Run a Successful Drug Discovery Program with In Vitro Toxicity Testing Methods
Adverse effects due to drug toxicity are some of the main reasons for drug failure in the clinic. The goal of running an in vitro toxicity testing program is to reduce late stage drug failure through the early identification of compounds likely to cause adverse effects in humans or animals.
If compounds likely to cause toxicity in vivo are identified early through in vitro methods drug developers save months, potentially years, of time spent developing a compound that will inevitably fail in the clinic.
With this time savings also comes the cost savings of over investing in expensive in vivo or animal studies. Discovering a compound is toxic in cells is much more affordable and time efficient than discovering a compound is toxic in animals, not to mention more ethically acceptable. The typical turnaround time for an initial in vitro toxicity screen (Cell viability) is around a week. A similar study in vivo could take months, in some cases, take years because the animals need to be developed for the study. Thereby, for ethical reasons and the highly expensive nature of the In Vivo tests the pharmaceutical
industry relies on in vitro techniques for toxicity testing, particularly in early drug discovery.
Choosing a Contract Research Organization (CRO) to perform In Vitro Toxicity Testing
Ensure the success of your drug discovery program with IONTOX’s world-class in vitro toxicology services. IONTOX is highly specialized in in vitro methods with over 35 years of combined experience in drug discovery and runs all of the standard in vitro assays needed to operate a successful drug discovery program .
In vitro toxicity assays bring numerous technical benefits which include: the ability to understand cellular-response networks and toxicity pathways; the usage of concentrations relative to exposure; and enabling of high-throughput studies to look at many compounds for viability.
IONTOX’s in vitro toxicity testing services includes cytotoxicity screens, 3D tissue models for OECD compliant irritation studies, and even extends to being able to predict in vivo toxicity in animals. To predict systemic toxicity in humans a meso-scale, human based, flexible HuDMOP™ platform is utilized.
So, choose a well-established CRO – IONTOX for world-class In Vitro Toxicity Testing.
For more information regarding innovative In Vitro Toxicity Testing, visit https://www.iontox.com/in-vitro-toxicity-testing/ today.