The National Alliance of Black School Educators, and The American Chemical Society.

Grand Hank has also been featured in local and national newspapers and magazines, and has appeared on numerous radio and television talk shows.

As a scientist, educator and entrepreneur, Grand Hank knows the importance of increasing student’s interest in pursuing careers in science. The commitments to science education, as well as providing positive role models for our children are the cornerstones of Grand Hank’s personal mission.

Friday, PM

Speaker

Science Competition Awards Luncheon 11:45 PM – 2:00 PM

Salon H

Dr. Gloria T. MaGee, Assistant Professor of Chemistry Xavier University, New Orleans, LA

Dr. Gloria Thomas MaGee received a bachelorʹs degree in chemistry in 1996 from Southern University and A&M College in Baton Rouge, LA, where she was both Timbuktu Academy and Packard Foundation Scholars. During her undergraduate years, she participated in several internships at The Upjohn Company (Kalamazoo, MI) and Albemarle Corp. (Baton Rouge, LA). MaGee also worked in the chemical industry for a brief period before earning a doctorate in chemistry at Louisiana State University in 2002 as a Louisiana Board of Regents and American Association of University Women Fellow. MaGee was a National Research Council Postdoctoral Fellow at the National Institute of Standards and Technology (2002 – 2003) and an Assistant Professor at Mississippi State University (2003 – 2007). She is now an Assistant Professor at Xavier University in New Orleans.

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CONFERENCE SPEAKERS Dr. MaGee is the 2007 Chair of the National Science Foundation Chemistry Division Leadership Group for the Research Experiences for Undergraduates (REU) Program, is a member of the Executive Board of the National Organization of Black Chemists and Chemical Engineers (NOBCChE), and is actively involved in the American Chemical Society (ACS) as the National Meeting Activities Sub‐committee Chair of the Younger Chemists Committee. In each of these roles, Dr. MaGee is passionate about broadening the participation of underrepresented groups in the chemical sciences and sharing her personal experiences. She has also worked with at‐risk youth through groups such as the Research and Engineering Apprenticeship Program, Court Appointed Special Advocates (for foster children), the Girl Scouts of America and Masonic organizations. Her experiences have been honored as 2007 recipient of the Stanley C. Israel Award for Advancing Diversity in the Chemical Sciences.

Dr. MaGee’s professional interests include bioanalytical applications of electrophoresis and microdevice technology, and new technologies and strategies in chemical education. She also enjoys photography and iEverything.

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Monday, AM

Technical Session 1

10:00 AM – 12:00 N

Inorganic Chemistry Room 410 Session Chair Kenneth Hicks Department of Chemistry, Norfolk State University Presenters

“Investigative Studies Of The Reduction Of A Series Of Mo(VI)‐ 10:00 AM – Ligand Complex Using UV‐Vis, FT‐IR, And FT‐NMR Spectroscopy” 10:20 AM

Josiah Wrensfort1, Alicia Kelly1, Juan Miguel Maldonado1, Olivia Penrose2, Clifford F. Denize2, Doreen O. Jackson2, and Kenneth W. Hicks*2.

Department of Biology1 and Department of Chemistry2, Norfolk State University, 700 Park Avenue, Norfolk, VA

Abstract

The main objective of the research is to investigate the mechanism of chemical reduction of a series of molybdenum(VI)‐ligand complexes and to devise methods to understand the reduction of the monomeric Mo(VI)‐ligand complexes to the Mo(V)‐L dimer by the reducing agent, sodium dithionite. The research is part of an attempt to prepare a series of dimeric Mo2O4‐L complexes with ligands at specific coordination positions. Solutions of molybdenum(VI)‐L complexes were prepared using glycine (Gly), N‐(phosphonomethyl) iminodiacetic acid (PMIDA), nitrilotriacetic acid (NTA), chelidamic acid (ChLDA), hydroxyethylenediaminetriacetic acid (HEDTA), and ethylenediaminetetraacetic acid (EDTA). The pH of the Mo(VI)‐L solutions were adjusted to 6.2 ‐ 6.5 with NaOH or NaOD. Data was obtained via the use of UV‐Vis, FT‐IR and FT‐NMR instrumentation. The spectral results showed the decrease of a peak associated with the monomeric Mo(VI)‐L complex and the growth of peaks taken to represent the presence of the Mo(V)‐L or Mo(V)‐L2 dimer.

The presentation will propose a reaction mechanism for the transformation of the monomeric MoO3‐L complexes to the dimeric Mo2O3‐L, Mo2O4‐L or Mo2O4‐L2 complexes.

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TECHNICAL ABSTRACTS 10:20‐10:40

“Synthesis And Reactivity Of High Oxidation Organometallic Palladium And Platinum Complexes”

Salena R. Whitfield* and Melanie S. Sanford University of Michigan, Department of Chemistry, Ann Arbor, MI Abstract

The oxidation of PtII(phpy)2 (phpy = 2‐phenylpyridine) with three different electrophilic chlorinating reagents – PhICl2, N‐chlorosuccinimide (NCS), and AuCl(SMe2) – will be described. Under all conditions examined, PtII(phpy)2 reacts with PhICl2 to afford a mixture of cis and trans isomers of PtIVCl2(phpy)2. This transformation is believed to proceed by a two‐step two‐electron mechanism, involving initial formation of [ClPtIV(phpy)]+ followed by trapping of this intermediate with Cl–. In contrast, oxidation of PtII(phpy)2 with NCS or AuCl(SMe2) afforded mixtures of PtIII and PtIV products, whose structures and ratios varied dramatically as a function of solvent, reaction time, concentration, and the presence/absence of ambient light. The origin of these variations will be discussed and is rationalized based on several different one‐ and two‐electron oxidation pathways.

The oxidation of PdII(phpy)2 with electrophilic chlorinating reagents – particularly PhICl2 and N‐chlorosuccinimide (NCS) – will also be discussed. Oxidation of these complexes affords stable PdIV species as the major products, including a novel PdIV complex resulting from oxidative addition of N‐chlorosuccinimide (NCS). The PdIV complexes undergo competing C–C, C–N, and C–Cl bond‐forming reductive elimination reactions.

The product distributions in these transformations vary dramatically as a function of solvent. The mechanisms of reductive elimination will be discussed based on these results.

10:40 AM – 11:00 AM

“Palladium‐Mediated Halogenation Of Carbon‐Hydrogen Bonds”

Nicholas D. Ball, Melanie S. Sanford*

Department of Chemistry, University of Michigan, Ann Arbor, MI

Abstract Directed palladium‐catalyzed halogenation of C–H bonds has been previously reported by our laboratory and has been proposed to proceed through an unusual Pd(II)/Pd(IV) mechanism. Key to the proposed mechanism is the existence of a monocyclometalled Pd(II) intermediate, which undergoes oxidative addition and subsequent reductive 102

TECHNICAL ABSTRACTS elimination. This presentation will discuss the creation of Pd(bzq)(X)(L) complexes where X = F, Cl, Br, I, L = a pyridine derivative , and Bzq = Benzoquiniline, and their reactivity with stoichiometric N‐halosuccinimide oxidants. The product distribution of these reactions will demonstrate the validity of these intermediates in a Pd(II)/Pd(IV) catalytic cycle. In particular, the oxidation of cis and trans palladium fluorine complexes with electrophillic fluorinating agents, N‐fluoropyridium salts and XeF2 will be discussed.

Their relative reactivity, stability, and ability to form C–F bonds will be explored to examine the viability of Pd(II)/Pd(IV) C–F bond formation in catalytic systems.

Break 11:00 AM – 11:05 AM

“Spectroscopic And Computational Studies Of Nickel Superoxide 11:05 AM – Dismutase: Roles Of The Cysteine‐2 And ‐6 Active Site Ligands ” 11:25 AM Olivia E. Johnson1, Thomas Brunold1* 1Department of Chemistry, University of Wisconsin‐Madison, Madison, WI Abstract A recently discovered class of superoxide dismutases containing nickel (NiSOD), from Streptomyces spp. , has been shown to protect certain aerobic organisms from oxidative stressed by catalyzing the disproportionation of the superoxide radical. The general mechanism of NiSOD involves the reduction of superoxide by the reduced (i.e., Ni2+‐ bound) enzyme to hydrogen peroxide and the subsequent oxidation of a second substrate molecule by the oxidized (Ni3+‐bound) enzyme to molecular oxygen. Previous spectroscopic and computational studies of NiSOD led to the proposal that the equatorial thiolate ligands derived from the cysteine‐2 and ‐6 residues greatly destabilize the nickel 3d‐based molecular orbitals, so as to facilitate electron transfer from the Ni2+ ion to the substrate superoxide. Because of the obvious importance of the cysteine ligands with regards to metal ion redox tuning and to understand how the NiSOD active site protects these ligands from oxidative damage caused by the superoxide radical, we have initiated a combined spectroscopic and computational study of various NiSOD mutants that lack one or both of the cysteine residues. Significantly, our data reveal that elimination of a single cysteine residue is sufficient to abolish catalytic activity and to drastically alter the electronic structure of the active site, causing the Ni2+ ion to adopt a high‐spin configuration as opposed to the closed‐shell configuration observed for the native enzyme.

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TECHNICAL ABSTRACTS 11:25 AM – 11:45 AM

“1.54 μM Emission Characteristics In Highly Crystalline Er:Zno Films Synthesized By Pulsed‐Laser Deposition”

L. Douglas, H. Mustafa, R. Mundle, C.E. Bonner, and A.K. Pradhan

Center for Materials Research, Norfolk State University, 700 Park Avenue, Norfolk, VA Abstract We report on the fabrication of high‐quality Er:ZnO films by the pulsed‐laser deposition technique at high temperature followed by insitu‐annealing. The films demonstrate remarkable crystalline quality and contain self‐assembled grains. Although the films show very low electrical resistivity (~6.41 x 10‐4 μ‐cm) at room‐temperature, a semiconductor‐ metal transition was observed at 190 K. The films show pronounced room‐temperature emission characteristics at 1.54 μm, illustrating the activation of Er3+ ions in ZnO matrix.

Furthermore, no quenching effects in PL characteristics at 1.54 μm were observed up to 2 wt % of Er‐doping in ZnO at room‐temperature.

11:45 AM – Poster Talk “Titanium Catalyzed 3‐Component Coupling & Intramolecular 11:50 AM

Asymmetric Hydroamination Of Aminoalkenes” Kevin R. Gipson1, Aaron L. Odom*2, Supriyo Majumder3 Michigan State University , Department of Chemistry, East Lansing, MI Abstract Asymmetric hydroamination of amimoalkenes is an efficient and atom‐economical process to produce enantiomerically pure pyrrolidines. Pyrrolidines are important from the pharmaceutical perspective. We have synthesized a new chiral ligand by the condensation reaction between 2, 2’ diamino‐1‐1’ binapthalene and 2‐formyl‐5 mesityl pyrrole. The catalysts are made by reacting the chiral ligand with TiCl4 and also with ZrCl4. Currently we are in the process of probing the activity of these two catalysts. We are also looking at ways to generate a new cationic complex for their use in asymmetric hydroamination reaction.

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Monday, AM

Session Chair

10:00 AM – 10:30 AM

Technical Session 2

10:00 AM – 12:00 N Franklin 1 Biochemistry and Biotechnology Applications Holly Cymet Department of Chemistry, Morgan State University Presenters

Highlighted Speaker “Taking A Hit For The Team: Self‐Sacrifice As An Enzymatic Strategy In The Biosynthesis Of Lipoic Acid” Squire J. Booker

Associate Professor of Biochemistry and Molecular Biology, Penn State University Abstract Lipoic acid is an eight‐carbon straight‐chain fatty acid containing sulfur atoms at carbons 6 and 8. In addition to its antioxidant properties, its most notable function is as a key cofactor that is employed by several multienzyme complexes that are involved in energy metabolism (pyruvate dehydrogenase and ‐ketoglutarate dehydrogenase complexes), or the catabolism of glycine (glycine cleavage system), branch‐chain amino acids (branch‐ chain amino acid dehydrogenase complex), and acetoin (acetoin dehydogenase complex).

In its role as a cofactor, it must be attached covalently in an amide linkage to the epsilon nitrogen of a specific lysine residue on a lipoyl carrying protein of the complex. This important post‐translational modification can be achieved via two different mechanisms: one in which exogenous intact lipoic acid is activated and then appended to a lipoyl carrying protein, and one in which lipoic acid is constructed de novo in its cofactor form onto a lipoyl carrying protein.

This lecture will describe the characterization of lipoyl synthase, which catalyzes the terminal step in the de novo pathway for the biosynthesis of the lipoyl cofactor, which is the insertion of sulfur atoms at carbons 6 and 8 of an n‐octanoyl chain that is covalently bound to lipoyl carrying proteins. Lipoyl synthase is a member of the radical‐SAM superfamily of enzymes, wherein S‐adenosylmethionine is used to generate a 5’‐deoxyadenosyl 5’‐ radical, which is a required intermediate in catalysis. A working hypothesis for the role of the 5’‐deoxyadenosyl 5’‐radical will be presented, as will experiments that have been conducted to test that working hypothesis. Interestingly, data will be presented that indicate that the protein is both a catalyst and a substrate.

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TECHNICAL ABSTRACTS 10:30 AM – 10:45 AM

“Time Resolved UV Resonance Raman Studies of Nucleic Acid Base Stacking”

Alison Williams*1 and Ishita Mukerji2

1Princeton University, Department of Molecular Biology, Princeton, NJ 2Wesleyan University, Department of Molecular Biology and Biochemistry, Middletown, CT

Abstract

Time‐resolved UV resonance Raman spectroscopy is a powerful method for monitoring structural changes in real time. The technique permits the exploration of transient intermediates on a time scale inaccessible to NMR studies and at a level of sensitivity not possible via electronic spectroscopy. To date, studies have explored protein dynamics, yet nucleic acid structural features have yet to be investigated by this method. In this study, we report the results of time‐resolved UV resonance Raman spectroscopic studies of base stacking in polyriboadenylic acid (poly r(A)) in the nanosecond to microsecond timescale.

Preliminary results show that the kinetics of the associated conformational changes can be resolved; specifically, backbone conformational changes can be separated from those associated with the bases.

“Single Molecule Studies Of Lac Repressor‐Induced DNA Loops” 10:45 AM – 11:00 AM Kathy Goodson, Sara Lioi, Aaron Haeusler, Jason Kahn, Douglas English* University of Maryland, Department of Chemistry & Biochemistry, College Park, MD Abstract The Escherichia coli lactose repressor protein (LacI) represses expression of the lac operon.

In this system, the tetrameric protein binds a primary promoter‐proximal operator, O1, and two auxiliary operators, O2 and O3, in order to repress transcription of the lac operon.

Binding of these two sites to a single LacI molecule is facilitated by DNA loop formation.

Recently, we have measured the conformational homogeneity of the DNA looping seen in this system using single molecule fluorescence resonance energy transfer (SM‐FRET) and a model DNA construct, 9C14 (Biophys. J. 2005, 89, 2588). The model DNA sequence, 9C14, is a fluorophore‐labeled double‐stranded construct with a sequence induced bend flanked

by LacI binding sites. Along with other model sequences, 9C14 was used to demonstrate, through FRET analysis, that LacI may change conformation in order to form a particular 106

TECHNICAL ABSTRACTS loop structure. In our previous work, we showed that LacI forms a single, stable, rigid DNA loop despite the presence of flexible domains in LacI. When Isopropyl‐ ,D‐ thiogalactoside (IPTG), an alternative inducer to allolactose, binds to the repressor, the repressor changes conformation, causing it to have a lower affinity for DNA. In our current studies, SM‐FRET will be used to investigate LacI‐induced loop formation in 9C14 as a function of IPTG concentration. These 9C14/IPTG studies will provide insight into the precise role of small molecule inducers in gene regulation.

11:00 AM – 11:15 AM

“Solution Structure And Backbone Dynamics Studies Of An Oncogenic Mutant Of The Ras Protein Cdc42Hs Outlines The Molecular Basis Of Its Aberrant Cell Signaling”

Paul D. Adams*1 and Robert E. Oswald2

1Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 2Department of Molecular Medicine, Cornell University College of Veterinary Medicine, Ithaca, NY

Abstract Cdc42Hs(F28L) is a single‐point mutant of Cdc42Hs, a member of the Ras superfamily of GTP‐binding proteins whose structure has previously been solved by NMR spectroscopy (Feltham et al. (1997) Biochemistry 36, 8755‐8766), and the backbone dynamics characterized

by NMR spectroscopy (Loh et al. (1999) Biochemistry 38, 12547‐57). The F28L mutation results in cellular transformation brought about by an increased rate of cycling between GTP and GDP (Lin et al. (1997) Curr. Biol. 7, 794‐797). Multidimensional NMR spectroscopy was performed in this laboratory to characterize the solution structure and backbone dynamics of Cdc42Hs(F28L). The overall structure of Cdc42Hs(F28L) is very similar to Cdc42Hs wildtype, consisting of a centrally located six‐stranded ‐sheet structure surrounding the C‐terminal ‐helix. In addition, the same three regions in wildtype Cdc42Hs that show structural disorder (Switch I, II and the Rho insert region) are disordered in F28L as well. Chemical shift perturbation analysis suggested that very little structural change was evident outside of the nucleotide‐binding site. The structure did, however, reveal significant differences in residues comprising the nucleotide‐binding site, which may account for the fast cycling activity of Cdc42Hs(F28L), and hence, its transformation capability (Adams and Oswald (2006) Biochemistry 45, 2577‐2583). In addition, residues comprising the nucleotide‐binding site, as well as the nucleotide itself, exhibit increased dynamics over a wide range of time scales in Cdc42Hs(F28L) relative to wildtype. The changes in dynamics indicate a substantial disruption of the chemical environment within the nucleotide‐binding site of the Cdc42Hs mutant construct (Adams 107

TECHNICAL ABSTRACTS et al. (2004) Biochemistry 43, 9968‐9977). The solution structure and backbone dynamics of Cdc42Hs(F28L) will be described, which provides insight into the molecular basis for the change in affinity for GDP in this oncogenic Ras protein. In addition, a description of how the molecular changes introduced by the single point mutation affect important aspects of signaling processes, without disrupting the conformation of the whole mutant protein relative to the normal functioning wild type protein, will be discussed. Future directions of this work will also be presented.

“Role Of The Central Hydrogen‐Bonding Network Interdomain 11:15 AM – Residues In The Bifunctionality Of Catalase‐Peroxidases” 11:30 AM

Carma O. Cook and Douglas C. Goodwin Auburn University Department of Chemistry and Biochemistry, Auburn University, AL Abstract Catalase‐peroxidases (KatGs) are bifunctional enzymes composed of an N‐terminal domain, which contains the active site, and an “inactive” C‐terminal domain. Our previous investigations show that catalase‐peroxidase expressed without a C‐terminal domain (KatGC) lacks activity due to a structural collapse inside of the active site. To determine if these structural shifts and the corresponding loss of activity for the ʺstand‐ aloneʺ N‐terminal domain (KatGN) were reversible, we use deletion mutagenesis to separately express and isolate KatGC. KatGN reactivates upon incubation with equimolar concentrations of KatGC as the active site is restructured. A highly conserved hydrogen‐ bonding network is present between the C‐terminal domain and a loop connecting the B and C helices of the N‐terminal domain. Because the BC loop extends from the B helix, which is a major component of the KatG active site, these contacts between the BC loop and the C‐terminal domain may be essential for the structural integrity of this heme‐ dependent active site. Variants with substitutions of these residues were expressed for the separately isolated domains and their ability to support active site restructuring was evaluated by a variety of kinetic and spectroscopic techniques. Our data indicate that the residues on the periphery of the network are necessary for peroxidase activity, whereas those in the central part of this conserved hydrogen‐bonding network are significant for both catalase and peroxidase activities. These results implicate the central hydrogen‐ bonding network residues as having a role in properly orienting the BC interhelical loop on the N‐terminal domain for interaction with the C‐terminal domain to impart bifunctionality to the enzyme.

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TECHNICAL ABSTRACTS 11:30 AM – 11:45 AM

“Strucuture‐Based Discovery Of Novel LPA3 Antagonists”

James I. Fells, Sr.*1, Ryoko Tsukahara2, Jianxiong Liu2, Abby L. Parrill1, and Gabor Tigyi2

1Department of Chemistry and Computational Research on Materials Institute, The University of Memphis, Memphis, TN 2Department of Physiology, University of Tennessee Health Science Center, Memphis, TN

Abstract Lysophosphatidic acid (LPA) is one of the most studied phospholipids because of the numerous cellular responses that it invokes. LPA responses are mediated by its G‐ protein coupled receptors (GPCR), LPA1‐3. This bioactive mediator is linked to numerous diseases including various cancers and cardiovascular disease. Subtype‐specific molecules would serve as important tools in studying the role of LPA in these diseases. Here we describe the identification of selective LPA3 antagonists through the use of virtual screening tools. Virtual screening uses both structural and computational information to help guide experimental work. We have developed a structure‐based pharmacophore as a qualitative tool to identify selective antagonists. In addition we have begun developing a binary QSAR model as a quantitative tool. We have also employed similarity searching as a lead optimization technique. To date we have identified thirteen antagonists, two of which are selective antagonists.

Research supported by the Greater Southeast Affiliate of the American Heart Association (0715125B) and the National Heart, Lung and Blood Institute (R01 HL 084007).

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Monday, PM

Technical Session 3

1:45 PM – 3:45 PM Room 410 Henry McBay Outstanding Teacher Symposium – Chemical Education Session Chair John Harkless Department of Chemistry, Howard University Presenters

1:45 PM – Dr. Henry McBay Outstanding Teacher Awardee “Morgan´s CURE: Continuous Undergraduate Research Experience” 2:15 PM Alvin P. Kennedy Department of Chemistry, Morgan State University

“Action And Strategies For Improving Performance In General 2:15 PM – Chemistry At Florida A&M University” 2:35 PM

1Serena. Roberts, 2Jamar. Robinson, 2Antoinette. Addison, 3 Milagros Ignatz, 4Ruppert.

Giroux, 2Marc. Weininger, 2Reginald. Little, 2Bereket. Mochona, 1, 5Marcia. Owens, 2Modeline. Blanchard 2Jesse Edwards

1Teacher Learning Institute/Teachers for a New Era , 2Chemistry Department, , 3College of Education, 4Industrial and Manufacturing Engineering, FAMU/FSU College of Engineering, and 5Environmental Sciences Institute, Florida A&M University, Tallahassee, Florida

Abstract

The “No Child Left Behind Act,” marked an age of assessment and accountability. The Chemistry Department at Florida A&M University has taken on the challenge of addressing poor performance in General Chemistry I for majors. This course also served as a content course for students planning to teach science at the secondary level.

Approximately 50% of the students from Florida A&M University who eventually went on to work as teachers in the state of Florida in 2005, but were not on an accredited path, took General Chemistry I. Many of these students were part of a group who did not perform well in General Chemistry I. Therefore, the net impact on incoming high school students to the department is that they start General Chemistry I with an overall deficient background in Chemistry which has proven to have a significant deleterious effect on their progress in the course. To address this issue, the department has instated several instructional methods and enacted a placement exam, in hopes of improving the performance of students. Most of these methods resulted in no significant change in 110

TECHNICAL ABSTRACTS midterm exam results. However, use of the placement exam produced highly favorable results. This work will discuss in detail some of the actions taken by the Chemistry department, which have proven to be very instrumental in the overall success of students through the General Chemistry I course.

“Incorporation Of Critical Thinking Skills Into Research” 2:35 PM – 2:55 PM

Angela J. Winstead*, Alvin P. Kennedy

Morgan State University, Department of Chemistry, Baltimore, MD

Abstract The Undergraduate Research Development Program at Morgan is working to instill in students that learning is a continuous process in both the academic and research realm.

Challenges associated with this endeavor are: the transfer of information from the classroom to the research environment; and a mechanism to reinforce this process throughout the academic year. These challenges have been addressed by coupling interdisciplinary research projects with the development of critical thinking skills. Critical thinking (CT) skills are essential for a studentʹs intellectual growth and can be seamlessly incorporated in a variety of activities throughout the summer and academic year. The framework for the undergraduate research development program consists of three elements: critical thinking and literature, critical thinking and research, and critical thinking and peer review. Each element is based on the “The Thinker’s Guide Library” published by the Foundation for Critical Thinking. The research component consists of a research training strategy similar to the critical thinking framework to address the limited skill set associated with freshmen and sophomores.

“Inquiry‐Based Laboratories In Undergraduate Research Development 2:55 PM – Program” 3:15 PM Yongchao Zhang*, Angela J. Winstead Department of Chemistry, Morgan State University, Baltimore, MD Abstract The Undergraduate Research Development Program at Morgan is developing inquiry‐ based laboratories in its summer research program. The purpose is to integrate critical thinking skills into laboratory research. In an inquiry‐based laboratory setting, students are given a simple description of the goal of the project. They are divided into several groups and are engaged in a discussion of the nature of experimental design and analysis.

Each group comes up with two different experimental designs towards the goal, and 111

TECHNICAL ABSTRACTS proceeds with their experiments. The groups then report their results and openly discuss and evaluate each experimental design’s strength and weakness. They then return to their groups and refine their designs and finish the experiment. After the experiment, the CT module ʺPost Experiment Analysisʺ (Paul, 2003) is applied and laboratory reports are written. We are currently implementing one inquiry‐based experiment in General Chemistry Lab in an attempt to encourage students to take an active role in laboratories and to engage them in CT activities.

3:15 PM – 3:35 PM

“Enhancing The Science Curriculum Of K‐12 Students”

Nichole L. Powell*, Albert E. Russell, Barbara G. Rackley, Gregory Pritchett, and Pamela M. Leggett‐Robinson

Tuskegee University, Department of Chemistry, Tuskegee, AL

Abstract Using a variety of venues, we seek to enhance the science curriculum of K‐12 students within the Alabama black‐belt region. Our programs include outreach to K‐12 schools and research experiences for teachers and high school students. The primary aim of each program is to foster a lifelong appreciation of chemistry and its relevance to everyday life.

We present our experiences and lessons learnt.

Monday, PM

Technical Session 4

1:45 PM – 3:30 PM Room 411 Bioapplications in Physical Chemistry Session Chair Darlene Taylor Department of Chemistry, North Carolina Central University Presenters

1:45 PM – 2:15 Highlighted Speaker “Gold Alkanethiol Self‐Assembled Monolayers As Building Blocks PM For Site Directed Drug Delivery For Structural Biomedical Implants”

Carl E. Bonner, Jr., Chanel Smith, Rahul Buhre, Anil Mahapatro,

Center for Materials Research, Norfolk State University, 700 Park Avenue, Norfolk, VA

Abstract

112

TECHNICAL ABSTRACTS Structural implants such as stents, are used to assist to maintain the structural integrity of veins and arteries that have been weakened. Though these devices are made of surgical grade steel or other high quality metals, our immune systems often recognizes these materials as foreign bodies and attempts to coat them which creates a blockage. To address this issue, anti‐coagulants and anti‐inflammatory drugs are delivered to the stent site. However, the lack of a controlled release mechanism necessitates additional post implant administration, usually intravenously.

To enable a controlled release of anti‐inflammatory and anti‐coagulant drug at the site of the stent, a more biologically robust coating and delivery system is necessary. We have taken a multi‐layer approach to the design of this system, which includes an initial high density metal‐to‐organic coating that was first demonstrated with Au/alkanethiol self‐ assembled monolayers and extended to 316L Stainless steel alkane thiol and then the more commonly used Nickel/Titanium alloy, Nitinol. With this initial layer we have built up subsequent layers with control of the hydrophobicity and biochemical surfaces that can enable controlled release of drugs from the surface.

“Understanding Protein Diffusion Versus Biopolymer Volume 2:15 PM – Fraction In Live Escherichia coli” 2:30 PM Colin J. Ingram1, Ben P. Bratton1, Michael C. Konopka1, Roman V. Belousov1, Kem A. Winter1, Irina A. Shkel1, M Thomas Record, Jr.1,2, and James C. Weisshaar*1 1University of Wisconsin, Department of Chemistry, Madison, WI 2University of Wisconsin, Department of Biochemistry, Madison, WI

Abstract We have previously measured green fluorescent protein (GFP) diffusion in the cytoplasm of Escherichia coli grown in minimal media by fluorescence recovery after photobleaching (FRAP). Systematically increasing the mean biopolymer volume fraction <φ> by either increasing the growth osmolality (where cells adapt) or sudden osmotic upshift (plasmolysis) allows us to investigate the severity of possible crowding, binding, and confinement effects in vivo. While increasing <φ> by varying the growth osmolality causes a small decease in <D> (from 14.8 ± 3.4 to 6.1 ± 2.4 μm2‐s‐1), we find a factor of 70 decrease in <D> to 0.20 ± 0.16 μm2‐s‐1 over the same range of <φ> with plasmolysis. Crowding models, such as Scaled Particle Theory (SPT), alone are unable to account for the difference between the two methods. We are investigating alternative models that can explain the difference in <D> vs. <φ> using time‐resolved anisotropy and two‐color microscopy methods. One model we consider is that there are two‐domains of diffusion in the cell: 113

TECHNICAL ABSTRACTS slower local GFP diffusion within the nucleoid due to larger crowding/confinement effects and faster local GFP diffusion in the ribosomerich cell periphery due to ineffective crowding by the larger ribosomes. The effective D we measure is a composite of these two domains. According to this model, adapted cells will maintain the segregation of the two domains, while in plasmolyzed cells the periphery volume decreases and proteins diffuse more through the nucleoid, decreasing the effective D dramatically.

“Quantum Mechanical Prediction Of Fluorine NMR Chemical Shifts 2:30 PM – In Biologically Relevant Compounds” 2:45 PM

Duane Williams*1, Martin B. Peters1 and Kenneth M. Merz, Jr.1 1University of Florida, Department of Chemistry & Quantum Theory Project, Gainesville, FL

Abstract We have extended the semiempirical Modified Neglect of Diatomic Overlap (MNDO) methodology for qualitative description Nuclear Magnetic Resonance (NMR) chemical shifts with the addition of NMR‐specific parameters for the fluorine atom. Our approach can be employed using semiempirical (AM1/PM3) geometries with good accuracy and can be executed at a fraction of the cost of ab initio methods, providing an attractive option for the computational studies of 19F NMR for much larger systems. This parameterization was specifically geared towards qualitatively reproducing the chemical shifts of fluorine atoms in biologically relevant compounds and is applicable for fluorine atoms involved in carbon‐fluorine bonds. The new parameters yield results comparable to NMR calculations performed at the DFT (B3LYP) level using the 6‐31++G* basis set.

2:45 PM – 3:00 “Controlled Synthesis Of A Water‐Soluble Hyperbranched Polymer As A Transporter For Anticancer Drugs” PM Melody N. Gibson, and Darlene K. Taylor* North Carolina Central University, Department of Chemistry, Durham, NC Abstract Most anticancer drugs are taken up non‐specifically by all types of cells, resulting in serious side‐effects. Several polymeric platforms have demonstrated some degree of success, however, the ideal platform has yet to be employed. An integrated approach is needed to exploit and combine the very best features of the most successful therapeutic technologies. The objective of this research is to capitalize on the successes of dendritic materials (through a closer investigation of the related hyperbranched polyglycerols (HPG) platform) merged with block copolymer materials. This presentation will discuss 114

TECHNICAL ABSTRACTS preliminary results on the design of a hybrid system involving linkers and HPGs as a therapeutic platform for pH sensitive drug delivery of anticancer drugs. The HPG has been characterized using MALDI‐TOF (5220 g/mole), DEPT (degree of branching = 0.50), and 13C NMR (degree of polymerization = 34). Studies on a novel pH dependent linker and prodrug conjugate will also be presented.

“Preliminary Molecular Dynamic Simulations Of The Estrogen 3:00 PM – Receptor From Antagonist To Agonist” 3:20 PM

T. Dwight McGee1, Jesse Edwards1, Adrian E. Roitberg2

1Department of Chemistry, Florida A & M University, Tallahassee, FL 2Department of Chemistry and Quantum Theory Project, University of Florida, Gainesville, FL

Abstract Estrogen receptors are known as nuclear receptors. They exist in the cytoplasm of human cells and serves as a DNA binding transcription factor, which regulates gene expression.

However the estrogen receptor also has additional functions independent of DNA binding. The human estrogen receptor comes in two forms, alpha and beta. This work focuses on alpha form of the estrogen receptor. The ER is found in breast cancer cells, ovarian stroma cells, endometrium, and the hypothalamus. It has been suggested that exposure to DDE, a metabolite of DDT, and other pesticides causes conformational changes in the estrogen receptor. Before examining these factors exclusively, this work examines the protein unfolding from the antagonist form found in the 3ERT PDB crystal structure, which has the estrogen receptor, bound to the cancer drug 4‐hydroxytamoxifen.

The conformational change exposes the binding clef of the co‐peptide beside Helix 12 of the receptor forming the agonist conformation. Two key conformations in the loops at either end of the H12 produce the antagonist to agonist conformation. The results were generated a 42ns Molecular Dynamics simulation using AMBER FF99SB.

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Monday, PM Session Chair

3:45 PM – 4:15 PM

Technical Session 5

3:45 PM – 5:45 PM Room 410 Nanotechnology Applications I Kwame Owusu‐Adom Department of Chemical and Biomedical Engineering, University of Iowa

Presenters

Highlighted Speaker “Polymer/LC Dynamic Gratings”

Timothy J. Bunning

Air Force Research Lab, MLPJ, WPAFB, OH

Abstract Nano‐sized polymer‐dispersed liquid crystal (PDLC) systems (<100 nm diameter) have distinct advantages in a number of applications due to a minimization of light scattering and an increase in switching speed. The key to formation is the proper photochemistry which will restrict droplet growth and coalescence due to fast gelation of the growing polymer network. We present some examples of 0‐D, 1‐D, 2‐D, and 3‐D ordered systems.

Multidimensional ordering is done by holographic photopolymerization using two or more interfering laser beams. Using 2‐beam holography, simple switchable transmission and reflection diffraction gratings can be formed. More importantly, the diffractive properties of the system can be modulated in a gray‐scale mode using an applied electric field. We also report the recording of holographic polymer‐dispersed liquid crystal reflection gratings while applying a shear stress parallel to the film plane. High diffraction efficiency for light polarized in a direction parallel to the stress is obtained with nearly zero diffraction efficiency for the perpendicular polarization. Contrary to post‐recording stress‐induced polarization sensitization, the in situ process results in permanently polarized gratings.

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TECHNICAL ABSTRACTS 4:15 PM – 4:30 PM

“New Approaches For Size‐ And Shape‐Controlled Ruthenium Nanoparticles”

Ruel G. Freemantle and Sherine O. Obare

University of North Carolina – Charlotte, Department of Chemistry and the Nanoscale Science PhD Program, Charlotte, NC

Abstract

Catalytic metal nanoparticles with controlled size, shape, composition, and surface structure are important from both a fundamental and a technological viewpoint, due to their ability to offer high selectivity. However, there exists a major challenge in the ability to develop synthetic approaches that provide control over the size, shape, and dispersity of catalytic metal nanoparticles. The presentation will demonstrate a new one‐step synthetic procedure for monodisperse and well‐defined ruthenium nanoparticles. We have investigated the effects of various stabilizing ligands including thioethers and trialkylamines to control the growth and nucleation steps. Careful control of the reaction conditions, stabilizing ligands, and ratio of metal salt to stabilizing ligand led to well‐ defined monodisperse nanoparticles. Characterization by transmission electron microscopy, x‐ray diffraction, electrochemistry and energy dispersion x‐ray analysis confirmed the composition of the nanoparticles. Strategies for immobilization of these nanoparticles onto solid supports for potential catalytic applications will also be presented.

“Deactivation Of MS2‐Coliphage With Nanostructured Ta2O‐SiO2” 4:30 PM – 4:45 PM

William N. Harris III*1, Nicholas Ndiege2, Ramesh Chandrasekharan3, Sharifeh Mehrabi4, Mark A. Shannon3, Thanh H. (Helen) Nguyen5, Eric A. Mintz4

1Morehouse College, Department of Chemistry, Atlanta, GA 2 Department of Chemistry University of Illinois at Urbana‐Champaign, Urbana, Illinois 3 Department of Mechanical and Industrial Engineering University of Illinois at Urbana‐ Champaign, Urbana, Illinois 4 Clark Atlanta University, Department of Chemistry, Atlanta, GA 5 Department of Civil and Environmental Engineering University of Illinois at Urbana‐ Champaign, Urbana, Illinois

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TECHNICAL ABSTRACTS Abstract In recent years, there has been considerable interest in the use of nanostructure semiconducting metal oxides, such as TiO2 and NaTaO3, as photocatalysts for the destruction of contaminants in water. More recently it has been shown that mixing semiconducting metal oxides can improve the efficiency of photocatalysis because of: an increase in surface area, band gap shift to the visible light region of the spectrum, and the addition of a photoinert oxide that participates in charge transfer reactions and absorbs materials at its surface. Various ratios of nanostructured Ta2O5 on SiO2 particles were examined in terms effectiveness of these materials as UV‐photocatalyst for the deactivation of MS2‐coliphage (ATCC 15597‐B1) in various buffers over the pH range 2.3 to 4.3. These materials were prepared using a sol‐gel synthesis with a polyvinyl pyrollidone binder, 2‐methyoxyethanol and acetylacetone.

Break 4:45 PM – 4:50 PM

“Microwave Synthesis And AFM Characterizations Of 4:50 PM – Iron(III)‐Nickel Nanoparticles” 5:05 PM

Algernon T. Kelley, Nickolaus Flurry and Jayne C. Garno*

Department of Chemistry and the Center for Biomodular Multi‐Scale Systems Louisiana State University, Baton Rouge, LA

Abstract With widespread public concern for the disposal of chemicals or wastes it is a necessity and the modern trend for chemists to develop environmentally friendly or “Green chemistry” methods. Microwave systems promote the development of Green chemistry and are rapidly being incorporated into many industrial and academic research laboratories. The benefits of microwave ovens for sample preparation and synthesis include improved safety, speed, smaller reagent volumes and increased product yields in comparison to traditional methods. The primary goals of this project were to develop an accelerated method for producing high quality, monodisperse nanoparticles with targeted sizes using microwave heating. A hydrothermal process was used to synthesize magnetic nanoparticles in a microwave equipped with high pressure Teflon vessels. The microwave synthesis enables precise control of the temperature and pressure within a sealed container using a fiber optic thermocouple and a pressure transducer. Microwave synthesis produced nanoparticles ten‐fold faster than conventional radiative heating. We hypothesize that precise control of heating conditions in a microwave digestion vessel will lead to less polydispersity in the sizes of nanoparticles. Characterizations with atomic 118

TECHNICAL ABSTRACTS

5:05 PM – 5:20 PM

“Characterizing Functionalized Carbon Nanotubes Using Qualitative Analysis”

Tiffany N. Taylor1, Derrick R. Dean2, Pamela M. Leggett‐Robinson*1

1Tuskegee University, Department of Chemistry, Tuskegee, AL; 2Univeristy of Alabama‐Birmingham, Department of Materials Science and Engineering, Birmingham, AL

Abstract

The functionalization of carbon nanotubes (CNTs) serves as the key to unlocking their vast potential. CNTs have outstanding mechanical, electronic, and thermal properties, however, from a chemical perspective, pure carbon nanotubes are relatively insignificant due to the absence of functional groups. Functionalizing carbon nanotubes improves dispersion and solubility thereby expanding their potential to other areas such as biological applications.

Advances in the area of functionalization have been hindered due to the lack of a standard method for characterizing functionalized CNTs. Traditional characterization methods have provided only indirect evidence of the covalent attachment between carbon nanotubes and the entities of interest. In addition, results become more difficult to interpret with larger functional groups.

In this study, tradition methods and qualitative analysis were utilized to determine more accurate methods of characterizing functionalized carbon nanotubes.

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Monday, PM

Session Chair

3:40 PM – 4:20 PM

Technical Session 6

3:40 PM – 5:30 PM Room 411 Bioapplications in Materials Chemistry Gregory Tew Department of Polymer Science and Engineering, University of Massachusetts, Amherst

Presenters

Highlighted Speaker “Polyester And Polyester Urethane Based Biomaterials”

Valerie S. Ashby University of North Carolina at Chapel Hill, Department of Chemistry Chapel Hill, NC Abstract

A structure-property approach toward the synthesis of novel biomaterials was investigated. The new materials include polyester-based elastomers with similar mechanical properties to ligaments and vascular structures, as well as cyclic diacid-based amine-functionalized polymers. These materials possess a unique combination of features. Specifically, they are liquid at room temperature, readily crosslinked and processed, biocompatible, biodegradable and functionalized.

Amine-functionalized poly(butadiene) materials were also prepared and evaluated for their effectiveness as gene delivery vectors. The cytotoxicity, polyplex formation and transfection efficiency were determined and structure-property relationships established. More recently, these studies were extended to include polyurethane elastomers. The polyurethane synthesis incorporates hydroxy endcapped polyesters and amine-functionalized poly(butadiene)s to alter polymer properties. The design, synthesis, properties and processing of these materials will be discussed.

“Synthesis And Characterization Of Novel Nano‐ And Micro‐ 4:20 PM – Particles” 4:35 PM

Aaron Tesfai1, Bilal El‐Zahab1, David Bwambok1, Hadi M. Marwani1, Gabriela Ganea1, Gary A. Baker2, Sayo O. Fakayode3, Mark A. Lowry1, and Isiah M. Warner*1

1 Department of Chemistry, Louisiana State University, Baton Rouge, LA 2 Oak Ridge National Laboratory, Oak Ridge, TN 3 Department of Chemistry, Winston‐Salem State University, Winston‐Salem, NC Abstract

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TECHNICAL ABSTRACTS A simple and rapid oil‐ in‐ water emulsion preparation method was used to synthesize novel particles of nano and submicron dimensions. The average particle diameter was obtained using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The novelty of this work lies in the first demonstration of the synthesis of these new nanoparticles and the simplicity of the preparation to obtain tunable and desirable properties which render these novel particles ideal for a myriad of applications.

“Surface Functionalized Biopolymers For Phosphate Removal In 4:35 PM – Patients With End Stage Renal Disease (ESRD)” 4:50 PM

Anika A. Odukale*1, Christopher D. Batich 1Materials Science and Engineering, the University of Florida, Gainesville, FL Abstract In recent years, there has been a significant increase in the interest of surface functionalized materials as a means to efficiently produce novel biomaterials and therapeutic agents. Clinically, there is a growing appreciation for the need to avoid calcium based phosphate binders in patients with end stage renal disease (ESRD), as to prevent long term complications associated with elevated serum phosphate levels.

Current therapeutic agents used to alleviate this condition overwhelmingly involve the use of nonabsorbable synthetic polymers to bind excess phosphate. However, the price of these agents makes it an alternative not affordable to the greater general public. Thus, the need to develop a cost effective option exists. Polymers can be developed, that possess a potential for enhanced stability, lower cost, and selectivity that mimic natural binding phenomena, making them attractive materials. We described a technique for the synthesis of novel surface functionalized gelatin microparticles as oral phosphate binding agents.

Using a modified general emulsion polymerization schema, and genipin as a crosslinking agent, highly crosslinked, surface tailored, gelatin microspheres on the order of 10 – 50 μm are produced with high‐affinity phosphate binding functional groups attached. Serum phosphate uptake using the modified microspheres is evaluated in an in‐vitro milieu which simulates an in‐vivo gastric environment. Characterization of functionalized polymers is performed using UV‐VIS, light microscope, and scanning electron microscopy techniques. Potentially therapeutic polymers are thus realized with effective phosphate binding ability, thereby demonstrating feasibility of this novel low cost technology.

Break 4:50 PM – 4:55 PM

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TECHNICAL ABSTRACTS 4:55 PM – 5:05 PM

Poster Talk “An Examination Of Binding Energies In Biologically Relevant Systems Using Chemical Microscopy Of Protein Surfaces”

Chanel C. King, Dr. Carl Bonner*, and Dr. Katina Patrick

Center for Materials Research and Department of Chemistry, Norfolk State University, Norfolk, VA

Abstract Chemical reactions have associated binding energies. These binding energies tell how much energy is required to form a product. This research delves into the energetics of relevant biological systems, more specifically enzyme and substrate interactions.

The objectives of this research include (but are not limited to) mapping a particular surface using Chemical Force Microscopy, mapping the surface of an enzyme and substrate docking site using Bound Ligand Force Microscopy, studying the topology of surface using AFM and ultimately comparing the experimental results with the appropriate computer model.

Measuring attractive and repulsive forces by using various microscopy techniques maps the surface. Force curves are made to monitor those forces. A model is made using alkanethiol‐gold chemistry. Alkanethiol‐gold surface chemistry is a widely used technique that allows for different functional groups to be attached to a gold surface. Gold is important because it is biologically safe on the cellular level. Therefore it is a prime candidate for experimentation. Desired functional groups were transferred to the surface in an ordered manner. It was hypothesized that every group interacts with the surface with a certain amount of force. Once that value is known, you can experimentally find if that group present in your biological system. Additionally, the topology of the surface was determined. After, an enzymatic substrate will be allowed to react with an enzyme surface. The forces will be noted and compared with the model. The finding will then be compared with an appropriate computer model.

“Designing Macromolecules With Strong Similarities To Biology” 5:05 PM – 5:30 PM Gregory N. Tew Department of Polymer Science and Engineering, University of Massachusetts‐ Amherst, 120 Governors Drive, Amherst, MA, tew@mail.pse.umass.edu Abstract Many peptides, such as the Magainins and Defensins, are amphiphilic in nature and 122

TECHNICAL ABSTRACTS known to fold into specific conformations responsible for their antimicrobial membrane activity. Recently, facially amphiphilic peptides built from ‐amino acids have been shown to mimic both the structures as well as the biological function of natural antimicrobial peptides. The design of simple polymers and oligomers that mimic the complex structures and remarkable biological properties of proteins is an important endeavor and would provide attractive alternatives to the difficult synthesis of natural peptides. We have designed a series of facially amphiphilic molecules that capture the essential physical and biological properties of antimicrobial peptides, but are easy to prepare from inexpensive monomers. They have potent activity (single micromolar).

They are active against a broad spectrum of bacteria including gram‐positive and gram‐ negative as well as antibiotic resistant strains. Recent, data provides new insight into their physiochemical activity including the formation of 3 nm pores that are lipid composition dependent

“Electrionic Conductive Polymers With Biospecific Binding 5:15 PM – Capacities: New Materials For Nanoscale Biosensors” 5:30 PM

1 Reuven Darkeyah*, 1 Sannigrahi Biswajit, 1 Khan Ishrat*, 2 Sil Dwaipayan, 2 Baird Barbara*

1Department of Chemistry, Clark Atlanta University, Atlanta GA 2Department of Chemistry and Chemical Biology, Cornell University , Ithaca, NY

Abstract A series of DNP (2,4‐dinitrophenyl)functionalized polypyrrole polymers that are specific to antibodies and immune receptors on cell have been synthesized and characterized (See Figure). This is a terpolymer composed of three monomers; monomer 1 (M1, pyrrole), macromonomer 2 (M2, pyrrole with pendant ethylene glycol) and macromonomer 3 (M3, pyrrole with pendant DNP). These polymers are expected to be useful for controlling receptor binding and cell activation, and with eventual application in biosensors.

Conductivity measurement indicate that the terpolymers are conductive, without adding external doping agents conductivity values of 5 x 10‐6 S cm‐1 (at 25 oC) were obtained.

Binding studies with anti‐DNP IgE studies are promising, fraction of binding sites occupied vs. concentration indicates specific and efficient binding at nanomolar concentration. Therefore, DNP functionalized polypyrrole are excellent materials for preparing nanowires in biosensors for detecting biomarkers. We have also determined that these polymers are biocompatible. Nanowires are currently being fabricated using the functionalized conductive polymers.

In addition to synthesis and characterization, the thermal properties of the functional 123

TECHNICAL ABSTRACTS polymers will be discussed with regards to the fabrication of nanowires for biosensing applications.

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Tuesday, AM

Technical Session 7

9:45 AM – 11:45 AM Room 411 Biofuels: Opportunities, Challenges, and Technology Development Session Chair Emmanuel Dada FMC Corporation, Princeton, NJ Presenters

9:45 AM – 10:15 Highlighted Speaker “Biofuels: Opportunities, Challenges and Technology Development” AM

Foster A Agblevor

Department of Biological Systems Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA fagblevo@vt.edu

Abstract The need for sustainable and environmentally friendly energy production calls for a paradigm shift in the traditional approach to research, technology development, and the production of raw materials. Instead of petroleum‐based economy we are looking at biomass as the engine of the future. The biobased economy is the sustainable economic development centered on renewable bioresources such as wood, grass, micro‐algae, agro‐ industrial wastes, and many others. We foresee the development of biorefineries instead of petroleum refineries. Besides corn‐ and sugarcane‐ethanol production what are the other alternatives? Are corn and sugar cane based‐ethanol production sustainable? In this presentation, I will discuss the production of biofuels and the production of co‐products and by‐products such as biodegradable plastics, protein adhesives, phenolic resins, chemicals, and other materials, which are totally based on biomass feedstocks. The role of biotechnology, thermochemical and biochemical conversions processes in the production of these products as well as the barriers that have to be overcome to translate some of the 124

TECHNICAL ABSTRACTS laboratory research into consumer products will be discussed.

“The Potential Impact Of Invasive Aquatic Plants On The Sustainable 10:15 AM – Production Of Cellulosic Ethanol” 10:30 AM

Lealon L. Martin*1

1Rensselaer Polytechnic Institute, Howard P. Iserman Department of Chemical and Biological Engineering, Troy, NY

Abstract We are currently in the midst of a timely opportunity to develop sustainable biofuels technology given the uncertainty over the availability and cost of fossil fuels in a period of growing energy demand in the U.S., Asia and other parts of the world. In addition, this opportunity is timely because of the growing concerns that CO2 emissions are driving climate change and generating uncertainty over the sustainable future of humanity.

However, we are entering this period of uncertainty with a vast storehouse of scientific discoveries and engineering innovations that give us reason to hope that human development can be sustained. Advances in system engineering and the advent of systems biology and systems ecology are creating a broad spectrum of opportunities for identifying and manipulating microbial and plant systems to produce biofuels and industrial chemicals. The challenge is to harness these opportunities in a systematic and sustainable manner to ʺre‐engineerʺ our energy and material world. What is needed to address this challenge is a strong basic and applied biological, ecological, and engineering research capacity that is well integrated to capture systems complexity at multiple levels. To this end we propose a ʺmultiplex systems approachʺ to developing the paradigm of ʺagriculture as a provider of energy,ʺ and for making important breakthroughs in sustainable technology that will catalyze the development of a viable domestic Bioenergy industry.

Here we explore the utilization of Eichhornia crassipes , commonly known as water hyacinth, as a competitive source of biomass for conversion to fuel. Ecologically, E. crassipes is the most undesirable of a class of noxious and invasive aquatic vegetation.

Water hyacinth grows rapidly on the surface of waterways, forming a dense mat which depletes the surrounding environment of essential nutrients. These properties, rarely encountered in other plant systems, are features of an ideal feedstock for renewable biomass. The high characteristic water content limits the range over which the material can be transported; however it also makes E. crassipes a natural substrate for rapid microbial metabolism that can be employed as a potentially effective biological pretreatment technology. It was shown through a life cycle analysis incorporating novel techniques that water hyacinth is a competitive feedstock with the potential to be produced at less 125

TECHNICAL ABSTRACTS than 30$ per ton of dry mass. This is a considerable economic benefit, since biomass is currently produced in the range of $50 per dry ton.

“Use Of Biomass/Coal Co‐Gasification Ash/Chars As Soil 10:30 AM – Amendments” 10:45 AM

Murphy J Keller, III*, Harry M. Edenborn, Ed Klunder and Dave Luebke U.S. Department of Energy, National Energy Technology Laboratory, (NETL) Pittsburgh, PA

Abstract With the growing interest of reducing CO2 emissions and mitigating potential climate effects, it is important to address energy requirements via the utilization of renewable resources. Coal remains a viable fossil energy resource and will be necessary to supplement this approach. One of many challenges that is facing us is to develop novel techniques that will allow the integration of coal and renewable resources to assist in meeting America’s needs in the most cost effective and energy efficient means feasible. Co‐ gasification of fossil and bio materials is a potential way to perform the proposed integration. This process may be accomplished either by injection into a single high temperature gasification system resulting in the production of fuel gas and a mixed ash or by a two stage procedure whereby a low temperature biomass gasification stage feeds a higher temperature coal gasification stage producing a biomass‐only, high‐carbon char.

Biomass char employed as a soil amendment remains in the soil for centuries, improving crop yields for fuel or food. Recent preliminary field trials with selected food crops have already shown twice to three times higher yields per acre compared to base conditions.

One characteristic of char is its high porosity, which promotes high water retention and air accessibility in soil. Its high surface area and absorptive capacity sequesters fertilizer and pesticides, resulting in slowed release to the environment. Recently rediscovered areas of fertile soils in the Amazon basin contain charcoal as their main ingredient. Initial estimates project that carbon sequestration in char‐amended soil is three to five times higher per acre than is currently achieved by conventional terrestrial sequestration.

Presently, there is an increasing demand to bridge the gap that seemingly exists between government, private industry and academia. Accordingly, NETL is interested in forming partnerships with fellow government agencies that have similar ideas/plans.

Collaborations with interested colleges/universities will enhance our ability to promote existing programmatic needs such as fellowships, internships, funding opportunities/resources, etc. Finally, depending on the methodology of approach, industry could perhaps gain the ability to more efficiently get valuable biomass to facilities for conversion into energy or fuels.

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TECHNICAL ABSTRACTS 10:45 AM – 10:50 AM

10:50 AM – 11:05 AM

Break

“Synthesis Of Biodiesel Via Ultrasound‐Enhanced Homogeneous And Solid Acid Catalyzed Processes – A Critical Review” Yusuf G. Adewuyi

North Carolina Agricultural & Technical State University, Department of Chemical Engineering, Greensboro, NC Abstract Biodiesel is an oxygenated diesel fuel consisting of mono alkyl esters of long chain fatty acids derived from renewable lipid feedstocks such as vegetable oils or animal fats, made up of triglycerides (TGs) and free fatty acids (FFAs) and is produced via the chemical process of transesterification. Biodiesel is not only biodegradable but it is also free of sulfur and aromatics. Biodiesel is produced by reacting the lipid feedstocks with an alcohol, such as methanol or ethanol in the presence of a catalyst (sodium or potassium hydroxide, or sodium methoxide) to yield methyl esters (biodiesel) and byproduct glycerin used to make soaps and cosmetics. This reaction does not tolerate the presence of water or fatty acids and the use of acids such as H2SO4, H3PO4, and HCl pose environmental and corrosion problems. The use of solid acids such as zeolites or zirconium sulfate would eliminate the need to use liquid acids or bases, the subsequent corrosion of process equipment and soap formation, and would make catalyst separation from products trivial and permit the use of continuous rather than batch processing. Cavitation is the formation, growth and implosive collapse of gas‐ or vapor‐filled microbubbles and can be induced acoustically or hydrodynamically in a body of liquid. The collapse of these bubbles leads to local transient high temperatures ( 5000 K) and pressures ( 1000 atm), resulting in the generation of highly reactive species including hydroxyl ( OH), hydrogen (H ) and hydroperoxyl (HO2 ) radicals, and hydrogen peroxide. Cavitation effects also increase the mass transfer and accelerates the reaction rate and yield of esters. However, little fundamental research has been carried out to date on the production of biodiesel via ultrasound enhanced homogeneous and heterogenous catalysis of esterificationa nd transesterification. This talk will present extensive review of the literature and future research directions.

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TECHNICAL ABSTRACTS 11:05 AM – 11:20 AM

“Palm Oil‐Based Biodiesel: A High Oil Content Source Of Alternative Fuel” Emmanuel A. Dada FMC Corporation , P. O. Box 8, Princeton, NJ Abstract

There are many available sources of oilseeds including palm oil, soybean, cotton seed, sunflower seed, rapeseed, castor bean, peanut, sesame seed, and macadamia nut for making biodiesel. Palm oil, widely grown in Africa, Brazil, and Southeast Asia, is second to soybeans in the global oil production from oilseeds. It has up to 12 times more oil content than many of the other oilseeds including soybeans. Palm‐based biodiesel, without the addition of chemical stabilizers, meet military biodiesel specifications and the stability requirements of the major oil companies. Also, palm‐based biodiesel is a clean‐burning fuel and has the highest positive energy balance of all biofuels, generating six times more energy than it takes to make it compare with petroleum diesel that generates 20% more energy than it takes to make it. In general, biodiesels as alternative fuels are biodegradable, non‐toxic, and free of sulfur and aromatics.

President Bush in his January 2007 State of the Union Address set a goal for the nation to displace 20% of the fossil fuels with renewable fuels by 2017 an equivalent of producing 35 billion gal/year of renewable fuels. With crude oil selling over $80/barrel in the global market‐place, the search for cheaper alternative fuels has become more important. The capacity growth of biodiesel in the US that has more than quadrupled in recent years will be discussed. The Brazil initiatives that have made it the world leader in bioethanol will also be discussed.

11:20 AM – 11:35 AM

“Kinetics Of Cellulose Hydrolysis In Supercritical And Subcritical Water”

Kazeem B. Olanrewaju, Taiying Zhang, and Gary A. Aurand* The University of Iowa, Department of Chemical and Biochemical Engineering,Iowa City, IA

Abstract More efficient conversion technologies are needed to utilize cellulosic biomass for the production of fuels and chemicals. The hydrolysis of cellulose via enzymatic methods is slow and requires expensive enzymes. In contrast, cellulose hydrolysis in supercritical water proceeds very rapidly without the need for a catalyst, but results in monosaccharide degradation products due to the high temperature. To obtain high monosaccharide yield, the rate of cellulose hydrolysis must be high relative to the rate of subsequent glucose 128

TECHNICAL ABSTRACTS degradation. However, treatment at lower, subcritical temperatures is ineffective because of cellulose insolubility. Results of fundamental reaction kinetics experiments have led to a strategy comprising sequential supercritical and subcritical water treatments to increase the yield of monosaccharide from cellulose while maintaining very high reaction rates. In addition, a comprehensive kinetic model describing the process of cellulose hydrolysis in hydrothermal systems is under continued development.

“Progress In Modeling Chemical Looping Combustion Systems” 11:35 AM – 11:50 AM

Isaac K. Gamwo1 and Jonghwun Jung2

1U.S. Department of Energy, National Energy Technology Laboratory, Pittsburgh, PA 2Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL

Abstract Energy companies have been investing in alternatives to fossil fuels, including renewable such as solar power, but believe that these are unlikely to replace fossil fuels in the short and medium term if the world’s ever‐increasing energy requirements are to be met at an acceptable cost. Fossil fuels (coal, oil, and natural gas) will still be in demand for the foreseeable future as the demand for energy is expected to grow worldwide. However, fossil fuel combustion for power generation increases atmospheric CO2 concentration.

Hence, it is important to develop new technologies during this decade that will reduce the impact of continued fossil energy use while cleaner energy sources are being developed.

Tuesday, AM

Technical Session 8

9:45 AM – 11:45 AM Franklin 1 Nanotechnology Applications II Session Chair Kwame Owusu‐Adom Department of Chemical and Biomedical Engineering, University of Iowa Presenters

9:45 AM – 10:05 “Investigation Of The Vibrational Response Of Individual Nanoparticles Using AFM With Magnetic Sample Modulation” AM

Wilson K. Serem,1 Alessandro Varotto,2 Glenys Castro,1 C. Michael. Drain2 and Jayne C. Garno1* 129

TECHNICAL ABSTRACTS

1Department of Chemistry and The Center for BioModular Multi‐Scale Systems Louisiana State University, Baton Rouge, LA 2 The Graduate Center & Hunter College of The City University of New York, Department of Chemistry & Biochemistry, 695 Park Avenue, New York, NY and The Rockefeller University, 1230 York Avenue, New York, NY

Abstract

We are developing new AFM imaging mode, magnetic sample modulation (MSM) to selectively characterize the vibrational response of magnetic particles. A periodic oscillating magnetic field is applied to the sample stage to induce physical movement of ferromagnetic materials. The movement can be sensitively detected and mapped using a soft uncoated AFM probe while imaging in contact mode. Magnetic sample modulation provides a means to distinguish the magnetic response for samples as small as 5 nm. A key strategy for developing the new AFM imaging mode is to use designed nanopatterned arrays of magnetic nanoparticles to evaluate the sensitivity and resolution of MSM. We have developed a practical benchtop approach for particle lithography to produce designed arrangements of metal nanoparticles with tunable dimensions and periodicity.

Particle lithography is a high throughput fabrication process used to organize nanomaterials on surfaces. “Two particle” lithography method is being developed to organize metal nanoparticles and other materials on surfaces. Combining lithography and AFM characterizations is a practical approach for analysis of surface properties at the nanoscale.

10:05 AM – 10:25 AM

“Aerogel Synthesis”

Nellone E. Reid*1, Jennifer Jolly

1Hampton University, School of Engineering and Technology, Hampton, VA

Abstract Aerogels are extremely porous, fragile materials that exhibit new and exciting chemical and mechanical properties. Many aerogels resemble frozen smoke, and feel and act much like a sponge. The nanosize pores formed when making aerogels have very large surface area within the material as well as low mean free path of air. These properties are essential for functions involving reactivity and conductivity, respectively. We can control these properties by regulating precursors and synthesis conditions. For example, density has a high correlation to the surface area which can be controlled by varying the basicity of 130

TECHNICAL ABSTRACTS the solution during synthesis. Aerogels also serve as incredible energy absorbers. This is expected because of their ability to be compressed, which is due to it being a solid material of low density. Once again, density can be controlled by manipulating the pH of the material during preparation.

In our lab, we are synthesizing silica aerogels. These aerogels are first prepared by preparing a solution comprised of varying precursors and a catalyst. After the solution is mixed homogenously, it is allowed to sit until a gel is formed. Currently we are super critically drying sol gels using carbon dioxide. This allows us to replace the alcohol in the sol‐gel with carbon dioxide under high pressure and moderate temperatures without cracking the material. Many structures become fractured due to the capillary action liquid within the pore walls, when dried by air.

The major process variables are the pH level of the sol‐gel, temperature, aging time, alcohol to alkoxide ratio and water to alkoxide ratio. The focus of our research is to determine the effects of these variables on the properties of aerogels using an experimental plan based on a 2‐level factorial design. Some properties will include UV‐Vis behaviors, BET surface area, mechanical strength and the appearance of the gel. The final stage of our experimental program will be to associate these properties to real‐life functions, such as catalytic activity and thermal conductivity.

10:25 AM – Highlighted Speaker “Functional Thin Film Polymer Surfaces” 11:05 AM

Damla Koylu, Janet A. Maegerlein and Kenneth R. Carter Polymer Science and Engineering Department, University of Massachusetts – Amherst Amherst, Massachusetts

Abstract We embed chemical functionality into crosslinked network polymers. This functionality can be accessed in subsequent reactions, allowing for the creation of surfaces with controlled size and chemistry. We have demonstrated that this methodology works from flat films, patterned nanostructures and particles, providing a powerful, robust, new technique for functionalizing surfaces. We have been exploring polymer interfaces of the polymer networks and subsequent modification of the network surface functionality. We add a functional comonomer to our curable polymer resin and after molding a fraction of this incorporated functionality is present at the surface of the polymer and available for subsequent reactions. This concept of embedded functionality has been exploited in a number of ways. For example, we have used these surfaces for selective the metallization and we have been exploiting the surface functionality to accommodate the attachment of semiconducting polymers and bioactive materials. The synthesis, characterization and use 131

TECHNICAL ABSTRACTS of these new materials and related techniques are discussed.

“Atomistic Simulation Of Tensile Behavior Of Graphene 11:05 AM – Polypropylene Nanocomposites” 11:25 AM

Rozlyn N. Chambliss and Melissa S. Reeves*

Tuskegee University, Department of Chemistry, Tuskegee, AL

Abstract Carbon‐based nanomaterials such as carbon nanofiber (CNF), single‐walled carbon nanotubes (SWNT), and multi‐walled carbon‐nanotubes (MWNT) have been used as fillers in nanocomposites due to their potential for improving tensile strength and modulus. In this research, graphene and modified graphene were used as fillers in polypropylene (PP) to simulate nanocomposite systems. Four systems were studied: neat PP, PP with a small graphene sheet, PP with a graphene sheet with a covalent modifier attached at the center, and PP with a graphene sheet with a covalent modifier on a “corner” atom. The filled systems correspond to an 8.5% w/w loading of the nanoparticle. The purpose of this work was to examine by atomistic simulation the effect graphene and a modifier has on the nanocomposites’ tensile behavior. All calculations were performed with Accelrys’ Material Studio 3.2 using the COMPASS forcefield. Static mechanical properties measured by means of molecular mechanics did not show differences among the four systems; however this method assumes isotropic behavior. Two methods of stress strain curve measurements were examined: either application of a uniaxial strain or application of a uniaxial stress. The applied strain method resulted in a Young’s moduli of 1.2GPa for neat PP, which corresponds with the known value for PP. The second method, the application of a uniaxial stress during molecular dynamics, mimics experimental methods, albeit at a very high strain rate. These applied stress simulations produced stress‐strain curves with a trend in improvement of the tensile modulus over the neat PP (0.47 0.09 GPa), with a distinctly larger modulus for the end‐modified graphene/PP system (0.75 0.17 GPa). The moduli from these stress‐strain curve simulations were relatively low compared to literature values for PP and to the strain‐applied MD. Two simulations of unmodified graphene/PP systems underwent delamination events with the applied stress while none of the other systems showed similar behavior. This implies that modified graphene nanocomposites will have improved strength over the unmodified systems.

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TECHNICAL ABSTRACTS 11:25 AM – 11:45 AM

“Photopolymerization Kinetics Of Binary Thiol‐acrylate Nanocomposites”

Kwame Owusu‐Adom and C. Allan Guymon*

Department of Chemical & Biochemical Engineering, University of Iowa, Iowa City, IA Abstract Development of clay‐polymer nanocomposite materials is of research interest because of certain unique properties attainable from incorporating small concentrations of clay into the polymer host. These unique properties have been attributed to the nanoscale dimensions of the clay particles. Clay surfaces are typically modified with quaternary ammonium surfactants to enhance dispersion in the polymer hosts. Because of the ability to modify the surface, specific properties could potentially be designed into the clay nanocomposite material. In this project, the effects of clay nanoparticles modified with reactive functionalities on the polymerization kinetics of uv‐cured nanocomposites are investigated. Real time infrared spectroscopy (RTIR) and small angle x‐ray scattering (SAXS) were used to investigate the dispersion and photopolymerization kinetic behavior of thiol‐acrylate compositions. The effect of surfactant chain length and functional group on polymerization kinetics was also investigated via RTIR studies. Addition of polymerizable organoclay leads to higher photopolymerization rates compared to the unfilled polymer. Within the polymerizable organoclays, polymerization rates increase with longer surfactant chain length. In addition, thiol conversion increases significantly with increasing polymerizable organoclay concentration. By increasing photo‐ polymerization rates with added organoclays, this research opens new ways for developing nanocomposites while taking advantage of the speed of the photopoly‐ merization process.

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Tuesday, AM Session Chair

9:45 AM – 10:05 AM

Technical Session 9

9:45 AM – 11:50 AM Room 412 Physical Chemistry Shawn Abernathy Department of Chemistry, Howard University Presenters

“High‐Accuracy Ab Initio Studies Of Tetrasulfur Energetics”

John A.W. Harkless*1 and Joseph S. Francisco2

1Department of Chemistry, Howard University, Washington, DC 2Department of Chemistry and Department of Earth & Atmospheric Sciences, Purdue University, West Lafayette, IN

Abstract We apply the quantum Monte Carlo method to the problem of energetics of S4 conformers and dissociation. The results presented here estimate the energy gap between the C2V and D4h conformers of S4, an important species in interstellar chemistry using variational Monte Carlo (VMC) and diffusion Monte Carlo (DMC). In addition to the energy gap of the conformers, we also provide VMC and DMC estimates of atomization and bond energies of S4, as well as selected excited states. The overall effectiveness and accuracy of the method is compared against other available theory and experiment.

“Infrared Optical Absorption of Divalent Lead Pb(II) Complexes from 10:05 AM – First Principles” 10:20 AM

Heng Li, Vladimir I. Gavrilenko Center for Materials Research, Norfolk State University, 700 Park Avenue, Norfolk, VA Abstract During the past several decades enormous effort has been dedicated to experimental and theoretical studies of metal‐radical organic complexes. These systems exist in the active form of metalloprotains and have unusual bonding patterns, structures, optical and magnetic properties. Theoretical modeling of optical absorption is important component of detailed understanding of fundamental properties of the materials. In this work optical absorption spectra are calculated within random phase approximation (independent particles picture). Equilibrium geometries and electron energy structure of divalent lead 134

TECHNICAL ABSTRACTS Pb(II) complexes with ortho‐semiquinone radicals have been calculated by generalized gradient approximation method (GGA) within density functional theory (DFT) using ab initio pseudopotentials. Predicted features of optical absorption spectra in visible and infrared (IR) regions are attributed to electron excitations related to specific atomic configurations of the metal‐radical complexes. Atom and orbital resolved Projected Density Of States (PDOS) spectra are used for detailed understanding of the predicted IR optical spectra. Comparative analysis of PDOS and IR spectra indicate substantial effects of CH groups on the IR absorption.

“Nonlinear Optical Studies Of Specific Solvation Across Liquid 10:20 AM – Interfaces” 10:35 AM

A. Renee Siler*, Michael R. Brindza, and Robert A. Walker University of Maryland, Department of Chemistry and Biochemistry, College Park, MD Abstract Solution surfaces represent boundaries with properties that are different from the properties of the bulk solution. Surfaces necessarily change the way solvents solvate solutes because of inherent chemical asymmetry. Consequently, solute structure, conformation and reactivity at surfaces can differ significantly from bulk solution limits.

The asymmetry of surfaces also gives rise to the restrictions governing second order nonlinear optical techniques. These restrictions allow solute properties at the surfaces to be probed with nonlinear optical techniques in the absence of contributions from solutes in bulk solution. In this research, second harmonic generation (SHG) spectroscopy will be used to explore specific solvation forces at the liquid/solid and liquid/liquid interfaces.

Specific solvation refers to solute interactions with the surroundings that are both localized and directional. These interactions include but are not limited to hydrogen bonding. (In contrast, solvent polarity is a nonspecific solvation force and reflects solute‐ solvent interactions that are averaged over the entire solute cavity.) Our experiments use SHG to determine how specific solvation forces change across weakly and strongly associating liquid/solid and liquid/liquid interfaces. Of particular interest is how specific solvation at these surfaces differs from bulk solution limits and how specific solvation depends on solvent structure.

Our studies require the use of novel solvatochromic surfactants – molecular rulers – consisting of a hydrophobic solute sensitive to specific solvation forces connected to a charged headgroup by means of a variable length, alkyl spacer. The solute preferentially solvates in the organic phase, while the headgroup remains solvated in the aqueous phase (or bound to polar solid surfaces). Opportunities for hydrogen bonding at different 135

TECHNICAL ABSTRACTS distances relative to the interface are probed by different length surfactants. Previous studies using polarity‐sensitive surfactants showed that strongly associating interfaces create heterogeneous environments that can not be described by bulk properties of either adjacent phase. A primary goal of our research will explore whether or not these findings also apply to specific solvation forces.

Break 10:35 AM – 10:40 AM

“Electron Transfer Between Size Quantized Cdse And TiO2 Using 10:40 AM – Bifunctional Linkers In Reversed Micelles” 10:55 AM

Clifton T. Harris University of Notre Dame, Radiation Laboratory, Notre Dame, IN Abstract Amino acids (NH2‐R‐COOH) were used as bifunctional linkers to first enhance, and then quench CdSe emission via interparticle electron transfer to TiO2 in reverse micelles.

Particle sizes of CdSe and TiO2 were controlled by varying the water‐to‐surfactant molar ratio. Electron transfer is confirmed using Methyl Viologen (MV2+) as an indicator. The formation of MV+ under visible light excitation indicates that electrons generated at the CdSe particle are transferred across the micelle to the MV2+. The role of TiO2 in the formation of MV+ is investigated. Efficiency of electron transfer is also studies across several variables including relative particle sizes, length of R group, as well as amino acid and TiO2 concentrations.

10:55 AM – 11:10 AM

“Interfacial And Thermodynamic Phenomena Related To A Novel Liquid/Liquid Extraction Process For Solvents With A Small Density Difference”

Nicole James, Filomena Califano*

Chemistry and Physics Department, St. Francis College, Brooklyn Heights, NY Abstract Phase transition extraction, based on spinodal decomposition of partially miscible solvents has become an important tool in biotechnology. It has, however, one problem especially for separating proteins when the density difference between two phases is small; the separation is very slow and difficult because a centrifuge is required in multistage 136

TECHNICAL ABSTRACTS columns. In phase separations involving proteins, both phases have to be water‐rich to prevent denaturation. This results in density differences which are very small making multistage separation very difficult and often, impractical. Recently, when we were studying the spinodal decomposition of a hexadecane‐acetone mixture, which has a very low‐density difference between phases, we discovered that within a narrow range of conditions, large‐scale rapid flows, which are independent of gravity, lead to fast phase separation. We determined that such flows also occur in water‐rich solvent systems under feasible conditions, and an efficient extraction of large molecules can accompany these flows. We developed much more efficient multistage extraction and separation processes for proteins and similar compounds. This development can also become the basis of an extraction process in a microgravity environment.

“An AB Initio Study Of The Electronic Excited States, N2 And O2, Using Quantum Monte Carlo Methods”

Floyd A. Fayton Jr*, and John A.W. Harkless

Department of Chemistry, Howard University, 525 College St., NW, Washington, DC

Abstract Quantum Monte Carlo (QMC) refers to a class of ab initio methods that use a stochastic simulation to solve the many‐body Schrödinger equation. QMC differs from post‐Hartree Fock methods in that it includes electron correlation explicitly. Diffusion Monte Carlo (DMC) and Variational Monte Carlo (VMC) are applied to elucidate the thermodynamic and electronic properties of reactions of that involve nitrogen and oxygen.

In order to reach that goal, excited states of the binary compounds for nitrogen and oxygen were estimated in order to illustrate the ability to accurately describe the range of reactions that may occur. Selected excited states of the constituent elements were calculated in order to show the accuracy of various electronic structure techniques. These techniques include DMC, VMC, CASSCF and CISD. The basis set used was cc‐pVTZ and all calculated values were compared against experiment.

“The Time Dependence Of The Changes In The Emission Spectrum 11:25 AM – Of Comet 9P/Temple 1 After Deep Impact” 11:45 AM

William M. Jackson*, XueLiang Yang1, and Anita L. Cochran2

11:10 a.m – 11:25 AM

Department of Chemistry, University of California, 1 Shields Avenue, Davis, CA Department of Astronomy and McDonald Observatory, University of Texas at Austin, C‐ 1400, Austin, TX

1 2

137

TECHNICAL ABSTRACTS Abstract

The time dependence of the changes in the emission spectra of Comet 9P/Temple 1 after Deep Impact are derived and discussed. This was a unique event because it gave astronomers the opportunity to follow the time history of the formation and decay of O(1S), OH, CN, C2, C3, NH, and NH2. Different kinetic models are used with known rate constants to fit the observed data. In the case OH the known rate constants for the photodissociation of H2O and OH provide a reasonable fit to the observed data. In most cases however a simple kinetic model cannot be used to fit the observed data even when the rate constants are varied in the model. In these cases a more complicated model that incorporates a second chemical mechanism, which produces the radical 2700 s after impact is required to fit the observations. The rate constants that are used in the models are compared with previous rate constants that have been proposed for the production and decay of these radical species and where there are discrepancies we discuss how they could arise.

Acknowledgements: We thank Dr. Fred Chaffee for making Director’s Discretionary time available pre‐impact. Our thanks to Dr. Hien Tran for obtaining the observations of 30 May and 4 July and for help on 5 and 6 July. This work was funded by NASA Grant NNG04G162G (A.L.C.), NASA Grant NNG06A67G (W.M.J.), NSF Grant CHE‐0503765 (W.M.J.) and by support from the University of Maryland through a subcontract 2667702 (K.J.M.), which was awarded under prime contract NASW‐00004 from NASA.

11:45 AM – Poster Talk “Physical Characterization Of Spectroscopic Methods: Mass 11:50 AM Spectroscopy”

Steven M. Cannon Chemistry Department , University of Illinois at Chicago, Chicago, Illinois Abstract Mass spectroscopy characteristics have raised it to an outstanding position among analytical methods. It has unequal sensitivity and detection limits and the diversity of its applications among atomic physics, reaction physics, reaction kinetics ,and all forms of chemical analysis especially biomedicine and ion‐molecular reactions. There are four components to the mass spectrometer: a device to introduce the compound that is analyzed, the gas chromatograph, a source to produce ions from the sample, one or several analyzers, a detector , and a computer. Also, I would like to investigate NMR spectroscopy. As you know , molecules are inconviently too small to be observed and studied directly. Nuclear magnetic moments are equally sensitive to their surroundings.

138

TECHNICAL ABSTRACTS Electron ionization leads to fragmentation of the molecular ion. Chemical ionization and proton transfer are other subjects of interest. Ion‐molecule collisions are induced in a definite part of the source.

Thermodynamics is commonly thought of as that subject which treats the transformation of energy and the accompanying changes in the states of matter. The laws of macroscopic thermodynamics clearly must arise out of many atoms and other particles. I would like to study the fundamental equations of states. Linear Transport Relations and kinetic description of dilute of gases are important. In material science, I would like to develop materials for the aging space shuttle.

Tuesday, PM

Session Chair

1:45 PM – 2:05 PM

Technical Session 10

1:45 PM – 3:30 PM Room 412 Graduate Students Sci‐Mix Symposium Marlon Walker NIST, Gaithersburg, Maryland Presenters

Dow Chemical Company Fellowship Awardee “Synthesis and Processing Of Silver Nanoparticles Through The Use Of CO2‐Expanded Liquids”

Gregory Von White II*1, Christopher L. Kitchens1

1Clemson University, Department of Chemical and Biomolecular Engineering Clemson, SC Abstract As technology advances in the field of nanotechnology, a greater understanding of the function of both size and shape is required. Metallic nanoparticles provide promise in this field because of their distinctive properties. These properties vary from bulk metals and can be tailored via their size, shape, and surface chemistries. Stabilizing ligands play a major role in the synthesis of metallic nanoparticles and allow for their dispersibility in various solvents, both aqueous and organic. By manipulating the surface chemistries of the nanoparticles through synthesis or ligand exchange, further studies and processing can be done. This presentation details some new techniques in silver nanoparticle synthesis and processing, including the separation of nanorods from spheres using CO2 expanded solvents. Ligand exchange techniques will also be covered, allowing for the dispersibility of nanoparticles synthesized in an aqueous media for redispersion in an organic phase.

UV‐VIS data and TEM imaging were used to characterize the resulting size and shape distributions of the nanoparticles.

139

TECHNICAL ABSTRACTS

2:05 PM – 2:25 PM

Eastman Kodak Dr. Theophilus Sorrell Fellowship Awardee “The Influence Of Gestation And Lactation Stage On The Peptide Profile Of Human Milk”

Kirsten Jeffries‐Grant*1, Randolph L. Rill2, Doris Terry2, Jeremiah Tipton3

1The Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 2The College of Medicine, Florida State University, Tallahassee, FL 3 The National High Field Magnet Laboratory, Florida State University, Tallahassee, FL

Abstract The peptide fraction of human milk was purified using acid precipitation, liquid‐liquid extraction and C18 solid phase extraction. Peptides purified from samples of milk collected at different times postpartum (weeks 1, 7, 12, 16) from mothers who delivered full‐term infants (>37 weeks gestation) and mothers delivering pre‐term infants (< 36 weeks post partum, milk collected during week 1,) were analyzed by matrix assisted laser desorption ionization time‐of‐flight (MALDI‐TOF) mass spectrometry (MS). For comparison and to aid in the identification of confidently observed peptide masses, one sample representing a pool of milk collected during the first week postpartum was fractionated by nano‐high performance liquid chromatography (n‐HPLC) and fourier transform ion‐cyclotron resonance (FT‐ICR) coupled to electrospray ionization MS/MS followed by database searches using MASCOT.

The representative mass profiles for each time‐point was determined by extracting the peptide masses that were confidently observed in a number of MALDI runs performed on each sample. The profiles obtained from each time‐point were then compared to each other to determine the masses that were ubiquitously expressed (week 1 through week 16), those masses that were observed in either early milk (week 1) or late milks (> week 12), and those masses that were observed in only preterm milk during the first week but appeared in full term milks later in lactation (at week 7 or later).

Thirty‐five masses were ubiquitously expressed in human milk. Thirty masses were only observed in milk collected during week one (full‐term and preterm) but not later milks (full‐term); whereas only five distinct masses were observed only in late milks (full‐term).

As an interesting note, twenty‐five masses were observed only in preterm milk collected during week one but then appeared in full‐term milk much later in lactation (week 7 or later).

A number of masses that were observed by MALDI were identified as peptide hormones 140

TECHNICAL ABSTRACTS that were expected to be in human milk such as bombesin‐like peptide (theoretical mass 2082.1 Da, experimental 2082.11) somatostatin 14 (theoretical mass 1636.7 Da, experimental 1635.22), IGF‐I (theoretical mass 2481.1 Da, experimental 2481.1) endothelin‐I (theoretical mass 2491.9 Da, experimental 2490.89). A database search of MS/MS data obtained by FT‐ ICR/ESI MS/MS helped to further identify peptide masses that could not be identified by mass alone using MALDI‐MS data. Many of the masses observed by FT‐ICR/ESI‐MS/MS were identified as beta‐casein fragments (MALDI‐MS masses: 2239.94, 2255.93, 2381.07, 2458.68, 3022.27, 3150.10; FT‐ICR‐MS masses: 2238.22, 2255.2, 2382.31, 2458.7, 3021.74, 3149.76).

2:25 PM – 2:45 E.I. Dupont Fellowship Awardee “In Vitro Oxidative Folding Partners: Studying the Cooperation of PM Quiescin Sulfhydryl Oxidase (QSOX) and Protein Disulfide Isomerase (PDI)”

Pumtiwitt C. Rancy*1, Jakob R. Winther2, Colin Thorpe1

1University of Delaware, Department of Chemistry and Biochemistry, Newark, DE 2University of Copenhagen, Department of Molecular Biology, Copenhagen, Denmark

Abstract

Disulfide bonds serve structural, regulatory, and/or catalytically important roles in many physiologically relevant proteins. However, the means by which disulfide bonds are introduced into thiol‐containing proteins in multicellular organisms remains, remarkably, poorly understood. The overall goal of this work is to better understand the enzymatic processes involved in oxidative protein folding in the mammalian endoplasmic reticulum (ER). The focus of this research is to determine the dynamics of QSOX and PDI cooperation in protein disulfide bond formation. QSOX is an ER‐resident flavin‐ dependent enzyme that catalyzes the oxidation of protein thiols to disulfide bonds with concomitant reduction of oxygen to hydrogen peroxide. These enzymes are very efficient with turnover numbers of ~ 1000 disulfides formed per minute but introduce primarily incorrect disulfide pairings. These mispairings are then corrected by protein disulfide isomerase (PDI). PDI, which is also found in the ER, catalyzes the isomerization of mismatched disulfide pairs to native ones. Previous work by this lab has shown the cooperation of QSOX and PDI in the refolding of a relatively simple protein with 105 disulfide isomers, reduced ribonuclease (RNase) in vitro. The current work revisits this scheme in an effort to discern the mechanistic aspects of these interactions.

In particular, we have recently developed a novel in vitro folding system that can 141

TECHNICAL ABSTRACTS efficiently refold riboflavin binding protein (RfBP). RfBP contains 9 disulfide bonds and therefore offers a much stiffer test to our system (it has 32 million disulfide isomers).

Current work compares this new system with prior in vitro folding methods for disulfide‐ containing proteins.

2:45 PM – 3:05 Procter and Gamble Fellowship Awardee “Analysis Of Pesticides In Hair By Comprehensive Two‐Dimensional PM Gas Chromatography”

Charlotte A. Smith‐Baker*1, Mahmoud A. Saleh1, and J.‐M. D. Dimandja2

1Texas Southern University, Department of Chemistry, Houston, TX 2Spelman College, Department of Chemistry, Atlanta, GA

Abstract The objective of this talk is to describe the development of a new non‐invasive method for the analysis of toxicological biomarkers for exposure to pesticides. The method is based on comprehensive two‐dimensional gas chromatography (GCxGC), which subjects the analytes to two separation columns through the use of an on‐column injector called a modulator. The primary advantage of GCxGC over conventional one‐dimensional GC techniques in this particular application is a simplification in the sample preparation procedure, which results a substantial improvement in analytical throughput. The presentation will focus on the development of the GCxGC method and an evaluation of the qualitative and quantitative figures of merit of the technique.

3:05 PM – 3:25 Lendon N. Pridgen, GlaxoSmithKline ‐ NOBCChE Fellowship Awardee “Total Synthesis of Phomopsins” PM

Brandon T. Kelley and Madeliene Joullie Department of Chemistry, University of Pennsylvania, Philadelphia, PA Abstract Phomopsins are naturally occurring heterodetic peptides with a 13‐membered cyclic core structure with a unique tertiary alkyl‐aryl ether linkage. The cyclic core and linkage found in phomopsins are similar to that in ustiloxins, however ustiloxins have an isopropyl or methyl group in place of the isopropenyl group that is found in phomopsins. Because of their similarities it is of our interest to synthesize an ustiloxin analogue, containing the isopropenyl group instead of the isopropyl or methyl group. We plan to approach the total synthesis to phomopsins and the ustiloxin analogue using an ethynyl aziridine ring opening reaction that was discovered in our laboratory.

142

TECHNICAL ABSTRACTS

Thursday, AM

Technical Session 11

9:00 AM – 11:05 AM Room 410 Lloyd Ferguson Young Scientist Award Symposium Session Chair Odalapo Bakare Department of Chemistry, Howard University

Presenters

9:00 AM – Lloyd Ferguson Young Scientist Award Winner “Engineering Novel Hemoglobin‐Based Oxygen Carriers For Use In 9:30 AM Transfusion Medicine”

Andre F. Palmer

Department of Chemical & Biomolecular Engineering, The Ohio State University Columbus, Ohio

Abstract Universal oxygen‐carrying solutions that can replace the oxygen storage and transport functions of red blood cells will improve clinical outcomes both for trauma victims and for patients undergoing high‐blood‐loss surgical procedures. These oxygen carriers also will prevent the many serious complications associated with blood transfusions. My talk will address three engineering approaches for designing hemoglobin‐based oxygen carriers.

Our design strategy is based on the observation that transfusion of hemoglobin results in vasoconstriction and the development of systemic hypertension. The root cause of this effect stems from the ability of hemoglobin to extravasate through pores in the wall of blood vessels and sequester NO from the surrounding vasculature. This in turn leads to blood vessel constriction and results in the observed hypertensive effect. Therefore, our design strategy will focus on increasing the size of hemoglobin‐based oxygen carriers so that they are unable to traverse across the wall of blood vessels. In this talk, I will discuss the design of polymersome encapsulated hemoglobins, polymerized hemoglobins and surface conjugated hemoglobins. This work is significant in that it will lead to the development of novel oxygen carriers for therapeutic use.

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TECHNICAL ABSTRACTS 9:30 AM – 9:45 AM

“Design And Synthesis Of Novel Hemoglobin Crosslinks Based On Phosphonate Mimics On 2, 3‐Bisphosphoglycerate”

Tigist W. Kassa, Jason S. Matthews, Faith A. Brown Department of Chemistry, Howard University, Washington, D.C. Abstract

Hemoglobin (Hb) being the natural oxygen carrier inside the red blood cell (RBC) has been the preferred choice for developing such substitute. However, there are two principal problems that must be overcome to utilize hemoglobin as a blood replacement. First, it suffers from short circulation times in the blood stream (1‐4hrs) due mainly to its breakdown from a large tetrameric protein, ʺ1ʺ2$1$2, into two smaller dimmer dimeric units, ʺ1$1 and ʺ2$2, resulting in its rapid renal elimination and afflicting considerably renal toxicity. Secondly, the increase in the oxygen affinity of hemoglobin because of the absence of 2,3‐bisphosphoglycerate limits the unloading of oxygen to the tissues. These drawbacks have been attributed to the loss of the natural allosteric effector of Hb, called 2,3 bisphosphoglycerate (BPG), upon isolation of pure stroma‐free Hb from RBC. We have designed compounds which mimic BPG outside RBC and can crosslink Hb tetramer in the $ cleft. ʺ,ʺ‐Difluoro substituted phosphonates are one class we intend to explore as 2, 3‐ bisphosphoglycerate analogues and have devised a synthetic scheme for. Squaric acid derivatives (squaramides) are a second class of phosphonate analogues that will be explored. These BPG analogues are expected to crosslink Hb dimmers at the positive amino acid sites where normally BPG stabilize the $ dimmers in RBC.

9:45 AM – 10:00 “Synthesis of Ether Derivatives of (S)‐Nicotine” AM

Pauline W. Ondachi and Daniel L. Comins*

Department of Chemistry, North Carolina State University, Dabney Hall, Campus Box 8204, Raleigh, NC

Abstract Nicotine and its derivatives have in the recent past drawn a lot of interest due to their potential pharmacological role in the treatment of Central Nervous System (CNS) related diseases. One area of research the Comins group has been undertaking is development of novel methodologies for synthesis of enantiopure nicotine derivatives using commercially available (S)‐nicotine as a cheap starting material. A variety of acyclic and cyclic ether derivatives have been synthesized. Synthesis of C‐6 alkoxy derivatives was achieved through copper‐mediated reactions in two steps from (S)‐nicotine. Cyclic derivatives were 144

TECHNICAL ABSTRACTS synthesized through directed metalation and palladium‐catalyzed reactions.

O

4 5 6

3

N

N

N

N R

2

O

O

N

N

1

(S)-Nicotine

10:00 AM – 10:10 AM

10:10 AM – 10:25 AM

Break

“The Development Of Anion Sensors And Their Characterization” Yousef Hijji*, Belygona Barare Chemistry Department, Morgan State University, Baltimore, MD Abstract

Anions play an important role in biosystems and the environment. The detection of the anion is important in monitoring the level of these anions to the safe levels. Fluoride is one of these anions that can cause fluorosis, toxicity, and dental cares. In addition fluoride is one of the hydrolysis products of the nerve gases as sarin, which necessitate the development of a sensitive selective fluoride sensor. Other anions as acetate and dihydrogen phosphate are important in many biological processes in living cells.

We have designed and developed new sensors that contain new receptor sites not reported before for anion sensors. These receptors are imines and hydrazones formed very easily, efficiently and in high yield. The receptors are attached to signaling systems that involve excited state proton transfer mechanism. The reporting units are conjugated aromatic systems that vary in substitution allowing for the prediction of the absorption maxima resulting from the interaction with the anions.

These sensors showed sensitivity and selectivity for fluoride, acetate, and dihydrogen phosphate in the presence of other anions as chloride, bromide, perchlorate and hydrogen sulfate. The solvent can have an affect that can allow the selectivity of acetate over fluoride and dihydrogen acetate.

In this presentation the UV‐vis and visual detection of these anions will be presented in addition to the design and influence of the substitution on the behavior of these sensors, the structures, the future direction and application of these sensors.

Support was provided by DOE‐CETBR grant No. DE‐FG02–03ER63580 and NSF‐RISE Award No. HRD‐0627276.

145

TECHNICAL ABSTRACTS “Synthetic Studies On The Mdma (“Ecstasy”) Antagonist Nantenine” 10:25 AM –

10:40 AM 1Onica Le Gendre, 2Stevan Pecic, 1‐3Wayne W. Harding*

1Department of Chemistry, Graduate Centre, CUNY, 365 5th Avenue, New York, NY 2Department of Biochemistry, Graduate Centre, CUNY, 365 5th Avenue, New York, NY 3 Department of Chemistry, CUNY, Hunter College, New York, NY

Abstract

MDMA (“Ecstasy”) is a synthetic phenethylamine stimulant which is known to affect the re‐uptake of serotonin, dopamine and nor‐epinephrine in the brain. Adverse effects of consumption of “Ecstasy” in humans include development of hyperthermia, hallucinations, organ failure and in extreme cases, death. Nantenine is a naturally occurring aporphine alkaloid which has been shown to block and reverse behavioural and physiological effects of MDMA in mice. There is evidence that the behavioural and physiological effects of MDMA are mediated by α1‐adrenergic and 5‐HT2A receptors and nantenine has been shown to antagonize these receptors. However, we do not know the relative role that these receptors play in mediating the MDMA antagonizing effects of nantenine in vivo.

The goal of this project is to explore routes to synthesize nantenine and derivatives. These compounds will be tested for antagonist activity at α1‐adrenergic and 5‐HT2A receptors and for their ability to block the effects of MDMA in mice through drug discrimination assays in vivo. This work will allow us to gain insights into the relative role of these receptors in the antagonistic activity of nantenine and lay the foundation for the design and development of potent and selective MDMA antagonists in future.

We have explored a number of routes to the synthesis of nantenine and analogues and will present details of our synthetic studies as well as the results of biological evaluations of nantenine and analogues herein.

“Glucosamine Schiff Bases As Anion and Cation Sensors” 10:40 AM – 10:55 AM

Solomon Tadesse*, Yousef M. Hijji and Alvin P. Kennedy Morgan State University Department of Chemistry, Baltimore, MD Abstract The design of host molecules that can recognize and sense anions selectively through visible, electrochemical and optical responses has received considerable interest in recent 146

TECHNICAL ABSTRACTS years because of the important roles played by the anions in biological, industrial and environmental processes. Similarly, recent work on carbohydrate based switch–on molecular sensor for Cu (II), development of colorimetric sensor for ATP in Aqueous solutions and fluorescence methods for determining aluminum ions in water samples using schiff bases (SB) derived from amino sugars has been documented. In this study SBs derived from the reactions of Glucosamine with 2‐Hydroxy Naphthaldehyde, schiff base‐ 1 (SB‐1 ), and Glucosamine with Salicylaldehyde, Schiff base‐2 (SB‐2), were prepared and the identity of the compounds were confirmed using Differential Scanning Calorimeter (DSC), Infra Red (IR) Spectroscopy and Nuclear Magnetic Resonance (NMR). The potentials of the compounds in the development of colorimetric and fluorescence chemosensors was investigated by studying changes in the absorbance and fluorescence behavior in the presence of cations and anions.

“Synthesis And Biological Evaluation Of Steroidal Based 10:55 AM – Aminoalkyloxy Derivatives Of Estrone As Potential Anti‐Breast 11:10 AM Cancer Agents”

Devora A. Simmons and John S. Cooperwood*

College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, FL

Abstract Breast cancer is second to cardiovascular disease in causing death in women between the ages of 35 and 55 years. It is also the second most common cause of death in women older than 55 years of age. Estrogens are important hormones in the female body. These steroids interact with multiple organ systems and make major impacts on the physiological events that occur throughout the female’s life. Among the estrogens, estradiol is the most potent because of its high binding affinity for the estrogen receptors. Tamoxifen, a therapeutically and clinically available SERM has been shown to be effective in the treatment of breast cancer. Nevertheless, tamoxifen have been associated with endometrial cancer due to its estrogenic activity within the uterus. Several chemically unrelated compounds have been found to demonstrate activities similar to that of SERMs through interaction with estrogen receptors. Thus, our objective is to synthesize compounds by combining a portion of the chemical features of tamoxifen, the aminoalkyloxy functional group, with the rigid structure of estradiol and compare the activity. Through modifications of the 3‐OH position on the Estradiol A‐ring with different aminoalkyloxy derivatives; and opening the D‐ring at the 17th position with the addition of certain functional group moieties, the synthesis of these compounds have been achieved. Receptor binding assays and gene proliferation studies are being carried out evaluate their effectiveness in treatment of breast cancer. The activity of these compounds will be evaluated using MCF‐7 cells, in 147

TECHNICAL ABSTRACTS vitro, through the following studies: receptor binding studies, gene proliferation assays and gene expression. In synthesizing these specific types of compounds, the direction is to show that have activity equal to or better than that of 4‐hydroxytamoxifen, the active metabolite of Tamoxifen. Therefore, these compounds could be of use in the market for effectively treating patients affected by breast cancer.

Thursday, AM

Technical Session 12

9:00 AM – 11:00 AM Room 407 NOBCChE Professional Chemical Engineering Award Symposium Session Chair Issac Gamwo US Department of Energy, Pittsburgh, PA Presenters

9:00 AM – 9:40 NOBCChE Professional Chemical Engineering Awardee “Reducing The Rate Limiting Step In Chemical Engineering Growth” AM

Christine S. Grant

Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC grant@eos.ncsu.edu

Abstract Technological advances have resulted in modern marvels promising the solution of a myriad of complex global problems improving the lives of all world citizens. The emergence of chemical engineers as leaders impacting health care and environmental sustainability on a global scale has reshaped the traditional education to incorporate new technologies based on fundamental principles. We now have courses on nanotechnology, bioprocessing and sustainability as educational tracks in the CHE curriculum providing industry with a new breed of chemical engineer. While women are 50% of the world’s citizens, they only make up less than 20% of the professional engineers; African‐ Americans make up less than 5 % of the practicing chemical engineers. One must ponder the potential impact that true CHE diversity could have on the growth of future interdisciplinary, multinational engineering collaborations. Engineers, engineering educators and engineering societies have prided themselves on solving complex, multivariable problems for hundreds of years. Somehow, however, the profession has not succeeded in applying this same problem solving skill set to the diversification of engineering. Dr. Christine S. Grant, a recipient of the 2003 National Science Foundation’s Presidential Award for Excellence in Science, Math, Engineering Mentoring and a recent 148

TECHNICAL ABSTRACTS member of the American Institute of Chemical Engineers Board of Directors will describe successful strategies to increase minority and women engineers in both academia and industry. Grant will utilize examples of her own research and teaching activities to illustrate collaborative approaches to future chemical engineering endeavors. The presentation will also explore the synergies in the lessons learned globally and in the United States in the utilization of this powerful untapped talent pool.

9:40 AM – 10:00 “Synthetic Biology: Potential and Implications of an Emerging Field” AM

Michael Gyamerah*

Prairie View A&M University, Department of Chemical Engineering, Prairie View, TX

Abstract The emerging field of synthetic biology promises the launching of an industry in the 21st century characteristic of the chip industry in the 20th century.

The driving force for this field is the mindset of its proponents, many of whom are engineers, and who are bringing their engineering approach to systems analysis to bear on biology. As in the computer industry where predictability and reliability have been established, synthetic biologists seek to build on well‐established strategies of standardization, decoupling and modeling of biological parts, devices and systems.

Here, we present the potential impact and implications of synthetic biology and the need to train its future work force. A NSF Synthetic Biology Research Center (SynBERC) with headquarters at University of California, Berkeley with participation from UC San Francisco, MIT, Harvard and Prairie View A & M University (an HBCU), which provides a unique opportunity for research training and education of minority biological and engineering students are highlighted.

“Non‐Catalytic Esterification Of Organic Acids In Supercritical 10:00 AM – Alcohol” 10:20 AM Kehinde S. Bankole and Gary A. Aurand* The University of Iowa, Department of Chemical and Biochemical Engineering, Iowa City, IA

Abstract Environmentally friendly solvents and renewable chemicals are receiving increased attention due to their excellent properties, which allow them to replace toxic halogenated solvents and glycol ethers. One environmentally friendly solvent that has potential for 149

TECHNICAL ABSTRACTS increased application is ethyl lactate. Ethyl lactate can be produced from the esterification reaction of ethanol and lactic acid, two feedstocks obtained from renewable resources.

However, esterification is a slow equilibrium‐limited reaction. Recently, both heterogeneous (acidic ion‐exchange resins) and homogeneous (sulfuric acid) catalysts are being used in esterification reactions with excess alcohol to achieve high reaction rate and conversion. These catalytic approaches are inherently undesirable due to some drawbacks, such as (1) complex unit operations for catalyst separation and purification of product from the reaction mixture, (2) excess water formation due to dehydration of alcohol, (3) formation of yield‐reducing by‐products via undesired side reactions, and (4) harmful environmental impact due to the formation of sulfites. In this work, the non‐ catalyzed esterification of lactic acid in supercritical ethanol to form ethyl lactate has been investigated. Kinetic parameters will be presented, as well data regarding the effect of reaction temperature on equilibrium conversion. The non‐catalytic approach shows promise as an alternative to the traditional esterification processes, which use catalysts and excess alcohol.

“Social, Economic And Environmental Metrics For The 10:20 AM – SUSTAINABLE Optimization Of Chemical And Petroleum 10:40 AM Processes”

Karen A. High* and Olamide O. Shadiya

Oklahoma State University, Department of Chemical Engineering, Stillwater OK

Abstract

This research is focused on investigating sustainability metrics for the optimization of chemical and petroleum processes. Traditionally, engineers designed processes to meet economic goals; however with the awareness of sustainability, engineers are now considering other constraints such as resource usage, environmental impacts, social benefits and economics. Several metrics and indicators for quantifying sustainability exist; yet, there is no straight forward computer aided tool and path that engineers can follow in order to design for sustainability. Investigating and validating available indexes and metrics and implementing the three major sustainability criteria into process design and optimization are the goals of this research. A well defined methodology that will include process optimization under social, economic and environmental constraints is being developed. This involves building upon existing multi‐objective algorithms that handle selected sustainability criteria and constraints. This research will contribute to sustainability development in process design. This talk will introduce our methodology as well as present results from evaluating existing metric systems.

150

TECHNICAL ABSTRACTS 10:40 AM – 11:00 AM

“Electrospinning” Tivern H. Turnbull Hampton University, Hampton, VA

Abstract Electrospinning is a process used to create non‐woven nano‐sized fibers. Electrospinning is a very simple process with a promising future. Extensive literature research has led to the belief that electrospinning may be used in the following areas: filtration, textiles, clothing, electronics, and the medical field. At Hampton University, many different materials will be electrospun and examined for their possible applications. In the Electrospinning process, a polymer solution is mixed. The polymer solution is placed into a syringe and a metal needle is placed at the end of the syringe. The syringe is then placed into a syringe pump, which is set to a desired rate at which the solution will be pumped out of the needle. An alligator clip connected to a power source is placed onto the needle.

A grounded target, that will collect the fibers produced, is then placed at a desired distance from the tip of the needle. A light/heat source is placed over the distance between the needle and the target to ensure all the solvent is evaporated from the fibers during spinning. The power source and the syringe pump are turned on and the electrospinning begins. Several variables will be changed to obtain a desired outcome and also to find the optimum processing conditions for each material. Our variables include: Voltage applied, needle tip to target distance, solution concentration and pump rate. Changing these variables will vary the diameter of the fibers which is measured using the Scanning Electron Microscope (SEM).

Thursday, AM

Technical Session 13

9:00 AM – 11:15 AM Room 406 Analytical Chemistry Session Chair William Adeniyi Department of Chemistry, North Carolina A&T University

Presenters

9:00 AM – 9:20 “Analysis Of Trace Nickel At Iridium‐Based Ultramicroelectrode Arrays By Adsorptive Stripping Voltammetry” AM

Joseph Wang*1, and Jiayang Wang2, and William K. Adeniyi3

1Director, Center for Bioelectronics and Biosensors, The Biodesign Institute, Arizona State University, Tempe, AZ 2Department of Chemistry and Biochemistry, New Mexico State University, 151

TECHNICAL ABSTRACTS Las Cruces, NM 3Department of Chemistry, North Carolina Agricultural and Technical State University, Greensboro, NC

Abstract Stripping techniques, which are widely used in electrochemical procedures, generally involve an initial accumulation of analytes, commonly from a stirred solution. The accumulation occurs on the surface of a stationary working electrode. The effectiveness of this initial step lies in the fact that the concentration of the analyte on the surface of the electrode is far greater than it is in the bulk solution. The analyte is pre‐concentrated either as a metal or in the form of a known compound by controlled potential electrolysis or adsorption. The pre‐concentration species is then stripped from the surface of the electrode by reduction or oxidation. The response recorded during this step is proportional to the concentration of the analyte.

Adsorptive stripping uses the formation of an appropriate metal chelate, followed by its control interfacial accumulation onto the working electrode. The adsorbed metal chelate is then reduced by application of a negative‐going potential scan.

The adsorptive accumulation technique is very efficient, making it possible to achieve a detection limit down to the 10‐10 M level. The high sensitivity is achieved by optimization of experimental variables, such as pH, accumulation time, stirring conditions, accumulation potential, etc.

The most commonly used electrodes in stripping analysis include the hanging mercury dropping electrode (HMDE), thin mercury film electrode (TMFE), mercury‐coated platinum and glassy carbon(GCE).

In this investigation, a new, relatively unknown electrode, is being used for trace analysis of nickel. Lithographically fabricated iridium‐based mercury microelectrode arrays are shown here to be equally suitable for adsorptive stripping measurements of trace nickel in the presence of dimethylgloxime agent. A detection limit as low as 0.5 μg/mL with 30s adsorption is achieved, with good linearity. and excellent precision. The suitability of the technique for on‐site analysis of trace amounts of metals that cannot be plated electrolytically is investigated.

152

TECHNICAL ABSTRACTS 9:20 AM – 9:40 AM

“Metabolite Analysis Using Microfluidic Platforms”

Gloria T. MaGee, Hui Chen* Xavier University of Louisiana, New Orleans, LA *Mississippi State University, MS State, MS

Abstract Much of research in microfluidics aims to develop better tools for addressing inherently demanding challenges in biological sciences. As an analytical tool, microfluidics offer many potential advantages, such as smaller sample and reagent volumes required (decreased cost) and faster analysis with no loss in data integrity.

The particular research described herein involves the development of microfluidic methods in application to metabolomics ‐ the study of metabolite profiles as unique chemical fingerprints of specific cellular processes. In this work, the development of free‐ solution and hydrogel‐based electrophoretic methods for metabolite target analysis of estrogen will be presented. Specificity, linearity, advantage and limitations of the methods will be compared with conventional methods. These microfludic methods could be appropriate for a wide range analyses in microbial, plant, animal and human metabolomics.

9:40 AM – 10:00 AM

“Characterization Of Self‐Assembled Monolayers That Resist Protein Adsorption Using Spectroscopic Ellipsometry”

Marlon L. Walker1*, David J.Vanderah2, and Kenneth A. Rubinson3

1Surface and Microanalysis Science Division 2Biochemical Sciences Division National Institute of Standard and Technology, Gaithersburg, MD

3Department of Biochemistry and Molecular Biology, Wright State University, Dayton, OH and Electronics and Electrical Engineering Laboratory, National Institute of Standard and Technology, Gaithersburg, MD

Abstract

The adsorption of a disulfide [S(CH2CH2O)6CH3]2 {[S(EO)6]2} and two thiols HS(CH2)3O(CH2CH2O)5CH3 {C3(EO)5} and HS(CH2CH2O)6CH3 {(EO)6} from aqueous 153

TECHNICAL ABSTRACTS solution onto Au was examined using in‐situ spectroscopic ellipsometry. The resultant self‐assembled monolayers (SAMs) formed by each compound were evaluated for non‐ specific protein adsorption resistance. Bovine serum albumin adsorption studies on [S(EO)6]2 showed dramatic reduction in the amount of adsorbed protein compared to surfaces of Au and SAMs of octadecane thiol (ODT), C3(EO)5 and (EO)6. The behavior of the disulfide compound was clearly different than the thiols, in both limiting model thickness and assembly behavior. Water contact angle measurements were essentially similar for SAMs formed from all three compounds, the disulfide being slightly more hydrophilic. These results demonstrate the in‐situ formation of oligo(ethylene oxide) SAMs from water and support the premise that SAMs composed of surface‐bound, conformationally mobile molecular chains with interior hydrophilicity are needed for significant protein adsorption resistance.

Break 10:00 AM – 10:05 AM

“Research At The Savannah River National Laboratory; From The 10:05 AM – 10:25 AM Laboratory To The Field And Back” Amy A. Ekechukwu

Savannah River National Laboratory, Savannah River Site, Aiken, SC

Abstract The Savannah River Site (SRS) is a 300 square mile facility located in Aiken, South Carolina. The site contains nuclear separation facilities, nuclear waste processing facilities, environmental monitoring and remediation sites, and several laboratories. The site mission has shifted over the last 15 years from nuclear material production to environmental clean‐up and nuclear waste stabilization. The Savannah River National Lab (SRNL) is located at SRS. In addition to providing research and analytical support to plant operations, SRNL conducts research in the areas of environmental remediation, nuclear material characterization and stabilization, biotechnology, robotics, sensors, fuel cells, and other areas. As a national laboratory, SRNL participates in research partnerships with external companies and universities. These applied R&D programs support the site missions as well as Environmental Remediation, Energy, and Homeland Security.

Due to the diverse nature of the research programs at SRS, scientists at SRNL are able to participate in a wide range of research projects and experimental programs. This presentation will give an overview of some of the research projects in which the speaker has participated. The projects range from characterization of unknown material using classical analytical methods, characterization of nuclear waste for material stabilization 154

TECHNICAL ABSTRACTS purposes, field application of environmental rededication processes, bioremediation of spent nuclear material using bacterial degradation, sensors, process monitoring, and fuel cell research.

“The Pros And Cons Of Analyzing A Metal Ion By UV‐VIS Vs. HPLC” 10:25 AM – 10:45 AM Lamont Mckellar

Emerson Resources 600 Markley Street Norristown PA

Abstract

The oxidation state of some metal ions allows it to be easily identified. The natural color change of many metals ions when changing oxidation states lends itself to UV‐VIS analysis. UV‐VIS spectroscopy is a fast and very useful analytical tool, however it has some drawbacks. Reproducibility of results within a small %RSD can be difficult, it has no “set and forget” feature therefore you have to manually analyze each sample. In addition, the integrity of the container that holds the sample (cuvette) plays a critical role in obtaining accurate data; any dirt, cracks or scratches to the container can change your results. As an alternative analytical tool HPLC can be used. While HPLC offers some advantages over UV‐VIS it is not without its own drawbacks and challenges. This investigation examines the advantages and disadvantages of converting a dissolution method of a metal ion analyzed by UV‐VIS to a method analyzed by HPLC. In addition it compares and contrasts the two methods to determine which is more efficient for this specific metal complex.

“A New Talent Of The Known Ionophore: Selective Recognition Of 10:45 AM – Thallium(I) By 1,3‐Alternate Calix[4]Arene‐Bis(Crown‐6)” 11:00 AM

Ebony D. Roper, Vladimir S. Talanov, Raymond J. Butcher, and Galina G. Talanova*

Department of Chemistry, Howard University, Washington, DC

Abstract

1,3‐Alternate calix[4]arene‐bis(crown‐6), designed originally for selective separation of Cs+ from other alkali metal cations in nuclear waste treatment, has been found to possess even higher affinity for a soft electron acceptor Tl+. ‐Coordination of Tl+ with the calixarene aromatic framework plays an important role in the enhanced complexing ability of the ligand toward this metal ion. Solvent extraction data as well as solution and crystal 155

TECHNICAL ABSTRACTS structures of Tl+ complexes with 1,3‐alternate calix[4]arene‐bis(crown‐6) will be discussed in comparison with those for Cs+ and Rb+.

“Investigation Of Chemically Deposited Silver Films On Barium Titanate Beads As A Surface‐Enhanced Raman Scattering (Sers) Active Substrate For Detection Of Benzenethiol, 1, 2‐Benzenedithiol, 1, 4‐ Benzenedithiol, And Rhodamine 6G”

Jonathan I. Onuegbu†, Anqie Fu‡, Orest Glembocki‡, Shaka Pokes‡, Dimitri Alexson‡, and

11:00 AM – 11:15 AM

Charles M. Hosten*†

†Department of Chemistry, Howard University, Washington DC ‡Division of Electronics, Naval Research Laboratory, Washington DC

Abstract

We present here a novel study in which Ag films were deposited (chemically) on barium titanate (BaTiO3) beads using Tollen’s reagent to fabricate a SERS (Surface Enhanced Raman Scattering) active substrate. BaTiO3 beads (reflectory materials which return light to its source) of sizes from 400 – 600 μm were used. The time of deposition of Ag on the beads was varied from 3 – 60 minutes. We investigated the effect of the time variation on the substrate SERS sensitivity. It was observed that the beads with the deposition time of 20 – 30 minutes gave the most intense signals. Scanning electron microscope (SEM) images of Ag coated beads revealed that beads with deposition time of 10 minutes have small Ag film deposits, resulting into small roughness, while beads with 30 minutes have large Ag islands (resulting into large roughness); and beads at 60 minutes were completely covered with Ag films (resulting into little or no roughness). Benzenethiol, 1,2‐Benzenedithiol, 1,4‐ Benzenedithiol, and Rhodamine 6G were used as probe molecules to investigate the SERS sensitivity of the Ag‐coated beads. Lasers ranging from 351 – 785 nm were used.

156

TECHNICAL ABSTRACTS

Thursday, AM

Technical Session 14

11:30 AM – 1:00 PM Room 410 Bioapplications in Chemical Engineering Session Chair Derrick Rollins Department of Chemical Engineering, Iowa State University Presenters

11:30 AM – Highlighted Speaker “Biocatalysis and Bioprocessing Under Extreme Conditions: 12:00 PM Developing Sustainable Engineering Enhancements”

Tonya L. Peeples

Chemical and Biochemical Engineering, The University of Iowa Center for Environmentally Beneficial Catalysis Center for Biocatalysis and Bioprocessing.

Abstract Developing economically competitive processes which reduce the environmental footprint of chemical conversion remains a significant challenge to the wider application of biological catalysts. Still, the application of biological systems in the chemical process industries is valuable for the production of fuels, foods, pharmaceuticals, and other specialty chemicals. The Peeples research group is studying the biological manufacture of valuable products using both enzymatic conversion and microbial biotransformation. For sustainable development, combinations of biological and conventional catalytic systems provide great potential. These chemo‐enzymatic and multi‐phase conversions involve conditions of extreme temperature, pH, pressure as well as hydrophobicity. Biocatalysts under investigation include oxidative and hydrolytic enzymes, traditional fungal and microbial fermentation catalysts, and extremophilic microbes. Reactions under study include the conversion of high volume organic chemicals as well as of renewable lignocellulosic feedstocks. In addressing such conversions, organisms from extreme environments represent an expanding pool of untapped transformation capacity. Lessons from extreme systems are being used to engineer stability in more conventional biocatalysts. The expanded application of these research endeavors will establish biocatalytic conversions as environmentally beneficial and economically viable synthesis strategies.

157

TECHNICAL ABSTRACTS “Alternative Procedure To Control Pressure In The Microvasculature Of The Pallid Bat’s Wing”

Vannard W. Davis*2, Bryan Jennings, Sam Mullins, LaShasta Robinson,

12:00 PM – 12:20 PM

Felecia M. Nave2, Christopher Quick1

1Texas A&M University REU Summer Program, College Station, TX 2Prairie View A&M University, Department of Chemical Engineering, Prairie View, TX

Abstract The microvasculature system is a network of vessels used to transport blood from the heart to the rest of the body and then circulates back to the heart. Pressure is one of the many driving forces in the flow of the blood through microvasculature. High pressures, commonly referred as hypertension, can either rupture the blood vessels or cause them to perform at less than optimal efficiency. Low pressure, commonly referred as hypotension, can result in a reduction of blood flow to tissues or organs. In order to further understand how the microvasculature system functions, it is important to increase our understanding of what role pressure plays on the microvasculature system. Previous studies have investigated the relationship of pressure on the microvasculature using either anesthetized or euthanatized animals. Modeling a process from an anesthetized or euthanatized animal will decrease the effectiveness of the process on a model that has not been anesthetized or euthanatized. The two procedures do not show normal pressures throughout the microvasculature. Recently, a procedure was developed to study the microvasculature system without anesthesia or euthanatizing the animal model, but this procedure caused trauma to the animals. Once an animal model is harmed in anyway it can not be used for a period of time and on top of that your experiment is done. Our undergraduate research group investigated a new procedure in order to eliminate any trauma to the animal model yet still study the effect of pressure on the microvasculature system. This presentation presents detailed discussion of the new procedure that was developed and a comparison of results between the previous method and the new method.

158

TECHNICAL ABSTRACTS 12:20 PM – 12:40 PM

“Characterization Of Polymeric Microspheres Synthesized By Homogenization And Precision Fabrication”

Devin Y. Brown, Kalena D. Stovall, Dr. Daniel W. Pack*

Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana‐Champaign, IL

Abstract Poly(lactide‐co‐glycolide), or PLG, microspheres are a minimally‐invasive, and commonly used avenue for long‐term drug delivery. These spheres are fabricated using a variety of techniques. However, there is little information on the effect of fabrication technique on the release kinetics and morphology of such spheres. The objective of this project is to determine the effect of fabrication technique, particularly conventional homogenization/solvent extraction and precision fabrication, on the surface morphology and release kinetics of PLG microspheres. Precision particle fabrication provides precise control of the particle size and very narrow size distributions.

Bovine serum albumin, or BSA, was labeled with the fluorescent dye fluorescein isothiocyanate, and encapsulated in PLG microspheres of varying size and polymer molecular weight using both synthesis methods. For each set of spheres, the average sphere size obtained from homogenization was matched using precision fabrication. The protein dispersion within the microsphere and protein release profiles were determined using fluorescence spectroscopy and a BCA assay, respectively. The surface and internal morphology of the spheres was characterized using scanning electron microscopy. This study is ongoing. Previous research has shown clear distinction in release profiles achieved from PLG microspheres based on size. Therefore, studies are expected to show a clear distinction in the release profiles achieved between homogenizer and precision fabricated spheres, due to the wide distribution of sizes present in the homogenizer batches. It is anticipated that the surface morphology and porosity observed will be similar between the two fabrication techniques.

159

TECHNICAL ABSTRACTS 12:40 PM – 1:00 “The Bioeffects of Metallized Nanotubes”

PM

Edidiong Obot *1, Prathyush Ramesh1, Renard Thomas2, Prabakaran Ravichandran3, Govindarajan Ramesh3, Bobby Wilson4

1Space, Engineering, and Science Internship Program (SESIP), Texas Southern University, Houston, Texas 2NASA University Research Center, Texas Southern University, Houston, Texas 3Molecular Neurotoxicology Laboratory, Texas Southern University, Houston, Texas 4SESIP Program Director, Texas Southern University, Houston, Texas

Abstract The application of Carbon Nanotubes (CNT’s) in the field of modern medicine such as drug delivery, virus detection, molecular methods for disease diagnosis have recently started to emerge and hence they are expected for the large scale industrial production.

However the use of CNT`s in various fields, especially in medical applications raises serious concerns about health and safety issues. Currently there are several areas that are looking towards nanotechnology as a new form of enhancement, however because this kind of technology is so new we lack the knowledge of its various effects that could affect our society. In our study we tested the toxicity level of Single Wall, Multi‐Wall, and Metallized Carbon Nanotubes in lung epithelial cells. The purpose of our research is to determine the toxicity level of Metallized Carbon Nanotubes in lung epithelial cells. The purpose of our study relates to the possible affects in industrial workers due to inhalation testing. CNT’s could become airborne during manufacturing process and handling and would result in inhalation and skin exposure of workers to particles causing unknown toxic response.If we test the Metallized Carbon Nanotubes we can see what kind of effect it would have particularly in our pulmonary system. We believe that if there is an attraction between the cells and the Metallic Carbon Nanotubes then it will cause a toxic response in the cell. The research will consist of culturing a cell line of lung epithelial cells, exposing the lung epithelial cells to a Metallic Carbon Nanotube, Muti‐Wall Carbon Nanotubes, and Single Wall Nanotube and compare the outcome, checking the toxicity using MTT and live dead cell assays in order to its test the vulnerability or resistance, comparing its Reactive Oxidative Stress (ROS), and using Transmission Electron Microscope (TEM) and Scanning Electron Microscope (SEM) to determine if the nanoparticles entered the cell. Based on our results we were able to determine that Metallized Carbon Nanotubes are more toxic than Single‐Wall and Multi‐Wall Carbon Nanotubes. Results show there is a direct relationship between the number of cells dying and its Reactive Oxidative Stress.

160

TECHNICAL ABSTRACTS

Thursday, AM

Technical Session 15

11:30 AM – 1:00 PM Room 406 Organic Chemistry Session Chair Rebecca A. Tinsley Colgate‐Palmolive Co., Piscataway, NJ

Presenters

“Zr(IV)‐Catalyzed Tertiary Transamidation And Amide Metathesis 11:30 AM – Under Ambient Conditions” 11:50 AM

Nickeisha A. Stephenson, Samuel H. Gellman*, Shannon, S. Stahl*

University of Wisconsin‐Madison, Madison WI

Abstract

The carbon‐nitrogen bond of a carboxamide is chemically robust and generally requires harsh conditions to react. Tetrakis(dimethylamido)zirconium(IV) [Zr(NMe2)4] was found to be a suitable catalyst for the exchange reaction between a tertiary amide a secondary amine (tertiary transamidation eq 1) at mild temperatures. Using Zr(NMe2)4 transamidation can be achieved with N‐alkyl and N‐aryl amides. Zirconium(IV) catalyzed transamidation was found to be compatible with toluamides, heptanamides, acetamides and formamides.

Zr(NMe2)4 was also found to be a suitable catalyst for tertiary amide metathesis eq 2. It was found that exogenous amine was not necessary for this reaction to proceed. Like tertiary transamidation, amide metathesis proceeds under mild conditions. However, higher catalyst loading and longer reaction times are needed for this reaction .

The discovery of Zr(NMe2)4 as well a catalyst for tertiary transamidation and amide metathesis will be discussed as well as future applications of these reactions for use in dynamic covalent chemistry (DCC).

161

TECHNICAL ABSTRACTS 11:50 AM – 12:10 PM

“Synthesis Of Sodium cis‐12,13‐epoxy‐cis‐9‐octadecenyl Sulfonate From Vernonia Oil”

Nikki S. Johnson

Department of Chemistry, Howard University, Washington, DC

Abstract In an effort to synthesize new surface active agents (surfactants), we have embarked on the syntheses of those that have functionalized hydrophobic chains from renewable starting materials. Thus a water‐soluble, foaming epoxyalkene sulfonate, sodium cis‐12,13‐epoxy‐cis‐9‐octadecenyl sulfonate, has been synthesized from vernonia oil (VO) by a series of simple reactions that include transesterfication, metal hydride reduction, tosylation, and SN2 reactions. Conversion of VO into vernonia oil methyl esters (VOME) using sodium methoxide was quantitative. Subsequent reduction of VOME with lithium aluminum hydride yielded cis‐12,13‐epoxy‐cis‐9‐octadecenol (78%), along with minor amounts of hexadecenol, octadecenol, cis‐9‐octadecenol, and cis‐9,12‐ octadecandienol. The cis‐12,13‐epoxy‐cis‐9‐octadecenol, was tosylated with p‐ toluenesulfonyl chloride to give cis‐12,13‐epoxy‐cis‐9‐octadecenyl tosylate at 96% yield.

Iodination of the tosylate with sodium iodide and subsequent SN2 reaction with sodium sulfite afforded cis‐12,13‐epoxy‐cis‐9‐octadecenyl sulfonate (63% yield).

This study demonstrates the ability to produce an epoxyalkenyl sulfonate, belonging to a class of anionic surfactants, from vernonia oil without destroying the epoxy functionality in the cis‐12,13‐epoxy‐cis‐9‐octadecenyl moiety of vernonia oil.

Faculty Advisor: Folahan O. Ayorinde, Ph.D

“Design And Sythesis Of Low Band Gap Poly(Thienylene Vinylene‐S, 12:10 PM – S‐Dioxide‐Thienylenevinylene) For Optpelectronic Application” 12:30 PM Thuong Nguyen *, Dr. Cheng Zhang , Dr. Sam Sun Norfolk State University, Center for Materials Research, Norfolk, VA

Abstract

A low energy gap sulfone substituted thienylene vinylene co‐polymer (SF‐PTV) with alternating donors and acceptors monomers units has been synthesized and characterized.

The donor monomer is 3,4‐dihexyloxy thiophene‐2,5‐dicarbaldehyde, and the acceptor monomer is 2,5‐bis(dietholxyphosphorylmethyl)‐3,4‐dihexyl‐1, 1‐dioxo thiophene. The (SF‐PTV) is very soluble in organic solvents such as tetrahydrofuran and chloroform at 162

TECHNICAL ABSTRACTS room temperature. UV‐VIS and Cyclic voltammeter (CV) analysis give an optical energy gap of 1.50 eV, HOMO level of ‐4.95 eV and LUMO level of ‐3.45 eV. Differential scanning calorimeter (DSC) shows a decomposition onset temperature of 200 °C. The SF‐PTV solid is stable during the thirty minutes test at 160 °C as verifying by H‐NMR. Thermal gravitational analysis (TGA) exhibits a 5% weight loss temperature of 259 °C. These two ends functional SF‐PTV would be very useful for various polymer application at 1.50 eV.

“The Synthesis Of Silylated 1,3‐Alternate Calixarenes” 12:30 PM –

12:50 PM Prima R. Tatum, Paul F. Hudrlik, and Anne M. Hudrlik

Department of Chemistry, Howard University, Washington, D. C. prima.tatum@gmail.com Abstract Silylated calixarenes are of potential interest in molecular recognition. Recently a number of C‐silylated cone calix[4]arenes [Me3Si, PhMe2Si, Ph2MeSi, (allyl)Me2Si] have been prepared in this research group. We are now investigating the synthesis of C‐silylated calixarenes in the 1,3‐alternate conformation. p‐tert‐Butylcalix[4]arene was dealkylated, and the 1,3‐alternate conformation was established via the two‐pot procedure of sequential treatment with propyl iodide/K2CO3 followed by propyl tosylate/CsCO3. The corresponding bromocalixarene was prepared using NBS. Silylation was carried out via halogen‐metal exchange using tert‐BuLi, followed by silylating agents (Me3SiCl and PhMe2SiCl) giving the silylated 1,3‐alternate calixarenes. As before, a mixture of chlorosilane with triethylamine was used for the silylations.

Silyl groups having electronegative atoms frequently become pentacoordinate or hexacoordinate via interaction with anions. The HMe2Si group is of particular interest because it has the potential to be converted to a silicon group having a more electronegative atom such as F or O. We have used the (allyl)Me2Si group for this purpose with cone calixarenes. However, some of the (allyl)Me2Si calixarenes were not crystalline.

The compact nature of the HMe2Si group suggests that HMe2Si calixarenes should be crystalline. We have therefore begun to carry out silylations using HMe2SiCl. The silylations proceeded similarly to those with Me3SiCl and PhMe2SiCl, and the silylation products from all three are crystalline. We are currently investigating methods for converting ArSiMe2H to ArSiMe2OH.

163

TECHNICAL ABSTRACTS

Thursday, PM

Technical Session 16

3:00 PM – 5:00 PM Room 412 Bioapplications in Analytical Chemistry Session Chair Murphy J. Keller III US Department of Energy, Pittsburgh, PA Presenters

3:00 PM – 3:30 Highlighted Speaker “In Situ Spectroscopy Of Operating Fuel Cells” PM

Eugene S. Smotkin

Department of Chemistry and Chemical Biology Northeastern University, Boston, MA

Abstract In‐situ x‐ray absorption spectroscopy, ex‐situ x‐ray fluorescence and x‐ray powder diffraction enabled detailed core analysis of phase segregated nanostructured PtRu anode catalysts in an operating direct methanol fuel cell (DMFC). No change in the core structures of the phase segregated catalyst were observed as the potential traversed the current onset potential of the DMFC. The methodology was exemplified using a Johnson Matthey unsupported PtRu (1:1) anode catalyst incorporated into a DMFC membrane electrode assembly. During DMFC operation the catalyst is essentially metallic with half of the Ru incorporated into an FCC Pt alloy lattice and the remaining half in an amorphous phase. The EXAFS analysis suggests that the FCC lattice is not fully disordered. The EXAFS indicates that the Ru‐O bond lengths were significantly shorter than that reported for Ru‐O of ruthenium oxides suggesting that the phases in which the Ru reside in the catalysts are not similar to oxides. In‐situ FTIR of operating fuel cells will also be discussed as well as cell design for an all‐in‐one spectroscopy cell for XAS and FTIR analysis of operating fuel cells.

3:30 PM – 3:45 “An Investigation Of Lysine Based Molecular Micelles As Coatings For Protein Separations In Open Tubular Capillary PM Electrochromatography”

Leonard Moore Jr, Arther T. Gates, Candace Luces, Mark Lowry, and Isiah Warner* Louisiana State University, Chemistry Department, Baton Rouge, LA

Abstract Protein separation using open tubular capillary electrochromatography (OT‐CEC) can be 164

TECHNICAL ABSTRACTS difficult due to analyte wall adsorption. In this work, two novel zwitterionic molecular micelles, α‐sodium‐10‐undecenoyl lysinate (α‐SUK), ε‐sodium‐10‐undecenoyl lysinate (ε‐ SUK), were synthesized and evaluated as coatings for OT‐CEC protein separations. A mixture of four basic proteins (lysozyme, cytochrome c, α‐chymotrypsinogen A, and ribonuclease A) were investigated. These novel zwitterionic molecular micelles allow increased control over the electrosmotic flow (EOF) with greatly diminished EOF values at pH values approaching the theoretical pI of the zwitterionic micelle coatings (pI~ 5.5 and 6.2 respectively). This preliminary work shows promise for the use of lysine‐based molecular micelles in OT‐CEC protein biomarker separations.

3:45 PM – 4:00 “Towards A Defined 3D Substrate For Controlling Human Embryonic Stem Cell Fate” PM

Samira Musah1, Ratmir Derda1, and Laura Kiessling*1, 2

1University of Wisconsin‐Madison, Department of Chemistry, Madison, WI 2University of Wisconsin‐Madison, Department of Biochemistry, Madison, WI

Abstract Human embryonic stem (ES) cells hold considerable promise for the treatment of several diseases that are epitomized by dysfunction or loss of specific types of cells. Human ES cells are characterized by their ability to differentiate into any type of cell in response to chemical cues. In addition, human ES cells are capable of self‐renewing and can be propagated in culture indefinitely. Thus, because ES cells can be extensively expanded in culture, they represent a potentially unlimited source of cells for many applications.

Current methods of culturing human ES cells employ matrices that have undefined compositions in 2D environment. The use of 2D systems has limitations due to the nature of human ES cell growth. Human ES cells do not grow to confluence in monolayer, but stack upon each other to form aggregates that extend beyond 2D environments. Here we describe the fabrication of well‐defined 3D scaffolds for controlling human ES cell fate by incorporating chemical effectors. This strategy presents a powerful method for directing human ES cells fate and may facilitate their use in human medicine and related applications.

165

TECHNICAL ABSTRACTS “Development And Characterization Of Near‐Infrared Fluorescent Probes For Applications As Chemical And Biological Sensors”

Richard Williams, Yousef Hijji, Dwayne, Hill, Maurice Iwunze, Angela Winstead, Elizabeth Akapo, Ichhuk Karki, Divine Kebulu, Dharendra Thapa, and Isha Pradhan

Morgan State University, Chemistry Department, Baltimore, MD

Abstract The advantages of near‐infrared fluorescence analyses have been widely reported. To date, realizing the full potential of analytical applications that utilize near‐infrared fluorescence has been limited by the cost and availability of suitable fluorophores. An increased interest in microwave assisted synthesis has created techniques where the synthesis of a variety of near‐infrared fluorophores is now practical. Details of the development and characterization of a several compounds from the heptamethine cyanine dye family made from these techniques will be reported. Preliminary results that demonstrate their potential use as probes in chemical and biological sensor analytical applications will also be reported. Fluorescence resonance energy transfer (FRET), metal enhanced fluorescence analysis, and excited state charge transfer analyses, and cytotoxicity and cellular injury diagnosis are among the potential applications that will be discussed. Supported by DOE DE‐FG02 ER63580 and NSF HRD‐0627276.

4:15 PM – 4:30 “Effect Of Cyanine Constructs On Transformed Cell Populations” PM Dwayne Hill*1, Tolulope Ayangade1, Phillip Butler1, Michael Baker1, Colette Ntam1, 4:00 PM – 4:15 PM

Nicole Flemming2, Nikia Smith2, Devine Kebulu2, Angela Winstead2, Deshauna Curry2, Richard Williams2 and Laundetta Jones3.

Departments of Biology1 and Chemistry2Morgan State University, Baltimore, Maryland.

Department of Pharmacology and Experimental Therapeutics3, University of Maryland, Baltimore, Maryland

Abstract Organ systems and tissues are comprised of both heterogeneous and homogeneous cell populations. These various populations are essential for normal organ system and tissue function. A range of toxic chemicals and pollutants have been shown to cause severe cytotoxicity as well as induce the transformation of normal cells into malignant neoplasms. These alterations in normality could result in the genesis and propagation of malignant cancers and cytotoxic developments. Advances in technology and therapeutic regimens to treat or prevent the progression of these health adversities have been 166

TECHNICAL ABSTRACTS encouraging, however clinicians and researchers are still interested in using new and more specific applications. Fluorescent sensor technology has received significant interest in these regards. Studies have indicated that cyanine dyes can display intracellular fluorescence after non‐invasive uptake within injured immune effector populations.

Collaborative studies between our laboratory and the Chemistry Department (Sensors Programs) have resulted in the manipulation of fluorescent technology to develop multiple classes of fluorescent cyanine dye‐based microsensor constructs (CDBMC). In preliminary studies, these constructs have demonstrated the ability to undergo intracellular uptake and correlate cytotoxicity with fluorescent intensity. Accordingly, the current investigation was designed to determine if a modified cyanine construct could undergo intracellular uptake, correlate fluorescent intensity with cytotoxicity, and induce cytotoxicity within transformed cell lines and indicate the degree of carcinogenic lethality. Cells were incubated with the CDBMC (20 um) for 6‐24 hours. After this incubation, the treated cell cultures were collected and analyzed for cytotoxicity, lethality, cellular activity and intracellular fluorescence. The results indicated that the modified constructs altered the normal activity of the transformed cell populations and exhibited correlated intracellular fluorescence. Supported by DOE‐ER63580, NSF‐RISE HRD‐ 0627276

4:30 PM – 4:45 “A Novel Method For Separation Of Globular Proteins By Use Of Polyacrylamide Gel Electrophoresis” PM Monica R. Sylvain*1, Emily Villar1, Sayo O. Fakayode2, Jessica Lee3, Bilal El‐Zahab1, Mark Lowry1, Jack N. Losso4, Isiah M. Warner1

1Department of Chemistry, Louisiana State University, Baton Rouge, LA 2Department of Chemistry, Winston‐Salem State University, Winston Salem, NC 3Department of Chemistry, Princeton University, Princeton, NJ 4Department of Food Science, Louisiana State University, Baton Rouge, LA

Abstract Plaque formation, particularly the deposition of glycoproteins, cholesterol and cholesterol esters in coronary arteries has been shown to be associated with the onset of cardiovascular disease. Identifying the proteome of the plaque requires not only the identification of these complex protein systems but also an understanding of their modifications and interactions. As a preparative analytical tool, sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS‐PAGE) has been central to the critical work in this area. In this study, a novel variation of SDS‐PAGE has been developed, which may have great utility for the characterization of plaque associated with heart disease. Results from the mass separation of model proteins using this method will be discussed.

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4:45 PM – 5:00 PM

“Human Papilloma Virus (HPV): How Much Do We Know?”

Filomena Califano

Chemistry and Physics Department, St. Francis College, Brooklyn Heights, NY

Abstract Genital HPV infection is a sexually transmitted disease (STD) that is caused by human papillomavirus (HPV). Human papillomavirus is the name of a group of viruses that includes more than 100 different strains or types. More than 30 of these viruses are sexually transmitted, and they can infect the genital area of men and women.

Approximately 20 million people are currently infected with HPV. At least 50 percent of sexually active men and women acquire genital HPV infection at some point in their lives.

By age 50, at least 80 percent of women will have acquired genital HPV infection. About 6.2 million Americans get a new genital HPV infection each year. Most people who have a genital HPV infection do not know they are infected. The virus lives in the skin or mucous membranes and usually causes no symptoms. Some women get visible genital warts, or have pre‐cancerous changes in the cervix. Most women are diagnosed with HPV on the basis of abnormal Pap tests. There is no ʺcureʺ for HPV infection, although in most women the infection goes away on its own. The treatments provided are directed to the changes in the skin or mucous membrane caused by HPV infection, such as warts and pre‐cancerous changes in the cervix. The purpose of this research is to understand how people can reduce their risk for genital HPV infection and cervical cancer detection and prevention.

Recently, the author has been involved in studies regarding the natural history of incident HPV infection in young women, the effect of HIV infection on development anal neoplasia in men and cervical neoplasia and cancer in women, development of biomarkers for early detection of cervical cancer in women, the association of HPV with skin cancer, and the first evaluations of HPV vaccines.

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Thursday, PM Session Chair

3:00 PM – 3:30 PM

Technical Session 17

3:00 PM – 5:00 PM Room 414 Materials and Polymer Chemistry Thomas Epps Department of Chemical Engineering, University of Delaware Presenters

“Combinatorial Studies Of Surface Interactions In Block Copolymer Thin Films”

Thomas H. Epps, III*, Julie N. Lawson, Thomas P. Scherr University of Delaware, Department of Chemical Engineering, Newark, DE

Abstract As future technological progress necessitates the design and control of smaller devices for electronic and biological applications, new methods for the facile templating of nanoscale features must be discovered. To employ block copolymers for these templating applications, it is essential to understand how the interfacial interactions originating from the substrate and free surface in ultrathin (~nm) films affect diblock and triblock copolymer morphologies. Surface energetics and film thickness, which are not influential in bulk behavior, play an important role in polymer thin film structure formation. Because the majority of potential applications (e.g., membranes and nanotemplating) employ block copolymers as thin films, the interplay between bulk ordering phenomena and thin film effects must be understood. We manipulate polymer thin film interfacial interactions using combinatorial methods (solvent vapor gradients) to control the free surface interactions, and gradient arrays of assembled monolayers to influence the substrate surface interactions. These combinatorial, or high throughput, techniques allow us to quickly generate libraries of data useful for exploring the interactions between block copolymers and surfaces.

“Efficient Synthesis Of Regioregular Polythiophene Block Copolymers”

Malika Jeffries‐EL, Michael Mitchell and Robyn Laskowski.

Department of Chemistry, Iowa State University, Ames, IA

Abstract The morphology of conjugated polymers plays a significant role in the optical and electronic properties of conjugated polymers. One way to fine‐tune the morphology of conjugated polymers is to incorporate them with coil‐type polymers, forming rod‐coil block‐copolymers. Due to the immiscibility of the covalently connected segments, 3:20 PM – 3:40 PM

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TECHNICAL ABSTRACTS polymers of this type are expected to phase segregate into regimes resulting in the formation of different morphologies, such as lamella, spherical, cylindrical, and vesicular structures. By tailoring the composition of such block copolymers we can control the morphology obtained. We are currently exploring a new method for synthesis of regioregular polythiophene copolymers by coupling of appropriately functionalized polymers using “click” chemistry. The major advantage of this method is that it will allow for the rapid generation of a variety of block copolymers allowing for a detailed study of their properties.

3:40 PM – 3:55 “Surface Characterization Of Poly Methyl Methacrylate Microfluidic Channels” PM

Talitha Hampton1 and Emanuel Waddell*2

Departments of 1Chemical Engineering and 2Chemistry, The University of Alabama in Huntsville , Huntsville, AL

Abstract This work investigates electrochemical microfluidic flow through a cylindrical microchannel fabricated in Poly (methyl methacrylate) (PMMA). The surface was modified using 222 nm ultraviolet (UV) irradiation. The electroosmotic flow characteristics with non‐homogeneous zeta potentials were investigated to develop electroosmotic velocity profiles as a function of UV‐modification. Infrared spectroscopic results reveal that exposure of the PMMA surface to UV‐irradiation renders the surface hydrophilic by formation of hydroxyl groups. These results are supported by contact angle goniometry and electroosmotic velocity profile measurements which indicate improved wettability and higher electroosmotic flow.

Break 3:55 PM – 4:05 PM

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TECHNICAL ABSTRACTS “INVESTIGATION Of The Dynamic Melt Rheology And Glass Transition Temperature Of GRC‐A Loaded With Zeolite L”

T. Renee Brown1, Donald Hylton1, Eric A. Mintz1*, Conrad Ingram1, Joel Batson 1, 4:05 PM – 4:20 PM

Candace James1 and Kathy C. Chuang2 1Center for High Performance Polymers and Composites and Department of Chemistry, Clark Atlanta University, Atlanta, GA 2NASA Glenn Research Center, Cleveland, OH

Abstract Phenylethynyl terminated imides (PETI) are high temperature, high performance matrix resins that can be processed into composites by various methods including resin transfer molding (RTM). Nanostructured zeolites having uniform pore sizes with rigid pore structures are a particularly interesting additive to examine to prepare nanostructured composites. Zeolite L is a nanoporous aluminosilicate, and contains straight channels with few intersections. In this study we have examined the effect of incorporation of increasing loadings of zeolite L into GRC‐A, a PETI resin, via dynamic melt rheology, and differential scanning calorimetry, resulting in an understanding of the influence on cure kinetics, viscosity, and glass transition temperature. The results of this study will be described.

4:20 PM – 4:35 PM

“Investigation Of The Physical Properties Of The Hybrid Hydroxyethyl Acrylate/Epoxide System For Controlled Physical Properties”

Leroy Magowod, Jr*, Chris Coretsopoulos, and Alec Scranton

University of Iowa, Department of Chemical and Biochemical Engineering Iowa City, Iowa Abstract In recent years, hybrid free radical/ cationic photoinitiation systems studies have been studied because of potential applications in optics, microfluidics and other applications where precision aids in optimizing performance. Due to the combination of the unique abilities the hybrid system to be sequentially polymerized and its incorporation of both free radial and cationic active centers these systems offer a possible means to quickly and efficiently fabricate novel devices while minimizing common imperfections that may occur by current fabrication processes. By using a single illumination source, which may initiate is the visible or ultra violent region of the electromagnetic spectrum or by a thermal mechanism depending on the formulated system; the hybrid free radical/ cationic 171

TECHNICAL ABSTRACTS initiation system offers a greater degree of freedom in the temporal regions of polymerization. Also, the sequencing of the hybrid systems, best described by three distinct phases: phase 1 is a liquid, phase 2 is gel, and the final phase is a solid polymer, are examined to determine physical parameters of each phase and how they control the final polymer properties. The use of hydroxyethyl methacrylate (HEMA)/Epoxide system to create a system where the end user is capable of controlling and predicting the final polymer property was investigated. Currently we are evaluating these physical properties to determine limiting factors that may affect the final polymer with particular interest placed on stage 2 properties and how we can alter some of these factors to aid in certain applications.

4:35 PM – 4:50 “Thermal And Mechanical Characterization Of Foam Core Containing PM POSS / Expandable Thermoplastic Microspheres”

Wanda D. Jones, Vijaya K. Rangari*, and Shaik Jeelani Tuskegee University Center for Advanced Materials (T‐CAM), Tuskegee, AL

Abstract Polyhedral oligomeric silsesquioxanes (POSS) is a new class of lightweight, high performance hybrid nanomaterials. Covalently attached POSS to polymer chains has resulted in polymers with higher glass transition temperatures (Tg) as well as increased hardness, toughness, fire retardance, and corrosion inhibition. In this work, a novel sonochemical method has been developed to coat POSS nanoparticles onto expandable thermoplastic macrospheres. The POSS infused expancel polymer is fabricated into a foam core panel using an MTP‐14 programmable compression molding by heating to 190 oC for 15 minutes under a pressure of 15000 lbs. Morphological investigation of the coated microspheres have been done using scanning electron microscopy (SEM). Thermal characterization was carried out on the prepared foam using Dynamic Mechanical Analysis (DMA), Thermogravimetric analysis (TGA), and Differential Scanning Calorimetry (DSC) to determine storage modulus, decomposition temperature, and glass transition temperature of these materials. Mechanical evaluations uch as Quasi‐static compression and flexural tests have also been carried out for the nanophased foam.

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Wednesday, PM

NOBCChE Scientific Exchange Poster Session 5:00 – 7:00 PM

Franklin A

Posters (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation

“Ruthenium Oxide/Silica Composites As Novel Platform For 1 Carbon Monoxide Gas Sensing”

Adedunni D Adeyemo*1, Prabir K Dutta1

The Ohio State University, Department of Chemistry, Columbus, OH Abstract A carbon monoxide sensor has been developed based on RuO2 thin films. The bulk catalytic ability of RuO2 for CO oxidation is exploited for gas sensing. The electronic conductivity of RuO2 was tuned by mixing with SiO2. XRD confirmed the presence of crystalline RuO2 and SEM shows the surface roughness and film‐substrate contact efficiency. Film deposition technique involved proper ink composition and spin coating. Percolation theory is used as a model to describe how the conductivity is tuned. Presented in this work are sensing properties of ruthenium oxide at 200oC in the presence of CO gas in dry and humid conditions and a sensing mechanism is proposed.

2

“Ostwald Ripening at the Single Droplet Level”

Malcolm Mathis Department of Chemistry, Kent State University, Kent Ohio

Abstract A study has been performed of Ostwald Ripening at the single droplet level of alkane‐in‐water emulsions. Our Laser Tweezers instrument has the unique capability of trapping an individual droplet, whose diameter ranges from tens of nanometers to micrometer size, at the focus of a 1064 nm near IR (NIR) laser. We can observe the shrinking/growing of the droplet with time.

Currently, Dynamic Light Scattering (DLS) is the premiere method for Ostwald Ripening analysis. DLS measures the growth of the bulk level average radius of small droplets. However, a major limitation of DLS is that it cannot measure the shrinking of large droplets due to the interference of signal from the big droplets. Our Laser Tweezers instrument complements DLS. The Laser Tweezers can trap a single droplet and observe the shrinkage. The single droplet

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shrinkage results obtained by our Laser Tweezers can be directly correlated with the droplet growth results obtained by DLS to produce substantial support for the theoretical evaluation of the fundamental concepts of Ostwald Ripening. The present work will provide validation for the actual mechanism behind Ostwald Ripening at the single droplet level, for the first time, using the Laser Tweezers.

“Optimization of Lignin Degradation Components by Capillary 3 Electrophoresis‐Mass Spectrometry”

Roderquita K. Moore1,2, William Bragg3, Cass Parker1, Shahab A. Shamsi3*

1Department of Chemistry, Clark Atlanta University, Atlanta, GA 2USDA Forest Service, Forest Products Laboratory, Madison, WI 3Department of Chemistry, Center of Biotechnology and Drug Design Georgia State University, Atlanta, GA

Abstract Lignin is the second most abundant organic substance on earth, after cellulose, and plays a central role in the natural ecological cycle of plants. The lignin macromolecule is comprised of a number of ether and carbon‐linked methoxyphenols. Due to the complexity of the lignin sample, Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) seems to be an ideal technique for the analysis of charged and uncharged components of lignin. Thirty‐Five lignin standards were used to investigate the optimization of CE‐MS conditions. The optimized CZE‐ESI‐MS conditions were mobile phase containing 20mM Ammonium Carbonate, pH 9.5; sheath liquid containing 80/20 MeOH/H2O delivered at 5 L/min; spray chamber set to drying gas flow of 5 ml/min, nebulizer pressure of 5 psi, and drying gas temperature of 150 oC. Further studies are underway to analyze lignin via micellar electrokinetic chromatography (MEKC) coupled to MS, using molecular micelles. After optimizing the peak capacity of lignin standards, the method will be applied for the identification of lignin in sour orange tree.

4

“Carbohydrate Structural Determination Using Mass Spectrometry”

Aleeta M. Powe University of Louisville, Louisville, KY

Abstract Carbohydrates (saccharides, sugars) are a critical component of many proteins and until recently, have been virtually ignored in the scientific world because sensitive analytical procedures to study their structures were not available. Because of advances in mass spectrometry, information about the roles of carbohydrates in cellular processes is emerging. Carbohydrates act on a multicellular level, at the interface between cells, tissues and organs, to coordinate biological processes. They are crucial in varied activities such as development, recognition, discrimination and interactions, tissue differentiation, cell 174

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regulation and cell death. Thus carbohydrate structure elucidation is pivotal to the understanding of these processes not only in normal cells but also in those undergoing, for example, uncontrolled proliferation, as in tumor cells. This work reports beginning structural research on carbohydrate standards using a Fourier transform ion cyclotron resonance mass spectrometer (FT‐MS). Structural analysis of mono‐, di‐, and tri‐saccharides is reported.

Neat saccharides in 50%methanol/water solution fragmented in characteristic patterns with the loss of several molecules of water before further degradation. Permethylated saccharides yielded less complicated mass spectrum with characteristic losses of methyl and methylene groups. Unique fragmentation patterns permitted the elucidation of specific carbohydrate structures.

Results from this work will help in further development and optimization of mass spectroscopic and molecular biology methodologies to analyze the carbohydrate portion of specific cellular glycoproteins, and to identify subsequent glycosylation sites.

5 “Application Of Ratiometric Spectral Properties Of Salicylidene Derivatives In The Analysis Of Selected Anions” Dharendra Thapa, Richard Williams* Morgan State University, Chemistry Department , Baltimore, MD Abstract Three derivatives of the salicylidene family have been investigated as chemical sensors of fluoride and similar ions. Their absorbance and fluorescence properties were observed in the presence of varying concentrations of fluorine in order to identify wavelengths that could effectively be utilized in the ratiometric analysis of selected anions. The spectral data obtained supports a two‐step deprotonation mechanism as reported for similar compounds in previous literature. In this study, both absorbance and fluorescence ratiometric analyses of the selected salicylidene derivatives were used to determine various concentrations of fluorine, acetate, and phosphate anions. Supported by DOE DE‐FG02 ER63580 and NSF HRD‐0627276.

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POSTER ABSTRACTS 6 “Mediator‐Less Amperometric Biosensors For Phenols Based On Immobilized Tyrosinase In Chitosan Film”

Yanique Thomas, Dr. Yongchao Zhang*

Morgan State University, Chemistry Department, Baltimore, MD

Abstract

We studied different methods of making amperometric biosensors for phenols by immobilizing mushroom tyrosinase in the biocompatible polysaccharide chitosan matrix. At pH 6 chitosan exists as polycations and forms strong electrostatic adduct with tyrosinase which is polyanionic (pI 4.5-5), and thus strongly immobilizes the enzyme. The use of cross-linkers to enhance the immobilization was also examined. Phenols such as tyrosine were oxidized by oxygen catalyzed by the immobilized tyrosinase, and the product o-quinone was directly reduced at the electrode at -0.05 V vs Ag/AgCl, thus generating an electroreduction current which was used to quantify the phenols.

7 “Evaluation Of The Precision And Accuracy Of Laser Ablation ICP‐MS As A Rapid Method For Trace Element Analysis Of Modern Sediments”

1 * Marvourneen K. Dolor , William F. McDonough2 and George R. Helz1, 2

1Department of Chemistry and Biochemistry, 2Department of Geology University of Maryland, College Park MD

Abstract

Numerous studies have documented profound anthropogenic influences on trace element profiles in dated sediments from estuaries. However, the vast majority of these studies focus on a small number of relatively high‐abundance of trace elements, (e.g. Ni, Cu, Zn, Cd and Pb).

A high‐throughput analytical method that greatly extends this list would be useful. Laser Ablation – Inductively Coupled Plasma – Mass Spectrometry is a promising candidate with unique advantages: time and labor expended on sample preparation are minimized and risks of contamination by reagents are eliminated.

The goal of this work was to evaluate whether Laser Ablation‐Inductively Coupled Plasma‐ Mass Spectrometry (LA‐ICP‐MS) is an accurate and precise method for exploring the behavior of a suite of metals in Chesapeake Bay cores. From the first report of LA‐ICP‐MS (Gray, 1985) the main challenge has been obtaining accurate quantitative analyses. This is due to the lack of suitable accurately known internal standards, sparse availability of certified standards and the difficulty of obtaining matrix‐matched standards (Cromwell and Arrowsmith, 1995; Eggins, 176

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8

2003). Matrix‐matched standards are particularly important in LA‐ICP‐MS because the ablation yield varies with the physical properties of the materials being analyzed. These properties include melting and boiling points, reflectivity and thermal conductivity (Hoffmann et al., 2002). In this work I used both matrix matched standards (MAG‐1 and SCo‐1) and a certified standard from NIST (NIST 610). We found that it is possible to apply LA‐ICP‐MS to the analysis of sediments with a large age range, in order to obtain accurate and precise measurements of the concentrations of the following elements: S, CaO, V, Mn, Fe, Ag, Co, Cu, Ge, As, Se, Nb, In, Sn, Sb, Te, W, Tl, Pb, Bi and U.

Cromwell E. F. and Arrowsmith P. (1995) Semiquantitative Analysis with Laser‐Ablation Inductively‐Coupled Plasma‐Mass Spectrometry. Analytical Chemistry 67(1), 131‐138.

Eggins S. M. (2003) Laser ablation ICP‐MS analysis of geological materials prepared as lithium borate glasses. Geostandards Newsletter‐the Journal of Geostandards and Geoanalysis 27(2), 147‐162.

Gray A. L. (1985) Solid Sample Introduction by Laser Ablation for Inductively Coupled Plasma Source‐Mass Spectrometry. Analyst 110(5), 551‐556.

Hoffmann E., Ludke C., Skole J., Stephanowitz H., Wollbrandt J., and Becker W. (2002) New methodical and instrumental developments in laser ablation inductively coupled plasma mass spectrometry. Spectrochimica Acta Part B‐Atomic Spectroscopy 57(10), 1535‐1545.

“Optical Sensors For The Selective Detection Of Organophosphorus Pesticides”

1 2 Tova A. Samuels , Chandrima De , Desmond H. Murray3, and Sherine O. Obare*4

1University of North Carolina at Charlotte, Department of Chemistry, Charlotte, NC 2Department of Chemistry, Western Michigan University, Kalamazoo, MI 3Department of Chemistry and Biochemistry, Andrews University, Berrien Springs, MI 4University of North Carolina at Charlotte, Department of Chemistry and the Nanoscale Science PhD Program, Charlotte, NC

Abstract

In the US, over 100 organophosphate (OP) pesticides are used in the agricultural industry.

These pesticides contaminate air, water, soil, and produce, thus presenting toxicological concerns. When OP pesticides are absorbed via ingestion, skin penetration and inhalation, the availability of acetylcholinesterase enzyme (AChE) at nerve endings is depleted. As a 177

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result, nerve impulse transmission control is disrupted. Therefore, there is a major need to develop selective sensor for the detection and discrimination of organophosphorus pesticides. The creation of new materials for sensing and actuation requires careful manipulation of the responsive units required to control analyte selectivity. We have developed a series of fluorescent molecular sensors based on substituted aza‐stilbenes.

Rational choice of substituents allows manipulation of the optical, electrochemical and mechanical properties required to selectively distinguish between various toxic organophosphorus‐based pesticides. We have demonstrated that the aza‐stilbenes show significant differences in the optical and electrochemical signal outputs upon interaction with various organophosphorus pesticides. The presentation will demonstrate the rational choices in substituent selection for selective discrimination between organophosphorus compounds.

9

“Cyanine Sensors Monitor The Degree Of Flavinoid Protection Against Endotoxin‐Induced Fetotoxicity”

Evelyn Ntam, Tricia Charles, Roxanne Howell, Michael Baker, Carroll Reese, Tanika Martin and Dwayne Hill*

Morgan State University, Department of Biology, Baltimore, MD

Abstract

Endotoxins have been well documented for their adverse effects on fetal development.

Studies have indicated that immune‐effector cell activity is causal for endotoxin induced cytotoxicity. Thus, it is conceivable that decreases in effector‐cell activity could alter the degree of endotoxin‐induced cellular or tissue damage. Natural flavinoid extracts (e.g. silymarin) can decrease immune‐cell activity; however, the feto‐protective activity of flavinoid extracts requires further investigation. To determine the degree of injury or protection with significant specificity, the near infrared fluorescence of cyanine dyes will be applied. Therefore, the present study was designed to address the hypothesis that in utero pretreatment with silymarin affords protection against endotoxin induced fetotoxity, in addition, cyanines can help to bio‐sense the degree of fetal injury. Pregnant rats were pretreated with silymarin (gestation days 7–17) and exposure to endotoxin occurred from days 12‐17. On day 18, cyanine sensors were applied in utero and post utero to indicate the degree of injury to fetal tissues. Parameters of fetotoxicity were extended from fetal weight to tissue injury. The results demonstrated that pretreatment with flavinoid extracts afforded protection against endotoxin‐induced lethality and the level of injury was bio‐ sensed. Supported by DOE DE‐FG02 ER63580 and NSF HRD‐0627276.

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“An Investigation Of The Use Of Chitosan As A Substitute For 3‐(Amino‐Propyl) Triethoxysilane (Aps) In The Fabrication Of Glass Surfaces For Use As Substrates In Metal Enhanced Fluorescence Techniques” Ichhuk Karki*, Richard Williams Morgan State University, Department of Chemistry, Baltimore, MD Abstract Metal Enhanced Fluorescence is a promising analytical technique that offers several advantages in overall detection sensitivity. The current preparation on a glass surface calls for a time consuming and corrosive silanization step before the application of APS as a precursor for the deposition of silver onto the glass substrate. Chitosan is a relatively inexpensive and readily available biopolymer that contains amino groups that allow it to form stable complexes with silver metal. In this investigation, Chitosan is examined as a substitute for the silanization step in the deposition of silver on a glass substrate.

Comparisons of metal enhanced fluorescence prepared the conventional way and with Chitosan are presented. Supported by DOE ER 63580 and NSF HRD‐0627276.

11

“Prospective Usefulness Of Cyanine Sensors To Indicate If PCB‐Challenged Progenitor Cells Can Produce Regulatory Factors For Macrophages”

Oluwafadekemi Adedayo, Courtney Fields, Tanika V. Martin, Carroll Reese, Dwayne Hill*

Morgan State University, Department of Biology, Baltimore, Maryland

Abstract

Progenitor cells (PCs), such as neural crest cells, are essential precursors for many developmental structures. They are a highly migratory population of differentiating cells that are sensitive to toxic insults. The mechanisms that mediate PC toxicity are not fully understood. In addition, pool of available fluorescent indicators that sense the degree of immune cell‐mediated injury and cytotoxicities is not extensive. Inflammatory cells (e.g. macrophages) play a role in the mechanisms of various toxicities. Our recent data has suggested that conditioned medium collected from PCs exposed to a single dose of polychlorinated biphenyls (PCBs) is chemotactic for macrophages; this activity may be monitored by fluorescence. Accordingly, the present study will be designed to determine if PCBs, in a dose/time dependent manner, cause PCs to release a factor(s) that regulates macrophage activity and if this activity could be sensed using fluorescent cyanines. To conduct this study, PC cultures will be treated with various doses of the PCB mixtures, and incubated. The resulting PC‐derived conditioned media (PC‐CM) will be collected. The

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12

ability of PC‐CM to induce various parameters of macrophage activation will be analyzed.

In addition, a correlation between the degree of macrophage activation/cytotoxicity and specific fluorescent cyanine uptake/intensity will be determined. The collected PC‐CM stimulated macrophage activation and this activation was monitored via spectrophotometric analysis. Supported by DOE ER63580, NSF‐RISE‐ HRD 0627276.

“The Preliminary Characterization Of Environmental Estrogens In Wastewater Effluents”

1 2 Reba L. Scott* , Katoria Tatum‐Gibbs , Dr. Tuan Phan3, Dr. Renard L.Thomas3, Dr. Bobby Wilson3

1 Space Engineering, & Science Internship Program, Texas Southern University, Houston, TX 2 Environmental Toxicology PhD. Program, Texas Southern University, Houston, TX 3 NASA University Research Center, Texas Southern University, Houston, TX

Abstract In this study, the objective is to identify estrogens in sewage effluents. Estrogens are a group of steroid compounds that function as the primary female sex hormone. Estrogens are used as oral contraceptives and estrogen replacement therapy in postmenopausal women. Sewage effluents may contain many different estrogens, including estrogens that are endocrine disrupting compounds (ECDs). ECDs are both natural and man‐made and they can interfere with the endocrine glands and their hormones that alter the functioning of the endocrine system. It is important to identify theses estrogens to have a better understanding of the effects of theses estrogens in the environment. The procedure includes a solid‐phase extraction (SPE) of approximately 500 milliliters of water samples.

The SPE absorbent used for sample preparation was an octadecyl (C18)‐bonded silica sorbent. High Performance Liquid Chromatography with ultraviolet detector (HPLC ‐ UV) was used to characterize the estrogens in the sewage effluents. HPLC ‐ UV was used for its specific detection and potential identification of estrogens in the presence of other chemicals. The preliminary analysis showed the presence of three compounds at levels between .0206 mgL‐1 (estradiol) to .2257(ethinyl estradiol) mgL‐1. The EPA does not regulate the levels of estrogens that are released into the water, but even at low concentration levels the estrogens have been observed harmful on the reproduction, growth, and development of certain species of wildlife [4, 5].

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“Alteration Of Neoplastic Cell Homeostasis By Cyanine Derivatives”

1 1 Tolulope Ayangade , Phillip Butler , Michael Baker1, Colette Ntam1, Nicole Flemming2, Nikia Smith2, Devine Kebulu2, Angela Winstead2, Deshauna Curry2, Richard Williams2, Laundetta Jones3 and Dwayne Hill*1

Departments of Biology1 and Chemistry2, Morgan State University, Baltimore, Maryland, Department of Pharmacology and Experimental Therapeutics3, University of Maryland, Baltimore, Maryland

Abstract

Macrophages are immune effectors, of monocyte lineage, that are critical for the protective activities induced by adaptive and innate immunity. Epithelial cells comprise the majority of organ tissue parenchyma and are essential for normal organ system function. It has been documented that certain environmental pollutants can cause these cell populations to transform into malignant neoplasms. If this transformation occurs, normal immune and organ system function could be compromised and the development of severe carcinogenic events could result such as monocytic leukemia and/or breast epithelial carcinoma. Efforts to treat and/or prevent the development of these cancers have been encouraging, however clinicians and researchers are still interested in using new and more specific applications to target the transformed cell populations and indicate the level of neoplastic destruction.

Studies have shown that cyanine dyes can undergo fluorescence after un‐harmful uptake within compromised macrophage cell cultures. Recent collaborative studies with the department of chemistry (Sensors Program) have suggested that modification of the base cyanines may result in fluorescence and lethality in certain transformed cell populations.

Thus, the current study was designed to determine if the modified cyanine dye based microsensor constructs (CDBMC) can induce cytotoxicity within transformed epithelial cells and macrophages. In addition, this study will help determine if these cyanines exhibit intracellular fluorescence that correlates with the level of cytotoxicity. Cells were incubated with the constructs (20 um) for 6‐24 hours. After this incubation, the treated cell cultures were collected and analyzed for cytotoxicity, lethality, cellular activity and intracellular fluorescence. The results indicated that cyanine constructs altered the normal activity of the transformed cell populations and intracellular fluorescence of CDBMC was observed. Supported by DOE‐ER63580, NSF‐RISE HRD‐0627276

181

POSTER ABSTRACTS “Quantifying Inorganic Contaminants In The Municipal Drinking Water Using ICP‐ MS”

Uchenna Obianagu1 , Andrea Oyewole2 , Felicia L. Conley3 , Renard L. Thomas3 , and

14

Bobby L. Wilson3

1. Space, Engineering, & Science Internship Program, Texas Southern University, Houston, TX 2. Environmental Toxicology Ph.D. Program, Texas Southern University, Houston, TX 3. NASA University Research Center, Texas Southern University, Houston, TX

Abstract

The municipal district supplies drinking water to a large number of the greater Houston area. A comprehensive study was conducted to identify trace metals, along with their level of abundance, within the water and compare them to EPA maximum contaminant levels.

Our major concern was with the primary contaminants, but tests were also conducted for secondary contaminants as well. Trace metal contaminated water samples were collected from eight local fire stations and quantified in accordance to EPA method 200.8 version 5.4.

Each fire station was visited twice and 2 samples were collected from each site. During analysis, each sample was run twice to give a total of 32 samples per analysis. For secondary contaminants, the results showed that some fire stations exceeded standards for sodium and iron. For primary contaminants, some fire stations exceeded set levels for copper and lead. Although sodium and aluminum are not primary contaminants, their levels well surpassed the maximum contaminant levels and therefore maybe be a cause for concern. Lead is a primary contaminant and is considered hazardous at any level. Proper measures should be taken to make sure that municipal drinking water in areas tested meet the EPA standard levels.

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“Covalent Incorporation Of Imidazo[1,5‐A]Pyridine In Sol‐Gel Matrices And Their Application As Potential Chelating Ligands” Anastesia S. Lyons1, Roger Rowell2, Xiu Ren Bu*1 1Clark Atlanta University, Department of Chemistry, Atlanta, GA 2United States Department of Agriculture Forest Services, Madison, WI

Abstract Hybrid materials are formed having a homogeneous distribution of an imidazo[1,5‐ a]pyridine monomer and an inorganic matrix. The imidazo[1,5‐a]pyridine scaffold was reacted with 3‐isocyanatopropyltriethoxysilane (3‐ICPS) to form a functionalized silicon alkoxide precursor. A sol‐gel monolith with the imidazo[1,5‐a] pyridine covalently incorporated at different concentrations was prepared via the copolymerization of tetraethyl orthosilicate (TEOS)/ tetramethyl orthosilicate (TMOS) and the previously synthesized functional silicon alkoxide precursor in a H2O/CH3COOH/C2H5OH solution.

The inorganic‐organic hybrid was characterized via Fourier Transform Infrared Spectroscopy, Thermogravitimetric Analysis, and 13C Nuclear Magnetic Resonance. In addition, surface area, pore size, and possible application were explored.

16

“Synthesis And Application Of Redox Gradient Relay Molecules” Melody Kelley, Silas Blackstock* The University of Alabama, Department of Chemistry, Tuscaloosa, Al Abstract One of the more recent inventions in the area of renewable energy has been that of the Dye Sensitized Solar Cell (DSSC) by Michael Grätzel. The DSSC presents a low cost alternative to solid state devices that convert sunlight to electricity. My research is aimed at i mproving overall efficiency of the device. One process that hinders the efficiency of the cell is charge recombination in the dye after photon absorption. Efficient charge separation upon excitation is necessary for efficient light to electrical energy conversion to beachieved.

We are preparing a group of redox relay molecules intended to prevent charge recombination at the dye/semi‐conductor interface. As Figure 1 demonstrates, the relay will be attached to the light harvesting dye and will carry the electron hole or positive charge away from the site of injection. The relay consists of amine groups are varied so that redox potentials are coordinated to move positive charge away from the dye and semicon‐ ductor. The end of the relay will is designed to store multiple charges and thus can rapidly return the active dye to its ground state thereby improving the overall efficiency of the cell.

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The structure, synthesis, electrochemical properties and application of the redox gradient relays will be presented.

17

“Synthesis And Characterization Of PTV‐Based Donor Polymers”

Tanya David*, Cheng Zhang, Sam Sun, Rui Li

Norfolk State University, Center for Materials Research Norfolk, VA

Abstract

Renewable energy that is cost efficient and a potential solution to several critical concerns in today’s society is a hot topic in the scientific world today. Polymer materials are processible, lightweight, and cost efficient. The part of the solar spectrum that our solar cells would like to make full use of is the near Ultraviolet (blue ~2.6eV) to the near Infrared (Red >0.5eV). To accomplish this, tandem cells which are a series of solar cells will be fabricated with several different polymer materials each capable of absorbing a different portion of the solar spectrum (i.e. one material to absorb in the blue range, one for the yellow and one for the red). Therefore the appropriate high band‐gap to low band‐gap (<2eV to 0.5eV), soluble and easily fabricated donor and acceptor polymers are required.

This research focused on the development of polythienylenevinylene‐based donor and acceptor polymers. Monomer and polymer synthesis and characterization using various methods such as GPC, UV‐Visible Spectroscopy, Florescence, NMR, DSC, and TGA, will be presented.

“Synthesis And Photophysical Characterization Of Schiff Bases 18 As Anion Sensors”

Belygona Barare, Dr Yousef Hijji* Morgan State University, Department of Chemistry, Baltimore MD Abstract

A series of salicylaldimines were synthesized from condensation of salicyaldehyde and aryl amines without solvent under irradiation from a conventional microwave oven. The microwave mediated condensation allowed for the synthesis of Schiff‐bases in good to

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excellent overall yields in short reaction times. The Schiff‐bases were purified by recrystallization and confirmed by 1H‐NMR, 13C‐NMR, IR, GC‐MS and X‐ray crystallography.

The Schiff bases were studied as anion binding sensors. These sensors comprise of two parts; one is the anion binding part which is based on amine and phenol moieties. The other is a conjugated chromophore which converts binding induced changes into an optical signal detected visually or by a UV‐vis spectrophotometer.

Substantial bathochromic shift and well defined color change in the visible region of the spectrum was observed upon addition of fluoride, dihydrogenphosphate and acetate ions.

Addition of chloride, bromide, perchlorate and hydrogen sulphate did not result in appreciable change in color. Significant bathochromic shift of the absorption maxima and color changes in the visible region are presumably due to the formation of hydrogen bond and interactions between the anions and the phenol protons of the sensors.

Titration experiments of the receptors with various concentrations of the anions showed high selectivity to acetate, then fluoride and dihydrogenphosphate with corresponding binding constants. The anion to sensor ratio showed to be 1:1 for all anions detected.

Addition of protic solvents as water or ethanol caused the color of the solution to disappear, indicating that proton transfer is the mechanism of action of these sensors.

The results of these studies and potential application of these sensors will be presented.

Supported by DOE DE‐FG02 ER63580 and NSF HRD‐0627276.

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“Novel Porphyrin Tweezers For Absolute Stereochemical Determination Of Chiral Molecules” Dalila Davis*, Babak Borhan, Marina Tanasova Department of Chemistry, Michigan State University East Lansing, MI

Abstract Tetrahedral geometry of a carbon atom provides such a term as chirality. Chirality indicates spatial arrangement of the substituents at the carbon. For instance two carboxylic acids presented below, have similar structures, but possess an opposite chirality.

Determination of chirality is crucial thus all natural products (proteins, carbohydrates, hormones, amino acids, vitamins and a variety of natural compounds) exhibit optical activity.

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One of the methods developed for determination of absolute stereochemistry uses chromophores as chiral receptors. The method is based on the ability of the chromophores to interact though space. This interaction is called Exciton Coupling. If the orientation of chromophores is chiral, it can be detected by CD spectrometer as an ECCD (exciton coupled circular dichroic) spectrum.

20

“Synthesis And Photophysical Characterization Of 2‐Hydroxylnaphtalene‐1‐yl (Methylene) Hydrazinecarboxamide As An Anion Sensor”

Oyebola A Oladeinde, Dr Yousef Hijji* Morgan State University, Department of Chemistry, Baltimore MD

Abstract In this research, novel colorimetric sensor, 2‐hydroxynaphthalene‐1‐yl (methylene) hydrazinecarboxamide 1 was synthesized in good yield by reacting 2‐ Hydroxynaphtaldehyde with semicarbazide hydrochloride, at room temperature, as shown in figure 1. The purity and structural identification of compound 1 was confirmed by 1H‐NMR and 13C‐NMR spectroscopy.

Photophysical characteristic of compound 1 at 1 x 10‐5 M concentration was studied by measuring the effect of various anions such as fluoride, acetate, dihydrogen phosphate, chloride, and bromide ions, using acetonitrile as the solvent. After the addition of the anions, only fluoride, acetate and phosphate ions produced a significant color change which was observed visually. Further testing of the sensor 1 with bromide and chloride ions did not produce any color change.

UV‐vis analysis of compound 1 showed a peak at 362nm, which shifted to 401nm after the anions were added. Addition of the fluoride ion showed a decrease in its maximum at 362nm and an increase in the peak at 401nm accompanied with a color change. The addition of the acetate and dihydrogenphosphate ions to compound 1 showed a less significant color change.

The observed results were due to varying the concentrations at which the anions were added to the compound synthesized. In conclusion, a semicarbazone compound was synthesized which is a colorimetric sensor for fluoride, acetate and phosphate ions.

Supported by DOE DE‐FG02 ER63580 and NSF HRD‐0627276.

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POSTER ABSTRACTS “Titanium Catalyzed 3‐Component Coupling & Intramolecular Asymmetric Hydroamination Of Aminoalkenes”

21

Kevin R. Gipson1, Aaron L. Odom*2, Supriyo Majumder3 Michigan State University , Department of Chemistry, East Lansing, MI Abstract Asymmetric hydroamination of amimoalkenes is an efficient and atom‐economical process to produce enantiomerically pure pyrrolidines. Pyrrolidines are important from the pharmaceutical perspective. We have synthesized a new chiral ligand by the condensation reaction between 2, 2’ diamino‐1‐1’ binapthalene and 2‐formyl‐5 mesityl pyrrole. The catalysts are made by reacting the chiral ligand with TiCl4 and also with ZrCl4. Currently we are in the process of probing the activity of these two catalysts. We are also looking at ways to generate a new cationic complex for their use in asymmetric hydroamination reaction.

3‐component coupling uses iminohydrazination methodology to couple alkynes, hydrazines, and isonitriles. We have developed a new ligand by reacting mesityl pyrrole, dimethyl amine hydrochloride, and formaldehyde. The catalyst is made by reacting the new ligand with Ti(NMe2)4. The catalyst’s activity will be tested for 3‐component coupling using mono‐substituted hydrazine.

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“Photo‐Physical Properties Of Nano‐Aggregates Of Oligomers Of MEH‐PPV”

Gizelle A. Sherwood*1, Tim Smith1, Ryan Cheng1, Linda A. Peteanu1, J. Wildeman2.

1Department of Chemistry, Carnegie Mellon University, 4400 Fifth Ave, Pittsburgh, PA 2 Zernicke Institute for Advanced Materials, University of Groningen, Nijenborgh, Netherlands

Abstract

The effects of aggregate formation on the photo‐physical properties of oligomers of MEH‐ PPV are studied in order to better understand the effects of aggregation on the emission properties of the polymer. Nano‐aggregates of oligomers from 3 to 17 repeat units in length are formed via a re‐precipitation method. Dynamic light scattering (DLS) is used to

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characterize the resulting size distributions of these nano‐aggregates. Bulk solution fluorescence reveals that these nano‐aggregates form well‐resolved electronic spectra that are not typical of the classical excitonic picture of chain‐chain interactions, that is, either H or J type aggregates or excimers. The photo‐physics of these aggregates are also highly dependent on the oligomer chain length and aggregate size. Total internal fluorescence microscopy (TIRF) is used to further characterize the solid state of these nano‐aggregates in order to determine whether or not solvent interactions play a role in the spectroscopic properties of these aggregates. The results of solid state fluorescence on single aggregates further corroborate the bulk solution fluorescence data.

23

“Physical Characterization Of Spectroscopic Methods: Mass Spectroscopy”

Steven M. Cannon

Chemistry Department ,University of Illinois at Chicago, Chicago, Illinois

Abstract

Mass spectroscopy characteristics have raised it to an outstanding position among analytical methods. It has unequal sensitivity and detection limits and the diversity of its applications among atomic physics, reaction physics, reaction kinetics ,and all forms of chemical analysis especially biomedicine and ion‐molecular reactions. There are four components to the mass spectrometer: a device to introduce the compound that is analyzed, the gas chromatograph, a source to produce ions from the sample, one or several analyzers, a detector , and a computer. Also, I would like to investigate NMR spectroscopy. As you know , molecules are inconviently too small to be observed and studied directly. Nuclear magnetic moments are equally sensitive to their surroundings.

Electron ionization leads to fragmentation of the molecular ion. Chemical ionization and proton transfer are other subjects of interest. Ion‐molecule collisions are induced in a definite part of the source.

Thermodynamics is commonly thought of as that subject which treats the transformation of energy and the accompanying changes in the states of matter. The laws of macroscopic thermodynamics clearly must arise out of many atoms and other particles. I would like to study the fundamental equations of states. Linear Transport Relations and kinetic description of dilute of gases are important. In material science, I would like to develop materials for the aging space shuttle.

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POSTER ABSTRACTS “Dielectric Monitoring Of Epoxy Resins”

Chidi S. Anyanwutaku, Dr. Alvin Kennedy*

Morgan State University, Department of Chemistry, Baltimore, MD

Abstract

As humans continue space exploration, it may become important to understand how micro gravity affects the processing of materials. This research is focused on discovering how micro gravity affects the processing of polymers particularly epoxy resins. The purpose of this research is to better understand the nature of the relationship between the dielectric spectra attained during polymerization of epoxy resins and the changes in polymer structure and morphology. In the process of achieving this goal, the dielectric properties (Dielectric loss and dielectric constant) of the epoxy resin, Epon 825, was monitored while it underwent polymerization with 3,3’‐DDS as the curing agent. Afterwards, the polymerization reaction of epon 825 with 4,4’‐DDS was also monitored similarly. The Dielectric analyzer (DEA) is the instrument that was used for this purpose. It was observed that as epoxy/amine ratio increased, there were shorter loss peak times at the different frequencies; at low frequencies there were hardly any loss peaks.The results show significant differences in the dielectric properties between the two samples while they underwent polymerization. Hence, a minor modification to the structure of the curing agent, caused a major difference in the dielectric properties as loss peak times increased when 4,4’‐DDS was used in place of 3,3’‐DDS. (Supported by HBCU‐UP Program NSF 0506066)

“Microwave Heating Of Solvents At Subambient Temperatures” 25

Emmanuel N. Dowuona, Dr. Alvin Kennedy*

Morgan State University, Department of Chemistry, Baltimore, MD

Abstract Microwave heating of cooled solvents provides a unique approach to microwave heating.

Because the solvents are heated from a temperature that is below zero, it provides information about the reaction mechanism when the solvent is heated by identifying the first step of the multiple step reaction that takes place when the solvent is heated at room temperature. In addition, using pre‐cooled solvents can allow reactions to occur that would not normally occur at room temperature. The use of cooled substances can also give more insight into the nature of the reaction that takes place by determining whether the reaction that occurs at room temperature can occur under subzero temperatures.

24

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26

Temperature profiles of several solvents that were previously cooled to temperatures below ‐30°C and heated to about 100°C were taken and compared to temperature profiles of the same solvents heated from room temperature to 100°C to determine any similarities and differences. Then, these same solvents would be pre‐cooled to a subzero temperature and heated to a room temperature in separate reactions, one using the microwave and the other involving simply allowing the solvent to reach room temperature on its own. This information, in turn, would be analyzed to determine the heating mechanisms and properties of the solvents and of microwave radiation, respectively. Supported by HBCU‐ UP NSF 0506066.

“Dynamics Of Fast Reactions In Ionic Liquids” Kandis Stubblefield1, Kathryn Sims1, Shawn M. Abernathy1, and James F. Wishart2

1Howard University, Department of Chemistry, Washington, DC 2Brookhaven National Laboratory, Upton, NY

Abstract Ionic liquids (IL’s) are novel materials consisting solely of ions, and having melting points below 100 °C. Among their many applications in technologies and green chemistry (a field dedicated to reducing the use and generation of hazardous substances) they are being considered as processing media in the advanced nuclear fuel cycles needed to support a sustainable nuclear power industry for the world’s future energy needs. It is therefore important to understand the radiation‐induced chemistry of ILs and how it may affect the chemistry of nuclear fuel separation. The unique reactivity of the “pre‐solvated” electron surfaces as an important aspect of radiation chemistry is due to the slower response to charge movement in ionic liquids relative to ordinary solvents. This study explores the reactivity of pre‐solvated electrons in the ionic liquid N‐methyl N‐butylpyrrolidinium NTf2 (P14NTf2) by measuring the kinetics of their reactions with cadmium, nitrate and selenate ions. These ions were selected because they show a wide range of reactivities with electrons in conventional solvents. The process of electron salvation, which competes with pre‐solvated electron capture, is estimated by measuring the benzophenone anion salvation process because its spectroscopic properties are better suited to the available detection equipment than those of the electron. The Brookhaven National Laboratory (BNL) Laser Electron Accelerator Facility (LEAF) was used for all of the kinetics measurements performed by pulse radiolysis transient absorption spectroscopy. The C37

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parameter is obtained parameter is obtained at a lower concentration of benzophenone.

Higher concentrations allow us to look at the spectral shift and compare it to that of the selected ions in the IL. In conclusion, we will determine the reaction kinetics of fast reactions in the IL.

27

“Effect Of Concentration Of Titanium Dioxide Scatterers In A Solid State Random Laser”

John Kibet Kitur* Norfolk State University, 700 Park Ave., Norfolk, VA Abstract Our goal in this research is to characterize the effect of titanium dioxide concentration on the transport mean free path and threshold in studying the random laser.

Using the coherent backscattering technique we are attempting to measure the transport mean free path (Lt) for titanium dioxide R‐902 which has a density of 4 g/cm^3 and its size is 0.42 micro meters at different concentrations in suspensions of the titanium dioxide scatterers in methanol.Also using rhodamine 6g die of concentration 20 g/lit we are attempting to measure the thresholds at different concentrations using a spotsize of 0.7112 mm and a slit size of 0.5 mm.

We have found a relationship between the transport mean free path and the concentration where the value decreases linearly as the concentration increases.The values of threshold increase to a certain concentration where we observed that it starts decreasing towards high concentration.

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“Fabrication Of 3d‐PPA’s Of Hexagonal Ag Pattern On The Substrate Mica Utilizing AFM & NSOM”

Eric J. Robinson*& Dr. Carl E. Bonner

Norfolk State University, Center for Materials Research, Norfolk, Virginia

Abstract

Silver nanoparticles are of important interest in our society today. In recent years, the properties of silver ( being the highest thermal and electrical conductor of the transition metals) have helped to advance breakthroughs in medical technology, materials science, electrical, and optical technology. This research delves into the nanocharacterization portion of nanotechnology. More specifically, the characterization of Silver nanoparticle films. One of the most successful techniques utilized for producing well‐ordered 2D particle arrays for Ag nanostructures is Nanosphere Lithography. The concept was first discovered from the work of Fischer & Zingsheim in 1981, who introduced “naturally”‐ assembled polystyrene latex nanospheres as a mask. The following year Deckman & co‐ workers expounded on this research, effectively demonstrating that a self‐assembled nanosphere monolayer could be used as a material deposition & etch mask. The final stage of NSL is credited to the work of Van Duyne, who developed a double layer (DL) nanosphere mask, utilized AFM as a tool for analyzing SL & DL PPAs of Ag on mica, & successful fabrication of defect‐free SL & DL PPAs of Ag, consisting of areas of 10‐100 μm2. Using a 0.5‐10 μL automatic pippeter, 2 μL of 390 & 290 nm polystyrene beads were applied & spread onto the hydrophilic slides. The slides were then placed in an oven & dried in vacuum for ~15 min. Once the slides were completely dry, SEM was used to verify the monolayer of beads. Only upon verification of a monolayer were the slides deposited with Ag using Thermal Evaporation. AFM and NSOM will be utilized to verify the properties of these Ag slides. Ultimately, the goals of this research is to test if Quantum Confinement plays a role in the optical properties of these NSL Ag films, & if so, does it offer a positive advantage over traditional (bulk) Ag films. We would also like to cross‐link alkanethiol chains (1‐Dodecanethiol) as a chemical bridge for biochemical detectors, since alkanethiol SAMs have been studied as a model system for self‐assembly.

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POSTER ABSTRACTS “Silylamides Of Ga And In For Use In The MOCVD Of Metal Nitrides”

Felicia A. McClary, Jason S. Matthews Howard University, Department of Chemistry

Abstract

29

A series of 1° amines were reacted with chlorosilanes to afford the desired silylamine. The isolated product was purified via reduced pressure distillation and subsequentially reacted with butyllithium to afford the lithium silylamide. The metathesis reaction of the lithium silylamide with chlorides of gallium and indium resulted in the formation of precursors suitable for the MOCVD growth of metal‐nitrides. The isolated products were characterized via NMR, MS, and FT‐IR. Precursor volatility was assessed via thermal gravimetric analysis (TGA).

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“Influence Of Conductive Carbon On Properties Of Solution Cast SBS‐Polyaniline Composite Films”

Yunus Balogun and R.C. Buchanan

University of Cincinnati, Dept. of Chemical and Materials Engineering, Cincinnati, OH

Abstract

Blends of poly(styrene‐co‐butadiene‐co‐styrene) (SBS) block copolymer, polyaniline (PANI) and carbon were prepared as composite materials in order to produce films with good conduction, processability and mechanical properties, within the system. Objective was to develop EMI, ESD, or sensor materials (pressure, temperature, gas) for various device applications. Since the combined SBS‐PANI system results in lower charge carrier mobility for the PANI, the role of the conducting filler carbon phase is to develop percolative conduction in the system. The PANI, prepared by in‐situ polymerization of aniline in the presence of dodecylbenzene sulfonic acid (DBSA) acting both as surfactant and dopant, was dispersed in a solution of the SBS block copolymer with toluene as solvent. The resultant solution, mixed with varying amounts of activated carbon was cast into films for structural (SEM, DSC and XRD) and thermal / electrical characterization. The SBS‐Carbon (30 w/o) showed low conduction (ρ ~2 x105 ohm‐cm) and a positive temperature coefficient behavior in the range from +20 to ~70oC. In contrast, a negative temperature coefficient behavior and lower resistivity was observed for the composite containing a 50/50 ratio of the carbon and PANI. Mechanical properties degraded with increasing amounts of PANI. The degree of crystallinity was also found to change with the carbon/PANI ratio. These data will be presented and discussed.

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32

“Polymerization Of Nanocomposites”

Abisola B. Ajayi, Dr. Alvin Kennedy*

Morgan State University, Department of Chemistry, Baltimore MD

Abstract

This research focuses on monitoring the polymerization process of epoxy resins. Epoxy resins are used in construction of aerospace equipments and vehicles. The properties that were measured include the Tg (the glass‐transition temperature), the extent of polymerization and polymerization exotherm. These properties were measured using a Differential Scanning Calorimeter (DSC) with TA Universal Analysis software. Materials that were used consist of diglycidal ether of bisphenol A (epoxy resin), 4‐ 4diamonidiphenylmethane (curing agent), and nanoclay (I.28). The main goal of this research is to increase productivity, strength, and reliability of nanocomposites. Two types of epoxy resins, Epon 825 and Epon 828, were used to obtain comparable results. Samples were prepared using stoichiometric and non‐stoichiometric ratios in order to investigate difference in properties. The stoichiometric ratio of Epon 828 to DDM is 3.8:1 and that of Epon 825 is 3.5:1. In using the stoichiometric ratios, results indicate that Epon 828 had a higher glass‐transition temperature than Epon 825. In preparing nanocomposites, a 3% and 5% quantity of nanoclay was added to the stoichiometric measures of Epon 828 and Epon 825. Results indicate that the 5% nanoclay sample would form a strong and more resilient polymer network due to its high glass‐transition temperature. Supported by LSAMP.

“The Thermal And Exfoliation Properties Of Nanocomposites And Thermosets At Different Reaction Ratios”

Racquel Jemison1, Solomon Tadesse1, Dr. Alvin P. Kennedy1*, Dr. Eugene Hoffman2

1Morgan State University, Department of Chemistry, Baltimore, MD 2Morgan State University, Department of Physics, Baltimore, MD

Abstract Some types of nanocomposites are classified as polymer composites, which use inorganic nanoclays as fillers. The material has superior strength, flame and chemical resistance, and barrier properties. In order to make production of these polymer composites more time‐ efficient and affordable, the overall goal of this project is to

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develop a method of monitoring the polymerization process of nanocomposites in situ.

The initial investigation is to characterize nanocomposites’ physical properties. The glass transition temperature (Tg) and extent of reaction of a thermoset (Epon 828 cured with 4,4‐ diaminodiphenylmethane) and three nanocomposites (Epon 828, DDM, and 1, 3, and 5% weight of Nanomer I.28E) were examined using Differential Scanning Calorimetery at two different stochiometric ratios. The data from both ratios indicate that longer isothermal cure times yield higher initial Tgs. The 3.7:1 ratio yielded higher Tgs and a faster cure rate for both thermosets and nanocomposites.

The second investigation examined the degree of exfoliation (uniform dispersion of the nanoclay throughout the polymer composite). Past research has indicated that only minimal percent loadings of nanoclay (not exceeding 5%) are needed and that sonication is an effective method of achieving exfoliation. For these reasons, 1, 3, and 5% were used and sonication was utilized to prepare the nanocomposites. The separation of tactoid layers of cured nanocomposites were compared to that of pure untreated nanoclay using X‐Ray Diffraction. When examining the nanocomposites at the 5:1 ratio, the 3% nanocomposite exfoliated much more than the 1 and 5%. Currently, the experiment is being repeated also using the 3.7:1 ratio to ensure that the results from the 5:1 ratio are reproducible. It can also suggest which ratios produce a better exfoliated product. Future work will entail use of the Dielectric Analyzer to determine the dielectric loss and coefficient for thermosets and nanocomposites. This data could potentially be utilized to develop a method of monitoring the polymerization process in situ. Supported by HBCU‐ UP Program NSF 0505066 and NSF HRD‐0627276.

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“Heating Profiles Of Microwave Irradiated Emulsions”

Sarah A. Addae, Dr. Alvin P. Kennedy*

Morgan State University, Chemistry Department, Baltimore, MD

Abstract The underlying mechanisms involved in the heating of microwave irradiated emulsion systems have not been completely understood. The environment within the micelle and the micelle interface are considered to affect the microwave heating of various liquid emulsions. The objectives of these experiments were to determine the heating profiles of oil in water (O/W) emulsions in real time and determine radiation properties and behavior within these emulsions. Oil in water (O/W) emulsions of various water and hexane compositions were prepared and irradiated in a CEM MDS‐2100 microwave for six minutes and their heating profiles were obtained. The percentage water composition of

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POSTER ABSTRACTS hese emulsions was measured using differential scanning calorimetry. Also, particle distribution was observed under a light microscope and the refractive indexes of the mulsions were measured. Layered systems of water and oil of equal proportions were tudied as controls. The heating profiles of emulsions were observed to be higher than those of corresponding layered systems. Therefore, the power within the emulsions may have ncreased considerably as a result of possible internal reflections within micelles which was hen conducted as heat through out the dispersed phase at the micelle‐dispersed phase nterface‐ a reverse of the heating mechanism in layered systems. Supported by DOE DE‐ FG02 ER63580 and NSF HRD‐0627276.

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35

“Modeling Excitations Energies Of Phenylene‐Vinylene Oligomers For Solar Cell Materials”

LaTonya, Renee, Waller*; Suely, M, Black

Norfolk State University Center for Materials Research Norfolk, VA

Abstract

Organic materials have been targeted for use in electronic and photonic technologies.

Organic‐based devices offer many benefits due to their unique properties which exhibit semiconducting behavior and are flexible and light weight plastics. The geometries and bandgaps of methoxy and sulfone substituted polyphenylene‐vinylene molecules have been studied using B3LYP Density Functional Theory method with a 3‐21G* basis set. The influence of substituent on the bandgaps and the benefits of theoretical experimentation on expected structures before synthesis are discussed.

“Novel Nanomaterials Based On Gold Nanorods And A Thermally‐Responsive Polymer”

Fedena Fanord, Cecil Coutinho, David Walker, and Vinay K. Gupta*

University of South Florida, Department of Chemical Engineering, Tampa, FL

Abstract Gold nanorods (GNR) are anisotropic particles with applications for sensing and diagnostic imaging by virtue of their absorption in the near infrared (NIR) spectral region.

Combining GNRs with polymers has the potential for biomedical applications such as sensing, diagnostic imaging, and localized photothermal treatment. In our research, the focus has been to prepare the novel nanomaterials by chemical coupling of GNR with a 196

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36

thermally responsive polymer, poly(N‐isopropylacrylamide) (PNIPAM). Three different forms of PNIPAM are explored – microspherical gel particles, nanogels of PNIPAM, and l inear polymer chains. The goal is to exploit the optical properties of the GNR in tandem with the stimuli‐responsive polymer for applications ranging from therapeutic treatment as well as diagnostic imaging. In this presentation, we will discuss our progress in surface modifying the GNR with an organic ligand that participates in covalent cross‐linking with the PNIPAM chains. Characterization of the materials with UV‐Vis and infrared spectroscopy, dynamic light scattering, and transmission electron microscopy (TEM) will be presented.

“Synthesis And Magnetic Characterizations Of Manganite‐Based Composite Nanoparticles For Biomedical Applications”

Kai Zhang*, H. Mustafa, L. R. Waller, A. K. Pradhan Center for Materials Research, Norfolk State University, Norfolk, VA Abstract The manganites with a typical composition La0.6Sr0.4MnO3 (LSMO) are fairly metallic with high TC of 380 K and can have large microwave absorption with the possibility of its use in hyperthermia and bio‐marker experiments. Coating the nanoparticles with a suitable material offers many biomedical applications. The composite of magnetic and luminescent nanoparticles, such as Eu:Gd2O3, can have several functionalities. We report on the synthesis and characterizations of silica encapsulated LSMO and Eu:Gd2O3 composite nanoparticles, synthesized by sol‐gel technique. They were thoroughly mixed followed by controlled heat‐treatment. Finally, powders were coated with silica and purified several times. The nanopowders show excellent structural quality. The SEM and TEM images show that the nanoparticles are in the range of 30‐50 nm. The LSMO as‐grown silica‐coated and composite nanoparticles show magnetic transition around 370K with a superparamagnetic behavior at 300K. The ferromagnetic resonance studies of the nanoparticles show desirable line width and magnetism of the composite nanoparticles compared to pure LSMO nanoparticles. Our results suggest that both LSMO and composite nanoparticles can be of potential use in biomagnetic and related applications.

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“Affect Of Superparamagnetic Iron Oxide Agents On NMR And Spin Relaxation In Biological Environments”

Tracee Weaver *, Roselyn Obasi, Dr. Natalia Noginova

Norfolk State University, Center for Materials Research, Norfolk, VA

Abstract

Magnetic nanoparticles, in recent years, have been used to improve technological developments in many disciplines including chemical engineering and biotechnology.

Superparamagnetic iron oxide nanoparticles (SPIO), especially ‐Fe2O3 (maghemite) have been promising for different applications, particularly in the biotechnology as contrast agents for MRI spectroscopy, magnetic carriers for drug delivery, and hyperthermia treatment of cancer. Presently, theory exists for spin dynamics of the host nuclei when in the presence of paramagnetic ions. However, the relatively large objects such as superparamagnetic nanoparticles can have their own specifics.

To get more information on the effect of the nanoparticles to the surrounding, we have studied 1H NMR spectra and spin dynamics of the host system in liquid and solid suspensions of ‐Fe2O3 nanoparticles. Significant broadening of 1H NMR spectra and growing relaxation rates were observed with increased concentration of nanoparticles in the liquid systems, with the relation T1/T2 depending on the particular host. Solid systems demonstrate inhomogeneous broadening of the spectra and practically no dependence of T1 on the nanoparticle concentration. We explain the experimental results taking into account predomination of self‐diffusion as a source of the relaxation in liquid suspensions, and estimate effective parameters of relaxation in the systems studied.

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“Carbon Nanotube Versus Carbon Black‐Filled Epoxy For Electrical Conductivity”

Karen R. Petty*1,2, Matt Weisenberger1, R. Andrews1 1Center for Applied Energy Research, University of Kentucky, Lexington, KY 2Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY

Abstract Various forms of carbon are often used as filler in epoxy or other polymers to produce composites with increased electrical conductivity. Carbon Black (CB) is the most common conductive carbon filler, which when dispersed into insulating polymeric matrices, enables

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conductivity for use in anti‐static electronic packaging materials, conductive coatings, and in some cases, EMI shielding materials. Compared to metallic fillers, carbon has the benefit of being less dense. However, it is generally less conductive. To achieve higher levels of conductivity, high loadings (> 10wt.%) of CB are often necessary, which can render the composite extremely brittle.

Multiwall carbon nanotubes (MWNTs) are an emerging class of carbons, which are more conductive than CB. Furthermore, their high aspect ratio (length/diameter) tends to promote the formation of a conductive network at very low concentration. Here we present results of experiments which measured the DC conductivity of CNT and CB‐filled epoxies at various concentrations. We found that the percolation threshold, or concentration of filler which corresponded to the initial stepwise increase in conductivity, was much lower for MWNT‐filled epoxy than for CB‐filled epoxy. Furthermore, we found that across all concentrations tested, the conductivity of the MWNT‐filled epoxy was at least one order of magnitude larger than CB‐filled epoxy. An important parameter for processing is viscosity. Here, the MWNT‐filled epoxies were clearly more viscous than their CB‐filled counterparts. These results will be discussed in concert with the conductive properties to gauge the trade‐offs between processing and properties for CB and MWNT‐ filled epoxy.

39

“Synthesis And Characterization Of Some Fluorine‐Containing Complexes Of Ruthenium(II)/Platinum(II): Use Of 19F NMR In Studying DNA Interactions”

Lamaryet Moody1, Robert Johnson1, Luke Seymour1, Varma H. Rambaran2, Woodrow Ward1, Eva Clark1, Don vanDerveer3, William Jarrett1, and Alvin A. Holder*1

1Department of Chemistry and Biochemistry, The University of Southern Mississippi, Hattiesburg, MS 2The University of Trinidad and Tobago, OʹMeara Campus, Lots 74‐98, OʹMeara Industrial Park, Arima, Trinidad and Tobago 3Chemistry Department, Clemson University, Clemson

Abstract The American Cancer Society predicts that in 2007, approximately 559,650 people in the U.S.A. will die from cancer. One of the techniques used today to fight cancer is chemotherapy, which involves the use of either organic or inorganic compounds. The discovery of the anti‐cancer activity of the coordination compound cis‐ diaminedichloroplatinum(II) (cisplatin) and its successful clinical use represents important

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advances in inorganic medicinal chemistry. Cisplatin is one of the most widely used and effective oncological agents used against several forms of cancer. However, its clinical usefulness has frequently been limited by severe side effects and the emergence of drug resistance. Thus, thousands of platinum complexes have been synthesized in order to find drugs that have a broader spectrum of activity than that of cisplatin, and reduced side effects.

A reported polyazine‐bridged ruthenium‐platinum bimetallic complex, with a cis geometry analogous to cisplatin, offers several advantages not currently present in platinum‐based drugs. By being a neutral complex, cisplatin has limited water‐solubility.

The addition of a RuII metal center adds an additional +2 charge to the bimetallic complex, allowing for increased water‐solubility. These ruthenium monometallics are also excellent chromophores, which provide a possible spectroscopic handle for examining the binding of these complexes to DNA. The molecular framework of this type of molecule may also be readily changed through the incorporation of different terminal and/or bridging ligands around the ruthenium center, as well as attachment of other moieties. A study of a group of complexes with a varying molecular framework may provide important clues for elucidating the structure‐activity relationships of this new class of supermolecules.

In this study, we report the synthesis of several novel ruthenium(II)/platinum(II) complexes with novel fluorinated ligands. These complexes have a cis geometry, with the general formula cis‐[(N‐N)2Ru(BL)PtCl2] (where BL = a polyazine‐bridged ligand and N‐N is either 2,2’‐bipyridine or 1,10‐phenanthroline). The ruthenium(II)/platinum(II) complexes were characterized by UV‐visible, IR, NMR, and mass spectroscopy, and X‐ray crystallography. Electrochemical studies were carried out on the complexes in CH3CN and aqueous solutions so as to detect the redox potentials of the ruthenium(II) and platinum(II) metal centers and the effect of ligand environment on the redox potentials of ruthenium(II) and platinum(II). Detailed 19F NMR studies involving the interaction of these complexes with DNA plasmids will also be discussed.

40

“Olefin Oligomerization And Polymerization Behavior Of New Titanium‐Based Catalysts Bearing Thiolate Or Phenolate Ligands With Pendant π‐acidic Phosphine Groups”

Leon Dyers Jr., Richard Eaves, Sean Parkin, and Folami T. Ladipo* Department of Chemistry, University of Kentucky, Lexington, KY

Abstract We have recently developed new tridentate ligands bearing POP and PSP frameworks.

Here in, we report the oligomerization and polymerization behavior of their Ti complexes after methylalumoxane activation. Results of studies aimed at elucidating the essential differences between the closely related POP and PSP scaffolds in relation to their abilities to facilitate Ti(IV)/Ti(II) redox for selective olefin oligomerization will be discussed.

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41

“Research Opportunities At The University Of Kentucky”

Leon Dyers Jr. and Folami T. Ladipo*

Department of Chemistry, University of Kentucky, Lexington, KY

Abstract Research opportunities for perspective undergraduates, graduate, and postdoctoral fellows in the Department of Chemistry at the University of Kentucky will be discussed.

Information on research advisors, their groups, and specific concentrations will be available. Also, an overview of our great facilities and beautiful campus will be provided.

This talk will have an emphasis on the recruitment of underrepresented minorities.

42 “Polyelectrolyte Multilayer Coatings With Molecular Micelles In Open Tubular Capillary Electrochromatography”

Candace A. Luces1, Sayo O. Fakayode2, Mark Lowry1, Isiah M. Warner1*

1Department of Chemistry, Louisiana State University, Baton Rouge, LA 2Department of Chemistry, Winston‐Salem State University, Winston‐Salem, NC

Abstract

Capillary electrochromatography (CEC) has shown great potential in the separation of both chiral analytes and proteins. One widely used coating is a polyelectrolyte multilayer (PEM) coating which is formed by alternately exposing the inner wall of a silica capillary to cationic and anionic polymers. The focus of this study involves the development of novel PEM coatings for the separation of both chiral analytes and proteins. The effects of four cationic polymers (poly‐L‐lysine, poly‐L‐ornithine, poly‐L‐lysine‐serine, and poly‐L‐ glutamic acid‐lysine), and three anionic polymers, the molecular micelles (sodium poly(N‐ undecanoyl‐L‐leucyl‐alaninate) (poly‐L‐SULA), sodium poly(N‐undecanoyl‐L‐leucyl‐ valinate) (poly‐L‐SULV), and sodium poly(undecylenic sulfate) (poly‐SUS)), were investigated as potential PEM coatings for protein and chiral separations. The simultaneous effects of cationic polymer concentration, number of bilayers, temperature, voltage and pH of background electrolyte on the separation of four basic proteins (α‐ chymotrypsinogen A, lysozyme, ribonuclease A and cytochrome c), six acidic proteins (α‐ lactalbumin, β‐lactoglobulin A, β‐lactoglobulin B, albumin, myoglobin, and

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deoxyribonuclease I) and three chiral analytes (1,1ʹ‐bi‐2‐naphthyl‐2,2ʹ‐dihydrogen phosphate, 1,1ʹ‐bi‐2‐naphthol, and labetalol) were analyzed using a Box Behnken experimental design. The results show that the optimal coating type and thickness were analyte dependent. The use of molecular micelles in novel PEM coatings have generated versatile stationary phases with potential for the separation of a wide range of analytes.

43

“Investigation Of Enantiomeric Recognition Using Chiral Ionic Liquids Derived From Amino Acid Esters By Spectroscopy”

1 1 David K. Bwambok , Hadi M. Marwani , Vivian E. Fernand1, Sayo O. Fakayode2, Mark Lowry1, Bilal El‐Zahab1, Gary A. Baker3, Ioan Negulescu1, Robert M. Strongin4, and Isiah M. Warner1

1Department of Chemistry, Louisiana State University, Baton Rouge, LA 2Department of Chemistry, Winston‐Salem State University, Winston‐Salem, NC 3Chemical Sciences Division, Nanomaterials Chemistry Group, Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, TN 4Department of Chemistry, Portland State University, Portland, OR

Abstract

Interest in room temperature ionic liquids continues to grow because of their potential as environmentally benign solvents. This is due to their unique properties such as lack of measurable vapor pressure, high thermal stability, and recyclability. Chiral ionic liquids (CILs) have recently received considerable attention in chiral analysis. Pharmaceutical companies are currently required to market single enantiomer drugs, since they display different pharmacological properties. This makes enantiomeric discrimination of chiral drug molecules particularly important. Most of the methods currently used for chiral analyses require the use of different solvents to dissolve the chiral analyte and chiral selector. The use of CILs can alleviate this problem since they can serve as solvents and chiral selectors simultaneously. In this study, the enantiomeric recognition ability of CILs derived from amino acid esters was investigated by use of 19F NMR and fluorescence spectroscopy.

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“Analysis Of CD24 Glycans By MALDI‐TOF‐MS Reveals Prevalence Of Sialosly‐T Antigen”

Edwin Motari*I, Xincheng ZhengII, Yang LiuIII, Mamuka KvaratskheliaIV, Michael FreitasV, Peng G. WangI

I Departments of Chemistry and Biochemistry, The Ohio State University, Columbus, OH IIOncoImmune, Inc. Columbus, OH III Department of Surgery and Internal Medicine, University of Michigan, Ann Harbor, MI IV Center for Retrovirus and Comprehensive Cancer Center, College of Pharmacy, The Ohio State University, Columbus, OH V Department of Molecular Virology, Immunology & Medical Genetics, School of Biomedical Science, College of medicine, The Ohio State University, Columbus, OH

Abstract

CD24 is a glycosyl‐phosphatidyl‐inositol (GPI) linked glycoprotein expressed in a broad range of cell types and is heavily glycosylated. It has been found to be highly expressed in cancers and tumors and is also a costimulatory molecule. Therefore, this study was carried out to define the structures of the carbohydrates associated with this protein. The CD24 glycoproteinʹs oligosaccharides were released by chemical and enzymatic means prior to being analyzed by MALDI‐ToF‐MS.

The results obtained showed that CD24 is N and O‐glycosylated. The major oligosaccharides were found to be Neu5Acα‐2,3/6Galβ‐1,3GalNAc, NeuAc2Gal β‐ 1,3GalNAc1 (O‐glycans), GalNAc2GlcNAc2Man3Fuc1, Gal1GalNAc2GlcNAc2Man3Fuc1, and Gal2GalNAc2GlcNAc2Man3Fuc1 (N‐glycans). The results showed that Neu5Acα‐ 2,3/6Galβ‐1,3GalNAc (sialyl‐tumor antigen, sT), a cancer‐associated carbohydrate, was the most abundant glycan associated with CD24. This result raised the intriguing possibility that CD24 may be a major carrier of the sT abundantly found in cancer cells.

“Investigating The Thermodynamics And Kinetics Of The Alpha‐1,4‐ 45 Galactosyltransferase‐Catalyzed Reaction Of UDP‐Galactose And Lactose”

Kaarina Lokko* and Peng George Wang

The Ohio State University, Department of Chemistry, Columbus, OH

Abstract

Previously, it has been thought that glycosyltransferases catalyzed non‐reversible reactions. However, a recent study indicates that some glycosyltransferases may be able to catalyze a reversible reaction [1]. In order to determine the reversibility of a reaction, its 203

POSTER ABSTRACTS thermodynamic parameters must be known and understood. Alpha‐1,4‐ galactactosyltransferase (LgtC) is an important enzyme in the production of sugar oligomers. It catalyzes the production of galactose‐α‐1,4‐galactose‐β1,4‐glucose.

In this study isothermal titration calorimetry (ITC) was employed to explore the thermodynamic properties of the LgtC catalyzed reaction of lactose and uridine diphosphate‐galactose. At 25 C and pH 7.4, with lactose in excess, ∆H was found to be ‐ 1.9 0.4 kcal/mol (‐7.8 1.8 kJ/mol), which indicates that the reaction is exothermic.

Duplicate measurements using half the previous amount of UDP‐Gal yielded comparable results, where ∆H was found to be ‐2.2 0.1 kcal/mol (‐9.0 0.6 kJ/mol). Statistical analysis confirmed these results to be statistically the same within a 95% confidence interval. The average ∆H of reaction was found to be ‐2.0 0.6 kcal/mol (‐8.4 2.4 kJ/mol).

Analysis employing mass spectrometry and radio assay were used to obtain the free energy of reaction (∆G). Results suggest that this particular reaction is highly irreversible as indicated by a high equilibrium constant.

1. Zhang, C., et al., Exploiting the reversibility of natural product glycosyltransferase‐ catalyzed reactions. Science, 2006. 313(5791): p. 1291‐4.

46

“Direct Analysis Of Amino Acids In Tobacco Products By Liquid Chromatography Tandem Mass Spectrometry”

Kouassi Ayikoe*1, Dawit Z. Bezabeh, Ph.D2, Folahan O. Ayorinde, Ph.D.1, and Md Abdul Mabud, Ph.D.2

1Department of Chemistry, Howard University, Washington DC 2Department of Treasury, Alcohol and Tobacco Tax and Trade Bureau (TTB); 6000 Ammendale Road, Ammendale, MD

Abstract

These are A new method was developed eliminating derivatization of the free amino acids in commercial tobacco products when identified, separated and quantified utilizing a Liquid Chromatography tandem mass spectrometry (UPLC‐MS/MS) technique. This LC‐ MS/MS method was successfully developed utilizing 20 amino acid standards as standards and Valine‐2d8 as internal standard. The R2 for these standards were found to be between 0.980 and 0.998 (table 1). Detection limits for most of the amino acids were found between 0.1 ppm and 1 ppm. Linear dynamic range from 0.05 to100 ug/mL was obtained for most amino acids. Various commercial tobacco products such as cigars, cigarettes, leaves, chewing, snuffs, Burley and flue‐cured were examined and the results compiled.

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POSTER ABSTRACTS “Identification Of Immune Related Proteins From The American Alligator (Alligator Mississippiensis) Using 2D‐Gel Separation And Mass Spectrometry”

Lancia N.F. Darville*1, Mark E. Merchant2 and Kermit K. Murray1

47

1Louisiana State University, Baton Rouge, LA and 2McNesse State University, Lake Charles, LA

Abstract We are using mass spectrometry based proteomics to investigate immune related proteins of the American alligator (Alligator mississippiensis). Alligators have an innate immune system, meaning that they require no specific exposure to an antigen to illicit an immune system response. We are using gel separation and mass spectrometry to study the structure and function of immune related proteins found in alligator serum. Alligators were captured and blood was drawn from internal jugular vein. Adult alligators were injected with lipopolysaccharide (LPS) to activate their immune system. Serum was collected from the whole blood by homogenizing and centrifugation followed by salt removal using 20% trichloroacetic acid. Proteins expressed after exposure to LPS was separated using 2D‐gel electrophoresis. Immobilized pH gradient strips, pH 3‐10 and pH 4‐7 were used. Separation in the second dimension was performed using 8‐16% gradient SDS‐PAGE gels. The down regulated proteins were, isolated and digested for identification. The alligator enzymatic digest was separated using a C18 reversed phase nano‐column and eluted with a linear gradient. Analysis was performed using ESI‐MS/MS on a quadrupole time‐of‐flight mass spectrometer and identified with MASCOT using MSDB and NCBInr database. When the uninfected alligator serum was compared to the LPS exposed serum samples the protein expression changed, indicating that the alligators produce significant innate immunological proteins when exposed to an infection.

“Nucleotide Ion Exchange With Surface‐Confined Ionic Liquid Stationary Phases”

48

Patrice R. Fields* and Apryll M. Stalcup

Department of Chemistry, University of Cincinnati, Cincinnati, OH

Abstract

Modified nucleosides are formed post‐transcriptionally by a number of modification enzymes. These modifications include phosphorylation, glycosylation and methylation.

Modified nucleotides have recently become of interest in cancer diagnosis because patients suffering with various forms of cancer have been found to excrete a higher level of modified nucleosides than healthy adults. Modified nucleotides have previously been separated using capillary electrophoresis and reversed phase high pressure liquid 205

POSTER ABSTRACTS chromatography. Our interest in the area of modified nucleosides involves their separation on a stationary phase capable of both reversed phase and ion exchange mechanisms. Surface‐confined ionic liquid chromatographic stationary phases have been shown to have mechanistic properties dependent on both the cation substituent identity and mobile phase composition.

Ionic liquids are generally composed of a bulky nitrogen containing cation with either an organic or inorganic anion and have melting points that are at or near room temperature.

This work with these stationary phases involves characterizing the retention of polynucleotides as a preliminary study for a later study with modified nucleotides under the same conditions. The stationary phases butylimidazolium bromide, methylimidazolium bromide, benzylimidazolium bromide and a pyridinium bromide have been explored using polynucleotides in 30 mM ammonium acetate with 60% methanol and 60 mM ammonium acetate with 60% methanol. Understanding the variation in nucleotide elution order with stationary phase identity and mobile phase composition can be used to tailor a separation to elute a particular nucleotide first and could be used when interfacing a liquid chromatograph to a detector like a mass spectrometer.

“Spatial And Fluorescence Multiplexing For High‐Throughput Single Molecule 49 Detection”

Paul I. Okagbare*, and Steven A. Soper

Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana

Abstract

The design, performance and application of a new system for high throughput single molecule detection, when configured in a flow‐through format, is reported. The system consists of a microfabricated polymer‐based multi‐channel fluidic network configured with an orthogonal planar waveguide that was placed in the optical path of a laser source (lasing at 680 nm), and a charge couple device (CCD) operated in a frame transfer mode for tracking single molecules as they pass over the planar waveguide. The microfluidic device consisted of 80 shallow channels (dimensions: 10 μm (width) x 1 μm (depth) with a 10 μm pitch) and an air‐embedded waveguide situated orthogonal to the fluidic channels along the width of the PMMA wafer, which defined the excitation volume. The device was double‐sided embossed from a mold insert fabricated by high precision micro milling and defined both the fluidic network and the waveguide geometry. The shallow channel design yielded increased sampling efficiency when the molecules were excited using the evanescent field produced by the planar waveguide. The utility of the detection system was demonstrated through its single molecule sensitivity and its capability for both spatial 206

POSTER ABSTRACTS and fluorescence multiplexing to secure high throughput data processing appropriate for such applications as high throughput screening of drug candidates from combinatorial libraries. As a working demonstration of this system, single DNA molecules were detected, which were labeled with fluorescent tag (AlexaFluor 680) and were identified through their emission wavelength. At its present capacity, the sample throughput of this system is ~2.1 x 106 molecules s‐1. The system was further evaluated through single molecule‐based screening of therapeutic agents for L1‐Endonuclease (L1‐EN), which induces double‐ strand breaks in genomic DNA and has been implicated in aging and various diseases. A double‐stranded DNA substrate was labeled with two fluorescent dyes and fluorescence correlation spectroscopy used to determine the extent of double‐strand breaks induced by the L1‐EN enzyme.

50 “Functional Screening Of Membrane Proteins Expressed In Glioma Cell Lines Using Frontal Affinity Chromatography”

Harrison K. Musyimi, Ruin Moadel, Chester R. Frazier and Irving W. Wainer

National Insitute on Aging, National Institutes of Health, Gerontology Research Center 5600 Nathan Shock Drive, Baltimore, MD

Abstract

Membrane proteins, in particular G‐protein coupled receptors (GPCRs) constitute over 30% of current drug targets. The dynamic nature and complexity of membrane proteins pose a great challenge to the development of rapid online screens for new drug candidates.

We have developed a new approach to this problem through the immobilization of cellular membrane fragments on the surface of liquid chromatographic stationary phases. The resulting chromatographic columns contain functional immobilized membrane proteins, such as GPCRs, and are versatile and reliable for use in new drug discovery and screening of lead drug targets. In here, we describe a liquid chromatography stationary phase based upon membrane fragments obtained from glioma cell lines and the determination that the column contains functioning GPCRs. The presence of the GPCRs in the cell line were initially confirmed using RT‐PCR and Western blot analyses and its function was established using frontal affinity chromatography and appropriate radio‐labeled markers.

The dissociation constants (Kd) and number of binding sites (Bmax) for the identified GPCRs were determined using known selective ligands. The columns were prepared using ~ 107 cells for each cell line and also using a transfected cell line. Multiple GPCRs on the same column were shown to have retained their ability to independently bind receptor‐ selective ligands demonstrating that multipl

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“Investigation Of Ruthenium Complexes And Heptamethine Cyanine Near‐Infrared Fluorophores As Donor/Acceptor Groups For Fluorescence Resonance Energy Transfer (FRET) Analysis”

Isha Pradhan, Maurice Iwunze, Richard Williams*

Morgan State University, Department of Chemistry, Baltimore, MD

Abstract

There has been increasing interest in the use of infrared (IR) and near infrared (NIR) dyes as biological micro‐sensors due to their unique spectral characteristics. Two essential characteristics are the ability to minimize background interference from less useful biological components and the ability to exhibit optimal detection sensitivity and chemical stability. Fluorescence Resonance Energy Transfer (FRET) is an important technique for characterizing biological phenomena that are associated with changes in intermolecular distances. In this study, liposomes were used to identify potential acceptor/donor pairs with luminescent properties in the far red and near infrared region of the visible spectrum for use in FRET analyses. A library of microwave synthesized heptamethine cyanine dyes were incorporated onto liposome surfaces along with Ru(bpy)32+ compounds (bpy = 2,2¢‐ bipyridine). This mixture was excited at the maximum absorbance wavelength of the Ru(bpy)32+ compound and evidence for FRET was searched for at the fluorescence wavelengths of the near‐IR cyanine fluorophores. The results are reported. Supported by DOE DE‐FG02 ER63580 and NSF HRD‐0627276.

“The Effect Of Inositol Hexaphosphate (IP6) On The Proliferation Of The Frog Renal

52

Adenocarcinoma PNKT‐4B Cell Line”

Michael Henderson*2, Nichole L. Powell1 and Roberta M. Troy2

Departments of Chemistry1 and Biology2, Tuskegee University, Tuskegee, AL

Abstract

Inositol hexaphosphate (IP6) is a polyphosphorylated carbohydrate found in high concentrations in cereals and legumes. The anticancer activity of IP6 has been previously demonstrated in vivo and in vitro. The aim of this study was to investigate the dose‐ and time‐dependent effect of IP6 on the proliferation of tumor cells at different invasive states.

The study utilized the frog renal adenocarcinoma PNKT‐4B cell line from Rana pipiens that exhibits temperature‐dependent invasive behavior as a putative cancer model. MTT 208

POSTER ABSTRACTS assays using varying concentrations of IP6 were conducted on PNKT‐4B cells incubated under invasive‐restrictive (18 C) and invasive‐permissive (28 C) conditions. We present the cell viability results obtained from the putative cancer model to results obtained from the human system.

“Proteomics Analysis Of An APP/PS‐1 Mouse Model Of Alzheimers Disease” 53

1 Rukhsana Sultana* , Renã A. Sowell1, D. Allan Butterfield1

1 Department of Chemistry, University of Kentucky, Lexington, KY

Abstract

Extracellular senile plaques (SP) are one of the pathological hallmarks of Alzheimers disease (AD). SP are composed of aggregated forms of amyloid β (Aβ) peptides and result from the cleavage of amyloid precursor protein (APP) by β‐ and γ‐secretases‐ presenilin‐1 (PS‐ 1) is a part of the latter complex. This research employs an APP/PS‐1 human double knock‐in mutant mouse model of AD to investigate mechanisms associated with Aβ(1‐42)‐ mediated neurotoxicity. At nine months of age, fibrillogenic Aβ(1‐42) is present in the brains of APP/PS‐1 animals at substantial levels and a low level of SP. Oxidative stress levels in the brains of APP/PS‐1 animals also increase in an age‐dependent manner that correlates with Aβ levels. Thereby, we hypothesize that oxidative stress caused by Aβ(1‐ 42) leads to changes in the expression levels and oxidation states of key brain proteins.

Subsequently, changes that occur at nine months may provide insight to the mechanisms related to increased SP formation that occurs at later ages. This research employs proteomics and redox proteomics analyses in order to identify brain proteins that change in expression and/or oxidative modification in nine month old APP/PS‐1 animals relative to age‐matched controls. Analyses consist of two‐dimensional gel electrophoresis and Western blotting techniques coupled to image analysis software, mass spectrometry, and database searching methods for protein identification and quantification. Preliminary results from this work will be presented as well as implications for insights into AD pathogenesis. Support is provided by NIH grants to Dr. D. Allan Butterfield.

“Molecular Dynamic Simulations Of The HIV Protease Subtype C” 54

1 T. Dwight McGee , Jesse Edwards1, Adrian E. Roitberg2 1Department of Chemistry, Florida A & M University, Tallahassee, FL 2Department of Chemistry and Quantum Theory Project, University of Florida, Gainesville, FL

Abstract AIDS kills millions of people worldwide. Those victims that acquire AIDS are first infected with the HIV virus before developing AIDS. One of the major targets in anti‐HIV 209

POSTER ABSTRACTS therapeutics is protease inhibition. The HIV protease is a major cog in the reproductive process of the AIDS virus. The protease, cleave gag‐pol proteins creating new viral particles, which later are bud from the host cell to infect other cells. Therefore, protease inhibition prevents the maturation and then spread of the virus. Most of the current research on the AIDS epidemic has been done only on the virus HIV‐1 subtype B. HIV‐1 subtype C is a viral strain, which affects far more people in the world in particular those in developing countries. It has been documented that HIV‐1 subtype C has a higher viral load in the blood, spreads faster than any of the other subtypes, and mutates at a fast rate.

Mutations in the HIV protease brought on by drug treatment make the protease an elusive target. Currently, victims of AIDS are often forced to take drug cocktails to fight the virus at various keypoints in the lifecycle, affecting the victims financially through the cost of the medicines and their quality of life by the shear volume of drugs they are forced to take.

A better understanding of the dynamic motion of the HIV protease would allow researchers to potentially develop new compounds to fight the HIV virus. In this work we present molecular dynamic simulations of over 12ns combined using the crystal structures of two FDA approved inhibitors, nelfinavir, and indinavir complexed with HIV‐1 subtype C protease. These simulations are the first performed on the HIV‐1 subtype C protease (HIV‐PRC) with the drugs extracted from the active site. Analysis of results show three distinct conformations of the loop separations ILE 50 at 7, 10, and 15 angstrom in HIV‐PRC as opposed to only the first two separations in similar MD simulations of HIV‐PRB structures.

“In Vitro Damage Of Naked DNA Upon Exposure To Environmental Factors” 55

Tracie E. Perkins, Martha S. Johnson, Ebony Griffin, and Naomi Campbell*1

1Jackson State University, Jackson, MS

Abstract

Forensic DNA analysis is an important process used within the criminal justice system. However, DNA samples extracted from crime scenes can become severely damaged by environmental agents. Forensic analysis depends on the polymerase chain reaction. DNA damage from environmental agents can inhibit amplification mechanisms.

Most research focus on long-term exposure of DNA to environmental factors. Few experiments focus on damage due to short-term exposure. Hydrogen peroxide and UV light (λ=312 nm) were used for oxidation and UV irradiation, respectively. Native and alkaline gel electrophoresis methods were used to verify double and single strand breaks, respectively. The amount of damage from chemical or UV treated samples was analyzed by comparing the mean and standard deviation for control samples versus treated samples.

Initial results show that UV damage occur as early as 30 seconds upon exposure to UV light, and oxidative damage occurs at 0.3 mM H2O2 upon exposure for 30 minutes.

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“Structural Investigation And Molecular Simulations Of Native And Mutated Spliceosomal U2 snRNA‐Intron Helices: Detection Of Conformational Changes And The Importance Of An RNA Base Triple In The Spliceosomal Core”

Joycelynn D. Nelson1,4, Donghong Min3, Jiang Shao1,2 and Wei Yang*1,2,3

1Department of Chemistry and Biochemistry, The Florida State University, Tallahassee, FL 2Institute of Molecular Biophysics, Department of Chemistry and Biochemistry, The Florida State University, Tallahassee, FL 3School of Computational Science, The Florida State University, Tallahassee, FL 4National High Magnetic Field Laboratory, 1800 E. Paul Dirac Drive, Tallahassee, FL

Abstract

Base flipping is an essential phenomenon for several biological processes which include replication, DNA repair mechanisms, DNA methylation, and transcription. Evidentiary data started motivating us to add splicing to the list. The spliceosome is responsible for the removal or splicing of non‐coding regions (introns), which is necessary to generate a mature messenger RNA that will go on to code for protein. Several experimental data, which include 2‐aminnpurine fluorescence and NMR, revealed that the branch site A branch site helix located in the catalytic core of the spliceosome must assume a flipped conformation to initiate one of two transesterification steps required for the generation of a mature messenger RNA. In the presence of a pseudouridine (ψ) located within the U2‐ snRNA strand, located juxtapose for the branch site A, the nucleophillic 2’hydroyl of the branched A of the intron sequence takes an extrahelical or flipped position prior to the first step of splicing. Another important feature of the branch site helix lies in the presence of a base triple, which is commonly found in other splicing systems. Following the similar strategies as mentioned above, further experimental studies show that the introduction of mutations to any base involved in the base triple may change the conformational preferences of the helix and the branch site A. Molecular dynamics (MD) simulation studies reveal the atomistic details of the conformational changes of the base flipping in the branch site A, and also help us to dissect the structural mechanism of the this process. As comparatively studied, free energy profiles of the unpsuedouridylated construct show that a closed conformation has a lower free‐energy barrier as opposed to flipping, which occurs through a widened major groove. The psuedouridylated construct favors a flipped conformation which also occurs through the major groove. Similar studies were performed on constructs with base triple mutations, which show an intrahelical conformation for the branch site A. This study exemplifies a detailed explanation, on an atomic level, of the mechanistic pathway of the branch site A by which the branch site helix, in the presence of full formed or distorted base triple, undergoes structural divergence to facilitate or hinder proper positioning of the 2’hydroyl of the branch site A 211

POSTER ABSTRACTS prior to the first step of splicing.

“An Isotope Dilution High Resolution Mass Spectrometry 57 Method For Quantitative Measurement Of Isomeric Benzo[A]Pyrene Tetrol Metabolites Derived From Albumin‐Bapde Adducts As Indicators Of Human Exposure To Polycyclic Aromatic Hydrocarbons”

Angela D. Ragin, Kenroy E. Crawford, Christopher Davies¹, James Grainger and Donald G. Patterson Jr

National Center for Environmental Health, Centers for Disease Control and Prevention 4770 Buford Hwy, NE, Atlanta, Georgia ¹Western Kentucky University Department of Chemistry 1906 College Heights Blvd, Bowling Green, KY

Polycyclic aromatic hydrocarbons (PAHs) are formed during incomplete combustion processes and are ubiquitous in the environment. Human are exposed to PAHs through inhalation of compounds in tobacco smoke, vehicle exhaust, ambient air, and consumption of PAHs in foods. Once in the body, PAHs are metabolized to hydroxy metabolites which are excreted out in the urine or they can form covalent adducts with blood proteins such as hemoglobin and albumin. A number of epidemiological studies have shown a strong correlation between PAH related exposure and an increased risk of cancer. These studies have led to intensive efforts to develop analytical methods to identify and measure internal doses of PAHs in biological fluids as a means of assessing exposure. The use of proteins as biomarkers of PAH exposure is a rapidly advancing field. Proteins have stable residence times in blood and are not rapidly cleared from the body. PAH‐protein adducts persist over the lifetime of the protein and provide an extended window for analytical measurements.

We have developed a gas chromatography isotope dilution high resolution mass spectrometry selected ion monitoring (GC‐ID‐HRMS‐SIM) method for measuring isomeric benzo[a]pyrene (B[a]P) tetrol metabolites released after B[a]P‐albumin adduct hydrolysis.

Albumin adducts were isolated from the blood of a cohort of adult male and female smokers and non‐smokers that were randomly selected as exposed and non‐exposed groups. The method was sensitive enough to detect BPTII‐1 and BPTI‐1 in all donors samples analyzed in the low pg range. BPTI‐1 levels were higher than BPTII‐1 levels in both smokers and non‐smokers. The results from this study are the first reported quantitative levels of specific benzo[a]pyrene tetrol isomers using isotope dilution high resolution mass spectrometry measurements of BaPDE‐albumin adducts using 13C6‐ isotopically labeled BaP tetrol isomer standards.

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“Elucidation Of The Roles For Arginine And Tyrosine In The DNA Binding Properties Of The NZF‐1 Zinc Binding Domains”

Ieashia Starr Lewter*, Holly J. Cymet, PhD

Department of Chemistry, Morgan State University, Baltimore, MD

Abstract Neural zinc finger factor 1 (NZF‐1), a protein found in nerve tissue, is a transcription factor that contains six zinc‐binding domains. These zinc‐binding domains use Zn2+ to fold and

are responsible for the protein’s DNA binding activity. A minimum of two domains are required for specific DNA binding. Little is known as to which specific amino acids within the domains of NZF‐1 directly interact with the DNA bases, and this research will attempt to assess this interaction more closely. Analysis of the three‐dimensional structure of a single NZF‐1 domain suggests that a conserved arginine and a semiconserved tyrosine may each play a role in DNA recognition. Our study used a fragment of NZF‐1 containing two zinc binding domains, referred to as NZF‐1b. Mutations in the first domain, consisting of R39A or Y35F, were generated. The mutant proteins were expressed in BL21 DE3 bacteria and then purified from the bacterial supernatants using a SP sepharose cation exchange column. SDS‐PAGE analysis confirmed proper expression and a ~95% purification of the proteins. NZF1b:R39A and NZF1b:Y35F were further purified by HPLC on a C18 reversed phase column to remove bound metal. The metal‐binding affinities of mutant peptides for cobalt(II) and zinc(II) were determined by UV‐vis spectroscopy and were comparable to that of the wildtype peptide. This indicates that the mutations did not disrupt peptide folding. DNA binding studies using fluorescence anisotropy are underway to determine the importance of Arg‐39 and Tyr‐35 on the DNA binding abilities of the NZF‐1 zinc binding domains.

“Signal Amplification By Redox Cycling At An Integrated Microelectrode Array In A 59 Microchannel Device”

Leethaniel Brumfield, III *, Penny Lewis, Emily Anderson, Dr. Ingrid Fritsch

Department of Chemistry & Biochemistry, University of Arkansas, Fayetteville, Arkansas

Abstract

Background The interest in the development of automated devices that can perform multiple steps for the analysis of samples using small volumes has generated research involved in developing new ways of incorporating electrochemical detectors with these lab‐on‐a‐chip (LOC) devices. Purpose/Problem A new device that integrates a poly(dimethylsiloxane) (PDMS) microchannel with a microelectrode array for electrochemical detection of a sandwich type immunosorbant assay (ELISA) was 213

POSTER ABSTRACTS fabricated and characterized. The PDMS channel was adhered to a glass slide containing the electrode array and the channel was closed by clamping the PDMS covered glass slide with a piece of plain or gold coated silicon wafer. Materials & Method The electrode array used contained 20 individually addressable electrodes. The working electrodes were 50 mm wide and 500 mm long, separated by 25 mm gaps. Its length was defined by the 500 mm wide and 29 mm deep channel. This device was used to investigate the signal amplification effects of generation/collection (redox cycling) experiments and the advantages of this type of electrochemical detection for use in detecting para‐aminophenol (PAPR), the electroactive species generated in the mouse IgG sandwich type ELISA model system. Results Instrumentally‐induced (or active) redox cycling resulted in amplification factors as high as 1.65 V for the closed channel, internal 3‐electrode setup. The observable detection limit of PAPR was determined to be 4 mM. Discussion Preliminary results for the detection of PAPR, generated by incubating para‐aminophenylphosphate (PAPP) with the immunoassay, indicated at this device was an effective detector for the mouse IgG model system. Conclusion Future work will involve determining the optimal electrode dimensions, interelectrode spacing, and electrode configuration for achieving the highest signal amplification. Once the device is perfected, it can be used to optimize the mouse IgG model system. Even lower detection limits are expected because smaller interelectrode spacing and smaller electrodes enhance the effects of redox cycling. The mouse IgG model system can later be applied to developing assays for the detection of other biological species of medical interest, such as paralytic shellfish toxins.

* To whom correspondence should be addressed: Telephone: (405) 922‐2219; Mail: 601 S. Washington Street #293, Stillwater, Oklahoma 74074; E‐Mail: leleethaniel@yhaoo.com

“Unbiased Ligand Discovery For Histone Deacetylases Using Small Molecule 60 Microarrays”

Nicole M. Martinez*, Jason Fuller1, Angela N. Koehler1

1Broad Institute of MIT and Harvard, Chemical Biology Program, Cambridge, MA 2University of Puerto Rico, Department of Biotechnology, Mayaguez, PR

Abstract Histone Deacetylases (HDACs) play a role in cancer biology through a number of diverse pathways: gene expression, oncoprotein stability, cell migration, protein catabolism and cell cycle control. Inhibitors targeting HDACs have therefore been developed as anti‐ cancer agents. Few HDAC inhibitors are isoform selective. For this reason allosteric inhibitors are highly desirable. Small‐molecule microarrays were used to detect preliminary HDAC binders. More than half a million biophysical assays were performed from different small molecule libraries. A detailed hit comparison of six different HDACs on a diversity oriented synthesis library was performed. Common hits for HDACs ranged 214

POSTER ABSTRACTS in functional groups that could mediate protein‐ligand interaction. All HDAC6 specific binders came from HDAC biased libraries selecting for a five carbon aliphatic linker.

Future binding kinetics, in vitro activity and phenotypic assays will asses inhibitory capabilities.

61 “Generation Of Stable Fluorescent Expression In Target Cells Used To Characterize Ex Vivo Cytolytic T Cell Function”

Oluwadamilola T. Oladeru*1, Meghan Jendrysik2, Uimook Choi3 and Sharon Jackson4.

Molecular Trafficking Unit/ Lab of Host Defenses, National Institutes of Health, Institute of Allergy & Infectious Diseases, Bethesda

Abstract

The EL4 derived cell line, E.G7‐OVA, carries a complete copy of chicken ovalbumin (OVA) mRNA and the neomycin (G418) resistance gene. Preliminary investigations were done using CFSE (carboxyl‐flourescein diacetate, succinimidyl ester) labeled EL‐4 and E.G7 target cells. However, there has been inconsistent CFSE labeling of the target lines and variable results in in vitro killing assays. In addition CFSE is diminished in rapidly proliferating cells therefore limiting its utility in certain in vivo assays. The generation of modified target cells, E.G7‐OVA and EL‐4, that stably expresses fluorescent proteins such RFP and GFP will be valuable tools for investigating ex vivo antigen specific T‐cell function as well as APC function in NADPH oxidase p47phox deficient‐Ova TcR transgenic mice.

EL4 and E.G7 cell lines were cultured in RPMI medium before viral infection and later transduced with Eco/MFGS‐GFP MGMT virus that expresses GFP, green fluorescent protein. E.G7 cells were transduced with HIV Lenti‐CMV RFP virus made from transfected plasmids with 293FT cells. EL‐4 cell lines expressing GFP were selected through three days of treatment with BG/BCNU and separated using a Lymphocyte Separation Medium.

However, positive E.G7 cells expressing RFP were selected using FACS.

Using a flow cytometer, results showed that about 30% of the EL‐4 cell line transduced with Ecotropic MFGS‐GFP MGMT virus fully expressed GFP while none of the naïve cells expressed GFP as expected. After selection, it rose to about 93% GFP expression. After three days of transducing E.G7 with the viral construct, HIV Lenti CMV RFP using 293FT , about 10% of the cell line fully expressed RFP. After selecting for positive E.G7 cells expressing RFP using the FACS, the percentage rose to about 82%. The new target cell lines, EL‐4 expressing GFP and E.G7‐OVA expressing RFP, will be used in semi‐ quantitative assays of cytotoxic T lymphocyte induced killing of specifically labeled target cells. Also, ex vivo characterization of CTL in heterogeneous primary cell and the evaluation of the MHC restricted target cell lysis will be investigated. Moreover, the 215

POSTER ABSTRACTS stability of the fluorescent signal will allow for the ex vivo analysis in slow CTL effector mechanisms in a time frame of days instead of hours. Lastly, these target cells will be used to investigate APC functions in p47phox deficient‐OVA TCR transgenic mice.

“Measurements Of Tissue Transglutaminase (tTg) Protein Concentration In Human 62 Breast Cancer Cells”

Reaya Richardson, Irine Chepkoech, Dr. Bassam Fraij

Department of Biology, Chemistry and Environmental Health Science Benedict College, Columbia, SC

Abstract

Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. If the spread is not controlled, it can result in death. African American women are more likely to die from breast cancer than other ethnic groups, which may be part due to late diagnosis, early onset, or aggressiveness of tumor. Tissue transglutaminase is an enzyme of the transglutaminase family. It cross‐links proteins between and ε‐amino group of a lysine residue and a γ‐carboxamide group of glutamine residue, creating an inter‐ or intramolecular bond that is highly resistant to proteolysis (protein degradation).1 It is particularly notable for being the auto‐antigen in coeliac disease, but is also know to play a role in apoptosis, cellular differentiation, and matrix stabilization. Researchers have shown that cancer cells selected for resistance against chemotherapeutic drugs or made inaccessible from metastatic tumor sites have high levels of proteins that are dependent of calcium cross‐linking enzyme, tissue transglutaminase (TG2) but there has been no direct link between TG2 and resistance established.2 Apoptosis is the controlled mechanism through which certain cells die to prevent themselves from becoming cancerous. This study is a primary investigation into the relationship between tTG expression levels and breast cancer survival. By using various techniques, CBB and BCA, to measure the concentration in human breast cancer cells, MCF‐7 and T47D. Measuring the total concentration of protein was used to detect by using Western Blots. Tissue transglutaminase activity will be measured by a radioactive method to be correlated with tTG and protein concentration.

1 Liu, Shenping et. al. Med.Chem. 2002(99):2743‐2747.

2 Herman, J. F. et al. Chem. Rev. 2006, 3049‐3058

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POSTER ABSTRACTS 63

“A Computational Process To Locate IS Elements And Study Horizontal Gene Transfer In Bacterial Genomes”

Walter J. Lewis*2, Wenyi Bi2, Sean R. McCorkle 1, Daniel Van DerLie1

1Brookhaven National Laboratory, Upton, NY 2Cheyney University of Pennsylvania, Cheyney, PA

Abstract

Currently there is a tremendous focus on studying how whole units of DNA are shared between species. These movable tracks of DNA, called transposons, are demarcated by shorter insertion sequence (IS) elements, which themselves are generally around 700 to 2500 bp in length, and code for proteins implicated in transposition activity, such as transposase and intergrase. IS elements are bracketed by pairs of inverted repeats of variant length (approx. 10 ‐30 bp), and are further embedded in a pair of short direct repeats of approximately 3 – 7 bp. While there is a great deal of software to automatically annotate genes and regulatory regions, there are currently no programs to identify IS elements de novo. Hundreds of completed bacterial genomes are currently available and more are constantly being added to that list, which makes it increasingly important for the computational detection of IS elements. To this end, we have developed a C++ program to locate IS elements in bacterial genomes. The process was broken down into steps in order to make it more dynamic so that one could easily examine the data in each stage of the process to detect errors, or perhaps discover something unexpected. First, all repeats (within length constraints) are reported, and then these are searched for pairs of inverted repeats which have the proper orientation and distance. Positions, paired inverted repeat sequences, and interior coding sequences are reported for these IS element candidates.

Lastly the interior coding sequences are examined for homology with known transposition genes. Preliminary tests on the genome of Enterobacter strain 638, recently sequenced as part of the DOE biofuels initiative, revealed 9 putative IS candidates, 6 of which were confirmed by Blastx searches of Genbank, which yielded strong homology matches to transposase and intergrase in other organisms. Further testing on an IS‐rich genome, now Cupriavidus metallidurans (CH34), will allow us to optimize program parameters to improve performance. Because this process reports direct and inverted sequence pairs, which travel along with the IS element as it moves, it can be used to trace horizontal gene transfer history within or between genomes for evolutionary studies.

217

POSTER ABSTRACTS “An Examination Of Binding Energies In Biologically Relevant Systems Using Chemical Microscopy Of Protein Surfaces”

Chanel C. King, Dr. Carl Bonner*, and Dr. Katina Patrick

Center for Materials Research and Department of Chemistry, Norfolk State University, Norfolk, VA

Abstract

Chemical reactions have associated binding energies. These binding energies tell how much energy is required to form a product. This research delves into the energetics of relevant biological systems, more specifically enzyme and substrate interactions.

The objectives of this research include (but are not limited to) mapping a particular surface using Chemical Force Microscopy, mapping the surface of an enzyme and substrate docking site using Bound Ligand Force Microscopy, studying the topology of surface using AFM and ultimately comparing the experimental results with the appropriate computer model.

Measuring attractive and repulsive forces by using various microscopy techniques maps the surface. Force curves are made to monitor those forces. A model is made using alkanethiol‐gold chemistry. Alkanethiol‐gold surface chemistry is a widely used technique that allows for different functional groups to be attached to a gold surface. Gold is important because it is biologically safe on the cellular level. Therefore it is a prime candidate for experimentation. Desired functional groups were transferred to the surface in an ordered manner. It was hypothesized that every group interacts with the surface with a certain amount of force. Once that value is known, you can experimentally find if that group present in your biological system. Additionally, the topology of the surface was determined. After, an enzymatic substrate will be allowed to react with an enzyme surface. The forces will be noted and compared with the model. The finding will then be compared with an appropriate computer model.

“Studies Toward The Synthesis Studies Of Spiroisoxazolines” 65

Erick D. Ellis*, Jianping Xu, and Ashton T. Hamme 64

Jackson State University, Department of Chemistry, Jackson, MS Abstract A series of natural products isolated from the sponge of Verongida have been intensively studied due to the presence of alkaloids with one, or more bromotyrosine residues. Many of these alkaloid metabolites show interesting bioactivity and cytotoxic properties in tumor cell lines. 11‐Deoxyfistularin‐3 is cytotoxic against human breast carcinoma cell line MCF‐ 218

POSTER ABSTRACTS 7. Many of these bromotyrosine natural products possess the spiroisoxazoline moiety.

The purpose of this project was to find a synthetic methodology towards the synthesis of the spiroisoxazoline ring core. The synthesis of the 4,5‐dihydroisoxazole precursor to an analogue of 11‐deoxyfistularin‐3 was accomplished by using 1,3‐dipolar cycloaddition with a functionalized alkene. The synthesis of 2‐acetyl‐4‐methylene‐pentanedioic acid diethyl ester was accomplished through the addition of sodium hydride to ethylacetoacetate which then reacted with 2‐bromomethyl‐acrylic acid ethyl ester. The cycloaddition of 2‐acetyl‐4‐methylene‐pentanedioic acid diethyl ester with phenyl hydroximoyl chloride using triethylamine in dichloromethane afforded only the 5,5 disubstituted 4,5‐dihydroisoxazole regioisomer. The synthesis of the spiroisoxazoline, 8‐ Methoxy‐3‐phenyl‐1‐oxa‐2‐aza‐spiro[4.5]deca‐2,7‐dien‐6‐one, was accomplished through the cyclization and alkylation of the decarboxylated isoxazoline precursor, 5‐(3‐Oxo‐butyl)‐ 3‐phenyl‐4,5‐dihydro‐isoxazole‐5‐carboxylic acid ethyl ester. In order to improve and accelerate our process of forming the spiroisoxazoline, acetone and 2,4‐pentadione were used to form 2‐methylene‐5‐oxo‐hexanoic acid ethyl ester. Next, the 1,3‐dipolar cycloadditon of 2‐methylene‐5‐oxo‐hexanoic acid ethyl ester with the analogous nitrile oxide formed 5‐(3‐Oxo‐butyl)‐3‐phenyl‐4,5‐dihydro‐isoxazole‐5‐carboxylic acid ethyl ester.

Finally, 8‐Methoxy‐3‐phenyl‐1‐oxa‐2‐aza‐spiro[4.5]deca‐2,7‐dien‐6‐one was synthesized by cyclization and alkylation of the carboxylic acid ethyl ester.

“Synthesis And Characterization Of Water Soluble Monofuntional Pt(Ii) Complexes 66 Useful For Biological Labeling”

Margaret W. Ndinguri, Frank R. Fronczek, Robert P.Hammer and Luigi G. Marzilli*

Department of Chemistry, Louisiana State University, Baton Rouge, LA

Abstract

Cisplatin, a widely used anticancer drug, is known to interact primarily with DNA and many proteins that are vital to DNA replication and cell division. The studied binding mechanism has been linked to the formation of monoaquated and diaquated species however, the active form has not been determined. In this study we present novel tridentate fluorescent ([Pt(atfcdien)Br]Br) and non‐florescent platinated ligand ([Pt(acdien)Br]Br) that forms mononfuntional complexes which are capable of binding to the (N7) of the purine of guanosine 5′‐monophosphate (5′‐GMP). 1H NMR measurements, allowed us to monitor the interaction of the platinum complexes with (5′‐GMP) with a decrease of unreacted species and formation of new platinated species visible on NMR timescale. On the other hand, fluorescence spectroscopy would enabled monitoring of the kinetics and interaction of DNA with monofuctional platinum complex in the presence of other peptides in invitro studies while elemental analysis confirmed the purity of the ligands.We accomplished the synthesis and solution characterization of 219

POSTER ABSTRACTS [Pt(atfcdien)Br][Pt(Me2SO)Br3], Pt(atfcdien)Br]Br and [Pt(acdien)Br]Br complexes by employing various synthetic steps. The presence of 7‐amino‐4‐(trifluoromethyl)coumarin group on the carrier ligand introduces the fluorescent property in the ligand, which allowed us to monitor and study the ligand interaction with DNA by fluorescence. Also the solubility of both Pt complexes allowed aqueous solution studies under physiological conditions, both with DNA and other biological molecules. These new complexes have desirable features for assessing the potential of tridentate platinum complexes for investigating selective monocoordination of metal complexes to DNA and to peptides.

67 “Design & Synthesis Of Non‐Cyclic Imido‐Substituted 2‐Chloro 1,4‐Naphthoquinone Derivatives As Mek1 Inhibitors And Potential Anticancer Agents”

Yakini S. Brandy, and Oladapo Bakare*

Department of Chemistry, Howard University, Washington, DC

Abstract Mitogen‐activated protein kinase kinase 1/2 (MEK1/2) are dual specificity protein kinases in the Ras‐MapK (mitogen‐activated protein kinase) cascade which is activated by a wide range of extracellular signals. The Ras‐MapK pathway is known to control cellular proliferation, differentiation and survival, and has been implicated in many human diseases including cancer. Inappropriate activation of the Ras‐Mapk pathway is reported in about 30% of all human cancers. Consequently, the kinases in the Ras‐Mapk signaling pathway have become attractive targets for the development of novel therapeutic intervention in human carcinomas. We have reported 2‐chloro‐3‐(N‐succinimidyl)‐1,4‐ naphthoquinone as a selective MEK1 inhibitor. An open chain analog, 2‐chloro‐3‐ dibutyrylamino‐1,4‐naphthoquinone, was found to possess multi‐kinase inhibitory activities and exhibited selective cytotoxicity against a panel of renal and prostate cancer cell lines. Designing more potent selective anticancer agents in our prostate cancer program, we have designed the synthesis of several non‐cyclic imido‐substituted chloro‐ 1,4‐naphthoquinone analogs. The reaction of 2‐amino‐3‐chloro‐1,4‐naphthoquinone with sodium hydride followed by nucleophilic acyl substitution reaction of the resulting nucleophile on appropriate acid chloride furnished a mixture of the amido‐ and imido‐ substituted derivatives. The target imido‐substituted analogs were isolated by column chromatography on silica gel and/or by recrystallization from appropriate solvents. These compounds were characterized by infrared (IR) spectroscopy, nuclear magnetic resonance spectroscopy (1H & 13C‐NMR) and electrospray‐ionization mass spectrometry.

220

POSTER ABSTRACTS “Efforts Toward The Synthesis Of (+)‐Kalkitoxin And Some Analogs”

Adeleke A. Oni*, Everett W. Merling, and Richard J. Mullins

Xavier University, Department of Chemistry Cincinnati, OH

68

Abstract

The lipopeptide (+)‐kalkitoxin (1), a metabolite produced by a member of the Lyngbya majuscula family of cyanobacteria, has been shown to exhibit several antiproliferative biological properties. The most noteworthy of these properties is its cytotoxicity to an array of aquatic creatures as well as toxicity to rat neurons and human colon cancer cell lines. On the basis of this interesting bioactivity profile, we have embarked on a quest to better understand the manner by which it prevents the growth of tumor cells. Our efforts toward the total synthesis of kalkitoxin and some analogs will be presented.

“Chemical And Pharmacological Studies Of A Plant Belonging To The Guttifereae 69 Family: Mammea Africana”

Ghislain Tchomobe*

Department of Chemistry, University of Buea, P.O. Box 63, Buea, Cameroon

Abstract Natural substances from plants with medicinal properties represent an important source of molecules with therapeutic values and as such, their large variety can be exploited. But they also serve as a model or building blocks for the synthesis of a large number of molecules some of which have pharmacological values. The aim of this work, which involves both the ethnopharmacological usage and the recent results obtained on some of the chosen plant, is based on natural products research orientated towards antimicrobial and vasorelaxant activities and/or to obtain suitable compounds against cancer and hypertension. For instance, working on Mammea africana, plant used in cameroonian ethnomedicine for the treatment of the fever, malaria and high blood pressure, we have isolated from the methanol/CH2Cl2 extract of the stem bark, three 4‐ alkyl substituted coumarins (Mammea B/BB, Mammea B/BA, Mammea C/OB) and three 4‐phenyl substituted coumarins (Mammea A/AA, Mammea A/BA, MAB3). While all these compounds exhibited noteworthy cytotoxicityvity against human 9‐KB cell line, only 4‐ alkyl substituted coumarins were found to exhibit significant antibacterial activity against Gram + bacterium, Staphylococcus aureus Some compounds amongst them were isolated also from the CH2Cl2 fraction mammea B/BB, mammea A/AA and mammea B/BA might involved in the vasorelaxant effect which inhibited noradrenaline (NA) or KCl‐induced contraction in isolated guinea pig and rat aorta.

221

POSTER ABSTRACTS “Physical Characterization Of Chitosan Using Dilute Solution Viscometry”

70

Abdul‐Rahman Raji, Alvin P. Kennedy*

Morgan State University, Department of Chemistry, Baltimore, MD

Abstract

A fluorescent derivative of chitosan has been synthesized for development of biosensors.

The goal of this research is to characterize the physical properties of the chitosan sample.

The molecular weight was first determined. Molecular weight is a fundamental and quantitative physical property of matter, and it has a significant effect on both the physical and chemical properties of a substance.

A cannon‐fenske viscometer was used to measure the flow time of the sovent (0.25 M CH3OOH/0.25 M CH3OONa) and five chitosan solutions. The solutions were prepared by diluting a stock solution of chitosan to obtain different concentrations. Relative viscosity, specific viscosity, reduced viscosity, and inherent viscosity were calculated from the flow time and the concentration data. The molecular weight was determined from Mark‐ Houwink equation, [η] = kMa, where k and a are constants for the chitosan‐solvent.

The intrinsic viscosity was determined to be 2.75 dL/g, and the molecular weight was calculated from Mark‐Houwink‐Sakurada equation, [η] = KMa, where “k” and “a” are constants for the chitosan‐solvent used, and [η] and M are intrinsic viscosity and molecular weight, respectively. The Mark‐Houwink constants used for the determination of the viscosity average molecular weight were K = 1.40 × 10‐4 dL and a = 0.83. The molecular weight was thus 1.48 × 105. Supported by DOE DE‐FG02 ER63580 and NSF HRD‐0627276.

“Shear And Elongational Rheology Of Membrane Dopes” 71

Kayode O. Olanrewaju, Victor Breedveld*

Georgia Institute of Technology, School of Chemical & Biomolecular Engineering, Atlanta, GA

Abstract

Membrane‐based gas separations are environmentally benign and energy efficient and are becoming a more attractive separation choice. Mixed matrix hollow fiber membranes were recently conceived for improved membrane performance. Each fiber in this type of membrane is composed of molecular sieves (zeolite particles) dispersed in a polymer matrix spun into a hollow fiber configuration. We will present experimental data on the 222

POSTER ABSTRACTS shear and extensional rheology of Ultem/NMP solutions with and without suspended surface‐modified porous/nonporous zeolite (ZSM‐5) particles.

We found that the zeolite particles suspensions have relative viscosities that significantly exceeded the Krieger‐Dougherty predictions for hard sphere suspensions at particle loadings up to 30 weight %. We will show that the major origin of this discrepancy is the selective absorption of the NMP solvent into the zeolite nanopores. Solvent absorption raises the particle and polymer concentrations, and thus increases both the viscosity of the Ultem/NMP continuous phase and the particle contribution to suspension viscosity. Other factors, such as particles non‐sphericity and interactions of particles with Ultem polymer, increase the suspension viscosity to a lesser extent. We propose a predictive model for the viscosity of porous zeolite suspensions by introducing an absorption parameter, α, into the Krieger‐Dougherty model. We also propose independent approaches to determine α.

The different approaches will be compared and evaluated.

Using a capillary‐breakup extensional rheometer (CaBER) we also measured the transient extensional viscosities of Ultem/NMP solutions and zeolite/Ultem/NMP suspensions. We determined mean relaxation times, transient and quasi‐steady apparent extensional viscosities for Ultem/NMP solutions. The relaxation times of Ultem/NMP solutions increases significantly when doped with porous zeolite.

“The Bioeffects Of Metallized Nanotubes” 72

Edidiong Obot *1, Prathyush Ramesh1, Renard Thomas2, Prabakaran Ravichandran3, Govindarajan Ramesh3, Bobby Wilson4

1Space, Engineering, and Science Internship Program (SESIP), Texas Southern University, Houston, Texas 2NASA University Research Center, Texas Southern University, Houston, Texas 3Molecular Neurotoxicology Laboratory, Texas Southern University, Houston, Texas 4SESIP Program Director, Texas Southern University, Houston, Texas

Abstract

The application of Carbon Nanotubes (CNT’s) in the field of modern medicine such as drug delivery, virus detection, molecular methods for disease diagnosis have recently started to emerge and hence they are expected for the large scale industrial production.

However the use of CNT`s in various fields, especially in medical applications raises serious concerns about health and safety issues. Currently there are several areas that are looking towards nanotechnology as a new form of enhancement, however because this kind of technology is so new we lack the knowledge of its various effects that could affect our society. In our study we tested the toxicity level of Single Wall, Multi‐Wall, and Metallized Carbon Nanotubes in lung epithelial cells. The purpose of our research is to 223

POSTER ABSTRACTS determine the toxicity level of Metallized Carbon Nanotubes in lung epithelial cells. The purpose of our study relates to the possible affects in industrial workers due to inhalation testing. CNT’s could become airborne during manufacturing process and handling and would result in inhalation and skin exposure of workers to particles causing unknown toxic response.If we test the Metallized Carbon Nanotubes we can see what kind of effect it would have particularly in our pulmonary system. We believe that if there is an attraction between the cells and the Metallic Carbon Nanotubes then it will cause a toxic response in the cell. The research will consist of culturing a cell line of lung epithelial cells, exposing the lung epithelial cells to a Metallic Carbon Nanotube, Muti‐Wall Carbon Nanotubes, and Single Wall Nanotube and compare the outcome, checking the toxicity using MTT and live dead cell assays in order to its test the vulnerability or resistance, comparing its Reactive Oxidative Stress (ROS), and using Transmission Electron Microscope (TEM) and Scanning Electron Microscope (SEM) to determine if the nanoparticles entered the cell. Based on our results we were able to determine that Metallized Carbon Nanotubes are more toxic than Single‐Wall and Multi‐Wall Carbon Nanotubes. Results show there is a direct relationship between the number of cells dying and its Reactive Oxidative Stress.

“The Materials Research Facilities Network (MRFN), a National Research and 73 Education Resource”

1 1 Anika A. Odukale* , Craig J. Hawker , Timothy P. Lodge2, Thomas P. Russell3, Marek W. Urban4

1Materials Research Laboratory, University of California, Santa Barbara, CA 2MRSEC, University of Minnesota, Minneapolis, MN 3MRSEC on Polymers, University of Massachusetts, Amherst, MA 4Center for Response‐Driven Polymeric Films, the University of Southern Mississippi, Hattiesburg, MS

Abstract The Materials Research Facilities Network (MRFN) is a collaborative effort established between the MRSEC facilities at the University of California, Santa Barbara (UCSB), the University of Minnesota, the University of Massachusetts, Amherst, and the University of Southern Mississippi, which is focused on increasing the visibility and usage of analytical and computational instrumental centers within the materials, engineering, and overall greater scientific community.

The goal of the MRFN is to function as a national network that supports and promotes the growth of the materials science field in the US, as well as increase its ability to compete internationally. The centers address the growing need for advanced characterization and computational tools from both academic (large and small colleges) and industrial 224

POSTER ABSTRACTS scientists in materials research. By taking advantage of the tools and talents distributed throughout the program, the individual MRSEC facilities can integrate the capabilities of materials research centers into a cooperating network.

In an effort to become a role model for MRSEC networks in general, the success of the MRFN provides enhanced coordination between MRSEC’s, as well as greater exposure of the benefits of the MRSEC program, to the larger materials society. Additionally, the MRSEC Facilities Network will be further promoted to the broad materials community with a focus on both primarily undergraduate and minority serving institutions, while also building inter‐MRSEC collaborations.

By providing assistance to potential users of the facilities through training, access to instrumentation centers, and supplemental funding, the MRFN will promote mutual efforts to establish long term relationships within the scientific community. In its efforts, the MRFN can provide the resources required for users to utilize critical analytical problem solving techniques, which can significantly contribute to the research and industrial sectors of the nation through improved access to high‐end instrumentation and knowledge at a modest expense.

“Enhancing High School Chemistry Classes With Student Support” 74

Edward D. Walton*1, Michael F. Z. Page1, Joelle Opotowsky1, Laurie Riggs1, and Brenda L. Olsen

1California State Polytechnic University, Pomona, CA 2Diamond Ranch High School, Pomona, CA

Abstract High school chemistry teachers are faced with tremendous challenges in teaching our science to students. According to the National Academies Americaʹs Lab Report: Investigations in High School Science (2005), “Laboratory experiences have the potential to help students attain several important learning goals, including mastery of science subject matter, increased interest in science, and development of scientific reasoning skills. That potential is not being realized today… Improving high school science teachersʹ capacity to lead laboratory experiences effectively is critical to advancing the educational goals of these experiences.”

We have developed a teacher/student program that trains high school students to become effective teaching assistants to their chemistry teachers. The students received a certified tutor‐training course, they were trained in peer instruction, inquiry based science‐ teaching, and short classroom presentations. They got experience working with teachers in conducting hands‐on inquiry based activities and presentation of chemical demonstrations.

225

POSTER ABSTRACTS

Ten teachers and 25 students participated a summer “Chemistry Teaching” program.

During the academic year after that participation 18 of the students are working with their teachers in the classroom. Some stay after school each week to help prepare labs. Some have been assigned as “lab aids” or student assistants. The students are receiving “service credits”, or credits for ʺAdvanced Science Independent Study.ʺ

We share here how the program was designed to produce effective outcomes.

75 “Exciting Middle And High School Students In Chemistry Via Advances In Materials Science”

Sherine O. Obare*, Tova A. Samuels and Ruel G. Freemantle

*University of North Carolina at Charlotte, Department of Chemistry and the Nanoscale Science PhD Program Charlotte, NC

Abstract

The twenty‐first century requires the training of scientists and engineers in interdisciplinary fields to enable them to address evolving challenges in science and technology. The ability to train future scientists at an early age provides significant promise toward increasing the number of individuals that can tackle various scientific and technological problems. An excellent way to educate students and get them excited about chemistry and materials science is by choosing exciting experiments that are life‐ related. We have developed a number of significant projects for middle school and high school students to help them understand how chemistry and materials science can lead to significant advances in alternative energy. The projects provide an opportunity for young students to have hands‐on learning experiences with instruments used in research laboratories while increasing their skills and understanding of modern scientific technology. These projects not only stimulate studentsʹ interest in chemistry, but further demonstrate the relevance of chemistry to everyday life.

76 “Upgrading The Design Of A Traditional Physical Chemistry Laboratory Experiment: Determining The Heat Of Vaporization (∆Hvap) Of A Pure Liquid”

Shawn M. Abernathy* and Anwar D. Jackson Howard University, Department of Chemistry, Washington, DC Abstract The physical chemistry laboratory course is traditional the last, the most sophisticated and professional laboratory in the undergraduate chemistry curriculum. Physical 226

POSTER ABSTRACTS chemistry is a branch of chemistry that studies the physical principles underlying the properties of chemical substances via the use of mathematics and physics. It contains theories that have withstood experimental scrutiny and is continuously growing at an enormous rate due to new experiments. Among many students, physical chemistry has garnered a reputation as being rather difficult course. In order to appreciate and apply the principles of physical chemistry, students need to be familiar with the experimental foundation on which the theoretical principles originated are based. The successful application of the principles of physical chemistry requires students to have an intimate knowledge of the methods and experimental techniques used in the lab. Many of the traditional experiments in the laboratory course need to be upgraded with more sophisticated equipment and devices to stay in step with modern physical chemistry.

This is necessary in order to develop student’s research aptitude and boost interest in this day of cell phones, mp3 players, and i‐pods. In our work, the equipment has been updated and the design improved for the phase equilibrium experiment “Vapor pressure of a pure liquid” in which the heat of vaporization (∆Hvap) of the liquid is determined. The alcohol and mercury thermometer has been replaced by an Omega digital thermometer with a K‐type thermocouple sensor. The water aspirator used to adjust the pressure inside the bulb has been replaced with a portable Welch GEM vacuum pump, which weighs less than 20 lbs. A digital manometer has been substituted for the U‐shaped mercury manometer that is mounted against a meter stick. The upgraded experimental apparatus was used to determine the ∆Hvap of water and toluene. The heat of vaporization of the former and latter substances was 41.3 kJ/mol and 1.21 kJ/mol respectively, which deviated from the literature values by 1.23% and 7.85% respectively.

These computed values were acquired by fitting the plot of ln P (torr) vs. 1/T(K) using as few as eight measurements using Excel or KaleidaGraph. The data collection was fast and efficient using this experimental design and the class enthusiasm increased towards the course.

“Poly(Anhydride‐Ester)/Antimicrobial Blends For Localized Drug Delivery”

Michelle L. Johnson, Kathryn E. Uhrich*

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Rutgers, the State University of New Jersey, Department of Chemistry and Chemical Biology, Piscataway, NJ

Abstract

A polymer‐based drug delivery system has been developed for implantation into the pockets formed in the periodontium (gum tissue) during the progression of periodontal disease. The system is a potential adjunct treatment for the bacterial infection, inflammation, and pain associated with periodontal disease. The system may reduce the need for systemic antimicrobial administration, and concern with patient compliance will be alleviated. The salicylic acid‐based polymer used in the studies hydrolytically 227

POSTER ABSTRACTS degrades to release salicylic acid, which is a non‐steroidal anti‐inflammatory agent (NSAID). The three antimicrobials (chlorhexidine, clindamycin, and minocycline) were physically admixed at 10 % by weight into the polymer matrix by a melt mixing method chosen according to their octanol/water partition coefficient (logP) values and their effectiveness in treating periodontal disease. Differential scanning calorimetry (DSC) was used to characterize the blends. In vitro drug release of salicylic acid from the polymer matrix and for each physically admixed antimicrobial was simultaneously monitored by high pressure liquid chromatography (HPLC) during the course of polymer degradation.

The polymer glass transition temperature (Tg) decreased indicating the antimicrobials act

as plasticizers within the polymer matrix. The release rate of salicylic acid from the polymer is not significantly influenced by the antimicrobials indicating nearly zero‐order release. However, the antimicrobial release decreased with increasing hydrophobicity.

The polymer/antimicrobial blends were able to concurrently release salicylic acid and each antimicrobial. The blends are being investigated to treat infections associated with periodontal disease, but may also promote tissue regeneration.

PhD in APPLIED CHEMISTRY The program is focused on several areas of applied chemistry including polymer chemistry, biochemistry, environmental chemistry, hydrogen storage, spectroscopy, etc. Faculty members are engaged in a variety of cutting-edge research projects. The department has a wide selection of modern instruments and equipment to support teaching and research.

For admission to this program, applicants must show evidence that they have earned the bachelor’s degree in chemistry, or a related field, at an accredited college or university and possess the ability to carry out graduate work of high quality. Applicants should have a minimum cumulative undergraduate grade point average of 3.0 (on a 4-point scale) and a scholastic average of 3.00 in their undergraduate major. If a student has a GPA less than 3.0, the student may be conditionally recommended for acceptance into the program with the recommendation of the Chemistry Department PhD program committee. Applicants must submit a completed application package that includes the application, the application fee, three letters of recommendation by persons who are acquainted with their potential for graduate study in their discipline, one (1) official transcript from each college or university attended, and a completed essay. Official scores on the Graduate Record Examination (GRE) or its equivalent will be required during matriculation. The test scores must not be more than five years old. For foreign students, the official score of TOEFL will be required. The test score must be no more than 2 years old.

The best way to find out more about us is to visit our campus. To arrange a campus visit, contact the Chemistry Department at 302-857-6530. For application materials contact the Office of Graduate Admissions or go to the DSU website: http://chem.desu.edu 228

NATIONAL CONFERENCE COMMITTEE Conference Chair Sandra K. Parker The Dow Chemical Company

Core Team Chairs Meeting Planner & Site Logistics Tim Oâ&#x20AC;&#x2122;Neill Leading Edge Marketing and Planning, Inc. Local Chapter Zachary Cross

Secondary Education Linda Davis Committee for Program Action Services (CAPS)

Marketing & Communication Lisa Coster Coster Communications

Conference Participation Ella L. Davis

Finance Lolita Grant, CPA National Treasurer

New Business Development Dale Mack Morehouse School of Medicine

Workshops/Symposiums/Technical Programs/Student Support Rebecca Tinsley, PhD & Sharon Kennedy, PhD Colgate Palmolive

Ex-Officio Member Victor McCrary, PhD ~ National President The Johns Hopkins Applied Physics Laboratory

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NATIONAL CONFERENCE COMMITTEE Sub-Committees Meeting Planning/Site Logistics Tim Oâ&#x20AC;&#x2122;Neill, Meeting Planner

New Business Development Dale Mack, Chair Morehouse School of Medicine

Leading Edge Marketing and Planning, Inc.

Patty Blanchard, Onsite Staff

Cassandra Broadus Morehouse School of Medicine

Leading Edge Marketing and Planning, Inc

La Rue Forrester, Onsite Staff

Darrell Davis

Leading Edge Marketing and Planning, Inc

Committee for Program Action Services (CAPS)

Sandra Graff, VIP Coordinator Retiree, AT&T

Victor McCrary, PhD Johns Hopkins Applied Physics Laboratory

Robert Murff Retiree, Eli Lilly

Printing/Publishing Tony Dent, PhD, Chair Retiree, PQ Corporation

NOBCChE Local Chapter Delaware Valley/New York/New Jersey

Marketing/Public Relations Lisa Brusio Coster M.A., Chair Coster Communications, Ltd

Zachary Cross, Chair Esther Browne Rohm & Haas

Christine D. Davis Graphic Designer

Connell Cunningham, PhD Rohm & Haas

James Grainger, PhD Center for Disease Control & Prevention

Emmanuel Dada, PhD FMC

Kimberly Jackson Procter & Gamble

Tony Dent, PhD Retiree, PQ Corporation

Simon K. Shannon, PhD Corning, Inc.

Marquita Qualls, PhD GlaxoSmithKline

Steven Thomas, Webmaster Michigan State University

David Robinson GlaxoSmithKline

Keith Williams, PhD Wayne State University

Lamont Terrell, PhD GlaxoSmithKline

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NATIONAL CONFERENCE COMMITTEE Local Chapter, cont.

Wayne Thompson

Professional Development Workshops Denise Barnes PhD National Science Foundation

Charles Williams Plastomer Technologies

Sharon Barnes The Dow Chemical Company

Student Programs Sharon Kennedy PhD, Chair Colgate Palmolive

Marquita Qualls PhD GlaxoSmithKline Corporation

Rebecca Tinsley PhD, Co-Chair Colgate Palmolive

Guest Speakers William Jackson, PhD, Chair University of California, Davis

Sean Gant, Natâ&#x20AC;&#x2122;l Student Rep University of Michigan Awards Chris Hollinsed PhD, Chair American Chemical Society

Technical Workshops & Symposiums Rebecca Tinsley PhD, Co-Chair Colgate Palmolive

Malika Jeffries-El, PhD Iowa State University

Sharon Kennedy PhD, Co-Chair Colgate Palmolive

Alicia Clay Jones, PhD National Institute of Standards & Technology

Mike Harris PhD Purdue University

Alison Williams, PhD Princeton University

Dale Wesson PhD Florida A&M University

Edward Yokley, PhD Stormrider Technologies Health Symposium Ron Lewis PhD, Chair Pfizer Inc., PGRD La Jolla

Proceedings Tommie Royster PhD, Chair Eastman Kodak Company

Steven Thomas Michigan State University

Dinah Jordan Princeton University

Michael Edwards Indiana University

Alison Williams PhD Princeton University

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NATIONAL CONFERENCE COMMITTEE Jesse Edwards PhD Florida A&M University

Henry Beard Temple University

Conference Registration Ella L. Davis- Chair

Teachers Workshop Linda Davis, Chair Committee for Action Program Services (CAPS)

Brenda Brown San Diego Unified School District

Sheila Turner Marine Corp Recruit Depot

Celeste Tidwell San Diego Unified School District

Joyce Chesley-Dent Retiree, Federal Government

Shirley Hall Retiree, San Diego City Government

Jennifer Stimpson Dallas Independent School District

Dorothy Haynes Rohm and Haas Company

Science Bowl/Science Fair Sherine Obare, PhD, Chair Univ. of North Carolina at Charlotte

Henry Beard Temple University

Troy J. Corley, Co-Chair Mecklenburg County Health Department

Felecia Barnes-Beard Rohm and Haas Company

Kiana Hamlett Drug Enforcement Administration

Charlene Trader Rohm and Haas Company

John Harkless, PhD Howard University

Career Expo Darrell Davis, Chair Committee for Action Program Services (CAPS)

Gloria MaGee, PhD Xavier University of Louisiana

Rasheda Weathers Drug Enforcement Administration

Jennifer Stimpson Dallas Independent School District

Harmona Epps

Sheila Turner Marine Corp Recruit Depot

Committee for Action Program Services (CAPS)

Marcia L. Thomas The Dow Chemical Company Ramona Gray Merck Company

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LSAMP COMMUNITY OF • Science • Technology • Engineering & Mathematics •

TSU H‐LSAMP PERSONNEL Dr. Bobby Wilson, Project Director and L. Lloyd Woods, Distinguished Professor of Chemistry Dr. Willie Taylor, Associate Director and Professor of Mathematics Ms. Michelle Tolbert, Program Coordinator Texas Southern University 3100 Cleburne Street Houston, Texas 77004 Phone: (713) 313-4278 Fax: 713-313-1999 Website: www.em.tsu.edu/LSAMP Email: LSAMPScholarship@tsu.edu

Texas Southern University LSAMP SCHOLARS

Desmond Adamu • Spence Aneike • Dalton Baltimore • Blas Becerra • Nytarsha Brown • Naudaushia Burton • Laquantii Calligan • Kristina Casmire1 • Noe Cervantes •Allan Chambers • Jonathan Charles • Christopher Crane • Darolyn Flags • Tywanisha Fleming • Erica Fruge • Ashley Garner • Chelsea Givens • Ashley Guillory •Jamie Handy • Bettina Harris • Chelsea Harris • Jordan Harris • Michael Harris • Laquisha Harris • Shanita Johnson • Ameenah Kegler • Kelisha Kuykendall • Mia Lander •Felipe Laynez • Stephanie Lopez • Nchekwube Mbamalu • Joel McEwen • Loucrea McKinzie • Apollonia McMillian • Jose Mejorado • Leticia Mendez • Brandon Mikell • Jeremy Miller • Kanetra Moses • Alicia Newman • Edidiong Obot • Ngwanma Ogbonna • Martin Perrusquia • Laquanta Perry • Nathanael Pierce • Jamail Plumber • Jessica Poole • Lizette Ramirez • Jesus Rodriguez • Kristen Saunders • Bobby Scott • Cynthia Sidoa • Eric Sloan • Tera Slone • Jessica Smith • Shelly Smith • Alicia Stephens • Candace Thomas • Shayla Thomas • Helen Ubanyionwu • Samuel Ubanyionwu • Fortune Usoro • Felisha

FUTURE ANNUAL CONFERENCE SITES AND DATES

2009 Renaissance Grand Hotel St. Louis, Missouri April 13 ‐ 18, 2009

2010 Marriott Marquis Atlanta Downtown Atlanta, Georgia March 29 ‐ April 3, 2010

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Is Proud To Be One of The Sponsors for

The 35th Annual Conference of The National Organization for The Professional Advancement of Black Chemists and Chemical Engineers

We Innovate Healthcare

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Awards Dinner Entertainment ‐ BOBBI HUMPHREY ‐ ʺFIRST LADY OF FLUTEʺ She has been named “First Lady of the Flute” by the critics and listeners alike and, from the accomplishments in her musical career, deservedly so.

For three decades, Bobbi Humphrey has been playing her special brand of music to audiences around the world. Her professional career began in 1971 when she was the first female signed to Blue Note Records.

Certainly a lady playing a flute must have seemed something of a novelty then. Ms. Humphrey proved, however, she was not just a “first” or novelty, but a considerable talent. For in 1973, her LP, Blues and Blues was not only a huge commercial success, but established a strong cross‐

over market for her. Also, in 1973, she was invited to the prestigious Montreux International Music Festival in Switzerland where she was acclaimed “the surprise hit of the festival”. Since then Ms. Humphrey has continuously proved her sustaining power, for today she is the only successful female urban‐pop flutist on the scene. Further proof is the fact that she was acclaimed “Best Female Instrumentalist” (1976 and 1978 to both Billboard and Record World, and “Best Female Vocalist” in Cashbox. This was certainly a milestone for any instrumentalist.

Born and raised in Texas, Humphrey’s training on the flute began in high school and continued through her years at Texas Southern University and Southern Methodist University. It was there that Dizzy Gillespie spotted her when he served as a judge in a school‐wide competition. With Gillespie encouraging her to pursue a career in New York City, Humphrey wrote a letter to the Apollo Theatre and received an invitation to perform on its Amateur Night. With this, she found her “spot” in the music industry. Between 1971 and 1976, Bobbi recorded six albums for Blue Note Records. 1977 was another big year for Humphrey. For the third consecutive year she was voted “Best Flutist” in Ebony Magazine Reader’s Poll. She was signed to Epic Records. She was invited back to the Montreux Music Festival., and honored with the Key to New Orleans. It was not only a year of musical growth but of commercial expansion as well, because in 1977 Humphrey formed Bobbi Humphrey Music Company to publish her compositions as well as composers. She also formed Innovative Artist Management to handle her business affairs.

Ms. Humphrey has received numerous awards and citations for her music. These awards have included the keys to cities for the United States and a Congressional Appointment to the Community Advisory Committee.

Also, she has received various awards for her business accomplishments and high ethics. However, Humphrey’s longevity on the charts has been her greatest award. In her LP, “City Beat” remained on the Billboard Magazine Black Charts for sixteen weeks. She served as producer, wrote many of the songs and gathered some of her musical friends to share in the treat.

In 1990 her company, Bobbi Humphrey Music, Inc., signed a production agreement with Warner Bros. Records, in which she brought new artists to the label and produced new material. Her agreement with Warner Bros. followed her discovering, and bringing to the attention of Warner Bros. A&R executives, R & B vocalist Tevin Campbell.

Following the success of Bobbi Humphrey Music selling in excess of five million units of the Campbell records, Ms. Humphrey boldly launched her label, Paradise Sounds Records, in 1994. She recorded her first release “Passion Flute”, which was recently re‐released and continues to be one of her fans’ all‐time favorite recording.

The album’s concept is to showcase Bobbi Humphrey with a cool jazz setting; mostly at mid‐tempo: although there is a surprising uptempo version of her huge hit, “Harlem River Drive. There are also two original ballads in which Bobbi features the smooth singing of D’wayne Whitehead. Another song features two great artists and friends of Bobbi, Gwen Guthrie on vocal and Ralph MacDonald on percussion. From the first track, “Steppin’ Out” which features Bobbi’s flute on a hauntingly smooth, yet strong hook, to the last track, “Rainbows”, a soaring ballad, her passionate and pure flute playing is ever present. In “Passion Flute”, her fans old and new will surely have a greater passion for Bobbi Humphrey.

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2009 NOBCChE Annual Conference April 13 - 18, 2009 See you in St Louis?

Renaissance Grand Hotel Save The Dates!

For more information, contact Ms Sandra Parker, nobccheconf@aol.com or visit www.nobcche.org