lvleschino Health Comprehensive Guide to
Reishi Mushroom Extract General Features Reishi Ít4ushroom (Ganoderma lucidum) is called "the mushroom of rnmortality" in Chna and has been used in 0rental lMedicine Íor over 2,000 years.12 ln recent years ts active ingredients have been ihe subject of intensive research regarding the r apparent ab I ty to he p prevent or treat certain types of cancer, aid in the treatment of iver disease, HIV infeclion, acute or recurrent herpetic infectons, high blood ptessure, chronic bronchits, alerges and asthma, and favorab y modulaie immune Íunction.3 The Reishi l\y'ushroom grows wld on decaying ogs and tree stumps in the coasta prov nces of China. The fruiting body of the mushroom is used med cina ly a
Principle Active Constituents 1. Specific Polysaccharldes: whlch occur ln the form of Beta-D-g ucans bound to shown to possess immune-modulat ng and ant -cancer propeflies
2. Triterpene compounds known
as ganoderic acids: which have been shown slickiness and may decrease LDL-cho esterol 5
3. other maior
an'rino acds. These agenis are
3
active consttuents include sterols, coumarin and mannitol
to owet
bLood pressure, reduce p ate et
5
Clinical Application and Mechanism of Action 1. Anti-Cancer Agent Animal cancer sludies have shown a 50% tumor regression outcome with Reishi l\lushroonr Extract treatment (e.9., connect ve t ssue cancer model in mlce).6 Reishl l\y'ushrooÍn Extract is used by some cancer surgeons in Japan to treat cancer patients and sign ficant antiluÍnor and immunostlmulalion effects have been noted in Ínany of these cases.T Po ysaccharides from re shi mushrooms and ftom other types of fo k-medic nal fungi are patented ln Japan for use as
mmunomodulators n the treatment of cancer. They are cornbined with chemo- and radiotherapy and have demonstrated an ablllty to reduce slde effects, increase the efficacy oÍ treatments, and to acceerate recovery from disease.s,e
Studies Írom China have shown lhat Reishl [,4ushroom Extract potenUates the tumoricidal capacity of macrophages and T-ce ls 101r Reishi l\lushroom Extract is known to have other immune modulating effects and antioxidant pTopedies
1213141s,16
Animal siudies a so show that the polysaccharde Íaction of re shi mushroorns can induce apoptosls (programmed celL death ofcancerce ls) in eukemic cells and nduce ce lu ar differentiation ln 40-45% of leukenric cells ireated wth reishi
polysaccharides, demonstrating sgnificant cancer treatmeni potentia These efíects were primarly due to the increased secretion of anti-tumor cytokines (signaling agents) induced by Reishi [,lushroom polysacchardes, namely TNF-alpha and IFN-gamrna, and these two cytokines acted synergisticaly on the nhibit on oí leukemic-cell growth.rT ln a related experment, the D-glucan polysaccharide fraciion of Reishi I\lushroom was shown to produce dramatic tumor Tegress on in a mice sarcoÍna study. ln many animals, compLete turnot regression occurred n the group injected wth beta-D glucan fracUons w thin a s-week period. The study by Y. Sone et al, reported iumoÍ inhibiUon rates of g0% and iumor regression in 75% oí afflcted animalsls
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