Table of Contents
Cover image
Title page
Copyright
Dedication
Contributors
Preface
Series editor biography
Acknowledgment
Abbreviations
Chapter 1: Introduction on therapeutic opportunities for autoimmunity
Abstract
1: Introduction
2: From the very first known treatment to the recent developments in therapeutic strategies
3: Conclusion
References
Chapter 2: Innate lymphoid cells as therapeutic targets in autoimmune diseases
Abstract
1: Introduction
2: The biology of innate lymphoid cells
3: Properties and functions of ILCs
4: ILC in autoimmune diseases
5: ILCs as immunoregulators in autoimmune diseases
6: ILC as a potential therapeutic target in autoimmune diseases
7: Future perspectives
8: Conclusion
References
Chapter 3: B regulatory cells in patients with autoimmune diseases: Pathogenic significance and therapeutic potential
Abstract
1: Introduction
2: Identification of Breg cells
3: Functional properties
4: B regulatory cells and autoimmunity: Pathogenic significance
5: Therapeutic potential
6: Conclusion References
Chapter 4: Regulatory T cells in autoimmunity and potential therapeutic targets
Abstract
1: Introduction
2: Discovery of Treg cells
3: Development and activation of Treg cells
4: FoxP3—The transcriptional master regulator of Treg cells
5: Phenotype of Treg cells
6: Treg/T cell subtypes with regulatory function
7: Protocols for estimation of Treg cells in the peripheral blood
8: Isolation of Treg cells for therapeutic purposes
9: Tissue-resident Treg cells
10: Clinical and translational significance of Treg cells
11: Regulatory T cells (Tregs) as potential therapeutic targets
12: Conclusion
References
Chapter 5: Application of IL-6 antagonists in autoimmune disorders
Abstract
1: Introduction
2: Signaling
3: Roles of IL-6
4: IL-6 in ADs and autoimmune-related disorders
5: Laboratory clues
6: IL-6 blockade
7: Conclusion References
Chapter 6: The search for monomer-interaction-based alternative TNF-α therapies
Abstract
1: Introduction
2: TNF-α in relation to stages in life
3: Structure of TNF-α
4: TNF-α therapies
5: Conclusion References
Further reading
Chapter 7: Generation of thymic cells from pluripotent stem cells for basic research and cell therapy
Abstract
Acknowledgments
1: Introduction
2: Thymus organogenesis
3: Thymus function
4: Common thymic disorders
5: Human pluripotent stem cells to TECs: A new frontier
6: Mimicking development in vitro to generate hPSC-derived anterior foregut endoderm
7: Generating thymic epithelial progenitor cells in vitro
8: hPSC-derived thymic epithelial cells
9: In vitro coculture systems to model thymic function
10: Conclusion References
Chapter 8: The NLRP3 inflammasome pathway in autoimmune diseases: a chronotherapeutic perspective?
Abstract
Fundings
1: Introduction
2: The NLRP3 inflammasome
3: NLRP3 and autoimmune diseases
4: The clock and autoimmune diseases
5: NLRP3 as a chronotherapeutic target for autoimmune diseases treatment
6: Conclusion References
Chapter 9: Plasmocyte depletion in autoimmune diseases
Abstract
1: Introduction
2: The plasmocyte
3: New drugs targeting the humoral immunity
4: Drugs in the pipeline
5: Autoimmune diseases that may benefit from plasmocyte targeting
6: Conclusion
References
Chapter 10: Biological aging and autoimmunity
Abstract
1: Introduction
2: Immunosenescence
3: Immune and autoimmune theories of aging
4: Autoimmune diseases, cancer, and their relations with aging
5: Conclusion References
Chapter 11: Efficacy and safety of immune checkpoint inhibitors and cytokine therapy in autoimmune diseases
Abstract
1: Introduction
2: Immunogenicity of mAbs and its effect on efficacy and safety
3: Inflammatory cytokine inhibition in autoimmune diseases
4: ICIs in autoimmune disease
5: Conclusion References
Chapter 12: Nutritional implications for the pathophysiology and treatment of autoimmune disorders
Abstract
1: Introduction
2: Body composition and metabolic health
3: Dietary patterns
4: Macronutrients
5: Micronutrients
6: Additional non-nutrient dietary factors
7: Conclusion
References
Chapter 13: Dysbiosis and probiotic applications in autoimmune diseases
Abstract
1: Introduction
2: Dysbiosis in autoimmune diseases
3: Dysbiosis in autoimmune diabetes
4: Dysbiosis in autoimmune thyroid diseases
5: Dysbiosis in rheumatoid arthritis
6: Dysbiosis in systemic lupus erythematosus
7: Dysbiosis in Sjögren’s syndrome
8: Probiotic applications in autoimmune diseases
9: Probiotics in autoimmune diabetes
10: Probiotics in autoimmune thyroid diseases
11: Probiotics in rheumatoid arthritis
12: Probiotics in systemic lupus erythematous
13: Probiotics in Sjögren’s syndrome
14: Conclusion References
Chapter 14: Precision medicine to manage chronic immune-related conditions
Abstract
Acknowledgments
1: Introduction
2: Immunosenescence
3: Diabetes mellitus
4: Atherosclerotic cardiovascular disease
5: Musculoskeletal conditions and arthritis
6: Mental health conditions
7: Cancer
8: Conclusion
References
Chapter 15: New advanced therapy medicinal products in treatment of autoimmune diseases
Abstract
1: Introduction
2: Autoimmune disorders
3: Conclusion References
Chapter 16: Targeting autoimmune disorders through metal nanoformulation in overcoming the fences of conventional treatment approaches
Abstract
1: Introduction
2: Nanotechnology and nanomaterials
3: Targeting of metal nanoparticles for autoimmune conditions
4: Safety concern of metallic nanoparticles
5: Conclusion
References
Chapter 17: Immunomodulatory effects of parasites on autoimmunity
Abstract
1: Introduction
2: Mechanism of action in helminth therapy
3: Application and protective roles of helminth therapy
4: Current challenges in helminth therapy
5: Animal models for helminth therapy
6: Immunomodulatory roles of parasites on inflammatory or autoimmune diseases
7: Leishmaniasis and autoimmune disorders
8: Toxoplasmosis and autoimmune disorders
9: Conclusion References
Chapter 18: Prediction of autoimmune diseases: From bench to bedside
Abstract
1: Introduction
2: Using genetics to estimate the risk of developing AIDs
3: Epigenetics to predict AIDs
4: Using antibodies and serum biomarkers to predict AIDs
5: Perspectives
6: Prevention
7: Conclusion References Index
Copyright
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Dedication
This book would not have been possible without the continuous encouragement of my family.
I dedicate the book to my daughters, Ariana and Arnika, in the hope that we learn enough from today to make a brighter future for the next generation.
Contributors
Amir Abdoli
Zoonosis Research Center
Department of Parasitology and Mycology, Jahrom University of Medical Sciences, Jahrom, Iran
Catherine J. Andersen
Department of Biology, Fairfield University, Fairfield
Department of Nutritional Sciences, University of Connecticut, Storrs, CT, United States
Alireza Badirzadeh Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Aaqib Zaffar Banday
Allergy and Immunology Unit, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Arsénio Barbosa Department of Internal Medicine, University Hospital Center of São João, Porto, Portugal
Prince Amoah Barnie
The Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University
International Genome Center, Jiangsu University, Zhenjiang, China
Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana
Byron Baron
Centre for Molecular Medicine and Biobanking, University of Malta, Msida, Malta
Cécilia Bellengier
Univ. Lille, U1011 – EGID
Inserm, U1011
CHU Lille
Institut Pasteur de Lille, Lille, France
Anthony J. Bjourson Northern Ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom
Dimitrios P. Bogdanos Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
Tiago Borges Department of Internal Medicine, Trofa Saúde Private Hospital, Vila Nova de Gaia, Portugal
Efthymios Dardiotis Department of Neurology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
Hélène Duez
Univ. Lille, U1011 – EGID
Inserm, U1011
CHU Lille
Institut Pasteur de Lille, Lille, France
Phil Egan Northern Ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom
Reza Falak
Department of Immunology, School of Medicine Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran
Mark Farrugia Centre for Molecular Medicine and Biobanking, University of Malta, Msida, Malta
David S. Gibson Northern Ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom
Julia M. Greco Department of Biology, Fairfield University, Fairfield, CT, United States
Guangran Guo Northern Ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom
Mahdi Habibi-Anbouhi National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
Ensiyeh Hajizadeh-Saffar
Advanced Therapy Medicinal Product Technology Development Center (ATMP-TDC)
Department of Regenerative Medicine
Department of Diabetes, Obesity, and Metabolism, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran
Bertrand Huard TIMC-IMAG Laboratory, CNRS UMR5525, University Grenoble-Alpes, La Tronche, France
Zhila Izadi Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Shahrbanoo Jahangir
Department of Stem Cells and Developmental Biology
Advanced Therapy Medicinal Product Technology Development Center (ATMP-TDC), Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran
Ankur Kumar Jindal
Allergy and Immunology Unit, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Catriona Kelly Northern Ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom
Coral R. Lapsley Northern Ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom
Xia Lin International Genome Center, Jiangsu University, Zhenjiang, China
Chloe A. Martin Northern Ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom
Luísa Sales Martins Microbiology Program, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São Paulo State University (UNESP), São Paulo, Brazil
Kyle B. Matche Northern Ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom
Athanasios Mavropoulos Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
Roisin McAllister Northern Ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom
Paula McClean Northern Ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom
Victoria McGilligan Northern Ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom
Ahmadreza Meamar Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Seyedeh Zohreh Mirjalili
Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Nazanin Mojtabavi
Department of Immunology, School of Medicine Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran
Elaine K. Murray Northern Ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom
Gislane Lelis Vilela de Oliveira
Microbiology Program, Institute of Biosciences, Humanities and Exact Sciences (IBILCE)
Department of Food Engineering and Technology, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São Paulo, Brazil
Benoit Pourcet Univ. Lille, U1011 – EGID
Inserm, U1011
CHU Lille
Institut Pasteur de Lille, Lille, France
Madhulika Pradhan Rungta College of Pharmaceutical Sciences and Research, Bhilai, Chha isgarh, India
Taranjit Singh Rai Northern Ireland Centre for Stratified Medicine, Ulster University, Londonderry, United Kingdom
Stephan Ramos Barbara Davis Center for Diabetes, Department of Pediatrics, School of Medicine, University of Colorado Anschu Medical Campus, Aurora, CO, United States
Nima Rezaei
Research Center for Immunodeficiencies, Children's Medical Center Department of Immunology, School of Medicine, Tehran University of Medical Sciences
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Guilherme Siqueira Pardo Rodrigues Department of Pediatrics, Hospital from School of Medicine from Botucatu (HCFMB), São Paulo State University (UNESP), Botucatu, Brazil
Holger A. Russ Barbara Davis Center for Diabetes, Department of Pediatrics, School of Medicine, University of Colorado Anschu Medical Campus, Aurora, CO, United States
Reyhaneh Sabourian
Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Lazaros I. Sakkas Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
Larissa Vedovato Vilela de Salis Microbiology Program, Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São Paulo State University (UNESP), São Paulo, Brazil
Sérgio Silva Department of Internal Medicine, Trofa Saúde Private Hospital, Vila Nova de Gaia, Portugal
Deependra Singh University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chha isgarh, India
Manju Rawat Singh University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chha isgarh, India
Mustafa Erinç Sitar
Faculty of Medicine, Department of Clinical Biochemistry, Maltepe University
Maltepe University Experimental Animals Application and Research Center, Istanbul, Turkey
Nathalie Sturm
Department of Pathology, University Hospital, Grenoble
TIMC-IMAG Laboratory, CNRS UMR5525, University GrenobleAlpes, La Tronche, France
Gabriel J. Tobón Universidad Icesi, CIRAT: Centro de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Cali, Colombia
Rahul Tyagi Allergy and Immunology Unit, Department of Pediatrics, Advanced Pediatric Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Álvaro J. Vivas
Universidad Icesi, Facultad de Ciencias de la Salud, Calle 18 No. 122 -135
Universidad Icesi, CIRAT: Centro de Investigación en Reumatología, Autoinmunidad y Medicina Traslacional, Cali, Colombia
Krishna Yadav University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, Chha isgarh, India
Niloufar Yazdanpanah Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
Efterpi Zafiriou Department of Dermatology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece
Sareh Zeydabadinejad Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Su Zhaoliang
The Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University
International Genome Center, Jiangsu University, Zhenjiang, China
