New Emerging Therapies for Obesity and Weight Loss

Audience Question #1

What is the best piece of advice you have ever been given pertaining to your weight?

Audience Question #2

What is considered the biggest health risk factor?

1. Smoking

2. Hypertension

3. Physical Inactivity

4. Obesity

5. Age

Obesity Facts 2022

Prevalence of Obesity

U.S. adults ages 20-65 years from the National Health and Nutrition Examination Survey

1999 - 2014

https://www.nature.com/articles/s41387-018-0024-2/figures/1

Cardiometabolic Health Trends in the U.S.

Study assessed obesity, blood glucose, blood lipids, blood pressure, and clinical CVD.

In 2017 – 2018 only 6.8% of U.S. adults had optimal cardiometabolic health. (Decreased from 12% in 1999 - 2000)

https://www.sciencedirect.com/science/article/abs/pii/S0735109722049944?via%3Dihub

From a Physician’s Point of View

Motivating a patient to make Lifestyle Changes

• It’s one thing to ask them to take a pill

• Quite another thing to challenge the way they sleep or exercise or eat.

• The latter are harder to do.

• If the patient can, the data is pointing to a much bigger impact!

Current Therapies for Obesity

Most common medications approved by FDA for treatment of obesity include:

• Bupropion-naltrexone (Contrave, Mysimba)

• Liraglutide (Saxenda)

• Orlistat (Alli, Xenical)

• Phentermine-topiramate (Qsymia)

• Lorcaserin (Belviq)

Endoscopic

procedures and weight loss surgeries

Elevated Blood Glucose and Insulin Response

When you eat sugars, refined grains, processed foods:

• Raises blood glucose and resulting insulin response

• Elevated insulin tells your body to turn food into fat to store

• Inhibits burning the fat that you have and you don’t want

• Hyperglycemia is also pro-inflammatory

So Many Nutrition Plan Options!

• We are all very different. No one diet is better for everyone. • Mediterranean, Paleo, Whole 30, Weight Watchers, Keto, Vegetarian –

• All eliminate nutritional stressors and overfeeding

• Choose what works for YOU!

Avoid Sugars

Avoid Refined Grains

Avoid Processed Foods

Those who eat fast food twice a week have twice as much depression!1

1 https://pubmed.ncbi.nlm.nih.gov/21835082/

Tip #2 Target 8 Hours in Bed

Means 6.5 – 7 hours of sleep

• Sleep affects cortisol level

Cortisol level affects hunger • Hunger affects cravings for unhealthy foods

Tip #3 “Cut the Crap”

Eat whole natural foods that are high in fiber and nutrient dense … instead of calorie dense and nutrition poor

Tip #4 Optimize Your Diet

Eat what you like that is healthy

First and most important is to have the desire:

“I want to feel good every day!”

Tip #5 Change Your Default Environment

Don’t want to rely on will power

Example: The worst thing you could eat in your house is a piece of dark chocolate.

GLP-1 Receptor Agonists

Victoza, Saxenda, Bydureon, Trulicity, Ozempic, Wegovy, Mounjaro

ONLY Ozempic, Wegovy, and Mounjaro cross the blood brain barrier.

Diagram credit American Diabetes Association

GLP-1 Receptor Agonists

Victoza, Saxenda, Bydureon, Trulicity, Ozempic, Wegovy, Mounjaro

ONLY Ozempic, Wegovy, and Mounjaro cross the blood brain barrier.

Diagram credit American Diabetes Association

New Enrolling Studies for Overweight and Obese Volunteers

There are additional criteria needed to qualify for these studies.

Because of clinical research, we have new treatments on the horizon!

QUESTIONS?