https://ebookmass.com/product/neurology-and-pregnancy-
Instant digital products (PDF, ePub, MOBI) ready for you
Download now and discover formats that fit your needs...
Neurology
and Pregnancy: Neuro-Obstetric Disorders 1st Edition Eric A.P. Steegers (Editor)
https://ebookmass.com/product/neurology-and-pregnancy-neuro-obstetricdisorders-1st-edition-eric-a-p-steegers-editor/
ebookmass.com
Patient Care Skills (Patient Care Skills ( Minor)) 7th Edition, (Ebook PDF)
https://ebookmass.com/product/patient-care-skills-patient-care-skillsminor-7th-edition-ebook-pdf/
ebookmass.com
Introduction to Sonography and Patient Care First Edition, (Ebook PDF)
https://ebookmass.com/product/introduction-to-sonography-and-patientcare-first-edition-ebook-pdf/
ebookmass.com
Statistics for Engineers and Scientists 5th Edition
William Navidi
https://ebookmass.com/product/statistics-for-engineers-andscientists-5th-edition-william-navidi/
ebookmass.com
Harper's Illustrated Biochemistry, 32th ed 32nd Edition
Peter J. Kennelly
https://ebookmass.com/product/harpers-illustrated-biochemistry-32thed-32nd-edition-peter-j-kennelly/
ebookmass.com
Medicina Interna 18th Edition P. Farreras Valenti
https://ebookmass.com/product/medicina-interna-18th-edition-pfarreras-valenti/
ebookmass.com
William Penn: A Life Andrew R. Murphy
https://ebookmass.com/product/william-penn-a-life-andrew-r-murphy/
ebookmass.com
Essentials of Dyslexia Assessment and Intervention 1st Edition
https://ebookmass.com/product/essentials-of-dyslexia-assessment-andintervention-1st-edition/
ebookmass.com
Multi-Scale Approaches in Drug Discovery. From Empirical Knowledge to In Silico Experiments and Back 1st Edition Edition Alejandro Speck-Planche (Eds.)
https://ebookmass.com/product/multi-scale-approaches-in-drugdiscovery-from-empirical-knowledge-to-in-silico-experiments-andback-1st-edition-edition-alejandro-speck-planche-eds/
ebookmass.com
Handbook of Humanitarian Medicine 1st Edition
Edition Amy Kravitz
https://ebookmass.com/product/oxford-handbook-of-humanitarianmedicine-1st-edition-edition-amy-kravitz/
ebookmass.com
Table of Contents
Cover image
Title page
Copyright
Handbook of Clinical Neurology 3rd Series
Foreword
Preface
Contributors
Section I: Neurophysiologic changes in pregnancy
Chapter 1: Neuroendocrine mechanisms of reproduction
Abstract
Introduction
The Role of the Gonadotropin-Releasing Hormone (GnRH)
“Pulse Generator” in Initiation and Maintenance of Gonadal
Function
Neuroendocrinology of Puberty
Neuroendocrinology of the Menstrual Cycle
Functional Hypothalamic Amenorrhea/Anovulation
Polycystic Ovary Syndrome
Functional Hypothalamic Hypogonadism (FHH) in Men
The Neuroendocrinology of Pregnancy
Summary
Chapter 2: Neurophysiological and cognitive changes in pregnancy
Abstract
Introduction
Changes in Hormones During Pregnancy
Neurophysiological Changes in the Maternal Brain
Adaptive Changes in Central Control of Maternal Physiology
Adaptive Changes in Behavior
Cognitive Changes
Summary and Concluding Remarks
Chapter 3: Adaptations in autonomic nervous system regulation in normal and hypertensive pregnancy
Abstract
Introduction
Longitudinal changes in hemodynamics and hormones
Pregnancy increases SNA
Pregnancy Impairs Baroreflex Control of HR and SNA
Preeclampsia Elicits Further Increases in SNA
Summary and Future Directions
Acknowledgments
Chapter 4: Physiology of the cerebrovascular adaptation to pregnancy
Abstract
Introduction
Vasomotor Responses to Circulating Factors
The Cerebral Endothelium and BBB
CBF Autoregulation and Hemodynamics
Function and Structure of the Cerebrovasculature
Conclusions
Chapter 5: Neurobiology of maternal mental illness
Abstract
Introduction
Neuroplasticity in Pregnancy
Neuroendocrinology and Immune Changes in Pregnancy
Perinatal Depression
Perinatal Anxiety and OCD
Postpartum Psychosis and Bipolar Disorder
Trauma and Posttraumatic Stress Disorder
Discussion
Section II: The pregnant patient: General issues in neurologic care
Chapter 6: Epidemiology of neurologic disease in pregnancy
Abstract
Cerebrovascular Disease
Epilepsy
Demyelinating Diseases
Neuromuscular Disease
Headache
Movement Disorders
Cranial neuropathies
Ophthalmologic Disorders
Neuro-Oncology
Sleep Disorders
Neurologic Infectious Disease
Neurologic Intensive Care
Neurologic Complications of Systemic Disease
Psychiatric Disease
Conclusion
Chapter 7: Neuro-obstetrics: A multidisciplinary approach to care of women with neurologic disease
Abstract
Introduction
Preconception Care: Special Considerations
Specialist Individual Preconception Care
Conclusion
Chapter 8: Perinatal pharmacology and safety profiles
Abstract
Introduction: Perinatal Pharmacology Reflects Perinatal Physiology
Maternal Pharmacokinetics
Placental Transfer and Fetal Safety
Lactation and Newborn Safety
How to Improve the Current Setting
Acknowledgments and conflict of interest
Chapter 9: Neuroimaging and radiation exposure in pregnancy
Abstract
Introduction
Safety of Neuroimaging in Pregnancy and Lactation
Radiographic Characteristics of Neurologic Conditions Associated With Pregnancy
Summary
Chapter 10: Neuro-anesthesiology in pregnancy
Abstract
Introduction
Basic Considerations Related to the Provision of Anesthesia in the Obstetric Patient
Chronic Neurologic Conditions and Anesthetic Management of the Pregnant Patient Requiring Surgery
Acute Neurologic Diseases That May Require Anesthetic Care in Pregnant Women
Fetal and Neonatal Considerations in the Pregnant Patient
Undergoing Neurosurgery
Conclusion
Chapter 11: Neurocritical care of the pregnant patient
Abstract
Introduction
General Consideration for Neurocritical Care in the Pregnant Patient
Hypertensive Disorders of Pregnancy: Preeclampsia, Eclampsia, HELLP Syndrome
Intracranial Neoplasms
Noneclamptic Seizures
Cerebrovascular Disorders
Ventriculoperitoneal Shunt Malfunction
Conclusions
Chapter 12: Neurologic complications of medical conditions in pregnancy
Abstract
Sickle Cell Disease
Antiphospholipid Antibody Syndrome
Cardiac Valve Disease
HIV Infection
Connective Tissue Disorders
Systemic Lupus Erythematosus
Summary
Chapter 13: The ethics of neurologically complicated pregnancies
Abstract
Introduction
Ethical Theories
Application of Ethical Frameworks at the Interface of Obstetrics and Neurology
Reproductive Decisions in Intellectually Disabled Pregnant Women
Treatment of Neurologic Conditions in Pregnancy: Shared Decision-Making
Brain Death and Disorders of Consciousness in Pregnancy
The Ethics Committee
Section III: Prenatal neurologic diagnoses: Pathophysiology, diagnosis, and management
Chapter 14: The developing brain by trimester
Abstract
The Developing Brain per Trimester: Development to Acquired Lesions
Germinal Matrix (GM)
Development of Arteries
Development of Veins
Primary Gyration
Development of White Matter (WM)
Development of Cerebellum
Fluid Production and Ventricular Size
Chapter 15: Diagnosis and management of congenital neurologic disease during pregnancy
Abstract
Fetal Ventriculomegaly
Midline Abnormalities
Neural Tube Defects (NTDs)
Tuberous Sclerosis Complex (TSC)
Schizencephaly
Periventricular Nodular Heterotopia (PNH)
Brain Tumors
Fetal Stroke
Conclusion
Chapter 16: Perinatal stroke
Abstract
Introduction
Gestational Cerebrovascular Development
Neonatal Cerebrovascular Development and Autoregulation of Cerebral Blood Flow
Classification of Perinatal Stroke
Risk Factors for Perinatal Stroke
Conclusion
Index
Handbook of Clinical Neurology 3rd Series
Foreword
Michael J. Aminoff; François Boller; Dick F. Swaab
Pregnancy and childbirth directly concern a sizeable portion of the world's population. The nervous system participates in these processes in many ways and makes them possible through hormonal changes. In addition, any treatment of a pregnant patient may have important and often long-term consequences for the developing fetus. Yet, standard neurology textbooks often fail to discuss these topics in any depth. The previous series of the Handbook of Clinical Neurology (HCN) had close to 100 entries under the indexed heading of “Pregnancy,” but these usually consisted of footnotes added to the discussion of major disorders such as headache or epilepsy. Therefore we are proud to introduce the present two volumes dedicated to various aspects of neurology and pregnancy.
The first volume is dedicated to the neurophysiologic changes that accompany pregnancy, an overview of the neurologic and psychiatric diseases seen during that period, and the approach to the care of these conditions. A chapter entitled “Neuro-obstetrics” emphasizes the need for a multidisciplinary approach to the care of women with neurologic comorbidities, both preconceptionally and throughout pregnancy. Other chapters discuss in detail neuroimaging and radiation exposure during pregnancy as well as the ethical aspects of complicated pregnancies. The volume concludes with a discussion of the diagnosis and management of congenital neurologic diseases during pregnancy.
The second volume deals in detail with neurologic disorders that may accompany pregnancy, such as stroke, trauma, and neurologic complications associated with preeclampsia and eclampsia. There
are chapters that discuss compression neuropathies, acute psychiatric illnesses, migraine and other headaches, movement disorders, disorders of sleep, and CNS tumors. Moreover, a chapter is dedicated to the management of chronic neurologic disorders during pregnancy.
We have had the good fortune of working with three experienced and world-renowned volume editors. Prof. Eric A.P. Steegers is a gynecologist and the head of the Department of Obstetrics & Gynecology at the Erasmus University Medical Center in Ro erdam. Dr. Marilyn J. Cipolla is professor in the Department of Neurological Sciences with joint appointments in Obstetrics, Gynecology & Reproductive Sciences and Pharmacology at the University of Vermont Larner College of Medicine, Burlington. Dr. Eliza C. Miller is a vascular neurologist and assistant professor of neurology in the Division of Stroke and Cerebrovascular Disease at Columbia University, New York City. As series editors, we reviewed all the chapters in the volumes and made suggestions for improvement, but we are delighted that the volume editors and chapter authors produced such scholarly and comprehensive accounts of different aspects of the neurology of pregnancy. Hence, we hope that the volumes will appeal to clinicians and neuroscientists alike. Our goal is to provide clinicians with a state-of-the-art reference that summarizes the clinical features and management of the many neurologic manifestations of pregnancy. We also intend to provide basic researchers with the foundations for new approaches to the study of the complex changes that accompany pregnancy.
In addition to the print version, the chapters in the two volumes are also available electronically on Elsevier's ScienceDirect website, which is becoming increasingly popular with readers and will improve the book's accessibility. Indeed, all the volumes in the present series of Handbook are available electronically on this website. This will make them even more accessible to readers and facilitate searches for specific information.
As always, it is a pleasure to thank Elsevier, our publisher, and in particular Michael Parkinson in Scotland, Nikki Levy and Kristi Anderson in San Diego, and Punithavathy Govindaradjane at
g y j
Elsevier Global Book Production in Chennai, for their assistance in the development and production of the Handbook of Clinical Neurology.
Preface
Eric A.P. Steegers; Marilyn J. Cipolla; Eliza C. Miller
Neurology and Pregnancy is a two-volume comprehensive multidisciplinary guide to best practices for neurologists, obstetricians, and other specialists who care for women with acute or chronic neurologic disorders. All aspects of care for the pregnant woman with neurologic illness, such as preconception care, genetic counseling, pregnancy in patients with chronic neurologic disorders, and acute pregnancy-related neurologic complications, are covered. Postpartum care and complications, including lactation concerns, are also addressed, as are the long-term effects of pregnancy and its associated problems on maternal brain health.
In the first volume (vol. 171 of the Handbook of Clinical Neurology), the complex neurophysiologic changes in pregnancy are summarized from a basic and translational science perspective. This is followed by a discussion of general issues relevant to the provision of multidisciplinary neurologic care for pregnant patients, including neuroimaging, the principles of neuro-obstetric critical care, and ethical and medicolegal concerns. The final part describes normal fetal cerebral development and summarizes the management of the most common prenatal neurologic disorders.
The second volume (vol. 172 of the Handbook of Clinical Neurology) covers acute neurologic disorders presenting in pregnancy, including preeclampsia/eclampsia, ischemic and hemorrhagic stroke, and infections of the central nervous system. This is followed by discussions of chronic neurologic conditions, such as epilepsy, migraine, and multiple sclerosis. As innovative care can be achieved only by the continuous integration of clinical management with
advances in research, all chapters provide insights into the newest developments in related translational neuroscience and the implications for the future of the field.
The many contributors to this volume reflect diverse perspectives, from basic and translational researchers to clinicians and clinical researchers in a broad range of specialties. We are grateful to have been given the opportunity to learn and benefit from their extraordinary expertise. Michael Parkinson, the development editor, has thoughtfully provided vital support throughout the process of bringing this work to publication.
We believe that this text will improve the complex multidisciplinary care needed for pregnant women with neurologic disorders, contribute to improved maternal and fetal outcomes, and enhance the long-term health of mothers affected by neurologic disease and also that of their children.
