3D reconstruction of a light-sheet fluorescence microscopy-examined murine heart after myocardial infarction. Immune cells (here macrophages) that have invaded the tissue as an inflammatory response to the myocardial infarction, and regulate the tissue healing on site, light up in red-yellow.
BIO-IMAGING Modern imaging techniques have long been regarded as a key technology for first-class medical research. At ISAS, the »Bio-Imaging« research programme focuses on the imaging of temporal and spatial molecular dynamics in organisms ranging from individual cells up to entire organs. For example, the scientists are using light sheet fluorescence microscopy (LSFM), raman microscopy and coherent anti-stokes raman scattering (CARS) microscopy to validate biomarkers in order to accelerate the early detection of various diseases such as cardiovascular diseases or autoimmune diseases. Close cooperation with the Institute for Experimental Immunology and Imaging at the University Hospital in Essen, among other things, should ensure that the results of this basic research can later be translated into the clinic, i.e. transferred from the laboratory to patient care. ISAS
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ANNUAL REPORT 2021
