Menzies 2019 Highlights

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Menzies Institute for Medical Research 2019 HIGHLIGHTS


TA B L E O F CO N T E N T S

4

Grants and Fellowships

6

Financial Report

Staffing Profile

7

8

Research Themes

10

Excellence Awards

Multiple Sclerosis Research Flagship

12

Major Grants and Competitive Funding

16

Philanthropy Community Engagement Media Mentions

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17

Board Members


Menzies exists to perform internationally significant medical research leading to healthier, longer and better lives for Tasmanians.

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GRANTS AND FELLOWSHIPS

286

Number of Grants

Grant Value

41

$24,886,576

Major Grants - 21

Major Grants - $24,381,190

Minor Grants - 20

Minor Grants - $505,386

T H E N U M B E R O F P E E R R E V I E W E D R E S E A R C H P U B L I C AT I O N S

( A 1 R E F E R E E D A R T I C L E I N A S C H O L A R LY J O U R N A L ) F R O M M E N Z I E S I N 2 0 1 9

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S TA F F A N D S T U D E N T P R O F I L E

99

75 57 Higher Degree Research Students  Masters

PHD

Honours Students   Academic Staff 18   Professional Staff

3

Casual staff On average, each week we had casual staff working the equivalent of 8.36FTE through 2019. Casual staff reported as total FTE to avoid double counting due to the high number of casual staff having other roles within our organisation.

Staff by gender

7

50

Academic Staff

Professional Staff   Male staff

27

Female staff

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48


FINANCIAL REPORT 1 January to 31 December 2019

2018 Actual

2019 Actual

Commonwealth Government Research Support

$  5,015,212

$  4,835,322

Teaching Income

$  617,467

$  611,288

Commonwealth Government Research Grants

$  3,856,354

$  4,775,131

Tasmanian Government grants

$  1,762,148

$  1,537,763

Other Contracts and Agreements

$  4,847,207

$  4,520,703

Donations

$  2,088,616

$  1,862,898

Bequests

$  1,540,392

$  2,827,679

Investment Income

$  34,298

$  3,420,353

Sales

$  358,294

$  381,597

Other Income

$  452,694

$  384,859

UTAS Contributions

$  123,616

$  160,743

$  20,696,299

$  25,318,337

Salaries and On-Costs

$

13,721,410

$

13,683,395

Depreciation, Equipment and Infrastructure

$

861,285

$

1,037,193

Medical and Laboratory Materials

$

1,411,082

$

2,192,799

Travel and Training Related Costs

$

742,048

$

601,890

Scholarships

$

1,028,037

$

1,221,727

Research Sub-Contractors and Consultants

$

734,841

$

1,024,920

Other Expenses

$

804,964

$

802,928

$

19,303,667

$

20,564,853

$

1,392,631

$

4,753,485

Income

Expenses

Surplus/(Deficit) before University Central Over-heads

As at 31 December 2019, Menzies held Trust Funds valued at $26,367,594. The capital amount of this trust was valued at $17,844,679. Investment return distributions provide a source of research income for Menzies. The non-capital component of these trust funds is available for use in accordance with the benefactors’ instructions. The University of Tasmania’s Advancement Office manages a number of trusts on behalf of Menzies. As at 31 December 2019, the value of these trusts was $1,007,007. Distributions are made by agreement between the Advancement Office and Menzies in accordance with the benefactors’ instructions.

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RESEARCH THEMES

Public Health, Primary Care and Health Services We work to better prevent and manage important health problems that impact large sections of our population. We focus on multiple sclerosis, obesity, environmental and mental health.

Brain Health and Disease Our research focuses on brain diseases that affect many Australians, including multiple sclerosis and motor neurone disease. We work to help guard the nervous system against movement and memory disorders.

Cardiovascular and Respiratory Health and Disease We aim to improve the prevention and management of cardiovascular and respiratory disease in the community. We focus on the risk factors that contribute to heart attacks, stroke, and lung disease.

Musculoskeletal Health and Disease Our musculoskeletal research focuses on osteoarthritis and osteoporosis. We work to make a difference to people with musculoskeletal disease, including by testing treatments in clinical trials.

Genetics and Cancer We aim to understand how genes contribute to disease with a focus on cancer and eye disease. Our research seeks to diagnose, prevent and treat diseases using personalized, precision medicine based on genetics.

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M U LT I P L E S C L E R O S I S R E S E A R C H F L A G S H I P The Menzies MS Research Flagship was established in 2016, bringing together our significant research capacity and leaders in the field. Tasmania has the highest prevalence of people living with MS in Australia and the aim was to increase the scope and impact of MS research. Five research themes make up the MS Research Flagship, including Brain Health, Genomics, Clinical Trials, Epidemiology and Health Economics, employing over twenty researchers and professional staff, as well as a number of PhD students. The breadth of MS research conducted in 2019 includes 21 projects across the five theme areas from a variety of funding sources, totalling over $17.6 mil in competitive award funding.

MS Projects by Research Theme

1

1

Includes externally led

6

Brain health Clinical Trials

6

Geonomics Epidemiology Health Economics

5

2

1

Cross Disciplinary

MS Projects by Funder

1

Excludes externally led

Multiple Sclerosis Research Australia

6

MS Limited Royal Hobart Hospital Research Foundation (RHHRF)

4

National Health and Medical Research Council (NHMRC) Medical Research Future Fund (MRFF)

2

1

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IOOF Foundation


MEDICAL RESEARCH FUTURE FUND $10 MILLION FUNDING

E M E R G I N G P R I O R I T I E S CO N S U M E R - D R I V E N R E S E A R C H I N I T I AT I V E

Funded over 4.5 Years this funding will expand the scope of the MS Research Flagship and accelerate discoveries in MS Research by supporting five key activities; 1. Establish ‘MS Stem’ – a stem cell bank specifically designed to advance MS research 2. Gain a better understanding of the regeneration of brain cells and myelin repair 3. Expand our understanding of the rare genetic variation underpinning MS using genome sequencing of MS families and ‘MS Stem’ cell bank samples

awareness of MS. Members of the public increase their knowledge of MS-related issues and those in the MS community will be empowered to create and contribute to personalised MS management plans. The course is a partnership with MS Limited and the Wicking Dementia Research and Education Centre and uses a multimedia approach with experts and people living with MS sharing their knowledge and insights; • To date, more than 7,600 people from 128 countries have enrolled in the course • Approximately 80% are female and about 50% are people living with MS or friends and family of people living with MS

4. Develop a treatment economic model that can identify cost-effective treatments and interventions for MS

• The Understanding MS free online course was rated first among over 2,400 MOOCs (massive open online courses) offered in 2019 worldwide

5. Develop education tools and online resources, including an App specifically for people living with MS This work leverages the unique critical mass of MS research in Tasmania connected with Australian MS researchers, collaborators, MS societies and people with MS to address the gaps in the assessment, diagnosis and treatment of MS.

Our work to date shows that 97% of course completers are satisfied with the course overall and 98% rate the quality of the course as above average. Further, 63% of course completers report that they have applied information from the course by the time they completed it.

Understanding MS Free Online Course: Understanding MS is a free online course for people all around the world to improve understanding and

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MENZIES EXCELLENCE AWARDS 2019

BEST OF THE BEST

P O P U L AT I O N H E A LT H

For outstanding research achievement, evidenced through publication in a scholarly journal.

Hoang Phan ‘Sex Differences in Long-Term Health-Related Quality of Life Among Survivors After Stroke: The INternational STroke OutComes Study (INSTRUCT).’ Published in Stroke.

Dr Amanda Patchett ‘Two of a Kind: Transmissible Schwann Cell Cancers in the Endangered Tasmanian Devil (Sarcophilus Harrisii)’ - published in Cellular and Molecular Life Sciences. Amanda’s paper demonstrates that the two known Devil facial tumours, DFT1 and DFT2, have originated from a similar cell type and that the mechanisms of tumorigenesis are likely to be different between the two. Both of these pieces of information are important for understanding the susceptibility of devils to transmissible tumours and in developing strategies to mitigate the risk and progression of the disease in this endangered species. Historically, most of the genetics and genomics work relating to Tasmanian Devils and the DFT disease has been led by research groups overseas and interstate. The skills demonstrated in executing this research to such a high standard are a notable achievement.

L A B O R ATO RY R E S E A R C H Carlie Cullen ‘Low-Intensity Transcranial Magnetic Stimulation Promotes the Survival and Maturation of Newborn Oligodendrocytes in the Adult Mouse Brain.’ Published in Glia. Kimberley Pitman and Raphael Ricci ‘The Voltage-Gated Calcium Channel CaV1.2 Promotes Adult Oligodendrocyte Progenitor Cell Survival in the Mouse Corpus Callosum but Not Motor Cortex.’ Published in Glia.

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Jingyi Shao ‘Early Life Exposure to Coal Mine Fire Smoke Emissions and Altered Lung Function in Young Children.’ Published in Respirology. Julie Campbell ‘Change in Multiple Sclerosis Prevalence Over Time in Australia 2010-2017 Utilising Disease Modifying Therapy Prescription Data.’ Published Multiple Sclerosis Journal. Johanna Wilson ‘An Eating Pattern Characterised by Skipped or Delayed Breakfast is Associated with Mood Disorders Among an Australian Adult Cohort.’ Published in Psychological Medicine.

CLINICAL RESEARCH Bennet McComish ‘Association of Genetic Variation with Keratoconus’. Published in JAMA Ophthalmology. Matthew Armstrong ‘Brachial and Radial Systolic Blood Pressure Are Not the Same’. Published in Hypertension. Feng Pan ‘Pain at Multiple Sites Is Associated With Prevalent and Incident Fractures in Older Adults’. Published in Journal of Bone and Mineral Research.


MENZIES EXCELLENCE AWARDS 2019

R ESE A RCH I M PAC T PR IZE To recognise research that has had demonstrable benefits to society. Professor Peter Dargaville for GREMLINS (Group of Engineers and Medics Laboriously Investigating Neonatal Systems). In collaboration with partners in engineering and industry, Professor Peter Dargaville and his team developed new technology that has improved breathing in babies in neonatal intensive care.

AC ADEMIC MENTORING AWA R D Professor Tracey Dickson For recognition of the significant and ongoing contributions made to the career and professional development of staff and students.

P R O F E S S I O N A L S TA F F AWA R D For outstanding achievement through exceptional performance and contributions to the Institute. Emerson Easley Administrative Assistant, Environmental Health Team and the Childhood Determinants of Adult Health Study Team.

AWA R DS A N D R ECOGN ITION Dr Carlie Cullen 2019 Tasmanian Young STEM Researcher Award Professor Graeme Jones and Lachlan Tegart Fulbright Future Scholarship Associate Professor Fay Johnston Clean Air Society of Australia and New Zealand “2019 Air Quality Champion Award” Niamh Chapman and Matt Armstrong 2019 Tasmanian ASMR Medical Research Week Student Awards

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MAJOR GRANTS AND COMPETITIVE FUNDING In 2019, we were awarded the following nationally competitive grants and fellowships.

Funding body

Grant category

Menzies researchers

Project title

Value $

MAJOR COMPE TITIVE GR ANTS

MRFF

Accelerated Research

Professor Bruce Taylor, Associate Professor Kaylene Young, Dr Jac Charlesworth, Assoc Professor Ingrid van der Mei, Professor Andrew Palmer

NHMRC

Synergy

Associate Professor Seana Gall, Professor Mark Nelson

Synergies TO Prevent stroke STOPstroke

5,000,000

NHMRC

Investigator Grant

Dr Costan Magnussen

The Long-Term Effects of Child, Adolescent, and Young Adult Cholesterol Levels on Future Cardiovascular Disease

1,449,339

NHMRC

Ideas

Professor Kathryn Burdon, Dr Bennet McComish

Identifying the Genetic Causes and Modifiers of Paediatric Cataract

1,011,130

NHMRC

Partnership Project

Professor James Sharman, Distinguished Professor Alison Venn, Professor Mark Nelson

Improved Cardiovascular Disease Health Service Delivery in Australia (IDEAL Study)

1,003,230

NHMRC

Ideas

Professor Peter Dargaville

Prediction and Detection of Apnoea in Preterm Infants

823,982

MRFF

Accelerated Research

Professor Alex Hewitt

Pre-clinical validation, optimisation, and safety profiling of CRISPR/Casbase editing for PCDH15-related disease.

733,314

683,290

The Menzies Multiple Sclerosis Flagship Program

10,000,000

NHMRC

Ideas

Dr Guei-Sheung Liu

Losing the Needle: Using Eye DropBased Switchable Gene Therapy as a Non-Invasive Controlled Intervention in Neovascular Blindness

NHMRC

Investigator Grant

Dr Yuan Zhou

Elucidating The Genetic Architecture Of Multiple Sclerosis To Influence Improvements In Disease Outcomes

562,013

ARC

Discovery Projects

Professor Tracey Dickson

Microfluidic Models of the CNS: Understanding Cells, Circuits & Synapses

545,563

NHMRC

Ideas

Dr Owen Marshall

There and Back Again: Understanding the Epigenetic Remodelling That Turns Gila Into Glioma

536,847

Grant

Fellowship

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MAJOR GRANTS AND COMPETITIVE FUNDING CONTINUED

Funding body

Grant category

Menzies researchers

Project title

Value $

MAJOR COMPE TITIVE GR ANTS CONTINUED Heart Foundation Australia

Future Leader Fellowship

Dr Martin Schultz

Exercise Physiology to Improve the Detection of High Blood Pressure

535,120

Australian Coal Association Research Program

Grant

Professor Graeme Zosky

The Physicochemical Properties of Coal Dust and the Risk of Black Lung

411,600

210,000

Multiple Sclerosis Research Australia

Postdoctoral

Dr Julie Campbell

Economic Impact of MS: Creating Independent Standards for Health Economic Evaluation of MS Interventions Aimed to Prevent MS or Halt Disease Severity

Multiple Sclerosis Research Australia

Postdoctoral

Dr Kalina Makowiecki

How Does Myelin Plasticity Impact Neural Circuit Function in Multiple Sclerosis?

210,000

MRFF

Targeted Health System and Community

Dr Barbara de Graaff, Dr Julie Campbell, Dr Karen Wills, Professor Andrew Palmer

ANCHOR Project: Health Economics and Epidemiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

155,000

153,850

National Heart Foundation

Postdoctoral

Dr Jing Tian

Understanding the Determinants and Cardiometabolic Consequences of Divergent Adiposity Trajectories from Childhood to Midlife: the InternationalChildhood Cardiovascular Cohort (i3C) Consortium

Maddie Riewoldt's Vision

Alex Gadomski

Dr Kirsten Fairfax, Professor Alex Hewitt

Functional Interrogation of Loci Associated with the Regulation of Haematopoiesis

149,512

MRFF

Keeping Australians Out of Hospital

Professor Thomas Marwick, Professor James Sharman, Kristyn Whitmore

Risk-guided Strategy for ReducingReadmission for Acute Decompensated Heart Failure (RiskHELP)

107,400

Rebecca L Cooper Medical Research Foundation

Grant

Dr Benny Eathakkattu

A Randomised Comparative Effectiveness Clinical Trial of Yoga for Knee Osteoarthritis

100,000

Grant

Fellowship

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MAJOR GRANTS AND COMPETITIVE FUNDING CONTINUED

Funding body

Grant category

Menzies researchers

Project title

Value $

MINOR GRANTS NHMRC

Postgraduate

Professor Peter Dargaville, Dr Kathleen Lim

Detection, Prediction and Mitigation of Apnoea in Preterm Infants

90,793

Ophthalmic Research Institute of Australia

Research

Professor Alex Hewitt

Engineering a Synthetic Microbial Treatment for Gyrate Atrophy

50,000

Lung Foundation Australia

PhD

Professor Andrew Palmer, Dr Barbara de Graaff, Ingrid Cox

The Epidemiology and Health Economics of Idiopathic Pulmonary Fibrosis

45,000

Arthritis Australia

Project

Dr Feng Pan, Professor Graeme Jones

The Role of Systemic Inflammation In Osteoarthritis Pain Trajectories

44,000

Arthritis Australia

ARA

Dr Saliu Balogun

A Randomised Controlled Trial Evaluating Community Walking for Knee Osteoarthritis

30,000

Royal Hobart Hospital Research Foundation

Project

Dr Barbara de Graaff, Dr Julie Campbell, Professor Andrew Palmer, Dr Stella Lartey

NAFLD-Screen (Non-Alcoholic Fatty Liver disease: Prevalence and Screening for Type 2 Diabetes Patients)

24,999

Royal Hobart Hospital Research Foundation

Project

Professor Jo Dickinson, Dr Guei-Sheung Liu, Dr Liesel Fitzgerald, Professor Alex Hewitt

Gaining New Insights Into Metastatic Bone Tumours

24,925

Royal Hobart Hospital Research Foundation

Project

Dr Bennet McComish, Professor Kathryn Burdon

Understanding Individual Differences in Response to Treatment for Diabetic Eye Disease

24,888

University of Tasmania

Research Enhancement Program

Dr Saliu Balogun, Associate Professor Dawn Aitken, Professor Tania Winzenberg, Dr Laura Laslett

Assessing the Australian Osteoarthritis Landscape - GPs’ Surgeons’ and Patients Attitudes Towards and Understandings of Osteoarthritis

24,824

Royal Hobart Hospital Research Foundation

Project

Dr Liesel Fitzgerald, Professor Jo Dickinson

A Clinical and Biospecimens Prostate Cancer Resource for Biomarker Research in Tasmania

22,664

University of Tasmania

Research Enhancement Program

Dr Penny Jones, Associate Professor Fay Johnston, Professor Jo Dickinson

Human health and the Aerial Microbiome: Uncovering Interactions Across Australia

19,989

University of Tasmania

Research Enhancement Program

Professor Graeme Zosky

In Utero Exposure to Bushfire Smoke and Post-Natal Health

17,171

Grant

Fellowship

Scholarship

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MAJOR GRANTS AND COMPETITIVE FUNDING CONTINUED

Funding body

Grant category

Menzies researchers

Project title

Value $

MINOR GRANTS Royal Hobart Hospital Research Foundation

Project

Dr Carlie Cullen, Associate Professor Kaylene Young, Professor Bruce Taylor

Clinical Safety Assessment of rTMS Application for the Treatment of MS

16,000

University of Tasmania

Research Enhancement Program

Dr Amanda Patchett, Dr Andy Flies

Identification of Host-Tumour Interactions Driving Immune Evasionand Survival of Devil Facial Tumor Disease

12,951

Motor Neurone Disease Research Institute of Australia Inc

PhD Top-Up Grant

Dr Cathy Blizzard

Neuronal Excitability in ALS a Focus on TDP43 mislocalisation

11,250

Royal Hobart Hospital Research Foundation

Incubator

Associate Professor Fay Johnston, Dr Barbara de Graaff, Professor Andrew Palmer

Association Between Bush Firesmoke/Wood-Smoke and Hospital Usage in Tasmania

10,000

Centre for Air Quality and Health Research Evaluation

Project

Associate Professor Fay Johnston, Dr Penny Jones

Port Macquarie Rapid Response

10,000

University of Tasmania

Research Enhancement Program

Associate Professor Fay Johnston, Professor Andrew Palmer, Dr Penny Jones, Professor Graeme Zosky

What is the Economic Impact of Allergic Respiratory Disease in Tasmania?

10,000

University of Tasmania

Research Enhancement Program

Dr Andrew Flies, Dr Amanda Patchett, Dr Ruth Pye, Dr Guei-Sheung Liu

Development of a Devil Facial Tumour Bait-Vaccine for Landscape-Level Distribution

9,952

Cass Foundation (Contributing to Australian Scholarship and Science)

Travel

Dr Benny Eathakkattu

CASS Foundation Travel Grant

4,480

Motor Neurone Disease Research Institute of Australia Inc

Jenny and Graham Lang Collaboration Travel

Dr Katherine Lewis

Targeting ALS Cortical Excitability Dysfunction Through Nasal Delivery of Neuropeptide Y

1,500

Grant

Fellowship

Scholarship

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PHILANTHROPY We gratefully acknowledge all the individuals and organisations who donated to us in 2019. Thanks to these philanthropic activities and our meaningful community connections and events we can continue to conduct and share internationally significant medical research that leads to healthier, longer and better lives for Tasmanians.

4.87 M IL L IO N

2 .8 MI LLI O N

12 E STATE S

2,660 P EOP LE

148 P EOP LE

TOTAL PHILANTHROPIC INCOME

INCOME FROM BEQUESTS

PLANNED GIFTS

INDIVIDUAL DONATIONS

EVERYDAY ANGELS

In 2019, the generosity of our donors supported eight researchers on full fellowships and four on partial fellowships as well as five honours students and eleven PhD students in their endeavours.

COMMUNITY ENGAGEMENT Community engagement (numbers engaged)

Number of community events

55

2

660

6

14

1,649 6,065

Community event

Community talk

43

Community tour

MEDIA MENTIONS = 1007 National and International Print, Television, Radio and Online Media.

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Menzies event


BOARD Mr Bruce Neill (Chair) Distinguished Professor Alison Venn (Director)

Professor Moira Clay

Ms Philippa Leedham

Professor Denise Fassett

Professor Stephen Tong

Professor Anthony Koutoulis

Professor Bob Williamson