The 10 Most Influential Primary Packaging Innovators Redefining the Industry in 2025 December2025

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December|Issue:577|2025

Reshaping Packaging

Packaging Innova on Leaders Redefining Sustainability

Smart Innova on

Smart Packaging Solu ons for a Greener Future

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Director Scien fic Affairs, Integrated Systems West Pharmaceu cal Services

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Strategic Leadership Shaping the Next Era of Packaging

P

rimary packaging is undergoing a profound transformation as brands, regulators, and consumers increasingly demand solutions that are smarter, safer, and more sustainable. The role of primary packaging now extends well beyond its traditional function of containment and protection. It has emerged as a strategic element that integrates innovation, regulatory compliance, environmental responsibility, and brand differentiation.

Industry leaders are responding to these evolving expectations by advancing recyclable, lightweight, and refill-friendly designs that reduce material usage and environmental impact without compromising functionality or quality. At the same time, they are moving beyond design-led changes to re-evaluate packaging life cycles in a holistic manner. This includes responsible raw material sourcing, efficient and optimised production processes, and the development of improved systems for collection, recycling, and end-of-life recovery.

CIOLook in its exclusive feature The 10 Most Influential Primary Packaging Innovators Redefining the Industry in 2025, recognizes individuals who are not only responding to ongoing shifts in the packaging landscape but are also actively shaping the future of the sector. These innovators are challenging conventional materials and processes while investing in advanced polymers, bio-based alternatives, smart packaging technologies, and precision manufacturing.

Their work reflects a strong understanding of evolving market requirements, including increasingly stringent

regulatory standards, higher sustainability benchmarks, and the growing importance of consumer trust. What sets these leaders apart is their ability to balance innovation with scalability. They are successfully translating research and development initiatives into commercially viable solutions, while working in close collaboration with brand owners, healthcare providers, and global supply chains to deliver meaningful impact at scale.

The evolution of primary packaging reflects a decisive shift toward a more responsible, innovative, and future-ready industry. As sustainability, compliance, and performance continue to redefine market expectations, the role of visionary leadership becomes increasingly critical. The leaders highlighted are driving meaningful change across materials, technologies, and processes, while maintaining a clear focus on scalability and real-world impact. Their contributions not only address current industry challenges but also lay the foundation for a more resilient and circular packaging ecosystem. Collectively, these innovators are setting new benchmarks for excellence and reinforcing the strategic importance of primary packaging in shaping the industry's long-term growth and sustainability.

Have a great read ahead!

Managing Editor

cont 08 Dr. Bettine Boltres Shaping the Future of Pharmaceutical Packaging Through Science, Collaboration, and Mentorship

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Smart Innovation Smart Packaging Solutions for a Greener Future

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Featuring

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Andrew Zimmermann Founder & CEO

West Pharmaceutical Dr. Bettine Boltres Director of Scientific Affairs, Services Integrated Systems westpharma.com

Dr. Bettine leads scientific strategy, research, and development initiatives focused on advancing drug delivery technologies and integrated healthcare systems.

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The 10 Most Influen al Primary Packaging Innovators Redefining the Industry in 2025

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career of scientific know-how and passion for leadership and industry development, Dr. Bettine Boltres is teaching upcoming scientists and is an author for a winning publication on pharmaceutical glass.

With a lifetime passion for health that has carried her from the lab bench to leadership that drove global pharmaceutical packaging regulation, she knows many times more than material science.

In her present role as Director of Scientific Affairs, Integrated Systems at West Pharmaceutical Services, she is shaping the next generation of professionals and driving packaging solution innovation. Her commitment to the convergence of research and practice is clearly seen in her life as writer, teacher, and business leader. Her mentorship guarantees that her legacy will be transmitted by empowering new voices and shaping their future.

From Lab Bench to Global Impact Dr. Boltres' path to pharmaceutical packaging leadership began with a fundamental passion for healthcare. "I have always been interested in everything around health care." she reflects, describing how this intrinsic motivation guided her career choices from the very beginning.

After completing her doctorate in biochemistry, she joined Schott's pharmaceutical business unit through their graduate program, a decision that later proved transformative. The comprehensive 1.5-year program took her through manufacturing plants across Germany, Switzerland, and the United States, providing her with an invaluable foundation in both glass materials science and global pharmaceutical operations.

"This experience was incredibly instructive. I am deeply thankful for this experience as it enriched my understanding of glass and the pharmaceutical sector." Dr. Boltres recalls.

During her seven years at Schott, she didn't just learn she taught, becoming a sought-after lecturer worldwide and

contributing to the FIOLAX® Academy, Schott's external education program.

It was during this period that she witnessed a pivotal industry transformation. "Pharmaceutical companies showed increasing interest in learning about the materials they are using based on more detailed inquiries from regulatory agencies." she explains. This shift from random component selection to science-driven material understanding inspired her to author a comprehensive book on glass applications in pharmaceuticals bridging the gap between overly technical glass literature and the brief packaging sections found in drug development texts.

The West Pharmaceutical Services Chapter After seven enriching years at Schott, Dr. Boltres felt ready to embrace new challenges, leading her to West Pharmaceutical Services. The transition allowed her to expand her expertise beyond glass materials, combining her deep glass knowledge with elastomer science to develop a more comprehensive understanding of pharmaceutical packaging systems.

"Moving to West, I further enhanced my understanding of the big picture and how all individual parts are synchronized within this big picture." she explains. This holistic perspective would become central to her approach to packaging science and her role in advancing industry standards.

In her current role as Director of Scientific Affairs, she is serving as a crucial bridge between West's innovative packaging solutions and the pharmaceutical industry's evolving needs. Her work goes far beyond traditional supplier relationships, focusing instead on fostering genuine scientific collaboration that advances the entire industry.

Championing Collaborative Innovation Central to Dr. Boltres' philosophy is the belief that meaningful progress requires industry-wide collaboration.

"I have always been convinced that the only way to move the industry forward is through collaboration," she states emphatically. This conviction led her to join the PDA in 2011, where she has become increasingly involved in shaping industry standards and practices.

Her contributions to PDA span multiple roles: from early involvement in the planning committee for the European Parenteral Packaging conference to serving as Interest

Group Lead, Task Force member writing Technical Reports, and providing training and presentations. In 2019, she joined the Board of Directors of PDA, further cementing her influence on industry direction.

"PDA is the ideal platform to facilitate exchange as they bring the entire industry together: component suppliers, pharmaceutical companies, machine vendors, regulators, consultants, and so on. You cannot evolve by yourself in your little chamber. You have to go out and see what the world is doing." she explains.

Her collaborative approach extends beyond formal industry associations. She is actively using her broad network throughout the industry to connect people and topics, fostering the kind of cross-pollination of ideas that drives innovation forward.

Addressing Industry Challenges Through Innovation One of the most significant challenges Dr. Boltres has encountered is facilitating knowledge exchange while respecting competitive boundaries. "You need to build some trust to exchange knowledge. You have to find a way to bring people together to discuss challenges and provide their insights without giving away confidential information." she explains.

This challenge is particularly acute when pharmaceutical companies work with multiple suppliers for the development of their container closure systems or combination products. The result is often "tedious 3-way CDAs, disaggregated information and misaligned coordination," she notes. Smaller companies often "do not know what they do not know," while larger multinational companies can become "chaotic within" due to their size and complexity.

These challenges had a direct influence on West's development of the West Synchrony™ Prefillable Syringe (PFS) System, a fully verified integrated solution that addresses many of these pain points. “It is a fully integrated and verified prefillable syringe system, it removes a lot of the complexity, insecurity and time-consuming efforts currently existing in the industry.” Dr. Boltres explains.

This innovation is representing a paradigm shift from component-driven approaches to system-based solutions, allowing pharmaceutical companies to skip complex multi-supplier coordination and move directly into drugdependent design verification testing.

Quality by Design: Speaking the Industry's Language Dr. Boltres' approach to developing high-value packaging solutions is deeply rooted in Quality by Design (QbD) principles. "If you want to develop something that is of value for the pharmaceutical industry, then you have to speak their language and think their way." she explains.

QbD's systematic approach beginning with predefined objectives and emphasizing product and process understanding based on sound science and quality risk management has been central to West's development philosophy. This approach was instrumental in creating the NovaPure® elastomer components portfolio and continues to guide the company's innovation strategy.

Looking ahead, Dr. Boltres is seeing an even greater need for this systematic approach as the industry grapples with the emergence of combination products and the convergence of pharmaceutical and medical device regulatory frameworks. "We are not just component suppliers anymore; we manufacture the device part of the combination product. This rethinking is going to shape the development, manufacturing and regulatory landscape on a global level over the next decades." she notes.

Shaping Industry Standards and Harmonization Dr. Boltres' influence extends well beyond West Pharmaceutical Services through her leadership roles in multiple industry organizations. As a member of the PDA Board of Directors, the USP Packaging & Distribution Expert Committee, European Pharmacopeia Working Groups, and ISO Technical Committee 76, she consistently striving to align and harmonize the industry to avoid timeconsuming redundancies.

Her contributions to industry guidance documents are particularly noteworthy. PDA Technical Reports such as TR-87 on glass handling have become essential references for the entire industry. When Notified Bodies became more heavily involved in assessing prefillable syringe safety and performance, creating uncertainty about submission requirements, she helped developing TR 73-2 on MDR GSPRs for PFS, including comprehensive guidance on documentation requirements.

"I am very confident that this report can save companies a lot of time and nerves." she reflects, demonstrating her practical focus on solving real-world industry challenges.

Leadership Philosophy and Mentorship For Dr. Boltres, leadership goes far beyond title or position.

"Leadership means having a vision and inspiring people with it. This naturally comes along with persistence and especially in our pharma world which is turning very slowly." she explains.

Her leadership philosophy acknowledges that meaningful change often requires difficult conversations and sustained effort. "Sometimes you need to go on the hard road and fight for your vision. People are not always ready for big new changes." she notes, citing sustainability initiatives as an example of necessary but challenging industry transformation.

Mentorship plays a crucial role in her leadership approach.

"Everything you build is going to collapse once you are gone if you don't have anyone continuing it." she emphasizes. When she identifies individuals eager to grow, she is actively promoting them into positions where they can develop their potential.

Her mentorship philosophy focuses on developing independent thinking rather than mere compliance.

According to her what is important for them to learn is not just to do things because they were told to do so, but because they think it is the right thing to do. That way they can develop their own vision and start working towards that.

Vision for the Future Dr. Boltres sees two major trends shaping pharmaceutical packaging's future. The first involves the precision medicine revolution enabled by advances in genomics and proteomics, supported by artificial intelligence. "We are going to be able to tailor treatments more to the patient and find out early on if they are responders or not.” she explains, noting that this approach will expand far beyond current applications like BRCA gene testing for breast cancer treatment.

The second trend involves a fundamental shift from reactive to proactive healthcare. "With a deeper understanding of the interactions between existing single nucleotid polymorphisms (SNPs) and learned lifestyle, we will be able to move from a reactive to a more proactive preventative way of dealing with our health and diseases."

Sustainability as a Personal Mission Perhaps most passionate among Dr. Boltres' future-focused

initiatives is her deep commitment to sustainability. "From a personal lens, I am most excited about the move towards a more sustainable way of living on this planet," she states with conviction. For her, this journey is not an abstract ideal but a necessary shift in how humanity understands its relationship with the world. "People need to realize that sustainability isn't just about saving a planet it's about preserving our own lives and those of future generations, since everything we do ultimately comes back to us," she emphasizes. she firmly believes that the healthcare industry can achieve ambitious sustainability goals without compromising patient safety. "I know that we as a healthcare industry are going to be able to combine a sustainable way of developing, manufacturing and recycling our healthcare products with continuing to put patient safety first. This is by no means a contradiction."

This conviction fuels much of her advocacy across industry organizations, where she consistently champions sustainable practices, forward-thinking innovation, and a collective responsibility to build a healthier future. for both people and the planet.

This vision drives much of her advocacy work across industry organizations, where she consistently promotes sustainable practices and thinking.

A Legacy of Scientific Excellence Dr. Bettine Boltres represents the best of what pharmaceutical packaging science can achieve: rigorous scientific thinking combined with collaborative leadership and a clear vision for industry advancement. Her career demonstrates that meaningful progress comes not from working in isolation, but from building bridges between organizations, disciplines, and ways of thinking.

As the pharmaceutical industry continues to evolve, with new therapeutic modalities, changing regulatory landscapes, and growing sustainability imperatives leaders like Dr. Boltres will be essential in navigating these challenges while maintaining the scientific rigor that ensures patient safety and therapeutic efficacy.

In an industry where the stakes couldn't be higher where packaging failures can mean the difference between therapeutic success and patient harm her commitment to excellence, collaboration, and continuous improvement ensures that pharmaceutical packaging science will continue to advance in service of better patient outcomes worldwide.

Reshaping Packaging

PACKAGING INNOVATION

LEADERS REDEFINING

SUSTAINABILITY

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sustainability. The packaging industry has traditionally relied on materials like plastic, which, while cost-effective and versatile, contribute significantly to global pollution.

Today, companies at the forefront of innovation are exploring alternatives that reduce carbon footprints, encourage circularity, and minimize waste.

ustainability has become a central concern for industries across the globe, and the packaging sector is no exception. As consumer awareness about environmental impact grows, companies are increasingly pressured to adopt eco-friendly packaging solutions.

Leading brands and innovators are now redefining the standards for sustainable packaging, leveraging technology, materials science, and design thinking to balance environmental responsibility with functional and aesthetic appeal. The shift is not only driven by regulatory mandates but also by the rising expectation among consumers for brands to demonstrate tangible commitments to

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Pioneering Material Innovations Material innovation is at the heart of sustainable packaging transformation. Companies are investing in research to develop bio-based plastics, compostable films, and plant-

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derived materials that offer durability without the environmental cost of conventional plastics. For instance, firms are experimenting with materials such as polylactic acid, derived from corn starch, and mushroom-based packaging, which can naturally decompose after use. These solutions not only reduce dependency on fossil fuels but also provide new opportunities for product differentiation in a market increasingly conscious of sustainability.

Collaborative and Circular Approaches Collaboration across industries is a key driver of sustainable packaging solutions. No single company can address the environmental challenges of packaging alone, and leaders are forming partnerships with suppliers, recyclers, and startups to accelerate change. Industry consortia focus on developing standards, sharing research, and creating infrastructure to support recyclable and compostable materials at scale. By working together, companies can reduce costs, improve supply chain efficiency, and ensure that sustainable packaging innovations are commercially viable.

Beyond biodegradable options, innovation extends to enhancing recyclability. Leaders in the field are designing packaging that is easy to disassemble and sort, ensuring that end-of-life recovery is streamlined. Efforts include monomaterial packaging, where a single type of material is used, making recycling more efficient. Such innovations are supported by rigorous lifecycle assessments, allowing companies to measure environmental impact at every stage of production and adjust designs to optimize sustainability outcomes. Material innovation, therefore, represents both a technological and strategic advantage for brands aiming to resonate with environmentally conscious consumers.

Circularity is also a central principle guiding these efforts.

Packaging leaders are designing systems where materials are continuously reused or reintegrated into production cycles. Refillable packaging, closed-loop recycling programs, and material take-back schemes exemplify the circular approach. These models reduce the need for virgin materials, limit waste, and create long-term environmental benefits. By embedding circularity into their strategies, companies demonstrate that sustainability can coexist with profitability, providing a blueprint for the broader industry to follow.

Technology-Driven Efficiency Sustainability in packaging is also being driven by technological advancements that optimize production and reduce waste. Digital printing and precision cutting techniques allow for customization and reduced material use, while smart packaging solutions track product lifecycle and encourage responsible disposal. Automation in packaging lines minimizes errors and material loss, and data analytics help companies predict demand more accurately, reducing overproduction and excess packaging.

These technologies are transforming packaging from a passive product container into an active component of a brand's sustainability strategy.

Conclusion The packaging sector is undergoing a profound transformation as innovation leaders redefine what it means to be sustainable. Through material advancements, technology-driven efficiency, and collaborative circular approaches, companies are addressing the environmental challenges of packaging while creating value for consumers and stakeholders. Sustainability is no longer an optional feature but a fundamental expectation that shapes brand identity and market competitiveness. As consumer awareness and regulatory pressures continue to rise, the momentum behind sustainable packaging is set to accelerate. Businesses that embrace innovation, invest in sustainable materials, and integrate circular principles into their strategies will not only mitigate environmental impact but also position themselves as industry leaders.

Additionally, technology enables the development of packaging that interacts with consumers to promote environmental responsibility. QR codes and augmented reality features on packaging can educate users about recycling, composting, or returning programs, fostering a culture of conscious consumption. Some companies are implementing returnable packaging systems where consumers send back containers for reuse, leveraging digital platforms to incentivize participation. By combining innovation in materials with digital technologies, packaging leaders are creating solutions that are not only environmentally responsible but also engage consumers in meaningful ways.

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Smart Innovation

SMART PACKAGING SOLUTIONS FOR A

GREENER FUTURE

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he packaging sector is going through a radical change as sustainability is becoming a key concern for governments, businesses, and consumers. The traditional packaging, which is usually based on single, use plastics and resource, intensive materials, has been criticized for its contribution to the environmental degradation. Thus, innovations in materials science, digital technologies, and supply chain management are enabling the rise of intelligent packaging solutions aimed at cutting waste, increasing efficiency, and facilitating a circular economy. The employment of state, of, the, art materials, data, enabling technologies, and eco, friendly design principles to enhance product life cycles while lessening environmental impact is what differentiates smart

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packaging solutions from the basic features of product protections. On the one hand, smart packaging has the potentials of limiting food waste, making products more recyclable, and allowing for a better tracking of the supply chains on the other hand. Hence, it is progressively being acknowledged as a vital factor in the realization of a clean future.

Sustainable Smart Packaging At the heart of Smart packaging solutions is a wish to minimize environmental impact right through the packaging value chain. It starts with material selection. Biodegradable polymers, recyclable mono materials, and compostable

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alternatives are replacing traditional plastics in many uses.

Companies can slash carbon emissions and resource use by up to 100% or more simply by designing packaging to use fewer raw materials yet perform just as well. Smart packaging solutions also enhance sustainability by extending shelf life and reducing waste. Active packaging technologies-which include oxygen absorbers, moisture regulators, and antimicrobial coatings-help extend the life of foods and pharmaceuticals.

packaging designs also include the above elements with the most up-to-date enhancement in smart technology.

Temperature-sensitive indicators, for instance, would notify parties if the packed items have not been stored in appropriate conditions, thus eliminating the need for disposal.

Future of Smart Packaging The use of smart packaging solutions is also altering the way consumers behave and think. Consumers in the modern era are more conscious about the environment and are demanding more transparency from brands. With smart packaging solutions, it becomes easy for brands to showcase their sustainable practices to consumers using digital interfaces. As far as the industry is concerned, smart packaging solutions can ensure that companies follow the increasing need to focus on sustainable practices by governments, which are bringing in tougher regulations on packaging waste, recyclability, and carbon emissions in different countries across the globe.

This is highly relevant to food waste, one of the largest contributors to greenhouse gas emissions globally. By maintaining products safe and usable for longer, smart packaging directly contributes to environmental and economic sustainability. The other critical front is increased recyclability and better waste management. Smart packaging technologies have such features like labeling, watermarks, or barcodes that provide instructions on disposal. This assists in improving the volume rate of recyclables, as well as reducing contamination. Such technologies are becoming increasingly imperative for the perfect execution of the circular approach within the vast recycling infrastructure models within the world. The approach ensures the complete loop for packaging.

The adoption of smart packaging solutions will enable organizations to remain one step ahead of regulations, while simultaneously strengthening their sustainability offerings.

In fact, this will not only help organizations mitigate risks, but organizations will also be able to improve brand reputation and resilience. In the future, companies along the value chain will need to collaborate in order to fully enjoy the benefits of smart packaging solutions. This will include organizations such as packaging organizations, technology organizations, brand organizations, and organizations that manage waste. With the continued development of such collaborations, smart packaging solutions will play a pivotal role in cultivating a greener economy.

Innovation in Smart Packaging Among the factors that have contributed to the significant growth in the adoption of smart packaging solutions is technological development. Digital technology, including QR code, near field communication, and Radio frequency identification, allows for real-time tracking and data entry in the supply chain. Smart packaging solutions will also create efficiency in forecasting and managing inventories.

Accurate data on product tracking will also help in limiting product overproduction and the development of unnecessary inventories in businesses, thus increasing efficiency in logistics operations and decreasing the consumption and emissions of fuel in businesses.

Conclusion Smart packaging solutions are presently making their entry as an important solution in the shift towards forming a sustainable production and consumption pattern. By making adept use of innovative materials and smart technologies along with smart designs, the impact on the environment can be optimized and efficiency optimized in the entire chain. As sustainability has become a consideration not only for businesses, but also for people, subsequent innovation in smart packaging can play an important role in affecting changes in waste management and resource conservation. In other words, smart packaging has immense potential to form an important corner of the sustainable future.

This serves the double purpose of reducing costs and preventing wastage of products which are unsold or have expired. Additionally, such products are replaced to meet the customer demand. In the food, beverage, and healthcare industries, such optimizations directly result in sustainable benefits to the planet. Material technology is another area where significant advancements have occurred. Ecofriendly packaging designs with the incorporation of biomaterials, edible packaging, and re-usable packaging are on the verge of changing the possibilities and prospects with regard to biodegradable packaging designs. By now, smart

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