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SECOND EDITION

HALL | COCKERELL

CHISHOLM • JESSUP • VANDERGRIFF

MOTAPARTHI • ELSTON

SECOND EDITION

Brian J. Hall, MD

Dermatopathologist

Utah Pathology Services, Inc.

Adjunct Assistant Professor, Department of Pathology

University of Utah School of Medicine Salt Lake City, Utah

Clay J. Cockerell, MD

Clinical Professor of Dermatology and Pathology

Director, Division of Dermatopathology

University of Texas Southwestern Medical Center Dallas, Texas

Cary Chisholm, MD

Dermatopathologist

Central Texas Pathology Laboratory Waco, Texas

Chad Jessup, MD, MS Instructor

Department of Dermatology

Massachusetts General Hospital Boston, Massachusetts

Travis Vandergriff, MD

Assistant Professor of Dermatology and Pathology

University of Texas Southwestern Medical Center Dallas, Texas

Kiran Motaparthi, MD

Assistant Professor

Department of Dermatology

University of Florida College of Medicine

Gainesville, Florida

Dirk M. Elston, MD

Professor and Chairman

Department of Dermatology and Dermatologic Surgery

Medical University of South Carolina Charleston, South Carolina

1600 John F. Kennedy Blvd.

Ste 1800 Philadelphia, PA 19103-2899

DIAGNOSTIC PATHOLOGY: NONNEOPLASTIC DERMATOPATHOLOGY, SECOND EDITION

Copyright © 2017 by Elsevier. All rights reserved.

ISBN: 978-0-323-37713-3

No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/ permissions.

This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).

Notices

Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.

Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.

With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions.

To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.

Publisher Cataloging-in-Publication Data

Names: Hall, Brian J. (Brian John), 1981-

Title: Diagnostic pathology. Nonneoplastic dermatopathology / [edited by] Brian J. Hall

Other titles: Nonneoplastic dermatopathology. Description: Second edition. | Salt Lake City, UT : Elsevier, Inc., [2016] | Includes bibliographical references and index.

Identifiers: ISBN 978-0-323-37713-3

Subjects: LCSH: Skin--Diseases--Diagnosis--Handbooks, manuals, etc. | MESH: Skin Diseases--pathology--Atlases. | Skin Diseases--diagnosis--Atlases.

Classification: LCC RL105.D53 2016 | NLM WR 17 | DDC 616.5’075--dc23

International Standard Book Number: 978-0-323-37713-3

Cover Designer: Tom M. Olson, BA

Printed in Canada by Friesens, Altona, Manitoba, Canada

Last digit is the print number: 9 8 7 6 5 4 3 2 1

Dedications

To my wife, Jamie, our Great Dane, Sadie, and all the wonderful, bright, hard-working, and dedicated authors who I have gotten to know over the years and have the pleasure of considering my close friends. I also want to thank all the contributors as well as authors for their selfless giving of images for chapters that were not their own. This book would not be possible without everyone listed in the table of contents as well as on the contributors page.

BJH

To my wife, Brenda, and children, Charlie and Lily, who have supported me so much in my life and in my career.

CJC

To my wife and kids, thank you for your unwavering love and support. For all the other contributors, thank you for your hard work and dedication to produce such a high-quality dermatopathology text. To me, Brian, and Travis: Strong work you rugged, chiseled gentlemen.

CC

I would like to thank my incredibly loving and supportive wife, Clarissa, whose sacrifices have allowed me to work on this book. Equally as important, I would like to dedicate this endeavor to her, my sons, Carter and Clark, as well as the memory of my late parents, Don and Joyce.

CJ

To my mentors and colleagues, who teach me, and to my patients, who inspire me to keep learning.

TV

Contributing Authors

Patricia J. Alvarez, MD

Dermatologist and Dermatopathologist

Centro Medico Naval Lima, Peru

Francisco Bravo, MD

Associate Professor of Pathology and Dermatology

Facultad de Medicina Alberto Hurtado

Universidad Peruana Cayetano Heredia Lima, Peru

Tiffany Chen, MD

Research Associate

Department of Dermatology

University of Texas Southwestern Medical Center Dallas, Texas

Wang L. Cheung, MD, PhD

Attending Pathologist Department of Pathology Orlando Health Orlando, Florida

George R. Collins, DO

Dermatopathologist and Cytopathologist

Dominion Pathology Associates Roanoke, Virginia

David J. DiCaudo, MD

Associate Professor

Departments of Dermatology and Laboratory Medicine & Pathology

Mayo Clinic College of Medicine Scottsdale, Arizona

Garth Fraga, MD

Associate Professor of Pathology and Dermatology

University of Kansas School of Medicine

Kansas City, Kansas

Gretchen W. Frieling, MD

Dermatopathologist

Miraca Life Sciences

Newton, Massachusetts

John C. Hall, MD

Dermatologist

St. Luke’s Hospital Associate Staff

University of Missouri Kansas City Medical School

Kansas City Free Health Clinic

Kansas City, Missouri

Fatima A. Khan, MD Medical Resident

Department of Internal Medicine

Texas Health Resources

Dallas Presbyterian Hospital Dallas, Texas

Christine J. Ko, MD

Professor of Dermatology and Pathology

Yale University

New Haven, Connecticut

Martin C. Mihm, Jr., MD

Professor of Pathology and Dermatology

Harvard Medical School

Director of Melanoma Program, Dermatology

Brigham and Women’s Hospital

Co-Director of Melanoma Program

Dana-Farber and Brigham and Women’s Cancer Center Boston, Massachusetts

Annie O. Morrison, MD

Dermatopathology Fellow

Department of Dermatology

University of Texas Southwestern Medical Center

Cockerell Dermatopathology Dallas, Texas

Christie Riemer, BS

MS4 (4th Year Medical Student)

Michigan State University College of Human Medicine

Grand Rapids, Michigan

Bruce R. Smoller, MD

Professor and Chair, Department of Pathology

Professor, Department of Dermatology

University of Rochester School of Medicine and Dentistry

Rochester, New York

Joseph Susa, DO

Fellowship Program Director

Department of Dermatology

University of Texas Southwestern Medical Center Dallas, Texas

Connie V. Tran, BA Medical Student

Texas A&M University, College of Medicine Bryan, Texas

Andrew Walls, MD

Dermatology Resident

Harvard Combined Dermatology Residency Boston, Massachusetts

Talley Whang, MD

Dermatologist and Dermatopathologist

Dermatology Center of Southern Indiana

Bloomington, Indiana

Volunteer Faculty

Indiana University School of Medicine

Indianapolis, Indiana

Additional Contributors

Malak Abedalthagafi, MD

Kajsa Affolter, MD

David S. Cassarino, MD, PhD

Jessica M. Comstock, MD

Gonzalo De Toro, MD

Senait Dyson, MD

Carly A. Elston, MD

Tammie Ferringer, MD

Larissa V. Furtado, MD

Sudeep Gaudi, MD

L. David Hall, MD

Julie E. Jackson, MD

Michelle Lucero Jackson, MD

Sharon Jacob, MD

Dražen M. Jukić, MD, PhD

Atsuko Kodama, MD

Irina Margaritescu, MD, DipRCPath

Danny A. Milner, Jr., MD, MSc

Elizabeth A. Montgomery, MD

Cornelia S. L. Müller, MD

Susan Müller, DMD, MS

Khang Nguyen, MS

Michael W. Peterson, DO

Eleanor Russell-Goldman, MD, PhD

Chandra N. Smart, MD

Emma Taylor, MD

Viseslav Tonkovic-Capin, MD

Diane L. Wang, BSc

Noelle Williams, MD

Aparche Yang, MD

Image Contributors

Nnenna Agim, MD

Richard J. Antaya, MD

Steven Billings, MD

Jyotirmay Biswas, MD

Anneli R. Bowen, MD

Lisa Mask Bull, MD

Romana Ceovic, MD, PhD

Marsha L. Chaffins, MD

Joanna Chan, MD

Stephanie Chan, MD

Melvin Chiu, MD, MPH

Cheryl Coffin, MD

Lisa M. Cohen, MD

Jaime Cok, MD

Landon W. Coleman, MD

Joseph D. Conlon, MD

Mariana C. Costa, MD

Abdul Hafeez Diwan, MD, PhD

Sunil Dogra, MD

Arturo Dominguez, MD

Keith L. Duffy, MD

Senait W. Dyson, MD

Aleksander Dzamic, MD

Gary L. Ellis, DDS

Jürgen Ervens, MD, DMD

Sebastien de Feraudy, MD

Scott R. Florell, MD

Nima Gharavi, MD, PhD

Analisa V. Halpern, MD

Ronald M. Harris, MD, MPH

Paul B. Hillesheim, DO

Sylvia Hsu, MD

Kathie Huang, MD

H. Ray Jalian, MD

Richard Allen Johnson, MD

David Kaplan, MD

Thelda Kestenbaum, MD

Kevin Kia, MD

Erik W. Kraus, MD

Zelika Kumakawa, MD

Lester J. Layfield, MD

Philip E. LeBoit, MD

Kristin M. Leiferman, MD

Evelyn Lilly, MD

Peter A. Lio, MD

Adam D. Lipworth, MD

Daniel S. Loo, MD

Bhushan Madke, MBBS, MD

Mac Mahan, MD

Brian M. Matthys, DO

Timothy H. McCalmont, MD

Amy McClung, MD

Martha McCollough, MD

Samuel L. Moschella, MD

Thaddeus W. Mully, MD

Rosalynn M. Nazarian, MD

Elan M. Newman, MD

Amy Jo Nopper, MD

Amit Pandya, MD

Karen Paucar, MD

Howard Pride, MD

Bobbi Pritt, MD, MSc, DTMH

Yousuf Qureshi, MD

Cesar Ramos, MD

Marcia Ramos-e-Silva, MD, PhD

Scott M. Ravis, MD

Charles Rhoades, MD

Deanne Mraz Robinson, MD

Cecilia M. Rosales, MD

Ilana Rosman, MD

Beth S. Ruben, MD

Cesar Salinas, MD

Peter Sarantopoulos, MD

David M. Scollard, MD, PhD

Harleen K. Sidhu, MD

Theresa Sofarelli, PA-C

Paul M. Southern, Jr., MD, DTMH

Carole Stanford, MD

James W. Steger, MD

Gabriela Strauch, MD

Ki-Young Suh, MD

Amanda Tauscher, MD

Lester D. R. Thompson, MD

Michele Thompson, MD

Sheryll L. Vanderhooft, MD

Richard Wang, MD, PhD

Kalman Watsky, MD

Lindsay Wilson, MD

Sook-Bin Woo, DMD, MMSc

Scott Worswick, MD

John M. Wright, DDS, MS

Jashin Wu, MD

Clarissa Yang, MD

Holly Zhou, MD

Preface

Nonneoplastic dermatopathology is sometimes seen as one of the most difficult parts of pathology residency training, and it can represent a very confusing subject for the general pathologist who does not see these types of cases on a regular basis. Part of the difficulty is due to the importance of clinical correlation. Although important in all of medicine, clinicopathologic correlation may be most important in nonneoplastic dermatopathology, as clinically striking lesions can have near normal histologic findings, and prominent histologic changes may lead to less than impressive clinical manifestations. Moreover, many clinical entities are not often seen or taught outside of a specific rotation in dermatology or dermatopathology.

Diagnostic Pathology: Nonneoplastic Dermatopathology, Second Edition therefore includes clinical images of nearly all the entities discussed, 250 in all (with approximately 90 new entities in this second edition). We hope that in-training and practicing pathologists will gain a better understanding of the clinical and histopathologic appearance of these lesions and, more importantly, their major histologic and clinical differential diagnoses.

We also anticipate that dermatologists and dermatopathologists can benefit from this book. Classic histologic images highlight the most important findings, allowing more confident diagnoses and histologic differential diagnoses. This book can also be used as a great study aid for fellows studying for their dermatopathology boards. The quality of the more than 1,500 clinical and histologic images in this book is not easily matched, thanks to the many contributing authors and the work of the image editors at Elsevier.

The book is organized into major histologic reaction patterns &/or disease categories. Within each section, we have attempted to organize entities in order of decreasing frequency usually encountered in general practice. We have also added numerous entities in this second edition in the hopes of producing a more consummate tome.

Our hope is to make the confusing subject of inflammatory dermatopathology much easier to comprehend and master, such that no important diagnoses will be easily overlooked or missed, therefore, improving patient care whether offered by pathologists or dermatologists. The eBook version of this book, Expert Consult, makes Diagnostic Pathology: Nonneoplastic Dermatopathology a comprehensive and easily searchable reference.

Brian J. Hall, MD Dermatopathologist

Utah Pathology Services, Inc.

Adjunct Assistant Professor, Department of Pathology

University of Utah School of Medicine

Salt Lake City, Utah

Acknowledgments

Text Editors

Arthur G. Gelsinger, MA

Nina I. Bennett, BA

Terry W. Ferrell, MS

Karen E. Concannon, MA, PhD

Matt W. Hoecherl, BS

Tricia L. Cannon, BA

Image Editors

Jeffrey J. Marmorstone, BS

Lisa A. M. Steadman, BS

Illustrations

Laura C. Sesto, MA

Lane R. Bennion, MS

Richard Coombs, MS

Art Direction and Design

Tom M. Olson, BA

Laura C. Sesto, MA

Lead Editor

Lisa A. Gervais, BS

Production Coordinators

Angela M. G. Terry, BA

Rebecca L. Hutchinson, BA

Emily Fassett, BA

SECTION 1: Spongiotic and Psoriasiform Dermatoses

SECTION 2: Lichenoid and Vacuolar Interface Dermatoses

SECTION 3: Vesiculobullous Dermatoses

SECTION 4: Vasculitis, Vasculopathy, and Perivascular Dermatoses

SECTION 5: Panniculitides

SECTION 6: Connective Tissue/Soft Tissue Diseases

SECTION 7: Degenerative and Perforating Diseases

SECTION 8: Metabolic/Deposition Diseases

SECTION 9: Mucinoses

SECTION 10: Granulomatous Diseases

SECTION 11: Pilosebaceous Diseases

SECTION 12: Alopecias

SECTION 13: Reactions to Drugs

SECTION 14: Disorders of Epidermal Maturation and Keratinization

SECTION 15: Disorders of Pigmentation

SECTION 16: Neutrophilic Dermatoses

SECTION 17: Nutritional Deficiencies

SECTION 18: Photosensitivity Dermatoses

SECTION 19: Bacterial Infections

SECTION 20: Spirochetal Diseases

SECTION 21: Viral Infections

SECTION 22: Fungal Infections

SECTION 23: Arthropods/Parasites

SECTION 24: Other

TABLE OF CONTENTS

58 LichenSclerosusetAtrophicus

60

WangL.

GeorgeR.Collins,DO,JosephSusa,DO,andClayJ.

Brian

Chad

Brian

Brian

Wang

L.

CaryChisholm,

LichenSimplexChronicus

KhangNguyen,MS,ChadJessup,MD,MS,andMartinC. Mihm,Jr.,MD

PrurigoNodularis

KhangNguyen,MS,ChadJessup,MD,MS,andMartinC. Mihm,Jr.,MD

CaryChisholm,

ChristieRiemer,BS,AnnieO.Morrison,MD,andClayJ. Cockerell,MD

AndrewWalls,MD

LichenPlanus

ChadJessup,MD,MSandMartinC.Mihm,Jr.,MD

50 LichenoidKeratosis

CaryChisholm,MD 52 ErythemaMultiformeandRelatedDisorders

JulieE.Jackson,MDandChandraN.Smart,MD

56 PigmentedPurpuricDermatoses

GonzaloDeToro,MD

ChristineJ.Ko,MD

Graft-vs.-HostDisease

JulieE.Jackson,MDandChandraN.Smart,MD

64 PityriasisLichenoides

JulieE.Jackson,MDandChandraN.Smart,MD

68 PityriasisRubraPilaris

ChristineJ.Ko,MD

70 ErythemaDyschromicumPerstans

72

ChadJessup,MD,MSandMartinC.Mihm,Jr.,MD

LichenStriatus

ChadJessup,MD,MSandMartinC.Mihm,Jr.,MD

74 LichenNitidus

76

ChadJessup,MD,MSandMartinC.Mihm,Jr.,MD

Phytophotodermatitis

KiranMotaparthi,MD

SECTION3:VESICULOBULLOUS DERMATOSES

80 BullousPemphigoid

EmmaTaylor,MD

82 PemphigusandVariants

86

88

92

94

96

98

EmmaTaylor,MD

DermatitisHerpetiformis

ChristineJ.Ko,MD

CicatricialPemphigoid

EmmaTaylor,MD

Hailey-HaileyDisease

ChristineJ.Ko,MD

EpidermolysisBullosaAcquisita

EmmaTaylor,MD

EpidermolysisBullosa(Inherited)

JessicaM.Comstock,MD

LinearIgABullousDermatosis

BrianJ.Hall,MD

100 ErythemaToxicumNeonatorum

JessicaM.Comstock,MD

102 TransientNeonatalPustularMelanosis

104

LarissaV.Furtado,MD

AcropustulosisofInfancy

LarissaV.Furtado,MD

106 PemphigoidGestationis

108

EmmaTaylor,MD

BullousDiabeticorum

ChadJessup,MD,MS

110 PalmoplantarPustulosis

112

AndrewWalls,MD

ErosivePustularDermatosis

CaryChisholm,MD

TABLE OF CONTENTS

114 PorphyriaCutaneaTarda

MichaelW.Peterson,DO,CaryChisholm,MD,andClayJ. Cockerell,MD

SECTION4:VASCULITIS, VASCULOPATHY,ANDPERIVASCULAR DERMATOSES

118 LeukocytoclasticVasculitis

BrianJ.Hall,MD

122 GranulomaFaciale

BrianJ.Hall,MD

124 ErythemaElevatumDiutinum

BrianJ.Hall,MDandGarthFraga,MD

126 UrticariaandVariants

BrianJ.Hall,MD,JohnC.Hall,MD,andGarthFraga,MD

130 ThromboticVasculopathy

BrianJ.Hall,MDandDavidJ.DiCaudo,MD

134 LivedoidVasculopathy

BrianJ.Hall,MDandBruceR.Smoller,MD

136 PolyarteritisNodosa

WangL.Cheung,MD,PhD

138 AnnularErythemas

BrianJ.Hall,MD,DavidJ.DiCaudo,MD,andDirkElston, MD

142 GiantCellArteritis

MichelleLuceroJackson,MD,CaryChisholm,MD,and ClayJ.Cockerell,MD

144 PruriticUrticarialPapulesandPlaquesofPregnancy

BrianJ.Hall,MDandBruceR.Smoller,MD

146 GranulomatosisWithPolyangiitis

BrianJ.Hall,MD

148 Churg-StraussSyndrome

BrianJ.Hall,MDandDirkElston,MD

150 BehçetDisease

BrianJ.Hall,MD,BruceR.Smoller,MD,andDavidJ. DiCaudo,MD

152 MalignantAtrophicPapulosis

BrianJ.Hall,MDandBruceR.Smoller,MD

154 LivedoReticularis

BrianJ.Hall,MDandGarthFraga,MD

156 Thrombophlebitis

MichelleLuceroJackson,MD,CaryChisholm,MD,and ClayJ.Cockerell,MD

158 Pernio

TravisVandergriff,MD

SECTION5:PANNICULITIDES

162 ErythemaNodosum

GretchenW.Frieling,MD,ChadJessup,MD,MS,and MartinC.Mihm,Jr.,MD

166 Lipodermatosclerosis

WangL.Cheung,MD,PhD

168 TraumaticPanniculitis

GretchenW.Frieling,MD

170 EosinophilicPanniculitis

GeorgeR.Collins,DO,JosephSusa,DO,andClayJ. Cockerell,MD

172 ErythemaInduratum

CaryChisholm,MD

176 ScleremaNeonatorum

GeorgeR.Collins,DO,JosephSusa,DO,andClayJ. Cockerell,MD

178 SubcutaneousFatNecrosisoftheNewborn

JessicaM.Comstock,MD

180 Post-SteroidPanniculitis

TravisVandergriff,MD

182 ColdPanniculitis

KiranMotaparthi,MD

184 PancreaticPanniculitis

GretchenW.Frieling,MD

SECTION6:CONNECTIVETISSUE/SOFT TISSUEDISEASES

188 Scar

TalleyWhang,MD

190 Keloid

ChadJessup,MD,MS

192 LupusErythematosusandVariants

JulieE.Jackson,MDandChandraN.Smart,MD

200 Morphea/Scleroderma

SudeepGaudi,MDandDraženM.Jukić,MD,PhD

204 Dermatomyositis

SudeepGaudi,MDandDraženM.Jukić,MD,PhD

208 Radiodermatitis

TalleyWhang,MD

210 EosinophilicFasciitis

CaryChisholm,MD

212 NodularFasciitis

CaryChisholm,MDandElizabethA.Montgomery,MD

216 PseudoxanthomaElasticum

IrinaMargaritescu,MD,PhD

218 RelapsingPolychondritis

AparcheYang,MDandSharonJacob,MD

220 NephrogenicFibrosingDermopathy(Nephrogenic SystemicFibrosis)

CaryChisholm,MD

222 Atrophoderma

GretchenW.Frieling,MD

224 Favre-RacouchotSyndrome

TalleyWhang,MD

226 CollagenousandElastoticMarginalPlaquesofthe Hands

TravisVandergriff,MD

228 ErythemaAbIgne

KiranMotaparthi,MD

232 Anetoderma

CaryChisholm,MD

234 CutisLaxa

KiranMotaparthi,MD

236 Acrokeratoelastoidosis

BrianJ.Hall,MDandDirkElston,MD

TABLE OF CONTENTS

SECTION7:DEGENERATIVEAND PERFORATINGDISEASES

240 ChondrodermatitisNodularisHelicis

BrianJ.Hall,MDandJohnC.Hall,MD

242 PerforatingDermatoses

BrianJ.Hall,MD,JohnC.Hall,MD,andDirkElston,MD

246 ElephantiasisNostrasVerrucosa

TravisVandergriff,MD

SECTION8:METABOLIC/DEPOSITION DISEASES

250 AcanthosisNigricans

CaryChisholm,MD

252 ConfluentandReticulatedPapillomatosis

ChadJessup,MD,MS

254 Amyloidosis

KajsaAffolter,MD

258 ColloidMilium

ChadJessup,MD,MS

260 CalcinosisCutis

DirkElston,MDandCarlyA.Elston,MD

264 OsteomaCutis

AndrewWalls,MD

266 Gout

CaryChisholm,MD

268 TattooInk

KiranMotaparthi,MD

272 ReactiontoCosmeticFillers

TravisVandergriff,MD

276 SiliconeReaction

CaryChisholm,MD

278 AmalgamTattoo

SusanMüller,DMD,MS

280 Argyria

TalleyWhang,MD

282 MinocyclineDeposition

ChadJessup,MD,MS

284 MonselReaction

BrianJ.Hall,MD

286 Calciphylaxis

WangL.Cheung,MD,PhD

288 Ochronosis

DianeL.Wang,MD,GeorgeR.Collins,DO,andClayJ. Cockerell,MD

292 LipoidProteinosis

AtsukoKodama,MD,JosephSusa,DO,andClayJ. Cockerell,MD

294 NecrolyticMigratoryErythema

CaryChisholm,MD

SECTION9:MUCINOSES

298 FocalCutaneousMucinosis

CaryChisholm,MD

300 Myxedema

BrianJ.Hall,MDandJohnC.Hall,MD

302 PapularMucinosis

BrianJ.Hall,MDandBruceR.Smoller,MD

304 Scleredema

BrianJ.Hall,MDandDirkElston,MD

306 ReticularErythematousMucinosis

BrianJ.Hall,MDandDavidJ.DiCaudo,MD

308 DigitalMucousCyst

DavidS.Cassarino,MD,PhDandSenaitDyson,MD

310 Mucocele

ChadJessup,MD,MS

312 CutaneousMyxoma

AnnieO.Morrison,MDandClayJ.Cockerell,MD

314 FollicularMucinosis

KiranMotaparthi,MD

SECTION10:GRANULOMATOUS DISEASES

320 Sarcoidosis

BrianJ.Hall,MDandJohnC.Hall,MD

324 GranulomaAnnulare

ChristineJ.Ko,MD

326 NecrobiosisLipoidica

ChristineJ.Ko,MD

328 ForeignBodyGranuloma

BrianJ.Hall,MDandJohnC.Hall,MD

330 RheumatoidNodule

BrianJ.Hall,MDandJohnC.Hall,MD

332 ActinicGranuloma

KiranMotaparthi,MD

336 AnnularElastolyticGiantCellGranuloma

CaryChisholm,MD

338 Melkersson-RosenthalSyndrome

BrianJ.Hall,MDandJohnC.Hall,MD

340 MulticentricReticulohistiocytosis

ChristineJ.Ko,MD

342 NecrobioticXanthogranuloma

ChristineJ.Ko,MD

344 PerioralDermatitis

KiranMotaparthi,MD

348 LupusMiliarisDisseminatusFaciei

TalleyWhang,MD

350 CutaneousCrohnDisease

BrianJ.Hall,MD

354 InterstitialGranulomatousDermatitis

AndrewWalls,MD

356 PalisadedNeutrophilicGranulomatousDermatitis

AndrewWalls,MD

SECTION11:PILOSEBACEOUSDISEASES

360 Folliculitis

KiranMotaparthi,MD,CarlyA.Elston,MD,andCary

Chisholm,MD

366 Acne

ViseslavTonkovic-Capin,MD,CaryChisholm,MD,and ClayJ.Cockerell,MD

370 Rosacea

DianeL.Wang,MD,GeorgeR.Collins,DO,andClayJ. Cockerell,MD

TABLE OF CONTENTS

374 HidradenitisSuppurativa

MichelleLuceroJackson,MD,CaryChisholm,MD,and ClayJ.Cockerell,MD

376 Furuncle

ConnieV.Tran,BA,AnnieO.Morrison,MD,andClayJ. Cockerell,MD

378 EosinophilicPustularFolliculitis

ChristineJ.Ko,MD

380 Fox-FordyceDisease

MichaelW.Peterson,DO,CaryChisholm,MD,andClayJ. Cockerell,MD

382 Chloracne

TravisVandergriff,MD

SECTION12:ALOPECIAS

386 AndrogeneticAlopecia

GarthFraga,MD

390 TelogenEffluvium

GarthFraga,MD

392 Trichotillomania

GarthFraga,MD

396 AlopeciaAreata

GarthFraga,MD

400 LichenPlanopilaris

ChadJessup,MD,MS

404 DiscoidLupusAlopecia

TalleyWhang,MD

406 CentralCentrifugalCicatricialAlopecia

GarthFraga,MD

410 FolliculitisDecalvans

GarthFraga,MD

414 AcneKeloidalisNuchae

ChristieRiemer,BS,AnnieO.Morrison,MD,andClayJ. Cockerell,MD

416 DissectingCellulitis

ChadJessup,MD,MS

SECTION13:REACTIONSTODRUGS

420 MorbilliformDrugReactions

BrianJ.Hall,MD,GarthFraga,MD,andDavidJ.DiCaudo, MD

424 FixedDrugEruption

CarlyA.Elston,MDandDirkElston,MD

426 LichenoidDrugEruptions

KiranMotaparthi,MD

430 PhotodrugEruptions

ChadJessup,MD,MS

432 PhototoxicDermatitis

TravisVandergriff,MD

434 AcuteGeneralizedExanthematousPustulosis

GretchenW.Frieling,MD,DavidJ.DiCaudo,MD,and MartinC.Mihm,Jr.,MD

436 DrugRashWithEosinophiliaandSystemic Symptoms

GretchenW.Frieling,MD,ChadJessup,MD,MS,and

MartinC.Mihm,Jr.,MD

438 ToxicErythemaofChemotherapy

TravisVandergriff,MD

SECTION14:DISORDERSOFEPIDERMAL MATURATIONANDKERATINIZATION

442 GroverDisease

AtsukoKodama,MD,JosephSusa,DO,andClayJ. Cockerell,MD

446 DarierDisease

IrinaMargaritescu,MD,PhD

450 Porokeratosis

GeorgeR.Collins,DO,JosephSusa,DO,andClayJ. Cockerell,MD

454 Ichthyosis

MichaelW.Peterson,DO,CaryChisholm,MD,andClayJ. Cockerell,MD

456 EpidermolyticHyperkeratosis

ViseslavTonkovic-Capin,MD,JosephSusa,DO,andClayJ. Cockerell,MD

458 GranularParakeratosis

ChristineJ.Ko,MD

460 IncontinentiaPigmenti

ChristineJ.Ko,MD

462 KeratosisPilaris

TravisVandergriff,MD

464 CircumscribedAcralHypokeratosis

BrianJ.Hall,MD

466 ILVEN

CaryChisholm,MD

SECTION15:DISORDERSOF PIGMENTATION

470 Vitiligo

CaryChisholm,MD

472 PostinflammatoryPigmentAlteration

ChristieRiemer,BS,AnnieO.Morrison,MD,andClayJ. Cockerell,MD

474 PityriasisAlba

BrianJ.Hall,MD

476 BeckerNevus

AndrewWalls,MDandAnnieO.Morrison,MD

478 Melasma

BrianJ.Hall,MD

480 IdiopathicGuttateHypomelanosis

KiranMotaparthi,MD

482 Dowling-DegosDisease

BrianJ.Hall,MDandDirkElston,MD

SECTION16:NEUTROPHILIC DERMATOSES

488 SweetSyndrome

BrianJ.Hall,MDandBruceR.Smoller,MD

490 PyodermaGangrenosum

BrianJ.Hall,MDandGarthFraga,MD

492 SubcornealPustularDermatosis

BrianJ.Hall,MDandDirkElston,MD

494 NeutrophilicEccrineHidradenitis

CaryChisholm,MD

TABLE OF CONTENTS

SECTION17:NUTRITIONALDEFICIENCIES

498 NecrolyticAcralErythema

AnnieO.Morrison,MD

500 Pellagra

ChristieRiemer,BS,AnnieO.Morrison,MD,andClayJ. Cockerell,MD

502 Scurvy

AnnieO.Morrison,MDandTiffanyChen,MD

504 AcrodermatitisEnteropathica

TalleyWhang,MD

SECTION18:PHOTOSENSITIVITY DERMATOSES

508 PolymorphousLightEruption

BrianJ.Hall,MD,DirkElston,MD,andBruceR.Smoller, MD

510 ChronicActinicDermatitis

KiranMotaparthi,MD

514 HydroaVacciniforme

BrianJ.Hall,MD

SECTION19:BACTERIALINFECTIONS

518 Impetigo

IrinaMargaritescu,MD,PhD

522 Cellulitis

BrianJ.Hall,MDandJohnC.Hall,MD

524 NecrotizingFasciitis

BrianJ.Hall,MDandJohnC.Hall,MD

526 EcthymaGangrenosum

CaryChisholm,MD

528 StaphylococcalScaldedSkinSyndrome

BrianJ.Hall,MD

530 LymeDiseaseandItsManifestations

CorneliaS.L.Müller,MDandBruceR.Smoller,MD

534 Tuberculosis

FranciscoBravo,MDandPatriciaJ.Alvarez,MD

542 AtypicalMycobacterialInfections

CaryChisholm,MD

544 Leprosy

BrianJ.Hall,MD,FranciscoBravo,MD,andDirkElston, MD

552 CatScratchDisease/BacillaryAngiomatosis

IrinaMargaritescu,MD,PhDandBruceR.Smoller,MD

558 NocardiosisandActinomycosis

BrianJ.Hall,MDandDavidJ.DiCaudo,MD

564 RockyMountainSpottedFever

AparcheYang,MDandSharonJacob,MD

566 Rhinoscleroma

PatriciaJ.Alvarez,MDandFranciscoBravo,MD

568 Ecthyma

CaryChisholm,MD

570 Erythrasma

CaryChisholm,MD

572 CutaneousMalakoplakia

CaryChisholm,MD

SECTION20:SPIROCHETALDISEASES

576 Syphilis

GonzaloDeToro,MD

SECTION21:VIRALINFECTIONS

580 ViralExanthem

ChadJessup,MD,MS

584 Herpesvirus

WangL.Cheung,MD,PhD

586 Varicella/HerpesZoster

TalleyWhang,MD,ChadJessup,MD,MS,andMartinC. Mihm,Jr.,MD

590 Epstein-BarrVirusInfections

MichelleLuceroJackson,MD,JosephSusa,DO,andClay J.Cockerell,MD

594 Cytomegalovirus

ViseslavTonkovic-Capin,MD,CaryChisholm,MD,and ClayJ.Cockerell,MD

596 OrfandMilker'sNodule

NoelleWilliams,MD,ChadJessup,MD,MS,andMartinC. Mihm,Jr.,MD

598 Hand,Foot,andMouthDisease

CaryChisholm,MD

SECTION22:FUNGALINFECTIONS

602 Dermatophytosis

ChristineJ.Ko,MD

604 MajocchiGranuloma

AndrewWalls,MD

606 Onychomycosis

ChadJessup,MD,MS

608 Pityriasis(Tinea)Versicolor

KiranMotaparthi,MD

610 TineaNigra

TravisVandergriff,MD

612 Candidiasis

IrinaMargaritescu,MD,PhDandBruceR.Smoller,MD

616 Sporotrichosis

GretchenW.Frieling,MD,ChadJessup,MD,MS,and MartinC.Mihm,Jr.,MD

618 Coccidioidomycosis

BrianJ.Hall,MDandDavidJ.DiCaudo,MD

620 Cryptococcosis

PatriciaJ.Alvarez,MDandFranciscoBravo,MD

624 Histoplasmosis

CorneliaS.L.Müller,MDandBruceR.Smoller,MD

626 Blastomycosis

BrianJ.Hall,MDandDavidJ.DiCaudo,MD

628 Chromomycosis

BrianJ.Hall,MDandDavidJ.DiCaudo,MD

630 Aspergillosis

AndrewWalls,MD,ChadJessup,MD,MS,andMartinC. Mihm,Jr.,MD

634 Zygomycosis

BrianJ.Hall,MD,JohnC.Hall,MD,andDavidJ.DiCaudo, MD

636 Mycetoma

TABLE OF CONTENTS

BrianJ.Hall,MDandFranciscoBravo,MD

640 Paracoccidioidomycosis

FranciscoBravo,MDandPatriciaJ.Alvarez,MD

644 Lobomycosis

PatriciaJ.Alvarez,MDandFranciscoBravo,MD

646 Rhinosporidiosis

BrianJ.Hall,MDandDavidJ.DiCaudo,MD

648 Phaeohyphomycosis

ConnieV.Tran,BA,AnnieO.Morrison,MD,andClayJ. Cockerell,MD

650 Penicilliosis

DannyA.Milner,Jr.,MD,MSc

SECTION23:ARTHROPODS/PARASITES

654 DemodexInfestations

MalakAbedalthagafi,MDandDannyA.Milner,Jr.,MD, MSc

656 BiteReactions

AtsukoKodama,MD,JosephSusa,DO,andClayJ. Cockerell,MD

660 Scabies

GonzaloDeToro,MD

662 Leishmaniasis

BrianJ.Hall,MDandFranciscoBravo,MD

666 LarvaMigransandCurrens

AtsukoKodama,MD,JosephSusa,DO,andClayJ. Cockerell,MD

668 Onchocerciasis

GeorgeR.Collins,DO,DirkElston,MD,andClayJ. Cockerell,MD

670 Schistosomiasis

MichaelW.Peterson,DO,CaryChisholm,MD,andClayJ. Cockerell,MD

672 Dirofilariasis

NoelleWilliams,MD,ChadJessup,MD,MS,andDirk Elston,MD

674 Myiasis

TravisVandergriff,MD

676 Tungiasis

BrianJ.Hall,MD

678 Pediculosis

AnnieO.Morrison,MD

680 HumanFilariasis

EleanorRussell-Goldman,MD,PhD

SECTION24:OTHER

686 CutaneousEndometriosis

BrianJ.Hall,MD

690 WellsSyndrome

AndrewWalls,MD

692 ThermalInjury

ConnieV.Tran,BA,AnnieO.Morrison,MD,andClayJ. Cockerell,MD

696 BlackHeel

KiranMotaparthi,MD

698 AccessoryTragus

CaryChisholm,MD

700 SupernumeraryNipple

FatimaA.Khan,MD,AnnieO.Morrison,MD,andClayJ. Cockerell,MD

SECOND EDITION

HALL | COCKERELL

CHISHOLM • JESSUP • VANDERGRIFF

MOTAPARTHI • ELSTON

Spongiotic and Psoriasiform Dermatoses