Myeloma Acronyms and Abbreviations

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Myeloma Acronyms and Abbrevia2ons

updated March 2021

ACRONYM

MEANING

ADC

An1body-Drug Conjugate

Allo

Allogeneic Stem Cell Transplant

Auto

Autologous Stem Cell Transplant

ASCT

Autologous Stem Cell Transplant

β2M, β2M

Beta-2 Microglobulin

BCMA

B-cell Matura1on An1gen

BiRd

Biaxin + Revlimid + Dexamethasone

BiTE

Bispecific T-cell Engagers

BMT CTN

Bone Marrow Transplant Clinical Trials Network

BP

Bisphosphonate

CALGB

Cancer and Leukemia Group B (a US coopera1ve clinical trials group)

CAR T

Chimeric An1gen Receptor (CAR T-cell therapy)

CBC

Complete Blood Count

CD34

Cluster of Differen1a1on 34 (a cell surface protein on hemtopoie1c stem cells)

CD38

Cluster of Differen1a1on 38 (a cell surface protein on hematopoie1c stem cells)

CI

Confidence Interval (sta1s1cal term)

CR

Complete Response/Remission

Cr

Crea1nine

CRAB

Calcium Renal Anemia Bone Disease

CRP

C-reac1ve Protein

CRS

Cytokine Release Syndrome

CT

Computerized Tomography Scan (3D X-ray)

CyBorD

Cytoxan + Velcade (bortezomib) + Dexamethasone

DCEP

Dexamethasone + Cyclophosphamide + Etoposide + Cispla1n

DEX

Dexamethasone

D-PACE

Dexamethasone + Cispla1n + Adriamycin + Cyclophosphamide + Etoposide

DVD

Doxil + Vincris1ne + Dexamethasone

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Myeloma Acronyms and Abbrevia2ons

updated March 2021

DVT

Deep Vein Thrombosis

EFS

Event Free Survival

EMD

Extramedullary Disease (myeloma that grows outside the bone marrow)

FISH

Fluorescence In Situ Hybridiza1on

FLC

Free Light Chain (kappa or lambda)

GEP

Gene Expression Profile

GIMEMA

The Italian myeloma clinical trials group

GMMG

The German myeloma clinical trials group

GVHD

Gra_-versus-Host Disease

HDAC

Histone Deacetylase

ACRONYM

MEANING

HDT

High-Dose Therapy

HOVON

The Dutch clinical trials myeloma group

HR

Hazard Ra1o (sta1s1cal term)

HRSMM

High-Risk Smoldering Mul1ple Myeloma (high-risk features include t(4;14), t(14;16), 17p-, 1q+)

IEP

Immunoelectrophoresis

IFE

Immunofixa1on Electrophoresis

Ig

Immunoglobulin

IM

Intramuscular (shot or infec1on into the muscle)

ISS

Interna1onal Staging System

IV

Intravenous (injec1on into the vein)

IVIG

Intravenous Immunoglobulins

KRD

Kyprolis (carfilzomib) + Revlimid (lenalidomide) + Dexamethasone

MEL 200

The dose of melphalan administered in ASCT: 200 mg of melphalan per square meter of body mass

MGUS

Monoclonal Gammopathy of Undetermined Significance

MP

Melphalan + Prednisone

MPR

Melphalan + Prednisone + Revlimid (lenalidomide)

MPT

Melphalan + Prednisone + Thalidomide

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Myeloma Acronyms and Abbrevia2ons

updated March 2021

MR

Minimal Response (between 25% and 50% response to a drug or regimen in a clinical trial)

MRC

Medical Research Council (UK myeloma clinical trials group)

MRD

Minimal Residual Disease

MRI

Magne1c Resonance Imaging

mSMART

Mayo Stra1fica1on of Myeloma and Risk-Adapted Therapy

MTD

Maximum-tolerated Dose

NA or N/A

Not Available

nCR

Near-Complete Response

NDMM

Newly Diagnosed Mul1ple Myeloma

NGF

Next-Genera1on Flow (new 8-color flow cytometry test with so_ware for myeloma)

NGS Nex

Next-Genera1on Sequencing (new DNA-sequencing test)

NR

Not Reached

ONJ

Osteonecrosis of the Jaw

ORR

Overall Response Rate

OS

Overall Survival

PAD

Velcade (formerly PS-341) + Adriamycin + Dexamethasone

PBSCT

Peripheral Blood Stem Cell Transplant

PCLI

Plasma Cell Labeling Index

PCR

Polymerase Chain Reac1on (DNA test, also called ASO PCR or AleeleSpecific Oligonucleo1de PCR)

ACRONYM

MEANING

PET

Positron Emission Tomography

PET/CT

PET combined with a CT scan

PETHEMA

The Spanish myeloma clinical trials group

PFS

Progression-Free Survival

PN

Peripheral Neuropathy

PR

Par1al Remission/Par1al Response

REVLoDEX

Revlimid (lenalidomide) + Low dose Dexamethasone

R-ISS

Revised Interna1onal Staging System

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Myeloma Acronyms and Abbrevia2ons

updated March 2021

RMPT

Revlimid (lenalidomide) + Melphalan + Prednisone + Thalidomide

RRMM

Relapsed/Refractory Mul1ple Myeloma

RQPCR

Real-1me Quan1ta1ve Polymerase Chain Reac1on (DNA test)

RVD

Revlimid (lenalidomide) + Velcade (bortezomib) + Dexamethasone

sCR

Stringent Complete Response (CR plus normal free light chain ra1o and no clonal plasma cells)

SCT

Stem Cell Transplant (aka High-Dose Therapy with Stem Cell Rescue)

SD

Stable Disease

SINE compound

Selec1ve Inhibitor of Nuclear Export, or SINE compound

SMM

Smoldering Mul1ple Myeloma

SPM

Second Primary Malignancy

SQ

Subcutaneous (also abbreviated as SC)

SRE

Skeletal-related Event

TMI

Too Much Informa1on

TTP

Time to Progression

VAD

Vincris1ne + Adriamycin + Dexamethasone (old standard induc1on therapy)

VAMP

Vincris1ne + Adriamycin + Methylprednisolone

VCF

Vertebral Compression Fracture

VDT-PACE

Velcade + Dexamethasone + Thalidomide + Cispla1n + Adriamycin + Cyclophosphamide + Etoposide

VEGF

Vascular Endothelial Growth Factor

VGPR

Very Good Par1al Remission

VRd

Velcade + Revlimid + Low-dose Dexamethasone

VTD

Velcade + Thalidomide + Dexamethasone

WBLD CT

Whole-Body Low-Dose CT

WBLD MRI

Whole-Body Low-Dose MRI

XGeva

Denosumab

ZOL

Zoledronic acid (Zometa®)

myeloma.org

818-487-7455 worldwide • 800-452-CURE (2873)

toll-free in US & Canada