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AUGUST 8, 2019 | The Jewish Home
Extraordinary
SHABBOS NACHAMU Getaway
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United States Secretary of Energy and former Governor of Texas Rick Perry visited the Amirim Battalion Israel Defense Forces (IDF) base in Mishmar HaNegev on July 23
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a nanoparticle that can be used as a vaccine against the disease. The academics reached their conclusion after using the vaccine on mice in three separate situations: as a main form of treatment, as a cure for initial growth, and for the eradication of metastasis.
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The study was led by Professor Satchi-Fainaro, the chair of the Department of Physiology and Pharmacology and head of the Laboratory for Cancer Research and Nanomedicine at TAU’s Sackler Faculty of Medicine. Along with other researchers from the University of Lisbon, Satchi-Fainaro developed tiny particles made of biodegradable polymer, each only 170 nanometers in size. Within each particle, they “packed” two peptides – short chains of amino acids – that carry melanoma cells, and the nanoparticles were subsequently injected into the mice that were suffering from melanoma. Results showed that the particles functioned just like a virus that the mice’s immune system recognized, leading it to detect and attack the melanoma cells. “The nanoparticles acted just like known vaccines for viral-borne
diseases,” noted Satchi-Fainaro. “They stimulated the immune system of the mice, and the immune cells learned to identify and attack cells containing the two peptides — that is, the melanoma cells. This meant that, from now on, the immune system of the immunized mice will attack melanoma cells if and when they appear in the body.” Researchers say that their success marks an important breakthrough in the fight against cancer, as it is the first time that a vaccination-based treatment was shown to have been successful. While it will likely take a decade for the treatment to hit the market, the nano vaccines can potentially be used to treat other cancers as well. “The war against cancer in general, and melanoma in particular, has advanced over the years through a variety of treatment modalities, such as surgery, chemotherapy, radiation therapy and immunotherapy, but the vaccine approach, which has proven so effective against various viral diseases, has not materialized yet against cancer,” said Satchi-Fainaro. “In our study, we have shown that it is possible to produce an effective nano-vaccine against melanoma and to sensitize the immune system to immunotherapies,” continued the researcher. “We believe that our platform may also be suitable for other types of cancer and that our work is a solid foundation for the development of other cancer nano-vaccines.”