ANNUAL REPORT 2010
REDMO
VOLUNTEER DONORS Available typed donors on December 31st 2010
86 361 â–˛ 8%
100000 90000 80000 70000 60000 50000 40000 30000 20000 10000 0 1994
1996
1998
2000
2002
„ Registered donors
2004
2006
2008
2010
Donors typed in 2010: 8 175
Current age of available typed donors 4000 3500 3000 2500 2000 1500 1000 500 0 18
20
22
24
26
Mean donor age: 42.6 years Standard deviation: +/- 9.8
28
30
32
34
36
38
40
42
44
46
48
Median age of donors: 42.2 years
50
52
54
VOLUNTEER DONORS
Donors per Autonomous Community Autonomy
Typed 2010
Total Actives
x 100 000 inh
1 545
14 001
167.25
Aragón
29
1 105
82.03
Asturias
91
2 156
198.83
Baleares (Islas)
157
1 612
145.74
Canarias
710
4 791
226.15
Cantabria
63
537
90.67
Castilla y León
528
5 644
220.51
Castilla – La Mancha
206
2 415
115.09
Catalunya
1 068
14 189
188.89
Comunidad Valenciana
1 821
9 381
183.52
Extremadura
145
3 154
284.85
Galicia
172
2 122
75.85
Madrid (Comunidad de)
649
8 982
139.07
Murcia (Región de)
279
5 944
406.57
Navarra (Comunidad Foral de)
471
5 677
891.31
País Vasco
144
3 770
173.07
Rioja (La)
80
600
186.10
Ciudad Autónoma de Ceuta
14
108
134.03
Ciudad Autónoma de Melilla
1
40
52.61
Andorra
2
133
158.18
8 175
86 361
176.97
Andalucía
Total
VOLUNTEER DONORS Registered volunteer donors per 1 000 inhabitants 160 140 120 100 80 60 40 20 0
Donors cancelled during 2010
2 145
Donors cancellation reasons Over 55 years
1 840
Disease
94
Untraceable
88
Voluntary withdrawal
46
Effective peripheral blood donation
32
Death
16
Ethical
15
Transferred to other registries
8
Other reasons
6
VOLUNTEER DONORS
Effective donations of haematopoietic stem cells during 2010
39
Per product Bone Marrow
6 (16%)
Periphera blood stem cells
32 (84%)
Lymphocytes
1 Collection Centres BM / PBSC / DLI
Hospital
BM
PBSC
DLI
Total
Hospital Virgen de la Arrixaca
0
3
0
3
Hospital Gregorio Marañón
0
2
0
2
Hospital Clínic de Barcelona
1
2
0
3
Centre de Transfusió i Banc de Teixits
0
4
0
4
Hospital de Donostia
1
3
0
4
Hospital Carlos Haya
1
1
0
2
Hospital Clínico de Salamanca
0
1
0
1
Hospital de la Princesa
1
3
1
5
Hospital Dr. Negrín
1
5
0
6
Fundación Jiménez Díaz
0
1
0
1
Hospital Son Espases
0
1
0
1
Hospital Puerta de Hierro
0
1
0
1
Hospital Ramón y Cajal
1
2
0
3
Hospital Central de Asturias
0
1
0
1
Complexo Hospitalario Univ. A Coruña
0
1
0
1
Hospital La Paz
0
1
0
1
Total
6
32
1
39
UMBILICAL CORD BLOOD Available cord blood units on December 2010
47 324 ▲ 13%
50000 45000 40000 35000 30000 25000 20000 15000 10000 5000 0 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
Available cord blood units
Cord Blood Units 2010: 5 767
Avaible Cord Blood Units per 1 000 inhabitants 3,5 3 2,5 2 1,5 1 0,5 0
UMBILICAL CORD BLOOD Cord Blood Units – Cord Blood Banks distribution Bank
Number
TNC
CD34+
> 1 x109
available
Málaga Castilla – La Mancha: 598; Murcia: 1
17 672
50%
69%
Barcelona Navarra: 764; Extremadura: 303; Aragón: 322; Baleares: 204; Cantabria: 94
13 779
71%
100%
Madrid La Rioja: 27
5 617
59%
89%
Galicia Castilla y León: 162; Asturias: 18
5 434
34%
98%
Valencia
4 140
57%
100%
Tenerife
455
34%
26%
País Vasco
186
100%
100%
39
33 %
100%
2
50%
100%
Vidacord Ivida 18000 16000 14000 12000 10000 8000 6000 4000 2000 0
Total
CD34+ available
TNC > 1x10^9
UMBILICAL CORD BLOOD Spanish Cord Blood Units provided during 2010
343
By originating banks Originating Bank
National patients
Foreign patients
Total
60 (41)
175 (101)
235 (142)
Málaga
7 (3)
45 (28)
52 (31)
Madrid
2 (9)
19 (17)
21 (26)
Valencia
3 (3)
16 (12)
19 (15)
Galicia
0 (0)
15 (13)
15 (13)
Tenerife
0 (0)
1 (2)
1(2)
País Vasco
0
0
0
Vidacord
0
0
0
Ivida
0
0
0
Total
72
271
343
Barcelona
Cord blood units provided by cord blood bank 250 200 150 100 50 0 2007 Barcelona
2008 Málaga
Madrid
2009 Valencia
2010 Galicia
Tenerife
Cumulative incidence of spanish donations
1800 1600 1400 1200 1000 800 600 400 200 0 1994
1996
1998
2000
2002
2004
2006
2008
Total donations*: 1 721 CBU (n= 1 332) [343] * DLI donations not included [2010 total activity]
PBSC (n= 230) [32]
BM (n= 159) [6]
2010
NATIONAL PATIENTS A. Searches started Searches started during 2010
768 ▲12%
Type of search Bone marrow / Peripheral blood
224 (29%)
Cord blood
13 (2%)
Bone marrow / Peripheral blood and Cord blood
531 (69%)
Search evolution for national patients
800 700 600 500 400 300 200 100 0 1992
1994
1996
1998
2000
2002
2004
2006
2008
2010
Searches started 2010: 768
■ CBU (n= 13)
PBSC / BM + CBU (n= 531)
PBSC / BM (n= 224)
NATIONAL PATIENTS
Searches started by community of residence of patient (n= 768) Autonomous Community
Number
x 100 000 inh
Andalucía
91
1.09
Aragón
10
0.74
Asturias
37
3.41
Baleares (Islas)
11
0.99
Canarias
21
0.99
Cantabria
24
4.05
Castilla y León
52
2.03
Castilla – La Mancha
15
0.71
163
2.17
Comunidad Valenciana
79
1.54
Extremadura
15
1.35
Galicia
53
1.89
Madrid (Comunidad de)
94
1.45
Murcia (Región de)
25
1.71
Navarra (Comunidad Foral de)
17
2.67
País Vasco
42
1.93
Rioja (La)
9
2.79
Ciudad Autónoma de Ceuta
1
1.24
Ciudad Autónoma de Melilla
0
0
Foreign
9
NA
Catalunya
NATIONAL PATIENTS
Searches started by diagnosis (n= 768) Acute Myeloblastic Leukaemia
213
Acute Lymphoblastic Leukaemia
127
Myelodysplastic disorders
83
Non-Hodgkin ‘sLymphoma
68
Other leukaemias
51
Hodgkin’s Lymphoma
47
Monoclonal gammopathy
44
Inherited erythrocytic abnormality
29
Severe aplastic anaemia
28
Chronic myeloid leukaemia
27
Other malignant disease
15
Inherited metabolic disease
13
Inherited Immune system disease
10
Histiocytosis
8
Other non malignant disease
5
NATIONAL PATIENTS Evolution of searches by main diagnoses
250
200
150
100
50
0 2002
2003
ALL
2004 AML
2005
2006
CML
2007
MDS
2008
2009
Lymphomas
2010
Cong. Dis.
Evolution of the mean age of searches 40
37 years 35
37 33
30 30 25
20
25 23
26
27
34
31
28
24
21
15 1998
2000
2002
2004
2006
2008
2010
NATIONAL PATIENTS
CBU selections made by the REDMO Office during 2010
164
Active searches on January 1st 2010
251
Active searches on December 31st 2010
268
Cancelled searches during 2010
764
Cancellation reasons Unrelated transplantion
404
National regulation (see detail*)
134
Death
124
Clinical Status
56
Related transplantion
12
Patient decision
12
Unrelated DLI infusion
9
Other (typing’s change, other therapy, transfer to other registries)
8
Autologous transplant
5
* Details of the searches cancelled due to national regulations Inactive searches for >1 year (without donor )
10
Inactive searches for >1 year (with donor )
77
Searches that have remained active 2 years
8
Searches that have remained active 1 year
39
NATIONAL PATIENTS
Inactive searches on December 31, 2010
203
Reason for inactive searches Suitable donor found Selected cord blood unit (infusion pending)
194 9
B. Localized donors Patients for whom one or more donors have bee located (BM / PBSC) Donors located during 2010 (BM / PBSC) Time to find the first BM / PBSC donor mean (days) Time to find the first BM / PBSC donor median (days)
477 â–˛10% 806 80 (SD: Âą 94) 48
Search time for BM / PBSC donors in percentages Before 3 months
79.9
Between 3 and 6 months
10.9
Between 7 and 9 months
4.8
Between 10 and 12 months
1.7
More than 12 months
2.7
NATIONAL PATIENTS Evolution of donors localized 800 700 600 500 400 300 200 100 0 1994
1996
1998
2000
2002
2004
2006
2008
2010
Donors found in 2010: 806
Median time to locate the first BM / PBSC donor 200 180 160 140 120 100 80
48 days
60 40 20 0 1996
1998
2000
2002
2004
2006
2008
2010
NATIONAL PATIENTS
Actuarial probability of locating a donor with 7/8 or 8/8 identities
1
2009
2008 2007
Probability of donor 7/8 or 8/8
0.8
2006 2010
0.6
0.4
Searches started in 2008-2010: 2006 Probability of donor 3 months = 52% 6 months = 64% 9 months = 69% 12 months = 72%
0.2
0 0
3
6
9
12
15
18
21
Months of search
24
27
30
33
36
NATIONAL PATIENTS C. Transplants Haematopoietic transplantions performed during 2010
404 ▲13%
By product Bone Marrow
83 (21%)
Peripheral blood setm cells
179 (44%)
Cord blood unit
142* (35%)
(lymphocytes infusion)
(9)
(*9 transplant performed with double cord)
Evolution of performed transplants 400 350 300 250 200 150 100 50 0 1994
1996
1998
2000
2002
2004
2006
2008
Transplant perfomed 2010: 404
■ CBU (n= 142)
PBSC (n= 179)
BM (n= 83)
2010
NATIONAL PATIENTS Transplant by country of origin BM / PBSC (n= 262) Germany
141
United States
67
United Kingdom
14
Spain
11
Portugal
8
France
6
Italy
5
Israel
2
Switzerland
2
Australia
1
Canada
1
Cyprus
1
Denmark
1
The Netherlands
1
Norway
1 Transplant by country of origin CBU* (n=142)
Spain
73
United States
54
Germany
9
Australia
6
France
5
Switzerland
2
Italy
1
Sweden
1
(* 9 double cord transplantation)
NATIONAL PATIENTS Actuarial probability of matching donor and transplantion
1 3018 searches started in 2006-2010 Probability of compatible donor
0,8
Probability
0,6
Probability of HSCT (with donor or cord blood)
0,4 Probability of HSCT (with a donor)
0,2
0 0
3
6
9
12
15
18
21
Months
24
27
30
33
36
39
NATIONALPATIENTS Transplants performed by Autonomous Community (2010) Baleares; 1; 0% Asturias; 15; 4% P. Vasco; 5; 1% Galicia; 27; 7%
Valencia; 58; 14%
Navarra; 7; 2% Andalucia; 55; 14%
Cantabria; 28; 7%
Castilla y León; 30; 7%
Murcia; 14; 3%
Madrid; 63; 16%
Catalunya; 101; 25%
Activity by Autonomous Comunity 120 100 80 60 40 20 0
Total trasplants
Transplant from same community
NATIONAL PATIENTS Summary REDMO activity (national patients)
7000 6000 5000 4000 3000 2000 1000 0
Started searches 1st donor located (BM/PBSC and CBU) (n=4796) Transplants (n=2668)
FOREIGN PATIENTS
Preliminary searches
16 654 ▲ 9%
Activated searches
1 230
Evolution of searches for foreign patients 20000 18000 16000 14000 12000 10000 8000 6000 4000 2000 0 1994
1996
1998
Preliminary Searches (n= 16 654)
2000
2002
2004
2006
2008
Activated searches (n=1 230)
2010
FOREIGN PATIENTS Requested tests
2 026
Performed tests
1 605
Evolution of performed tests 1800 1600 1400 1200 1000 800 600 400 200 0 2003
2004
2005
2006
2007
2008
2009
2010
FOREIGN PATIENTS
Haematopoietic stem cells transplant performed 2010
299
Transplants by product Bone marrow
2 (1%)
Peripheral blood stem cells
26 (9%)
Umbilical cord blood*
271 (90%)
(lymphocyte infusion)
(1)
* This corresponds to UCB units shipped. There is not confirmation of infusion in all cases.
Transplant by country of destination BM / PBSC (n= 28) Germany
10
France
6
United States
5
Argentina
1
Australia
1
Belgium
1
The Netherlands
1
Ireland
1
Portugal
1
United Kingdom
1
FOREIGN PATIENTS UCB shipments by country of destination (n= 271) France
67
United States
63
United Kingdom
34
Italy
21
Israel
11
The Netherlands
10
Germany
9
Colombia
8
Greece
8
Australia
5
Turkey
5
Argentina
4
Canada
3
Denmark
3
Hungary
3
Mexico
3
Belgium
2
Cuba
2
Portugal
2
Switzerland
2
Austria
1
Chile
1
Finland
1
Poland
1
Sweden
1
Uruguay
1
FOREIGN PATIENTS Transplant by country of destination BM / PBSC (n= 28)
Netherland 4%
Ireland 4%
Portugal 4%
United Kingdom 4%
Belgium 3% Australia 3% Argentina 3%
Germany 36%
United States 18% France 21%
CBU shipments by country of destination (n= 271)
France United States United Kingdom Italy Israel The Netherlands Germany Colombia Greece Australia Turkey Argentina Canada Denmark Hungary Mexico Belgium Cuba Portugal Switzerland Austria Chile Finland Poland Sweden
80 70 60 50 40 30 20 10 0