Regional Biocontainment Lab (BRL) Brochure

Con t act Us We look forward to discussing how we can help support your research and development needs.

Farhang Alem Interim Director Biomedical Research Laboratory falem@gmu.edu br l.gm u .edu

Region al Biocon t ain m en t Lab

Mason?s 52,000 square-foot Biomedical Research Laboratory (BRL) was established in 2010 as one of 12 NIAID-funded regional biocontainment facilities to support infectious disease research and foster collaborations with other national and global laboratories. It operates as a central core facility to advance research and develop novel diagnostics, therapeutics, and vaccines against viral and bacterial infectious agents by a diverse population of internal and external investigators. The BRL provides full-service in vitro and in vivo support for faculty led projects, collaborative endeavors, and contracted work with external partners.

The BRL is fully approved and licensed for work by the CDC and USDA and is accredited by AAALAC.

An im al Capabilit ies The core offers access and support to researchers interested in animal model studies. Technical expertise is available for protocol development, animal husbandry/care, breeding, and research study planning and execution for the following: -

Mice and rats Hamsters

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Rabbits Ferrets

Cor e Capabilit ies Imaging and Cytometry Flow cytometry, cell sorting, in vitro visualization, and non-invasive animal imaging to monitor disease progression and organ function.

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Widefield and Confocal* Fluorescent Microscopy Spatial Imaging* In Vivo Imaging

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Flow Cytometry/Cell Sorting Small Particle Analyzer* PET/CT

Aerobiology The aerobiology core enables nose only and whole body exposure of animals with BSL-2 and BSL-3 aerosolized pathogens, testing aerosolized delivery of therapeutics and vaccines, and detection of aerosolized pathogens.

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WHY US

Available Pat h ogen s

Ot h er Capabilit ies

Pathogens the BRL is currently registered to work with: -

Bacillus anthracis Yersinia pestis Francisella Tularensis Burkholderia pseudomallei Brucella abortus Rickettsia prowazekii Burkhlderia mallei

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Germfree Class III Hoodline and Mobile Cart Biaera Automated Aerosol Generation System

VEEV, EEEV and WEEV Rift Valley Fever Virus West Nile Virus Dengue Virus Chikungunya SARS-CoV-2 Brucella melitensis

Equipment available for genomics, proteomics, cytokine, and single cell analysis: -

Single Cell Array* Live Cell Analysis* Surface Plasmon Resonance* Sequencing* qRT-PCR

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Fluorescent, Luminescent, and Absorbance Plate Reader Laser Capture Microdissection Ultra and High Speed Centrifuge Histology (Frozen and FFPE* ) * Coming Soon