BIOMARKERS
An open high performance liquid chromatograph (HPLC) is not an uncommon sight for Ingo Feldmann. As head of the Technical Service Bioanalytics, he and his team are experienced with this highly sensitive equipment.
Analytical methods that simultaneously map information on different classes of molecules and their spatial distribution patterns are needed in order to understand when and where in the body the biological decision between disease and health is made. The aim of the work in the research programme of the same name is to identify biomarkers for early diagnosis or personalised therapy using 4D analytics. Reliable markers expand the possibilities of evidence-based diagnostics in modern medicine, allowing for differentiated and individualised therapy. Marker-based diagnoses make it possible to classify diseases into subtypes and thus to specifically adapt treatments for individual patients.
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Biological markers can be all sorts of mo-
signalling pathways within a cell or in
lecules, large or small. For example, amino
tissues. Researchers at ISAS are working to
acids, lipids and metabolites can be used to
identify, investigate and validate biomarkers
make specific statements about metabolic
for various disease patterns and stages. The
changes and the modulation of protein func-
»Biomarkers« research programme focuses
tions. Proteins often serve as markers for
on markers for use in cardiovascular
the alteration of cellular structures,
diseases, cardio-oncology and diseases such
ANNUAL REPORT 2021
