Augusta Medical Examiner

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JUNE 1, 2012

H T E F Y O E N AR A M Two Thousand Twelve

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Aspirin bottle, 1900

ore than twenty years ago, then-editor of Augusta Magazine, Beth Siciliano, gave me an assignment to write an article about once-a-day aspirin therapy. At the time, I thought taking aspirin was supposed to be a reactive event, something you did when you had a headache, a toothache, fever. The concept of taking an aspirin on general principles was new to me back then, but it seemed like a fitting commentary on modern life: something is bound to hurt before this day is over, so you might as well accept that fact and just take the aspirin as soon as you get up. It’s going to happen soon enough, so get it over with. I remember jokingly asking Beth, “Is this daily aspirin in addition to the ten or more most of us are already taking in the course of a typical day?” Well, as we all know by now, an aspirin a day has replaced an apple a day as the cornerstone of preventive medicine. Aspirin is at the same time the most mundane of drugs and the most amazing. Quick: name a drug you take if you have a headache — or a stroke. Name an inexpensive, overthe-counter drug that can help prevent heart attacks, blood clots, strokes, cancer — and pain and swelling

from stubbing your toe. The answer for all these situations and more is aspirin, a modern-day miracle drug if ever there was one. New benefits from aspirin continue to be discovered. But an aspirin a day isn’t for everyone. Who should take pains to avoid aspirin? How did this amazing drug come to be, and how does it work? A drug with an ancient history Most histories of aspirin begin with Hippocrates in the fifth century B.C. writing about a bitter powder made from willow bark that helped ease aches and pains and reduce fevers. Actually, aspirin’s origins date much farther back, into earliest Biblical times: remember God telling Moses, “take these two tablets”? Fast forward many centuries to the late 1890s and we meet Felix Hoffman, the German chemist pictured above (and that’s aspirin’s molecular structure on the left), an employee of a company you may have heard of: Bayer. For several decades prior to his appearance in the story, salicin or salicylic acid had been given in high doses to treat pain, Please see ASPIRIN page 2

THE SKINNY ON BAYER’S WAR HEADACHES Aspirin emerged from the labs of Bayer, a German company, in 1899. Business was good and growing until Germany went to war in 1914. German assets in Britain were frozen, and Allied nations like the US were not inclined to buy products from enemy nations. This had a negative effect on the aspirin supply at a time when it was desperately needed. Beginning in 1915, Bayer set up a number of shell corporations and subsidiaries in the US to guard against the possibility that, if America entered the war, Bayer’s sales and assets in the US would be lost. A US war office called the Alien Property Custodian was established by Woodrow Wilson, chaired by A. Mitchell Palmer, whose job was to seize, administer, and in some cases sell “enemy property” in the US. Palmer soon uncovered the Bayer subsidiaries that were nominally American-owned but actually controlled by Bayer’s German headquarters. He seized Bayer’s US assets and by the authority of the Trading with the Enemy Act, sold all of Bayer’s US patents, factories and trademarks, including the Bayer cross logo, bought by patent medicine company Sterling Products. The rights to “Aspirin” and the US rights to the Bayer name and trademarks were bought back by Bayer in 1994 for $1 billion. +

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