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Temporomandibular Disorders: A Translational Approach From Basic Science to Clinical Applicability 1st Edition Henry A. Gremillion
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Series Editor Foreword
To paraphrase Rodney Dangerfield, some hormones get no respect. Although the existence of prolactin in animals has been known since at least the 1930s, the debate about its presence in humans was not settled until the 1970s, when reliable assays that allowed us to distinguish prolactin from growth hormone were developed.
During the last five decades, our knowledge about prolactin has accumulated at a rapid pace. This hormone was found to be associated with some of the most frequently encountered pituitary disorders in women and men. Prolactin excess or, less commonly, deficiency can produce significant symptoms and sometimes may signal a life-threatening condition.
The volume, edited by Nicholas A. Tritos and Anne Klibanski, takes us on a remarkable journey focused on prolactin, starting with its history, then moving to anatomy, physiology in both animals and humans, molecular biology, and clinical aspects of prolactin-related disorders.
An international group of authors produced an extraordinarily well-written monograph, which not only contains the most up-to-date information on its subject, but also is a pleasure to read. This book will be useful to all those interested in pituitary biology, including students of biology and medicine and physicians in multiple specialties.
I hope you enjoy the journey!
New York, NY, USA
Leonid Poretsky,
MD
Preface
Our understanding of the role of prolactin in health and disease has continued to expand over the past several decades. In addition to its critical role in reproduction and lactation, animal studies have suggested that prolactin may be involved in a host of metabolic processes, which have yet to be established in humans. Prolactinsecreting pituitary tumors are the most common pituitary tumor phenotype. Prolactin disorders cause substantial morbidity and are quite diverse in etiology and management.
The purpose of this volume is to review our knowledge of both basic and clinical aspects of prolactin and help bridge gaps in existing literature in the field. Leading experts from basic sciences and clinical medicine have contributed a series of outstanding chapters that span the spectrum of prolactin-related literature. As such, the goal of this book is to provide information that should be of interest to a diverse audience, including basic scientists, clinical investigators, and clinicians from several specialties, including specialists in endocrinology, neurosurgery, radiation oncology, and neuro-oncology.
We are deeply indebted to an exceptional cadre of contributors who have authored a series of outstanding chapters in their respective fields. We hope that the present volume will become a valued guide to scientists and physicians, both in training and in practice, who wish to obtain current, in-depth information on this exciting and expanding field.
Boston, MA, USA
Nicholas A. Tritos Anne Klibanski
Ronald M. Lechan, Knarik Arkun, and Roberto Toni
3 Prolactin Assays and Regulation of Secretion: Animal and Human Data
Nadine Binart, Jacques Young, and Philippe Chanson
Alexander Faje, Marcus A. Zachariah, and Brooke Swearingen
9 Prolactin and Pregnancy
Mark E. Molitch
Takara L. Stanley and Madhusmita Misra 11 Prolactinomas in Men
Dominique Maiter
12 Plurihormonal Adenomas
Artak Labadzhyan and Shlomo Melmed
13 Aggressive Prolactin-Secreting Pituitary Adenomas and Carcinomas
Dongyun Zhang and Anthony P. Heaney
Contributors
Knarik Arkun, MD Department of Anatomic and Clinical Pathology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
Nadine Binart, PhD Inserm U1185, Faculty of Medicine Paris Sud, University Paris-Saclay, Le Kremlin-Bicêtre, France
Marcello D. Bronstein, MD, PhD Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clinicas and Laboratory of Cellular and Molecular Endocrinology LIM-25, University of São Paulo Medical School, São Paulo, Brazil
Felipe F. Casanueva, MD Department of Medicine – Endocrinology, University Hospital of Santiago, Santiago de Compostela, Spain
University of Santiago, and Centro de Investigación Biomédica en Red ObesityNutrition, Santiago de Compostela, Spain
Department of Medicine, Santiago de Compostela University, Complejo Hospitalario Universitario de Santiago (CHUS), CIBER de Fisiopatologia Obesidad y Nutrición (CIBERobn), Instituto Salud Carlos III, Santiago de Compostela, Spain
Philippe Chanson, MD Inserm U1185, Faculty of Medicine Paris Sud, University Paris-Saclay, Le Kremlin-Bicêtre, France
Service d’Endocrinologie et des Maladies de la Reproduction, Assistance PubliqueHôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre Le Kremlin-Bicêtre, Le Kremlin-Bicêtre, France
Alexander Faje, MD Department of Endocrinology, Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA
Andrea Glezer, MD, PhD Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clinicas and Laboratory of Cellular and Molecular Endocrinology LIM-25, University of São Paulo Medical School, São Paulo, Brazil
Anthony P. Heaney, MD, PhD Departments of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Department of Medicine and Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Nelson D. Horseman, MS, PhD Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH, USA
Artak Labadzhyan, MD Pituitary Center, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Ronald M. Lechan, MD, PhD Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
Dominique Maiter, MD, PhD Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc – Université catholique de Louvain, Brussels, Belgium
Shlomo Melmed, MB, ChB, MACP Pituitary Center, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Madhusmita Misra, MD, MPH Department of Pediatrics, Harvard Medical School, Boston, MA, USA
Pediatric Endocrine Unit and Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA
Mark E. Molitch, MD Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern Medicine, Chicago, IL, USA
Ignacio Bernabeu Morón, MD Department of Medicine – Endocrinology, University Hospital of Santiago, Santiago de Compostela, Spain
Lisa L. Morselli, MD, PhD Department of Internal Medicine, Division of Endocrinology, University of Iowa Carver College of Medicine, Iowa City, IA, USA
Department of Internal Medicine, Division of Endocrinology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Janet A. Schlechte, MD Department of Internal Medicine, Division of Endocrinology, University of Iowa Carver College of Medicine, Iowa City, IA, USA
Department of Internal Medicine, Division of Endocrinology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Mildred Sifontes Dubon, MD Department of Medicine – Endocrinology, University Hospital of Santiago, Santiago de Compostela, Spain
Takara L. Stanley, MD Department of Pediatrics, Harvard Medical School, Boston, MA, USA
Pediatric Endocrine Unit and Neuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA
Contributors
Brooke Swearingen, MD Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA
Roberto Toni, MD, PhD Department of Medicine and Surgery, Unit of Biomedical, Biotechnological, and Translational Sciences, Section of Human Anatomy, RE. MO.BIO.S. Lab, Parma, Italy
Center for Sport and Exercise Medicine (SEM), University of Parma School of Medicine, c/o Maggiore Hospital, Parma, Italy Museum of Biomedicine and Historical Laboratory (BIOMED), University of Parma Museum Network System, Parma, Italy
Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
Rocío Villar Taibo, MD Department of Medicine – Endocrinology, University Hospital of Santiago, Santiago de Compostela, Spain
John AH Wass, MA, MD, FRCP Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK
Jacques Young, MD, PhD Inserm U1185, Faculty of Medicine Paris Sud, University Paris-Saclay, Le Kremlin-Bicêtre, France
Service d’Endocrinologie et des Maladies de la Reproduction, Assistance PubliqueHôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre Le Kremlin-Bicêtre, Le Kremlin-Bicêtre, France
Marcus A. Zachariah, MD, PhD Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA
Dongyun Zhang, PhD Departments of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Chapter 1 History of Prolactin Disorders
John AH Wass
Medical Therapy
Medical therapy for prolactinoma began with the dopamine agonist bromocriptine and has now moved on to cabergoline, a longer-acting dopamine agonist. Surgery and radiotherapy are occasionally indicated in the treatment of prolactinoma. Prolactinoma, besides being the commonest of the pituitary tumours, has a recent and very rich history.
Introduction
Prolactinoma is the most recent of the characterised pituitary tumours to be described in detail. Hippocrates (above) may have been the first to describe prolactinoma. Galen, who was the most important physician of the Greco-Roman period (A.D. 130–200), had an enormous influence on medicine through the middle ages and was both a prolific writer and a keen experimental physiologist but got endocrinology wrong and thought the ductless glands were filters through which the fluid portions of the blood were sieved. Thus, he thought the thyroid lubricated the larynx and that the animal spirit was formed in the brain with the waste products flowing to the base of the brain, down the pituitary stalk and so to the pituitary gland. From this ‘phlegmatic glandule’, the waste products were passed by ducts through the sphenoid and ethmoid bones to the nasopharynx where they emerged as ‘pituita’ or nasal mucus. This view of the pituitary was held for 1500 years until the existence
J. AH Wass (*)
Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK
N. A. Tritos, A. Klibanski (eds.), Prolactin Disorders, Contemporary Endocrinology, https://doi.org/10.1007/978-3-030-11836-5_1
J. AH Wass
of communication between the ventricles of the brain and the nasal pharynx was disproved as ‘pituita phlegm’.
This chapter will deal with the history of prolactin and its differentiation from growth hormone and the history of the discovery of its actions, its gene and receptors. It will also deal with assays for prolactin and the regulation of prolactin by the hypothalamus. It will deal with prolactin in males. Furthermore, the history of the clarification of symptoms of prolactinoma in both women and men is set out together with the history of medical treatment for prolactinoma, the effects of medical treatment on pituitary size as well as surgical and radiotherapy treatments of prolactinoma.
Did Mary Tudor of England Have a Prolactinoma? [1]
Mary Tudor (Queen Mary 1 of England) was the eldest child of Henry VIII by his first wife Catherine of Aragon.
In brief, she had a difficult life with paternal deprivation. She had episodes from the age of 19 of amenorrhoea and also complained of headaches. Her vision was impaired. During her two episodes of assumed pregnancy, she, in addition to amenorrhoea, had swelling of the abdomen and mild secretion from the breasts. She died at age 42.
While amenorrhoea and even galactorrhoea can occur with pseudocyesis, severe headaches and impairment of vision do not. It may be that Queen Mary had a prolactinoma, but it is unlikely to be known because she is buried in Westminster Abbey under the tomb of Queen Elizabeth 1, her half-sister, and it is therefore very unlikely for her tomb to be disturbed. It is nevertheless an interesting speculation.
The Discovery of Human Prolactin
Although prolactin was discovered in the early 1930s in sheep, cows and birds, no human form had been found because it was thought to be identical to growth hormone [2]. In fact, prior to 1970, most endocrinologists doubted human prolactin even existed. Attempts to purify prolactin identified only growth hormone. A search was begun for prolactin through protein synthesis studies using pituitaries from pregnant and postpartum monkeys. Proteins obtained in a radioactive peak were similar to, but not identical with, growth hormone by molecular weight and electrophoretic mobility. Evidence was then obtained confirming that in the human, pituitary prolactin and growth hormone synthesis could be distinguished using antibodies to human growth hormone or to sheep prolactin [2]. The final discovery of this hormone has had a major impact in endocrinology and reproductive medicine.
Prolactin is mainly produced by pituitary lactotrophs and is tonically inhibited in the hypothalamus by dopamine. There are multiple extrapituitary sites of prolactin secretion, but its primary function is to enable breast milk production through prolactin receptors which are also found in many other tissues.
The major isoform is 23-kDa prolactin which acts via a membrane receptor, the prolactin receptor, which is a member of the cytokine superfamily. As will be discussed below, it is clear that high levels of prolactin interfere with reproductive function in humans.
In 1915 Gaines demonstrated that the pituitary was important in lactation [3].
In 1928 Stricker and Grueter observed that lactation could be produced in ovariectomised pseudopregnant rabbits by the administration of anterior pituitary extracts [4].
In the late 1920s, it was found that pituitary extracts induce milk secretion. Riddle [5] found that the substance which they called prolactin could be differentiated from the known growth- and gonad-stimulating substances. John Hunter in 1786 had described pigeon’s milk secreted by the crops of breeding birds [6]. In these experiments, it was found that prolactin stimulated milk production by guinea pig mammary glands and a milklike substance from the crop sacs of pigeon and doves was produced, thus giving rise to the pigeon crop sac assay for prolactin. Furthermore, it was discovered that hypophysectomy stops lactation [7]. Although in the ensuing years prolactin was characterised in sequence in other species, the high lactogenic activity of even very highly purified preparations of growth hormone was impossible to separate from human prolactin using the relatively crude pigeon crop assay. Several diseases however suggested that the two hormones were separate. Most patients with pituitary tumours in which there was amenorrhoea or galactorrhoea had these cardinal features but not features of acromegaly. Furthermore, patients who had growth hormone deficiency from birth were able to lactate.
David Kleinberg (Fig. 1.1) and Andrew Frantz [8] developed an in vitro bioassay which was highly sensitive. They used unextracted human plasma to look at breast tissue fragments from pregnant mice incubated in organ culture, and the sensitivity of the assay was 5 ng/ml. All 14 of the nursing mothers they studied had elevated levels of circulating prolactin in this assay, and growth hormone was in the low normal range in all of these subjects. They also showed that psychoactive drugs of the phenothiazine series elevated prolactin. Furthermore, when growth hormone antisera to human growth hormone were pre-incubated with plasma from each of these subjects there was no significant inhibition of prolactin activity. They concluded that growth hormone and human prolactin were separate molecules with little if any immunological cross-reactivity. Further, they concluded that there were different physiological mechanisms for their release. Shortly after this, a radioimmunoassay for human prolactin was developed which could measure prolactin levels in normal individuals permitting the entire sequence of human prolactin to be shown. This therefore was the last anterior pituitary hormone to have its sequence described [9]. We know that the composition of the human prolactin is similar to that of bovine prolactin and porcine prolactin. Human prolactin’s composition resembles that of growth hormone being rich in acidic and hydrophobic residues.
Shortly after the report of the bioassay for prolactin, Noel described the release of prolactin as well as growth hormone during surgery and other conditions of stress [10]. They showed a fivefold increase with major surgery. They also showed significant elevation of prolactin levels after insulin-induced hypoglycaemia as well as a rise in some women though not in men following sexual intercourse.
Cell of Origin
We know that prolactin is made by the pituitary lactotrophs and in a normal human pituitary these comprise 15–25% of the total number of cells. This is similar in both sexes and does not change significantly with age. During pregnancy however and subsequent lactation, lactotroph hyperplasia is observed because of lactotroph proliferation. This hyperplastic process involutes within several months after delivery but breastfeeding retards this progress. This stimulatory effect of pregnancy on the
Fig. 1.1 David Kleinberg
J. AH Wass
lactotrophs is also true for prolactinomas, and we know that lactation may induce significant tumour growth in these circumstances.
Prolactin Action
Prolactin has a large number of different actions in many species including fishes, birds and mammals. These are very diverse including osmoregulation, growth, metabolic effects and actions related to reproduction. In humans, clearly, the primary physiological action is the preparation of the breast for lactation in the postpartum period.
Prolactin belongs to the somatotropins/prolactin (PRL) family, a large family of proteins that include growth hormone, placental lactogen and other prolactin-like hormones. The human prolactin gene is located on chromosome 6p22.2-p21.3 and consists of five coding exons, one non-coding exon and four introns. It is believed that prolactin, growth hormone and placental lactogen arose from duplication of a common ancestral gene about 40 million years ago. The entire prolactin locus in humans spans a region of about 10 kb.
The prolactin receptor belongs to the class 1 cytokine receptor superfamily, a family of transmembrane proteins that transduce signals following phosphorylation by cytoplasmic kinases. The human prolactin receptor gene is located on chromosome 5p14-p13.2 and consists of eight or nine coding exons and two non-coding exons.
Neuroendocrine Regulation
Geoffrey Harris (Fig. 1.2) in his influential monograph Neural Control of the Pituitary Gland thought that prolactin (lactogenic hormone) was controlled differently to the other adenohypophyseal hormones [11]. He showed that cutting the pituitary stalk did not abolish lactation.
The hypothalamus is the predominant regulator of prolactin secretion by inhibition through prolactin inhibitory factors which reach the pituitary via the hypothalamic portal blood vessels. Dopamine is the major pituitary prolactin-inhibiting factor, and a section or disruption of the stalk therefore leads to moderate increases of prolactin [12].
Dopamine in the 1950s was demonstrated to be the predominant inhibitory factor when pituitaries were transplanted below the renal capsule resulting in an elevation of prolactin, thus demonstrating the predominant inhibitory effect of the hypothalamus on prolactin secretion. The concentration of dopamine in the pituitary stalk plasma was enough to inhibit prolactin release [13]. Work with D2 receptordeficient mice subsequently showed the development of lactotroph hyperplasia and hyperprolactinaemia [14].
Thyrotroph-stimulating hormones and prolactin release have been shown to be caused by thyrotropin-releasing hormone (TRH). There are type 1 TRH receptors both in thyrotrophs and lactotrophs. Intravenously TRH causes a rapid rise in prolactin. In hypothyroidism, TRH synthesis is increased which results in hyperprolactinaemia which is corrected once euthyroidism is restored.
Actions of High Levels of Prolactin
Prolactin causes growth and development of the mammary gland, the synthesis of milk and the maintenance of milk secretion. Other hormones besides prolactin are involved. During pregnancy high concentrations of oestradiol and progesterone produced by the placenta together with high levels of prolactin and human placental lactogen promote proliferation of the lobular alveolar epithelium. After parturition, progesterone and oestrogen levels together with those of human placental lactogen decline, whereas prolactin levels rise. Lobular alveolar epithelium converts into secretory acini.
Fig. 1.2 Geoffrey Harris
J. AH Wass
Nonpubertal galactorrhoea may be present in normal women in around 5–10% in whom basal prolactin levels are normal in 90%.
Prolactin affects gonadotrophin secretion and has been shown to suppress LH pulsatility, and the mechanism of this has been recently demonstrated. This is caused by reduced hypothalamic expression of kisspeptin 1, and kisspeptin if given intraperitoneally restores hypothalamic GnRH and gonadotrophin secretion showing that kisspeptin 1 neurones have an importance in hyperprolactinaemic anovulation [15].
In normal men, the role of prolactin is less well defined, but in men with high prolactin levels, there is impotence and lowered libido. Galactorrhoea is reported in 10–20% of men with hyperprolactinaemia. This symptom does not occur in normal men, and around 25% of men with hyperprolactinaemia have impotence or infertility or both. The reason for this is decreased pulsatile gonadotrophin secretion which results in low or low-normal testosterone levels. Sperm counts and motility are also decreased in men with hyperprolactinaemia.
Drugs can interfere with prolactin secretion. Thus, dopamine antagonists result in hyperprolactinaemia, and some antidepressants including selective serotonin reuptake inhibitors may also have the same effect because of the importance of serotonin in neuroregulatory control of prolactin.
Medical Treatment of Hyperprolactinaemia
The first description of the successful treatment of galactorrhoea associated with a high prolactin level was by Besser et al. in 1972 [16]. He described in a small group of patients with inappropriate lactation associated with high prolactin levels as measured by a bioassay, patients in whom a number of characteristic symptoms were present including galactorrhoea and amenorrhoea in women and impotence in men. They used the ergot alkaloid bromo-ergocryptine to suppress prolactin levels. In the patients they described, galactorrhoea ceased, and normal periods resumed, and in men potency returned. S. Franks and Howard Jacobs confirmed the reduction in prolactin in patients with elevated levels of prolactin by bromocriptine [17], and many of these patients were shown to have pituitary tumours and the bromocriptine restored fertility.
Later studies by Thorner et al. in 1974 in a larger group of women and men with galactorrhoea and hypogonadism showed that treatment for between 2 and 28 months was effective and gonadal status became normal on treatment [18].
Earlier work by scientists at the pharmaceutical firm Sandoz following on a series of experiments at the Weizmann Institute of Science in Tel Aviv by Moses Shelesnyak had shown that ergometrine and ergot toxin could adversely affect ovum implantation [19]. The conclusion of the Tel Aviv group was that this was not acting at the level of the uterus but in the hypothalamus where it inhibited prolactin secretion. However, at that stage, there was no assay for plasma prolactin
J. AH Wass
and the findings were ignored. At Sandoz though, work was done on ergocryptine and ergocornine, and these compounds also proved to be active in the inhibition of implantation of the ovum. In the meantime, the structure of prolactin had been established and sensitivity immunoassays had been developed. Flückiger at Sandoz began the search for an ergot alkaloid that would be active by mouth to specifically inhibit prolactin. Success came in 1965 with the synthesis of an ergoline compound called bromocriptine which acted predominantly as a dopamine agonist without any effects on adrenergic and serotoninergic receptors. Thus, was developed one of the more important compounds to treat patients with prolactin disorders.
Another ergot derivative is cabergoline which is an ergot derivative and selective for D2 receptors and with a long duration of action, because of extensive enterohepatic recycling. In an important paper in 1994, this drug was shown to have less side effects than bromocriptine and greater efficacy [20]. Thus, in 459 patients with hyperprolactinaemia and amenorrhoea, cabergoline (0.5–1.0 mg weekly) was compared to bromocriptine (2.5–5.0 mg daily). Cabergoline vs. bromocriptine achieved normal prolactin levels in 83% vs. 59% of patients. There were also few side effects with cabergoline. Now cabergoline is the preferred drug because of its lower side effects and increased efficacy.
Pituitary Tumour Shrinkage
Pituitary tumour shrinkage with dopamine agonists in patients with prolactinomas was first documented in the late 1970s. It was known that there was an antimitotic effect of bromocriptine. In 1982 a number of reports suggested that tumour regression was due to lactotroph cell size reduction which was a reversible effect after withdrawal [21]. From the clinical point of view, 79% of macroprolactinomas reduced in size by at least 25% and 89% shrank to some degree. The majority of this was shown to occur in the first 3 months of treatment.
Surgery
Historically, surgical resection of prolactinomas was the preferred way of treating them before the advent of dopamine agonists. Nowadays, surgery in the treatment of prolactinoma is not often required except in patients who are resistant to or intolerant of dopamine agonists. This may provide helpful results. Several surgeons have reported their results and around 75% of microadenomas and 30% of macroadenomas are reportedly cured by surgery. Recurrence of hyperprolactinaemia may occur. Complications of transsphenoidal surgery, initially reported as infrequent, show a degree of hypopituitarism partly related, possibly, to the small size of the tumour in a proportion of patients.
Radiotherapy
Because of the excellent responses both to dopamine agonists and surgery, radiotherapy is very rarely indicated in patients with prolactinomas. Sometimes in resistant prolactinomas, radiotherapy may be indicated in patients with large tumours and to control growth in aggressive tumours, when tumour control is important. In the treatment of pure hyperprolactinaemia, only a minority of patients over 2–14 years (32%) are rendered normoprolactinaemic.
Summary
The story of the history of prolactinoma is fascinating. We have moved on from surgical treatment to highly effective medical treatment in the vast majority of patients.
References
1. Medvei VC. The illness and death of Mary Tudor. J R Soc Med. 1987;80(12):766–70.
2. Friesen HC, et al. The discovery of human prolactin: a very personal account. Clin Invest Med. 1995;18(1):66–72.
5. Riddle, et al. The preparation, identification and assay of prolactin-a hormone off the anterior pituitary. Am J Phys. 1933;105:191–216.
6. Medvei VC. A history of endocrinology. Lancaster: MTP Press; 1982. p. 197.
7. Allan H, Wiles P. The rôle of the pituitary gland in pregnancy and parturition: I. Hypophysectomy. J Physiol. 1932;75(1):23–8.
8. Frantz AG, Kleinberg DL. Prolactin: evidence that it is separate from growth hormone in human blood. Science. 1970;170:745–7.
9. Shome B, Parlow AF. Human pituitary prolactin (hPRL): the entire linear amino acid sequence. J Clin Endocrinol Metab. 1977;45(5):1112–5.
10. Noel GL, et al. Human prolactin and growth hormone release during surgery and other conditions of stress. J Clin Endocrinol Metab. 1972;35(6):840–51.
11. Harris GW. Neural control of the pituitary gland. Physiol Rev. 1948;28(2):139–79.
12. Grattan DR. 60 years of neuroendocrinology: the hypothalamo-prolactin axis. J Endocrinol. 2015;226(2):101–22.
13. Ben-Jonathan N, Hnasko R. Dopamine as a prolactin (PRL) inhibitor. Endocr Rev. 2001;22(6):724–63.
14. Bossé R, et al. Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. Neuron. 1997;19(1):127–38.
15. Skorupskaite K, et al. The kisspeptin-GnRH pathway in human reproductive health and disease. Hum Reprod Update. 2014;20(4):485–500.
16. Besser GM, et al. Galactorrhoea: successful treatment with reduction of plasma prolactin levels by brom-ergocryptine. Br Med J. 1972;3(5828):669–72.
17. Franks S, et al. Incidence and significance of hyperprolactinaemia in women with amenorrhea. Clin Endocrinol. 1975;4(6):597–607.
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18. Thorner MO, et al. Long-term treatment of galactorrhoea and hypogonadism with bromocriptine. Br Med J. 1974;2(5916):419–22.
19. Lee MR. The history of ergot of rye (Claviceps purpurea) III: 1940–80. J R Coll Physicians Edinb. 2010;40(1):77–80.
20. Webster J, et al. A comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea. Cabergoline Comparative Study Group. N Engl J Med. 1994;331(14):904–9.
21. Bevan J, et al. Dopamine agonists and pituitary tumor shrinkage. Endocr Rev. 1992;13(2):220–40.
Chapter 2 Pituitary Anatomy and Development
Ronald M. Lechan, Knarik Arkun, and Roberto Toni
Historical Anatomy
The most ancient suggestion of a pituitary gland in man can be traced to the Tantra Yoga, elaborated by the pre-Aryan, Dravidic culture and Aryan Brahmanic, Ayurvedic medicine of fifteenth to fifth centuries B.C. [1]. Although Vedic medical doctrine prohibited dissection of human cadavers, it recognized an “energy center” in the brain called ājñā chakra in ancient Sanskrit, believed to regulate consciousness and perception of “self.” This center was symbolized by two petals of the lotus flower, reminiscent of the two thalamic masses [2], and, possibly, the two lobes of the pituitary gland [1]. According to the Tantric anatomy, this region included numerous efferent channels (nerve fibers) called nadis [3], which we now recognize to contain the hypothalamic tuberoinfundibular system (for historical reviews, see [4–7]).
R. M. Lechan (*)
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
e-mail: rlechan@tuftsmedicalcenter.org
K. Arkun
Department of Anatomic and Clinical Pathology, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
R. Toni
Department of Medicine and Surgery, Unit of Biomedical, Biotechnological, and Translational Sciences, Section of Human Anatomy, RE.MO.BIO.S. Lab, Parma, Italy
Center for Sport and Exercise Medicine (SEM), University of Parma School of Medicine, c/o Maggiore Hospital, Parma, Italy
Museum of Biomedicine and Historical Laboratory (BIOMED), University of Parma Museum Network System, Parma, Italy
Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA
N. A. Tritos, A. Klibanski (eds.), Prolactin Disorders, Contemporary Endocrinology, https://doi.org/10.1007/978-3-030-11836-5_2
The first anatomical description of the pituitary gland on record, however, was during the second century A.D. by Galen of Pergamon. In Anatomicae Administrationes, he described a physical connection between the pituitary and infundibulum of the hypothalamic third ventricle and its association with a surrounding vascular network that he called “rete mirabilis.” He proposed this unique, arterial structure had a key role in the regulation of body energy, sensation, and impulse, which he referred to as “vital and animal spirits.” Galen was influenced by the ancient, Greek anatomist, Herophilus of Alexandria (third century B.C.), however, to whom he credited the discovery of the rete mirabilis [4, 5, 8, 9]. Although absent in humans, the rete mirabilis is a well-developed structure in a number of animal species (Carnivora, Cetacea, Edentata, and Ungulata) and equivalent to the suprahypophysial, circuminfundibular, and prechiasmal arteriolar-capillary plexus of man [4–6]. In De Usu Partium, the major treatise of Galenic physiology, the pituitary gland is described as a receptacle for brain “waste” in the form of mucus or phlegm (pituita in Latin) that accumulates in the third ventricle as a result of the “metabolism” of “body energy” at the level of the rete mirabilis. This material was proposed to drain along the hypothalamic infundibulum and “filtered” by the pituitary gland before exiting through the nasal cavities [4, 5]. Although now archaic in concept, it is of interest that evidence for brain paravascular channels that drain into sinus-associated dural lymphatics and perivenular lymphatics (so-called glymphatic system) have recently been described [8], re-energizing the Galenic concept of nasopharyngeal extracerebral transport of “metabolic impurities” from the central nervous system.
Galenic concepts dominated for several centuries as indicated by drawings of the pituitary gland and rete mirabilis by Leonardo da Vinci in 1508 (Fig. 2.1a, b), but he also provided the first detailed drawings of the anatomy of the human skull base. These included transverse and sagittal views of the cranial fossa, giving a detailed anatomical depiction of the association between the third ventricle/pituitary stalk and the cranial vault, facial bones, and nasal/oral cavities (Fig. 2.1c–e). During the same period, Johannes de’ Ketam published the superficial cranial projection of somatesthesia (Fig. 2.1f) in Man of Diseases (1491), corresponding to the frontal area where hyperalgesia occurs with stretching of the diaphragma sellae, as with a pituitary macroadenoma that extends into the suprasellar cistern [9]. In 1511, Michelangelo Buonarroti painted the fresco, Creation of Adam, on the ceiling of the Sistine Chapel, believed to be the first depiction of the hypothalamic-pituitary region (Fig. 2.1g, h) [4, 5].
It was not until the sixteenth century, however, that Berengario da Carpi in Isagoge Breves first challenged the Galenic concept of the pituitary gland as a basin that filtered cerebral waste products, based on his work with human cadavers, and described the sphenoid sinus as a route to the sella turcica [4, 5]. Shortly thereafter, Andreas Vesalius in Tabulae anatomicae sex (1538) described the venous drainage from the cranial vault, which recapitulates what we now recognize as the inferior and superior petrosal and sphenoparietal sinuses (Fig. 2.2a), and although demonstrated that the rete mirabilis originates from the internal carotid artery, surrounds the pituitary fossa, and then widens symmetrically and superiorly to vascularize the
R. M. Lechan et al.
Fig. 2.1 (a) Drawing of the base of the brain by Leonardo da Vinci depicting the rete mirabilis (arrow) surrounding the pituitary gland (PIT), likely the oldest image of this anatomical region. Note squat morphology of the temporal lobes and width of the encephalic mass, typical of ox anatomy as opposed to human anatomy where an elongated morphology of brain lobes prevails and the rete mirabilis is absent. (Royal Library at Windsor Castle, Courtesy of the Historical Library of the Museum of Biomedicine – BIOMED, University of Parma, Parma, Italy, partly modified) (b) Injection-corrosion cast of the bovine rete mirabilis around the pituitary (PIT) fossa (dotted arrow) and basilar (asterisk) arteries. Note the arrangement of blood vessels around the sella turcica is very similar to that depicted by Leonardo in his drawing. (Courtesy of Prof. Ferdinando Gazza, nineteenth-century collection of the Museum of Veterinary Anatomy, University of Parma, Parma, Italy) (c–e) Drawings by Leonardo da Vinci of the middle cranial fossa, sella turcica, and their anatomical relationships with the cranial vault and facial bones. These drawings were the oldest anatomical maps inspiring the surgical and later stereotaxic approach to tumors of the hypothalamic-pituitary complex at the end of the nineteenth century. (c, d) From O’Malley and de C.M. Saunders [157]; (e) Royal Library at Windsor Castle, Courtesy of the Historical Library of the Museum of Biomedicine – BIOMED, University of Parma, Parma, Italy (f) Johannes de’ Ketam’s depiction of sensory afferent projections (sensus communis, red rectangle) in the median supraorbital, frontal region in Man of Diseases. (Modified from Premuda L. Storia dell’Iconografia Anatomica. Ciba Edizioni, Ciba-Geigy, 1993, ISBN 88-7645-107-2, p. 65.) (g) Detail from the fresco, Creation of Adam, by Michelangelo Buonarroti. Red arrow points to a limb of one of the angels. (h) Contour of fresco in (g) is reminiscent of a midline sagittal section of the human brain. Limb of the angel (yellow arrow) represents the pituitary stalk. ((g, h) Adapted from [158])
R. M. Lechan et
Fig. 2.2 Drawings of Andreas Vesalius. (a, b) Plates from Tabulae anatomicae sex depicting (a) anatomy of the venous vertebral and internal jugular systems and the common facial vein. Note the X-shaped, venous pattern at the center of the image (blue dotted circle) fed by six, symmetrical branches of the internal jugular vein reminiscent of the distribution of the inferior and superior petrosal and sphenoparietal sinuses around the cavernous sinus. (b) The arterial, vertebral (dorsal vessels) and common carotid (ventral vessels) systems. The rete mirabilis has central opening where the pituitary gland would be located (red asterisk) and fed by the internal carotid artery. Note that the rete mirabilis widens symmetrically and superiorly to vascularize the suprahypophysial, hypothalamic area (corresponding to the red arrowheads). (From [5, 9], partly modified.) (c–f) Plates from the seventh book of De Humani Corporis Fabrica. (c) Enlarged view of the pituitary (A) showing the hypothalamic infundibulum and ducts comprising the foramen lacerum and superior orbital fissure. (d) Anatomical relationships between the infundibulum (e), dural diaphragma sellae, internal carotid arteries, and oculomotor and optic nerves. (e) Enlarged view of the pituitary (E) surrounded by the rete mirabilis arising from branches of the internal carotid artery. (f) Detailed view of the association between the pituitary (A), carotid arteries, and rete mirabilis. (Partly modified from [5, 9]) (From the BIOMED Museum, University of Parma)
infundibulum and hypothalamic floor, he erroneously reported that it was present in man (Fig. 2.2b). Subsequently, in De Humani Corporis Fabrica (1543), he detailed the anatomical relationships between the pituitary gland and the hypothalamic infundibulum, diaphragma sellae, internal carotid arteries, and oculomotor nerves and, although now denying the presence of the rete mirabilis in man, held fast to the Galenic dogma by describing bony ducts of the cranial base he believed to drain brain mucus (Fig. 2.2c–f). The contemporary of Vesalius, Gabriele Fallopius,
similarly argued against the presence of the rete mirabilis in man, but it was not until the seventeenth century that Thomas Willis raised the possibility in Cerebri Anatome that “humors” from blood perfusing the ventral surface of the brain are carried to the pituitary gland, unwittingly anticipating current concepts of releasing and inhibiting factors for adenohypophysial regulation [4, 5]. The Galenic idea that the pituitary gland filters brain secretions into the nose was also criticized by Konrad Victor Schneider during the same period in Liber Primus De Catarrhis (1660), showing that the cribriform plate of the ethmoid bone was impervious to drainage from the central nervous system, and by Willis’ assistant, Richard Lower, in his 1670 Tractatus de Corde, observing that the infundibular connection to the pituitary gland was filled with a gelatinous substance that would obstruct the possibility of mucous percolation from the third ventricle into the gland (see [6] for historical review).
Further advances were made in the eighteenth century by the French clinician and anatomist, Joseph Lieutaud, in Essais Anatomique (1742), who introduced the term “pituitary stalk” (la tige de la glande pituitaire) and described stalk vessels we now recognize as part of the portal circulation. In 1767, Luigi Galvani in Disquisitiones Anatomicae Circa Membranam Pituitariam showed that mucus passing through the nostrils originates from glands in the nasal mucosa and not the pituitary [10], and in 1791 Samuel Thomas von Sömmerring coined the term “hypophysis” in Hirnlehre und Nervenlehre [5]. However, it was not until the late in the nineteenth century and throughout the twentieth century that a new renaissance in the understanding the anatomy and importance of the pituitary gland was begun, coincident with the development of new and powerful histochemical and molecular techniques, and continues into the present century. Included was work by Santiago Ramón y Cajal in 1894 using the Golgi’s silver impregnation technique to elucidate the connection between the hypothalamus and posterior pituitary (supraoptic-hypophysial tract), the discovery of hypothalamic neurosecretion by Ernst Scharrer in 1928, the finding by Popa and Fielding in 1930 of an interconnection between the pituitary and hypothalamus through the “hypophyseo-portal vessels” (although misinterpreted as blood flowing from the pituitary upward to the hypothalamus), evidence by Harris and Green between 1935 and 1955 that the blood flow in portal vessels was from the hypothalamic median eminence to the pars distalis of the pituitary gland and that electrical stimulation of the hypothalamus was ineffective in eliciting a pituitary response if the pituitary stalk was severed, and descriptions of the neurosecretory nature of the neurohypophysis by Wolfgang Bargmann in 1949 using the Gomori’s histochemical method [11] (see also [6] for historical review). Many advancements have been made since, and those relevant to the current understanding of the anatomy of the pituitary gland are alluded to in the following sections. A timeline of major, historical breakthroughs in elucidation of the functional anatomy of the mammalian pituitary gland is summarized in Table 2.1.
R. M. Lechan et al.
Table 2.1 Timeline of major, historical breakthroughs in elucidation of the functional anatomy of the mammalian pituitary gland
1500–500 B.C Tantric Yoga and Vedic medicine locate an energy center at the level of the thalamic-pituitary area
II century A.D
Galen describes the rete mirabilis around the pituitary considered a filter for brain mucous to the nasal cavities
1489–1511 Leonardo da Vinci and Michelangelo Buonarroti paint the pituitary gland, rete mirabilis, and possibly a brain section with the pituitary stalk
1521–1523 Berengario da Carpi denies the existence of the rete mirabilis
1543 Andreas Vesalius publishes the drawings of the hypothalamicpituitary unit, rete mirabilis, and pituitary venous drainage as currently known for petrosal sampling
1561 Gabriele Fallopius confirms the absence of the pituitary rete mirabilis in humans
1791 Sömmerring introduces the term “hypophysis”
1894 Santiago Ramón y Cajal describes the supraoptico-hypophysial tract in rats using the Golgi’s silver impregnation method
1928 Ernst Scharrer describes “glandular cells” in the fish hypothalamus (concept of “neurosecretion) using standard histologic techniques
1930 Popa and Fielding discover the pituitary portal system
1938 Feyrter identifies “clear cells” in the anterior pituitary using the tartaric acid-thionin staining as a marker of the diffuse endocrine system later described by AGE Pearse
1935–1955 Harris and Green demonstrate in anesthetized rats that blood in the portal vessels flows to the pituitary, and this vascular link is critical to the hypothalamic control of pituitary secretions
1664 Thomas Willis argues that humors out of the brain base may be carried to the pituitary gland
1660–1670 Schneider and Lower reject the Galenic idea that the pituitary gland filters brain secretions to the nose
1742 Lieutaud discovers vessels in the pituitary stalk connected to those of the pituitary gland
1767 Luigi Galvani shows that mucus passing through the nostrils originates from mucous glands of the human nasal mucosa and not from the pituitary gland
1949 Wolfgang Bargmann describes the posterior pituitary using the Gomori’s chrome alum hematoxylin-phloxine stain
1964 János Szentágothai defines the hypothalamic origin of the tuberoinfundibular tract in rats, and Kjell Fuxe shows its entire course using the Falck-Hillarp histochemical technique for monoamines
1969–1970 Yoshimura et al. show that mice pituitary chromophobes may behave like pituitary stem cells, and Nakane provides ultrastructural bases for paracrine interactions in the pituitary gland
2009 Garcia-Lavandeira et al. identify stem cells/progenitors in the marginal zone of the adult human pituitary gland
Macroscopic Anatomy
Landmarks of the Sellar Region
The pituitary gland lies in the central part of the sella turcica (pituitary fossa), a saddle-shaped groove in the endocranial, superior surface of the sphenoid bone corresponding to the median part of the middle cranial fossa (Fig. 2.3a). On a lateral skull projection, the sella and pituitary lie 5–6 cm anterior to the point of the orthogonal intersection between Frankfurt horizontal plane and a vertical line descending from the vertex of the cranial vault (posterior to the bregma) to the center of the external acoustic meatus (Fig. 2.3b). Bordering the sella turcica is a bony thickening at the apex of its anterior wall, the tuberculum sellae, protruding upward as much as 3 mm to terminate into two, small, bony eminences, the middle clinoid process. Lateral and above are the anterior clinoid processes, forming the tip of the lesser wings of the sphenoid. The tuberculum sellae also forms the posterior wall of the chiasmatic groove into which rests the optic chiasm (Fig. 2.3a, c, d). Just above the optic chiasm are the anterior cerebral and anterior communicating arteries of the circle of Willis, the lamina terminalis, and third ventricle of the hypothalamus (Fig. 2.3d).
Lateral to the sella are the cavernous sinuses (Fig. 2.4a–c), a collection of spaces, loculated by fibrous septa between the outer periosteal and inner meningeal dural sheaths. The outer periosteal dural sheath covers the floor and anterior and posterior walls of the sella. The inner meningeal dura forms the lateral wall and roof of the cavernous sinus, gives rise to a very thin medial meningeal lining that serves as its medial wall and adheres to the capsule of the pituitary gland [12], and fuses with the cerebellar tentorium at the roof and superior aspects of the lateral walls of the sella turcica (Fig. 2.4c). Venous blood from the cavernous sinus (Fig. 2.4a) exits via endocranial tributaries of the internal jugular veins that include the superior and inferior petrosal sinuses and exocranial tributaries of the internal jugular vein, including the ophthalmic and facial veins.
Within the space between the medial and lateral walls of the cavernous sinus (Fig. 2.4a), a loose, reticular, connective tissue membrane envelops the oculomotor (III), trochlear (IV), abducens (VI), ophthalmic (V1), and maxillary (V2) branches of the trigeminal nerves and a sympathetic plexus that surrounds the internal carotid artery [12]. The internal carotid artery is separated from the pituitary gland by at least 2 mm but occasionally can indent the pituitary parenchyma. Once in the cavernous sinus, the internal carotid artery courses horizontally and anteriorly for ~2 cm (Fig. 2.4b–d), then forms a genu forward, and is fixed to either the anterior clinoid process by a dural ring (carotid collar) or between the anterior and middle clinoid processes by an osseous ring, the caroticoclinoidal ring.
Posteriorly, the sella turcica is bordered by the dorsum sellae (Fig. 2.3a) and the posterior clinoid processes (Fig. 2.3a). Anterior and caudal to the dorsum sellae, venous lacunae are found between the periosteal linings and the pituitary capsule [13], including the posterior intercavernous sinus and basilar sinus [14]. Connections between the posterior intercavernous sinus and the anterior intercavernous sinus
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Title: How to become a scientist Giving interesting and instructive experiments in chemistry, mechanics, acoustics and pyrotechnics
Author: Aaron A. Warford
Release date: August 30, 2023 [eBook #71522]
Language: English
Original publication: New York: Frank Tousey, 1900
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CONTENTS
How to Become a Scientist. Pneumatic Amusements. Amusements in Mechanics. Arithmetical Amusements.
How to Become a Chemist. Acoustics. Fireworks.
How to Become a Scientist.
GIVING
Interesting and Instructive Experiments IN CHEMISTRY, Mechanics, Acoustics AND PYROTECHNICS.
ALSO CONTAINING MATHEMATICAL PROBLEMS and PUZZLES BOTH USEFUL AND AMUSING.
N Y : FRANK TOUSEY, Publisher, 24 U S
Entered according to Act of Congress, in the year 1900, by
FRANK TOUSEY,
in the Office of the Librarian of Congress at Washington, D. C.
How to Become a Scientist.
Chemistry, optics, pneumatics, mechanics, and mathematics, all contribute their share towards furnishing recreation and sport for the social gathering, or the family fireside. The magical combinations and effects of chemistry have furnished an almost infinite variety of pleasant experiments, which may be performed by our youthful friends with great success if a little care be taken; and the other branches of natural science are nearly as replete with interest.
The following repertoire of such tricks and illusions will be found exceedingly complete, although pains have been taken to select only the best and most startling of them. A large number are entirely new, but are described with sufficient clearness to enable any person of ordinary intelligence to become expert in them, with a little practice.
Chemical Amusements.
Chemistry is one of the most attractive sciences. From the beginning to the end the student is surprised and delighted with the developments of the exact discrimination, as well as the power and capacity, which are displayed in various forms of chemical action. Dissolve two substances in the same fluid, and then, by evaporation or otherwise, cause them to reassume a solid form, and each particle will unite with its own kind, to the entire exclusion of all others. Thus, if sulphate of copper and carbonate of soda are dissolved in boiling water, and then the water is evaporated, each salt will be reformed as before. This phenomenon is the result of one of the first principles of the science, and as such is passed over without thought; but it is a wonderful phenomenon, and made of no account, only by the fact that it is so common and so familiar.
It is by the action of this same principle, “chemical affinity,” that we produce the curious experiments with
Sympathetic Inks.
By means of these, we may carry on a correspondence which is beyond the discovery of all not in the secret. With one class of these inks, the writing becomes visible only when moistened with a particular solution. Thus, if we write to you with a solution of the sulphate of iron, the letters are invisible. On the receipt of our letter, you rub over the sheet a feather or sponge, wet with a solution of nut-galls, and the letters burst forth into sensible being at once, and are permanent.
2. If we write with a solution of sugar of lead, and you moisten with a sponge or pencil, dipped in water impregnated with sulphureted hydrogen, the letters will appear with metallic brilliancy.
3. If we write with a weak solution of sulphate of copper, and you apply ammonia, the letters assume a beautiful blue. When the ammonia evaporates, as it does on exposure to the sun, the writing disappears, but may be revived again as before.
4. If you write with the oil of vitriol very much diluted, so as to prevent its destroying the paper, the manuscript will be invisible except when held to the fire, when the letters will appear black.
5. Write with cobalt dissolved in diluted muriatic acid; the letters will be invisible when cold, but when warmed they will appear a bluish green.
We are almost sure that our secrets thus written will not be brought to the knowledge of a stranger, because he does not know the solution which was used in writing, and, therefore, does not know what to apply to bring out the letters.
To Light a Candle Without Touching the Wick.
Let the candle burn until it has a good long snuff; then blow it out with a sudden puff, a bright wreath of white smoke will curl up from the hot wick. Now, if a flame be applied to this smoke, even at a distance of two or three inches from the candle, the flame will run down the smoke and rekindle the wick in a very fantastic manner. To perform this experiment nicely, there must be no draught or “banging” doors while the mystic spell is rising.
Magic Milk.
Lime-water is quite transparent, and clear as common spring water; but if we breathe or blow into it, the bright liquid becomes opalescent and as white as milk.
The best way to try this simple experiment is to put some powdered quicklime into a wine bottle full of cold water; shake them well together, now and then, for a day; then allow the bottle to remain quiet till the next day, when the clear lime-water may be poured off from the sediment. Now fill a wine-glass or tumbler with the limewater thus made, and blow through the liquid with a glass tube, a piece of new tobacco-pipe, or a clean straw, and in the course of a minute or so—as the magicians say—“the water will be turned into milk.” By means of this pastime “Wise Men” can ascertain which young ladies are in love and which young gentlemen are not. With a shrewd guess they present, as a test, a glass of lime-water to the one and of pure water to the other, with unerring effect.
The Mimic Vesuvius.
This experiment is a demonstration of the heat and light which are evolved during chemical combination. The substance phosphorus has a great affinity for oxygen gas, and wherever it can get it from it will, especially when aided by the application of heat. To perform this experiment, put half a drachm of solid phosphorus into a Florence oil-flask, holding the glass slantingly, that the phosphorus may not take fire and break the glass; pour upon it a gill and a half of water, and place the whole over a tea-kettle lamp, or any common lamp filled with spirits of wine; light the wick, which should be about half an inch from the flask; and as soon as the water is boiling hot, streams of fire, resembling sky-rockets, will burst at intervals from the water; some particles will also adhere to the sides of the glass, immediately displaying brilliant rays, and thus continue until the water begins to simmer, when a beautiful imitation of the aurora borealis will commence and gradually ascend until it collects into a pointed cone at the mouth of the flask; after a half a minute, blow out the flame of the lamp, and the apex of fire that was formed at the mouth of the
flask will rush down, forming beautiful illumined clouds of fire, rolling over each other for some time; and when these disappear, a splendid hemisphere of stars will present itself. After waiting a minute or two, light the lamp again, and nearly the same phenomena will be displayed as at the beginning. Let a repetition of lighting and blowing out the lamp be made for three or four times, so that the number of stars may be increased; and after the third or fourth act of blowing out the lamp, the internal surface of the flask will be dry. Many of the stars will shoot with great splendor from side to side, while others will appear and burst at the mouth of the flask. What liquid remains in the flask will serve for the same experiment three or four times, without adding any water. Care should be taken, after the operation is over, to put the flask in a cool and secure place.
The Real Will-o’-the-Wisp.
Into a small retort place about an ounce of strong liquor of potash; that is, pure potash dissolved in water, together with about a drachm of phosphorus. Let the neck or beak of the retort dip into a saucer of water, say half an inch deep; now very gently heat the liquid in the retort with a spirit-lamp until it boils. In a few minutes the retort will be filled with a white cloud; then the gas generated will begin to bubble at the end of the saucer; a minute more, each bubble, as it issues from the boiling fluid, will spontaneously take fire as it comes into the air, forming at the same time the philosopher’s ring of phosphoric acid. Care is required in handling phosphorus; but our young chemical readers will, we think, not forego this wonderful experiment for the want of due attention; for, without proper care on their part, we must give up showing them wonders even greater than these.
The Paper Oracle.
Some amusement may be obtained among young people by writing, with common ink, a variety of questions, on different bits of paper, and adding a pertinent reply to each, written with nitro-muriate of gold. The collection should be suffered to dry, and put aside, until an opportunity offers for using them. When produced, the answers will
be invisible; desire different persons to select such questions as they may fancy, and take them home with them; then promise, if they are placed near the fire during the night, answers will appear written beneath the questions in the morning; and such will be the fact, if the paper be put in any dry, warm situation.
The Mimic Gas-House.
This shows a simple way of making illuminating gas, by means of a tobacco-pipe. Bituminous coal contains a number of chemical compounds, nearly all of which can, by distillation, be converted into an illuminating gas; as with this gas nearly all our cities are now lighted in the dark hours of night. To make it, obtain some coal-dust (or walnut or butternut meats will answer), and fill the bowl of a pipe with it; then cement the top over with some clay; place the bowl in the fire, and soon smoke will be seen issuing from the end of the stem; when that has ceased coming apply a light and it will burn brilliantly for several minutes; after it has ceased, take the pipe from the fire and let it cool, then remove the clay, and a piece of coke will be found inside: this is the excess of carbon over the hydrogen contained in the coal, for all the hydrogen will combine with carbon at a high temperature, and make what are called hydrocarbons—a series of substances containing both these elemental forms of matter.
Alum Basket.
Make a small basket, about the size of the hand, of iron wire or split willow; then take some lamp-cotton, untwist it, and wind it around every portion of the basket. Then mix alum, in the proportion of one pound with a quart of water, and boil it until the alum is dissolved. Pour the solution into a deep pan, and in the liquor suspend the basket, so that no part of it touch the vessel or be exposed to the air. Let the whole remain perfectly at rest for twenty-four hours; when, if you take out the basket, the alum will be found prettily crystallized over all the limbs of the cottoned frame.
In like manner, a cinder, a piece of coke, the sprig of a plant, or any other object, suspended in the solution by a thread, will become covered with beautiful crystals.
If powdered tumeric be added to the hot solution, the crystals will be of a bright yellow; if litmus be used instead, they will be of a bright red; logwood will yield them of a purple, and common writing-ink, of a black tint; or, if sulphate of copper be used instead of alum, the crystals will be of fine blue.
But the colored alum crystals are much more brittle than those of pure alum, and the colors fly; the best way of preserving them is to place them under a glass shade, with a saucer containing water. This keeps the atmosphere constantly saturated with moisture, the crystals never become too dry, and their texture and color undergo but little change.
The Magic Bottle.
This trick, if well managed, is one of the most wonderful that can be performed in a drawing-room without apparatus; but it requires dexterity at the conclusion.
The person performing the trick offers to pour from a common winebottle, port-wine, sherry, milk, and champagne, in succession, and in any order.
To accomplish the trick, you must make solutions of the following chemicals, and label the bottles with numbers, thus:
No. 1. A mixture of two parts perchloride of iron, and one part sulphuric acid (vitriol).
No. 2. A strong solution of the sulphocyanate of potash.
No. 3. A strong solution of acetate of lead.
No. 4. A solution of bicarbonate of soda, or potash.
No. 5. A clear solution of gum arabic.
Procure a champagne-bottle, and wash it out well; then pour three teaspoonfuls of No. 1 into it. As the quantity is very small, it will not
be observed, especially if you are quick in your movements. Pour some distilled or rain water into a common water-bottle, or jug, and add a tablespoonful of No. 5 to it; then set it aside, ready for use.
Provide some wine-glasses, of four different patterns, and into one pattern put one drop of solution No. 2; into another, three drops of solution No. 2; rinse the third with solution No. 3, and the fourth with solution No. 4.
Arrange the glasses on a small tray, remembering the solutions that were poured into each pattern.
Everything being ready, take the champagne bottle that you have prepared, from two or three others, and holding it up, to show the company that it is clear and empty; you must desire some person to hand you the water-bottle or jug, and then fill up the bottle with the water.
Pour some of the contents of the bottle into an unprepared glass, in order to show that it is water; then say: “Change to champagne,” and pour the liquid from the bottle into one of the glasses rinsed with No. 4; then pour into the glass containing three drops of No. 2, and it will change to port wine; but if poured into the glass rinsed with No. 3, it will change to milk; and if into the glass with one drop of No. 2, it will produce sherry.
Be careful in pouring the fluid from the bottle, not to hold it high above the glasses, but to keep the mouth of it close to the edges, otherwise persons will observe that it undergoes change of color after it is poured into them; and, on this account, the glasses should be held rather high.
As all the solutions used in the above trick are deleterious, they should not be left about in the way of children, and, of course, the fluid in the wine-glasses must not even be tasted; but if any of the company wish to drink the wines you have made, then the tray must be adroitly exchanged for another with the proper wines placed on it.
The Faded Rose Restored.
Take a rose that is quite faded, and throw some sulphur on a chafing-dish of hot coals; then hold the rose over the fumes of the sulphur, and it will become quite white; in this state dip it into water, put it into a box, or drawer, for three or four hours, and when taken out it will be quite red again.
The Protean Liquid.
A red liquor, which, when poured into different glasses, will become yellow, blue, black, and violet, may be thus made: Infuse a few shavings of logwood in common water, and when the liquor is red, pour it into a bottle; then take three drinking-glasses, rinse one of them with strong vinegar, throw into the second a small quantity of pounded alum, which will not be observed if the glass has been newly washed, and leave the third without any preparation. If the red liquor in the bottle be poured into the first glass it will assume a straw color; if into the second, it will pass gradually from bluish-gray to black, provided it be stirred with a bit of iron, which has been privately immersed in good vinegar; in the third glass the red liquor will assume a violet tint.
The Changeable Ribbon.
Dip a rose-colored ribbon into nitric acid, diluted with eight or ten parts of water, and as soon as the color disappears, which it will do in a short time, take out the ribbon and put it into a very weak alkaline solution, when the alkali will quickly neutralize the acid, and the color will reappear.
The Chemical Chameleon.
Put a drachm of powdered nitrate of cobalt into a vial, containing an ounce of the solution of caustic potash, when the decomposition of the salt, and precipitation of a blue oxide of cobalt will take place. Cork the vial, and the liquid will assume a blue color, from which it will pass to a lilac, afterward to a peach tint, and finally to a light red.
Musical Flame.
Fit a good cork into a wine-bottle; burn a hole through the cork with a round iron skewer, and into it fix a piece of tobacco pipe about eight inches long. Put into the bottle about two or three ounces of zinc, in slips, such as the waste cuttings from a zinc-worker; now pour water on to the zinc until the bottle is more than half full; then add about three parts of a wine-glassful of sulphuric acid (oil of vitriol); this causes a rapid effervescence at first, but which subsides to a moderate and continuous boiling for a lengthened period; as soon as the boiling is regular, the cork with the pipe through it may be inserted into the bottle. If a light be placed to the end of the pipe, a flame will be produced, which will continue to burn so long as there is any visible action in the bottle. This flame is the ignited hydrogen gas (water gas), resulting from the decomposition of water by the acid and zinc, and as such is an exceedingly interesting experiment. Now, to be musical, procure a glass or metal pipe, about sixteen or eighteen inches long, and from half to three-quarters of an inch in diameter; place the tube over the flame, and allow the pipe to be about three to five inches up the tube, which will act as a kind of high chimney; it must be held perfectly steady and upright, at a particular distance up the tube, which varies according to the size of the flame. A beautiful sound is thus produced, similar to an organ-pipe. This sound, or “musical flame,” varies in note according to the diameter of the tube, being deeper or more bass as the tube is increased in size. By using various-sized tubes, different sounds are thus readily produced. The true explanation of this singular experiment remains yet to be solved.
Optical Amusements.
The science of optics affords an infinite variety of amusements, which cannot fail to instruct the mind, as well as delight the eye. By the aid of optical instruments we are enabled to lessen the distance to our visual organs between the globe we inhabit and “the wonders of the heavens above us;” to watch “the stars in their courses,” and survey at leisure the magnificence of “comets importing change of
times and states;” to observe the exquisite finish and propriety of construction which are to be found in the most minute productions of the earth;—to trace the path of the planet, in its course around the magnificent orb of day, and to detect the pulsation of the blood, as it flows through the veins of an insect. These are but a few of the powers which this science offers to man; to enumerate them all would require a space equal to the body of our work; neither do we propose to notice the various instruments and experiments which are devoted to purposes merely scientific; it being our desire only to call the attention of our juvenile readers to such things as combine a vast deal of amusement with much instruction, to inform them as to the construction of the various popular instruments; to show the manner of using them, and to explain some of the most attractive experiments which the science affords. By doing thus much, we hope to offer a sufficient inducement to extend inquiry much further than the information which a work of this nature will enable us to afford.
The Camera Obscura.
This is a very pleasing and instructive optical apparatus, and may be purchased for a small sum. But it may be easily made by the young optician. Procure an oblong box, about two feet long, twelve inches wide, and eight high. In one end of this a tube must be fitted containing a lens, and be made to slide backward and forward, so as to suit the focus. Within the box should be a plain mirror, reclining backward from the tube at an angle of forty-five degrees. At the top of the box is a square of unpolished glass, upon which, from beneath, the picture will be thrown, and may be seen by raising the lid. To use the camera, place the tube with the lens on it opposite to the object, and having adjusted the focus, the image will be thrown upon the ground glass, as above stated, where it may be easily copied by a pencil or in colors.
The Magic Lantern.
The object of this ingenious instrument is to represent, in a dark room, on a white wall or cloth, a succession of enlarged figures of remarkable, natural, or grotesque objects. It consists of a tin box, with a funnel on the top, and a door on one side of it. This funnel, by being bent, serves the double purpose of letting out the smoke and keeping in the light. In the middle of the bottom of the box is placed a movable lamp, which must have two or three good lights, at the height of the center of the polished tin reflector. In the front of the box, opposite the reflector, is fixed a tin tube, in which there slides another tube. The sliding tube has, at its outer extremity, a convex lens fixed in it, of three inches in diameter. The focus of the smaller of these lenses may be about five inches. Between the stationary tube and the lamp, there must be a split or opening to admit of the passage of glass sliders, mounted in paper or wooden frames, upon which sliders it is that the miniature figures are painted, which are intended to be shown upon the wall. The distinctness of the enlarged figures depends not only upon the goodness of the magnifying glass, but upon the clearness of the light yielded by the lamp. It may be purchased ready made of any optician.
To Paint the Glasses.—The slides containing the objects usually shown in a magic lantern are to be bought of opticians with the lantern, and can be procured cheaper and better in this way than by any attempt at manufacturing them. Should, however, the young optician wish to make a few slides, of objects of particular interest to himself, he may proceed as follows: Draw on a paper the subject you desire to paint. Lay it on a table or any flat surface, and place the glass over it; then draw the outlines with a very fine pencil, in varnish mixed with black paint, and, when dry, fill up the other parts in their proper colors. Transparent colors must be used for this purpose, such as carmine, lake, Prussian blue, verdigris, sulphate of iron, tincture of Brazil wood, gamboge, etc.; and these must be tempered with a strong white varnish, to prevent their peeling off. Then shade them with black, or with bistre, mixed with the same varnish.
To Exhibit the Magic Lantern.—The room for the exhibition ought to be large, and of an oblong shape. At one end of it suspend a large sheet, so as to cover the whole of the wall. The company being all
seated, darken the room, and placing the lantern with its tube in the direction of the sheet, introduce one of the slides into the slit, taking care to invert the figures; then adjust the focus of the glasses in the tube, by drawing it in or out, as required, and a perfect representation of the object will appear.
Effects of the Magic Lantern.—Most extraordinary effects may be produced by means of the magic lantern; one of the most effective of which is a tempest at sea.
This is effected by having two slides painted, one with the tempest as approaching on one side, and continuing in intensity till it reaches the other. Another slide has ships painted on it, and while the lantern is in use, that containing the ships is dexterously drawn before the other, and represents ships in the storm.
The effects of sunrise, moonlight, starlight, etc., may be imitated also, by means of double sliders; and figures may be introduced sometimes of fearful proportions.
Heads may be made to nod, faces to laugh; eyes may be made to roll, teeth to gnash; crocodiles may be made to swallow tigers; combats may be represented; but one of the most instructive uses of the slides is to make them illustrative of astronomy, and to show the ratio of the seasons, the cause of the eclipses, the mountains in the moon, spots on the sun, and the various motions of the planetary bodies and their satellites.
The Phantasmagoria.
Between the phantasmagoria and the magic lantern there is this difference: in common magic lanterns the figures are painted on transparent glass; consequently the image on the screen is a circle of light, having figures upon it; but in the phantasmagoria all the glass is opaque, except the figures, which, being painted in transparent colors, the light shines through them, and no light can come upon the screen except that which passes through the figure.
There is no sheet to receive the picture, but the representation is thrown on a thin screen of silk or muslin, placed between the
