Innovation Express Magazine Vol 1 Issue 3

Vol 1 Issue 3 July 2022

AHIS22 EXCLUSIVE A speci al sneak peak i nto thi s year' s AHI S i nnovati ve i nteracti ve exhi bi ts

DEEP MEDICINE How arti fi ci al i ntel l i gence can make heal thcare human agai n

VENJA HEALTH Recognizing and addressing loneliness as a prevalent healthcare need.

INNOVATION EXPRESS MAGAZINE

TABLE OF CONTENTS AHIS22

03 Editor's Note 04

A special sneak peak into this year's AHIS innovative interactive exhibits

09 Deep Medicine: How artificial intelligence can make healthcare human again 13 Precision Medicine – Healthcare’s promising disrupter?

18 AHIS Call for abstracts 19 Blogwatch 23 Effectively Communicating with Innovators 28 Venja Health: Recognizing and addressing loneliness as a prevalent healthcare need.

33 Under The Scope: Events that need tto be on your calendar 34 Xavier's Center for Innovation

173 E MCMILLAN STREET CINCINNATI, OH 45219, USA INFO@INNOVATIONEXPRESS.ORG

INNOVATIONEXPRESS.ORG

A NOTE FROM

OUR EDITOR The first thing I was taught in the Biomedical Writing Master’s program was “first, know your audience”. It came up time and again, because if you do not know to whom you are trying to communicate information, how can you be an effective communicator?

Our audience is you! You come from all walks of life, all over the world, and from many different cultural backgrounds. You might hold a degree in healthcare or engineering, or not; you might be 16 or 60, a potential investor, or an avid learner. We can all be innovators, disrupters, and influencers.

In this issue, I have an article discussing effective communication to innovators; it’s not as simple as it sounds, I have found. We also feature a book review on Deep Learning and its application to healthcare by a talented scientist who had an abstract at Advancing Healthcare Innovation Summit 2021.

BlogWatch author Maria Ashton has found for us some very compelling content to browse through; you might find yourself in a wormhole of entertainment. In addition, we have an up-to-the minute overview of precision medicine and where the future lies by Nina Flanagan.

As always, don’t forget to register (free) for AHIS2022! I’d love to see you there. This issue contains information about the vendors, exhibits and presentations you can expect to see, and the workshops we will be running.

I would really like to get to know you, our audience, better!

If you’d like to comment on the issue, or ask about contributing to IE, drop me an email at InnovationExpresseditor@gmail.com, or connect with me and Innovation Express on LinkedIn

Gail Pyne-Geithman innovationexpress.org

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AHIS2022 is the second annual major healthcare conference and exhibit showcasing the latest innovations related to healthcare and medical sciences. AHIS2022 is a networking conference for all stakeholders in healthcare innovations. The Summit provides a platform for participants to share experiences and knowledge about best practices of promoting innovations in healthcare.

It promotes innovators and researchers to share their ideas, findings, results of their latest innovative projects and interact with experts of all disciplines.

Join us as we collaborate to bring monumental changes and make our region a global hub for healthcare innovation.

Cincinnati is a hub of innovation. We plan to be the showcase of healthcare related innovation and share it globally. AHIS will be an international event soon- Ashley H.

Register for free at www.ahisummits.com

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Announcing: CTI will be hosting the Research, AI & Informatics Breakout Room!

Click Image for larger view of agenda innovationexpress.org

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1

The Innovation Theater presented by Innovation Express Magazine provides an opportunity to highlight innovative ideas, projects or products by innovative companies or individuals.

2

Objectives: 1. Learning innovative approaches to improve health and to decrease disparities in healthcare 2. Educating innovators and offering opportunities to showcase work, network, etc.

3. Highlighting the latest innovative projects, products and developments in healthcare.

3

Abstract Presentations: We are excited about the accepted abstracts. Topics range from AI to devices and after presentations their will be a cash prize award!

4

Career Center will have recruiters from all over available to discuss career options in healthcare.

In order to grow we must work together to highlight innovation at its finest

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NOVEMBER 11, 2022

HYATT REGENCY DOWNTOWN CINCINNATI Our Scientific Committee is a group of visionary innovators that are dedicated to the success of AHIS2022.

Abdul Rahman Jazieh MD, MPH- Founder of Innovative Healthcare Institute Timothy Schroeder- CEO of CTI ( The #1 CRO in the world) William L. Barret MD- CEO/Founder of Cincinnati Cancer Advisors Thomas Herzog MD- Deputy Director of the University of Cincinnati Cancer Center Zisis Kozlakidis MD, Head of Innovation & Research for World Health Organization (WHO)

BREAKOUT ROOMS These rooms will be discipline focused and geared to attract specific attendees that can learn from the innovative components in each room. There will be a special presentation hosted by each room at various points of the day.

Precision & Regenerative Health Room Surgery & Interventional Medicine Room Devices, Tools & Wearables Room AI, Informatics and Research Room

REGISTER FOR FREE The greatest part of AHIS is that it is free to attend. To learn more and to register at no cost visit www.ahisummits.com

Save the Date

MARCH 11, 2023 SECOND ANNUAL

PRECISION ONCOLOGY FORUM CLOSING THE GAP BETWEEN KNOWLEDGE AND PRACTICE

www.innovativehci.com

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Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again "Can AUTHOR: ERIC TOPOL EDITION: FIRST YEAR: 2019 PUBLISHER: BASIC BOOKS, NEW YORK ISBN 9781541644632

medicine be more human because of AI?" The

rapid

proliferation

of

Artificial

Intelligence (AI) tools in healthcare is approaching a point in time where it is imperative for health care professionals and the general population to recognize the numerous ways in which data driven AI tools are poised to impact the practice of medicine and the way care is delivered.

While the media coverage and most Reviewed by Elan Somasundaram, PhD. Faculty in the Imaging Research Center and AI Core at Cincinnati Children’s Hospital Medical Center. See his research and publications here.

academic literature paint a rosy picture on the uncanny abilities of AI in healthcare and how they would transform medicine, the reality is more nuanced and requires extensive discussion, education, planning

and rethinking of priorities such that this new era of AI augmented medicine is truly transformational and equitable to everyone involved in healthcare. Deep Medicine by Eric Topol is a comprehensive work that lays down the premise of AI in healthcare, how it could solve current challenges in medicine, and provides a list of desirable outcomes that should drive the design and adoption of AI systems in the clinic. The author presents his viewpoints substantiated with extensive literature survey and anecdotes derived from his long experience as a cardiologist, as a consultant for various AI initiatives, and from his encounters with the healthcare system as a patient.

pg 9

Deep Medicine has 13 well-defined chapters.

Chapter 4 and 5 are dedicated to

The

the subcategory of AI algorithms

first

3

chapters

delve

fundamental challenges faced

into

the

by modern

known as deep learning. Skinny on

recent

Deep Learning is a complete primer

achievements in the field of AI using

on the class of models that are the

Machine

backbone of many recent AI tools

medicine

and

highlight

Learning

and

the Deep

Learning

algorithms. Introduction to Deep Medicine

that have demonstrated

explains the complexities in making a correct

performance exceeding humans in

disease

various challenging tasks including

diagnosis

through

real-world

scenarios, especially given the large body of

image classification and natural

digital medical literature available today. It

language processing, two tasks that

also provides insights into the tasks that

have numerous applications in

could benefit by harnessing the power of AI

healthcare. The evolution of neural

and how such tools could be crucial in

networks, their basic architecture,

enabling healthcare providers focus their

types of learning strategies and

attention on the patient’s well-being, both

definitions for related terminologies

physical and emotional.

are presented in simple terms.

In chapter 2, Shallow Medicine, the author

In Deep Liabilities, the focus is on the limitations, concerns, and compromises in adopting sophisticated AI tools, such as those powered by deep neural networks into the clinical workflow. The author makes a very important distinction that AI algorithms of today are only good at specific tasks, and they still lack the ability to seamlessly process contextual information. Issues related to availability of high-quality medical datasets, propagation of society’s inherent biases and inequities into training data leading to compromised AI models, protection of sensitive information and interpretability concerns due to the black-box nature of AI models are described in detail.

argues in detail the perils of some of the seemingly advanced technological adoptions in modern medicine such as the electronic health records system and the slew of diagnostic examinations that are at the physician’s disposal. The alarming numbers of reported misdiagnoses, unnecessary tests and imaging exams ordered give a wake-up call for active community participation in designing AI based healthcare tools such that they are efficient and effective in delivering their promise of improved quality of care. Medical diagnosis, the third chapter starts with a deep dive into the underlying principles of differential diagnosis as taught

In

chapters

6-8,

in-depth

discussion on the role of AI in various subspecialties of medicine are presented. AI in medical imaging has grown into its own field with Convolutional

Neural

Network

architectures such as the U-net showcasing

state-of-the-art

performance on numerous tasks such as pneumonia detection in radiographs, organ delineation in 3dimensional cross-sectional images and

cancer

detection

from

pathology slides.

Hence, in Doctors and Patterns, the achievements

of

AI

in

various

imaging applications, especially in radiology

and

pathology

are

presented along with insights into how the physician’s job in these subspecialties would change with AI assisted workflows.

in medical schools. The author contends that System 1 thinking which leads to quick, intuitive diagnosis might not be the optimal strategy to train physicians for an era of personalized medicine and big data. This chapter also provides insights into the sources of uncertainties and biases in today’s medical diagnosis backed by relevant studies and statistics.

INNOVATION EXPRESS MAGAZINE

an

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being pursued are presented in AI and Health Systems. Chapters 10

designing such sophisticated AI

and 11 focus on areas that are

assistants. The final chapter, Deep

auxiliary to healthcare that are

Empathy, is a roundup of how the

In Clinicians Without Patterns, all

beginning to be redefined using AI

doctor-patient relationship has

subspecialities that do not benefit

techniques. Deep Discovery covers

evolved over time and how the

directly from the superior pattern

topics such as drug discovery,

focus of any advanced AI adoption

recognition abilities of AI

neuroscience, scientific research

should be to strengthen this

algorithms but rely more on their

for disease identification and

relationship which is vital to

ability to make predictions by

understanding, while Deep Diet

improve the experience for the

embedding vast amount of

focuses on various inroads made

patients, physicians, care givers

information from multimodal

by data science towards

and families.

datasets are discussed.

personalized nutrition.

Overall, this book provides “deep”

Applications in this category span

insights into some of the pitfalls of

a broad spectrum ranging from

The Virtual Medical Assistant is an

current medical practice through

accelerated image reconstruction,

interesting chapter that puts forth

real-world examples that are

speech-to-text translation for

the author’s vision on how the AI

relatable to most people that have

notes taking, summarization of

tools developed across multiple

interacted with the American

patient status from electronic

disciplines will culminate in an

healthcare system. The latest

health records and rare disease

optimal assistant for managing

boom in AI capabilities has given a

detection. In Mental Health, a

one’s health and lifestyle.

lot of hope to address many of the

detailed account of AI applications

This chapter also brings to light the

limitations in healthcare and this

for pre-screening, diagnosis,

ownership and governance issues

book does a good job of

phenotyping, and monitoring of

in managing personalized health

summarizing them from a neutral

patients with neural disorders

data and behavioral challenges

standpoint. While some of the AI

using traditional clinical

that need to be addressed before

case studies and applications cited

approaches such as speech and

in this book might already be

visual tests as well as innovative

outdated due to the rapid progress

approaches based on digital data acquired from personal devices is discussed.

AI is also destined to have a major impact on healthcare systems such as enterprise software, patient management tools, workflow management, and insurance and billing platforms. An overview of the current state of such systems,

"This book is a in this field, this book is a treasure a lot of valuable information treasure with a with for physicians, researchers, lot of valuable hospital administrators and the general audience. information for physicians, researchers, hospital administrators and the general audience."

their inefficiencies and AI based solutions that are

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PRECISION MEDICINE – HEALTHCARE’S PROMISING DISRUPTER?

By Nina Flanagan

P

recision medicine has the potential to revolutionize healthcare by providing better treatment options and earlier diagnoses. The inclusion of genetic, lifestyle, and environmental information serves as a roadmap to personalized care. Genetic information and analysis create massive amounts of data that ideally leads to new drug targets and better understanding of disease processes. Along the way, new initiatives and innovations are being developed to address health disparities and to advance research efforts.

The frequency of “Precision Medicine” as a title phrase over time in the medical literature gives a striking visual of the explosion of interest in this innovative approach.

A shift from a “one-size-fits-all” treatment approach to precision medicine has huge implications for healthcare. A 2021 Research & Markets report estimated the global precision medicine market will reach $100 USD billion by 2026, driven by a surge in chronic diseases, such as cancer, cardiovascular disease, and obesity. Cancer alone is expected to increase 47% worldwide by 2040, affecting 28.4 million people.

Cardiovascular diseases remain the leading cause of death worldwide, costing almost 18 million lives every year. These public health challenges are incentives to adapt precision medicine and there are now 14 countries with national genomic initiatives.

Addressing Health Disparities Using Precision Medicine Approaches

There are concerns that the potential of precision medicine remains overshadowed by health disparities.

Several initiatives are currently addressing this.

The All of Us Research Program, established in 2015 by former President Obama in collaboration with the National Institutes of Health (NIH), is working to address health disparities by reaching out to all communities to enlist one million volunteers for its DNA registry.

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The program recently involved tribal leaders of the American Indian and American Alaskan populations for inclusion in this registry. Its first genomic data set was released in March, including 100,000 whole genome sequences and 165,000 genotyping arrays with almost half the data from those who selfidentified as a racial or ethnic minority group.

Additional programs include drug developers partnering with health systems which have large databases of genomic information. For example, Regeneron Pharmaceuticals, Inc., has partnered with Geisinger’s Health System in Pennsylvania to obtain 250,00 DNA samples from volunteers to be used for identifying and validating new drug targets and pharmacogenetic markers.

Regeneron announced last year that they discovered a rare genetic variation on a gene, GPR75, that reduces the risk of obesity by 54% and is developing potential therapeutics. The discovery process included a large study that analyzed genetic and health data from almost 650,000 volunteers in collaboration with Geisinger and three additional health organizations. This has far-reaching implications since it’s estimated that there will be a billion people worldwide with obesity by 2030.

Current Key Innovations Shaping Healthcare

Large databases of genomic information require fast analysis and data tracking. Innovations in artificial intelligence (AI) and machine learning continue to be developed to address these needs.

However, AI and machine learning are also being used to predict disease. Researchers at Cincinnati Children’s Hospital are using these tools to help identify children at high risk of developing a mental health condition (depression, anxiety, and suicide) over time, potentially resulting in better outcomes and quality of life.

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Under the umbrella of drug development, key technologies include the identity and validation of biomarkers to monitor drug responses and the development of new biomarkers with enhanced specificity for safer medications. One of the latest cell therapies, CAR-T (Chimeric Antigen Receptors T cells) treatment has been shown to be successful for hard-to-treat blood cancers like leukemia and lymphoma but has shown limited success for solid tumors.

Researchers are adapting messenger RNA (mRNA) technology, recently made use of in COVID-19 vaccines, for personalized cancer vaccines. The MD Anderson Cancer Center has a Phase II clinical trial using mRNA to prevent recurrent colorectal cancer. There are additional trials at other institutions using this technology to potentially treat melanoma (advanced skin cancer), lung, and breast cancer.

Pharmacogenomics is providing testing for gene variations that leads to better treatment options. As of last year, there were 178 new drug approvals to date with labeled pharmacogenomic biomarker information, with oncology as the most common therapeutic area (49.4%). Additional therapeutic areas include neurology, infectious disease, psychiatry, metabolism, cardiology, hematology, and pulmonology. These are prescribed based on an individual’s genetics.

Challenges Moving Ahead Various health data – genetic, real-time data from wearables and other personal monitoring devices, clinical, and environmental, will create a unique, complete individual profile that will, ideally, provide better treatment options. However, challenges still exist. Manufacturing will need to scale-up via automation and agile software to meet the potential demand for new, customized therapies. Cybersecurity and privacy issues relating to the collection, storage, and access of data remain ongoing concerns for stakeholders.

Accessibility to new treatments is often hampered by insurance guidelines. A group of healthcare and patient advocacy groups addressed their concerns in a letter to Congress last year regarding access to targeted autoimmune disease therapies. The group stated that these diseases “have a disproportionate impact on women – nearly three-quarters – and are more common in minority populations.” Furthermore, they said these diseases often go undiagnosed until symptoms appear in advanced stages. Many insurers, including Medicare Advantage, use “step therapy” that requires patients to try drugs on the plans’ formulary to see what works and what fails. However, drug substitutions become more difficult with customized products. The group urged Congress to provide access to predictive drug response testing to help streamline effective treatment decisions.

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IN SHORT There’s no doubt that precision medicine will continue to evolve and provide more diagnostic tools and therapies as it expands into other therapeutic areas besides cancer, such as cardiovascular, metabolic, and neurodegenerative diseases. According to the Personalized Medicine Coalition, more than 30% of FDA new drug approvals in 4 of the 5 years between 2016 and 2021 were personalized medicines, with 17 approved last year. The agency also approved new indications for nine diagnostic tests to help assess targeted therapy decisions.

There may be a day in the future when a wearable device can quickly scan your DNA to pinpoint potential disease markers or mutations well before any symptoms appear. Perhaps nanoparticles will repair those mutations or prevent autoimmune responses. Armed with the right technology, you may be able to diagnose and heal yourself using your own cells. Sounds like science fiction?

Maybe – but it took 13 years initially to sequence the human genome and now it can be done in a day or two. Precision medicine has the potential to advance healthcare for all populations. It will be interesting to see what new technologies develop over the next five years.

References Doxzen, Kevin, et.al. 2022. “Advancing Precision Medicine through Agile Governance. Bridging innovation and regulation for the greater good.” Accessed May 22, 2022. https://www.brookings.edu/research/advancing-precision-medicine-through Kelly, T. et al. 2008. Global burden of obesity in 2005 and projections to 2030. Accessed June 3, 2022. https://pubmed.ncbi.nlm.nih.gov/18607383/#:~:text=By%202030%2C%20the%20respective%20number,and%201.12%20billion%20obese%20individuals MD Anderson Cancer Center. 2021. “Can mRNA vaccines be used in cancer care?” Accessed May 23, 2022. https://www.mdanderson.org/cancerwise/canmrna-vaccines-like-those-used-for-covid-19-be-used-in-cancer-care.h00-159457689.html NIH. 2022. “Research Roundup: Genomic data release opens new paths for discovery.” Accessed May 23, 2022. https://www.allofus.nih.gov/news-events/announcements/research-roundup-genomic-data-release-opens-new-paths-discovery Personalized Medicine Coalition. 2021. “Personalized Medicine at the FDA: The Scope & Significance of Progress in 2021.” Accessed May 26, 2002. https://www.personalizedmedicinecoalition.org/Userfiles/PMCCorporate/file/Personalized_Medicine_at_FDA_The_Scope_Significance_of_Progress_in_2021.pdf Regeneron. n.d. “About the Regeneron Genetics Center and the Geisinger Health System Collaboration.” Accessed May 22, 2022. https://www.regeneron.com/downloads/rgc_factsheet_ghscollaboration_final.pdf Research and Markets. 2021. “The Worldwide Precision Medicine Market is Expected to Reach $100 Billion by 2026.” Cision. Accessed May 25, 2022. https://www.prnewswire.com/news-releases/the-worldwide-precision-medicine-industry-is-expected-to-reach-100-billion-by-2026-301221065.html

The editors. 2021. RealClear Health. “Emerging Innovations Within the Field of Precision Medicine. Accessed May 26, 2022. https://www.realclearhealth.com/articles/2021/11/13/emerging_innovations_within_the_field_of_precision_medicine_111266.html World Health Organization. 2021. “Cardiovascular Diseases.” Accessed May 24, 2022. https://www.who.int/health-topics/cardiovascular-diseases

There is a way to do it better -Find it!

THOMAS A. EDISON

2022 THE AIMS OF AHIS2022 ARE: To provide a platform for stakeholders in healthcare innovation to network, exchange knowledge and ideas, and collaborate to bring monumental changes that improve access to quality healthcare and reduce disparities.

NOVEMBER 11TH, TWENTYTWENTYTWO HYATT REGENCY CINCINNATI,OH

Call For Abstract Submissions TOPICS INCLUDE Artificial intelligence Communication Digital health Healthcare economics Innovation in diagnostics Innovation in drug / therapeutics development Innovation in healthcare delivery models Innovation in imaging and radiology Innovation in intervention and surgery Innovation in research Innovations to address disparities in healthcare Personalized medicine and biomarkers Telehealth Virtual reality

Opens on December 15, 2021

Closes on Sept 15th, 2022 Decision Letter sent by October 1, 2022 FOR QUESTIONS RELATED TO ABSTRACTS PLEASE EMAIL

Events@innovativehci.com

There will be (1) Travel Award granted to the best abstract submitted by a student or a trainee to defray the cost of travel expenses to attend the meeting in person.

This award will be announced on June 30th.

We have scoured the vast repository of knowledge that is “the internet” to bring you a select few blogs, vlogs, podcasts and channels that deliver quality content in the areas of healthcare disparities and healthcare innovations.

THE MEDICAL FUTURIST Dr. Bertalan Mesko, MD, PhD, is The Medical Futurist and the Director of The Medical Futurist Institute analyzing how science fiction technologies can become a reality in medicine and healthcare.

He has presented courses at Harvard, Stanford and Yale Universities, and for the 10 biggest pharmaceutical companies. Huffington Post named Dr Mesko one of the 30 biotech thinkers with the biggest global impact.

IE BLOG WATCH

A ROUNDUP OF THE BLOGS, PODCASTS AND YOUTUBE CHANNELS WORTH YOUR TIME Maria Ashton, M.S., R.Ph., M.B.A.

His YouTube channel contains videos on the future of medicine, healthcare, diseases, treatments and technologies shaping the coming years. He also talks about how technology can disrupt current healthcare and provide more equitable access to care.

His fascinating and entertaining vlogs that show real technologies include May 10, 2022 “10- Super-Creepy Medical Technologies” Click To Watch March 22, 2022 “The Metaverse Could Transform Healthcare “ Click To Watch Another vlog that will enthrall my fellow trekkies, February 15, 2019 “Will the Medical Tricorder from Star Trek Become Real?"

Click To Watch His more serious videos include his December 16, 2022 Top 5 Medical Innovations in 2022 - AI in diagnosis, voice biomarkers, chatbots in healthcare, at home lab tests and digital health insurance.

Click To Watch

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The Organisation for Economic Cooperation and Development (OECD) Library Podcasts The OECD is an international organization of 37 member counties that serves as a hub for data, analysis, experiences, best-practices and advice on public policies and international standardsetting. Over their sixty-year history, they have developed more than 450 international standards, evidence-based policy analysis and recommendations, and global policy networks.

OECD’s 15-minute podcasts – the Technofile, OECD Education, and A Better Tomorrow - include interviews with OECD members and guest experts on topics such as inequality and inclusive growth, digital transformation, social change, the environment and international co-operation.

In 2022, the Technofile is presenting a series of podcasts on

INNOVATION EXPRESS BLOG WATCH

Artificial Intelligence (AI). Robin Allison Davis, an EMMY award-winning documentary producer and content creator, hosts the first podcast, “AI is poised to revolutionize healthcare. Building trust is the key” with guests Lina Gálvez Muñoz PhD, European Parliament Member – Spain, Vice Chair of the Committee on Industry, Research and Energy, member of the European Parliament’s Panel for the Future of Science and Technology (STOA) and of the OECD Parliamentary Group on AI; and Karim Lekadir, PhD, head of EUCanImage (@EuCanImage), a 4-year international multicenter project to build a highly secure, federated, large-scale European cancer imaging platform.

Click us

A Healthier Future Healthcare transformation leader Marc Harrison MD, president and CEO of Intermountain Healthcare, hosts A Healthier Future -- a weekly 30–40-minute podcast of conversations with other leaders discussing ideas for healthcare systems improvement. Topics include, boosting clinical efficiency through innovation, helping people age better, healthcare equity, increasing access to affordable care, and using AI to improve quality of life.

On March 14, Dr Harrison spoke to Anne Wojcicki, the CEO of 23andme. 23andMe offers home DNA kits to help people understand their ancestry and learn what their genetics say about their health. Anne’s vision is the democratization of healthcare, personalized healthcare delivered affordably and accessibly.

Anne and Marc discuss how her company built a database big enough to identify new links between diseases and particular

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genes. This research is fueling creation of drugs that can be tailored to different genetic profiles. Anne also discussed 23andMe’s acquisition of Lemonaid Health “This acquisition will help our customers access care from providers that are trained to incorporate genetic data into care.”

Click me

Healthcare weekly: at the forefront of healthcare innovation Healthcare Weekly is a digital magazine and peer-supported community for C-suite executives in the healthcare industry.

Healthcare Weekly’s collection of 51 podcasts discuss how technology is reshaping the healthcare industry and healthcare delivery. The hosts, Codrin Arsene and Michael Reddy of Digital Authority Partners interview healthcare innovators to look at how innovations, such as blockchain, artificial intelligence, virtual reality and big data can be leveraged to improve patient outcomes.

Tracy Warren cofounder and CEO of Astarte Medical, a precision nutrition company focused on feeding, nutrition and in children from conception to age 2, with a special focus on preterm infants. Based on a large dataset of preterm infant microbiome profiles and corresponding clinical data, their digital platform uses machine learning to automate feeding profiles, provide quantification of preterm infant gut health for benchmarking and personalized care through risk stratification.

Would you like your blog or podcast featured in our next issue?

We are always looking forward to highlighting new creators. Please submit your links and publications to info@innovationexpress.org and we will let you know if your submission has been chosen for publication. Please contact us for questions, comments, or marketing opportunities.

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At Genoa we specialize in mental health and substance abuse disorders. Our mission is to deliver outstanding care to all consumers living with mental illness and substance abuse disorders through a higher level of pharmacy care.

Contact London Shahid-Dawson, Consumer Medication Coordinator for all your personalized medication needs

(513) 761-6222 ext1750 LDawson@genoahealthcare.com

Effectively Communicating with Innovators

Innovation depends on clear communication of ideas among stakeholders and innovators.

By Gail Pyne-Geithman, MS, D.Phil.

The first thing I learned from my biomedical writing mentors is “who is your audience?”

Innovators can come from anywhere, any age, any education level, or specialty.

When it comes to academic scientific reporting, the audience is, typically, similarly qualified scientists and healthcare practitioners, or “peers”. Often, though, these publications include information crucial to innovators such as identification of critical clinical needs, or proposals for solutions to certain roadblocks in healthcare innovation.

So how can we make this information more accessible to a non-academic innovator audience?

In the cycle of bringing a medical innovation to practice, there are a number of players, all of whom must communicate effectively with each other.

CAN THERE BE A BROADER AUDIENCE THAN “THE PUBLIC”?

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The Federal Government has made some efforts to make sure their communications to the public are appropriate in terms of language and literacy level. The Plain Writing Act of 2010 (H.R. 946/Public Law 111-274) seeks to ensure that all communications between the Federal government and the public is at a level that can be easily understood. This is generally considered to be at a 6th-grade reading level. The NIH provide guidance for writers wishing to communicate clearly to their specific audiences https://www.nih.gov/institutes-nih/nih-office-director/officecommunications-public-liaison/clear-communication/plainlanguage/plain-language-getting-started-or-brushing

Specifically, complete transparency in terms of how Federal money is spent on scientific research and clinical trials has reached the forefront of public interest. In response, the two major scientific funding agencies in the USA (the National Institutes of health and the National Science Foundation) have joined forces to create a “Guide to Accelerate Public Access to Research Data” (which is aimed at funding agencies and University Research research administrators to facilitate fast translation of scientific data to the public arena. In addition, all clinical trials involving US citizens as subjects must be registered with ClinicalTrials.gov. This ensures that all trials are available to the public for enrolment, and all data must be open-access, whether it is published in a peer-reviewed journal or not. Both the NIH and NSF require a plain-language abstract to be submitted with any application for funding, which becomes publicly accessible upon approval of funding. The International Society of Medical Publications Professionals has a guideline for Journals including a strong recommendation to require a publicly-accessible abstract of the manuscript. It is not yet mandatory, but adoption of this practice is increasing. More information on this initiative and a list of Journals that adhere can be found on their website and in their excellent podcasts https://www.ismpp.org/index.php?option=com_content&view=article&id=463:ismpp-podcasts2020&catid=39:podcasts All these measures have contributed to a more open research communication style and can only be beneficial.

Barriers to effective communication Despite recent efforts discussed above, clear communication of scientific ideas to the public still faces barriers. It is not as simple as making the language readable.

One major barrier is trust; mainly the public’s trust of science presented by scientists and doctors in a patronizing fashion, or at an inappropriate level. Trust has been eroded by bad players and heinous historical events including the USPHS Syphilis Study at Tuskegee.

This trust must be earned back by clear and respectful communications and involvement of “citizen science” in the development and design of clinical trials. In terms of innovation, trust is essential for adoption of new ideas. One communication barrier is that presented by premature release of untested results, leading to retraction of data and sometimes funding. This is sometimes a result of oversimplification by the popular press, but sometimes,

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unfortunately, premature release of information by researchers. There is an organization devoted to catching and assisting in tracking these retractions, in the interests of maintaining scientific integrity and preventing the spread of misinformation. Retraction Watch https://retractionwatch.com/ “tracking retractions as a window into the scientific process”) is a publicly-funded invaluable resource for anyone interested in research and innovation, and has an active messaging section for pepe to report articles they find.

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In many communities in the world, there is a taboo on certain aspects of medical intervention and research. For example, Jehovah’s Witnesses do not take most medications and will not submit to blood transfusions. We, as researchers and innovators, need to be sensitive to these cultural and religious differences, and where possible, accommodate them. For example, at Cincinnati Children’s Hospital, when a child of a First Nation passes away, they are moved to a room with a window that opens, to allow their soul to escape. The newly redesigned morgue includes many accommodations for various religious and spiritual practices, which is an innovation led by the palliative care team and the multi-faith chaplaincy.

The archnemesis of every new idea “This is the way we have aways done it!

Only by listening to the end-user, paying attention to their physical and other needs, can innovators for truly transformative ideas and tailor their products for maximum impact.

Fear of, or resistance to, change is a major barrier in any field, including healthcare. Even with effective communication and thoughtful inclusion with thorough testing and agency approvals, there will always be those who are fearful of change, and I am including physicians in this statement. Common responses to innovations include: ”but XXX procedure works, why would we adopt a new way?”, “I will wait until it has been used for a few years” and the arch-nemesis of every new idea “This is the way we have aways done it!” While we cannot make all the people happy all the time, we must also take some responsibility for this, as communicators.

Perhaps we have not been clear enough in describing the advantages of the new approach? A good way to test this out is to have a non-academic, non-scientist panel to review your communication to gauge their response. Examine their questions and requests for clarity. Ask them questions about their comprehension of the writing and make sur the message was clear. I have personally learned a lot from teaching where students must give feedback at the end of the lecture series.

A trend termed “Citizen Science” has recently become popular. This is the involvement of the public in design, testing and implementation of innovations. The Government website https://www.citizenscience.gov/# is an official channel to get involved, and I highly recommend looking through their resources. Their efforts are not confined to healthcare, and include environmental and ecological monitoring. Inviting participation in the procedure of bringing a process, drug or device into clinical practice and public use fosters a more trusting relationship. It also allows feedback at all stages, saving time and public money in this costly endeavor. Overall, people want to be involved in the processes and decisions that ultimately affect them; we feel more vested in the end product and trust the data supporting its use.

To summarize Making research findings available and useful to the innovator audience is not as basic as simplifying the language used.

114

Effective communication requires a thoughtful approach to the target audience and a clear understanding of what message we are really trying to convey. While a great deal of progress has been made in the last decade or so, including citizen science, plain language movements and transparency in publicly-funded research, there is clearly more that can be done. Join Innovation Express and others like us in supporting and facilitating this movement toward accessible information, which we know leads to disruptive innovations!

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CONTRIBUTERS WOULD YOU LIKE TO CONTRIUBUTE AN ARTICLE TO INNOVATION EXPRESS?

Want to share your work and knowledge with our audience? Innovation Express is currently seeking enthusiastic community members from all backgrounds to join our team of expert contributors. We are looking for academic, industry or policy initiatives that highlight and reduce disparities in healthcare

Tech

Pharma

Tech innovations in the healthcare sector designed to address issues related to underserved communities

Pharma innovations designed to address issues related to underserved communities

ARTICLE COMPENSATIONS BASED ON LENGTH AND ACCEPTANCE, INQUIRE FOR MORE DETAILS. Contact Us

Community Societies, organizations and community outreach initiatives targeted toward reducing disparities in healthcare provision, accessibility and inequities.

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INNOVATION IS THE ABILITY TO SEE CHANGE AS AN OPPORTUNITY NOT A THREAT -Steve Jobs

I founded Venja Health with a goal to use health technology to help millions of people. Motivated by family members with various healthcare challenges, I recognized two emerging epidemics with unmet needs: chronic diseases and loneliness My loved ones have chronic conditions including diabetes, kidney disease and cardiac disease. These were exacerbated by the pandemic and inspired me to consider closely the interplay between loneliness and mental health in people with chronic diseases.

Diseases classed as Chronic by the CDC, such as diabetes or hypertension, are, unfortunately, very prevalent and becoming more common.

A 2020 study issued by the CDC examined only 10 chronic conditions: arthritis, asthma, cancer, coronary heart disease, chronic obstructive pulmonary disease (COPD), diabetes, hepatitis, hypertension, kidney disease and stroke. innovationexpress.org

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These 10 conditions are responsible for ~450 million diagnoses in the US. On average this is more than one per American (including children). This is only considering those 10 conditions studied; there are thousands of other diagnoses that were not studied in detail and so it is likely that the average number of chronic diseases is much larger.

We tend to think of chronic diseases as a problem of the elderly, but they occur in younger adults and at alarming rates. In fact, about 16% of younger adults, ages 18-44 have 2 or more chronic conditions.[1] This equates to about 20 million American younger adults that are expected to have chronic diseases for their entire life.

Loneliness,

on

the

other

hand,

is

a

relatively

underrecognized epidemic, which has only worsened with the pandemic. In 2018, a Kaiser Family Foundation study reported that ~60 million Americans felt lonely.[2] During the pandemic, according to a Harvard study, this number has increased to 36%. In their study, 36% of respondents reported feeling lonely “frequently” or “almost all the time or

Some effects on the body include:[5, 6] Worsening hypertension (increase in blood pressure) Increased flight or flight response (increased norepinephrine), which can

all the time”.[3] This equates to almost 100 million

disrupt sleep and increase

Americans. This does not even take into consideration the

risk of long-term

global impact of loneliness.

inflammation

Loneliness not only has psychological effects, but it also

(increase in cortisol)

leads to negative physical effects. It has been reported that loneliness has a similar negative impact as smoking 15 cigarettes per day.[4]

Increased stress hormones Increase risk of stroke Increased risk of heart disease Higher mortality rate

Loneliness and chronic disease lead to a vicious cycle. As noted above, loneliness can have a negative health impact. In turn, chronic diseases such as diabetes lead to social isolation and loneliness.

There are also genetic factors that contribute to the development of loneliness and chronic diseases in people. Certain genetic mutations have been associated with loneliness and the interplay between the genetic predisposition for loneliness and the development of chronic diseases such as coronary heart disease. [7, 8] To combat chronic diseases and loneliness Venja Health is building a health tracker mobile app with genetics / personalized medicine platform. The app helps people track their health, symptoms, mood and voice biomarkers and it connects them anonymously to others for accountability and support.

The genetic information allows for personalized insights into people's health and behavior.

Taken all together, Venja Health is working towards helping people build happier, healthier lives. We will present our technology at Innovation Theater at AHIS2022.

To receive updates on our journey, you can subscribe to email list at https://www.venjahealth.com

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1. Boersma P, Black LI, Ward BW. Prevalence of Multiple Chronic Conditions Among US Adults, 2018. Prev Chronic Dis 2020;17:200130. DOI: http://dx.doi.org/10.5888/pcd17.200130external icon.

2. https://www.cdc.gov/pcd/issues/2020/20_0130.htm#:~:text=In%202018%2C%205 1.8%25%20of%20US,those%20living%20in%20rural%20areas.

3. Kaiser Family Foundation, 2018. https://www.kff.org/report-section/lonelinessand-social-isolation-in-the-united-states-the-united-kingdom-and-japanan-international-survey-introduction/ 4. Harvard, 2020. https://mcc.gse.harvard.edu/reports/loneliness-in-america 5. Kidambi, N., & Lee, E. E. (2020). Insight into Potential Mechanisms Linking Loneliness and Cognitive Decline: Commentary on "Health Factors as Potential Mediator the Longitudinal Effect of Loneliness on General Cognitive Ability". The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 28(12), 1284–1286. https://doi.org/10.1016/j.jagp.2020.08.015 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452903/#:~:text=Loneliness%20 impacts%20mental%20and%20physical,decline%2C%20and%20shrinking%20soci al%20networks.

6. CDC. https://www.cdc.gov/aging/publications/features/lonely-olderadults.html 7. Cleveland Clinic. https://health.clevelandclinic.org/what-happens-in-yourbody-when-youre-lonely/ 8. Abdellaoui A, Sanchez-Roige S, Sealock J, Treur JL, Dennis J, Fontanillas P, Elson S; 23andme Research Team, Nivard MG, Ip HF, van der Zee M, Baselmans BML, Hottenga JJ, Willemsen G, Mosing M, Lu Y, Pedersen NL, Denys D, Amin N, M van Duijn C, Szilagyi I, Tiemeier H, Neumann A, Verweij KJH, Cacioppo S, Cacioppo JT, Davis LK, Palmer AA, Boomsma DI. Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness. Hum Mol Genet.

2019 Nov 15;28(22):3853-3865. doi: 10.1093/hmg/ddz219. PMID: 31518406; PMCID: PMC6935385.

9. Dennis J, Sealock J, Levinson RT, Farber-Eger E, Franco J, Fong S, Straub P, Hucks D, Song WL, Linton MF, Fontanillas P, Elson SL, Ruderfer D, Abdellaoui A, SanchezRoige S, Palmer AA, Boomsma DI, Cox NJ, Chen G, Mosley JD, Wells QS, Davis LK. Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease. Mol Psychiatry. 2021 Aug;26(8):42544264. doi: 10.1038/s41380-019-0614-y. Epub 2019 Dec 3. PMID: 31796895; PMCID: PMC7266730.

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In a world that's vastly changing and evolving, we do our best to keep up with the demands of the world. In hopes that what we work hard for the return of investment is greater. Often times we marginalize and overlook the truths of our past as if it doesn't exist, when in doubt our foundation, and past trauma plays a major role in how we maneuver throughout our daily lives and contributes to our relationships and success. Mental health has always been a topic that nobody really cares to broadcast for various reasons until something becomes tragic and it's over the news. Jessica Reliford presents her new book,

Jessica Reliford A Daughter's Cry From Unveiled Secrets to Fulfillment, where she uses writing as a therapeutic instrument to explain her story of events and as a way of healing, inspiring, and encouraging others to change the narrative of their story. Mental health is far more important than what society bares to address. It's time to be pioneers for our youth that are not only watching us but also be examples of how 'WE" chose to tackle obstacles that were meant to destroy us and provide the tools needed for them to succeed.

Get Your Copy Today

#MentalHealthMatters

UNDER THE SCOPE

HEALTHCARE EVENTS THAT NEED TO BE ON YOUR CALENDAR AUGUST 27 CINCINNATI OHIO

ADVANCING HEALTHCARE INNOVATION SUMMIT T

his summit provides a platform for

participants to share experiences and knowledge about best practices of promoting innovations in healthcare. It promotes young innovators and researchers to share their idea, findings results of their latest innovative projects and interact with experts of all disciplines.

THIS YEAR'S THEME: CONNECTING THE DOTS Objectives: Learning innovative approaches to improve health and to decrease disparities in healthcare Educating innovators and offering opportunities to showcase work, network, etc..

Highlighting the latest innovative projects, products and developments in healthcare.

SEPTEMBER 7-9 WAHINGTON, D.C.

NATIONAL ASSOCIATION OF ACOS FALL CONFERENCE T

he agenda will feature leading ACO experts and CMS officials sharing timely and essential information for ACOs. As always, the entire conference will be recorded and all participants,

MARCH 11, 2023, CINCINNATI OHIO

both in-person and virtual, will be able to view any sessions they missed live for six months following the conference.

NAACOS conferences are the only events organized exclusively by ACOs with more than 70 percent of attendees employed

by ACOs. Attendees at the spring conference will

PRECISION ONCOLOGY FORUM Closing the Gap Between Knowledge & Practice

Clinical Leaders of ACOs

Highlighting the latest advances in Precision Oncology & Regenerative Health.

Learning ways to implement this knowledge into practice. Networking with experts and exhibitors will happen during schedule breaks and reception Dinner

Administrators of ACOs

LEARN MORE WWW.INNOVATIVEHCI.COM

be:

Executives considering the ACO model CMS Officials Private Payers Industry Partners

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STRATEGIC OVERVIEW THE

OF

XAVIER

CENTER

FOR

INNOVATION (XCFI)

Ben Alegre (Coordinator) & Dr. Rashmi Assudani. Xavier Center for Innovation

Many people often think innovation is only applicable in a business setting where new technology and products are developed. While innovation does showcase itself in that dynamic, it is certainly not limited to just the newest annual smartphone release. Instead, innovation can be seen in a variety of disciplines. Innovation doesn’t always have to be a completely new invention either, it can also lie within the optimization of existing products to make them even better. In many business accelerators and incubators across the city of Cincinnati and beyond we are starting to see more and more medical technologies developed that better the lives of the average citizen or make the lives of medical professionals easier. Cincinnati is a top 10 U.S. city for startups and innovation, and this is a city with a large intellectual and human capital in healthcare. Therefore, there is an opportunity in this city to weave innovation with healthcare. Universities can serve an important facilitative role in enhancing the innovative ecosystem here in Cincinnati.

In order to give more students an opportunity to bolster their innovative thinking, Xavier University has reignited the Center for Innovation (CFI) as a focal point for student involvement on campus.

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The Center is strategically positioned to be an experiential, interdisciplinary, and mission focused center. What the CFI CFI

AIMS

AS

A

TO

SERVE

CONNECTIVE

TISSUE

BETWEEN

STAKEHOLDERS AS

ALUMNI,

THE

SUCH THE

ENTREPRENEURIAL ECOSYSTEM

OF

CINCINNATI, FACULTY OF

AND

XAVIER,

STUDENTS,

STAFF

AND

THE

WHO

ARE

COMMITTED INNOVATION

TO AND

ENTREPRENEURSHIP.

(https://www.xavier.edu/center-for-innovation/index) aims to do is bridge the gap between classroom learnings and real-world experiences through experiential learning such as internships, guest speakers, launching a student business or running a student-run business on campus. CFI aims to serve as a connective tissue between the stakeholders such as alumni, the entrepreneurial ecosystem of Cincinnati, faculty and staff of Xavier, and the students, who are committed to innovation and entrepreneurship. What is distinct about us is our commitment to innovation and entrepreneurship bolstered by our Jesuit mission that propels us to serve the underserved, to serve with kinship and solidarity, and to advance ethical learning and growth. We are identified by US News and World Report as one of the top 25 schools for entrepreneurship, and we are committed to leveraging and supporting Cincinnati’s innovation and entrepreneurship community to enhance Cincinnati’s place on the national and global platform.

One of the pillars for CFI is that it can be a support system for sustainable student-run business that allows for students to learn experientially how to run a small startup by doing pitch competitions and local cohorts for the next world-changing innovation. Another key focus is mission-based entrepreneurship, which falls closely in line with social innovations. Last year, the center hosted an innovation weekend where student teams spent a weekend preparing a pitch to address food insecurity on campus. This was a perfect example of students from a variety of backgrounds coming together to solve a problem that betters the lives of other students.

One of the opportunities in social innovations is to address the healthcare inequities in the United States. With the U.S. population health and global health changing so rapidly, innovation is the key to maximizing return on investment. So many healthcare workers come up with amazing ideas with nowhere to take them. We want to be that hub where you can come with your ideas and let us help you design the tools of the future. We encourage all of our healthcare system students from nurses to therapists, bring your ideas and dreams to the innovation center and we can help them come true and test your products. We want to be that hub where we can facilitate innovation between the large healthcare organizations and the start-up community focused and passionate about healthcare.

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Our

MISSION Innovation Express is a multi-media healthcare news hub designed to share all IHCI events and programs and announce the most innovative items in healthcare.

Contributors with different backgrounds will write the articles and they will range from bio’s of innovators, technology discoveries, meeting minutes, highlights from IHCI latest events and interviews with top innovators

Subscribe

Here

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Follow Us on Social Media Get Connected for Our Latest News & Updates

on Twitter @InnoXpress

on LinkedIn @LinkedIN.co/Innovation-Express

Website www.innovationexpress.org

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GROW YOUR

BUSINESS WITH US

We want to feature you!

We are looking for advertisers and articles for Innovation Express Magazine Reach our network of over 150,000 people worldwide.

We are looking for: Startups Healthcare companies Wellness companies Tech companies Innovatiors

info@innovtionexpress.org www.innovationexpress.org

Contact Us Today

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pg 39

INNOVATION EXPRESS MAGAZINE

MEET THE CONTRIBUTORS Melinda B. Chu, M.D. M.B.A. Recognizing and addressing loneliness as a prevalent healthcare need.

Melinda B. Chu,. is a physician-entrepreneur with 10+ years of clinical research experience. She graduated from Princeton University with a degree in History of Medicine. She received her M.D. degree and did her training at Saint Louis University. She completed her MBA at Washington University Olin Business School. Dr. Chu has 17 academic publications and she has served as an investigator on and developed numerous clinical trials. Dr. Chu is passionate about digital health because she wants to make a positive impact on the health of millions of people.

Elan Somasundaram, PhD.: Book Review (Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again) Elan is a junior faculty at Cincinnati Children’s Hospital Medical Center with a primary research focus on translational AI applications for pediatrics. He is also the associate director of the Children’s Artificial Intelligence Imaging Research (CAIIR) center and is responsible for development and translation of imaging focused AI applications across multiple disciplines. His duties involve interacting with clinicians, data scientists and the enterprise IT team to formulate plans for adopting AI pipelines within existing clinical workflow and to build AI/ML lifecycle management solutions. Dr. Somasundaram has a PhD in Nuclear Engineering and Statistics and has 6 years of experience in the medical imaging field.

Ben Alegre (Coordinator) & Dr. Rashmi Assudani. Xavier Center for Innovation The Center for Innovation at Xavier University is excited to present a strategic overview of the CFI and how we can expand on the role Cincinnati plays as an Innovation Hub. Maria Esposito Ashton is a medical writer, pharmacist, drug information specialist and content developer with experience and expertise in clinical practice, academia and the pharmaceutical industry. She has authored and written multiple peer reviewed manuscripts, grant applications, articles and website content, and has developed, written and conducted training programs, continuing education programs and symposia for sales representatives, physicians, nurses and pharmacists.

Maria Esposito Ashton M.S., R.Ph., M.B.A. BlogWatch Nina Flanagan is a freelance healthcare journalist

Nina Flanagan:

and has covered everything from biotechnology

Precision Medicine –

to women’s health. She has been published in

Healthcare’s

Genetic Engineering & Biotechnology News, Promising Disrupter? Healthcare Dive, Integrative Practitioner, PharmaDD Magazine, Medsite, Newsweek, and

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many more publications.