Thank you to our sponsors!
Topics to be covered
ASCO 2023 Annual Meeting – June 2-6, Chicago
IMWG Summit – June 7-8, Frankfurt
EHA 2023 Hybrid Congress – June 9-12, Frankfurt
Notable Event: 2023 Kyle & Durie Achievement Awards
Top Abstract
at ASCO and EHA (Plenary)
• Cilta-cel (CAR T) v SOC in Early Relapse presented during the Special CAR T Session at ASCO 2023
• Impressive results: Progression risk reduced by 74%
• Companion NEJM Publication: Points to use of CAR T in Earlier Disease
Impact of CAR T Therapy: CARTITUDE-4
RESULTS versus RRMM results (CARTITUDE-1)
ASCO: Main Oral Session
Saturday, June 3
• Abstract #8000: KRd vs Elo KRd in NDMM
• Abstract #8001: KPd maintenance in High-risk MM
• Abstract #8002: Teclistamab + Talquetamab (RedirecTT-1)*****
• Abstract #8003: Talquetamab + Dara (TRiMM-2)
• Abstract #8004: Phase 1 CAR T: PHE 885
• Abstract #8005: Rapid CAR T dual target – Shanghai experience
• Abstract #8006: Bispecific Regeneron #5458 (LINKER-MM1)
• Abstract #8007: DREAMM-3 Bela versus Pom dex F/U
• Abstract #8008: Bispecific Elranatamab: MagnetisMM
*****Will be discussed in full
Additional ASCO Presentations
SPECIAL POPULATIONS: Age/Disparities/Renal Compromise
Meet the Prof on Bispecifics: Moreau/Garfall
Wide range of topics
ORALS/POSTERS
EHA 2023 Presentations
Over 200 interesting/important Myeloma Abstracts!
Some TOP ABSTRACTS are also from ASCO 2023
Many unique presentations that are impossible to summarize:
Immune therapies (CAR T/Bispecifics)
Combinations
Real-world findings
Patient Preferences
Infections QoL DREAMM studies
Master Trial
Selinexor combos
Zometa 4 years
Young outcomes
Telomeres
EMD
Arginine Deprivation
MRD Surrogacy
Turning to IMWG Summit Key Discussions
Smoldering Multiple Myeloma Committee Report
María-Victoria Mateos, MD, PhD
University of Salamanca, Spain
Shaji Kumar, MD Mayo Clinic
Endpoints for trials
• What would be the right endpoint for trials?
– Overall survival is the gold standard but will take many years to find the benefit
• Progression free survival?
• Sustained MRD negativity? If so, how long?
• HRQOL endpoints?
Combined Mass Spectrometry & MRD Committee Report
Mass Spectrometry
Brian G.M. Durie, MD
International Myeloma Foundation
David Murray, MD, PhD
Mayo Clinic
MRD
Nikhil Munshi, MD
Dana-Farber Cancer Institute
Bruno Pavia, PhD
University of Navarra
Mayo Update
• Performed over 200,000 tests by Mass Spec since 2018
– Retrospective review of first 20,000 tests published (Mayo Clinic Proceedings)
• Urine Mass Spec is clinically available as of two weeks ago
– Equal sensitivity to urine IFE without concentrating the urine
– Improved specificity as mass of light chains consistent with serum
• Elimination of SPEP Dec 2023
Literature Update
• Several New Papers using a targeted CDR M-protein peptides for MRD
– “Easy M” test from University of Washington in St. Louis
–
Sebia/Erasmus University MRD
• Detection in Non-Secretory MM (Giles et al Blood)
• Low-Cost Method using MALDi-TOF (Mehra et al)
Commercialization Update
• Europe planned for August 2023
• USA planned for Q1 2024
Why Mass Spec could be routine in
most labs
• Lab workflow/through put is significantly increased
–
Mayo has tripled the number of results per lab tech for IFE
– This will increase again on replacement of SPEP
• Current cost for U.S. Medicare patients is only 25% of a serum
rFLC determination
• Detection of other new entities and diseases
–
IgG4 RD patterns are recognizable by this method
– Replacement for oligoclonal banding for MS
–
M-protein light chain glycosylation
•
Amyloidosis
• Cold Agglutinin Disease
Guidelines to use MRD in clinical practice
Methods
IMWG Summit Takeaways
Many new projects (Registry/Biobank)
Publications pending/planned
New Areas of Focus:
o Infections and 2nd cancers
o QoL/Patients’ Perspective & Preferences
o Real-world role of MRD and Mass Spectrometry
o Many others for F/U before ASH Breakfast Meeting
“The Plasma Cells” IMWG Band
Zamagni,
Zweegman, MD, PhD; Philippe
MD; Paula Rodríguez-Otero, MD, PhD
Video Replay
A replay of the webinar will be made available on our website early next week. You can find it under the Publications and Videos Tab. A replay link will be directly emailed to all who registered for this webinar.
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Feedback Survey
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