





Leadershipisnotdefinedbyposition—it’sdefinedbypurpose.
Andin2025,theentrepreneuriallandscapeintheUnitedStates isbeingtransformedbyapowerfulforce:womenwhoarenot justbuildingbusinesses,butreshapingindustries,empowering communities,andsettingnewstandardsforwhatsuccesslookslike.
USA’s Ten Most Impactful Shepreneurs to Watch in 2025 isa celebrationofboldvisionaries,changemakers,andtrailblazers.These arewomenwhohavesteppedintothearenawithcourage,conviction, andrelentlessdrive.Whethertheyaredisruptingtechnology,redefining wellness,revolutionizingfinance,orinnovatinginthecreative arts—eachoneofthemcarriesastoryofgrit,impact,andleadership thatdeservestobeseenandheard.
Thisfeatureismorethanalist—it’satributetoresilience,innovation, andpurposefulgrowth.Thesewomenhavenotonlycarvedaspacefor themselvesinhighlycompetitiveenvironments,buthavealsocreated opportunitiesforothers,challengedoutdatednorms,andinspiredthe nextgenerationofentrepreneurs.Theyarementors,rolemodels,and forcesofpositivedisruption.
WhatmakestheseShepreneursstandoutisn’tjustthesuccessoftheir ventures—it’stheintentionbehindtheirimpact.Theyleadwith empathy,scalewithvision,andgrowwithintegrity.Theyunderstand thatbusinesstodayisaboutmorethanprofit—it'saboutinfluence, value,andlegacy
Theirjourneysreflectabroaderculturalshift—onewherewomenare notjustparticipatingintheentrepreneurialeconomy,butareactively shapingitsfuture.Inboardrooms,investormeetings,andstartup incubatorsacrossthecountry,theirvoicesaredrivingchangeand creatingmeaningfulimpact.
Thiseditionisdedicatedtotheirstories—tothebarriersthey’ve broken,theideasthey’vechampioned,andthefuturesthey’rebuilding. ThesearetheShepreneurswebelievetheworldshouldbewatchingin 2025—andbeyond.
Theirtimeisn’tcoming.It’salreadyhere.
A Modern Relationship Builder: Paula Panagouleas Miller Passionately Helping People Cultivate Great Relationships with Karmascore
Disruptive Leadership: Breaking Barriers to Build Better Futures
The People-Centered Leader: Where Empathy Meets Impact
Art
Business
Business
Digital
Co-designer
Marketing
Adela Jamal Founder Featuring milemark•capital milemark.capital.com
Amanda DeLuca Co-founder
Amanda Victoria Co-founder & CEO
Kate Walsh Founder
Mayssa Chehata Founder & CEO
Riley rileyapp.com
Siponey Spritz Co. B Corp siponey.com Boyfriend boyfriendperfume.com
BEHAVE Candy eatbehave.com
Melanie Masarin Founder & CEO Ghia drinkghia.com
Nisha Dua General Partner
Paula Panagouleas Miller Founder and CEO
Soraya Darabi General Partner
BBG Ventures bbgventures.com
Karmascore karmascoreapp.com
Xiomara Wilson CEO and Founder
TMV tmvvc Pressiqa pressiqa.com
Adela brings a dynamic blend of strategic insight, financial acumen, and purposeful inves ng to the venture capital ecosystem.
Under Amanda's leadership, Riley helps organiza ons foster thriving workplace cultures by addressing engagement, reten on, and well-being with data-driven precision.
With a background in luxury spirits and communica ons, Amanda brings over a decade of experience and passion for conscious consump on to the forefront of the beverage sector.
Best known for her celebrated ac ng career, Kate expanded her crea ve footprint by stepping into the world of beauty and entrepreneurship with the launch of Boyfriend—a unisex scent inspired by memory, in macy, and individuality.
With a background spanning law, marke ng, and growth roles at powerhouse brands like Uber, SoulCycle, and Daily Harvest, Mayssa combined her strategic acumen and personal passion to launch BEHAVE in 2020.
Under Melanie’s leadership, the brand has grown into a cultural symbol—celebrated for its clean ingredients, elegant aesthe cs, and inclusive approach to celebra on.
Under her leadership, BBG Ventures has backed trailblazing companies such as Zola, Blueland, and The Wing—businesses reshaping their categories and priori zing impact alongside profit.
With an innova ve concept that gamifies behavior pa erns and interpersonal accountability, Paula is pioneering a new category of wellness technology grounded in empathy, transparency, and self-improvement.
Soraya Darabi exemplifies the power of strategic capital aligned with global impact. Her work at TMV is not just about returns—it's about reshaping industries for good.
With a keen understanding of today’s fast-paced digital media landscape, Xiomara launched Pressiqa to democra ze access to powerful, press-ready visibility tools that help brands break through the noise.
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One of the most de ning moments was when a young woman wrote to us saying Karmascore helped her recognize a pattern of emotional manipulation in her long-term relationship.
and CEO
Throughhercareerinmanagingglobalteamsofmultimillion-dollar Fortune 500 companies in the banking, investment, and corporate industry, Paula Panagouleas Miller understood the crucial logic of life’s balance sheet. Your emotional, and thus, effectively, your physical health and well-being are directly proportional to many vital factors, including one of the most important, whichisyourrelationships.
Paula spent over a decade in corporate finance, managing multimillion-dollar portfolios and leading diverse teams. That experience, combined with her education at Harvard, taught her how to build systems, analyze risks, and drive results.Butmoreimportantly,itshowedhertheemotionaltoll of poor leadership and toxic relationships in the workplace Her personal life—as a wife, mother, author, and certified relationship coach—reinforced the importance of empathy, boundaries, and emotional intelligence. These insights became the foundation of Karmascore, which empowers userstoreflectonhowtheirrelationshipsmakethemfeelover time.
“ “ Years later, inspired by the complexities of modern relationships and my background in ( nance) analytics, I created Karmascore—an app to help people better manage and evaluate the relationships that shape their lives
Paula’sentrepreneurialjourneybeganoutofnecessity When she was in college, her mother became seriously ill and couldn’taffordhermedications.Tosupporther,Paulastarted collecting items that other college students discarded at the endofeachsemesterandresoldthemthefollowingterm.That small initiative turned into a profitable resale business and gaveherthecapitaltolauncharealestatecompany,whichshe eventuallysold.
“That experience taught me that resilience, resourcefulness, and purpose can birth something powerful,” reflects Paula, who—inspired by the complexities of modern relationships and her background in (finance) analytics, created Karmascore an app to help people better manage and evaluatetherelationshipsthatshapetheirlives.
As a Harvard graduate, Paula has always been driven by a desiretomergedataandhumanitytomakelifebetter.
At the heart of every meaningful connection is a conscious investmentoftime,energy,andcare.Paula,thedynamicCEO of Karmascore and a Certified Relationship Coach, has made it her life’s mission to help people cultivate stronger, healthier, and more fulfilling relationships—both personally and professionally. With a passion rooted in empathy and a mind sharpened by decades of business leadership, Paula brings a unique fusion of emotional intelligence and analyticalprecisiontotheworldofrelationships.
Paula’s entrepreneurial spirit has never been onedimensional. Before founding Karmascore, she built a formidable career in the private sector In parallel, she nurturedherentrepreneurialspiritbylaunchingandgrowing severalsuccessfulself-startedbusinesses.ShewastheChief Executive Officer at Advice and Spice, where she was the authorized relationship and dating coach, helping people buildgoodrelationships.
I hope my journey shows that you don’t have to wait to be invited, approved, or validated. Build the thing. Start the conversation. Take up space. “ “
Also,duringthosetwoyears,shecompletedherfirstbook,Oh My, Oh Me! Where Is My Buzz, Buzz, Bee? Later, she publishedthreemorechildren’sbooks:
ILoveYouMore
MySweetestArlo
IWish
Karmascore:TransformingRelationshipHealth
Today,shechannelsallofthatexperienceintoKarmascore,an award-winning relationship analytics company that’s transforming the way people understand and manage their socialecosystems.
Karmascore is more than an app it’s a tool for selfawareness and relationship alignment. It empowers users toevaluateandtracktheirrelationshipsviamemories,money, andmilestones.
Pauls shares, “With Karmascore, anyone can keep up with important relationships. We create healthier relationships with interpersonal connections informed by data! Karmascore is now available for download on Google Play and the Apple Store. Look for more information at karmascoreapp.com.”
Karmascore’s mission is to improve the quality of people’s lives by helping them reflect on, prioritize, and strengthen their most important relationships romantic, platonic,
familial, and professional. The app lets users log memories, trackrelationshippatternsovertime,andreceiveinsightsand recommendations.Paulaclarifies,“We’re not a dating app or a journaling tool—we’re the first true relationship analytics platform. Our values—honesty, accountability, growth, and kindness—guide everything from product design to customer support. What sets us apart is our belief that people should invest in relationships as they invest in physical and mental health.”
Karmascore is driving impact by sparking a new category: relationship health. It is giving users data-backed ways to recognizeredflags,appreciategreenflags,andcommunicate moreintentionally.Paulainformsthattheyalsopartnerwith universities, therapists, and content creators to normalize emotionalcheck-insandreducethestigmaaroundrelational pain.It’stechthatnurtures,notnumbs.Shecreditshertimeat Harvard for helping her develop a mindset that values innovation not just for novelty’s sake but for human wellbeing.
The true impact of the app is deeply personal. Sharing a successful result of the app, Paula says, “One of the most defining moments was when a young woman wrote to us saying Karmascore helped her recognize a pattern of emotional manipulation in her long-term relationship. She told us the app gave her clarity and courage to leave.” It remindedherwhytheyexist—nottojudgerelationshipsbut tohelppeoplefeelseen,supported,andstronger.
Paula’s leadership philosophy is rooted in transparency, autonomy, and trust. She believes in hiring people smarter than her and then giving them the space to excel. She prioritizes clarity over control and kindness over ego. This approach creates a culture where team members feel safe to shareideas,takerisks,andsupporteachother.“Italsomirrors how we want our users to feel—safe, seen, and empowered in theirrelationships.”
Asafemalefounderintech,Paulahasoftenhadtoprovethe validity of a problem men didn’t always relate to relationship overwhelm, emotional burnout, and the invisiblelaborofcare.She’sbeenunderestimated,
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“ Karmascore’s mission is to improve the quality of people’s lives by helping them re ect on, prioritize, and strengthen their most important relationships—roman tic, platonic, familial, and professional.
interrupted, and second-guessed. But instead of letting it breakher,sheuseditasfuel.Shelearnedtoadvocateclearly, pitchfearlessly,andleadunapologetically Theseexperiences shaped her leadership philosophy: lead with clarity, compassion, and courage—especially when the room isn’t builtforyou.
Further, in moments of uncertainty or high-stakes decisionmaking,Paulastaysgroundedbystayingclosetoherpurpose. She revisits messages from users who’ve found healing through Karmascore. She leans on her husband, who’s a brilliant professor and her best friend. She spends time with herkids,whosejoyisadailyreminderofwhatreallymatters. She works out. It’s a great resource. As for inspiration, she stays curious. She reads, listens, walks, reflects, and lets herselfbemovedbyeverydaymoments.Shealsocreditsher Harvardeducationthatinstilledinheralifelongcommitment to learning, and that mindset helps her navigate complexity withcalmandconfidence.
Thus, using her vast repertoire of experiences, Paula now empowers other women, professionals, and aspiring entrepreneurs through her work, mentorship, and public
voice. She talks publicly via social media about relationship health,startuplife,andtheuniquepressurewomenfaceto"do itall."Sheisopenaboutherwinsandherfailuresbecauseshe wants to normalize the messy, nonlinear path to success. Through Karmascore, she also creates content that encourages self-worth, emotional awareness, and healthy boundaries—topicsthatdisproportionatelyaffectwomenand areoftenoverlooked.
For the aspirants, especially in industries or spaces where female leadership is still emerging, Paula hopes her journey showsthattheydon’thavetowaittobeinvited,approved,or validated. Build the thing. Start the conversation. Take up space. Female leadership doesn’t have to mimic traditional power structures to be effective. “In fact, the most powerful leaders I know lead with empathy, intuition, and collaboration.Weneedmoreofthat.Weneedmoreofus,”she insists.
OutsideoftheboardroomofKarmascore,Paulaisanauthor,a passionate advocate for emotional education, a proud wife, andamom.“I’mdeeplycommittedtohelpingbuildemotional intelligence. I’m also passionate about empowering immigrants and first-generation families—my father came to the U.S. from Greece with nothing but grit and dreams.”That legacyfuelsher
YouDon’tNeedPermission—JustPassion
In her piece of advice to aspiring entrepreneurs, especially those hesitant to take the first step, Paula says: Start messy. You’llneverfeelfullyready,andwaitingforperfectionisjust fearindisguise.Focusontheproblemyou’resolvingandthe people you’re serving Talk to them Build with them Remember: rejection is redirection. Every no teaches you something.Everyobstaclebuildsresilience.Keepgoing.You don’t need to have it all figured out—you just need to care enoughtobegin.
Leadershiptodayisnotaboutsustainingthestatusquo—it'sabout disruptingit.Inaworldofturbulence,acceleratedchange,andrising expectations,traditionalleadershiptheoriesareincreasinglyless relevant.Thepeoplewhoarereallydoingsomething—disruptingiton purpose—arenotthosepeopleplayingitsafe,butthedisruptorswhoare leading.
Welcometotheageofdisruptiveleadership—afuturistic,innovativestyle wherecourage,creativity,andconsequenceintersect.Disruptiveleadersare agentsofchangewhonotonlyrespondtochange,butdeliberatelyengineerit, frequentlypriortoitsnecessitybeingobvious.Theybreakapartthestatusquo, challengeinheritedknowledge,andcreatenewfieldsofactionthatredefine what'spossibleforbusinesses,communities,andsocietyasawhole.
Disruptionstartswithdiscomfort.Disruptiveleadersknowthatgrowthdoesn't happenincomfort—ithappensinchallenge.Theydon'tacceptincremental solutions.Theyposethehardquestionsinstead:Whyisthisso?Whoisbeing leftout?Whatifwestartedover?
Thisattitudeisnotcareless;itisvisionaryandpositive.Theseleadersare attunedtoinefficiencies,imbalances,anduntappedpotential—andalsotothe strengthtoresistthemhead-on.
Theyrealizethatbreakingbarriersisaprocessofsometimesbreakingoutofthe norm,andthey'rewillingtomeetresistanceinsteadofsidesteppingit.
Disruptionisn'tfordisruption'ssake.It'smission-driven.Thegoalisn't anarchy—butimprovedresults:smartersystems,moreinclusivesolutions,and moresustainableprogress.
Disruptiveleadersareinnateinnovators.Theylookaroundcorners,predict trendsbeforetheymaterialize,andtransformnewchallengesintocompetitive strengths.Theydon'tjustadopttechnology—theyreimaginehowitcanreshape businessmodels,industries,andthehumanexperience.
WhethertheyareapplyingAItocustomizehealthcare, creatingcirculareconomiesforsustainability,or transformingeducationthroughEdTech,disruptiveleaders employinnovationasaforceofinclusivity,flexibility,and long-termvalue.They'renotmerelysurfingthewaveof digitaltransformation—they'recreatingit.
Undersuchleaders,innovationisnotlimitedtoproductsor services.Itisinthewayteamsworktogether,decisionsare made,andimpactisgauged.Theybuildorganizations whereexperimentationisencouraged,failureisalwaysa moveforward,andcreativitycanflourishatalllevelsofthe organization.
Oneofthedefiningfeaturesofdisruptiveleadershipisan unwaveringcommitmenttoequityandinclusion.Such leadersrecognizethathomogeneitykillsperspectiveand creativity Theyarecontrastedwithpluralteamsthatbring togetherbroaderviews,moreempathy,andgreater problem-solvingmuscle.
Disruptiveleadersproactivelydismantlewallsto opportunityandaccess.Theyadvocateforunheardvoices, dismantlesystematizedbias,andcreateworkplaceswhere differenceisanassetthatfuelsexcellence.Bydoingso, they'renotmerelyachievingcompliance thresholds—they'recreatingspacesinwhicheveryhuman canmakeahugeimpactandexpandexponentially
Thisemphasisoninclusionisnotmerelyethical—it's strategicallynecessary.Adiverseworld,asthefutureworld willbe,willbeconstructedbythosewhoareworld-aware andattunedtoaworld'sneeds.Disruptiveleadersmake surethattheinnovationtheycreateisofandintheworld they'rein.
Disruptiveleadershipisnotforeverybody.Challenging existingnormsmeetswithcriticism,skepticism,and pushback.Butthegreatestdisruptorsarenotdeterredby conflict—rather,theyareenergizedbyit.Theyunderstand thattensionisasignofmovementandthattruechangeis frequentlytheoffspringoffriction.
Resiliencethusbecomesapriority.Disruptiveleadershave abuilt-incompassthatcallsthemtostayfirmontheir purposeevenwhenuncertain.
Theyareemotionallyaware,dynamic,andunflinchingin theirpurposeinthefaceofunclearoutcomesorlong-term results.
They'realsoinclusive,havingthewisdomtoknowwhento listen,toturn,andtobringothersalongfortheride. Disruptionisnotoneperson'sgame—ittakescoalition building,narrative,andthecapacitytotakebigideasand turnthemintoaction-orientedmomentum.
Realdisruptiveleadershipisnotgaugedbymarketshareor public-relationsbuzzalone.It'sgaugedbyitsimpact—on people,onsystems,onthefuture.
Disruptiveleadershavealongtermview.Theyarenotonly interestedinquarterlyperformancebutincreatinglegacies oflong-termvalue.Theyaskthemselves,"Whatdowe leavebehind?"and"Howarewecreatingafuturethat peoplecanbuildon?"
Whetherremakingeducationaccess,reconceivingaging infrastructure,orbuildingmoreresponsiblesupplychains, theseleadersdon'tjustleavebehindtraumatized markets—theyleavebehindrenewedoptimism,greater opportunity,andchange.
Conclusion:ACallforCourageousLeadership
Theworlddoesn'trequiremoremanagersofthefamiliar. Theworldrequiresarchitectsoftheunfamiliar—people whoarewillingtochallenge,whowillact,andare dedicatedtoconstructingbetterfutures.Disruptiveleaders areexactlysuchpeople.Theyareconfidentbutnot arrogant,visionarybutnotlackinginrecall,and compassionatebutnotpassive.Theyconstructbridges whereotherslookforwallsandunlockwaysforwardwhen therouteisobscure.
Asweenteraworldofspeedingchangeandpressingcrises, disruptiveleadershipisn'tacompetitiveadvantage—it'sa leadershipimperative.
Becausethefuturewon'tbeinherited.Itwillbecreated—by thosewho'llbewillingtodisrupt.
Inatimeofvolatility,complexity,andconstantdisruption,theleadership attributesthatdefinedgreatleadershipinthepast—command,authority,and control—arenolongersufficient.Themosteffectiveleadersarenolonger themostvocalorthosewhorulebyedict,butthosewholeadwithcompassion, authenticity,andpurpose.
Thisshiftisthearrivalofthepeople-firstleader:aleaderwhounderstandsthat whenpeoplewin,organizationswin.It'samodelofleadershipwhereempathy isn'tasupposedsoftskill,butastrategicimperative—onethatignites engagement,trust,andsustainedoutcomes.
RedefiningEmpathyinLeadership
Leadershipempathyisnotamatterofemotionorevenlikability—itisabout deepunderstandingandintentionalconnection.It'stheabilitytoseethrough otherpeople'seyes,listenwithanopenheart,andreplywithhumanity. Practicingempathyenablesleaderstogetthroughduelingperspectives,leadin uncertainty,andguideteamsthatfeelincludedandbelonging.
Evidenceatteststoitsvalue.Fromnumerousglobalstudies,empatheticleaders havegreateremployeeretention,resilience,teamwork,andperformance. Empatheticleadershipcreatespsychologicalsafetyintimesofcrisis—a requirementforinnovationandadaptability
Empathyaloneisnotenough.Combinedwithclarity,decisiveness,and accountability,itbecomesanimpactmultiplier
TheIntersectionofEmpathyandImpact
People-focusedleadershipdoesn'tcomeatthecostofperformance—itboostsit. Empatheticleaders'organizationsreapbothtangiblebusinessbenefits:stronger cultures,enhancedcustomerinteractions,andsustainedproductivity improvements.
Suchleadersarenotafraidtoaskquestionslike:
• Howdoourdecisionsaffectourpeople?
• Arewecreatingacultureoftrustorfear?
• Howareourbuildingthewholeperson,notjusttheprofessional?
Bycenteringonhumans,theycreatecontextswherepeople feelempoweredtoperformattheirbest,notoutof obligation,butbecausetheychooseto.Suchasenseof purposeandalignmentiswhatcreateshigh-performing teamsandenduringorganizationalsuccess.
Oneofthemostunderusedandmostpowerfultoolsofa people-orientedleaderistheartofactivelistening.Ina noisyworld—emails,meetings,deadlines—makingroom toactuallyhearisbothrareandradical.
Listeningisnotjusthearingwords—it'shearingconcerns, voicingunderstanding,andopeningdoorstoopen conversation.Whenleaderslisten,trustisestablished. Whentheyactonwhattheyheard,credibilityis established.
Thispracticealsosparksinclusiveleadership.Bycreating spaceforvariousvoicestoinput,people-drivenleaderssee farther,clearblindspots,andmakebetterdecisions.It'snot beingthepurveyorofallthesolutions—it'saboutbeing responsive,present,andcurious.
Today'sorganizationsarecontinuallynavigating change—beitdigitaltransformation,changestothe workforce,orworldcrises.Insuchtypesofenvironments, people-centricleadershipisurgentlyneeded.
Ratherthandictatingchangefromabove,theseleadersare collaborativechange-makerswiththeirrespectiveteams. Theycommunicatethe"why,"addressanxietythrough empathy,andensurethatpeoplefeelinvolvedand informed.Thisresultsingreateralignment,lessresistance, andgreaterresilience.
Muchmoreimportantly,people-centeredleadersrecognize thatchangedoesn'ttakeplaceinworkflowsbutinminds andhearts.Theyarebytheirpeopleduringtheemotional andpsychologicalstagesofchange,andtheymake wellbeingandperformancehandinhand.
Anothercommonmythsurroundingempathyisthatit becomesincreasinglydifficulttomaintainascompanies grow.Butwiththerightstructuresandmindset,empathyis completelyscalable.
People-firstleadersdesignprocessesthatembedempathy intothefabricoftheorganization—beitonboardingand performancereviews,communicationandfeedback,or recognitionandreward.Theybuildteamsboundbyvalues andequipmanagerstoleadwithempathyandsimplicity Maybemostimportantly,theythemselvesexhibit empathy—arippleeffectthatflowsthroughoutthe organization.
Thishuman-firstapproachdoesnotmeansacrificingspeed orresults.Instead,itensuresthatgrowthissustainable, values-based,andshared—attributestoday'stalentand customersexpectfromthebusinessestheyinteractwith.
Authenticityisattheforefrontofpeople-centricleadership. Greatleadersdon'tfakeperfection—theyarecourageous enoughtobevulnerable,toadmitwhentheydon'tknowit all,andtosharetheirownlearningjourneys.
Thiskindoftransparencybreaksdownboundariesbetween "employees"and"leaders."Itreplaceshierarchywith humanity,powerwithpartnership.Itdoesthisby encouragingotherstoshowupwiththeirwholeselves,take ownershipoftheirwork,andleadfromwherevertheyare.
Vulnerabilitywithoutempathycancomeacrossasfake.But whenleadersleadvulnerableandempathetic,theycreate cultureswherepeoplefeelseen,supported,andinspired.
Conclusion:LeadingwithHumanity,Leadingforthe Future
Asthecontemporaryworkplacebecomesincreasingly digital,dispersed,anddiverse,theneedforpeople-first leadershipisnotonlytimely;it'sessential.InanageofAI andalgorithms,thehumantouchofempathy,trust,and emotionalintelligencewilldistinguishgreatleadersfrom goodones.
Empathyisnotweakness.It'sstrength,allowingleadersto engage,enable,andleavelastingimpact.Impactis quantifiednotinthenumberofdecisionsmade,butinthe livesthosedecisionstouch.
Ultimately,people-firstleadershipismorethanconstructing performance—it'sconstructingpurpose,belonging,anda legacyofhumaninfluence.
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