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NUTRACEUTICALS

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NUTRACEUTICALS Nanotechnology

in the Agri-Food Industry,

Volume 4

ALEXANDRU MIHAI GRUMEZESCU

Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, Romania

AMSTERDAM • BOSTON • HEIDELBERG • LONDON • NEW

PARIS • SAN DIEGO • SAN

Academic Press is an imprint of Elsevier

Academic Press is an imprint of Elsevier

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Copyright © 2016 Elsevier Inc. All rights reserved.

No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions.

This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).

Notices

Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.

Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.

To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.

British Library Cataloguing-in-Publication Data

A catalogue record for this book is available from the British Library

Library of Congress Cataloging-in-Publication Data

A catalog record for this book is available from the Library of Congress

ISBN: 978-0-12-804305-9

For information on all Academic Press publications visit our website at https://www.elsevier.com/

Publisher: Nikki Levy

Acquisition Editor: Patricia Osborn

Editorial Project Manager: Karen Miller

Production Project Manager: Caroline Johnson

Designer: Mark Rogers

Typeset by Thomson Digital

LIST OF CONTRIBUTORS

Asif Ahmad

PirMehr Ali Shah Arid Agriculture University, Department of Food Technology, Rawalpindi, Pakistan

Zaheer Ahmed

AllamaIqbal Open University Islamabad, Department of Home and Health Sciences, Islamabad, Pakistan

Biljana Arsic

University of Nis, Department of Mathematics, Faculty of Sciences and Mathematics, Nis, Republic of Serbia

Ali Asghar

University of Agriculture, National Institute of Food Science and Technology, Faisalabad, Pakistan; A’Sharqiyah University, Department of Food Science and Human Nutrition, Ibra, Sultanate of Oman

Federico Benetti

ECSIN-European Center for the Sustainable Impact of Nanotechnology, ECAMRICERT srl, Rovigo, Italy

Mahendran Botlagunta

KLEF University, Department of Biotechnology, Biomedical Research Laboratory, Vaddeswaram; Sweety Biologicals India Private Limited, Kavali, Andhra Pradesh, India

Ömer Utku Çopur

Uludag University Faculty of Agriculture, Department of Food Engineering, Bursa, Turkey

Danica Dimitrijevic

University of Nis, Department of Chemistry, Faculty of Sciences and Mathematics, Nis, Republic of Serbia

Anil Kumar Dwivedi

Pharmaceutics Division, CSIR—Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Pankaj Dwivedi

Pharmaceutics Division, CSIR—Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Nancy M. El-Baz

University of Science and Technology (UST), Center for Materials Science, Zewail City of Science and Technology, Giza, Egypt

Ibrahim M. El-Sherbiny

University of Science and Technology (UST), Center for Materials Science, Zewail City of Science and Technology, Giza, Egypt

Hele Everaus

University of Tartu, Department of Hematology and Oncology, Tartu, Estonia

Joana F. Fangueiro

University of Trás-os-Montes e Alto Douro, Quinta de Prados, Centre for Research and Technology of Agro-Environmental and Biological Sciences, CITAB, Vila Real, Portugal

Milen Georgiev

Laboratory of Applied Biotechnologies, Institute of Microbiology, Bulgarian Academy of Sciences, Plovdiv, Bulgaria

Mahua Ghosh

University of Calcutta, Department of Chemical Technology, Kolkata, West Bengal, India

Tapan Kumar Giri

NSHM College of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata Group of Institutions, Kolkata, West Bengal, India

Aswathy Ravindran Girija

Toyo University, Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Kawagoe, Saitama, Japan

Surashree Sen Gupta

University of Calcutta, Department of Chemical Technology, Kolkata, West Bengal, India

Amr Hefnawy

University of Science and Technology (UST), Center for Materials Science, Zewail City of Science and Technology, Giza, Egypt

Abdullah

University of Agriculture, National Institute of Food Science and Technology, Faisalabad, Pakistan

Muhammad Asim Irshad

University of Agriculture, National Institute of Food Science and Technology, Faisalabad, Pakistan

Amita Joshi

B. V. Patel PERD Centre, Department of Pharmaceutics, Ahmedabad, India

Oya Berkay Karaca

University of Cukurova, Karatas School of Tourism and Hotel Management, Adana, Turkey

Khushwinder Kaur

Panjab University, Department of Chemistry and Centre of Advanced Studies in Chemistry, Chandigarh, India

Danijela Kostic

University of Nis, Department of Chemistry, Faculty of Sciences and Mathematics, Nis, Republic of Serbia

D. Sakthi Kumar

Toyo University, Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Kawagoe, Saitama, Japan

Majid Majeed

University of Agriculture, National Institute of Food Science and Technology, Faisalabad, Pakistan

Laura Manodori

ECSIN-European Center for the Sustainable Impact of Nanotechnology, Veneto Nanotech S.C.p.A., Rovigo, Italy

Christian Micheletti

ECSIN-European Center for the Sustainable Impact of Nanotechnology, ECAMRICERT srl, Rovigo, Italy

María Encarnación Morales

University of Granada, Department of Technology and Pharmacy, Faculty of Pharmacy, Granada, Spain

Jorge Oliveira

ESAV, Polytechnic Institute of Viseu; Centre for the Study of Education, Technologies and Health’ (CSETH), Polytechnic Institute of Viseu, Viseu, Portugal (CI&DETS)

Celile Aylin Oluk

Eastern Mediterranean Agricultural Research InstituteYuregir, Adana, Turkey

Ilkay Erdogan Orhan

Gazi University, Department of Pharmacognosy, Faculty of Pharmacy, Ankara, Turkey

Semih Ötles¸

Ege University, Engineering Faculty, Food Engineering Department, Izmir, Turkey

Vandana Patravale

Institute of Chemical technology, Department of Pharmaceutical Science and Technology, Mumbai, India

João P. Pinheiro

University of Coimbra, Physical and Rehabilitation Medicine Department— CHUC, Faculty of Medicine, Coimbra, Portugal

Swati Pund

STES’s Sinhgad Institute of Pharmacy, Department of Pharmaceutics, Pune, India

Ajay Kumar Singh Rawat

Pharmacognosy and Ethnopharmacology Division, CSIR—National Botanical Research Institute, Lucknow, Uttar Pradesh, India

Maria João Reis-Lima

ESAV, Polytechnic Institute of Viseu; Centre for the Study of Education, Technologies and Health’ (CSETH), Polytechnic Institute of Viseu, Viseu, Portugal (CI&DETS)

María Adolfina Ruiz

University of Granada, Department of Technology and Pharmacy, Faculty of Pharmacy, Granada, Spain

Buket Yalçın S¸ahyar

Ege University, Engineering Faculty, Food Engineering Department, Izmir; Indesit Company household appliances San. ve Tic. INC., Manisa, Turkey

Katrin Sak

University of Tartu, Department of Hematology and Oncology, Tartu, Estonia

Bilge Sener

Gazi University, Department of Pharmacognosy, Faculty of Pharmacy, Ankara, Turkey

Fatma Sezer Senol

Gazi University, Department of Pharmacognosy, Faculty of Pharmacy, Ankara, Turkey

Monika Sharma

Pharmaceutics Division, CSIR—Central Drug Research Institute, Lucknow, Uttar Pradesh, India

Amélia M. Silva

University of Trás-os-Montes e Alto Douro, Quinta de Prados, Centre for Research and Technology of Agro-Environmental and Biological Sciences, CITAB; University of Trás-os Montes e Alto Douro, Department of Biology and Environment, UTAD, Quinta de Prados, Vila Real, Portugal

Krystyna Skalicka-Wozniak

Medical University of Lublin, Department of Pharmacognosy with Medicinal Plant Unit, Lublin, Poland

Eliana B. Souto

University of Coimbra (FFUC), Department of Pharmaceutical Technology, Faculty of Pharmacy, Pólo das Ciências da Saúde, Azinhaga de Santa Comba; University of Coimbra, Center for Neuroscience and Cell Biology & Institute for Biomedical Imaging and Life Sciences (CNC-IBILI), Coimbra, Portugal

Canan Ece Tamer

Uludag University Faculty of Agriculture, Department of Food Engineering, Bursa, Turkey

Edite Teixeira-Lemos

ESAV, Polytechnic Institute of Viseu; Centre for the Study of Education, Technologies and Health’ (CSETH), Polytechnic Institute of Viseu, Viseu, Portugal (CI&DETS)

Luís Pedro Teixeira-Lemos

University of Coimbra, Faculty of Medicine, Coimbra, Portugal

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SERIES FOREWORD

The emergence of nanotechnology has reached impressive heights in recent years and the development of special nanodevices and nanomaterials has found intriguing applications in agriculture and food sector. Most of the investigated nanotechnological approaches initially aimed to solve evolving problems in the agrifood industry in order to impact on the economic potential. Soon after the implementation of new technologies and approaches that were using nanostructured materials, the worldwide concern was rapidly extended to numerous applications that could be developed by using the science of nanosized materials. Smart materials, biosensors, packaging materials, nutraceuticals, and nanodevices have been designed to address numerous agri-food related issues with direct impact in health, economy, ecology, and industry. As the engineering of nanostructures has constantly progressed and extended its applications, there is virtually unlimited potential in this sector. However, the widely differing opinions on the applicability and usefulness of nanotechnology between both specialists and the general public has hampered progress. The main concern manifested by people is related to the potential risk for health and the environmental impact of the recently developed nanoengineered materials and devices. Therefore, current approaches are strictly considering these concerns when designing nanotechnological solutions for agriculture and food sectors.

This multivolume series was developed by the constant need to discover current inquiries and approaches on the field of agrifood science and also to learn about the most recent progress, approaches, and applications that have emerged through nanotechnology.

As agriculture is the backbone of most developing countries, nanotechnology has the potential to revolutionize the agriculture and food sector by promoting productivity through genetic improvement of plant and animal foods. It can also ensure the delivery of drugs, genes, and pesticides to specific sites at cellular levels in targeted plants and animals, by limiting side effects. Nanotechnology can be used to evaluate gene expression under different stress condition for both plant and animal foods through the development of nanoarray-based gene-technologies. Additionally, this technology can detect fertilizers, pesticides with high precision by smart nanosenors for an adequate management of the natural resources. Moreover, numerous industrial-related applications with direct impact on economy have emerged. For example,

nano- and micro-structured arrays can detect the early presence of pathogens, contaminants, and food spoilage factors. Other applications for this technology are smart integration systems for food processing and packaging, as well as nanoemulsion-based decontaminants for food equipment and storage compartments, and nanoparticles that facilitate the bioavailability and delivery of nutrients directly to cells.

The potential benefits of nanotechnology for agriculture, food, fisheries, and aquaculture were identified and supported by many countries, which invested a significant amount of money in the development of applications. Also, numerous campaigns are currently trying to increase awareness on the developing process and recent technologies in order to influence the acceptance of customers. Although nanoagri-food industrialized concept could help to find a sustainable solution for the current global food crisis, the offered advantages should balance the concerns regarding soil, water, environment, and health related issues that such approach could bring.

The series entitled Nanotechnology in the Agri-Food Industry brings comprehensive and recent knowledge regarding the impact of the science of nanometer-sized materials on the field of agriculture and food industry, but also discuss the current inquiries regarding risks of these applications in all relevant fields such as environment and health, aiming to increase awareness to a wider amount of readers.

Dr Alina Maria Holban Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, Romania

Dr Monica Cartelle Gestal Harvill Lab, University Of Georgia, Athens, GA, United States

SERIES PREFACE

About the Series (Volumes I–X)

In a permanently changing society, health and well being remain the key drivers for the food industry. Despite the technological progress made in the agri-food industry, a true food crisis emerges in several areas of the globe. This can be explained by insufficient food but mostly by inadequate food for a very distinct range of consumers. In this context, innovative technologies represent the core throughout the whole food chain from raw materials/ ingredient sourcing, food processing, quality control of finished products, and packaging. Nanotechnology, coupled with novel interdisciplinary approaches and processing methods, has enabled some important advances recently flourishing in many of these areas. The science of nanosized materials can improve and even resolve the huge challenges faced by the food and bioprocessing industries for developing and implementing systems that can produce qualitative and quantitative foods that are safe, sustainable, environment friendly, and efficient. This emerging tool finds its applications in various fields and represents an endless approach for the development of innovative strategies in food development, processing, and packaging.

This multivolume set aims to bring together the most recent and innovative applications of nanotechnology in the agri-food industry, but also to present the future perspectives in the design of new or alternative foods.

The series contains 200 chapters organized in 10 volumes, prepared by outstanding research groups that made significant impacts on the field of nanotechnology and food-related research sectors. This comprehensive set represents an updated and highly structured material for undergraduate and postgraduate students in food science, biotechnological, engineering fields, but also a valuable resource of recent scientific progress, along with most known applications of nanomaterials on the food industry to be used by researchers, engineers, and academia. Moreover, novel opportunities and ideas for developing or improving technologies in the agri-food industry by innovative companies, biotechnological industries, and other economical structures are highlighted and their potential is widely dissected. This series may be also valuable for the wide audience interested in recent nanotechnological progress in the agri-food field worldwide.

These 10 volumes cover almost all aspects related to the applications of Nanotechnology in the Agri-Food Industry and are named as:

Volume I Novel Approaches

Volume II Encapsulations

Volume III Emulsions

Volume IV Nutraceuticals

Volume V Nutrient Delivery

Volume VI Food Preservation

Volume VII Food Packaging

Volume VIII NanoBioSensors

Volume IX Water Purification

Volume X New Pesticides and Soil Sensors

Each volume contains 20 chapters, which were carefully composed and illustrated to highlight the most innovative and intensively investigated applications of nanotechnology on particular wide interest domains of the agri-food industry field.

Alexandru Mihai Grumezescu

University Politehnica of Bucharest, Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Bucharest, Romania http://grumezescu.com/

VOLUME PREFACE

Nutraceuticals are gaining significant attention due to their apparent safety, nutritional, and therapeutic perspectives. Scientific indications have reinforced dietary interposition as an effective implement for a healthy life style. Various bioactive components have been reported to exhibit antioxidant, antiinflammatory, antimicrobial, hypocholesterolemic, hypoglycemic, antimutagenic, and anticarcinogenic roles in the living systems. Regardless of the effectiveness of bioactive components, their applications in the food and pharmaceutical industry are limited due to poor bioavailability, storage, heat instability, and insolubility in aqueous medium. During storage, essential bioactive components are lost quickly as a result of volatilization, chemical degradation, and certain other physical and chemical reactions. Nanotechnology is one of the most interesting areas concerned with consumer products including electronics, cosmetics, household appliances, textiles, and food production as well as in various medical products. Although the applications of nanoscale particles in the development of therapeutic systems have been well documented and various systems have been designed for intelligent, modulated, and selective delivery of drugs to specific areas in the body in order to maximize drug action and minimize side effects, nanotechniques are relatively new in the food industry. Various natural or synthetic polymer-based nanoparticulate systems and their conjugates are potentially available to the food industry; it includes proteins, lipids, carbohydrates, or other biopolymers. Furthermore, direct nanoparticle uptake is controlled by the size and surface chemistry of the nano system. The use of this direct nanoparticle uptake, in particular for soluble but poorly absorbed ingredients, is one of the areas that needs to be explored in the future, as well as the potential side effects of these nanoparticle carriers. To address this challenge, it is necessary to understand the chemical structure and properties of different nutraceuticals. Based on the scope of nanotechnology in the development of nutraceuticals, this book describes the potential role and impact of nutraceutical delivery systems in food industry. Volume IV contains 20 chapters, prepared by outstanding international researchers from Bulgaria, Egypt, Estonia, India, Italy, Japan, Oman, Pakistan, Poland, Portugal, Serbia, Spain, and Turkey.

In Chapter 1, Mineral and Vitamin Fortification, Biljana Arsic et al. present an up-to-date review regarding mineral and vitamin

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