Circle of Support

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CIRCLE 1000 R AISES OVE R

$1 . 1 MILLION IN 202 4

Dear Circle 1000 Community,

At our 37th annual Founders’ Celebration Brunch on May 30, we had something extra to celebrate: a clean bill of health for Deb McCune, who is not only a breast cancer survivor but also one of Circle 1000’s key liaisons at the Hoag Hospital Foundation. Deb took part in a heartwarming, emotional conversation with moderator Dori Holnagel, vice president of the Hoag Family Cancer Institute, along with Deb’s oncologist, Dr. Chaitali Nangia, and her nurse navigator, Traci Swenson. It was inspiring to hear how the very initiatives we support eased the cancer journey for someone who so graciously supports us. You can read more about Deb’s remarkable personal experience on page 13

Laughter filled the Balboa Bay Resort ballroom as this year’s keynote speaker, psychologist Dan Shapiro, PhD, blended comedy and profound insight in sharing his harrowing cancer journey. Despite multiple relapses, Dr. Shapiro survived cancer with his sense of humor intact. In closing, Dr. Shapiro commended Circle 1000, saying, “What you have done in creating this network of strong steel magnolia friends is remarkable.”

Indeed, we are proud to report our steel magnolia circle of friends raised $1,151,193.95 in 2024 on behalf of the Hoag Family Cancer Institute. That brings our 37-year total to more than $25 million. Your generous contributions are being allocated this year as follows:

$500,000

$310,000

$200,000

$50,100

$30,000

$40,100

$20,993

Recruitment and discretion of the new executive medical director

Development of early detection, surveillance, and science within the Hoag Family Cancer Institute

Arden Flamson Oncology Nurse Navigator Program

Sandy Sewell Nursing Scholarships

Oncology Nursing Symposium

Non-Nursing Education Fund

Oncology Staff Self-Care Service

Throughout the pages of this magazine, you will learn how those resources directly affect the world-class care at the Hoag Family Cancer Institute. As mother-daughter co-chairs, and the niece and great-niece of one of Circle 1000’s earliest members, we are proud of our group’s 37-year history of philanthropy. At the same time, we are looking toward the future. We were inspired to see women of all ages at the Founders’ Celebration Brunch. Your presence and support assure us that our impact on cancer care at Hoag will continue for generations to come.

Warmly,

Event Co-Chairs Mary V. Buckingham and Lacy Robertson with speaker Dan Shapiro, PhD
2024 Circle 1000 Founders’ Committee Co-Chairs
Mary V. Buckingham & Lacy Robertson

PLATINUM CIRCLE

Lynette Berg in memory of Richard H. Berg

Sue & John Hagestad

JW & Sandra Mitchell Foundation

Ginny & Peter Ueberroth

GOLD CIRCLE

Joan & Don Beall/ The Beall Family Foundation

Shelley & Philip Belling

Ranney Draper in memory of Priscilla Draper

The Kling Family Foundation by Jackie Glass

The Lewis Family Charitable Foundation

Martha Macnab

Lori & Joe McKay

Justin Wilson, Julie Wilson, Karen Linden, & Ranney Draper
John Hagestad & Sue Hagestad
Jackie Glass & Gillian Moxham
Lori McKay & Katie Maggard

DIAMOND CIRCLE

Anonymous

Edie Barvin

Vicki & Bill Booth

Mary O. & James O. Buckingham

Betsy & Pat Collins

Diane & Jim Connelly

Janet L. Curci

DDA Family Foundation

Sandy & Roger DeYoung

Carmela L. Du

The Frome Family Foundation

Mr. & Mrs. S. Michael Joseph

Carole McDonald

Melinda & Tony Moiso

Trish O ’ Donnell

Lisa & Barney Page

J.R. Selby

Jamie & Jamie Shepherdson

Stacy & Jeffery Stone

Terry Family Foundation

Christine & Bill Thormahlen

Katie & George Tuerk

Katharine M. & Martinus B. van der Steen

Jessica & Eric Werner

Nancy & Arn Youngman

Sheryl & Robert Anderson

Lin Auer

Mary O. Buckingham, Jim Buckingham, Mary V. Buckingham, Lacy Robertson, & Tim Robertson
Sarah Booth & Vicki Booth
Debbie Millar, Mari Frome, & Lynn McGarrity
Jessica Werner & Sue Hagestad
Jamie Shepherdson & Lauren McDonald
Georgina Jacobson, Carole McDonald, & Victoria LeVasseur
Michele Birket & Janet Curci
Sharon Henwood, Nancy Youngman, & Carol Berryman
Lois Madison & Lynn Joseph
Taryn Pilco & Shannon Tarnutzer Mike Crisp & Lin Auer
Pam Gilmour & Don Gilmour
Traci Swenson, Dori Holnagel, & Deb McCune
Lori Bendetti, Dorothy Bendetti, & Michelle Bendetti

EMERALD CIRCLE

Dorothy Bendetti

Bluewater Grill

Mary V. Buckingham

Seawind Properties, Laurie Cappello & Jeff Sewell in honor of Sandra Sewell

Laurie Kraus & Donnie Crevier

Kathie & Jim Flynn

Heather Gaughan Family

Alison & Dennis Gilmore

Pamela & Don Gilmour

Susan & Chip Graham in honor of Jackie Kuhn

Virginia & David Hanna Family Fund

Maralou Harrington

Laura Khouri & Michael Hayde

Dori Holnagel

Teri & Alan Hoops

The Irwin Family in memory of William Irwin

Karen Jaffe

Pat & Jerry Jones

Bethany & Tommy Knapp

Sally & Jim Knapp

Marianne & Tom Larkin

Karen Linden in memory of Tom Linden

Ann Lucas

Debbie Millar

Julie Mumma

Pam & Jim Muzzy

Linda & Jerry Neely

Kathy & Sam Perricone, Jr.

Connie & Ron Robertson

Michelle Rohe

Peter Rooney

Pam Selber

The Sence Foundation

Margie & Larry Smith

Nancy & Jeff Stack

Shannon Tarnutzer

Graham & Annie McCray Tingler

Marilyn von KleinSmid

Joy & Bryon Ward

Victoria & Jim Warmington

The Weeks Family

Shanel & Justin Wheeler

Gay Williams in memory of

Juanita Firestone

Shanel Wheeler, Marianne Larkin, Lacy Robertson, Katie Maggard, & Jessica Werner
Jackie Westland, Caroline Graham, Susan Graham, Samantha Meek, & Beth Knapp
Dana Lucas Cipolla, Ann Lucas, & Kally Lucas Rapsey
Kristen von KleinSmid & Lauren von KleinSmid
Debbie Millar & Stephanie Brinton
Stephanie Grody & Sheryl Anderson
Tim Robertson, Lacy Robertson, Mary V. Buckingham, & Hillary Bryant
Laurie Cappello & Jeff Sewell
Gail Duesler, Pam Selber, & Aldy Jerney

RUBY CIRCLE

RUBY CIRCLE

� � � �

Ginger & Tony Allen

Ginger & Tony Allen

Hyla Bertea/ Whitecross Foundation

Hyla Bertea/ Whitecross Foundation

Sue & Greg Brakovich

Sue & Greg Brakovich

The Cannery, Louie ’s by the Bay

The Cannery, Louie ’s by the Bay

Michael J. Crisp

Michael J. Crisp

Mary Allyn Dexter

Mary Allyn Dexter

Laurie & Jake Easton

Laurie & Jake Easton

Sandy Fainbarg

Sandy Fainbarg

The Gordon Foundation

The Gordon Foundation

Karina & Bob Hamilton

Karina & Bob Hamilton

Larry Tucker & Jill Johnson-Tucker

Larry Tucker & Jill Johnson-Tucker

Devon Kelly

Devon Kelly

Helen & Peter Maxwell

Helen & Peter Maxwell

Suki McCardle

Suki McCardle

Kathy & Ron Merriman

Kathy & Ron Merriman

Donna Miller

Donna Miller

Ann & Michael Moorhead

Ann & Michael Moorhead

Pacific Hospitalist Associates

Pacific Hospitalist Associates

Karen, Kevin, & Kristen Rabe

Karen, Kevin, & Kristen Rabe

Janet & Dennis Shannon

Janet & Dennis Shannon

Shelton Family

Shelton Family

Paula & John Stanek

Paula & John Stanek

Kyle & David Team

Kyle & David Team

Heidi Ueberroth

Heidi Ueberroth

Keri Ueberroth

Keri Ueberroth

Polly & Joe Ueberroth

Polly & Joe Ueberroth

SAPPHIRE CIRCLE

SAPPHIRE CIRCLE

Mary & Dick Allen

Mary & Dick Allen

Frances Applegate

Frances Applegate

William Applegate

William Applegate

Kandis & David Arnold

Kandis & David Arnold

Jill & John Aschieris

Jill & John Aschieris

Dr. & Mrs. Rudolph C. Baldoni

Dr. & Mrs. Rudolph C. Baldoni

Pamela Banks

Pamela Banks

Judy & Richard Bauer

Judy & Richard Bauer

Trish & Mike Berchtold

Trish & Mike Berchtold

Nancy Pickett, Sue Brakovich, Diane Brown, & Annette McKnight
Ann Moorhead, Hyla Bertea, & Amy Vieth
Mary Allyn Dexter & Cindy Cotton
Kyle Team & Susan Sanders
Dick Allen & Mary Allen
Dick Allen & Mary Allen
Katie Pinkalla & Shelly Jacobs
Kristin Horgan, Brooke Shepherdson, Jessica Werner, Rachel Fowler, & Veronica Slavik

SAPPHIRE CIRCLE

Linda Bertone

Kim & John Bibb

Jan Blue

Lisa & Robert Braithwaite

Cindy & Dave Bright

Allyson Brooks, MD

Laura & Spike Broyles

Terry & Robert Callahan

Mr. & Mrs. William D. Campbell

Mary & Fenton Carey

Lesly & John Davenport

Lauri Delson

Richard Dick & Dee Pritchard-Dick

Denise & John Duncan

Phyllis Easton

Fran Farrer

Sherry & Warren Fix

Mr. & Mrs. Michael Flamson

Maureen Flanagan

- JP Morgan Advisors

Tracy & Steve Friedmann

Barbara & Steve Gale

Stephanie & Ken Grody

Mr. Andrew Guarni

Lisa & Mark Harryman

Diane & Jeff Heimstaedt

Jan Turner Hering & J.Clark Booth in memory of

Kay & John Turner

Susan & Peter Hitch

Mimi & Tom Hogan

Emily & Jeff Irwin

Rick John in memory of Rosalind Williams John

Betsy & Ray King

Vida & Greg Knapp

Michael M. Krug

Joan & Ron Lane

Katie & Ben Maggard

Jane Manolakas

Wendy Martini

Pamela Massey

Deb & Tim McCune

Marilyn W. McIntyre

Cindy McKee

Liz & Peter McKinley

Barbara & Ed Meserve

Gretchen & Dick Miller

Kathy & Michael Pearlman

Taryn Pilco, Shanel Wheeler, Gigi Kroll, Kathy O'Donnell, Chanel Pyle, & Kally Lucas Rapsey
Carolyn McKitterick, Jean Sigler, & Trish Berchtold
Pam Massey
Dorothy Baldoni & Rudy Baldoni
Mike Crisp, Lin Auer, Mimi Thompson, & Mike Thompson Terry Callahan & Bob Callahan
Erica Grant, Bill Applegate, Fran Applegate, Jill Aschieris, John Aschieris, Maddie Aschieris, & Jeff Aschieris

SAPPHIRE CIRCLE

The Dorthea Perrin Trust

Sidney Petersen

Nancy & Gary Pickett

Katherine Pinkalla

Chanel Pyle

Mary & Pete Rabbitt

Lacy & Tim Robertson

Jill & Tom Schriber

Veronica Slavik

Cindy & Al Stokke

Mimi & Mike Thompson

Jean & Tim Weiss

Julie & Justin Wilson

Corky & Bob Winters

Lloyd Wise

Tracy Wood

Anne Worrell

PEARL CIRCLE

Anonymous

Robert A. Alleborn

Kathie Armstrong

Diane Bailey

Mr. & Mrs. Sharad Bansal

Bonnie Barrington

Sheri & Bob Best

Mr. & Mrs. Henry Buckingham

Joey Buckingham in memory of Bill Buckingham

Carnahan Family

Julieanne Carpenter

Thomas Hogan & Mimi Hogan
Kimberly Bibb & Lauren Bibb
Lori McKay, Katie Maggard, Mary V. Buckingham, Dan Shapiro, & Lacy Robertson
Laura Hart & Tracy Friedmann
Barbara Meserve, Judy Bauer, Pam Howard, Penny Rauth, Kathy Robinson, Corky Winters, Sheila Collins, & Susan Stiefel
Lin Auer & Maureen Flanagan Cindy Stokke & Andrea Stokke Michael Krug & Maya Krug

News Briefs from the Hoag Family Cancer Institute &

the Circle 1000 Community

Circle 1000 Funds 19th Oncology Nursing Conference

Program moderator Tina Tillman, MSN, RN, opened Hoag’s 19th annual “Embracing Excellence in Oncology Nursing Practice” conference on June 14 by thanking Circle 1000. That’s because Circle 1000 provides critical funding each year for the two-day conference, held both virtually and in person at the Waterfront Beach Resort in Huntington Beach. This year, nearly 300 oncology nursing professionals from 20 different states attended sessions on a wide range of topics, from the latest in pharmacologic treatments and pain management to legal issues in oncology nursing and honoring patients’ spiritual lives.

Among the disease-focused sessions was a presentation by Dr. Simon Khagi, medical director of neuro-oncology, who was recruited to the Hoag Family Cancer Institute from Dartmouth Cancer Center last year, in part with Circle 1000 funding. Dr. Khagi discussed recent developments in detecting and treating brain and spine tumors, including the Optune Gio®, an electronic device worn on the head to slow the progression of glioblastoma along with chemotherapy. Among patients wearing the device, five-year survival improved from 5% to 13%.

A surprisingly high point of the conference was the closing presentation on death and dying by Julie McFadden, BSN, RN. Widely followed on social media as @hospicenursejulie and the author of the new book Nothing to Fear, McFadden normalized the discussion of death. The former ICU nurse recalled when she asked herself a tough question: “What if death is not the worst possible answer? What if suffering is worse?” The answer prompted her to become

a hospice nurse. “Hospice is about living, even though people are dying,” she said, poignantly describing the peaceful and natural process by which her patients die.

As the conference ended, the online chat reflected participants’ appreciation. Comments included: “This was one of the best conferences I have attended,” “It was so informative,” and “This conference

Hoag Leads the World in Launching Two Prostate Cancer Trials

Hoag became the first site worldwide to open and enroll patients in two groundbreaking clinical trials on prostate cancer. Both trials were launched last spring under the leadership of Gary A. Ulaner, MD, PhD, FACNM, James & Pamela Muzzy Endowed Chair in Molecular Imaging and Therapy, who was recruited to the Hoag Family Cancer Institute in part with Circle 1000 funding. The MIRROR trial is investigating the use of the molecular imaging agent PYLARIFY® alongside PET/CET scans to detect whether metastasis has occurred in men with favorable intermediate prostate cancer. “Our findings could revolutionize how patients are imaged, treated, and managed,” Dr. Ulaner said.

The second trial could enhance treatment options for patients with metastatic prostate cancer. It investigates the use of prostatespecific membrane antigen (PSMA)-targeted therapy prior to chemotherapy rather than after, which is the current standard of care. The study could allow some patients to avoid chemotherapy since other clinical trials have shown PSMA-targeted therapies to be more effective and less toxic than chemotherapy.

The rapid launch of these trials reflects Hoag’s nimble approach to research, with minimal red tape for physician-scientists. Circle 1000 has helped fund the expansion of HFCI’s research program, which allows eligible local patients to benefit from enrolling in these and other potentially groundbreaking trials.

Circle 1000’s philanthropy helped recruit Dr. Wang to Hoag from Memorial Sloan Kettering Cancer Center in 2022. In addition to his service to the community, Dr. Wang is known for bringing the Vectra WB360, a whole-body imaging system that screens high-risk patients for melanoma, to Hoag. The company he co-founded, Zenon Life, created the skinperfecting serum samples we received at this year’s Founders’ Celebration Brunch. Thank you, Dr. Wang! Save Our Heroes Day Offers Firefighters

More than 50 active and retired firefighters received complimentary skin cancer screenings at Hoag Health Center Irvine’s inaugural Save Our Heroes day on May 6. Among the many dangers firefighters face is an elevated risk of skin cancer due to exposure to carcinogens. Dr. Steven Wang, director of dermatologic oncology at the Hoag Family Cancer Institute, coordinated with Orange County Professional Firefighters, Local 3631 to plan the screenings on Melanoma Monday during Skin Cancer Awareness Month. “We wanted to do something to show our appreciation to the heroes,” Dr. Wang said.

Circle Expands with Third Generation

More third-generation Circle 1000 members and their friends attended this year’s Founders’ Celebration Brunch than ever before. The future of Circle 1000 depends upon this next generation to continue supporting the Hoag Family Cancer Institute in its mission to end cancer. Upon seeing this photo of young faces in attendance—themselves included—Circle 1000 committee members said, “Lots of friendships represented in this photo,” and “An amazing group of women.”

BACK ROW FROM LEFT: Nicole Joseph, Lindsey Hauschka, Lauren Liljestrom, Julie Sbicca, Carly Bennett Omer, Taryn Pilco, Kally Lucas Rapsey, Connie Pavlovich, Katie Maggard (peeking through), Courtney DeBeikes, Danielle Foster, Casey Bush, Beth Root, Anne Stiefel, Stephanie Hollern, Taylor Lingenfelter, and Laura Constantiner; FRONT ROW FROM LEFT: Christine Wang, Neda Roshdieh, Shelly Jacobs (bending down between front and back rows), Katie Pinkalla, Hanci Song, Shanel Wheeler, Marianne Larkin, Lacy Robertson, Jessica Werner, Dailey Packer, Chanel Pyle, Janelle Irwin, Barbara Botsford, Cecily Ginger, Kathy O’Donnell, and Jessica Ghaffarzadeh

“Circle of Caregivers” Guides Foundation’s Circle 1000 Staffer

Through Cancer Journey

DEB MCCUNE CALLS her Hoag Family Cancer Institute team her “Circle of Caregivers.” It’s a fitting term for the people who wrapped her in loving support through her recent breast cancer diagnosis and treatment. But Deb’s caregivers are also her colleagues. As executive director of strategic engagement at the Hoag Hospital Foundation, one of Deb’s primary responsibilities is to support Circle 1000.

Deb was first diagnosed with stage I breast cancer in 1995, while living in Colorado. She had long been cancer-free when she accepted her job at Hoag in 2011

“Little did I know what that decision would mean for my life,” Deb said. “One of my responsibilities was to work closely with the Circle 1000 Founders’ Committee. What a joy it has been! One of the first donors I met was Sandy Sewell. Sandy and I, both being breast cancer survivors, had a lot of stories to share.”

Traci Swenson, BSN, RN, OCN, and Deb McCune
“If it weren’t for philanthropy, these people literally would not have been there for me.�

As a survivor, Deb has always brought an extra dose of empathy to her job, but last year, her role with Circle 1000 took on new significance. Approaching 28 years of survivorship, Deb felt pain in her previously treated right breast. It was another tumor.

“I began my second journey with breast cancer with a band of warriors here at Hoag behind me,” Deb said.

Deb’s comments were made at the 37th annual Circle 1000 Founders’ Celebration Brunch in conversation with Dori Holnagel, vice president of the Hoag Family Cancer Institute. Joining the discussion were two members of Deb’s circle: her oncologist, Dr. Chaitali Nangia, and her nurse navigator, Traci Swenson, BSN, RN, OCN.

“If it weren’t for philanthropy, these people literally would not have been there for me,” Deb said after the brunch. Indeed, Circle 1000 has helped fund Dr. Nangia’s recruitment and research and Traci’s role in the Arden Flamson Oncology Nurse Navigator Program, along with other personnel and programs HFCI provided for

Deb. “I just want to emphasize how grateful I am for the support of Circle 1000 donors.”

Deb said her personal experience has only enhanced her purposeful work with the Foundation. “I better understand now the passion these donors show by sharing, by giving their gifts, because I was on the receiving end of that,” she said.

Two days after the brunch, Deb happened to sit beside a Circle 1000 member at a restaurant. The woman took Deb’s hand and proceeded to tell her how inspired she was by Deb’s story. Deb realized then that her story wasn’t just about her. “It was personal for the donors, too, in understanding their impact on one patient’s journey,” she said.

“There’s a secret sauce to any cancer patient’s journey,” Deb said at the brunch. “That is you, the donors. I have experienced, as have countless other patients at the cancer institute, the difference that you make.”

Deb McCune (center) shares her story at the Circle 1000 Founders’ Celebration Brunch with Dori Holnagel and members of her “Circle of Caregivers” Traci Swenson and Dr. Chaitali Nangia.

Cancer State of the Union Acknowledges Role of Philanthropy

EIGHT HOAG FAMILY Cancer Institute physician-scientists participated in an inspiring “Cancer State of the Union” on May 29. Many were recruited with philanthropy, which also supports their impactful research endeavors. “They’re committed to bringing the most promising novel treatments and innovations to our patients here in Orange County,” said Teresa Conk, senior vice president and chief clinical institutes officer, who moderated the panel.

BELOW ARE SUMMARIES OF SOME OF THE EXCITING DEVELOPMENTS DISCUSSED:

Carlos R. Becerra, MD

Margaret Givan Larkin Endowed Chair in Developmental Cancer Therapeutics and Medical Director of Hoag’s Cancer Clinical Research

“We’re continuing to expand the number of studies available for the population we serve here in Orange County so they don’t have to drive [far],” Dr. Becerra said. He added that sponsors are eager to open trials at Hoag because of the streamlined, less bureaucratic process and for the collaborative relationships being fostered with our physicians.

Tiffany L. Beck, MD, MPH, FACOG

Co-Director of Clinical Research Gynecologic Oncology

Dr. Beck said most ovarian cancer patients previously did not survive past five years. “Now we’re seeing survivors that are decades out,” she said. She credited immunotherapy and targeted molecular therapies for creating changes in the standard of care for ovarian and other gynecologic cancers.

David J. Benjamin, MD Medical Oncologist

Dr. Benjamin was a highly sought after graduate of UCI’s fellowship in genitourinary (GU) cancer. A co-author of more than 50 publications, he recently opened two phase III clinical trials, one in early-stage bladder cancer and the other for a rare form of kidney cancer. “The hope is that these therapies will one day be the standard of care,” he said, adding that they are already available to patients enrolled in the trials at Hoag.

Michael J. Demeure, MD, MBA, FACS, FACE

Otis Healy Family Endowed Chair in Applied Genomics and Program Director of the Hoag Precision Medicine Program

With more than 5 , 000 tumors genomically sequenced and a highly organized patient database, Dr. Demeure said Hoag can tailor treatment to each patient. The database also helps Hoag recruit patients quickly for trials. “We can highlight those patients and alert them that there is a drug or a trial [for their type of cancer],” Dr. Demeure said.

“ When you're taking care of cancer, it's not just the one specialist or one physician; it's a team of physicians,” Dr. Wang said. With support from Circle 1000, HFCI’s team is shaping the future of cancer care in Orange County and beyond.

Dr. Forrester joined Hoag in 2023 and is already launching a trial using an implantable device to deliver an immunotherapeutic agent to treat locally advanced pancreatic cancer. In the summer of 2024, Hoag became the second site in California with HistoSonics technology, an ultrasoundbased technique that uses ultrasonic pulses to shatter tumors, improving survival rates after colorectal cancer metastasis to the liver.

Dr. Kim thanked philanthropy for keeping Hoag at the forefront of radiation oncology technology, which he said advances faster than perhaps any other medical field. Using Hoag’s new MRI-guided radiation technology, “We’re able to image tumors in real time with MRI, and we can adapt [treatment] plans on a day-to-day basis,” he said.

Dr. Seery joined Hoag in part to conduct research on natural killer (NK) cell therapy, which stimulates the body’s immune system to fight cancer. “We did the first NK cell trial for pancreatic cancer,” Dr. Seery said, noting that philanthropy helped fund the technology for the trial, which drew patients from around the world.

With philanthropic support, Hoag recruited Dr. Wang and became the first hospital west of the Mississippi with the Vectra WB 360 whole-body imaging system. Using 92 cameras, the Vectra maps moles and lesions on patients at high risk for melanoma. “We can detect skin cancer early without having to do lots of unnecessary biopsies,” Dr. Wang said. “This device really jumpstarted the entire derm oncology program.”

FROM LEFT TO RIGHT: Teresa Conk, Dr. Brian Kim, Dr. Jared Forrester, Dr. Steven Wang, Dr. Tara Seery, Dr. Tiffany Beck, Dr. Carlos Becerra, Dr. David Benjamin, Dr. Michael Demeure, and Dori Holnagel

Novel Therapies Usher in New Era of Cancer Care

Thanks to Circle 1000’s Support for Cutting-Edge Cancer Research

AS HOAG�S CANCE R research program continues to expand, more early development clinical trials (phase I and phase II) are becoming available to patients for whom traditional treatment options have been exhausted. These early phase studies allow Hoag’s physician-scientists to explore the efficacy of novel therapies—carefully investigating dosages and identifying potential side effects—to discover new treatments that outshine chemotherapy and lower patients’ exposure to toxicity. Renewed hope for patients currently battling cancer is the beginning of what promises to become a revolution in the standard of care for a range of malignancies.

In 2022, the Hoag Family Cancer Institute opened 29 phase I and phase II trials, enrolling 19 patients. With continued support from Circle 1000, those numbers jumped in 2023 to 55 early phase clinical trials opened and 83 patients enrolled. In some cases, Hoag was the first to open these cutting-edge studies and remains one of only a few sites in the country to offer them directly to the community.

reengineering the immune system

To assist the body in identifying and attacking cancer cells, researchers at Hoag are using cellular therapies to enhance patients’ own immune systems. From activated antibodies and T cells to fluorescent dyes and modified bacteria, cellular therapies optimize immune system function with a range of genetically altered technologies. Through its commitment to cancer research, Circle 1000 is helping bring new chimeric antigen receptor (CAR)-T and natural killer (NK) cell therapy trials to Hoag.

Typically used to treat blood cancers like lymphoma and leukemia, CAR T-cell therapy is currently being studied on solid tumors under the leadership of Dr. Carlos Becerra, Margaret Givan Larkin Endowed Chair in Developmental Cancer Therapeutics and medical director of cancer research. Dr. Pooja Motwani, medical director of benign and malignant hematology, is working alongside Dr. Becerra to develop new protocols for CAR T-cell therapy patients. She is also laying the groundwork for the next iteration of immunotherapy studies coming to Hoag, including a new NK cell therapy trial for lymphoma.

While it typically takes an academic medical center roughly nine to 12 months to open a clinical trial, Hoag’s research team has streamlined this process to about 90 days. With each new trial opened, the Hoag Family Cancer Institute advances its reputation as a key partner for trial sponsors and for talented physicians looking to move cancer care forward.

Dr. Motwani

Oncology Power Couple Joins Hoag

Circle 1000 Aids in the Recruitment of Drs. Monica and Alain Mita

IN APRIL, HOAG welcomed academic researchers and oncologists Monica Mita, MD, MSc, MHDS, and Alain Mita, MD, MSc, from Cedars-Sinai Medical Center in Los Angeles. Thanks to support from Circle 1000, the husband-and-wife team is serving as co-directors of early phase development therapy to bring more groundbreaking cancer treatments to Hoag patients. Dr. Alain Mita is also acting as director of lung, head, and neck cancers while Dr. Monica Mita is working with Hoag’s breast cancer team as co-director of breast medical oncology. Each of their careers has focused on phase I and phase II research and drug development,

making the nationally recognized duo a perfect addition to Hoag’s growing cancer research team. According to Dr. Alain Mita, Hoag’s capacity to offer the latest clinical trials to patients made the organization stand out.

“We now have treatments available that we couldn’t have dreamed of 30 years ago: CAR T-cells, immunotherapy, targeted therapies— advances that are making a huge difference in how we are able to care for patients. These advanced treatments offered at the Hoag Family Cancer Institute are usually only available at large academic cancer centers, which makes Hoag so unique.”

Dr. Alain Mita and Dr. Monica Mita

Boldly Hoag Campaign Expands Opportunities for Circle 1000 Community

THE HOAG FAMILY Cancer Institute knows no boundaries in terms of quality care, and today, its physical boundaries are growing as well. Through the ambitious Boldly Hoag campaign to expand the Irvine campus, Hoag will reach more cancer patients than ever before. Many Circle 1000 members have decided to also support the Boldly Hoag campaign because it advances Circle 1000’s mission to elevate cancer care in Orange County and to eventually to find a cure.

“Our population base has moved down to the Irvine and South County areas,” said Lin Auer, 2023 Circle 1000 Founders’ Committee co-chair, who supports Boldly Hoag in part for the broader reach it facilitates.

“Your dollars that are going to Boldly Hoag are also helping Newport,” said Bethany Knapp, a longtime Circle 1000 member who likewise supports the campaign. “It’s the same hospital. They’re intertwined. It only raises up the level of care for everybody.”

Boldly Hoag supporters Bob and Terry Callahan at the 2024 Circle 1000 Founders’ Celebration Brunch
Rendering of the lobby of the Cancer and Digestive Health Pavilion on Hoag’s Sun Family Campus in Irvine, currently under construction.

With six new buildings, expanded research capabilities, innovative technology, and dedicated facilities for cancer and other specialty care, the new Sun Family Campus will enhance cancer care countywide. Patients who live closer to Irvine will gain easier access to programs we support and cherish, like Hoag’s cancer early detection programs, nurse navigators, and clinical trials.

“Hoag is going to have two amazing cancer facilities in Orange County,” said Terry Callahan, whose longtime philanthropy today includes both Circle 1000 and Boldly Hoag, and previously the Hoag Promise campaign and the 552 Club. “It will become such an integral part of the community and will draw more people to groups like Circle 1000 because of the quality of care.”

“With the growth of that campus, it is going to attract an even

wider range of physicians,” said Terry, referring to the Circle 1000-supported initiative to recruit and retain leading oncologists. “It will lead to the opportunity for more clinical trials.”

Boldly Hoag is also giving patients access to the most advanced medical technology. “We have multimillion dollar pieces of equipment and diagnostics available so close to us with the Hoag name and level of care,” Lin said.

Terry noted that even though their children live out of the area, she and her husband Bob will never move away from Hoag. “Bob will scream that from the rooftops,” she said. In fact, Bob recently spent a month in the vascular unit, which only reinforced the Callahans’ commitment to Boldly Hoag. “You never know when you or your family or a dear friend is going to need Hoag,” Terry said.

Redefining the Future of Health Care

The Boldly Hoag campaign is transforming Hoag from a community hospital to a national destination for patient care.

expanded campus

Physically, the campaign funds the expansion of Hoag’s centrally located Irvine campus to include nearly 1,000,000 square feet of buildings. The new facilities on the Sun Family Campus—named for the transformational $50 million gift from Diana and David Sun—marry the latest in medical technology with thoughtfully designed, flexible spaces.

elevated patient experience

Features such as modern rooms, wellness gardens, outdoor decks, and a spa-like atmosphere will elevate the patient experience.

physician recruitment and retention

By providing the resources to invest in advanced technology, cutting-edge research, and innovation, Boldly Hoag will help Hoag to recruit and retain leading physicians to work on both campuses.

Boldly Hoag is not only making Hoag the best it can be today; it is setting a new standard for the future of health care. To support the Boldly Hoag campaign, visit boldlyhoag.org.

Rendering of the expanded Sun Family Campus in Irvine.

Circle 1000 collectively raised $1,106,030 in 2023 to support the Hoag Family Cancer Institute.

Together, with HFCI leaders, our committee decided to steward these funds to the following programs and initiatives:

Physician Recruitment & Leadership

$400,000

IMPACT Funds supported the recruitment of Drs. Alain Mita, Monica Mita, and Ryan Reddy, as well as the cancer research and medical directorship for Dr. Carlos Becerra.

Research Expansion Including Cellular Therapy

$400,000

IMPACT Funds supported the expansion of HFCI’s research program, reaching 55 early-phase trials with 83 enrolled patients in 2023. Impact also includes the addition of four new clinical researchers since 2023: Drs. Simon Khagi, Alain Mita, Monica Mita, and Benjamin Goldenson.

Arden Flamson Oncology Nurse

Navigator Program

$200,000

IMPACT Supported nurse navigator staffing for breast cancer patient support.

Sandy Sewell Nursing Scholarships

$50,030

IMPACT Funded scholarships for two nurses to obtain continuing education: one at Newport Beach’s 8 West Oncology Unit and the other at the Irvine Cancer Outpatient Treatment Center.

Non-Nursing Education Fund

$23,000

IMPACT Supported education for non-nursing staff, including precision medicine specialist Dr. Sourat Darabi, medical physicist Jay Zheng, radiation oncology therapists, dosimetrists, nutritionists, and social workers.

“Embracing Excellence in Oncology

Nursing Practice” Conference

$23,000

IMPACT Two-day conference in June provided continuing education for nearly 300 nurses from Hoag and other institutions. Funding allows Hoag nurses to attend at no charge.

Oncology Staff Self-Care Service

$10,000

IMPACT Funded massage therapists who provided 15-minute massage breaks to 308 HFCI employees in 31 departments.

PEARL CIRCLE

Amy Claster

Edna & Rick Cole

Cecilia Crary

Jane Croul

Frank T. Curry, DDS, Inc.

Bettina Deininger

Mrs. Danielle Foster

Daisy Fuller

Adrienne Garrison

Marie Gray

Sue & Dan Guggenheim

Otis M. Healy

Pam & Mike Howard

Robin Ibbetson

Ryan Bean & Brett Kroha

Michelle Linovitz

Maureen & Nick Madigan

Debbie & Jeff Margolis

Helen & Peter Maxwell

Jessica McCormick

Megan McKay

Carolyn McKitterick

Sue Mears

Suzy Metcalfe

Brooke Montijo

Cynthia Niblo

Malia Petrucci

Therese K. Poitevin

Lynn Pyle

Mr. & Mrs. William Rauth

Lucy & Rick Rawlins

Teddie Ray

Francesca & Sam Rehnborg

Robins Family

Kathy Robinson

Bill Witte & Keiko Sakamoto

Heidi Shurtleff in honor of Lin Auer

Susan & Jim Simpson

Linda I. Smith

Hillary & Greg Stampley

Michael Stephens

Marilyn & Tom Sutton

Susan & Joe Thomas

Terri Turner

The Walters Family

Molly Walters

Christine & Tony Wang

Jill & Doug Wetton

Carol L. Wilken

Nancy Pickett, Sue Brakovich, Diane Brown, & Annette McKnight
Sydney Balalis, Paul Balalis, & Diane Bailey
Deb McCune & Terri Turner
Hanci Song, Neda Roshdieh, & Apoorva Jha-Bansal
Maribel Ley, Robin Ibbetson, Casey Hill, & Casey Walters
Heidi Shurtleff, Lin Auer, & Pamela Hoffman
Danielle Foster, Halleigh Hill, Jessica Wohl, Jessica Werner, Christine Wang, Alia Batniji, Chelsea Block, Dina Moatazedi, Meghann Butcher, & Anne Stiefel

OPAL CIRCLE

Julia & Robert Beaton

Chelsea Block

Botsford Family

Kate Collett

Laura & Mike Constantiner

Alison Davis

The Josh Davis Family

Courtney & Richard DeBeikes

Kathleen N. Feicht

Rachel Fowler

Cecily Ginger

Joan Halvajian

Robyn Hamilton

Heather Harwell

Kelly Lee Heyler

Casey Hill

Mrs. Halleigh Hill

Stephanie & Michael Hollern

Rosemarie Kuhn

Peter & Kirby Kurzeka

Cheryl & Mark Law

Lingenfelter Family

Linda P. Maggard

Colleen Manchester

Angela Margolis

Janice Markley

Liz & Rod Maxson

Elizabeth McCray/ Newton Family Fund

Mary McDonald

Alison & Joseph Miller

Judy Wilson Montgomery

Priscella J. Moore

Carly Omer

Harriet Lewis Pallette

Connie Pavlovich

Pamela & John Peterson

Kristin & Matt Robertson

Katie Russell

Katy & Jack Schoellerman

Mrs. Hanci Song

Mrs. Lauren Suryan

Stephanie & Todd Watts

The Wohl Family

Cory G. Youngberg

Lauren Liljestrom, Lauren Suryan, Shanel Wheeler, Lindsey Hauschka, Julie Sbicca, & Sarah Connolly
Harriet Lewis Pallette & Susie Johnson
Darlene Kuhn & Paul Kuhn
Judy Montgomery & Rose Kuhn
Joanne Verhoeven & Randall Verhoeven
Laura Constantiner & Taylor Lingenfelter

FOUNDE R S � COMMITTEE

MEMBE R S

Mary V. Buckingham*, Co-Chair

Lacy Robertson, Co-Chair

Sue Hagestad* Membership Chair

Sheryl Anderson*

Frances Applegate

Jill Aschieris

Lin Auer*

Vicki Booth*

Terry Callahan

Katie Flamson

Nikki Ham

Jan Turner Hering

Bethany Knapp*

Marianne Larkin*

Karen Linden*

Katie Maggard

Lori McKay

Ginny Ueberroth*

Kelli Weeks

Jessica Werner

Shanel Wheeler

Names highlighted in bold indicate members of the original 1987 Circle 1000 Founders’ Committee

*Past Chairs

Deborah Weitz, Karyn Davin, Katie Flamson, Tracy Wood, Malia Petrucci, Kellie Conrad, Laura Severson, & Kathleen Ellis
Jessica Werner, Laura Broyles, & Lisa Costa
Susan Anderson & Linda Bertone
Libby Knight & Lesly Davenport
Allyson Brooks, Kathy O ’ Donnell, & Elizabeth Kraft
Richard Dick & Dee Pritchard-Dick

Jill Ireland † – 1988

Betty Rollin – 1989

Nancy Reagan † – 1990

Peter Ueberroth – 1991

Dave Dravecky – 1992

Dr. Edward Rosenbaum † – 1993

Susan Nessim & Diana Golden † – 1994

Linda Ellerbee – 1995

Carol Krause – 1996

Harry Belafonte – 1997

Ted Kennedy, Jr. – 1998

Scott Hamilton – 1999

Barbara Barrie – 2000

Alan Hobson – 2001

Geraldine Ferraro † – 2002

Julia Sweeney – 2003

Hamilton Jordan † – 2004

Meredith Baxter Birney – 2005

Sam Donaldson – 2006

Lou Holtz – 2007

Tom Brokaw – 2008

Cokie Roberts – 2009

Ethan Zohn – 2010

Kelly Corrigan – 2011

Alan Hobson – 2012

Corina Morariu – 2013

Jamie Lee Curtis – 2014

Father Gregory Boyle – 2015

Shannon Miller – 2016

Joan Lunden – 2017

Karen Mills – 2018

Mack Dryden – 2019

Jake Olson – 2021

John Vallely – 2022

Hayley Arceneaux – 2023

Dan Shapiro – 2024 † Deceased

Hoag Hospital Foundation

Coufos Family Center for Philanthropy

330 Placentia Avenue

Newport Beach, CA 92663

RETURN SERVICE REQUESTED

Circle 1000 Founders� Committee

BACK ROW FROM LEFT: Sheryl Anderson*; Katie Maggard; Lori McKay; Katie Flamson; Beth Knapp*; Karen Linden*; Terry Callahan; Vicki Booth*; Shanel Wheeler; FRONT ROW FROM LEFT: Lin Auer*; Jessica Werner; Sue Hagestad*; Mary V. Buckingham*, Co-Chair; Lacy Robertson, Co-Chair; Marianne Larkin*; Jill Aschieris; Fran Applegate; NOT PICTURED: Nikki Ham; Jan Turner Hering; Ginny Ueberroth*; Kelli Weeks; Names highlighted in bold indicate members of the original 1987 Circle 1000 Founders’ Committee. *Past Chairs

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