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ANNUAL REPORT 2010

REDMO


VOLUNTEER DONORS Available typed donors on December 31st 2010

86 361 â–˛ 8%

100000 90000 80000 70000 60000 50000 40000 30000 20000 10000 0 1994

1996

1998

2000

2002

„ Registered donors

2004

2006

2008

2010

Donors typed in 2010: 8 175

Current age of available typed donors 4000 3500 3000 2500 2000 1500 1000 500 0 18

20

22

24

26

Mean donor age: 42.6 years Standard deviation: +/- 9.8

28

30

32

34

36

38

40

42

44

46

48

Median age of donors: 42.2 years

50

52

54


VOLUNTEER DONORS

Donors per Autonomous Community Autonomy

Typed 2010

Total Actives

x 100 000 inh

1 545

14 001

167.25

Aragón

29

1 105

82.03

Asturias

91

2 156

198.83

Baleares (Islas)

157

1 612

145.74

Canarias

710

4 791

226.15

Cantabria

63

537

90.67

Castilla y León

528

5 644

220.51

Castilla – La Mancha

206

2 415

115.09

Catalunya

1 068

14 189

188.89

Comunidad Valenciana

1 821

9 381

183.52

Extremadura

145

3 154

284.85

Galicia

172

2 122

75.85

Madrid (Comunidad de)

649

8 982

139.07

Murcia (Región de)

279

5 944

406.57

Navarra (Comunidad Foral de)

471

5 677

891.31

País Vasco

144

3 770

173.07

Rioja (La)

80

600

186.10

Ciudad Autónoma de Ceuta

14

108

134.03

Ciudad Autónoma de Melilla

1

40

52.61

Andorra

2

133

158.18

8 175

86 361

176.97

Andalucía

Total


VOLUNTEER DONORS Registered volunteer donors per 1 000 inhabitants 160 140 120 100 80 60 40 20 0

Donors cancelled during 2010

2 145

Donors cancellation reasons Over 55 years

1 840

Disease

94

Untraceable

88

Voluntary withdrawal

46

Effective peripheral blood donation

32

Death

16

Ethical

15

Transferred to other registries

8

Other reasons

6


VOLUNTEER DONORS

Effective donations of haematopoietic stem cells during 2010

39

Per product Bone Marrow

6 (16%)

Periphera blood stem cells

32 (84%)

Lymphocytes

1 Collection Centres BM / PBSC / DLI

Hospital

BM

PBSC

DLI

Total

Hospital Virgen de la Arrixaca

0

3

0

3

Hospital Gregorio Marañón

0

2

0

2

Hospital Clínic de Barcelona

1

2

0

3

Centre de Transfusió i Banc de Teixits

0

4

0

4

Hospital de Donostia

1

3

0

4

Hospital Carlos Haya

1

1

0

2

Hospital Clínico de Salamanca

0

1

0

1

Hospital de la Princesa

1

3

1

5

Hospital Dr. Negrín

1

5

0

6

Fundación Jiménez Díaz

0

1

0

1

Hospital Son Espases

0

1

0

1

Hospital Puerta de Hierro

0

1

0

1

Hospital Ramón y Cajal

1

2

0

3

Hospital Central de Asturias

0

1

0

1

Complexo Hospitalario Univ. A Coruña

0

1

0

1

Hospital La Paz

0

1

0

1

Total

6

32

1

39


UMBILICAL CORD BLOOD Available cord blood units on December 2010

47 324 ▲ 13%

50000 45000 40000 35000 30000 25000 20000 15000 10000 5000 0 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010

„ Available cord blood units

Cord Blood Units 2010: 5 767

Avaible Cord Blood Units per 1 000 inhabitants 3,5 3 2,5 2 1,5 1 0,5 0


UMBILICAL CORD BLOOD Cord Blood Units – Cord Blood Banks distribution Bank

Number

TNC

CD34+

> 1 x109

available

Málaga Castilla – La Mancha: 598; Murcia: 1

17 672

50%

69%

Barcelona Navarra: 764; Extremadura: 303; Aragón: 322; Baleares: 204; Cantabria: 94

13 779

71%

100%

Madrid La Rioja: 27

5 617

59%

89%

Galicia Castilla y León: 162; Asturias: 18

5 434

34%

98%

Valencia

4 140

57%

100%

Tenerife

455

34%

26%

País Vasco

186

100%

100%

39

33 %

100%

2

50%

100%

Vidacord Ivida 18000 16000 14000 12000 10000 8000 6000 4000 2000 0

„ Total

„ CD34+ available

„ TNC > 1x10^9


UMBILICAL CORD BLOOD Spanish Cord Blood Units provided during 2010

343

By originating banks Originating Bank

National patients

Foreign patients

Total

60 (41)

175 (101)

235 (142)

Málaga

7 (3)

45 (28)

52 (31)

Madrid

2 (9)

19 (17)

21 (26)

Valencia

3 (3)

16 (12)

19 (15)

Galicia

0 (0)

15 (13)

15 (13)

Tenerife

0 (0)

1 (2)

1(2)

País Vasco

0

0

0

Vidacord

0

0

0

Ivida

0

0

0

Total

72

271

343

Barcelona

Cord blood units provided by cord blood bank 250 200 150 100 50 0 2007 Barcelona

2008 Málaga

Madrid

2009 Valencia

2010 Galicia

Tenerife


Cumulative incidence of spanish donations

1800 1600 1400 1200 1000 800 600 400 200 0 1994

1996

1998

2000

2002

2004

2006

2008

Total donations*: 1 721 „ CBU (n= 1 332) [343] * DLI donations not included [2010 total activity]

„ PBSC (n= 230) [32]

„ BM (n= 159) [6]

2010


NATIONAL PATIENTS A. Searches started Searches started during 2010

768 ▲12%

Type of search Bone marrow / Peripheral blood

224 (29%)

Cord blood

13 (2%)

Bone marrow / Peripheral blood and Cord blood

531 (69%)

Search evolution for national patients

800 700 600 500 400 300 200 100 0 1992

1994

1996

1998

2000

2002

2004

2006

2008

2010

Searches started 2010: 768

■ CBU (n= 13)

„ PBSC / BM + CBU (n= 531)

„ PBSC / BM (n= 224)


NATIONAL PATIENTS

Searches started by community of residence of patient (n= 768) Autonomous Community

Number

x 100 000 inh

Andalucía

91

1.09

Aragón

10

0.74

Asturias

37

3.41

Baleares (Islas)

11

0.99

Canarias

21

0.99

Cantabria

24

4.05

Castilla y León

52

2.03

Castilla – La Mancha

15

0.71

163

2.17

Comunidad Valenciana

79

1.54

Extremadura

15

1.35

Galicia

53

1.89

Madrid (Comunidad de)

94

1.45

Murcia (Región de)

25

1.71

Navarra (Comunidad Foral de)

17

2.67

País Vasco

42

1.93

Rioja (La)

9

2.79

Ciudad Autónoma de Ceuta

1

1.24

Ciudad Autónoma de Melilla

0

0

Foreign

9

NA

Catalunya


NATIONAL PATIENTS

Searches started by diagnosis (n= 768) Acute Myeloblastic Leukaemia

213

Acute Lymphoblastic Leukaemia

127

Myelodysplastic disorders

83

Non-Hodgkin ‘sLymphoma

68

Other leukaemias

51

Hodgkin’s Lymphoma

47

Monoclonal gammopathy

44

Inherited erythrocytic abnormality

29

Severe aplastic anaemia

28

Chronic myeloid leukaemia

27

Other malignant disease

15

Inherited metabolic disease

13

Inherited Immune system disease

10

Histiocytosis

8

Other non malignant disease

5


NATIONAL PATIENTS Evolution of searches by main diagnoses

250

200

150

100

50

0 2002

2003

ALL

2004 AML

2005

2006

CML

2007

MDS

2008

2009

Lymphomas

2010

Cong. Dis.

Evolution of the mean age of searches 40

37 years 35

37 33

30 30 25

20

25 23

26

27

34

31

28

24

21

15 1998

2000

2002

2004

2006

2008

2010


NATIONAL PATIENTS

CBU selections made by the REDMO Office during 2010

164

Active searches on January 1st 2010

251

Active searches on December 31st 2010

268

Cancelled searches during 2010

764

Cancellation reasons Unrelated transplantion

404

National regulation (see detail*)

134

Death

124

Clinical Status

56

Related transplantion

12

Patient decision

12

Unrelated DLI infusion

9

Other (typing’s change, other therapy, transfer to other registries)

8

Autologous transplant

5

* Details of the searches cancelled due to national regulations Inactive searches for >1 year (without donor )

10

Inactive searches for >1 year (with donor )

77

Searches that have remained active 2 years

8

Searches that have remained active 1 year

39


NATIONAL PATIENTS

Inactive searches on December 31, 2010

203

Reason for inactive searches Suitable donor found Selected cord blood unit (infusion pending)

194 9

B. Localized donors Patients for whom one or more donors have bee located (BM / PBSC) Donors located during 2010 (BM / PBSC) Time to find the first BM / PBSC donor mean (days) Time to find the first BM / PBSC donor median (days)

477 â–˛10% 806 80 (SD: Âą 94) 48

Search time for BM / PBSC donors in percentages Before 3 months

79.9

Between 3 and 6 months

10.9

Between 7 and 9 months

4.8

Between 10 and 12 months

1.7

More than 12 months

2.7


NATIONAL PATIENTS Evolution of donors localized 800 700 600 500 400 300 200 100 0 1994

1996

1998

2000

2002

2004

2006

2008

2010

Donors found in 2010: 806

Median time to locate the first BM / PBSC donor 200 180 160 140 120 100 80

48 days

60 40 20 0 1996

1998

2000

2002

2004

2006

2008

2010


NATIONAL PATIENTS

Actuarial probability of locating a donor with 7/8 or 8/8 identities

1

2009

2008 2007

Probability of donor 7/8 or 8/8

0.8

2006 2010

0.6

0.4

Searches started in 2008-2010: 2006 Probability of donor 3 months = 52% 6 months = 64% 9 months = 69% 12 months = 72%

0.2

0 0

3

6

9

12

15

18

21

Months of search

24

27

30

33

36


NATIONAL PATIENTS C. Transplants Haematopoietic transplantions performed during 2010

404 ▲13%

By product Bone Marrow

83 (21%)

Peripheral blood setm cells

179 (44%)

Cord blood unit

142* (35%)

(lymphocytes infusion)

(9)

(*9 transplant performed with double cord)

Evolution of performed transplants 400 350 300 250 200 150 100 50 0 1994

1996

1998

2000

2002

2004

2006

2008

Transplant perfomed 2010: 404

■ CBU (n= 142)

„ PBSC (n= 179)

„ BM (n= 83)

2010


NATIONAL PATIENTS Transplant by country of origin BM / PBSC (n= 262) Germany

141

United States

67

United Kingdom

14

Spain

11

Portugal

8

France

6

Italy

5

Israel

2

Switzerland

2

Australia

1

Canada

1

Cyprus

1

Denmark

1

The Netherlands

1

Norway

1 Transplant by country of origin CBU* (n=142)

Spain

73

United States

54

Germany

9

Australia

6

France

5

Switzerland

2

Italy

1

Sweden

1

(* 9 double cord transplantation)


NATIONAL PATIENTS Actuarial probability of matching donor and transplantion

1 3018 searches started in 2006-2010 Probability of compatible donor

0,8

Probability

0,6

Probability of HSCT (with donor or cord blood)

0,4 Probability of HSCT (with a donor)

0,2

0 0

3

6

9

12

15

18

21

Months

24

27

30

33

36

39


NATIONALPATIENTS Transplants performed by Autonomous Community (2010) Baleares; 1; 0% Asturias; 15; 4% P. Vasco; 5; 1% Galicia; 27; 7%

Valencia; 58; 14%

Navarra; 7; 2% Andalucia; 55; 14%

Cantabria; 28; 7%

Castilla y León; 30; 7%

Murcia; 14; 3%

Madrid; 63; 16%

Catalunya; 101; 25%

Activity by Autonomous Comunity 120 100 80 60 40 20 0

„ Total trasplants

„ Transplant from same community


NATIONAL PATIENTS Summary REDMO activity (national patients)

7000 6000 5000 4000 3000 2000 1000 0

Started searches 1st donor located (BM/PBSC and CBU) (n=4796) Transplants (n=2668)


FOREIGN PATIENTS

Preliminary searches

16 654 ▲ 9%

Activated searches

1 230

Evolution of searches for foreign patients 20000 18000 16000 14000 12000 10000 8000 6000 4000 2000 0 1994

1996

1998

„ Preliminary Searches (n= 16 654)

2000

2002

2004

2006

2008

„ Activated searches (n=1 230)

2010


FOREIGN PATIENTS Requested tests

2 026

Performed tests

1 605

Evolution of performed tests 1800 1600 1400 1200 1000 800 600 400 200 0 2003

2004

2005

2006

2007

2008

2009

2010


FOREIGN PATIENTS

Haematopoietic stem cells transplant performed 2010

299

Transplants by product Bone marrow

2 (1%)

Peripheral blood stem cells

26 (9%)

Umbilical cord blood*

271 (90%)

(lymphocyte infusion)

(1)

* This corresponds to UCB units shipped. There is not confirmation of infusion in all cases.

Transplant by country of destination BM / PBSC (n= 28) Germany

10

France

6

United States

5

Argentina

1

Australia

1

Belgium

1

The Netherlands

1

Ireland

1

Portugal

1

United Kingdom

1


FOREIGN PATIENTS UCB shipments by country of destination (n= 271) France

67

United States

63

United Kingdom

34

Italy

21

Israel

11

The Netherlands

10

Germany

9

Colombia

8

Greece

8

Australia

5

Turkey

5

Argentina

4

Canada

3

Denmark

3

Hungary

3

Mexico

3

Belgium

2

Cuba

2

Portugal

2

Switzerland

2

Austria

1

Chile

1

Finland

1

Poland

1

Sweden

1

Uruguay

1


FOREIGN PATIENTS Transplant by country of destination BM / PBSC (n= 28)

Netherland 4%

Ireland  4%

Portugal 4%

United Kingdom 4%

Belgium  3% Australia  3% Argentina  3%

Germany 36%

United States 18% France  21%

CBU shipments by country of destination (n= 271)

France United States United Kingdom Italy Israel The Netherlands Germany Colombia Greece Australia Turkey Argentina Canada Denmark Hungary Mexico Belgium Cuba Portugal Switzerland Austria Chile Finland Poland Sweden

80 70 60 50 40 30 20 10 0


Annual Report 2010 - REDMO